-- dump date 20120504_154259 -- class Genbank::misc_feature -- table misc_feature_note -- id note 324057000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 324057000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 324057000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057000004 Walker A motif; other site 324057000005 ATP binding site [chemical binding]; other site 324057000006 Walker B motif; other site 324057000007 arginine finger; other site 324057000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 324057000009 DnaA box-binding interface [nucleotide binding]; other site 324057000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 324057000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 324057000012 putative DNA binding surface [nucleotide binding]; other site 324057000013 dimer interface [polypeptide binding]; other site 324057000014 beta-clamp/clamp loader binding surface; other site 324057000015 beta-clamp/translesion DNA polymerase binding surface; other site 324057000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 324057000017 recombination protein F; Reviewed; Region: recF; PRK00064 324057000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 324057000019 Walker A/P-loop; other site 324057000020 ATP binding site [chemical binding]; other site 324057000021 Q-loop/lid; other site 324057000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057000023 ABC transporter signature motif; other site 324057000024 Walker B; other site 324057000025 D-loop; other site 324057000026 H-loop/switch region; other site 324057000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 324057000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324057000030 anchoring element; other site 324057000031 dimer interface [polypeptide binding]; other site 324057000032 ATP binding site [chemical binding]; other site 324057000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324057000034 active site 324057000035 putative metal-binding site [ion binding]; other site 324057000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324057000037 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057000038 DNA gyrase subunit A; Validated; Region: PRK05560 324057000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 324057000040 CAP-like domain; other site 324057000041 active site 324057000042 primary dimer interface [polypeptide binding]; other site 324057000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057000050 Zn2+ binding site [ion binding]; other site 324057000051 Mg2+ binding site [ion binding]; other site 324057000052 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 324057000053 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 324057000054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057000055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057000056 catalytic residue [active] 324057000057 thymidylate kinase; Validated; Region: tmk; PRK00698 324057000058 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 324057000059 TMP-binding site; other site 324057000060 ATP-binding site [chemical binding]; other site 324057000061 Nitrogen regulatory protein P-II; Region: P-II; cl00412 324057000062 Protein of unknown function (DUF327); Region: DUF327; cl00753 324057000063 DNA polymerase III subunit delta'; Validated; Region: PRK08058 324057000064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057000065 PSP1 C-terminal conserved region; Region: PSP1; cl00770 324057000066 TSC-22/dip/bun family; Region: TSC22; cl01853 324057000067 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057000068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057000069 S-adenosylmethionine binding site [chemical binding]; other site 324057000070 Predicted methyltransferases [General function prediction only]; Region: COG0313 324057000071 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 324057000072 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 324057000073 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 324057000074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057000075 Zn2+ binding site [ion binding]; other site 324057000076 Mg2+ binding site [ion binding]; other site 324057000077 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324057000078 active site 324057000079 Domain of unknown function (DUF348); Region: DUF348; pfam03990 324057000080 Domain of unknown function (DUF348); Region: DUF348; pfam03990 324057000081 G5 domain; Region: G5; pfam07501 324057000082 3D domain; Region: 3D; cl01439 324057000083 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 324057000084 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 324057000085 putative active site [active] 324057000086 putative metal binding site [ion binding]; other site 324057000087 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 324057000088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057000089 S-adenosylmethionine binding site [chemical binding]; other site 324057000090 YabG peptidase U57; Region: Peptidase_U57; cl05250 324057000091 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 324057000092 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057000093 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 324057000094 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057000095 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324057000096 pur operon repressor; Provisional; Region: PRK09213 324057000097 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 324057000098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057000099 active site 324057000100 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 324057000101 homotrimer interaction site [polypeptide binding]; other site 324057000102 putative active site [active] 324057000103 SpoVG; Region: SpoVG; cl00915 324057000104 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 324057000105 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 324057000106 Substrate binding site; other site 324057000107 Mg++ binding site; other site 324057000108 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 324057000109 active site 324057000110 substrate binding site [chemical binding]; other site 324057000111 CoA binding site [chemical binding]; other site 324057000112 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 324057000113 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 324057000114 5S rRNA interface [nucleotide binding]; other site 324057000115 CTC domain interface [polypeptide binding]; other site 324057000116 L16 interface [polypeptide binding]; other site 324057000117 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 324057000118 putative active site [active] 324057000119 catalytic residue [active] 324057000120 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 324057000121 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 324057000122 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 324057000123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057000124 ATP binding site [chemical binding]; other site 324057000125 putative Mg++ binding site [ion binding]; other site 324057000126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057000127 nucleotide binding region [chemical binding]; other site 324057000128 ATP-binding site [chemical binding]; other site 324057000129 TRCF domain; Region: TRCF; cl04088 324057000130 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 324057000131 PPIC-type PPIASE domain; Region: Rotamase; cl08278 324057000132 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 324057000133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 324057000134 stage V sporulation protein T; Region: spore_V_T; TIGR02851 324057000135 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 324057000136 Cupin domain; Region: Cupin_2; cl09118 324057000137 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057000138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000140 alpha-galactosidase; Provisional; Region: PRK15076 324057000141 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 324057000142 NAD binding site [chemical binding]; other site 324057000143 sugar binding site [chemical binding]; other site 324057000144 divalent metal binding site [ion binding]; other site 324057000145 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057000146 dimer interface [polypeptide binding]; other site 324057000147 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057000148 Glycerate kinase family; Region: Gly_kinase; cl00841 324057000149 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 324057000150 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 324057000151 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 324057000152 homodimer interface [polypeptide binding]; other site 324057000153 metal binding site [ion binding]; metal-binding site 324057000154 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 324057000155 homodimer interface [polypeptide binding]; other site 324057000156 active site 324057000157 putative chemical substrate binding site [chemical binding]; other site 324057000158 metal binding site [ion binding]; metal-binding site 324057000159 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 324057000160 IHF dimer interface [polypeptide binding]; other site 324057000161 IHF - DNA interface [nucleotide binding]; other site 324057000162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057000163 RNA binding surface [nucleotide binding]; other site 324057000164 Protein of unknown function (DUF817); Region: DUF817; cl01520 324057000165 YabP family; Region: YabP; cl06766 324057000166 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 324057000167 Septum formation initiator; Region: DivIC; cl11433 324057000168 hypothetical protein; Provisional; Region: PRK08582 324057000169 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057000170 RNA binding site [nucleotide binding]; other site 324057000171 stage II sporulation protein E; Region: spore_II_E; TIGR02865 324057000172 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 324057000173 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057000174 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057000175 metal ion-dependent adhesion site (MIDAS); other site 324057000176 Protein kinase domain; Region: Pkinase; pfam00069 324057000177 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057000178 active site 324057000179 ATP binding site [chemical binding]; other site 324057000180 substrate binding site [chemical binding]; other site 324057000181 activation loop (A-loop); other site 324057000182 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 324057000183 Ligand Binding Site [chemical binding]; other site 324057000184 B3/4 domain; Region: B3_4; cl11458 324057000185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057000186 active site 324057000187 FtsH Extracellular; Region: FtsH_ext; pfam06480 324057000188 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057000189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057000190 Walker A motif; other site 324057000191 ATP binding site [chemical binding]; other site 324057000192 Walker B motif; other site 324057000193 arginine finger; other site 324057000194 Peptidase family M41; Region: Peptidase_M41; pfam01434 324057000195 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 324057000196 ligand binding site [chemical binding]; other site 324057000197 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 324057000198 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057000199 Walker A/P-loop; other site 324057000200 ATP binding site [chemical binding]; other site 324057000201 Q-loop/lid; other site 324057000202 ABC transporter signature motif; other site 324057000203 Walker B; other site 324057000204 D-loop; other site 324057000205 H-loop/switch region; other site 324057000206 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057000207 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057000208 TM-ABC transporter signature motif; other site 324057000209 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057000210 TM-ABC transporter signature motif; other site 324057000211 Quinolinate synthetase A protein; Region: NadA; cl00420 324057000212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057000213 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 324057000214 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324057000215 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 324057000216 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 324057000217 dimerization interface [polypeptide binding]; other site 324057000218 active site 324057000219 Type III pantothenate kinase; Region: Pan_kinase; cl09130 324057000220 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 324057000221 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 324057000222 dimerization interface [polypeptide binding]; other site 324057000223 domain crossover interface; other site 324057000224 redox-dependent activation switch; other site 324057000225 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 324057000226 PPIC-type PPIASE domain; Region: Rotamase; cl08278 324057000227 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057000228 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057000229 dimer interface [polypeptide binding]; other site 324057000230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057000231 catalytic residue [active] 324057000232 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 324057000233 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 324057000234 chorismate binding enzyme; Region: Chorismate_bind; cl10555 324057000235 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 324057000236 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 324057000237 glutamine binding [chemical binding]; other site 324057000238 catalytic triad [active] 324057000239 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 324057000240 homodimer interface [polypeptide binding]; other site 324057000241 substrate-cofactor binding pocket; other site 324057000242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057000243 catalytic residue [active] 324057000244 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 324057000245 dihydropteroate synthase; Region: DHPS; TIGR01496 324057000246 substrate binding pocket [chemical binding]; other site 324057000247 dimer interface [polypeptide binding]; other site 324057000248 inhibitor binding site; inhibition site 324057000249 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 324057000250 homooctamer interface [polypeptide binding]; other site 324057000251 active site 324057000252 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 324057000253 catalytic center binding site [active] 324057000254 ATP binding site [chemical binding]; other site 324057000255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057000256 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 324057000257 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 324057000258 FMN binding site [chemical binding]; other site 324057000259 active site 324057000260 catalytic residues [active] 324057000261 substrate binding site [chemical binding]; other site 324057000262 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324057000263 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324057000264 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324057000265 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 324057000266 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 324057000267 dimer interface [polypeptide binding]; other site 324057000268 putative anticodon binding site; other site 324057000269 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 324057000270 motif 1; other site 324057000271 active site 324057000272 motif 2; other site 324057000273 motif 3; other site 324057000274 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 324057000275 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 324057000276 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 324057000277 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 324057000278 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 324057000279 Ligand binding site; other site 324057000280 Putative Catalytic site; other site 324057000281 DXD motif; other site 324057000282 GtrA-like protein; Region: GtrA; cl00971 324057000283 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057000284 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 324057000285 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057000286 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 324057000287 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057000288 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 324057000289 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 324057000290 active site 324057000291 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 324057000292 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057000293 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 324057000294 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 324057000295 active site 324057000296 multimer interface [polypeptide binding]; other site 324057000297 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 324057000298 predicted active site [active] 324057000299 catalytic triad [active] 324057000300 seryl-tRNA synthetase; Provisional; Region: PRK05431 324057000301 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 324057000302 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 324057000303 dimer interface [polypeptide binding]; other site 324057000304 active site 324057000305 motif 1; other site 324057000306 motif 2; other site 324057000307 motif 3; other site 324057000308 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324057000309 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324057000310 catalytic residues [active] 324057000311 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 324057000312 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057000313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324057000314 active site 324057000315 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 324057000316 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057000317 Walker A/P-loop; other site 324057000318 ATP binding site [chemical binding]; other site 324057000319 Q-loop/lid; other site 324057000320 ABC transporter signature motif; other site 324057000321 Walker B; other site 324057000322 D-loop; other site 324057000323 H-loop/switch region; other site 324057000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057000325 DinB superfamily; Region: DinB_2; pfam12867 324057000326 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057000327 Low molecular weight phosphatase family; Region: LMWPc; cl00105 324057000328 active site 324057000329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057000330 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324057000331 nucleoside/Zn binding site; other site 324057000332 dimer interface [polypeptide binding]; other site 324057000333 catalytic motif [active] 324057000334 sensory histidine kinase AtoS; Provisional; Region: PRK11360 324057000335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000336 dimerization interface [polypeptide binding]; other site 324057000337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057000338 putative active site [active] 324057000339 heme pocket [chemical binding]; other site 324057000340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057000341 dimer interface [polypeptide binding]; other site 324057000342 phosphorylation site [posttranslational modification] 324057000343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000344 ATP binding site [chemical binding]; other site 324057000345 Mg2+ binding site [ion binding]; other site 324057000346 G-X-G motif; other site 324057000347 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 324057000348 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 324057000349 NAD binding site [chemical binding]; other site 324057000350 active site 324057000351 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324057000352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057000353 RNA binding surface [nucleotide binding]; other site 324057000354 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 324057000355 probable active site [active] 324057000356 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 324057000357 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 324057000358 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 324057000359 ligand binding site [chemical binding]; other site 324057000360 flagellar motor protein MotA; Validated; Region: PRK08124 324057000361 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 324057000362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057000363 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 324057000364 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057000366 putative substrate translocation pore; other site 324057000367 NlpC/P60 family; Region: NLPC_P60; cl11438 324057000368 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 324057000369 Zn binding site [ion binding]; other site 324057000370 YwhD family; Region: YwhD; pfam08741 324057000371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057000372 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 324057000373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057000374 DNA binding residues [nucleotide binding] 324057000375 Putative zinc-finger; Region: zf-HC2; cl15806 324057000376 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324057000377 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 324057000378 active site 324057000379 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 324057000380 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 324057000381 Subunit I/III interface [polypeptide binding]; other site 324057000382 Subunit III/IV interface [polypeptide binding]; other site 324057000383 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 324057000384 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 324057000385 D-pathway; other site 324057000386 Putative ubiquinol binding site [chemical binding]; other site 324057000387 Low-spin heme (heme b) binding site [chemical binding]; other site 324057000388 Putative water exit pathway; other site 324057000389 Binuclear center (heme o3/CuB) [ion binding]; other site 324057000390 K-pathway; other site 324057000391 Putative proton exit pathway; other site 324057000392 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 324057000393 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057000394 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 324057000395 Transglycosylase; Region: Transgly; cl07896 324057000396 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057000397 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057000398 spermidine synthase; Provisional; Region: PRK00811 324057000399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057000400 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 324057000401 putative active site [active] 324057000402 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 324057000403 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 324057000404 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 324057000405 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 324057000406 active site 324057000407 HIGH motif; other site 324057000408 KMSK motif region; other site 324057000409 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 324057000410 tRNA binding surface [nucleotide binding]; other site 324057000411 anticodon binding site; other site 324057000412 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 324057000413 active site 324057000414 catalytic residues [active] 324057000415 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 324057000416 CTP synthetase; Validated; Region: pyrG; PRK05380 324057000417 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 324057000418 Catalytic site [active] 324057000419 active site 324057000420 UTP binding site [chemical binding]; other site 324057000421 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 324057000422 active site 324057000423 putative oxyanion hole; other site 324057000424 catalytic triad [active] 324057000425 Response regulator receiver domain; Region: Response_reg; pfam00072 324057000426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000427 active site 324057000428 phosphorylation site [posttranslational modification] 324057000429 intermolecular recognition site; other site 324057000430 dimerization interface [polypeptide binding]; other site 324057000431 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057000432 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057000433 hinge; other site 324057000434 active site 324057000435 transcription termination factor Rho; Provisional; Region: rho; PRK09376 324057000436 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 324057000437 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 324057000438 RNA binding site [nucleotide binding]; other site 324057000439 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 324057000440 multimer interface [polypeptide binding]; other site 324057000441 Walker A motif; other site 324057000442 ATP binding site [chemical binding]; other site 324057000443 Walker B motif; other site 324057000444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057000445 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324057000446 FeS/SAM binding site; other site 324057000447 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 324057000448 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 324057000449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057000450 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 324057000451 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 324057000452 recombination protein RecR; Reviewed; Region: recR; PRK00076 324057000453 RecR protein; Region: RecR; pfam02132 324057000454 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 324057000455 putative active site [active] 324057000456 putative metal-binding site [ion binding]; other site 324057000457 tetramer interface [polypeptide binding]; other site 324057000458 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 324057000459 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 324057000460 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057000461 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324057000462 Mg++ binding site [ion binding]; other site 324057000463 putative catalytic motif [active] 324057000464 substrate binding site [chemical binding]; other site 324057000465 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 324057000466 Helix-turn-helix domains; Region: HTH; cl00088 324057000467 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 324057000468 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 324057000469 Walker A/P-loop; other site 324057000470 ATP binding site [chemical binding]; other site 324057000471 Q-loop/lid; other site 324057000472 ABC transporter signature motif; other site 324057000473 Walker B; other site 324057000474 D-loop; other site 324057000475 H-loop/switch region; other site 324057000476 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057000477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057000478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057000479 DNA binding residues [nucleotide binding] 324057000480 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 324057000481 HPr kinase/phosphorylase; Provisional; Region: PRK05428 324057000482 DRTGG domain; Region: DRTGG; cl12147 324057000483 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 324057000484 Hpr binding site; other site 324057000485 active site 324057000486 homohexamer subunit interaction site [polypeptide binding]; other site 324057000487 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 324057000488 pyrophosphatase PpaX; Provisional; Region: PRK13288 324057000489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057000490 motif II; other site 324057000491 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057000492 trimer interface [polypeptide binding]; other site 324057000493 active site 324057000494 substrate binding site [chemical binding]; other site 324057000495 CoA binding site [chemical binding]; other site 324057000496 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 324057000497 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 324057000498 dimer interface [polypeptide binding]; other site 324057000499 motif 1; other site 324057000500 active site 324057000501 motif 2; other site 324057000502 motif 3; other site 324057000503 ATP phosphoribosyltransferase; Region: HisG; cl15266 324057000504 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 324057000505 histidinol dehydrogenase; Region: hisD; TIGR00069 324057000506 NAD binding site [chemical binding]; other site 324057000507 dimerization interface [polypeptide binding]; other site 324057000508 product binding site; other site 324057000509 substrate binding site [chemical binding]; other site 324057000510 zinc binding site [ion binding]; other site 324057000511 catalytic residues [active] 324057000512 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 324057000513 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 324057000514 putative active site pocket [active] 324057000515 4-fold oligomerization interface [polypeptide binding]; other site 324057000516 metal binding residues [ion binding]; metal-binding site 324057000517 3-fold/trimer interface [polypeptide binding]; other site 324057000518 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 324057000519 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 324057000520 putative active site [active] 324057000521 oxyanion strand; other site 324057000522 catalytic triad [active] 324057000523 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 324057000524 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 324057000525 substrate binding site [chemical binding]; other site 324057000526 glutamase interaction surface [polypeptide binding]; other site 324057000527 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 324057000528 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 324057000529 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 324057000530 metal binding site [ion binding]; metal-binding site 324057000531 histidinol-phosphatase; Provisional; Region: PRK07328 324057000532 PHP-associated; Region: PHP_C; pfam13263 324057000533 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324057000534 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324057000535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057000536 active site 324057000537 TPR repeat; Region: TPR_11; pfam13414 324057000538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057000539 binding surface 324057000540 TPR motif; other site 324057000541 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324057000542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057000543 TPR motif; other site 324057000544 binding surface 324057000545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057000546 TPR motif; other site 324057000547 binding surface 324057000548 HEAT repeats; Region: HEAT_2; pfam13646 324057000549 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324057000550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057000551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057000552 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 324057000553 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057000554 Acetokinase family; Region: Acetate_kinase; cl01029 324057000555 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 324057000556 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 324057000557 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 324057000558 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 324057000559 phosphate binding site [ion binding]; other site 324057000560 putative substrate binding pocket [chemical binding]; other site 324057000561 dimer interface [polypeptide binding]; other site 324057000562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 324057000563 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 324057000564 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057000565 dimerization domain swap beta strand [polypeptide binding]; other site 324057000566 regulatory protein interface [polypeptide binding]; other site 324057000567 active site 324057000568 regulatory phosphorylation site [posttranslational modification]; other site 324057000569 Clp protease; Region: CLP_protease; pfam00574 324057000570 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324057000571 oligomer interface [polypeptide binding]; other site 324057000572 active site residues [active] 324057000573 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 324057000574 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 324057000575 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 324057000576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057000577 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 324057000578 Phosphoglycerate kinase; Region: PGK; pfam00162 324057000579 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 324057000580 substrate binding site [chemical binding]; other site 324057000581 hinge regions; other site 324057000582 ADP binding site [chemical binding]; other site 324057000583 catalytic site [active] 324057000584 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 324057000585 substrate binding site [chemical binding]; other site 324057000586 dimer interface [polypeptide binding]; other site 324057000587 catalytic triad [active] 324057000588 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 324057000589 Sulfatase; Region: Sulfatase; cl10460 324057000590 enolase; Provisional; Region: eno; PRK00077 324057000591 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 324057000592 dimer interface [polypeptide binding]; other site 324057000593 metal binding site [ion binding]; metal-binding site 324057000594 substrate binding pocket [chemical binding]; other site 324057000595 Preprotein translocase SecG subunit; Region: SecG; cl09123 324057000596 ribonuclease R; Region: RNase_R; TIGR02063 324057000597 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057000598 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057000599 RNB domain; Region: RNB; pfam00773 324057000600 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 324057000601 RNA binding site [nucleotide binding]; other site 324057000602 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 324057000603 DNA-binding site [nucleotide binding]; DNA binding site 324057000604 RNA-binding motif; other site 324057000605 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 324057000606 SmpB-tmRNA interface; other site 324057000607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057000608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000609 dimerization interface [polypeptide binding]; other site 324057000610 Histidine kinase; Region: His_kinase; pfam06580 324057000611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000612 ATP binding site [chemical binding]; other site 324057000613 Mg2+ binding site [ion binding]; other site 324057000614 G-X-G motif; other site 324057000615 Response regulator receiver domain; Region: Response_reg; pfam00072 324057000616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000617 active site 324057000618 phosphorylation site [posttranslational modification] 324057000619 intermolecular recognition site; other site 324057000620 dimerization interface [polypeptide binding]; other site 324057000621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057000623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000624 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057000625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000627 dimer interface [polypeptide binding]; other site 324057000628 conserved gate region; other site 324057000629 putative PBP binding loops; other site 324057000630 ABC-ATPase subunit interface; other site 324057000631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000632 dimer interface [polypeptide binding]; other site 324057000633 conserved gate region; other site 324057000634 putative PBP binding loops; other site 324057000635 ABC-ATPase subunit interface; other site 324057000636 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057000637 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057000638 PAS fold; Region: PAS_4; pfam08448 324057000639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057000640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000641 ATP binding site [chemical binding]; other site 324057000642 Mg2+ binding site [ion binding]; other site 324057000643 G-X-G motif; other site 324057000644 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 324057000645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000646 active site 324057000647 phosphorylation site [posttranslational modification] 324057000648 intermolecular recognition site; other site 324057000649 dimerization interface [polypeptide binding]; other site 324057000650 Helix-turn-helix domains; Region: HTH; cl00088 324057000651 S-layer homology domain; Region: SLH; pfam00395 324057000652 S-layer homology domain; Region: SLH; pfam00395 324057000653 S-layer homology domain; Region: SLH; pfam00395 324057000654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057000655 Histidine kinase; Region: His_kinase; pfam06580 324057000656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000657 ATP binding site [chemical binding]; other site 324057000658 Mg2+ binding site [ion binding]; other site 324057000659 G-X-G motif; other site 324057000660 Response regulator receiver domain; Region: Response_reg; pfam00072 324057000661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000662 active site 324057000663 phosphorylation site [posttranslational modification] 324057000664 intermolecular recognition site; other site 324057000665 dimerization interface [polypeptide binding]; other site 324057000666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057000668 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057000669 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057000670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000671 dimer interface [polypeptide binding]; other site 324057000672 conserved gate region; other site 324057000673 ABC-ATPase subunit interface; other site 324057000674 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057000675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000676 dimer interface [polypeptide binding]; other site 324057000677 conserved gate region; other site 324057000678 putative PBP binding loops; other site 324057000679 ABC-ATPase subunit interface; other site 324057000680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057000682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000683 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057000684 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057000685 intersubunit interface [polypeptide binding]; other site 324057000686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057000687 ABC-ATPase subunit interface; other site 324057000688 dimer interface [polypeptide binding]; other site 324057000689 putative PBP binding regions; other site 324057000690 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057000691 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057000692 ABC-ATPase subunit interface; other site 324057000693 dimer interface [polypeptide binding]; other site 324057000694 putative PBP binding regions; other site 324057000695 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057000696 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057000697 intersubunit interface [polypeptide binding]; other site 324057000698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057000699 Helix-turn-helix domains; Region: HTH; cl00088 324057000700 N-carbamolyputrescine amidase; Region: PLN02747 324057000701 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 324057000702 putative active site; other site 324057000703 catalytic triad [active] 324057000704 putative dimer interface [polypeptide binding]; other site 324057000705 agmatine deiminase; Region: agmatine_aguA; TIGR03380 324057000706 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 324057000707 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057000708 Helix-turn-helix domains; Region: HTH; cl00088 324057000709 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057000710 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057000711 classical (c) SDRs; Region: SDR_c; cd05233 324057000712 NAD(P) binding site [chemical binding]; other site 324057000713 active site 324057000714 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057000715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057000716 motif II; other site 324057000717 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 324057000718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057000719 inhibitor-cofactor binding pocket; inhibition site 324057000720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057000721 catalytic residue [active] 324057000722 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057000723 Helix-turn-helix domains; Region: HTH; cl00088 324057000724 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057000725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057000726 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 324057000727 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 324057000728 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057000729 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057000730 metal binding site [ion binding]; metal-binding site 324057000731 ligand binding site [chemical binding]; other site 324057000732 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057000733 metal binding site [ion binding]; metal-binding site 324057000734 ligand binding site [chemical binding]; other site 324057000735 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057000736 metal binding site [ion binding]; metal-binding site 324057000737 ligand binding site [chemical binding]; other site 324057000738 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057000739 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057000740 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057000741 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 324057000742 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 324057000743 Ca binding site [ion binding]; other site 324057000744 carbohydrate binding site [chemical binding]; other site 324057000745 S-layer homology domain; Region: SLH; pfam00395 324057000746 S-layer homology domain; Region: SLH; pfam00395 324057000747 S-layer homology domain; Region: SLH; pfam00395 324057000748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057000749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057000750 putative substrate translocation pore; other site 324057000751 Protein of unknown function (DUF423); Region: DUF423; cl01008 324057000752 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057000753 active site 324057000754 metal binding site [ion binding]; metal-binding site 324057000755 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057000756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057000757 putative DNA binding site [nucleotide binding]; other site 324057000758 putative Zn2+ binding site [ion binding]; other site 324057000759 AsnC family; Region: AsnC_trans_reg; pfam01037 324057000760 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 324057000761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057000762 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057000763 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057000764 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057000765 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057000766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057000767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057000768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057000769 dimer interface [polypeptide binding]; other site 324057000770 putative CheW interface [polypeptide binding]; other site 324057000771 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 324057000772 Helix-turn-helix domains; Region: HTH; cl00088 324057000773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057000774 dimerization interface [polypeptide binding]; other site 324057000775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057000776 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057000777 putative substrate translocation pore; other site 324057000778 Helix-turn-helix domains; Region: HTH; cl00088 324057000779 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057000780 Helix-turn-helix domains; Region: HTH; cl00088 324057000781 DoxX; Region: DoxX; cl00976 324057000782 Domain of unknown function DUF302; Region: DUF302; cl01364 324057000783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057000784 Helix-turn-helix domains; Region: HTH; cl00088 324057000785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057000786 dimerization interface [polypeptide binding]; other site 324057000787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057000788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057000789 Coenzyme A binding pocket [chemical binding]; other site 324057000790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057000791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000792 active site 324057000793 phosphorylation site [posttranslational modification] 324057000794 intermolecular recognition site; other site 324057000795 dimerization interface [polypeptide binding]; other site 324057000796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057000797 DNA binding site [nucleotide binding] 324057000798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000799 dimerization interface [polypeptide binding]; other site 324057000800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057000801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057000802 dimer interface [polypeptide binding]; other site 324057000803 phosphorylation site [posttranslational modification] 324057000804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000805 ATP binding site [chemical binding]; other site 324057000806 Mg2+ binding site [ion binding]; other site 324057000807 G-X-G motif; other site 324057000808 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057000809 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057000810 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057000811 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 324057000812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324057000813 active site 324057000814 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 324057000815 BNR repeat-like domain; Region: BNR_2; pfam13088 324057000816 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 324057000817 Asp-box motif; other site 324057000818 Bacterial Ig-like domain; Region: Big_5; cl01012 324057000819 Bacterial Ig-like domain; Region: Big_5; cl01012 324057000820 Bacterial Ig-like domain; Region: Big_5; cl01012 324057000821 Bacterial Ig-like domain; Region: Big_5; cl01012 324057000822 Bacterial Ig-like domain; Region: Big_5; cl01012 324057000823 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 324057000824 dockerin binding interface; other site 324057000825 S-layer homology domain; Region: SLH; pfam00395 324057000826 S-layer homology domain; Region: SLH; pfam00395 324057000827 S-layer homology domain; Region: SLH; pfam00395 324057000828 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057000829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000830 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057000831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057000832 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057000833 active site 324057000834 catalytic tetrad [active] 324057000835 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 324057000836 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 324057000837 active site 324057000838 nucleophile elbow; other site 324057000839 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 324057000840 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 324057000841 HPP family; Region: HPP; pfam04982 324057000842 MATE family multidrug exporter; Provisional; Region: PRK10189 324057000843 MatE; Region: MatE; cl10513 324057000844 MatE; Region: MatE; cl10513 324057000845 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057000846 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057000847 Walker A/P-loop; other site 324057000848 ATP binding site [chemical binding]; other site 324057000849 Q-loop/lid; other site 324057000850 ABC transporter signature motif; other site 324057000851 Walker B; other site 324057000852 D-loop; other site 324057000853 H-loop/switch region; other site 324057000854 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057000855 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057000856 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057000857 Walker A/P-loop; other site 324057000858 ATP binding site [chemical binding]; other site 324057000859 Q-loop/lid; other site 324057000860 ABC transporter signature motif; other site 324057000861 Walker B; other site 324057000862 D-loop; other site 324057000863 H-loop/switch region; other site 324057000864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057000865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000866 dimer interface [polypeptide binding]; other site 324057000867 conserved gate region; other site 324057000868 putative PBP binding loops; other site 324057000869 ABC-ATPase subunit interface; other site 324057000870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057000871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000872 dimer interface [polypeptide binding]; other site 324057000873 conserved gate region; other site 324057000874 putative PBP binding loops; other site 324057000875 ABC-ATPase subunit interface; other site 324057000876 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 324057000877 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057000878 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057000879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000880 active site 324057000881 phosphorylation site [posttranslational modification] 324057000882 intermolecular recognition site; other site 324057000883 dimerization interface [polypeptide binding]; other site 324057000884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000887 dimerization interface [polypeptide binding]; other site 324057000888 Histidine kinase; Region: His_kinase; pfam06580 324057000889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000890 ATP binding site [chemical binding]; other site 324057000891 Mg2+ binding site [ion binding]; other site 324057000892 G-X-G motif; other site 324057000893 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057000894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000895 dimer interface [polypeptide binding]; other site 324057000896 conserved gate region; other site 324057000897 ABC-ATPase subunit interface; other site 324057000898 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057000899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000900 dimer interface [polypeptide binding]; other site 324057000901 conserved gate region; other site 324057000902 putative PBP binding loops; other site 324057000903 ABC-ATPase subunit interface; other site 324057000904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057000905 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057000906 putative hydrophobic ligand binding site [chemical binding]; other site 324057000907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057000908 dimerization interface [polypeptide binding]; other site 324057000909 putative DNA binding site [nucleotide binding]; other site 324057000910 putative Zn2+ binding site [ion binding]; other site 324057000911 DoxX; Region: DoxX; cl00976 324057000912 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057000913 dockerin binding interface; other site 324057000914 S-layer homology domain; Region: SLH; pfam00395 324057000915 S-layer homology domain; Region: SLH; pfam00395 324057000916 S-layer homology domain; Region: SLH; pfam00395 324057000917 amidase; Provisional; Region: PRK06828 324057000918 Amidase; Region: Amidase; cl11426 324057000919 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057000920 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057000921 Helix-turn-helix domains; Region: HTH; cl00088 324057000922 DinB superfamily; Region: DinB_2; pfam12867 324057000923 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 324057000924 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057000925 Helix-turn-helix domains; Region: HTH; cl00088 324057000926 WYL domain; Region: WYL; cl14852 324057000927 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057000928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057000929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000930 dimer interface [polypeptide binding]; other site 324057000931 conserved gate region; other site 324057000932 putative PBP binding loops; other site 324057000933 ABC-ATPase subunit interface; other site 324057000934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000935 dimer interface [polypeptide binding]; other site 324057000936 conserved gate region; other site 324057000937 ABC-ATPase subunit interface; other site 324057000938 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 324057000939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057000940 Walker A/P-loop; other site 324057000941 ATP binding site [chemical binding]; other site 324057000942 Q-loop/lid; other site 324057000943 ABC transporter signature motif; other site 324057000944 Walker B; other site 324057000945 D-loop; other site 324057000946 H-loop/switch region; other site 324057000947 TOBE domain; Region: TOBE_2; cl01440 324057000948 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 324057000949 PHP-associated; Region: PHP_C; pfam13263 324057000950 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324057000951 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324057000952 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324057000953 putative active site [active] 324057000954 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 324057000955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057000956 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 324057000957 PLD-like domain; Region: PLDc_2; pfam13091 324057000958 putative homodimer interface [polypeptide binding]; other site 324057000959 putative active site [active] 324057000960 catalytic site [active] 324057000961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057000962 ATP binding site [chemical binding]; other site 324057000963 putative Mg++ binding site [ion binding]; other site 324057000964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057000965 nucleotide binding region [chemical binding]; other site 324057000966 Restriction endonuclease [Defense mechanisms]; Region: COG3587 324057000967 ATP-binding site [chemical binding]; other site 324057000968 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 324057000969 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 324057000970 active site 324057000971 8-oxo-dGMP binding site [chemical binding]; other site 324057000972 nudix motif; other site 324057000973 metal binding site [ion binding]; metal-binding site 324057000974 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 324057000975 NPCBM/NEW2 domain; Region: NPCBM; cl07060 324057000976 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057000977 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057000978 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 324057000979 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 324057000980 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324057000981 active site 324057000982 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 324057000983 DNA-binding site [nucleotide binding]; DNA binding site 324057000984 RNA-binding motif; other site 324057000985 Cold-inducible protein YdjO; Region: YdjO; pfam14169 324057000986 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 324057000987 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 324057000988 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057000989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057000990 Helix-turn-helix domains; Region: HTH; cl00088 324057000991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057000992 dimerization interface [polypeptide binding]; other site 324057000993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057000994 short chain dehydrogenase; Validated; Region: PRK07069 324057000995 NAD(P) binding site [chemical binding]; other site 324057000996 active site 324057000997 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057000998 classical (c) SDRs; Region: SDR_c; cd05233 324057000999 NAD(P) binding site [chemical binding]; other site 324057001000 active site 324057001001 YibE/F-like protein; Region: YibE_F; cl02259 324057001002 HupE / UreJ protein; Region: HupE_UreJ; cl01011 324057001003 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057001004 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057001005 active site 324057001006 metal binding site [ion binding]; metal-binding site 324057001007 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 324057001008 S-layer homology domain; Region: SLH; pfam00395 324057001009 S-layer homology domain; Region: SLH; pfam00395 324057001010 S-layer homology domain; Region: SLH; pfam00395 324057001011 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057001012 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057001013 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057001014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057001015 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057001016 active site 324057001017 metal binding site [ion binding]; metal-binding site 324057001018 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057001019 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057001020 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001021 Amino acid permease; Region: AA_permease_2; pfam13520 324057001022 K+ potassium transporter; Region: K_trans; cl15781 324057001023 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 324057001024 Protein export membrane protein; Region: SecD_SecF; cl14618 324057001025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057001026 Helix-turn-helix domains; Region: HTH; cl00088 324057001027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001028 active site 324057001029 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057001030 catalytic tetrad [active] 324057001031 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057001032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001033 putative substrate translocation pore; other site 324057001034 Helix-turn-helix domains; Region: HTH; cl00088 324057001035 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001036 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001037 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001038 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001039 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001040 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057001042 Walker A motif; other site 324057001043 ATP binding site [chemical binding]; other site 324057001044 Walker B motif; other site 324057001045 arginine finger; other site 324057001046 Peptidase family M41; Region: Peptidase_M41; pfam01434 324057001047 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057001048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057001049 motif II; other site 324057001050 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057001051 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 324057001052 substrate binding site [chemical binding]; other site 324057001053 dimer interface [polypeptide binding]; other site 324057001054 ATP binding site [chemical binding]; other site 324057001055 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057001056 NodB motif; other site 324057001057 active site 324057001058 catalytic site [active] 324057001059 metal binding site [ion binding]; metal-binding site 324057001060 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057001061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057001062 DNA-binding site [nucleotide binding]; DNA binding site 324057001063 FCD domain; Region: FCD; cl11656 324057001064 mannonate dehydratase; Provisional; Region: PRK03906 324057001065 mannonate dehydratase; Region: uxuA; TIGR00695 324057001066 D-mannonate oxidoreductase; Provisional; Region: PRK08277 324057001067 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 324057001068 putative NAD(P) binding site [chemical binding]; other site 324057001069 active site 324057001070 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057001071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001072 active site 324057001073 catalytic tetrad [active] 324057001074 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057001075 DNA binding residues [nucleotide binding] 324057001076 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 324057001077 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324057001078 transglutaminase; Provisional; Region: tgl; PRK03187 324057001079 Cupin domain; Region: Cupin_2; cl09118 324057001080 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001082 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057001083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001084 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057001085 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057001086 AP (apurinic/apyrimidinic) site pocket; other site 324057001087 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057001088 DNA interaction; other site 324057001089 Metal-binding active site; metal-binding site 324057001090 NMT1-like family; Region: NMT1_2; cl15260 324057001091 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 324057001092 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 324057001093 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057001094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057001095 Helix-turn-helix domains; Region: HTH; cl00088 324057001096 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057001097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001098 putative substrate translocation pore; other site 324057001099 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057001100 Chain length determinant protein; Region: Wzz; cl15801 324057001101 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057001102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057001103 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 324057001104 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 324057001105 NAD(P) binding site [chemical binding]; other site 324057001106 homodimer interface [polypeptide binding]; other site 324057001107 substrate binding site [chemical binding]; other site 324057001108 active site 324057001109 MatE; Region: MatE; cl10513 324057001110 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324057001111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057001112 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 324057001113 putative ADP-binding pocket [chemical binding]; other site 324057001114 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057001115 trimer interface [polypeptide binding]; other site 324057001116 active site 324057001117 substrate binding site [chemical binding]; other site 324057001118 CoA binding site [chemical binding]; other site 324057001119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057001120 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057001121 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 324057001122 putative NAD(P) binding site [chemical binding]; other site 324057001123 active site 324057001124 putative substrate binding site [chemical binding]; other site 324057001125 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 324057001126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057001127 putative ADP-binding pocket [chemical binding]; other site 324057001128 Bacterial sugar transferase; Region: Bac_transf; cl00939 324057001129 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 324057001130 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 324057001131 putative trimer interface [polypeptide binding]; other site 324057001132 putative CoA binding site [chemical binding]; other site 324057001133 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 324057001134 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324057001135 inhibitor-cofactor binding pocket; inhibition site 324057001136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057001137 catalytic residue [active] 324057001138 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324057001139 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057001140 active site 324057001141 tetramer interface; other site 324057001142 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001144 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057001145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 324057001147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057001148 Coenzyme A binding pocket [chemical binding]; other site 324057001149 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057001150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057001151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057001152 DNA binding residues [nucleotide binding] 324057001153 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 324057001154 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057001155 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 324057001156 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057001157 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057001158 putative DNA binding site [nucleotide binding]; other site 324057001159 putative Zn2+ binding site [ion binding]; other site 324057001160 AsnC family; Region: AsnC_trans_reg; pfam01037 324057001161 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001163 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 324057001164 Cation efflux family; Region: Cation_efflux; cl00316 324057001165 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 324057001166 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 324057001167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001169 putative substrate translocation pore; other site 324057001170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057001171 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057001172 Cache domain; Region: Cache_1; pfam02743 324057001173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057001174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001175 metal binding site [ion binding]; metal-binding site 324057001176 active site 324057001177 I-site; other site 324057001178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 324057001179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057001180 ABC-ATPase subunit interface; other site 324057001181 dimer interface [polypeptide binding]; other site 324057001182 putative PBP binding regions; other site 324057001183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057001184 ABC-ATPase subunit interface; other site 324057001185 dimer interface [polypeptide binding]; other site 324057001186 putative PBP binding regions; other site 324057001187 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 324057001188 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057001189 siderophore binding site; other site 324057001190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001192 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001194 dimer interface [polypeptide binding]; other site 324057001195 conserved gate region; other site 324057001196 putative PBP binding loops; other site 324057001197 ABC-ATPase subunit interface; other site 324057001198 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057001199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001200 dimer interface [polypeptide binding]; other site 324057001201 conserved gate region; other site 324057001202 putative PBP binding loops; other site 324057001203 ABC-ATPase subunit interface; other site 324057001204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001205 dimerization interface [polypeptide binding]; other site 324057001206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057001207 Histidine kinase; Region: His_kinase; pfam06580 324057001208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001209 ATP binding site [chemical binding]; other site 324057001210 Mg2+ binding site [ion binding]; other site 324057001211 G-X-G motif; other site 324057001212 Response regulator receiver domain; Region: Response_reg; pfam00072 324057001213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001214 active site 324057001215 phosphorylation site [posttranslational modification] 324057001216 intermolecular recognition site; other site 324057001217 dimerization interface [polypeptide binding]; other site 324057001218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001221 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057001223 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057001224 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057001225 putative active site [active] 324057001226 FaeA-like protein; Region: FaeA; pfam04703 324057001227 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 324057001228 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057001229 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 324057001230 Walker A/P-loop; other site 324057001231 ATP binding site [chemical binding]; other site 324057001232 Q-loop/lid; other site 324057001233 ABC transporter signature motif; other site 324057001234 Walker B; other site 324057001235 D-loop; other site 324057001236 H-loop/switch region; other site 324057001237 TOBE domain; Region: TOBE_2; cl01440 324057001238 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057001239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001240 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057001241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001242 dimer interface [polypeptide binding]; other site 324057001243 conserved gate region; other site 324057001244 putative PBP binding loops; other site 324057001245 ABC-ATPase subunit interface; other site 324057001246 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324057001247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057001248 S-layer homology domain; Region: SLH; pfam00395 324057001249 S-layer homology domain; Region: SLH; pfam00395 324057001250 S-layer homology domain; Region: SLH; pfam00395 324057001251 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057001252 Chain length determinant protein; Region: Wzz; cl15801 324057001253 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057001254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057001255 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057001256 active site 324057001257 tetramer interface; other site 324057001258 Bacterial sugar transferase; Region: Bac_transf; cl00939 324057001259 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 324057001260 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 324057001261 NADP binding site [chemical binding]; other site 324057001262 active site 324057001263 putative substrate binding site [chemical binding]; other site 324057001264 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 324057001265 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324057001266 NADP-binding site; other site 324057001267 homotetramer interface [polypeptide binding]; other site 324057001268 substrate binding site [chemical binding]; other site 324057001269 homodimer interface [polypeptide binding]; other site 324057001270 active site 324057001271 putative glycosyl transferase; Provisional; Region: PRK10307 324057001272 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 324057001273 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324057001274 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057001275 trimer interface [polypeptide binding]; other site 324057001276 active site 324057001277 substrate binding site [chemical binding]; other site 324057001278 CoA binding site [chemical binding]; other site 324057001279 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057001280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057001281 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057001282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057001283 active site 324057001284 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 324057001285 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057001286 active site 324057001287 Cupin domain; Region: Cupin_2; cl09118 324057001288 MatE; Region: MatE; cl10513 324057001289 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324057001290 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057001291 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 324057001292 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057001293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001294 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057001295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001296 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057001297 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057001298 VanZ like family; Region: VanZ; cl01971 324057001299 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 324057001300 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 324057001301 active site 324057001302 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057001303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001304 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057001305 MatE; Region: MatE; cl10513 324057001306 MatE; Region: MatE; cl10513 324057001307 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 324057001308 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 324057001309 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 324057001310 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057001311 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057001312 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057001313 Walker A/P-loop; other site 324057001314 ATP binding site [chemical binding]; other site 324057001315 Q-loop/lid; other site 324057001316 ABC transporter signature motif; other site 324057001317 Walker B; other site 324057001318 D-loop; other site 324057001319 H-loop/switch region; other site 324057001320 UbiA prenyltransferase family; Region: UbiA; cl00337 324057001321 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 324057001322 Divergent PAP2 family; Region: DUF212; cl00855 324057001323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057001324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057001325 Histidine kinase; Region: His_kinase; pfam06580 324057001326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001327 ATP binding site [chemical binding]; other site 324057001328 Mg2+ binding site [ion binding]; other site 324057001329 G-X-G motif; other site 324057001330 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057001331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001332 active site 324057001333 phosphorylation site [posttranslational modification] 324057001334 intermolecular recognition site; other site 324057001335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001337 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001339 dimer interface [polypeptide binding]; other site 324057001340 conserved gate region; other site 324057001341 putative PBP binding loops; other site 324057001342 ABC-ATPase subunit interface; other site 324057001343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001344 dimer interface [polypeptide binding]; other site 324057001345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001346 ABC-ATPase subunit interface; other site 324057001347 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 324057001348 putative substrate binding site [chemical binding]; other site 324057001349 active site 324057001350 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 324057001351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001353 putative substrate translocation pore; other site 324057001354 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 324057001355 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 324057001356 putative active site [active] 324057001357 putative metal binding site [ion binding]; other site 324057001358 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057001359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057001360 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 324057001361 Helix-turn-helix domains; Region: HTH; cl00088 324057001362 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 324057001363 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 324057001364 intersubunit interface [polypeptide binding]; other site 324057001365 active site 324057001366 catalytic residue [active] 324057001367 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 324057001368 Sulfate transporter family; Region: Sulfate_transp; cl15842 324057001369 Sulfate transporter family; Region: Sulfate_transp; cl15842 324057001370 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 324057001371 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057001372 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 324057001373 active site 324057001374 catalytic residues [active] 324057001375 SurA N-terminal domain; Region: SurA_N_3; cl07813 324057001376 PPIC-type PPIASE domain; Region: Rotamase; cl08278 324057001377 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 324057001378 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 324057001379 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001380 metal binding site [ion binding]; metal-binding site 324057001381 active site 324057001382 I-site; other site 324057001383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057001384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057001385 Zn2+ binding site [ion binding]; other site 324057001386 Mg2+ binding site [ion binding]; other site 324057001387 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057001388 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001389 active site 324057001390 catalytic tetrad [active] 324057001391 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 324057001392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057001393 PAS domain S-box; Region: sensory_box; TIGR00229 324057001394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057001395 putative active site [active] 324057001396 heme pocket [chemical binding]; other site 324057001397 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057001398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057001399 putative active site [active] 324057001400 heme pocket [chemical binding]; other site 324057001401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057001402 dimer interface [polypeptide binding]; other site 324057001403 phosphorylation site [posttranslational modification] 324057001404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001405 ATP binding site [chemical binding]; other site 324057001406 Mg2+ binding site [ion binding]; other site 324057001407 G-X-G motif; other site 324057001408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001409 Response regulator receiver domain; Region: Response_reg; pfam00072 324057001410 active site 324057001411 phosphorylation site [posttranslational modification] 324057001412 intermolecular recognition site; other site 324057001413 dimerization interface [polypeptide binding]; other site 324057001414 Response regulator receiver domain; Region: Response_reg; pfam00072 324057001415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001416 active site 324057001417 phosphorylation site [posttranslational modification] 324057001418 intermolecular recognition site; other site 324057001419 dimerization interface [polypeptide binding]; other site 324057001420 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 324057001421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057001422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001423 active site 324057001424 phosphorylation site [posttranslational modification] 324057001425 intermolecular recognition site; other site 324057001426 dimerization interface [polypeptide binding]; other site 324057001427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057001428 DNA binding site [nucleotide binding] 324057001429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001430 metal binding site [ion binding]; metal-binding site 324057001431 active site 324057001432 I-site; other site 324057001433 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057001434 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324057001435 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324057001436 active site 324057001437 ATP binding site [chemical binding]; other site 324057001438 substrate binding site [chemical binding]; other site 324057001439 activation loop (A-loop); other site 324057001440 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 324057001441 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 324057001442 E-class dimer interface [polypeptide binding]; other site 324057001443 P-class dimer interface [polypeptide binding]; other site 324057001444 active site 324057001445 Cu2+ binding site [ion binding]; other site 324057001446 Zn2+ binding site [ion binding]; other site 324057001447 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057001448 nudix motif; other site 324057001449 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 324057001450 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 324057001451 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 324057001452 SpoOM protein; Region: Spo0M; pfam07070 324057001453 Predicted membrane protein [Function unknown]; Region: COG4129 324057001454 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 324057001455 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 324057001456 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 324057001457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001459 putative substrate translocation pore; other site 324057001460 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 324057001461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057001462 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057001463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001464 active site 324057001465 catalytic tetrad [active] 324057001466 threonine dehydratase; Validated; Region: PRK08639 324057001467 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 324057001468 tetramer interface [polypeptide binding]; other site 324057001469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057001470 catalytic residue [active] 324057001471 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 324057001472 putative Ile/Val binding site [chemical binding]; other site 324057001473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057001474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057001475 DNA binding site [nucleotide binding] 324057001476 domain linker motif; other site 324057001477 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001478 dimerization interface [polypeptide binding]; other site 324057001479 ligand binding site [chemical binding]; other site 324057001480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057001481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057001482 DNA binding site [nucleotide binding] 324057001483 domain linker motif; other site 324057001484 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001485 ligand binding site [chemical binding]; other site 324057001486 dimerization interface [polypeptide binding]; other site 324057001487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001488 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001491 dimer interface [polypeptide binding]; other site 324057001492 conserved gate region; other site 324057001493 putative PBP binding loops; other site 324057001494 ABC-ATPase subunit interface; other site 324057001495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057001496 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057001497 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057001498 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057001499 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057001500 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057001501 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057001502 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057001503 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057001504 oxidoreductase; Provisional; Region: PRK06196 324057001505 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 324057001506 putative NAD(P) binding site [chemical binding]; other site 324057001507 active site 324057001508 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057001509 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001511 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057001512 Cupin domain; Region: Cupin_2; cl09118 324057001513 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001515 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 324057001516 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 324057001517 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 324057001518 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 324057001519 Ligand binding site [chemical binding]; other site 324057001520 Electron transfer flavoprotein domain; Region: ETF; pfam01012 324057001521 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 324057001522 4Fe-4S binding domain; Region: Fer4; cl02805 324057001523 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 324057001524 Cysteine-rich domain; Region: CCG; pfam02754 324057001525 Cysteine-rich domain; Region: CCG; pfam02754 324057001526 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 324057001527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001528 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057001529 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057001530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324057001531 substrate binding site [chemical binding]; other site 324057001532 oxyanion hole (OAH) forming residues; other site 324057001533 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 324057001534 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324057001535 dimer interface [polypeptide binding]; other site 324057001536 active site 324057001537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324057001538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057001539 active site 324057001540 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 324057001541 AMP-binding enzyme; Region: AMP-binding; cl15778 324057001542 AMP-binding enzyme; Region: AMP-binding; cl15778 324057001543 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 324057001544 CoenzymeA binding site [chemical binding]; other site 324057001545 subunit interaction site [polypeptide binding]; other site 324057001546 PHB binding site; other site 324057001547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057001548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001549 active site 324057001550 phosphorylation site [posttranslational modification] 324057001551 intermolecular recognition site; other site 324057001552 dimerization interface [polypeptide binding]; other site 324057001553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057001554 DNA binding site [nucleotide binding] 324057001555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057001556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057001557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057001558 dimer interface [polypeptide binding]; other site 324057001559 phosphorylation site [posttranslational modification] 324057001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001561 ATP binding site [chemical binding]; other site 324057001562 Mg2+ binding site [ion binding]; other site 324057001563 G-X-G motif; other site 324057001564 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 324057001565 Moco binding site; other site 324057001566 metal coordination site [ion binding]; other site 324057001567 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 324057001568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057001569 non-specific DNA binding site [nucleotide binding]; other site 324057001570 salt bridge; other site 324057001571 sequence-specific DNA binding site [nucleotide binding]; other site 324057001572 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 324057001573 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 324057001574 active site residue [active] 324057001575 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 324057001576 active site residue [active] 324057001577 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324057001578 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324057001579 P-loop; other site 324057001580 Magnesium ion binding site [ion binding]; other site 324057001581 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324057001582 Magnesium ion binding site [ion binding]; other site 324057001583 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057001584 Cupin domain; Region: Cupin_2; cl09118 324057001585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001586 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001588 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 324057001589 putative active site [active] 324057001590 putative FMN binding site [chemical binding]; other site 324057001591 putative substrate binding site [chemical binding]; other site 324057001592 putative catalytic residue [active] 324057001593 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057001594 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057001595 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057001596 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 324057001597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057001598 active site 324057001599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057001600 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 324057001601 active site 324057001602 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 324057001603 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 324057001604 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001605 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001607 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057001610 DNA-binding site [nucleotide binding]; DNA binding site 324057001611 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001612 dimerization interface [polypeptide binding]; other site 324057001613 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057001614 ligand binding site [chemical binding]; other site 324057001615 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 324057001616 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 324057001617 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 324057001618 YCII-related domain; Region: YCII; cl00999 324057001619 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 324057001620 Cupin domain; Region: Cupin_2; cl09118 324057001621 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001623 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057001624 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 324057001625 Amidase; Region: Amidase; cl11426 324057001626 S-layer homology domain; Region: SLH; pfam00395 324057001627 S-layer homology domain; Region: SLH; pfam00395 324057001628 S-layer homology domain; Region: SLH; pfam00395 324057001629 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324057001630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057001631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057001632 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 324057001633 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057001634 putative active site [active] 324057001635 putative metal binding site [ion binding]; other site 324057001636 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 324057001637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001639 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057001640 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 324057001641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001642 dimerization interface [polypeptide binding]; other site 324057001643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057001644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057001645 dimer interface [polypeptide binding]; other site 324057001646 putative CheW interface [polypeptide binding]; other site 324057001647 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 324057001648 S-layer homology domain; Region: SLH; pfam00395 324057001649 S-layer homology domain; Region: SLH; pfam00395 324057001650 S-layer homology domain; Region: SLH; pfam00395 324057001651 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057001652 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057001653 Interdomain contacts; other site 324057001654 Cytokine receptor motif; other site 324057001655 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057001656 Interdomain contacts; other site 324057001657 Cytokine receptor motif; other site 324057001658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057001659 AAA domain; Region: AAA_22; pfam13401 324057001660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057001661 dimerization interface [polypeptide binding]; other site 324057001662 DNA binding residues [nucleotide binding] 324057001663 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 324057001664 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324057001665 Mg++ binding site [ion binding]; other site 324057001666 putative catalytic motif [active] 324057001667 substrate binding site [chemical binding]; other site 324057001668 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057001669 Helix-turn-helix domains; Region: HTH; cl00088 324057001670 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057001671 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 324057001672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057001673 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057001674 active site 324057001675 metal binding site [ion binding]; metal-binding site 324057001676 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 324057001677 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 324057001678 EamA-like transporter family; Region: EamA; cl01037 324057001679 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057001680 EamA-like transporter family; Region: EamA; cl01037 324057001681 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057001682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057001683 DNA-binding site [nucleotide binding]; DNA binding site 324057001684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057001685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057001686 homodimer interface [polypeptide binding]; other site 324057001687 catalytic residue [active] 324057001688 Cupin domain; Region: Cupin_2; cl09118 324057001689 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 324057001690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001691 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057001692 Sulfatase; Region: Sulfatase; cl10460 324057001693 Mechanosensitive ion channel; Region: MS_channel; pfam00924 324057001694 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057001695 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057001696 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324057001697 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057001698 metal binding site [ion binding]; metal-binding site 324057001699 substrate binding pocket [chemical binding]; other site 324057001700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057001701 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324057001702 substrate binding pocket [chemical binding]; other site 324057001703 Helix-turn-helix domains; Region: HTH; cl00088 324057001704 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057001705 Helix-turn-helix domains; Region: HTH; cl00088 324057001706 WYL domain; Region: WYL; cl14852 324057001707 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057001708 DinB superfamily; Region: DinB_2; pfam12867 324057001709 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057001710 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 324057001711 putative NAD(P) binding site [chemical binding]; other site 324057001712 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 324057001713 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 324057001714 putative ligand binding site [chemical binding]; other site 324057001715 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324057001716 TM-ABC transporter signature motif; other site 324057001717 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324057001718 TM-ABC transporter signature motif; other site 324057001719 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 324057001720 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 324057001721 Walker A/P-loop; other site 324057001722 ATP binding site [chemical binding]; other site 324057001723 Q-loop/lid; other site 324057001724 ABC transporter signature motif; other site 324057001725 Walker B; other site 324057001726 D-loop; other site 324057001727 H-loop/switch region; other site 324057001728 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 324057001729 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 324057001730 Walker A/P-loop; other site 324057001731 ATP binding site [chemical binding]; other site 324057001732 Q-loop/lid; other site 324057001733 ABC transporter signature motif; other site 324057001734 Walker B; other site 324057001735 D-loop; other site 324057001736 H-loop/switch region; other site 324057001737 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 324057001738 Ligand Binding Site [chemical binding]; other site 324057001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001740 dimer interface [polypeptide binding]; other site 324057001741 conserved gate region; other site 324057001742 putative PBP binding loops; other site 324057001743 ABC-ATPase subunit interface; other site 324057001744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001745 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057001747 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 324057001748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057001749 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057001750 DNA binding site [nucleotide binding] 324057001751 domain linker motif; other site 324057001752 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001753 dimerization interface [polypeptide binding]; other site 324057001754 ligand binding site [chemical binding]; other site 324057001755 YcxB-like protein; Region: YcxB; pfam14317 324057001756 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 324057001757 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 324057001758 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057001759 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057001760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057001761 Walker A/P-loop; other site 324057001762 ATP binding site [chemical binding]; other site 324057001763 Q-loop/lid; other site 324057001764 ABC transporter signature motif; other site 324057001765 Walker B; other site 324057001766 D-loop; other site 324057001767 H-loop/switch region; other site 324057001768 ABC transporter; Region: ABC_tran_2; pfam12848 324057001769 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057001770 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057001771 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057001772 Helix-turn-helix domains; Region: HTH; cl00088 324057001773 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057001774 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 324057001775 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 324057001776 DXD motif; other site 324057001777 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 324057001778 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 324057001779 Prephenate dehydratase; Region: PDT; pfam00800 324057001780 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 324057001781 putative L-Phe binding site [chemical binding]; other site 324057001782 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057001783 Helix-turn-helix domains; Region: HTH; cl00088 324057001784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057001785 Sulfatase; Region: Sulfatase; cl10460 324057001786 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 324057001787 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 324057001788 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 324057001789 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 324057001790 HPP family; Region: HPP; pfam04982 324057001791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057001792 Helix-turn-helix domains; Region: HTH; cl00088 324057001793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057001794 dimerization interface [polypeptide binding]; other site 324057001795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057001796 classical (c) SDRs; Region: SDR_c; cd05233 324057001797 NAD(P) binding site [chemical binding]; other site 324057001798 active site 324057001799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057001800 Helix-turn-helix domains; Region: HTH; cl00088 324057001801 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324057001802 Helix-turn-helix domains; Region: HTH; cl00088 324057001803 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057001804 dimer interface [polypeptide binding]; other site 324057001805 S-layer homology domain; Region: SLH; pfam00395 324057001806 S-layer homology domain; Region: SLH; pfam00395 324057001807 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 324057001808 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 324057001809 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 324057001810 trimer interface [polypeptide binding]; other site 324057001811 active site 324057001812 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 324057001813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057001814 FeS/SAM binding site; other site 324057001815 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 324057001816 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 324057001817 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057001818 NADP binding site [chemical binding]; other site 324057001819 homodimer interface [polypeptide binding]; other site 324057001820 active site 324057001821 substrate binding site [chemical binding]; other site 324057001822 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 324057001823 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057001824 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 324057001825 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 324057001826 dimer interface [polypeptide binding]; other site 324057001827 active site 324057001828 ornithine cyclodeaminase; Validated; Region: PRK08618 324057001829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001830 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001831 metal binding site [ion binding]; metal-binding site 324057001832 active site 324057001833 I-site; other site 324057001834 ApbE family; Region: ApbE; cl00643 324057001835 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 324057001836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057001837 Helix-turn-helix domains; Region: HTH; cl00088 324057001838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057001839 dimerization interface [polypeptide binding]; other site 324057001840 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 324057001841 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 324057001842 GDP-binding site [chemical binding]; other site 324057001843 ACT binding site; other site 324057001844 IMP binding site; other site 324057001845 Small acid-soluble spore protein H family; Region: SspH; cl06949 324057001846 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324057001847 EamA-like transporter family; Region: EamA; cl01037 324057001848 EamA-like transporter family; Region: EamA; cl01037 324057001849 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057001850 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057001851 sugar binding site [chemical binding]; other site 324057001852 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057001853 putative metal binding site [ion binding]; other site 324057001854 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057001855 sugar binding site [chemical binding]; other site 324057001856 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001857 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057001858 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057001859 putative metal binding site [ion binding]; other site 324057001860 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057001861 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057001862 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324057001863 Cation transport protein; Region: TrkH; cl10514 324057001864 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 324057001865 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 324057001866 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057001867 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 324057001868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057001869 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057001870 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 324057001871 putative hydrophobic ligand binding site [chemical binding]; other site 324057001872 Chromate transporter; Region: Chromate_transp; pfam02417 324057001873 Chromate transporter; Region: Chromate_transp; pfam02417 324057001874 Helix-turn-helix domains; Region: HTH; cl00088 324057001875 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057001876 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057001877 Uncharacterized conserved protein [Function unknown]; Region: COG3391 324057001878 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 324057001879 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 324057001880 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057001881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057001882 Walker A/P-loop; other site 324057001883 ATP binding site [chemical binding]; other site 324057001884 Q-loop/lid; other site 324057001885 ABC transporter signature motif; other site 324057001886 Walker B; other site 324057001887 D-loop; other site 324057001888 H-loop/switch region; other site 324057001889 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057001890 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057001891 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057001892 nudix motif; other site 324057001893 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324057001894 catalytic residues [active] 324057001895 dimer interface [polypeptide binding]; other site 324057001896 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 324057001897 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057001898 active site 324057001899 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 324057001900 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 324057001901 conserved cys residue [active] 324057001902 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 324057001903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001904 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057001905 Helix-turn-helix domains; Region: HTH; cl00088 324057001906 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 324057001907 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057001908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001909 active site 324057001910 catalytic tetrad [active] 324057001911 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057001912 Phosphotransferase enzyme family; Region: APH; pfam01636 324057001913 active site 324057001914 substrate binding site [chemical binding]; other site 324057001915 ATP binding site [chemical binding]; other site 324057001916 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057001917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057001918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001919 active site 324057001920 phosphorylation site [posttranslational modification] 324057001921 intermolecular recognition site; other site 324057001922 dimerization interface [polypeptide binding]; other site 324057001923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057001924 DNA binding residues [nucleotide binding] 324057001925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057001926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001927 ATP binding site [chemical binding]; other site 324057001928 Mg2+ binding site [ion binding]; other site 324057001929 G-X-G motif; other site 324057001930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057001931 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057001932 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001934 dimer interface [polypeptide binding]; other site 324057001935 conserved gate region; other site 324057001936 putative PBP binding loops; other site 324057001937 ABC-ATPase subunit interface; other site 324057001938 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001940 dimer interface [polypeptide binding]; other site 324057001941 conserved gate region; other site 324057001942 putative PBP binding loops; other site 324057001943 ABC-ATPase subunit interface; other site 324057001944 Sulfatase; Region: Sulfatase; cl10460 324057001945 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057001946 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057001947 putative acetyltransferase; Provisional; Region: PRK03624 324057001948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057001949 Coenzyme A binding pocket [chemical binding]; other site 324057001950 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057001951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057001952 Coenzyme A binding pocket [chemical binding]; other site 324057001953 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057001954 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001955 active site 324057001956 catalytic tetrad [active] 324057001957 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001959 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057001960 Cupin domain; Region: Cupin_2; cl09118 324057001961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001964 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 324057001965 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057001966 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057001967 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057001968 putative ligand binding residues [chemical binding]; other site 324057001969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001970 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001972 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057001973 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057001974 intersubunit interface [polypeptide binding]; other site 324057001975 WYL domain; Region: WYL; cl14852 324057001976 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 324057001977 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 324057001978 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324057001979 putative ligand binding site [chemical binding]; other site 324057001980 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 324057001981 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057001982 Walker A/P-loop; other site 324057001983 ATP binding site [chemical binding]; other site 324057001984 Q-loop/lid; other site 324057001985 ABC transporter signature motif; other site 324057001986 Walker B; other site 324057001987 D-loop; other site 324057001988 H-loop/switch region; other site 324057001989 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057001990 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057001991 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057001992 TM-ABC transporter signature motif; other site 324057001993 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057001994 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057001995 ligand binding site [chemical binding]; other site 324057001996 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057001997 Cache domain; Region: Cache_1; pfam02743 324057001998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001999 dimerization interface [polypeptide binding]; other site 324057002000 Histidine kinase; Region: His_kinase; pfam06580 324057002001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002002 ATP binding site [chemical binding]; other site 324057002003 Mg2+ binding site [ion binding]; other site 324057002004 G-X-G motif; other site 324057002005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002006 active site 324057002007 phosphorylation site [posttranslational modification] 324057002008 intermolecular recognition site; other site 324057002009 dimerization interface [polypeptide binding]; other site 324057002010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057002013 Helix-turn-helix domains; Region: HTH; cl00088 324057002014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057002015 dimerization interface [polypeptide binding]; other site 324057002016 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 324057002017 active site residue [active] 324057002018 Protein of unknown function (DUF975); Region: DUF975; cl10504 324057002019 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057002020 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057002021 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057002022 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002024 dimerization interface [polypeptide binding]; other site 324057002025 Histidine kinase; Region: His_kinase; pfam06580 324057002026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002027 ATP binding site [chemical binding]; other site 324057002028 Mg2+ binding site [ion binding]; other site 324057002029 G-X-G motif; other site 324057002030 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002032 active site 324057002033 phosphorylation site [posttranslational modification] 324057002034 intermolecular recognition site; other site 324057002035 dimerization interface [polypeptide binding]; other site 324057002036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002039 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002042 dimer interface [polypeptide binding]; other site 324057002043 conserved gate region; other site 324057002044 putative PBP binding loops; other site 324057002045 ABC-ATPase subunit interface; other site 324057002046 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002048 dimer interface [polypeptide binding]; other site 324057002049 conserved gate region; other site 324057002050 ABC-ATPase subunit interface; other site 324057002051 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057002052 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057002053 Interdomain contacts; other site 324057002054 Cytokine receptor motif; other site 324057002055 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057002056 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057002057 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057002058 S-layer homology domain; Region: SLH; pfam00395 324057002059 S-layer homology domain; Region: SLH; pfam00395 324057002060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057002061 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057002062 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057002063 Metal-binding active site; metal-binding site 324057002064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057002065 DNA-binding site [nucleotide binding]; DNA binding site 324057002066 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057002067 dimerization interface [polypeptide binding]; other site 324057002068 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057002069 ligand binding site [chemical binding]; other site 324057002070 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002073 dimer interface [polypeptide binding]; other site 324057002074 conserved gate region; other site 324057002075 putative PBP binding loops; other site 324057002076 ABC-ATPase subunit interface; other site 324057002077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002079 dimer interface [polypeptide binding]; other site 324057002080 conserved gate region; other site 324057002081 putative PBP binding loops; other site 324057002082 ABC-ATPase subunit interface; other site 324057002083 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057002084 active site 324057002085 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002086 Transcription factor Tfb2; Region: Tfb2; cl04289 324057002087 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002089 active site 324057002090 phosphorylation site [posttranslational modification] 324057002091 intermolecular recognition site; other site 324057002092 dimerization interface [polypeptide binding]; other site 324057002093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002095 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 324057002096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057002097 Histidine kinase; Region: His_kinase; pfam06580 324057002098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002099 ATP binding site [chemical binding]; other site 324057002100 Mg2+ binding site [ion binding]; other site 324057002101 G-X-G motif; other site 324057002102 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002104 dimer interface [polypeptide binding]; other site 324057002105 conserved gate region; other site 324057002106 ABC-ATPase subunit interface; other site 324057002107 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057002109 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057002110 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057002111 putative ligand binding residues [chemical binding]; other site 324057002112 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002113 ABC-ATPase subunit interface; other site 324057002114 dimer interface [polypeptide binding]; other site 324057002115 putative PBP binding regions; other site 324057002116 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057002117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002118 ABC-ATPase subunit interface; other site 324057002119 dimer interface [polypeptide binding]; other site 324057002120 putative PBP binding regions; other site 324057002121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002122 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002124 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057002125 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057002126 siderophore binding site; other site 324057002127 Protein of unknown function (DUF975); Region: DUF975; cl10504 324057002128 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 324057002129 Ca2+ binding site [ion binding]; other site 324057002130 VCBS repeat; Region: VCBS_repeat; TIGR01965 324057002131 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 324057002132 Ca2+ binding site [ion binding]; other site 324057002133 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057002134 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057002135 S-layer homology domain; Region: SLH; pfam00395 324057002136 S-layer homology domain; Region: SLH; pfam00395 324057002137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057002138 Helix-turn-helix domains; Region: HTH; cl00088 324057002139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057002140 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 324057002141 Walker A/P-loop; other site 324057002142 ATP binding site [chemical binding]; other site 324057002143 Q-loop/lid; other site 324057002144 ABC transporter signature motif; other site 324057002145 Walker B; other site 324057002146 D-loop; other site 324057002147 H-loop/switch region; other site 324057002148 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057002149 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057002150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002151 Coenzyme A binding pocket [chemical binding]; other site 324057002152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057002153 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057002154 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057002155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002156 putative substrate translocation pore; other site 324057002157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057002158 PAS domain S-box; Region: sensory_box; TIGR00229 324057002159 Mnd1 family; Region: Mnd1; pfam03962 324057002160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057002161 metal binding site [ion binding]; metal-binding site 324057002162 active site 324057002163 I-site; other site 324057002164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057002165 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057002166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002168 tyramine oxidase; Provisional; Region: tynA; PRK14696 324057002169 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057002170 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 324057002171 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 324057002172 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 324057002173 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057002174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002175 Coenzyme A binding pocket [chemical binding]; other site 324057002176 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057002177 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057002178 Zn2+ binding site [ion binding]; other site 324057002179 Mg2+ binding site [ion binding]; other site 324057002180 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057002181 active site 324057002182 metal binding site [ion binding]; metal-binding site 324057002183 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057002184 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057002185 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057002186 Walker A/P-loop; other site 324057002187 ATP binding site [chemical binding]; other site 324057002188 Q-loop/lid; other site 324057002189 ABC transporter signature motif; other site 324057002190 Walker B; other site 324057002191 D-loop; other site 324057002192 H-loop/switch region; other site 324057002193 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057002194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057002195 Histidine kinase; Region: HisKA_3; pfam07730 324057002196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057002197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057002198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002199 active site 324057002200 phosphorylation site [posttranslational modification] 324057002201 intermolecular recognition site; other site 324057002202 dimerization interface [polypeptide binding]; other site 324057002203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057002204 DNA binding residues [nucleotide binding] 324057002205 dimerization interface [polypeptide binding]; other site 324057002206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002207 Coenzyme A binding pocket [chemical binding]; other site 324057002208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057002209 Helix-turn-helix domains; Region: HTH; cl00088 324057002210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057002211 dimerization interface [polypeptide binding]; other site 324057002212 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 324057002213 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 324057002214 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057002215 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 324057002216 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002217 Histidine kinase; Region: His_kinase; pfam06580 324057002218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002219 ATP binding site [chemical binding]; other site 324057002220 Mg2+ binding site [ion binding]; other site 324057002221 G-X-G motif; other site 324057002222 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002224 active site 324057002225 phosphorylation site [posttranslational modification] 324057002226 intermolecular recognition site; other site 324057002227 dimerization interface [polypeptide binding]; other site 324057002228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002229 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002231 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002233 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002235 dimer interface [polypeptide binding]; other site 324057002236 conserved gate region; other site 324057002237 putative PBP binding loops; other site 324057002238 ABC-ATPase subunit interface; other site 324057002239 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002241 dimer interface [polypeptide binding]; other site 324057002242 conserved gate region; other site 324057002243 putative PBP binding loops; other site 324057002244 ABC-ATPase subunit interface; other site 324057002245 ThiC-associated domain; Region: ThiC-associated; pfam13667 324057002246 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 324057002247 ThiC family; Region: ThiC; cl08031 324057002248 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057002249 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 324057002250 putative NAD(P) binding site [chemical binding]; other site 324057002251 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 324057002252 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 324057002253 generic binding surface I; other site 324057002254 generic binding surface II; other site 324057002255 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057002256 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057002257 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057002258 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057002259 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057002260 RDD family; Region: RDD; cl00746 324057002261 Cupin domain; Region: Cupin_2; cl09118 324057002262 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057002265 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057002266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057002268 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057002269 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 324057002270 Histidine kinase; Region: His_kinase; pfam06580 324057002271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002272 ATP binding site [chemical binding]; other site 324057002273 Mg2+ binding site [ion binding]; other site 324057002274 G-X-G motif; other site 324057002275 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002277 active site 324057002278 phosphorylation site [posttranslational modification] 324057002279 intermolecular recognition site; other site 324057002280 dimerization interface [polypeptide binding]; other site 324057002281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002282 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057002283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002284 dimer interface [polypeptide binding]; other site 324057002285 conserved gate region; other site 324057002286 ABC-ATPase subunit interface; other site 324057002287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057002289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002290 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057002291 Right handed beta helix region; Region: Beta_helix; pfam13229 324057002292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057002293 TPR motif; other site 324057002294 binding surface 324057002295 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057002296 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 324057002297 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057002298 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057002299 inhibitor binding site; inhibition site 324057002300 active site 324057002301 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 324057002302 Cupin domain; Region: Cupin_2; cl09118 324057002303 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057002304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002305 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057002306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002307 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 324057002308 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057002309 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 324057002310 active site 324057002311 putative catalytic site [active] 324057002312 DNA binding site [nucleotide binding] 324057002313 putative phosphate binding site [ion binding]; other site 324057002314 metal binding site A [ion binding]; metal-binding site 324057002315 AP binding site [nucleotide binding]; other site 324057002316 metal binding site B [ion binding]; metal-binding site 324057002317 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 324057002318 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 324057002319 active site 324057002320 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057002321 EamA-like transporter family; Region: EamA; cl01037 324057002322 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057002323 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057002324 Walker A/P-loop; other site 324057002325 ATP binding site [chemical binding]; other site 324057002326 Q-loop/lid; other site 324057002327 ABC transporter signature motif; other site 324057002328 Walker B; other site 324057002329 D-loop; other site 324057002330 H-loop/switch region; other site 324057002331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002332 dimer interface [polypeptide binding]; other site 324057002333 conserved gate region; other site 324057002334 putative PBP binding loops; other site 324057002335 ABC-ATPase subunit interface; other site 324057002336 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 324057002337 active site 324057002338 catalytic site [active] 324057002339 substrate binding site [chemical binding]; other site 324057002340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057002341 Helix-turn-helix domains; Region: HTH; cl00088 324057002342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057002343 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057002344 substrate binding pocket [chemical binding]; other site 324057002345 membrane-bound complex binding site; other site 324057002346 hinge residues; other site 324057002347 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 324057002348 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 324057002349 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 324057002350 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 324057002351 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 324057002352 active site 324057002353 intersubunit interface [polypeptide binding]; other site 324057002354 catalytic residue [active] 324057002355 fumarate hydratase; Reviewed; Region: fumC; PRK00485 324057002356 Class II fumarases; Region: Fumarase_classII; cd01362 324057002357 active site 324057002358 tetramer interface [polypeptide binding]; other site 324057002359 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057002360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057002361 Walker A/P-loop; other site 324057002362 ATP binding site [chemical binding]; other site 324057002363 Q-loop/lid; other site 324057002364 ABC transporter signature motif; other site 324057002365 Walker B; other site 324057002366 D-loop; other site 324057002367 H-loop/switch region; other site 324057002368 ABC transporter; Region: ABC_tran_2; pfam12848 324057002369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057002370 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 324057002371 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057002372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002373 putative substrate translocation pore; other site 324057002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002375 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324057002376 Ferritin-like domain; Region: Ferritin; pfam00210 324057002377 dimerization interface [polypeptide binding]; other site 324057002378 DPS ferroxidase diiron center [ion binding]; other site 324057002379 ion pore; other site 324057002380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057002381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057002382 DNA binding site [nucleotide binding] 324057002383 domain linker motif; other site 324057002384 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 324057002385 putative dimerization interface [polypeptide binding]; other site 324057002386 putative ligand binding site [chemical binding]; other site 324057002387 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 324057002388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002390 dimer interface [polypeptide binding]; other site 324057002391 conserved gate region; other site 324057002392 ABC-ATPase subunit interface; other site 324057002393 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 324057002394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002395 dimer interface [polypeptide binding]; other site 324057002396 conserved gate region; other site 324057002397 putative PBP binding loops; other site 324057002398 ABC-ATPase subunit interface; other site 324057002399 trehalose synthase; Region: treS_nterm; TIGR02456 324057002400 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 324057002401 Ca binding site [ion binding]; other site 324057002402 active site 324057002403 catalytic site [active] 324057002404 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 324057002405 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002407 active site 324057002408 phosphorylation site [posttranslational modification] 324057002409 intermolecular recognition site; other site 324057002410 dimerization interface [polypeptide binding]; other site 324057002411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002414 dimerization interface [polypeptide binding]; other site 324057002415 Histidine kinase; Region: His_kinase; pfam06580 324057002416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002417 ATP binding site [chemical binding]; other site 324057002418 Mg2+ binding site [ion binding]; other site 324057002419 G-X-G motif; other site 324057002420 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002422 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002424 putative PBP binding loops; other site 324057002425 dimer interface [polypeptide binding]; other site 324057002426 ABC-ATPase subunit interface; other site 324057002427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002428 dimer interface [polypeptide binding]; other site 324057002429 conserved gate region; other site 324057002430 putative PBP binding loops; other site 324057002431 ABC-ATPase subunit interface; other site 324057002432 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057002433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057002434 NAD(P) binding site [chemical binding]; other site 324057002435 active site 324057002436 galactonate dehydratase; Provisional; Region: PRK14017 324057002437 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 324057002438 putative active site pocket [active] 324057002439 putative metal binding site [ion binding]; other site 324057002440 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324057002441 homodimer interface [polypeptide binding]; other site 324057002442 maltodextrin glucosidase; Provisional; Region: PRK10785 324057002443 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324057002444 active site 324057002445 homodimer interface [polypeptide binding]; other site 324057002446 catalytic site [active] 324057002447 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 324057002448 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324057002449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057002450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057002451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057002452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002453 active site 324057002454 phosphorylation site [posttranslational modification] 324057002455 intermolecular recognition site; other site 324057002456 dimerization interface [polypeptide binding]; other site 324057002457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057002458 DNA binding site [nucleotide binding] 324057002459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002461 dimerization interface [polypeptide binding]; other site 324057002462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057002463 dimer interface [polypeptide binding]; other site 324057002464 phosphorylation site [posttranslational modification] 324057002465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002466 ATP binding site [chemical binding]; other site 324057002467 Mg2+ binding site [ion binding]; other site 324057002468 G-X-G motif; other site 324057002469 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057002470 active site 324057002471 tetramer interface; other site 324057002472 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057002473 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057002474 Walker A/P-loop; other site 324057002475 ATP binding site [chemical binding]; other site 324057002476 Q-loop/lid; other site 324057002477 ABC transporter signature motif; other site 324057002478 Walker B; other site 324057002479 D-loop; other site 324057002480 H-loop/switch region; other site 324057002481 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057002482 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057002483 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002484 ABC-ATPase subunit interface; other site 324057002485 dimer interface [polypeptide binding]; other site 324057002486 putative PBP binding regions; other site 324057002487 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002488 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057002489 intersubunit interface [polypeptide binding]; other site 324057002490 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057002491 heme-binding site [chemical binding]; other site 324057002492 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057002493 heme-binding site [chemical binding]; other site 324057002494 S-layer homology domain; Region: SLH; pfam00395 324057002495 S-layer homology domain; Region: SLH; pfam00395 324057002496 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 324057002497 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002498 intersubunit interface [polypeptide binding]; other site 324057002499 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057002500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002501 ABC-ATPase subunit interface; other site 324057002502 dimer interface [polypeptide binding]; other site 324057002503 putative PBP binding regions; other site 324057002504 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057002505 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057002506 Walker A/P-loop; other site 324057002507 ATP binding site [chemical binding]; other site 324057002508 Q-loop/lid; other site 324057002509 ABC transporter signature motif; other site 324057002510 Walker B; other site 324057002511 D-loop; other site 324057002512 H-loop/switch region; other site 324057002513 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 324057002514 superoxide dismutase; Provisional; Region: PRK10925 324057002515 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 324057002516 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 324057002517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002518 Coenzyme A binding pocket [chemical binding]; other site 324057002519 Protein of unknown function (DUF402); Region: DUF402; cl00979 324057002520 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324057002521 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324057002522 Catalytic site [active] 324057002523 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 324057002524 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057002525 active site 324057002526 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 324057002527 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 324057002528 HEAT repeats; Region: HEAT_2; pfam13646 324057002529 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 324057002530 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 324057002531 homodecamer interface [polypeptide binding]; other site 324057002532 GTP cyclohydrolase I; Provisional; Region: PLN03044 324057002533 active site 324057002534 putative catalytic site residues [active] 324057002535 zinc binding site [ion binding]; other site 324057002536 GTP-CH-I/GFRP interaction surface; other site 324057002537 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 324057002538 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324057002539 nucleophilic elbow; other site 324057002540 catalytic triad; other site 324057002541 Transcriptional regulator [Transcription]; Region: IclR; COG1414 324057002542 Helix-turn-helix domains; Region: HTH; cl00088 324057002543 Bacterial transcriptional regulator; Region: IclR; pfam01614 324057002544 aconitate hydratase; Validated; Region: PRK09277 324057002545 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 324057002546 substrate binding site [chemical binding]; other site 324057002547 ligand binding site [chemical binding]; other site 324057002548 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 324057002549 substrate binding site [chemical binding]; other site 324057002550 NlpC/P60 family; Region: NLPC_P60; cl11438 324057002551 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 324057002552 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324057002553 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057002554 UV-endonuclease UvdE; Region: UvdE; cl10036 324057002555 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 324057002556 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 324057002557 active site 324057002558 dimerization interface [polypeptide binding]; other site 324057002559 S-layer homology domain; Region: SLH; pfam00395 324057002560 S-layer homology domain; Region: SLH; pfam00395 324057002561 S-layer homology domain; Region: SLH; pfam00395 324057002562 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002564 active site 324057002565 phosphorylation site [posttranslational modification] 324057002566 intermolecular recognition site; other site 324057002567 dimerization interface [polypeptide binding]; other site 324057002568 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057002572 Histidine kinase; Region: His_kinase; pfam06580 324057002573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002574 ATP binding site [chemical binding]; other site 324057002575 Mg2+ binding site [ion binding]; other site 324057002576 G-X-G motif; other site 324057002577 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002579 dimer interface [polypeptide binding]; other site 324057002580 conserved gate region; other site 324057002581 ABC-ATPase subunit interface; other site 324057002582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002583 dimer interface [polypeptide binding]; other site 324057002584 conserved gate region; other site 324057002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057002586 ABC-ATPase subunit interface; other site 324057002587 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002589 S-layer homology domain; Region: SLH; pfam00395 324057002590 S-layer homology domain; Region: SLH; pfam00395 324057002591 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324057002592 active site 324057002593 catalytic residues [active] 324057002594 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002595 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002596 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002597 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002598 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324057002599 active site 324057002600 catalytic residues [active] 324057002601 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002602 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002603 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002604 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002605 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002606 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057002607 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002608 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057002609 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 324057002610 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057002611 inhibitor-cofactor binding pocket; inhibition site 324057002612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057002613 catalytic residue [active] 324057002614 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324057002615 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057002616 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 324057002617 Walker A/P-loop; other site 324057002618 ATP binding site [chemical binding]; other site 324057002619 Q-loop/lid; other site 324057002620 ABC transporter signature motif; other site 324057002621 Walker B; other site 324057002622 D-loop; other site 324057002623 H-loop/switch region; other site 324057002624 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057002625 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057002626 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057002627 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057002628 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 324057002629 catalytic triad [active] 324057002630 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 324057002631 NodB motif; other site 324057002632 active site 324057002633 catalytic site [active] 324057002634 Zn binding site [ion binding]; other site 324057002635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057002636 Walker A motif; other site 324057002637 ATP binding site [chemical binding]; other site 324057002638 Walker B motif; other site 324057002639 arginine finger; other site 324057002640 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 324057002641 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324057002642 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057002643 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324057002644 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057002645 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324057002646 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 324057002647 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057002648 NodB motif; other site 324057002649 active site 324057002650 catalytic site [active] 324057002651 metal binding site [ion binding]; metal-binding site 324057002652 GMP synthase; Reviewed; Region: guaA; PRK00074 324057002653 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 324057002654 AMP/PPi binding site [chemical binding]; other site 324057002655 candidate oxyanion hole; other site 324057002656 catalytic triad [active] 324057002657 potential glutamine specificity residues [chemical binding]; other site 324057002658 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 324057002659 ATP Binding subdomain [chemical binding]; other site 324057002660 Ligand Binding sites [chemical binding]; other site 324057002661 Dimerization subdomain; other site 324057002662 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 324057002663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002664 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057002665 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057002666 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057002667 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057002668 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057002670 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057002671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057002672 Histidine kinase; Region: His_kinase; pfam06580 324057002673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002674 ATP binding site [chemical binding]; other site 324057002675 Mg2+ binding site [ion binding]; other site 324057002676 G-X-G motif; other site 324057002677 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002679 active site 324057002680 phosphorylation site [posttranslational modification] 324057002681 intermolecular recognition site; other site 324057002682 dimerization interface [polypeptide binding]; other site 324057002683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002684 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002686 dimer interface [polypeptide binding]; other site 324057002687 conserved gate region; other site 324057002688 ABC-ATPase subunit interface; other site 324057002689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002691 dimer interface [polypeptide binding]; other site 324057002692 conserved gate region; other site 324057002693 ABC-ATPase subunit interface; other site 324057002694 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002696 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057002697 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057002698 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057002699 S-layer homology domain; Region: SLH; pfam00395 324057002700 S-layer homology domain; Region: SLH; pfam00395 324057002701 S-layer homology domain; Region: SLH; pfam00395 324057002702 Cupin domain; Region: Cupin_2; cl09118 324057002703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002706 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 324057002707 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057002708 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 324057002709 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 324057002710 NAD binding site [chemical binding]; other site 324057002711 sugar binding site [chemical binding]; other site 324057002712 divalent metal binding site [ion binding]; other site 324057002713 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057002714 dimer interface [polypeptide binding]; other site 324057002715 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324057002716 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057002717 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 324057002718 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 324057002719 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 324057002720 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 324057002721 putative FMN binding site [chemical binding]; other site 324057002722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057002723 Helix-turn-helix domains; Region: HTH; cl00088 324057002724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057002725 Helix-turn-helix domains; Region: HTH; cl00088 324057002726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057002728 putative substrate translocation pore; other site 324057002729 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 324057002730 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057002731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057002732 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 324057002733 active site 324057002734 AIR carboxylase; Region: AIRC; cl00310 324057002735 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 324057002736 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057002737 adenylosuccinate lyase; Provisional; Region: PRK07492 324057002738 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 324057002739 tetramer interface [polypeptide binding]; other site 324057002740 active site 324057002741 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 324057002742 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 324057002743 ATP binding site [chemical binding]; other site 324057002744 active site 324057002745 substrate binding site [chemical binding]; other site 324057002746 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 324057002747 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 324057002748 putative active site [active] 324057002749 catalytic triad [active] 324057002750 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 324057002751 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 324057002752 dimerization interface [polypeptide binding]; other site 324057002753 ATP binding site [chemical binding]; other site 324057002754 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 324057002755 dimerization interface [polypeptide binding]; other site 324057002756 ATP binding site [chemical binding]; other site 324057002757 amidophosphoribosyltransferase; Provisional; Region: PRK07272 324057002758 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 324057002759 active site 324057002760 tetramer interface [polypeptide binding]; other site 324057002761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057002762 active site 324057002763 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 324057002764 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 324057002765 dimerization interface [polypeptide binding]; other site 324057002766 putative ATP binding site [chemical binding]; other site 324057002767 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 324057002768 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 324057002769 active site 324057002770 substrate binding site [chemical binding]; other site 324057002771 cosubstrate binding site; other site 324057002772 catalytic site [active] 324057002773 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 324057002774 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 324057002775 purine monophosphate binding site [chemical binding]; other site 324057002776 dimer interface [polypeptide binding]; other site 324057002777 putative catalytic residues [active] 324057002778 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 324057002779 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 324057002780 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 324057002781 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 324057002782 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057002783 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 324057002784 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057002785 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057002786 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 324057002787 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 324057002788 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 324057002789 Phosphate transporter family; Region: PHO4; cl00396 324057002790 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 324057002791 Helix-turn-helix domains; Region: HTH; cl00088 324057002792 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 324057002793 putative active site [active] 324057002794 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 324057002795 putative active site [active] 324057002796 putative lipid kinase; Reviewed; Region: PRK13337 324057002797 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 324057002798 TRAM domain; Region: TRAM; cl01282 324057002799 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 324057002800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057002801 S-adenosylmethionine binding site [chemical binding]; other site 324057002802 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 324057002803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057002805 dimer interface [polypeptide binding]; other site 324057002806 phosphorylation site [posttranslational modification] 324057002807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002808 ATP binding site [chemical binding]; other site 324057002809 Mg2+ binding site [ion binding]; other site 324057002810 G-X-G motif; other site 324057002811 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002813 active site 324057002814 phosphorylation site [posttranslational modification] 324057002815 intermolecular recognition site; other site 324057002816 dimerization interface [polypeptide binding]; other site 324057002817 Histidine kinase; Region: His_kinase; pfam06580 324057002818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002819 ATP binding site [chemical binding]; other site 324057002820 Mg2+ binding site [ion binding]; other site 324057002821 G-X-G motif; other site 324057002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002823 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002824 active site 324057002825 phosphorylation site [posttranslational modification] 324057002826 intermolecular recognition site; other site 324057002827 dimerization interface [polypeptide binding]; other site 324057002828 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 324057002829 Helix-turn-helix domains; Region: HTH; cl00088 324057002830 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 324057002831 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057002832 S-layer homology domain; Region: SLH; pfam00395 324057002833 S-layer homology domain; Region: SLH; pfam00395 324057002834 S-layer homology domain; Region: SLH; pfam00395 324057002835 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057002836 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057002837 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057002838 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057002839 inhibitor binding site; inhibition site 324057002840 active site 324057002841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002843 dimer interface [polypeptide binding]; other site 324057002844 conserved gate region; other site 324057002845 putative PBP binding loops; other site 324057002846 ABC-ATPase subunit interface; other site 324057002847 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002849 dimer interface [polypeptide binding]; other site 324057002850 conserved gate region; other site 324057002851 putative PBP binding loops; other site 324057002852 ABC-ATPase subunit interface; other site 324057002853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057002854 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057002855 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057002856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002857 dimerization interface [polypeptide binding]; other site 324057002858 Histidine kinase; Region: His_kinase; pfam06580 324057002859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002860 ATP binding site [chemical binding]; other site 324057002861 Mg2+ binding site [ion binding]; other site 324057002862 G-X-G motif; other site 324057002863 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002865 active site 324057002866 phosphorylation site [posttranslational modification] 324057002867 intermolecular recognition site; other site 324057002868 dimerization interface [polypeptide binding]; other site 324057002869 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002871 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057002872 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057002873 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057002874 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 324057002875 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 324057002876 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 324057002877 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 324057002878 homodimer interface [polypeptide binding]; other site 324057002879 NADP binding site [chemical binding]; other site 324057002880 substrate binding site [chemical binding]; other site 324057002881 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057002882 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057002883 putative active site [active] 324057002884 putative metal binding site [ion binding]; other site 324057002885 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057002886 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057002887 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057002888 Walker A/P-loop; other site 324057002889 ATP binding site [chemical binding]; other site 324057002890 Q-loop/lid; other site 324057002891 ABC transporter signature motif; other site 324057002892 Walker B; other site 324057002893 D-loop; other site 324057002894 H-loop/switch region; other site 324057002895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057002896 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057002897 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057002898 Walker A/P-loop; other site 324057002899 ATP binding site [chemical binding]; other site 324057002900 Q-loop/lid; other site 324057002901 ABC transporter signature motif; other site 324057002902 Walker B; other site 324057002903 D-loop; other site 324057002904 H-loop/switch region; other site 324057002905 aminoglycoside resistance protein; Provisional; Region: PRK13746 324057002906 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324057002907 active site 324057002908 NTP binding site [chemical binding]; other site 324057002909 metal binding triad [ion binding]; metal-binding site 324057002910 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 324057002911 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 324057002912 active site 324057002913 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002915 active site 324057002916 phosphorylation site [posttranslational modification] 324057002917 intermolecular recognition site; other site 324057002918 dimerization interface [polypeptide binding]; other site 324057002919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002923 dimerization interface [polypeptide binding]; other site 324057002924 Histidine kinase; Region: His_kinase; pfam06580 324057002925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002926 ATP binding site [chemical binding]; other site 324057002927 Mg2+ binding site [ion binding]; other site 324057002928 G-X-G motif; other site 324057002929 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002930 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057002931 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057002933 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002935 dimer interface [polypeptide binding]; other site 324057002936 conserved gate region; other site 324057002937 putative PBP binding loops; other site 324057002938 ABC-ATPase subunit interface; other site 324057002939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002940 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057002941 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057002942 catalytic core [active] 324057002943 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 324057002944 Domain of unknown function DUF20; Region: UPF0118; pfam01594 324057002945 Spore germination protein; Region: Spore_permease; cl15802 324057002946 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057002947 Spore germination protein; Region: Spore_permease; cl15802 324057002948 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057002949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057002950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 324057002951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 324057002952 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 324057002953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057002955 putative substrate translocation pore; other site 324057002956 Cupin domain; Region: Cupin_2; cl09118 324057002957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002960 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 324057002961 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057002962 DNA binding residues [nucleotide binding] 324057002963 putative dimer interface [polypeptide binding]; other site 324057002964 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057002965 catalytic residues [active] 324057002966 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 324057002967 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057002968 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057002969 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002970 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324057002971 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057002972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002974 dimer interface [polypeptide binding]; other site 324057002975 conserved gate region; other site 324057002976 putative PBP binding loops; other site 324057002977 ABC-ATPase subunit interface; other site 324057002978 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002980 dimer interface [polypeptide binding]; other site 324057002981 conserved gate region; other site 324057002982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057002983 ABC-ATPase subunit interface; other site 324057002984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002986 Right handed beta helix region; Region: Beta_helix; pfam13229 324057002987 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057002988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002989 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057002990 putative substrate translocation pore; other site 324057002991 Helix-turn-helix domains; Region: HTH; cl00088 324057002992 histidyl-tRNA synthetase; Provisional; Region: PRK12420 324057002993 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 324057002994 dimer interface [polypeptide binding]; other site 324057002995 motif 1; other site 324057002996 active site 324057002997 motif 2; other site 324057002998 motif 3; other site 324057002999 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 324057003000 anticodon binding site; other site 324057003001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057003002 non-specific DNA binding site [nucleotide binding]; other site 324057003003 salt bridge; other site 324057003004 sequence-specific DNA binding site [nucleotide binding]; other site 324057003005 tellurite resistance protein TehB; Provisional; Region: PRK11207 324057003006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057003007 S-adenosylmethionine binding site [chemical binding]; other site 324057003008 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 324057003009 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324057003010 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057003011 Protein of unknown function (DUF419); Region: DUF419; cl15265 324057003012 dihydroorotase; Provisional; Region: PRK09237 324057003013 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057003014 active site 324057003015 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 324057003016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057003017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057003018 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057003019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057003020 catalytic residue [active] 324057003021 catalytic residue [active] 324057003022 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 324057003023 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057003024 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 324057003025 substrate binding site [chemical binding]; other site 324057003026 ATP binding site [chemical binding]; other site 324057003027 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057003028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057003029 DNA-binding site [nucleotide binding]; DNA binding site 324057003030 UTRA domain; Region: UTRA; cl01230 324057003031 Protein of unknown function (DUF419); Region: DUF419; cl15265 324057003032 Predicted acetyltransferase [General function prediction only]; Region: COG3981 324057003033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057003034 Coenzyme A binding pocket [chemical binding]; other site 324057003035 DinB superfamily; Region: DinB_2; pfam12867 324057003036 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057003037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003038 active site 324057003039 phosphorylation site [posttranslational modification] 324057003040 intermolecular recognition site; other site 324057003041 dimerization interface [polypeptide binding]; other site 324057003042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057003044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003045 dimerization interface [polypeptide binding]; other site 324057003046 Histidine kinase; Region: His_kinase; pfam06580 324057003047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003048 ATP binding site [chemical binding]; other site 324057003049 Mg2+ binding site [ion binding]; other site 324057003050 G-X-G motif; other site 324057003051 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003053 dimer interface [polypeptide binding]; other site 324057003054 conserved gate region; other site 324057003055 ABC-ATPase subunit interface; other site 324057003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003057 dimer interface [polypeptide binding]; other site 324057003058 conserved gate region; other site 324057003059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057003060 ABC-ATPase subunit interface; other site 324057003061 S-layer homology domain; Region: SLH; pfam00395 324057003062 S-layer homology domain; Region: SLH; pfam00395 324057003063 S-layer homology domain; Region: SLH; pfam00395 324057003064 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324057003065 active site 324057003066 catalytic residues [active] 324057003067 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003068 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003069 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057003070 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003071 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003072 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 324057003073 active site 324057003074 active site 324057003075 catalytic residues [active] 324057003076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003077 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057003078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003079 dimerization interface [polypeptide binding]; other site 324057003080 Histidine kinase; Region: His_kinase; pfam06580 324057003081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003082 ATP binding site [chemical binding]; other site 324057003083 Mg2+ binding site [ion binding]; other site 324057003084 G-X-G motif; other site 324057003085 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057003086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003087 active site 324057003088 phosphorylation site [posttranslational modification] 324057003089 intermolecular recognition site; other site 324057003090 dimerization interface [polypeptide binding]; other site 324057003091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003093 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003095 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003097 dimer interface [polypeptide binding]; other site 324057003098 conserved gate region; other site 324057003099 ABC-ATPase subunit interface; other site 324057003100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003101 dimer interface [polypeptide binding]; other site 324057003102 conserved gate region; other site 324057003103 putative PBP binding loops; other site 324057003104 ABC-ATPase subunit interface; other site 324057003105 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057003106 Sulfatase; Region: Sulfatase; cl10460 324057003107 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 324057003108 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324057003109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003110 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057003111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003112 dimer interface [polypeptide binding]; other site 324057003113 conserved gate region; other site 324057003114 putative PBP binding loops; other site 324057003115 ABC-ATPase subunit interface; other site 324057003116 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 324057003117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003118 dimer interface [polypeptide binding]; other site 324057003119 conserved gate region; other site 324057003120 putative PBP binding loops; other site 324057003121 ABC-ATPase subunit interface; other site 324057003122 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057003123 putative metal binding site [ion binding]; other site 324057003124 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057003125 putative metal binding site [ion binding]; other site 324057003126 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057003127 Right handed beta helix region; Region: Beta_helix; pfam13229 324057003128 S-layer homology domain; Region: SLH; pfam00395 324057003129 S-layer homology domain; Region: SLH; pfam00395 324057003130 S-layer homology domain; Region: SLH; pfam00395 324057003131 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003132 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003135 dimerization interface [polypeptide binding]; other site 324057003136 Histidine kinase; Region: His_kinase; pfam06580 324057003137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003138 ATP binding site [chemical binding]; other site 324057003139 Mg2+ binding site [ion binding]; other site 324057003140 G-X-G motif; other site 324057003141 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057003142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003143 active site 324057003144 phosphorylation site [posttranslational modification] 324057003145 intermolecular recognition site; other site 324057003146 dimerization interface [polypeptide binding]; other site 324057003147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003148 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057003149 Spore germination protein; Region: Spore_permease; cl15802 324057003150 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057003151 CAAX protease self-immunity; Region: Abi; cl00558 324057003152 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057003153 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057003154 ligand binding site [chemical binding]; other site 324057003155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003156 dimerization interface [polypeptide binding]; other site 324057003157 Histidine kinase; Region: His_kinase; pfam06580 324057003158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057003159 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057003160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003161 active site 324057003162 phosphorylation site [posttranslational modification] 324057003163 intermolecular recognition site; other site 324057003164 dimerization interface [polypeptide binding]; other site 324057003165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003166 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 324057003167 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324057003168 putative ligand binding site [chemical binding]; other site 324057003169 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 324057003170 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324057003171 putative ligand binding site [chemical binding]; other site 324057003172 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 324057003173 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057003174 Walker A/P-loop; other site 324057003175 ATP binding site [chemical binding]; other site 324057003176 Q-loop/lid; other site 324057003177 ABC transporter signature motif; other site 324057003178 Walker B; other site 324057003179 D-loop; other site 324057003180 H-loop/switch region; other site 324057003181 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057003182 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 324057003183 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057003184 TM-ABC transporter signature motif; other site 324057003185 uracil transporter; Provisional; Region: PRK10720 324057003186 Cadherin repeat-like domain; Region: CA_like; cl15786 324057003187 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 324057003188 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057003189 S-layer homology domain; Region: SLH; pfam00395 324057003190 S-layer homology domain; Region: SLH; pfam00395 324057003191 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 324057003192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057003195 SEC-C motif; Region: SEC-C; pfam02810 324057003196 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 324057003197 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 324057003198 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 324057003199 Protein of unknown function (DUF458); Region: DUF458; cl00861 324057003200 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057003201 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 324057003202 active site 324057003203 metal binding site [ion binding]; metal-binding site 324057003204 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 324057003205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057003206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057003207 dimer interface [polypeptide binding]; other site 324057003208 phosphorylation site [posttranslational modification] 324057003209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003210 ATP binding site [chemical binding]; other site 324057003211 Mg2+ binding site [ion binding]; other site 324057003212 G-X-G motif; other site 324057003213 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 324057003214 hypothetical protein; Provisional; Region: PRK11479 324057003215 short chain dehydrogenase; Provisional; Region: PRK06701 324057003216 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 324057003217 NAD binding site [chemical binding]; other site 324057003218 metal binding site [ion binding]; metal-binding site 324057003219 active site 324057003220 Imelysin; Region: Peptidase_M75; cl09159 324057003221 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 324057003222 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 324057003223 Iron permease FTR1 family; Region: FTR1; cl00475 324057003224 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 324057003225 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 324057003226 nucleophilic elbow; other site 324057003227 catalytic triad; other site 324057003228 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 324057003229 active site flap/lid [active] 324057003230 nucleophilic elbow; other site 324057003231 catalytic triad [active] 324057003232 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 324057003233 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 324057003234 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 324057003235 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 324057003236 active site 324057003237 dimer interface [polypeptide binding]; other site 324057003238 motif 1; other site 324057003239 motif 2; other site 324057003240 motif 3; other site 324057003241 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 324057003242 anticodon binding site; other site 324057003243 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324057003244 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 324057003245 Heat induced stress protein YflT; Region: YflT; pfam11181 324057003246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003247 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324057003248 Cupin domain; Region: Cupin_2; cl09118 324057003249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003252 galactokinase; Provisional; Region: PRK05322 324057003253 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 324057003254 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057003255 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324057003256 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 324057003257 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324057003258 NAD binding site [chemical binding]; other site 324057003259 homodimer interface [polypeptide binding]; other site 324057003260 active site 324057003261 substrate binding site [chemical binding]; other site 324057003262 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 324057003263 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 324057003264 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 324057003265 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 324057003266 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 324057003267 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057003268 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057003270 S-adenosylmethionine binding site [chemical binding]; other site 324057003271 PAS domain; Region: PAS_9; pfam13426 324057003272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057003273 metal binding site [ion binding]; metal-binding site 324057003274 active site 324057003275 I-site; other site 324057003276 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057003277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057003278 Zn2+ binding site [ion binding]; other site 324057003279 Mg2+ binding site [ion binding]; other site 324057003280 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057003281 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057003282 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 324057003283 thiamine monophosphate kinase; Provisional; Region: PRK05731 324057003284 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 324057003285 ATP binding site [chemical binding]; other site 324057003286 dimerization interface [polypeptide binding]; other site 324057003287 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 324057003288 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 324057003289 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057003290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057003291 Coenzyme A binding pocket [chemical binding]; other site 324057003292 UGMP family protein; Validated; Region: PRK09604 324057003293 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 324057003294 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 324057003295 2-isopropylmalate synthase; Validated; Region: PRK00915 324057003296 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 324057003297 active site 324057003298 catalytic residues [active] 324057003299 metal binding site [ion binding]; metal-binding site 324057003300 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 324057003301 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057003302 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057003303 Walker A/P-loop; other site 324057003304 ATP binding site [chemical binding]; other site 324057003305 Q-loop/lid; other site 324057003306 ABC transporter signature motif; other site 324057003307 Walker B; other site 324057003308 D-loop; other site 324057003309 H-loop/switch region; other site 324057003310 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324057003311 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 324057003312 substrate binding pocket [chemical binding]; other site 324057003313 substrate-Mg2+ binding site; other site 324057003314 aspartate-rich region 1; other site 324057003315 aspartate-rich region 2; other site 324057003316 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 324057003317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003318 Histidine kinase; Region: HisKA_3; pfam07730 324057003319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003320 ATP binding site [chemical binding]; other site 324057003321 Mg2+ binding site [ion binding]; other site 324057003322 G-X-G motif; other site 324057003323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057003324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003325 active site 324057003326 phosphorylation site [posttranslational modification] 324057003327 intermolecular recognition site; other site 324057003328 dimerization interface [polypeptide binding]; other site 324057003329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057003330 DNA binding residues [nucleotide binding] 324057003331 dimerization interface [polypeptide binding]; other site 324057003332 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057003333 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003334 Walker A/P-loop; other site 324057003335 ATP binding site [chemical binding]; other site 324057003336 Q-loop/lid; other site 324057003337 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057003338 ABC transporter signature motif; other site 324057003339 Walker B; other site 324057003340 ABC transporter; Region: ABC_tran_2; pfam12848 324057003341 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057003342 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 324057003343 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 324057003344 trimer interface [polypeptide binding]; other site 324057003345 dimer interface [polypeptide binding]; other site 324057003346 putative active site [active] 324057003347 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 324057003348 MPT binding site; other site 324057003349 trimer interface [polypeptide binding]; other site 324057003350 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 324057003351 putative MPT binding site; other site 324057003352 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 324057003353 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 324057003354 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 324057003355 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324057003356 ligand binding site; other site 324057003357 oligomer interface; other site 324057003358 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324057003359 N-terminal domain interface [polypeptide binding]; other site 324057003360 sulfate 1 binding site; other site 324057003361 glycogen branching enzyme; Provisional; Region: PRK12313 324057003362 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 324057003363 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 324057003364 active site 324057003365 catalytic site [active] 324057003366 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 324057003367 glycogen synthase; Provisional; Region: glgA; PRK00654 324057003368 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 324057003369 ADP-binding pocket [chemical binding]; other site 324057003370 homodimer interface [polypeptide binding]; other site 324057003371 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324057003372 homodimer interface [polypeptide binding]; other site 324057003373 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324057003374 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 324057003375 active site 324057003376 homodimer interface [polypeptide binding]; other site 324057003377 catalytic site [active] 324057003378 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057003379 classical (c) SDRs; Region: SDR_c; cd05233 324057003380 NAD(P) binding site [chemical binding]; other site 324057003381 active site 324057003382 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057003383 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057003384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057003385 Helix-turn-helix domains; Region: HTH; cl00088 324057003386 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 324057003387 oligomerisation interface [polypeptide binding]; other site 324057003388 mobile loop; other site 324057003389 roof hairpin; other site 324057003390 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 324057003391 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 324057003392 ring oligomerisation interface [polypeptide binding]; other site 324057003393 ATP/Mg binding site [chemical binding]; other site 324057003394 stacking interactions; other site 324057003395 hinge regions; other site 324057003396 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057003397 DinB superfamily; Region: DinB_2; pfam12867 324057003398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057003399 active site 324057003400 xanthine permease; Region: pbuX; TIGR03173 324057003401 hypothetical protein; Provisional; Region: PRK11281 324057003402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057003403 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057003404 substrate binding pocket [chemical binding]; other site 324057003405 membrane-bound complex binding site; other site 324057003406 hinge residues; other site 324057003407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003408 dimer interface [polypeptide binding]; other site 324057003409 conserved gate region; other site 324057003410 putative PBP binding loops; other site 324057003411 ABC-ATPase subunit interface; other site 324057003412 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057003413 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 324057003414 Walker A/P-loop; other site 324057003415 ATP binding site [chemical binding]; other site 324057003416 Q-loop/lid; other site 324057003417 ABC transporter signature motif; other site 324057003418 Walker B; other site 324057003419 D-loop; other site 324057003420 H-loop/switch region; other site 324057003421 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057003422 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 324057003423 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 324057003424 dimer interface [polypeptide binding]; other site 324057003425 active site 324057003426 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324057003427 GAF domain; Region: GAF; cl15785 324057003428 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 324057003429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003430 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 324057003431 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057003432 Cache domain; Region: Cache_1; pfam02743 324057003433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057003434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057003435 metal binding site [ion binding]; metal-binding site 324057003436 active site 324057003437 I-site; other site 324057003438 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057003439 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057003440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003441 pyruvate kinase; Provisional; Region: PRK05826 324057003442 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 324057003443 domain interfaces; other site 324057003444 active site 324057003445 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 324057003446 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 324057003447 active site 324057003448 homodimer interface [polypeptide binding]; other site 324057003449 homotetramer interface [polypeptide binding]; other site 324057003450 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 324057003451 active site 324057003452 homodimer interface [polypeptide binding]; other site 324057003453 homotetramer interface [polypeptide binding]; other site 324057003454 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057003455 Interdomain contacts; other site 324057003456 S-layer homology domain; Region: SLH; pfam00395 324057003457 S-layer homology domain; Region: SLH; pfam00395 324057003458 S-layer homology domain; Region: SLH; pfam00395 324057003459 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 324057003460 alanine racemase; Reviewed; Region: alr; PRK00053 324057003461 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 324057003462 active site 324057003463 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057003464 dimer interface [polypeptide binding]; other site 324057003465 substrate binding site [chemical binding]; other site 324057003466 catalytic residues [active] 324057003467 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 324057003468 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cl00077 324057003469 PemK-like protein; Region: PemK; cl00995 324057003470 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 324057003471 AAA domain; Region: AAA_31; pfam13614 324057003472 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 324057003473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003474 Walker A motif; other site 324057003475 ATP binding site [chemical binding]; other site 324057003476 Walker B motif; other site 324057003477 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 324057003478 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324057003479 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324057003480 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 324057003481 active site 324057003482 Bacterial PH domain; Region: DUF304; cl01348 324057003483 Predicted membrane protein [Function unknown]; Region: COG3428 324057003484 Bacterial PH domain; Region: DUF304; cl01348 324057003485 Bacterial PH domain; Region: DUF304; cl01348 324057003486 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 324057003487 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 324057003488 Amidase; Region: Amidase; cl11426 324057003489 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 324057003490 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 324057003491 GatB domain; Region: GatB_Yqey; cl11497 324057003492 MgtC family; Region: MgtC; pfam02308 324057003493 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057003494 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057003495 ferric uptake regulator; Provisional; Region: fur; PRK09462 324057003496 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057003497 metal binding site 2 [ion binding]; metal-binding site 324057003498 putative DNA binding helix; other site 324057003499 metal binding site 1 [ion binding]; metal-binding site 324057003500 dimer interface [polypeptide binding]; other site 324057003501 structural Zn2+ binding site [ion binding]; other site 324057003502 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057003503 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057003504 active site 324057003505 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 324057003506 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057003507 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057003508 Spore germination protein; Region: Spore_permease; cl15802 324057003509 PspA/IM30 family; Region: PspA_IM30; pfam04012 324057003510 PspC domain; Region: PspC; cl00864 324057003511 PspA/IM30 family; Region: PspA_IM30; pfam04012 324057003512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057003513 Histidine kinase; Region: HisKA_3; pfam07730 324057003514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003515 ATP binding site [chemical binding]; other site 324057003516 Mg2+ binding site [ion binding]; other site 324057003517 G-X-G motif; other site 324057003518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057003519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003520 active site 324057003521 phosphorylation site [posttranslational modification] 324057003522 intermolecular recognition site; other site 324057003523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057003524 DNA binding residues [nucleotide binding] 324057003525 dimerization interface [polypeptide binding]; other site 324057003526 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 324057003527 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 324057003528 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 324057003529 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 324057003530 Putative cyclase; Region: Cyclase; cl00814 324057003531 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 324057003532 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 324057003533 G1 box; other site 324057003534 putative GEF interaction site [polypeptide binding]; other site 324057003535 GTP/Mg2+ binding site [chemical binding]; other site 324057003536 Switch I region; other site 324057003537 G2 box; other site 324057003538 G3 box; other site 324057003539 Switch II region; other site 324057003540 G4 box; other site 324057003541 G5 box; other site 324057003542 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 324057003543 TM2 domain; Region: TM2; cl00984 324057003544 TM2 domain; Region: TM2; cl00984 324057003545 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003547 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057003548 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057003549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003551 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 324057003552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057003553 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057003554 active site 324057003555 Small, acid-soluble spore protein I; Region: SSPI; cl07940 324057003556 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324057003557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003558 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 324057003559 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 324057003560 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 324057003561 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 324057003562 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057003563 active site 324057003564 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057003565 Ca binding site [ion binding]; other site 324057003566 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057003567 S-layer homology domain; Region: SLH; pfam00395 324057003568 S-layer homology domain; Region: SLH; pfam00395 324057003569 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 324057003570 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057003571 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057003572 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057003573 S-layer homology domain; Region: SLH; pfam00395 324057003574 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057003575 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 324057003576 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 324057003577 active site 324057003578 DNA binding site [nucleotide binding] 324057003579 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 324057003580 DNA binding site [nucleotide binding] 324057003581 phage shock protein A; Region: phageshock_pspA; TIGR02977 324057003582 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324057003583 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 324057003584 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057003585 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057003586 Copper resistance protein D; Region: CopD; cl00563 324057003587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057003588 dimerization interface [polypeptide binding]; other site 324057003589 putative DNA binding site [nucleotide binding]; other site 324057003590 putative Zn2+ binding site [ion binding]; other site 324057003591 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324057003592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057003594 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 324057003595 dimer interface [polypeptide binding]; other site 324057003596 catalytic triad [active] 324057003597 peroxidatic and resolving cysteines [active] 324057003598 Helix-turn-helix domains; Region: HTH; cl00088 324057003599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057003600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057003601 active site 324057003602 catalytic tetrad [active] 324057003603 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057003604 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057003605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057003607 sugar efflux transporter; Region: 2A0120; TIGR00899 324057003608 putative substrate translocation pore; other site 324057003609 Predicted kinase [General function prediction only]; Region: COG0645 324057003610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003611 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057003612 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057003613 S-layer homology domain; Region: SLH; pfam00395 324057003614 S-layer homology domain; Region: SLH; pfam00395 324057003615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057003616 Helix-turn-helix domains; Region: HTH; cl00088 324057003617 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 324057003618 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 324057003619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057003620 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057003621 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057003622 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057003623 active site 324057003624 catalytic tetrad [active] 324057003625 Cupin domain; Region: Cupin_2; cl09118 324057003626 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003628 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057003629 EamA-like transporter family; Region: EamA; cl01037 324057003630 EamA-like transporter family; Region: EamA; cl01037 324057003631 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057003632 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 324057003633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057003634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057003635 S-adenosylmethionine binding site [chemical binding]; other site 324057003636 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057003637 active site 324057003638 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 324057003639 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003641 active site 324057003642 phosphorylation site [posttranslational modification] 324057003643 intermolecular recognition site; other site 324057003644 dimerization interface [polypeptide binding]; other site 324057003645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003647 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057003648 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 324057003649 active site 324057003650 metal binding site [ion binding]; metal-binding site 324057003651 homodimer interface [polypeptide binding]; other site 324057003652 catalytic site [active] 324057003653 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057003654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057003656 Histidine kinase; Region: His_kinase; pfam06580 324057003657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003658 ATP binding site [chemical binding]; other site 324057003659 Mg2+ binding site [ion binding]; other site 324057003660 G-X-G motif; other site 324057003661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003664 dimerization interface [polypeptide binding]; other site 324057003665 Histidine kinase; Region: His_kinase; pfam06580 324057003666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003667 ATP binding site [chemical binding]; other site 324057003668 Mg2+ binding site [ion binding]; other site 324057003669 G-X-G motif; other site 324057003670 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057003671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003672 active site 324057003673 phosphorylation site [posttranslational modification] 324057003674 intermolecular recognition site; other site 324057003675 dimerization interface [polypeptide binding]; other site 324057003676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003677 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057003679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003681 dimer interface [polypeptide binding]; other site 324057003682 conserved gate region; other site 324057003683 putative PBP binding loops; other site 324057003684 ABC-ATPase subunit interface; other site 324057003685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003686 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003687 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003689 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057003690 Cupin domain; Region: Cupin_2; cl09118 324057003691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003693 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057003694 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057003695 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 324057003696 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 324057003697 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 324057003698 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621 324057003699 putative ligand binding site [chemical binding]; other site 324057003700 S-layer homology domain; Region: SLH; pfam00395 324057003701 S-layer homology domain; Region: SLH; pfam00395 324057003702 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057003703 MatE; Region: MatE; cl10513 324057003704 MatE; Region: MatE; cl10513 324057003705 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003707 dimer interface [polypeptide binding]; other site 324057003708 conserved gate region; other site 324057003709 ABC-ATPase subunit interface; other site 324057003710 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003712 dimer interface [polypeptide binding]; other site 324057003713 conserved gate region; other site 324057003714 ABC-ATPase subunit interface; other site 324057003715 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003716 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003717 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057003718 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 324057003719 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057003720 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621 324057003721 putative ligand binding site [chemical binding]; other site 324057003722 S-layer homology domain; Region: SLH; pfam00395 324057003723 S-layer homology domain; Region: SLH; pfam00395 324057003724 S-layer homology domain; Region: SLH; pfam00395 324057003725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057003728 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057003729 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057003730 PA14 domain; Region: PA14; cl08459 324057003731 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057003732 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057003733 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057003734 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 324057003735 metal binding site [ion binding]; metal-binding site 324057003736 substrate binding pocket [chemical binding]; other site 324057003737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057003738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003739 NAD(P) binding site [chemical binding]; other site 324057003740 active site 324057003741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057003742 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057003744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003745 Cupin domain; Region: Cupin_2; cl09118 324057003746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003749 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 324057003750 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 324057003751 tetramer interface [polypeptide binding]; other site 324057003752 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 324057003753 active site 324057003754 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 324057003755 active site 324057003756 dimer interface [polypeptide binding]; other site 324057003757 magnesium binding site [ion binding]; other site 324057003758 Helix-turn-helix domains; Region: HTH; cl00088 324057003759 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057003760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057003761 dimer interface [polypeptide binding]; other site 324057003762 putative CheW interface [polypeptide binding]; other site 324057003763 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057003764 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057003765 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 324057003766 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 324057003767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057003768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057003769 DNA binding site [nucleotide binding] 324057003770 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057003771 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 324057003772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057003773 Helix-turn-helix domains; Region: HTH; cl00088 324057003774 Predicted membrane protein [Function unknown]; Region: COG1511 324057003775 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057003776 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 324057003777 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057003778 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057003779 Sulfatase; Region: Sulfatase; cl10460 324057003780 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324057003781 nucleoside/Zn binding site; other site 324057003782 dimer interface [polypeptide binding]; other site 324057003783 catalytic motif [active] 324057003784 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 324057003785 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057003786 lipoyl synthase; Provisional; Region: PRK05481 324057003787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057003788 FeS/SAM binding site; other site 324057003789 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 324057003790 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 324057003791 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 324057003792 Nucleoside recognition; Region: Gate; cl00486 324057003793 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 324057003794 apolar tunnel; other site 324057003795 heme binding site [chemical binding]; other site 324057003796 dimerization interface [polypeptide binding]; other site 324057003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 324057003798 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 324057003799 YycC-like protein; Region: YycC; pfam14174 324057003800 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 324057003801 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 324057003802 active site 324057003803 Zn binding site [ion binding]; other site 324057003804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324057003805 FOG: CBS domain [General function prediction only]; Region: COG0517 324057003806 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 324057003807 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 324057003808 putative active site [active] 324057003809 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324057003810 active site 324057003811 multimer interface [polypeptide binding]; other site 324057003812 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 324057003813 active site 324057003814 intersubunit interactions; other site 324057003815 catalytic residue [active] 324057003816 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057003817 Chain length determinant protein; Region: Wzz; cl15801 324057003818 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057003819 active site 324057003820 tetramer interface; other site 324057003821 Bacterial sugar transferase; Region: Bac_transf; cl00939 324057003822 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 324057003823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057003824 active site 324057003825 Cupin domain; Region: Cupin_2; cl09118 324057003826 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057003827 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057003828 Chain length determinant protein; Region: Wzz; cl15801 324057003829 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057003830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003831 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057003832 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 324057003833 DXD motif; other site 324057003834 O-Antigen ligase; Region: Wzy_C; cl04850 324057003835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057003836 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057003837 MatE; Region: MatE; cl10513 324057003838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057003839 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057003840 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057003841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057003842 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 324057003843 putative ADP-binding pocket [chemical binding]; other site 324057003844 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 324057003845 active site 324057003846 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 324057003847 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057003848 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057003849 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 324057003850 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003851 Walker A/P-loop; other site 324057003852 ATP binding site [chemical binding]; other site 324057003853 Q-loop/lid; other site 324057003854 ABC transporter signature motif; other site 324057003855 Walker B; other site 324057003856 D-loop; other site 324057003857 H-loop/switch region; other site 324057003858 AAA domain; Region: AAA_31; pfam13614 324057003859 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324057003860 P-loop; other site 324057003861 Magnesium ion binding site [ion binding]; other site 324057003862 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 324057003863 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 324057003864 ATP binding site [chemical binding]; other site 324057003865 Walker A motif; other site 324057003866 hexamer interface [polypeptide binding]; other site 324057003867 Walker B motif; other site 324057003868 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 324057003869 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 324057003870 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 324057003871 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 324057003872 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324057003873 phosphopeptide binding site; other site 324057003874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003875 TIGR01777 family protein; Region: yfcH 324057003876 NAD(P) binding site [chemical binding]; other site 324057003877 active site 324057003878 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 324057003879 endonuclease IV; Provisional; Region: PRK01060 324057003880 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 324057003881 AP (apurinic/apyrimidinic) site pocket; other site 324057003882 DNA interaction; other site 324057003883 Metal-binding active site; metal-binding site 324057003884 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 324057003885 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 324057003886 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 324057003887 putative active site [active] 324057003888 putative substrate binding site [chemical binding]; other site 324057003889 putative cosubstrate binding site; other site 324057003890 catalytic site [active] 324057003891 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 324057003892 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 324057003893 TPP-binding site [chemical binding]; other site 324057003894 dimer interface [polypeptide binding]; other site 324057003895 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324057003896 PYR/PP interface [polypeptide binding]; other site 324057003897 dimer interface [polypeptide binding]; other site 324057003898 TPP binding site [chemical binding]; other site 324057003899 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 324057003900 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 324057003901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003902 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 324057003903 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 324057003904 active site 324057003905 dimer interface [polypeptide binding]; other site 324057003906 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 324057003907 dimer interface [polypeptide binding]; other site 324057003908 active site 324057003909 Uncharacterized conserved protein [Function unknown]; Region: COG1739 324057003910 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 324057003911 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 324057003912 sulfate transport protein; Provisional; Region: cysT; CHL00187 324057003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003914 dimer interface [polypeptide binding]; other site 324057003915 conserved gate region; other site 324057003916 putative PBP binding loops; other site 324057003917 ABC-ATPase subunit interface; other site 324057003918 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003920 dimer interface [polypeptide binding]; other site 324057003921 conserved gate region; other site 324057003922 putative PBP binding loops; other site 324057003923 ABC-ATPase subunit interface; other site 324057003924 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 324057003925 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057003926 Walker A/P-loop; other site 324057003927 ATP binding site [chemical binding]; other site 324057003928 Q-loop/lid; other site 324057003929 ABC transporter signature motif; other site 324057003930 Walker B; other site 324057003931 D-loop; other site 324057003932 H-loop/switch region; other site 324057003933 TOBE domain; Region: TOBE_2; cl01440 324057003934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057003935 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057003937 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057003938 active site 324057003939 motif I; other site 324057003940 motif II; other site 324057003941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057003942 motif II; other site 324057003943 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057003944 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 324057003945 C-terminal peptidase (prc); Region: prc; TIGR00225 324057003946 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324057003947 protein binding site [polypeptide binding]; other site 324057003948 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324057003949 Catalytic dyad [active] 324057003950 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 324057003951 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 324057003952 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 324057003953 Ferritin-like domain; Region: Ferritin; pfam00210 324057003954 ferroxidase diiron center [ion binding]; other site 324057003955 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324057003956 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057003957 Family description; Region: UvrD_C_2; cl15862 324057003958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057003959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057003960 Coenzyme A binding pocket [chemical binding]; other site 324057003961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057003962 Coenzyme A binding pocket [chemical binding]; other site 324057003963 ferric uptake regulator; Provisional; Region: fur; PRK09462 324057003964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057003965 metal binding site 2 [ion binding]; metal-binding site 324057003966 putative DNA binding helix; other site 324057003967 metal binding site 1 [ion binding]; metal-binding site 324057003968 dimer interface [polypeptide binding]; other site 324057003969 structural Zn2+ binding site [ion binding]; other site 324057003970 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 324057003971 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 324057003972 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 324057003973 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 324057003974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057003975 RNA binding surface [nucleotide binding]; other site 324057003976 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057003977 active site 324057003978 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057003979 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 324057003980 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 324057003981 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 324057003982 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 324057003983 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 324057003984 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 324057003985 Substrate-binding site [chemical binding]; other site 324057003986 Substrate specificity [chemical binding]; other site 324057003987 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 324057003988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057003989 putative substrate translocation pore; other site 324057003990 Helix-turn-helix domains; Region: HTH; cl00088 324057003991 putative DNA binding site [nucleotide binding]; other site 324057003992 putative Zn2+ binding site [ion binding]; other site 324057003993 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057003994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057003995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057003996 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 324057003997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057003999 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 324057004000 active site 324057004001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004002 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 324057004003 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 324057004004 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 324057004005 DXD motif; other site 324057004006 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 324057004007 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 324057004008 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 324057004009 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 324057004010 ribosomal protein L20; Region: rpl20; CHL00068 324057004011 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 324057004012 23S rRNA binding site [nucleotide binding]; other site 324057004013 L21 binding site [polypeptide binding]; other site 324057004014 L13 binding site [polypeptide binding]; other site 324057004015 Cupin domain; Region: Cupin_2; cl09118 324057004016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004019 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 324057004020 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057004021 Ca binding site [ion binding]; other site 324057004022 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057004023 Ca binding site [ion binding]; other site 324057004024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004026 dimerization interface [polypeptide binding]; other site 324057004027 Histidine kinase; Region: His_kinase; pfam06580 324057004028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004029 ATP binding site [chemical binding]; other site 324057004030 Mg2+ binding site [ion binding]; other site 324057004031 G-X-G motif; other site 324057004032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004033 active site 324057004034 phosphorylation site [posttranslational modification] 324057004035 intermolecular recognition site; other site 324057004036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004039 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004041 dimer interface [polypeptide binding]; other site 324057004042 conserved gate region; other site 324057004043 ABC-ATPase subunit interface; other site 324057004044 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004046 dimer interface [polypeptide binding]; other site 324057004047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057004048 ABC-ATPase subunit interface; other site 324057004049 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057004051 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057004052 Predicted acetyltransferase [General function prediction only]; Region: COG3153 324057004053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057004054 Coenzyme A binding pocket [chemical binding]; other site 324057004055 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 324057004056 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057004057 PYR/PP interface [polypeptide binding]; other site 324057004058 dimer interface [polypeptide binding]; other site 324057004059 TPP binding site [chemical binding]; other site 324057004060 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 324057004061 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324057004062 TPP-binding site [chemical binding]; other site 324057004063 dimer interface [polypeptide binding]; other site 324057004064 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 324057004065 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 324057004066 putative valine binding site [chemical binding]; other site 324057004067 dimer interface [polypeptide binding]; other site 324057004068 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 324057004069 ketol-acid reductoisomerase; Provisional; Region: PRK05479 324057004070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004071 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 324057004072 2-isopropylmalate synthase; Validated; Region: PRK00915 324057004073 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 324057004074 active site 324057004075 catalytic residues [active] 324057004076 metal binding site [ion binding]; metal-binding site 324057004077 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 324057004078 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 324057004079 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 324057004080 tartrate dehydrogenase; Provisional; Region: PRK08194 324057004081 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 324057004082 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 324057004083 dimer interface [polypeptide binding]; other site 324057004084 decamer (pentamer of dimers) interface [polypeptide binding]; other site 324057004085 catalytic triad [active] 324057004086 peroxidatic and resolving cysteines [active] 324057004087 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057004088 Spore germination protein; Region: Spore_permease; cl15802 324057004089 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057004090 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 324057004091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057004092 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 324057004093 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 324057004094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057004095 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057004096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004097 dimer interface [polypeptide binding]; other site 324057004098 phosphorylation site [posttranslational modification] 324057004099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004100 ATP binding site [chemical binding]; other site 324057004101 Mg2+ binding site [ion binding]; other site 324057004102 G-X-G motif; other site 324057004103 multifunctional aminopeptidase A; Provisional; Region: PRK00913 324057004104 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 324057004105 interface (dimer of trimers) [polypeptide binding]; other site 324057004106 Substrate-binding/catalytic site; other site 324057004107 Zn-binding sites [ion binding]; other site 324057004108 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057004109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004110 active site 324057004111 phosphorylation site [posttranslational modification] 324057004112 intermolecular recognition site; other site 324057004113 dimerization interface [polypeptide binding]; other site 324057004114 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057004115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057004116 Histidine kinase; Region: His_kinase; pfam06580 324057004117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004118 ATP binding site [chemical binding]; other site 324057004119 Mg2+ binding site [ion binding]; other site 324057004120 G-X-G motif; other site 324057004121 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004122 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004124 dimer interface [polypeptide binding]; other site 324057004125 conserved gate region; other site 324057004126 putative PBP binding loops; other site 324057004127 ABC-ATPase subunit interface; other site 324057004128 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004130 dimer interface [polypeptide binding]; other site 324057004131 conserved gate region; other site 324057004132 ABC-ATPase subunit interface; other site 324057004133 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 324057004134 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 324057004135 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 324057004136 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 324057004137 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057004138 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057004139 inhibitor binding site; inhibition site 324057004140 active site 324057004141 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 324057004142 putative active site [active] 324057004143 putative FMN binding site [chemical binding]; other site 324057004144 putative substrate binding site [chemical binding]; other site 324057004145 putative catalytic residue [active] 324057004146 A new structural DNA glycosylase; Region: AlkD_like; cd06561 324057004147 active site 324057004148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004149 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057004150 putative substrate translocation pore; other site 324057004151 Cupin domain; Region: Cupin_2; cl09118 324057004152 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004154 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 324057004155 intracellular protease, PfpI family; Region: PfpI; TIGR01382 324057004156 conserved cys residue [active] 324057004157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057004159 Histidine kinase; Region: His_kinase; pfam06580 324057004160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004161 ATP binding site [chemical binding]; other site 324057004162 Mg2+ binding site [ion binding]; other site 324057004163 G-X-G motif; other site 324057004164 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057004165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004166 active site 324057004167 phosphorylation site [posttranslational modification] 324057004168 intermolecular recognition site; other site 324057004169 dimerization interface [polypeptide binding]; other site 324057004170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004172 dimer interface [polypeptide binding]; other site 324057004173 conserved gate region; other site 324057004174 putative PBP binding loops; other site 324057004175 ABC-ATPase subunit interface; other site 324057004176 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004178 dimer interface [polypeptide binding]; other site 324057004179 conserved gate region; other site 324057004180 putative PBP binding loops; other site 324057004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057004182 ABC-ATPase subunit interface; other site 324057004183 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057004185 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 324057004186 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324057004187 substrate binding [chemical binding]; other site 324057004188 active site 324057004189 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324057004190 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057004191 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 324057004192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004193 putative substrate translocation pore; other site 324057004194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004195 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057004196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004197 active site 324057004198 phosphorylation site [posttranslational modification] 324057004199 intermolecular recognition site; other site 324057004200 dimerization interface [polypeptide binding]; other site 324057004201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004206 dimerization interface [polypeptide binding]; other site 324057004207 Histidine kinase; Region: His_kinase; pfam06580 324057004208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004209 ATP binding site [chemical binding]; other site 324057004210 Mg2+ binding site [ion binding]; other site 324057004211 G-X-G motif; other site 324057004212 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057004213 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057004214 ligand binding site [chemical binding]; other site 324057004215 PAS domain S-box; Region: sensory_box; TIGR00229 324057004216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004217 putative active site [active] 324057004218 heme pocket [chemical binding]; other site 324057004219 PAS domain S-box; Region: sensory_box; TIGR00229 324057004220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057004221 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057004222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004223 putative active site [active] 324057004224 heme pocket [chemical binding]; other site 324057004225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004226 dimer interface [polypeptide binding]; other site 324057004227 phosphorylation site [posttranslational modification] 324057004228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004229 ATP binding site [chemical binding]; other site 324057004230 Mg2+ binding site [ion binding]; other site 324057004231 G-X-G motif; other site 324057004232 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057004233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057004234 DNA binding site [nucleotide binding] 324057004235 domain linker motif; other site 324057004236 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057004237 ligand binding site [chemical binding]; other site 324057004238 dimerization interface [polypeptide binding]; other site 324057004239 L-fucose isomerase; Provisional; Region: fucI; PRK10991 324057004240 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 324057004241 hexamer (dimer of trimers) interface [polypeptide binding]; other site 324057004242 trimer interface [polypeptide binding]; other site 324057004243 substrate binding site [chemical binding]; other site 324057004244 Mn binding site [ion binding]; other site 324057004245 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057004246 intersubunit interface [polypeptide binding]; other site 324057004247 active site 324057004248 Zn2+ binding site [ion binding]; other site 324057004249 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 324057004250 N- and C-terminal domain interface [polypeptide binding]; other site 324057004251 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 324057004252 active site 324057004253 catalytic site [active] 324057004254 metal binding site [ion binding]; metal-binding site 324057004255 ATP binding site [chemical binding]; other site 324057004256 carbohydrate binding site [chemical binding]; other site 324057004257 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 324057004258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057004259 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 324057004260 Mor transcription activator family; Region: Mor; cl02360 324057004261 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057004262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057004263 DNA-binding site [nucleotide binding]; DNA binding site 324057004264 FCD domain; Region: FCD; cl11656 324057004265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057004267 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057004268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004269 dimer interface [polypeptide binding]; other site 324057004270 conserved gate region; other site 324057004271 putative PBP binding loops; other site 324057004272 ABC-ATPase subunit interface; other site 324057004273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004275 dimer interface [polypeptide binding]; other site 324057004276 conserved gate region; other site 324057004277 putative PBP binding loops; other site 324057004278 ABC-ATPase subunit interface; other site 324057004279 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 324057004280 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057004281 homodimer interface [polypeptide binding]; other site 324057004282 substrate-cofactor binding pocket; other site 324057004283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004284 catalytic residue [active] 324057004285 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 324057004286 active site 324057004287 acetylornithine aminotransferase; Provisional; Region: PRK02627 324057004288 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057004289 inhibitor-cofactor binding pocket; inhibition site 324057004290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004291 catalytic residue [active] 324057004292 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324057004293 Cation transport protein; Region: TrkH; cl10514 324057004294 Protein of unknown function (DUF445); Region: DUF445; pfam04286 324057004295 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057004296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057004297 Walker A/P-loop; other site 324057004298 ATP binding site [chemical binding]; other site 324057004299 Q-loop/lid; other site 324057004300 ABC transporter signature motif; other site 324057004301 Walker B; other site 324057004302 D-loop; other site 324057004303 H-loop/switch region; other site 324057004304 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 324057004305 Helix-turn-helix domains; Region: HTH; cl00088 324057004306 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324057004307 dimerization interface [polypeptide binding]; other site 324057004308 active site 324057004309 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 324057004310 active site 324057004311 catalytic residues [active] 324057004312 metal binding site [ion binding]; metal-binding site 324057004313 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057004314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057004315 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057004316 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057004317 metal ion-dependent adhesion site (MIDAS); other site 324057004318 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057004319 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057004320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057004321 motif II; other site 324057004322 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 324057004323 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 324057004324 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 324057004325 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 324057004326 putative active site [active] 324057004327 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 324057004328 putative active site pocket [active] 324057004329 dimerization interface [polypeptide binding]; other site 324057004330 putative catalytic residue [active] 324057004331 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 324057004332 CHASE3 domain; Region: CHASE3; cl05000 324057004333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004334 dimerization interface [polypeptide binding]; other site 324057004335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057004336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057004337 dimer interface [polypeptide binding]; other site 324057004338 putative CheW interface [polypeptide binding]; other site 324057004339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004340 putative substrate translocation pore; other site 324057004341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057004342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057004343 Helix-turn-helix domains; Region: HTH; cl00088 324057004344 Histidine kinase; Region: HisKA_3; pfam07730 324057004345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004346 ATP binding site [chemical binding]; other site 324057004347 Mg2+ binding site [ion binding]; other site 324057004348 G-X-G motif; other site 324057004349 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057004350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004351 active site 324057004352 phosphorylation site [posttranslational modification] 324057004353 intermolecular recognition site; other site 324057004354 dimerization interface [polypeptide binding]; other site 324057004355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057004356 DNA binding residues [nucleotide binding] 324057004357 dimerization interface [polypeptide binding]; other site 324057004358 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 324057004359 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 324057004360 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 324057004361 dimer interface [polypeptide binding]; other site 324057004362 motif 1; other site 324057004363 active site 324057004364 motif 2; other site 324057004365 motif 3; other site 324057004366 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 324057004367 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 324057004368 putative tRNA-binding site [nucleotide binding]; other site 324057004369 B3/4 domain; Region: B3_4; cl11458 324057004370 tRNA synthetase B5 domain; Region: B5; cl08394 324057004371 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 324057004372 dimer interface [polypeptide binding]; other site 324057004373 motif 1; other site 324057004374 motif 3; other site 324057004375 motif 2; other site 324057004376 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 324057004377 Cell division protein ZapA; Region: ZapA; cl01146 324057004378 cell division protein MukB; Provisional; Region: mukB; PRK04863 324057004379 short chain dehydrogenase; Provisional; Region: PRK08703 324057004380 classical (c) SDRs; Region: SDR_c; cd05233 324057004381 NAD(P) binding site [chemical binding]; other site 324057004382 active site 324057004383 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057004384 Membrane protein of unknown function; Region: DUF360; cl00850 324057004385 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057004386 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 324057004387 Walker A/P-loop; other site 324057004388 ATP binding site [chemical binding]; other site 324057004389 Q-loop/lid; other site 324057004390 ABC transporter signature motif; other site 324057004391 Walker B; other site 324057004392 D-loop; other site 324057004393 H-loop/switch region; other site 324057004394 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 324057004395 Smr domain; Region: Smr; cl02619 324057004396 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057004397 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057004400 putative substrate translocation pore; other site 324057004401 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057004402 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057004403 dimer interface [polypeptide binding]; other site 324057004404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004405 catalytic residue [active] 324057004406 CotH protein; Region: CotH; pfam08757 324057004407 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 324057004408 Spore germination protein; Region: Spore_permease; cl15802 324057004409 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057004410 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057004411 Coat F domain; Region: Coat_F; cl15836 324057004412 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057004413 AsnC family; Region: AsnC_trans_reg; pfam01037 324057004414 hypothetical protein; Validated; Region: PRK07682 324057004415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057004416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004417 homodimer interface [polypeptide binding]; other site 324057004418 catalytic residue [active] 324057004419 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 324057004420 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057004421 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057004422 active site 324057004423 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 324057004424 ArsC family; Region: ArsC; pfam03960 324057004425 putative ArsC-like catalytic residues; other site 324057004426 putative TRX-like catalytic residues [active] 324057004427 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 324057004428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057004429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004430 homodimer interface [polypeptide binding]; other site 324057004431 catalytic residue [active] 324057004432 5'-3' exonuclease; Region: 53EXOc; smart00475 324057004433 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 324057004434 active site 324057004435 metal binding site 1 [ion binding]; metal-binding site 324057004436 putative 5' ssDNA interaction site; other site 324057004437 metal binding site 3; metal-binding site 324057004438 metal binding site 2 [ion binding]; metal-binding site 324057004439 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 324057004440 putative DNA binding site [nucleotide binding]; other site 324057004441 putative metal binding site [ion binding]; other site 324057004442 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 324057004443 S-layer homology domain; Region: SLH; pfam00395 324057004444 S-layer homology domain; Region: SLH; pfam00395 324057004445 S-layer homology domain; Region: SLH; pfam00395 324057004446 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057004447 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 324057004448 Phage Tail Collar Domain; Region: Collar; pfam07484 324057004449 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 324057004450 Phage Tail Collar Domain; Region: Collar; pfam07484 324057004451 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 324057004452 Phage Tail Collar Domain; Region: Collar; pfam07484 324057004453 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 324057004454 HRDC domain; Region: HRDC; cl02578 324057004455 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 324057004456 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 324057004457 Chemotaxis phosphatase CheX; Region: CheX; cl15816 324057004458 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 324057004459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004460 NAD(P) binding site [chemical binding]; other site 324057004461 active site 324057004462 helicase 45; Provisional; Region: PTZ00424 324057004463 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057004464 ATP binding site [chemical binding]; other site 324057004465 Mg++ binding site [ion binding]; other site 324057004466 motif III; other site 324057004467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057004468 nucleotide binding region [chemical binding]; other site 324057004469 ATP-binding site [chemical binding]; other site 324057004470 S-layer homology domain; Region: SLH; pfam00395 324057004471 S-layer homology domain; Region: SLH; pfam00395 324057004472 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057004473 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057004474 Walker A/P-loop; other site 324057004475 ATP binding site [chemical binding]; other site 324057004476 Q-loop/lid; other site 324057004477 ABC transporter signature motif; other site 324057004478 Walker B; other site 324057004479 D-loop; other site 324057004480 H-loop/switch region; other site 324057004481 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 324057004482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057004483 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 324057004484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004485 homodimer interface [polypeptide binding]; other site 324057004486 catalytic residue [active] 324057004487 Cupin domain; Region: Cupin_2; cl09118 324057004488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004490 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 324057004491 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057004492 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 324057004493 secreted effector protein PipB2; Provisional; Region: PRK15196 324057004494 secreted effector protein PipB2; Provisional; Region: PRK15196 324057004495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057004496 active site 324057004497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057004498 active site 324057004499 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057004500 Probable Catalytic site; other site 324057004501 metal-binding site 324057004502 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 324057004503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057004504 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 324057004505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057004506 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 324057004507 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 324057004508 dimer interface [polypeptide binding]; other site 324057004509 active site 324057004510 CoA binding pocket [chemical binding]; other site 324057004511 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057004512 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057004513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057004514 DNA binding residues [nucleotide binding] 324057004515 dimerization interface [polypeptide binding]; other site 324057004516 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057004517 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 324057004518 tetramer interface [polypeptide binding]; other site 324057004519 heme binding pocket [chemical binding]; other site 324057004520 Response regulator receiver domain; Region: Response_reg; pfam00072 324057004521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004522 active site 324057004523 phosphorylation site [posttranslational modification] 324057004524 intermolecular recognition site; other site 324057004525 dimerization interface [polypeptide binding]; other site 324057004526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004527 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004530 dimerization interface [polypeptide binding]; other site 324057004531 Histidine kinase; Region: His_kinase; pfam06580 324057004532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004533 ATP binding site [chemical binding]; other site 324057004534 Mg2+ binding site [ion binding]; other site 324057004535 G-X-G motif; other site 324057004536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057004538 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004540 dimer interface [polypeptide binding]; other site 324057004541 conserved gate region; other site 324057004542 putative PBP binding loops; other site 324057004543 ABC-ATPase subunit interface; other site 324057004544 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004546 dimer interface [polypeptide binding]; other site 324057004547 conserved gate region; other site 324057004548 putative PBP binding loops; other site 324057004549 ABC-ATPase subunit interface; other site 324057004550 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057004551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057004552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057004553 TPR motif; other site 324057004554 TPR repeat; Region: TPR_11; pfam13414 324057004555 binding surface 324057004556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057004557 binding surface 324057004558 TPR motif; other site 324057004559 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 324057004560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004561 ATP binding site [chemical binding]; other site 324057004562 Mg2+ binding site [ion binding]; other site 324057004563 G-X-G motif; other site 324057004564 SWIM zinc finger; Region: SWIM; cl15408 324057004565 SNF2 Helicase protein; Region: DUF3670; pfam12419 324057004566 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057004567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057004568 ATP binding site [chemical binding]; other site 324057004569 putative Mg++ binding site [ion binding]; other site 324057004570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057004571 nucleotide binding region [chemical binding]; other site 324057004572 ATP-binding site [chemical binding]; other site 324057004573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057004574 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057004575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004576 dimer interface [polypeptide binding]; other site 324057004577 conserved gate region; other site 324057004578 putative PBP binding loops; other site 324057004579 ABC-ATPase subunit interface; other site 324057004580 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004582 dimer interface [polypeptide binding]; other site 324057004583 conserved gate region; other site 324057004584 putative PBP binding loops; other site 324057004585 ABC-ATPase subunit interface; other site 324057004586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004587 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057004588 Histidine kinase; Region: His_kinase; pfam06580 324057004589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004590 ATP binding site [chemical binding]; other site 324057004591 Mg2+ binding site [ion binding]; other site 324057004592 G-X-G motif; other site 324057004593 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057004594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004595 active site 324057004596 phosphorylation site [posttranslational modification] 324057004597 intermolecular recognition site; other site 324057004598 dimerization interface [polypeptide binding]; other site 324057004599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004601 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057004602 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057004603 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057004604 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 324057004605 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057004606 inhibitor-cofactor binding pocket; inhibition site 324057004607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004608 catalytic residue [active] 324057004609 AAA domain; Region: AAA_26; pfam13500 324057004610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057004611 biotin synthase; Validated; Region: PRK06256 324057004612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057004613 FeS/SAM binding site; other site 324057004614 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 324057004615 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 324057004616 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 324057004617 substrate-cofactor binding pocket; other site 324057004618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004619 catalytic residue [active] 324057004620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057004621 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057004622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057004623 S-adenosylmethionine binding site [chemical binding]; other site 324057004624 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 324057004625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057004626 motif II; other site 324057004627 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057004628 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057004629 DNA binding residues [nucleotide binding] 324057004630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004631 short chain dehydrogenase; Provisional; Region: PRK06197 324057004632 NAD(P) binding site [chemical binding]; other site 324057004633 active site 324057004634 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057004635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004636 NAD(P) binding site [chemical binding]; other site 324057004637 active site 324057004638 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 324057004639 haloalkane dehalogenase; Provisional; Region: PRK03204 324057004640 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057004641 Helix-turn-helix domains; Region: HTH; cl00088 324057004642 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057004643 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 324057004644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057004645 Helix-turn-helix domains; Region: HTH; cl00088 324057004646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057004647 dimerization interface [polypeptide binding]; other site 324057004648 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057004649 metal ion-dependent adhesion site (MIDAS); other site 324057004650 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 324057004651 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057004652 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057004653 active site 324057004654 catalytic tetrad [active] 324057004655 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057004656 nudix motif; other site 324057004657 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057004658 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057004659 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004661 dimer interface [polypeptide binding]; other site 324057004662 conserved gate region; other site 324057004663 ABC-ATPase subunit interface; other site 324057004664 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004666 dimer interface [polypeptide binding]; other site 324057004667 conserved gate region; other site 324057004668 putative PBP binding loops; other site 324057004669 ABC-ATPase subunit interface; other site 324057004670 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004674 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057004675 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057004676 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 324057004677 putative ligand binding site [chemical binding]; other site 324057004678 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057004679 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057004680 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 324057004681 Glyco_18 domain; Region: Glyco_18; smart00636 324057004682 active site 324057004683 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057004684 DinB superfamily; Region: DinB_2; pfam12867 324057004685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057004686 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 324057004687 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 324057004688 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 324057004689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057004690 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057004691 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057004692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004693 putative active site [active] 324057004694 heme pocket [chemical binding]; other site 324057004695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004696 dimer interface [polypeptide binding]; other site 324057004697 phosphorylation site [posttranslational modification] 324057004698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004699 ATP binding site [chemical binding]; other site 324057004700 Mg2+ binding site [ion binding]; other site 324057004701 G-X-G motif; other site 324057004702 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 324057004703 Membrane transport protein; Region: Mem_trans; cl09117 324057004704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004705 dimerization interface [polypeptide binding]; other site 324057004706 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057004707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004708 putative active site [active] 324057004709 heme pocket [chemical binding]; other site 324057004710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004711 dimer interface [polypeptide binding]; other site 324057004712 phosphorylation site [posttranslational modification] 324057004713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004714 ATP binding site [chemical binding]; other site 324057004715 Mg2+ binding site [ion binding]; other site 324057004716 G-X-G motif; other site 324057004717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057004718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004719 active site 324057004720 phosphorylation site [posttranslational modification] 324057004721 intermolecular recognition site; other site 324057004722 dimerization interface [polypeptide binding]; other site 324057004723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057004724 DNA binding site [nucleotide binding] 324057004725 Cupin domain; Region: Cupin_2; cl09118 324057004726 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004728 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 324057004729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004730 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 324057004731 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 324057004732 GIY-YIG motif/motif A; other site 324057004733 active site 324057004734 catalytic site [active] 324057004735 putative DNA binding site [nucleotide binding]; other site 324057004736 metal binding site [ion binding]; metal-binding site 324057004737 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 324057004738 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 324057004739 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057004740 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 324057004741 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 324057004742 active site 324057004743 Zn binding site [ion binding]; other site 324057004744 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057004745 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 324057004746 metal binding site [ion binding]; metal-binding site 324057004747 Cupin domain; Region: Cupin_2; cl09118 324057004748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004751 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057004752 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057004753 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057004754 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 324057004755 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 324057004756 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 324057004757 active site 324057004758 HIGH motif; other site 324057004759 dimer interface [polypeptide binding]; other site 324057004760 KMSKS motif; other site 324057004761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057004762 RNA binding surface [nucleotide binding]; other site 324057004763 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057004764 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 324057004765 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324057004766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057004767 dimer interface [polypeptide binding]; other site 324057004768 putative CheW interface [polypeptide binding]; other site 324057004769 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 324057004770 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 324057004771 Walker A/P-loop; other site 324057004772 ATP binding site [chemical binding]; other site 324057004773 Q-loop/lid; other site 324057004774 ABC transporter signature motif; other site 324057004775 Walker B; other site 324057004776 D-loop; other site 324057004777 H-loop/switch region; other site 324057004778 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 324057004779 PhoU domain; Region: PhoU; pfam01895 324057004780 PhoU domain; Region: PhoU; pfam01895 324057004781 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057004782 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057004783 S-layer homology domain; Region: SLH; pfam00395 324057004784 S-layer homology domain; Region: SLH; pfam00395 324057004785 S-layer homology domain; Region: SLH; pfam00395 324057004786 DNA polymerase I; Provisional; Region: PRK05755 324057004787 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 324057004788 active site 324057004789 metal binding site 1 [ion binding]; metal-binding site 324057004790 putative 5' ssDNA interaction site; other site 324057004791 metal binding site 3; metal-binding site 324057004792 metal binding site 2 [ion binding]; metal-binding site 324057004793 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 324057004794 putative DNA binding site [nucleotide binding]; other site 324057004795 putative metal binding site [ion binding]; other site 324057004796 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 324057004797 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 324057004798 active site 324057004799 DNA binding site [nucleotide binding] 324057004800 catalytic site [active] 324057004801 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 324057004802 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 324057004803 DNA binding site [nucleotide binding] 324057004804 catalytic residue [active] 324057004805 H2TH interface [polypeptide binding]; other site 324057004806 putative catalytic residues [active] 324057004807 turnover-facilitating residue; other site 324057004808 intercalation triad [nucleotide binding]; other site 324057004809 8OG recognition residue [nucleotide binding]; other site 324057004810 putative reading head residues; other site 324057004811 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 324057004812 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324057004813 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 324057004814 Domain of unknown function DUF; Region: DUF204; pfam02659 324057004815 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 324057004816 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 324057004817 CoA-binding site [chemical binding]; other site 324057004818 ATP-binding [chemical binding]; other site 324057004819 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 324057004820 N-acetyl-D-glucosamine binding site [chemical binding]; other site 324057004821 catalytic residue [active] 324057004822 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057004823 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 324057004824 ATP cone domain; Region: ATP-cone; pfam03477 324057004825 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 324057004826 dimer interface [polypeptide binding]; other site 324057004827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057004828 metal binding site [ion binding]; metal-binding site 324057004829 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 324057004830 active site 324057004831 catalytic triad [active] 324057004832 oxyanion hole [active] 324057004833 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 324057004834 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 324057004835 Phage Terminase; Region: Terminase_1; pfam03354 324057004836 Phage portal protein; Region: Phage_portal; pfam04860 324057004837 Phage-related protein [Function unknown]; Region: COG4695; cl01923 324057004838 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 324057004839 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 324057004840 Phage capsid family; Region: Phage_capsid; pfam05065 324057004841 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 324057004842 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 324057004843 Phage major tail protein 2; Region: Phage_tail_2; cl11463 324057004844 Phage-related protein [Function unknown]; Region: COG5412 324057004845 VirE N-terminal domain; Region: VirE_N; pfam08800 324057004846 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 324057004847 Holin family; Region: Phage_holin_4; cl01989 324057004848 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 324057004849 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057004850 active site 324057004851 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057004852 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 324057004853 AAA-like domain; Region: AAA_10; pfam12846 324057004854 Accessory gene regulator B; Region: AgrB; cl01873 324057004855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057004856 non-specific DNA binding site [nucleotide binding]; other site 324057004857 salt bridge; other site 324057004858 sequence-specific DNA binding site [nucleotide binding]; other site 324057004859 Predicted transcriptional regulator [Transcription]; Region: COG2932 324057004860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057004861 non-specific DNA binding site [nucleotide binding]; other site 324057004862 salt bridge; other site 324057004863 sequence-specific DNA binding site [nucleotide binding]; other site 324057004864 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 324057004865 Catalytic site [active] 324057004866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057004867 sequence-specific DNA binding site [nucleotide binding]; other site 324057004868 salt bridge; other site 324057004869 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 324057004870 ORF6C domain; Region: ORF6C; pfam10552 324057004871 AAA domain; Region: AAA_23; pfam13476 324057004872 RecT family; Region: RecT; cl04285 324057004873 HNH endonuclease; Region: HNH_3; pfam13392 324057004874 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 324057004875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057004876 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 324057004877 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 324057004878 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 324057004879 replicative DNA helicase; Region: DnaB; TIGR00665 324057004880 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 324057004881 Walker A motif; other site 324057004882 ATP binding site [chemical binding]; other site 324057004883 Walker B motif; other site 324057004884 DNA binding loops [nucleotide binding] 324057004885 Helix-turn-helix domains; Region: HTH; cl00088 324057004886 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 324057004887 active site 324057004888 putative DNA-binding cleft [nucleotide binding]; other site 324057004889 dimer interface [polypeptide binding]; other site 324057004890 HNH endonuclease; Region: HNH_3; pfam13392 324057004891 dUTPase; Region: dUTPase_2; pfam08761 324057004892 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 324057004893 active site 324057004894 homodimer interface [polypeptide binding]; other site 324057004895 metal binding site [ion binding]; metal-binding site 324057004896 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 324057004897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057004898 cofactor binding site; other site 324057004899 DNA binding site [nucleotide binding] 324057004900 substrate interaction site [chemical binding]; other site 324057004901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057004902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057004903 positive control sigma-like factor; Validated; Region: PRK06930 324057004904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057004905 DNA binding residues [nucleotide binding] 324057004906 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057004907 catalytic residues [active] 324057004908 catalytic nucleophile [active] 324057004909 Recombinase; Region: Recombinase; pfam07508 324057004910 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324057004911 HupE / UreJ protein; Region: HupE_UreJ; cl01011 324057004912 KWG Leptospira; Region: KWG; pfam07656 324057004913 KWG Leptospira; Region: KWG; pfam07656 324057004914 flagellin; Validated; Region: PRK08026 324057004915 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057004916 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 324057004917 S-layer homology domain; Region: SLH; pfam00395 324057004918 S-layer homology domain; Region: SLH; pfam00395 324057004919 S-layer homology domain; Region: SLH; pfam00395 324057004920 BNR repeat-like domain; Region: BNR_2; pfam13088 324057004921 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 324057004922 Asp-box motif; other site 324057004923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057004924 DNA-binding site [nucleotide binding]; DNA binding site 324057004925 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 324057004926 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057004927 dimerization interface [polypeptide binding]; other site 324057004928 ligand binding site [chemical binding]; other site 324057004929 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057004930 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057004931 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057004932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057004934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004935 dimer interface [polypeptide binding]; other site 324057004936 conserved gate region; other site 324057004937 putative PBP binding loops; other site 324057004938 ABC-ATPase subunit interface; other site 324057004939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004941 dimer interface [polypeptide binding]; other site 324057004942 conserved gate region; other site 324057004943 putative PBP binding loops; other site 324057004944 ABC-ATPase subunit interface; other site 324057004945 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057004946 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 324057004947 BNR repeat-like domain; Region: BNR_2; pfam13088 324057004948 Asp-box motif; other site 324057004949 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 324057004950 BNR repeat-like domain; Region: BNR_2; pfam13088 324057004951 Asp-box motif; other site 324057004952 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 324057004953 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057004954 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057004955 active site 324057004956 non-prolyl cis peptide bond; other site 324057004957 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057004958 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 324057004959 Walker A/P-loop; other site 324057004960 ATP binding site [chemical binding]; other site 324057004961 Q-loop/lid; other site 324057004962 ABC transporter signature motif; other site 324057004963 Walker B; other site 324057004964 D-loop; other site 324057004965 H-loop/switch region; other site 324057004966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004967 ABC-ATPase subunit interface; other site 324057004968 NMT1-like family; Region: NMT1_2; cl15260 324057004969 Cupin domain; Region: Cupin_2; cl09118 324057004970 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004973 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057004974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057004975 active site 324057004976 catalytic tetrad [active] 324057004977 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 324057004978 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057004979 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057004980 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 324057004981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057004982 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 324057004983 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 324057004984 Walker A/P-loop; other site 324057004985 ATP binding site [chemical binding]; other site 324057004986 Q-loop/lid; other site 324057004987 ABC transporter signature motif; other site 324057004988 Walker B; other site 324057004989 D-loop; other site 324057004990 H-loop/switch region; other site 324057004991 FOG: CBS domain [General function prediction only]; Region: COG0517 324057004992 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 324057004993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057004994 NMT1-like family; Region: NMT1_2; cl15260 324057004995 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 324057004996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057004997 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 324057004998 active site 324057004999 ATP binding site [chemical binding]; other site 324057005000 substrate binding site [chemical binding]; other site 324057005001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057005002 Coenzyme A binding pocket [chemical binding]; other site 324057005003 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057005004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005005 NAD(P) binding site [chemical binding]; other site 324057005006 active site 324057005007 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057005008 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057005009 DNA binding residues [nucleotide binding] 324057005010 putative dimer interface [polypeptide binding]; other site 324057005011 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057005012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005013 Walker A/P-loop; other site 324057005014 ATP binding site [chemical binding]; other site 324057005015 Q-loop/lid; other site 324057005016 ABC transporter signature motif; other site 324057005017 Walker B; other site 324057005018 D-loop; other site 324057005019 H-loop/switch region; other site 324057005020 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057005021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005022 Walker A/P-loop; other site 324057005023 ATP binding site [chemical binding]; other site 324057005024 Q-loop/lid; other site 324057005025 ABC transporter signature motif; other site 324057005026 Walker B; other site 324057005027 D-loop; other site 324057005028 H-loop/switch region; other site 324057005029 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005032 Helix-turn-helix domains; Region: HTH; cl00088 324057005033 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057005034 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 324057005035 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 324057005036 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 324057005037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057005038 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057005039 active site 324057005040 catalytic residues [active] 324057005041 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057005042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057005043 DNA binding site [nucleotide binding] 324057005044 domain linker motif; other site 324057005045 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057005046 dimerization interface [polypeptide binding]; other site 324057005047 ligand binding site [chemical binding]; other site 324057005048 Cupin domain; Region: Cupin_2; cl09118 324057005049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005051 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 324057005052 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 324057005053 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057005054 dockerin binding interface; other site 324057005055 S-layer homology domain; Region: SLH; pfam00395 324057005056 S-layer homology domain; Region: SLH; pfam00395 324057005057 S-layer homology domain; Region: SLH; pfam00395 324057005058 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005059 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005061 dimer interface [polypeptide binding]; other site 324057005062 conserved gate region; other site 324057005063 putative PBP binding loops; other site 324057005064 ABC-ATPase subunit interface; other site 324057005065 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005067 dimer interface [polypeptide binding]; other site 324057005068 conserved gate region; other site 324057005069 putative PBP binding loops; other site 324057005070 ABC-ATPase subunit interface; other site 324057005071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005072 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005073 active site 324057005074 phosphorylation site [posttranslational modification] 324057005075 intermolecular recognition site; other site 324057005076 dimerization interface [polypeptide binding]; other site 324057005077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005078 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005082 dimerization interface [polypeptide binding]; other site 324057005083 Histidine kinase; Region: His_kinase; pfam06580 324057005084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005085 ATP binding site [chemical binding]; other site 324057005086 Mg2+ binding site [ion binding]; other site 324057005087 G-X-G motif; other site 324057005088 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005090 dimer interface [polypeptide binding]; other site 324057005091 conserved gate region; other site 324057005092 putative PBP binding loops; other site 324057005093 ABC-ATPase subunit interface; other site 324057005094 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005096 dimer interface [polypeptide binding]; other site 324057005097 conserved gate region; other site 324057005098 putative PBP binding loops; other site 324057005099 ABC-ATPase subunit interface; other site 324057005100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005101 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 324057005102 putative active site [active] 324057005103 putative catalytic site [active] 324057005104 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324057005105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057005107 DNA binding residues [nucleotide binding] 324057005108 dimerization interface [polypeptide binding]; other site 324057005109 Small acid-soluble spore protein H family; Region: SspH; cl06949 324057005110 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057005111 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057005112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005114 dimerization interface [polypeptide binding]; other site 324057005115 Histidine kinase; Region: His_kinase; pfam06580 324057005116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005117 ATP binding site [chemical binding]; other site 324057005118 Mg2+ binding site [ion binding]; other site 324057005119 G-X-G motif; other site 324057005120 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005122 active site 324057005123 phosphorylation site [posttranslational modification] 324057005124 intermolecular recognition site; other site 324057005125 dimerization interface [polypeptide binding]; other site 324057005126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005129 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005132 dimer interface [polypeptide binding]; other site 324057005133 conserved gate region; other site 324057005134 ABC-ATPase subunit interface; other site 324057005135 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005137 dimer interface [polypeptide binding]; other site 324057005138 conserved gate region; other site 324057005139 putative PBP binding loops; other site 324057005140 ABC-ATPase subunit interface; other site 324057005141 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 324057005142 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057005143 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057005144 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057005145 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 324057005146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057005147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005148 putative substrate translocation pore; other site 324057005149 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057005150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005151 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005153 dimer interface [polypeptide binding]; other site 324057005154 conserved gate region; other site 324057005155 ABC-ATPase subunit interface; other site 324057005156 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005158 dimer interface [polypeptide binding]; other site 324057005159 conserved gate region; other site 324057005160 putative PBP binding loops; other site 324057005161 ABC-ATPase subunit interface; other site 324057005162 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057005163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005164 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057005165 active site 324057005166 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057005167 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057005168 DNA binding residues [nucleotide binding] 324057005169 putative dimer interface [polypeptide binding]; other site 324057005170 short chain dehydrogenase; Provisional; Region: PRK06180 324057005171 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057005172 NADP binding site [chemical binding]; other site 324057005173 active site 324057005174 steroid binding site; other site 324057005175 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 324057005176 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057005177 classical (c) SDRs; Region: SDR_c; cd05233 324057005178 NAD(P) binding site [chemical binding]; other site 324057005179 active site 324057005180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057005181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057005182 DNA binding site [nucleotide binding] 324057005183 domain linker motif; other site 324057005184 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 324057005185 putative dimerization interface [polypeptide binding]; other site 324057005186 putative ligand binding site [chemical binding]; other site 324057005187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057005188 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 324057005189 active site 324057005190 motif I; other site 324057005191 motif II; other site 324057005192 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 324057005193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005194 dimerization interface [polypeptide binding]; other site 324057005195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057005196 dimer interface [polypeptide binding]; other site 324057005197 phosphorylation site [posttranslational modification] 324057005198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005199 ATP binding site [chemical binding]; other site 324057005200 Mg2+ binding site [ion binding]; other site 324057005201 G-X-G motif; other site 324057005202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057005203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005204 active site 324057005205 phosphorylation site [posttranslational modification] 324057005206 intermolecular recognition site; other site 324057005207 dimerization interface [polypeptide binding]; other site 324057005208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057005209 DNA binding site [nucleotide binding] 324057005210 Bacitracin resistance protein BacA; Region: BacA; cl00858 324057005211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324057005212 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 324057005213 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324057005214 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 324057005215 Protein export membrane protein; Region: SecD_SecF; cl14618 324057005216 Protein export membrane protein; Region: SecD_SecF; cl14618 324057005217 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 324057005218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057005219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057005220 DNA binding residues [nucleotide binding] 324057005221 Putative zinc-finger; Region: zf-HC2; cl15806 324057005222 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 324057005223 Sulfatase; Region: Sulfatase; cl10460 324057005224 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057005225 glutamate dehydrogenase; Provisional; Region: PRK09414 324057005226 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 324057005227 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 324057005228 NAD(P) binding site [chemical binding]; other site 324057005229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057005230 Helix-turn-helix domains; Region: HTH; cl00088 324057005231 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057005232 putative dimerization interface [polypeptide binding]; other site 324057005233 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057005234 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057005235 Spore germination protein; Region: Spore_permease; cl15802 324057005236 Putative motility protein; Region: YjfB_motility; pfam14070 324057005237 DoxX; Region: DoxX; cl00976 324057005238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057005239 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324057005240 substrate binding pocket [chemical binding]; other site 324057005241 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057005242 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324057005243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005244 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 324057005245 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057005246 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057005247 Walker A/P-loop; other site 324057005248 ATP binding site [chemical binding]; other site 324057005249 Q-loop/lid; other site 324057005250 ABC transporter signature motif; other site 324057005251 Walker B; other site 324057005252 D-loop; other site 324057005253 H-loop/switch region; other site 324057005254 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057005255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005256 dimer interface [polypeptide binding]; other site 324057005257 conserved gate region; other site 324057005258 putative PBP binding loops; other site 324057005259 ABC-ATPase subunit interface; other site 324057005260 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057005261 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057005262 active site 324057005263 non-prolyl cis peptide bond; other site 324057005264 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 324057005265 NMT1-like family; Region: NMT1_2; cl15260 324057005266 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057005267 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057005268 active site 324057005269 non-prolyl cis peptide bond; other site 324057005270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005271 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 324057005272 NAD(P) binding site [chemical binding]; other site 324057005273 active site 324057005274 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057005275 Helix-turn-helix domains; Region: HTH; cl00088 324057005276 WYL domain; Region: WYL; cl14852 324057005277 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057005278 active site 324057005279 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057005280 Ca binding site [ion binding]; other site 324057005281 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 324057005282 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 324057005283 dimer interface [polypeptide binding]; other site 324057005284 active site 324057005285 heme binding site [chemical binding]; other site 324057005286 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 324057005287 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005290 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005292 dimer interface [polypeptide binding]; other site 324057005293 conserved gate region; other site 324057005294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057005295 ABC-ATPase subunit interface; other site 324057005296 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005298 putative PBP binding loops; other site 324057005299 ABC-ATPase subunit interface; other site 324057005300 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057005301 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057005302 Metal-binding active site; metal-binding site 324057005303 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 324057005304 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057005305 MgtC family; Region: MgtC; pfam02308 324057005306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005307 VanZ like family; Region: VanZ; cl01971 324057005308 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005309 heme-binding site [chemical binding]; other site 324057005310 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005311 heme-binding site [chemical binding]; other site 324057005312 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005313 heme-binding site [chemical binding]; other site 324057005314 S-layer homology domain; Region: SLH; pfam00395 324057005315 S-layer homology domain; Region: SLH; pfam00395 324057005316 S-layer homology domain; Region: SLH; pfam00395 324057005317 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057005318 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005319 heme-binding site [chemical binding]; other site 324057005320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057005321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005322 active site 324057005323 phosphorylation site [posttranslational modification] 324057005324 intermolecular recognition site; other site 324057005325 dimerization interface [polypeptide binding]; other site 324057005326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057005327 DNA binding site [nucleotide binding] 324057005328 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 324057005329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005330 dimerization interface [polypeptide binding]; other site 324057005331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057005332 dimer interface [polypeptide binding]; other site 324057005333 phosphorylation site [posttranslational modification] 324057005334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005335 ATP binding site [chemical binding]; other site 324057005336 Mg2+ binding site [ion binding]; other site 324057005337 G-X-G motif; other site 324057005338 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 324057005339 putative active site [active] 324057005340 putative catalytic site [active] 324057005341 Cupin domain; Region: Cupin_2; cl09118 324057005342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005343 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005345 Cupin domain; Region: Cupin_2; cl09118 324057005346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005348 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057005349 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057005350 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057005351 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 324057005352 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005354 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005356 dimer interface [polypeptide binding]; other site 324057005357 conserved gate region; other site 324057005358 putative PBP binding loops; other site 324057005359 ABC-ATPase subunit interface; other site 324057005360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005362 dimer interface [polypeptide binding]; other site 324057005363 conserved gate region; other site 324057005364 ABC-ATPase subunit interface; other site 324057005365 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005366 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 324057005367 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057005368 Helix-turn-helix domains; Region: HTH; cl00088 324057005369 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057005370 haloalkane dehalogenase; Provisional; Region: PRK03592 324057005371 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005373 dimer interface [polypeptide binding]; other site 324057005374 conserved gate region; other site 324057005375 ABC-ATPase subunit interface; other site 324057005376 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005378 dimer interface [polypeptide binding]; other site 324057005379 conserved gate region; other site 324057005380 putative PBP binding loops; other site 324057005381 ABC-ATPase subunit interface; other site 324057005382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005383 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057005384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005385 active site 324057005386 phosphorylation site [posttranslational modification] 324057005387 intermolecular recognition site; other site 324057005388 dimerization interface [polypeptide binding]; other site 324057005389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005390 Histidine kinase; Region: His_kinase; pfam06580 324057005391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005392 ATP binding site [chemical binding]; other site 324057005393 Mg2+ binding site [ion binding]; other site 324057005394 G-X-G motif; other site 324057005395 alpha-glucosidase; Provisional; Region: PRK10137 324057005396 Cupin domain; Region: Cupin_2; cl09118 324057005397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005398 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005401 Helix-turn-helix domains; Region: HTH; cl00088 324057005402 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057005403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057005404 active site 324057005405 catalytic tetrad [active] 324057005406 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057005407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005408 dimerization interface [polypeptide binding]; other site 324057005409 Histidine kinase; Region: His_kinase; pfam06580 324057005410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005411 ATP binding site [chemical binding]; other site 324057005412 Mg2+ binding site [ion binding]; other site 324057005413 G-X-G motif; other site 324057005414 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 324057005415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005416 active site 324057005417 phosphorylation site [posttranslational modification] 324057005418 intermolecular recognition site; other site 324057005419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005422 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 324057005423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005424 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057005425 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 324057005426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005427 dimer interface [polypeptide binding]; other site 324057005428 conserved gate region; other site 324057005429 putative PBP binding loops; other site 324057005430 ABC-ATPase subunit interface; other site 324057005431 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005433 dimer interface [polypeptide binding]; other site 324057005434 conserved gate region; other site 324057005435 putative PBP binding loops; other site 324057005436 ABC-ATPase subunit interface; other site 324057005437 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057005438 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057005439 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057005440 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 324057005441 PPIC-type PPIASE domain; Region: Rotamase; cl08278 324057005442 Cupin domain; Region: Cupin_2; cl09118 324057005443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005446 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057005447 active site 324057005448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005451 dimer interface [polypeptide binding]; other site 324057005452 conserved gate region; other site 324057005453 ABC-ATPase subunit interface; other site 324057005454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005456 dimer interface [polypeptide binding]; other site 324057005457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057005458 ABC-ATPase subunit interface; other site 324057005459 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057005460 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057005461 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057005462 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057005463 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057005464 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057005465 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057005466 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057005467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005468 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057005469 active site 324057005470 ATP binding site [chemical binding]; other site 324057005471 substrate binding site [chemical binding]; other site 324057005472 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 324057005473 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057005474 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 324057005475 FAD binding pocket [chemical binding]; other site 324057005476 FAD binding motif [chemical binding]; other site 324057005477 catalytic residues [active] 324057005478 NAD binding pocket [chemical binding]; other site 324057005479 phosphate binding motif [ion binding]; other site 324057005480 beta-alpha-beta structure motif; other site 324057005481 sulfite reductase subunit beta; Provisional; Region: PRK13504 324057005482 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324057005483 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324057005484 Helix-turn-helix domains; Region: HTH; cl00088 324057005485 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057005486 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057005487 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 324057005488 D-mannonate oxidoreductase; Provisional; Region: PRK08277 324057005489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005490 NAD(P) binding site [chemical binding]; other site 324057005491 active site 324057005492 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 324057005493 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 324057005494 Ligand Binding Site [chemical binding]; other site 324057005495 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 324057005496 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 324057005497 N- and C-terminal domain interface [polypeptide binding]; other site 324057005498 putative active site [active] 324057005499 catalytic site [active] 324057005500 metal binding site [ion binding]; metal-binding site 324057005501 carbohydrate binding site [chemical binding]; other site 324057005502 ATP binding site [chemical binding]; other site 324057005503 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 324057005504 AIR carboxylase; Region: AIRC; cl00310 324057005505 High-affinity nickel-transport protein; Region: NicO; cl00964 324057005506 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057005507 Interdomain contacts; other site 324057005508 Cytokine receptor motif; other site 324057005509 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057005510 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 324057005511 Glyco_18 domain; Region: Glyco_18; smart00636 324057005512 active site 324057005513 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057005514 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005515 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 324057005516 Walker A/P-loop; other site 324057005517 ATP binding site [chemical binding]; other site 324057005518 Q-loop/lid; other site 324057005519 ABC transporter signature motif; other site 324057005520 Walker B; other site 324057005521 D-loop; other site 324057005522 H-loop/switch region; other site 324057005523 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 324057005524 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057005525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005526 FAD binding domain; Region: FAD_binding_3; pfam01494 324057005527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005528 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK06617 324057005529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005532 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005533 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324057005534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005535 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005537 dimer interface [polypeptide binding]; other site 324057005538 conserved gate region; other site 324057005539 ABC-ATPase subunit interface; other site 324057005540 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005542 dimer interface [polypeptide binding]; other site 324057005543 conserved gate region; other site 324057005544 putative PBP binding loops; other site 324057005545 ABC-ATPase subunit interface; other site 324057005546 Helix-turn-helix domains; Region: HTH; cl00088 324057005547 MFS transport protein AraJ; Provisional; Region: PRK10091 324057005548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005549 putative substrate translocation pore; other site 324057005550 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005552 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005554 dimer interface [polypeptide binding]; other site 324057005555 conserved gate region; other site 324057005556 ABC-ATPase subunit interface; other site 324057005557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005559 dimer interface [polypeptide binding]; other site 324057005560 conserved gate region; other site 324057005561 putative PBP binding loops; other site 324057005562 ABC-ATPase subunit interface; other site 324057005563 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005564 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 324057005565 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 324057005566 Walker A/P-loop; other site 324057005567 ATP binding site [chemical binding]; other site 324057005568 Q-loop/lid; other site 324057005569 ABC transporter signature motif; other site 324057005570 Walker B; other site 324057005571 D-loop; other site 324057005572 H-loop/switch region; other site 324057005573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005574 dimer interface [polypeptide binding]; other site 324057005575 conserved gate region; other site 324057005576 putative PBP binding loops; other site 324057005577 ABC-ATPase subunit interface; other site 324057005578 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 324057005579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005580 dimer interface [polypeptide binding]; other site 324057005581 conserved gate region; other site 324057005582 putative PBP binding loops; other site 324057005583 ABC-ATPase subunit interface; other site 324057005584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005585 acetylornithine deacetylase; Validated; Region: PRK08596 324057005586 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 324057005587 metal binding site [ion binding]; metal-binding site 324057005588 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057005589 DinB superfamily; Region: DinB_2; pfam12867 324057005590 Helix-turn-helix domains; Region: HTH; cl00088 324057005591 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 324057005592 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057005593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005594 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 324057005595 Walker A/P-loop; other site 324057005596 ATP binding site [chemical binding]; other site 324057005597 Q-loop/lid; other site 324057005598 ABC transporter signature motif; other site 324057005599 Walker B; other site 324057005600 D-loop; other site 324057005601 H-loop/switch region; other site 324057005602 YtxH-like protein; Region: YtxH; cl02079 324057005603 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 324057005604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057005605 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057005606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057005607 DNA binding residues [nucleotide binding] 324057005608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057005609 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 324057005610 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 324057005611 CHASE3 domain; Region: CHASE3; cl05000 324057005612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057005613 GAF domain; Region: GAF_2; pfam13185 324057005614 GAF domain; Region: GAF; cl15785 324057005615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057005616 dimer interface [polypeptide binding]; other site 324057005617 phosphorylation site [posttranslational modification] 324057005618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005619 ATP binding site [chemical binding]; other site 324057005620 Mg2+ binding site [ion binding]; other site 324057005621 G-X-G motif; other site 324057005622 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005624 active site 324057005625 phosphorylation site [posttranslational modification] 324057005626 intermolecular recognition site; other site 324057005627 dimerization interface [polypeptide binding]; other site 324057005628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057005629 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 324057005630 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057005631 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057005632 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 324057005633 N- and C-terminal domain interface [polypeptide binding]; other site 324057005634 D-xylulose kinase; Region: XylB; TIGR01312 324057005635 active site 324057005636 catalytic site [active] 324057005637 metal binding site [ion binding]; metal-binding site 324057005638 xylulose binding site [chemical binding]; other site 324057005639 putative ATP binding site [chemical binding]; other site 324057005640 homodimer interface [polypeptide binding]; other site 324057005641 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057005642 active site 324057005643 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057005644 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057005645 WYL domain; Region: WYL; cl14852 324057005646 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324057005647 Dynamin family; Region: Dynamin_N; pfam00350 324057005648 G1 box; other site 324057005649 GTP/Mg2+ binding site [chemical binding]; other site 324057005650 G2 box; other site 324057005651 Switch I region; other site 324057005652 G3 box; other site 324057005653 Switch II region; other site 324057005654 G4 box; other site 324057005655 G5 box; other site 324057005656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005657 Dynamin family; Region: Dynamin_N; pfam00350 324057005658 G1 box; other site 324057005659 GTP/Mg2+ binding site [chemical binding]; other site 324057005660 G2 box; other site 324057005661 Switch I region; other site 324057005662 G3 box; other site 324057005663 Switch II region; other site 324057005664 G4 box; other site 324057005665 G5 box; other site 324057005666 Domain of unknown function DUF87; Region: DUF87; pfam01935 324057005667 AAA-like domain; Region: AAA_10; pfam12846 324057005668 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324057005669 active site 324057005670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057005671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005673 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057005674 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057005675 active site 324057005676 metal binding site [ion binding]; metal-binding site 324057005677 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057005678 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057005679 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057005680 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 324057005681 dockerin binding interface; other site 324057005682 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057005683 dockerin binding interface; other site 324057005684 S-layer homology domain; Region: SLH; pfam00395 324057005685 S-layer homology domain; Region: SLH; pfam00395 324057005686 S-layer homology domain; Region: SLH; pfam00395 324057005687 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057005688 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057005689 ligand binding site [chemical binding]; other site 324057005690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005692 dimerization interface [polypeptide binding]; other site 324057005693 Histidine kinase; Region: His_kinase; pfam06580 324057005694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005695 ATP binding site [chemical binding]; other site 324057005696 Mg2+ binding site [ion binding]; other site 324057005697 G-X-G motif; other site 324057005698 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005700 active site 324057005701 phosphorylation site [posttranslational modification] 324057005702 intermolecular recognition site; other site 324057005703 dimerization interface [polypeptide binding]; other site 324057005704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005706 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 324057005707 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 324057005708 ligand binding site [chemical binding]; other site 324057005709 calcium binding site [ion binding]; other site 324057005710 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057005711 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 324057005712 Walker A/P-loop; other site 324057005713 ATP binding site [chemical binding]; other site 324057005714 Q-loop/lid; other site 324057005715 ABC transporter signature motif; other site 324057005716 Walker B; other site 324057005717 D-loop; other site 324057005718 H-loop/switch region; other site 324057005719 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057005720 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057005721 TM-ABC transporter signature motif; other site 324057005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057005723 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 324057005724 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324057005725 anti sigma factor interaction site; other site 324057005726 regulatory phosphorylation site [posttranslational modification]; other site 324057005727 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005729 active site 324057005730 phosphorylation site [posttranslational modification] 324057005731 intermolecular recognition site; other site 324057005732 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 324057005733 dimerization interface [polypeptide binding]; other site 324057005734 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 324057005735 Heat induced stress protein YflT; Region: YflT; pfam11181 324057005736 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 324057005737 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 324057005738 active site 324057005739 catalytic site [active] 324057005740 metal binding site [ion binding]; metal-binding site 324057005741 dimer interface [polypeptide binding]; other site 324057005742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005743 dimer interface [polypeptide binding]; other site 324057005744 conserved gate region; other site 324057005745 putative PBP binding loops; other site 324057005746 ABC-ATPase subunit interface; other site 324057005747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005748 dimer interface [polypeptide binding]; other site 324057005749 conserved gate region; other site 324057005750 putative PBP binding loops; other site 324057005751 ABC-ATPase subunit interface; other site 324057005752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005754 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057005755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057005756 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057005757 dimer interface [polypeptide binding]; other site 324057005758 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 324057005759 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 324057005760 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324057005761 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 324057005762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057005763 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 324057005764 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 324057005765 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057005766 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 324057005767 active site 324057005768 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057005769 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057005770 catalytic core [active] 324057005771 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057005772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005773 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057005774 putative substrate translocation pore; other site 324057005775 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057005776 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 324057005777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057005778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057005779 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057005780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005781 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057005782 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005784 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057005785 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057005791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005792 putative substrate translocation pore; other site 324057005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005794 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 324057005795 AAA domain; Region: AAA_18; pfam13238 324057005796 ATP-binding site [chemical binding]; other site 324057005797 Sugar specificity; other site 324057005798 Pyrimidine base specificity; other site 324057005799 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 324057005800 uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 324057005801 N- and C-terminal domain interface [polypeptide binding]; other site 324057005802 active site 324057005803 catalytic site [active] 324057005804 metal binding site [ion binding]; metal-binding site 324057005805 xylulose binding site [chemical binding]; other site 324057005806 ATP binding site [chemical binding]; other site 324057005807 putative homodimer interface [polypeptide binding]; other site 324057005808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005809 putative substrate translocation pore; other site 324057005810 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057005811 intersubunit interface [polypeptide binding]; other site 324057005812 active site 324057005813 Zn2+ binding site [ion binding]; other site 324057005814 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057005815 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 324057005816 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057005817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057005818 catalytic residue [active] 324057005819 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 324057005820 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 324057005821 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057005822 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 324057005823 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057005824 active site 324057005825 metal binding site [ion binding]; metal-binding site 324057005826 hexamer interface [polypeptide binding]; other site 324057005827 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057005828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057005829 DNA-binding site [nucleotide binding]; DNA binding site 324057005830 FCD domain; Region: FCD; cl11656 324057005831 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057005832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057005833 DNA-binding site [nucleotide binding]; DNA binding site 324057005834 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057005835 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057005836 Walker A/P-loop; other site 324057005837 ATP binding site [chemical binding]; other site 324057005838 Q-loop/lid; other site 324057005839 ABC transporter signature motif; other site 324057005840 Walker B; other site 324057005841 D-loop; other site 324057005842 H-loop/switch region; other site 324057005843 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057005844 Helix-turn-helix domains; Region: HTH; cl00088 324057005845 AsnC family; Region: AsnC_trans_reg; pfam01037 324057005846 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057005847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057005848 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057005849 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 324057005850 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057005851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057005852 ATP binding site [chemical binding]; other site 324057005853 putative Mg++ binding site [ion binding]; other site 324057005854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057005855 nucleotide binding region [chemical binding]; other site 324057005856 ATP-binding site [chemical binding]; other site 324057005857 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057005858 Helix-turn-helix domains; Region: HTH; cl00088 324057005859 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057005860 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 324057005861 putative NAD(P) binding site [chemical binding]; other site 324057005862 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 324057005863 substrate binding site [chemical binding]; other site 324057005864 active site 324057005865 BclB C-terminal domain; Region: exospore_TM; TIGR03721 324057005866 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057005867 putative metal binding site; other site 324057005868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057005869 binding surface 324057005870 TPR motif; other site 324057005871 Cupin domain; Region: Cupin_2; cl09118 324057005872 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005875 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057005876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057005877 Helix-turn-helix domains; Region: HTH; cl00088 324057005878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057005879 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057005880 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057005881 Walker A/P-loop; other site 324057005882 ATP binding site [chemical binding]; other site 324057005883 Q-loop/lid; other site 324057005884 ABC transporter signature motif; other site 324057005885 Walker B; other site 324057005886 D-loop; other site 324057005887 H-loop/switch region; other site 324057005888 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 324057005889 short chain dehydrogenase; Provisional; Region: PRK06701 324057005890 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 324057005891 NAD binding site [chemical binding]; other site 324057005892 metal binding site [ion binding]; metal-binding site 324057005893 active site 324057005894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057005895 Helix-turn-helix domains; Region: HTH; cl00088 324057005896 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 324057005897 putative dimerization interface [polypeptide binding]; other site 324057005898 LrgA family; Region: LrgA; cl00608 324057005899 LrgB-like family; Region: LrgB; cl00596 324057005900 EamA-like transporter family; Region: EamA; cl01037 324057005901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057005902 non-specific DNA binding site [nucleotide binding]; other site 324057005903 salt bridge; other site 324057005904 sequence-specific DNA binding site [nucleotide binding]; other site 324057005905 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057005906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057005907 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324057005908 active site 324057005909 NTP binding site [chemical binding]; other site 324057005910 metal binding triad [ion binding]; metal-binding site 324057005911 antibiotic binding site [chemical binding]; other site 324057005912 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 324057005913 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 324057005914 active site 324057005915 HIGH motif; other site 324057005916 dimer interface [polypeptide binding]; other site 324057005917 KMSKS motif; other site 324057005918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 324057005919 Protein of unknown function (DUF419); Region: DUF419; cl15265 324057005920 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057005921 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 324057005922 Cupin domain; Region: Cupin_2; cl09118 324057005923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005924 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005926 putative alpha-glucosidase; Provisional; Region: PRK10658 324057005927 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 324057005928 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 324057005929 active site 324057005930 homotrimer interface [polypeptide binding]; other site 324057005931 catalytic site [active] 324057005932 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 324057005933 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057005934 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057005935 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057005936 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057005937 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057005938 ligand binding site [chemical binding]; other site 324057005939 metal binding site [ion binding]; metal-binding site 324057005940 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057005941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005942 dimerization interface [polypeptide binding]; other site 324057005943 Histidine kinase; Region: His_kinase; pfam06580 324057005944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005945 ATP binding site [chemical binding]; other site 324057005946 Mg2+ binding site [ion binding]; other site 324057005947 G-X-G motif; other site 324057005948 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057005949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005950 active site 324057005951 phosphorylation site [posttranslational modification] 324057005952 intermolecular recognition site; other site 324057005953 dimerization interface [polypeptide binding]; other site 324057005954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005956 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005958 dimer interface [polypeptide binding]; other site 324057005959 conserved gate region; other site 324057005960 ABC-ATPase subunit interface; other site 324057005961 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005963 dimer interface [polypeptide binding]; other site 324057005964 conserved gate region; other site 324057005965 ABC-ATPase subunit interface; other site 324057005966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005968 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324057005969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057005970 Histidine kinase; Region: His_kinase; pfam06580 324057005971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057005972 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 324057005973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005974 active site 324057005975 phosphorylation site [posttranslational modification] 324057005976 intermolecular recognition site; other site 324057005977 dimerization interface [polypeptide binding]; other site 324057005978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057005982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005983 dimer interface [polypeptide binding]; other site 324057005984 conserved gate region; other site 324057005985 ABC-ATPase subunit interface; other site 324057005986 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005988 dimer interface [polypeptide binding]; other site 324057005989 conserved gate region; other site 324057005990 putative PBP binding loops; other site 324057005991 ABC-ATPase subunit interface; other site 324057005992 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 324057005993 putative transposase OrfB; Reviewed; Region: PHA02517 324057005994 HTH-like domain; Region: HTH_21; pfam13276 324057005995 Integrase core domain; Region: rve; cl01316 324057005996 Integrase core domain; Region: rve_3; cl15866 324057005997 Helix-turn-helix domains; Region: HTH; cl00088 324057005998 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 324057005999 dimer interface [polypeptide binding]; other site 324057006000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057006001 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 324057006002 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057006003 PYR/PP interface [polypeptide binding]; other site 324057006004 dimer interface [polypeptide binding]; other site 324057006005 TPP binding site [chemical binding]; other site 324057006006 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 324057006007 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 324057006008 TPP-binding site; other site 324057006009 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057006010 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057006011 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 324057006012 substrate binding site [chemical binding]; other site 324057006013 ATP binding site [chemical binding]; other site 324057006014 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 324057006015 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324057006016 tetrameric interface [polypeptide binding]; other site 324057006017 NAD binding site [chemical binding]; other site 324057006018 catalytic residues [active] 324057006019 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057006020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006021 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057006022 KduI/IolB family; Region: KduI; cl01508 324057006023 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057006024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057006025 DNA binding site [nucleotide binding] 324057006026 domain linker motif; other site 324057006027 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057006028 dimerization interface [polypeptide binding]; other site 324057006029 ligand binding site [chemical binding]; other site 324057006030 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057006031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057006032 DNA-binding site [nucleotide binding]; DNA binding site 324057006033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057006034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057006035 homodimer interface [polypeptide binding]; other site 324057006036 catalytic residue [active] 324057006037 Helix-turn-helix domains; Region: HTH; cl00088 324057006038 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057006039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057006040 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 324057006041 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 324057006042 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 324057006043 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057006044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006045 NAD(P) binding site [chemical binding]; other site 324057006046 active site 324057006047 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057006048 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057006049 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057006050 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057006051 S-layer homology domain; Region: SLH; pfam00395 324057006052 S-layer homology domain; Region: SLH; pfam00395 324057006053 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057006054 hydrophobic ligand binding site; other site 324057006055 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 324057006056 GIY-YIG motif/motif A; other site 324057006057 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057006058 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057006059 Spore germination protein; Region: Spore_permease; cl15802 324057006060 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057006061 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057006062 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324057006063 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324057006064 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324057006065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006066 Helix-turn-helix domains; Region: HTH; cl00088 324057006067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057006068 dimerization interface [polypeptide binding]; other site 324057006069 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057006070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006072 dimer interface [polypeptide binding]; other site 324057006073 conserved gate region; other site 324057006074 putative PBP binding loops; other site 324057006075 ABC-ATPase subunit interface; other site 324057006076 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057006078 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057006079 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 324057006080 Walker A/P-loop; other site 324057006081 ATP binding site [chemical binding]; other site 324057006082 Q-loop/lid; other site 324057006083 ABC transporter signature motif; other site 324057006084 Walker B; other site 324057006085 D-loop; other site 324057006086 H-loop/switch region; other site 324057006087 Cupin domain; Region: Cupin_2; cl09118 324057006088 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 324057006089 Cupin domain; Region: Cupin_2; cl09118 324057006090 Cupin domain; Region: Cupin_2; cl09118 324057006091 Pirin-related protein [General function prediction only]; Region: COG1741 324057006092 Cupin domain; Region: Cupin_2; cl09118 324057006093 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 324057006094 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 324057006095 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 324057006096 active site 324057006097 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057006098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006099 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057006100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057006101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006103 dimerization interface [polypeptide binding]; other site 324057006104 Histidine kinase; Region: His_kinase; pfam06580 324057006105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006106 ATP binding site [chemical binding]; other site 324057006107 Mg2+ binding site [ion binding]; other site 324057006108 G-X-G motif; other site 324057006109 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006111 active site 324057006112 phosphorylation site [posttranslational modification] 324057006113 intermolecular recognition site; other site 324057006114 dimerization interface [polypeptide binding]; other site 324057006115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006118 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006120 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057006121 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057006123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006125 dimer interface [polypeptide binding]; other site 324057006126 ABC-ATPase subunit interface; other site 324057006127 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006128 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057006129 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057006130 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 324057006131 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 324057006132 S-layer homology domain; Region: SLH; pfam00395 324057006133 S-layer homology domain; Region: SLH; pfam00395 324057006134 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057006135 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057006136 dockerin binding interface; other site 324057006137 S-layer homology domain; Region: SLH; pfam00395 324057006138 S-layer homology domain; Region: SLH; pfam00395 324057006139 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057006140 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057006141 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057006142 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057006143 dockerin binding interface; other site 324057006144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057006145 Histidine kinase; Region: His_kinase; pfam06580 324057006146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006147 ATP binding site [chemical binding]; other site 324057006148 Mg2+ binding site [ion binding]; other site 324057006149 G-X-G motif; other site 324057006150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006151 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057006152 active site 324057006153 phosphorylation site [posttranslational modification] 324057006154 intermolecular recognition site; other site 324057006155 dimerization interface [polypeptide binding]; other site 324057006156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006158 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057006161 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006164 dimer interface [polypeptide binding]; other site 324057006165 conserved gate region; other site 324057006166 putative PBP binding loops; other site 324057006167 ABC-ATPase subunit interface; other site 324057006168 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324057006169 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324057006170 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 324057006171 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 324057006172 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057006173 dimerization domain swap beta strand [polypeptide binding]; other site 324057006174 regulatory protein interface [polypeptide binding]; other site 324057006175 active site 324057006176 regulatory phosphorylation site [posttranslational modification]; other site 324057006177 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 324057006178 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 324057006179 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324057006180 active site turn [active] 324057006181 phosphorylation site [posttranslational modification] 324057006182 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 324057006183 HPr interaction site; other site 324057006184 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324057006185 active site 324057006186 phosphorylation site [posttranslational modification] 324057006187 transcriptional antiterminator BglG; Provisional; Region: PRK09772 324057006188 CAT RNA binding domain; Region: CAT_RBD; cl03904 324057006189 PRD domain; Region: PRD; cl15445 324057006190 PRD domain; Region: PRD; cl15445 324057006191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057006192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057006193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006194 NAD(P) binding site [chemical binding]; other site 324057006195 active site 324057006196 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057006197 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057006198 EamA-like transporter family; Region: EamA; cl01037 324057006199 EamA-like transporter family; Region: EamA; cl01037 324057006200 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057006201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006202 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057006203 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 324057006204 nudix motif; other site 324057006205 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324057006206 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324057006207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057006208 active site 324057006209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006210 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006212 dimer interface [polypeptide binding]; other site 324057006213 conserved gate region; other site 324057006214 putative PBP binding loops; other site 324057006215 ABC-ATPase subunit interface; other site 324057006216 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006218 dimer interface [polypeptide binding]; other site 324057006219 conserved gate region; other site 324057006220 putative PBP binding loops; other site 324057006221 ABC-ATPase subunit interface; other site 324057006222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006224 dimerization interface [polypeptide binding]; other site 324057006225 Histidine kinase; Region: His_kinase; pfam06580 324057006226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006227 ATP binding site [chemical binding]; other site 324057006228 Mg2+ binding site [ion binding]; other site 324057006229 G-X-G motif; other site 324057006230 Response regulator receiver domain; Region: Response_reg; pfam00072 324057006231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006232 active site 324057006233 phosphorylation site [posttranslational modification] 324057006234 intermolecular recognition site; other site 324057006235 dimerization interface [polypeptide binding]; other site 324057006236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006237 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006239 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 324057006240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006241 NAD(P) binding site [chemical binding]; other site 324057006242 active site 324057006243 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057006244 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057006245 DNA binding residues [nucleotide binding] 324057006246 putative dimer interface [polypeptide binding]; other site 324057006247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006248 Coenzyme A binding pocket [chemical binding]; other site 324057006249 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 324057006250 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 324057006251 active site residue [active] 324057006252 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 324057006253 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 324057006254 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 324057006255 active site residue [active] 324057006256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006257 Helix-turn-helix domains; Region: HTH; cl00088 324057006258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057006259 dimerization interface [polypeptide binding]; other site 324057006260 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 324057006261 Tetramer interface [polypeptide binding]; other site 324057006262 active site 324057006263 FMN-binding site [chemical binding]; other site 324057006264 Integral membrane protein TerC family; Region: TerC; cl10468 324057006265 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057006266 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057006267 metal binding site [ion binding]; metal-binding site 324057006268 active site 324057006269 aconitate hydratase; Validated; Region: PRK09277 324057006270 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 324057006271 substrate binding site [chemical binding]; other site 324057006272 ligand binding site [chemical binding]; other site 324057006273 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 324057006274 substrate binding site [chemical binding]; other site 324057006275 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057006276 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 324057006277 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 324057006278 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 324057006279 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 324057006280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006281 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 324057006282 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057006283 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 324057006284 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 324057006285 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057006286 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 324057006287 active site 324057006288 ATP binding site [chemical binding]; other site 324057006289 CotH protein; Region: CotH; pfam08757 324057006290 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 324057006291 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 324057006292 putative metal binding residues [ion binding]; other site 324057006293 signature motif; other site 324057006294 dimer interface [polypeptide binding]; other site 324057006295 active site 324057006296 polyP binding site; other site 324057006297 substrate binding site [chemical binding]; other site 324057006298 acceptor-phosphate pocket; other site 324057006299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057006300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006301 dimer interface [polypeptide binding]; other site 324057006302 phosphorylation site [posttranslational modification] 324057006303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006304 ATP binding site [chemical binding]; other site 324057006305 Mg2+ binding site [ion binding]; other site 324057006306 G-X-G motif; other site 324057006307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057006308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006309 active site 324057006310 phosphorylation site [posttranslational modification] 324057006311 intermolecular recognition site; other site 324057006312 dimerization interface [polypeptide binding]; other site 324057006313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057006314 DNA binding site [nucleotide binding] 324057006315 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057006316 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 324057006317 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 324057006318 putative metal binding site [ion binding]; other site 324057006319 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057006320 active site 324057006321 metal binding site [ion binding]; metal-binding site 324057006322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006323 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057006324 active site 324057006325 motif I; other site 324057006326 motif II; other site 324057006327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006328 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 324057006329 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324057006330 DHHA2 domain; Region: DHHA2; pfam02833 324057006331 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 324057006332 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057006333 NlpC/P60 family; Region: NLPC_P60; cl11438 324057006334 Helix-turn-helix domains; Region: HTH; cl00088 324057006335 Helix-turn-helix domains; Region: HTH; cl00088 324057006336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057006337 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057006338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006339 Walker A/P-loop; other site 324057006340 ATP binding site [chemical binding]; other site 324057006341 Q-loop/lid; other site 324057006342 ABC transporter signature motif; other site 324057006343 Walker B; other site 324057006344 D-loop; other site 324057006345 H-loop/switch region; other site 324057006346 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057006347 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 324057006348 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 324057006349 Walker A/P-loop; other site 324057006350 ATP binding site [chemical binding]; other site 324057006351 Q-loop/lid; other site 324057006352 ABC transporter signature motif; other site 324057006353 Walker B; other site 324057006354 D-loop; other site 324057006355 H-loop/switch region; other site 324057006356 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057006357 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057006358 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057006359 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 324057006360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006361 motif II; other site 324057006362 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006364 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057006365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006366 dimer interface [polypeptide binding]; other site 324057006367 conserved gate region; other site 324057006368 putative PBP binding loops; other site 324057006369 ABC-ATPase subunit interface; other site 324057006370 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006372 dimer interface [polypeptide binding]; other site 324057006373 conserved gate region; other site 324057006374 putative PBP binding loops; other site 324057006375 ABC-ATPase subunit interface; other site 324057006376 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057006377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006378 dimerization interface [polypeptide binding]; other site 324057006379 Histidine kinase; Region: His_kinase; pfam06580 324057006380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006381 ATP binding site [chemical binding]; other site 324057006382 Mg2+ binding site [ion binding]; other site 324057006383 G-X-G motif; other site 324057006384 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057006385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006386 active site 324057006387 phosphorylation site [posttranslational modification] 324057006388 intermolecular recognition site; other site 324057006389 dimerization interface [polypeptide binding]; other site 324057006390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006392 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006395 Coenzyme A binding pocket [chemical binding]; other site 324057006396 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057006398 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006399 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006401 dimer interface [polypeptide binding]; other site 324057006402 ABC-ATPase subunit interface; other site 324057006403 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057006404 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006406 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057006407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057006408 Holin family; Region: Phage_holin_4; cl01989 324057006409 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057006410 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 324057006411 Protein of unknown function DUF86; Region: DUF86; cl01031 324057006412 Predicted transcriptional regulator [Transcription]; Region: COG2345 324057006413 Helix-turn-helix domains; Region: HTH; cl00088 324057006414 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 324057006415 YtxH-like protein; Region: YtxH; cl02079 324057006416 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057006417 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324057006418 Helix-turn-helix domains; Region: HTH; cl00088 324057006419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006421 putative substrate translocation pore; other site 324057006422 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 324057006423 active site 324057006424 Zn binding site [ion binding]; other site 324057006425 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 324057006426 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 324057006427 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057006428 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 324057006429 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057006430 Sulfatase; Region: Sulfatase; cl10460 324057006431 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 324057006432 THUMP domain; Region: THUMP; cl12076 324057006433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057006434 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 324057006435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057006436 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 324057006437 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 324057006438 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 324057006439 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057006440 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 324057006441 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 324057006442 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 324057006443 Walker A motif; other site 324057006444 ATP binding site [chemical binding]; other site 324057006445 Walker B motif; other site 324057006446 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 324057006447 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006448 Walker A motif; other site 324057006449 ATP binding site [chemical binding]; other site 324057006450 Walker B motif; other site 324057006451 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 324057006452 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 324057006453 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 324057006454 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 324057006455 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 324057006456 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 324057006457 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 324057006458 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 324057006459 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 324057006460 substrate binding site [chemical binding]; other site 324057006461 active site 324057006462 ferrochelatase; Provisional; Region: PRK12435 324057006463 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 324057006464 C-terminal domain interface [polypeptide binding]; other site 324057006465 active site 324057006466 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 324057006467 active site 324057006468 N-terminal domain interface [polypeptide binding]; other site 324057006469 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 324057006470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006471 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057006472 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057006473 putative active site [active] 324057006474 putative metal binding site [ion binding]; other site 324057006475 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057006476 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 324057006477 active site 324057006478 catalytic site [active] 324057006479 Integral membrane protein DUF92; Region: DUF92; cl00793 324057006480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057006481 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 324057006482 dimer interface [polypeptide binding]; other site 324057006483 putative metal binding site [ion binding]; other site 324057006484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057006485 S-adenosylmethionine binding site [chemical binding]; other site 324057006486 Putative cyclase; Region: Cyclase; cl00814 324057006487 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 324057006488 oligoendopeptidase F; Region: pepF; TIGR00181 324057006489 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 324057006490 active site 324057006491 Zn binding site [ion binding]; other site 324057006492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057006493 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 324057006494 DNA-binding site [nucleotide binding]; DNA binding site 324057006495 RNA-binding motif; other site 324057006496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006497 phenyl proprionate permease family protein; Region: 2A0127; TIGR00902 324057006498 putative substrate translocation pore; other site 324057006499 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 324057006500 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 324057006501 active site 324057006502 ADP/pyrophosphate binding site [chemical binding]; other site 324057006503 dimerization interface [polypeptide binding]; other site 324057006504 allosteric effector site; other site 324057006505 fructose-1,6-bisphosphate binding site; other site 324057006506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057006507 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057006508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006509 Walker A/P-loop; other site 324057006510 ATP binding site [chemical binding]; other site 324057006511 Q-loop/lid; other site 324057006512 ABC transporter signature motif; other site 324057006513 Walker B; other site 324057006514 D-loop; other site 324057006515 H-loop/switch region; other site 324057006516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057006517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006518 active site 324057006519 phosphorylation site [posttranslational modification] 324057006520 intermolecular recognition site; other site 324057006521 dimerization interface [polypeptide binding]; other site 324057006522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057006523 DNA binding site [nucleotide binding] 324057006524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006525 dimer interface [polypeptide binding]; other site 324057006526 phosphorylation site [posttranslational modification] 324057006527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006528 ATP binding site [chemical binding]; other site 324057006529 Mg2+ binding site [ion binding]; other site 324057006530 G-X-G motif; other site 324057006531 methyl-accepting protein IV; Provisional; Region: PRK09793 324057006532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006533 dimerization interface [polypeptide binding]; other site 324057006534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006535 dimer interface [polypeptide binding]; other site 324057006536 phosphorylation site [posttranslational modification] 324057006537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006538 ATP binding site [chemical binding]; other site 324057006539 Mg2+ binding site [ion binding]; other site 324057006540 G-X-G motif; other site 324057006541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057006542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006543 active site 324057006544 phosphorylation site [posttranslational modification] 324057006545 intermolecular recognition site; other site 324057006546 dimerization interface [polypeptide binding]; other site 324057006547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057006548 DNA binding site [nucleotide binding] 324057006549 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324057006550 Protein export membrane protein; Region: SecD_SecF; cl14618 324057006551 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 324057006552 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057006553 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057006554 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057006555 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 324057006556 helicase 45; Provisional; Region: PTZ00424 324057006557 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057006558 ATP binding site [chemical binding]; other site 324057006559 Mg++ binding site [ion binding]; other site 324057006560 motif III; other site 324057006561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057006562 nucleotide binding region [chemical binding]; other site 324057006563 ATP-binding site [chemical binding]; other site 324057006564 Protein of unknown function, DUF624; Region: DUF624; cl02369 324057006565 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 324057006566 dimer interface [polypeptide binding]; other site 324057006567 catalytic triad [active] 324057006568 peroxidatic and resolving cysteines [active] 324057006569 Rhomboid family; Region: Rhomboid; cl11446 324057006570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006571 Helix-turn-helix domains; Region: HTH; cl00088 324057006572 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057006573 putative dimerization interface [polypeptide binding]; other site 324057006574 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 324057006575 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057006576 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057006577 DNA binding residues [nucleotide binding] 324057006578 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 324057006579 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 324057006580 metal binding triad; other site 324057006581 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 324057006582 hypothetical protein; Provisional; Region: PRK07740 324057006583 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324057006584 active site 324057006585 catalytic site [active] 324057006586 substrate binding site [chemical binding]; other site 324057006587 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 324057006588 MPN+ (JAMM) motif; other site 324057006589 Zinc-binding site [ion binding]; other site 324057006590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006592 putative substrate translocation pore; other site 324057006593 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 324057006594 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324057006595 catalytic residues [active] 324057006596 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 324057006597 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 324057006598 active site 324057006599 catalytic residues [active] 324057006600 metal binding site [ion binding]; metal-binding site 324057006601 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 324057006602 DNA polymerase IV; Validated; Region: PRK01810 324057006603 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 324057006604 active site 324057006605 DNA binding site [nucleotide binding] 324057006606 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 324057006607 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 324057006608 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 324057006609 quinone interaction residues [chemical binding]; other site 324057006610 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 324057006611 active site 324057006612 catalytic residues [active] 324057006613 FMN binding site [chemical binding]; other site 324057006614 substrate binding site [chemical binding]; other site 324057006615 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324057006616 synthetase active site [active] 324057006617 NTP binding site [chemical binding]; other site 324057006618 metal binding site [ion binding]; metal-binding site 324057006619 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057006620 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057006621 DNA binding site [nucleotide binding] 324057006622 domain linker motif; other site 324057006623 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057006624 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 324057006625 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 324057006626 dimerization interface [polypeptide binding]; other site 324057006627 putative active cleft [active] 324057006628 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057006629 active site 324057006630 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 324057006631 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057006632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057006633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006634 Helix-turn-helix domains; Region: HTH; cl00088 324057006635 Predicted membrane protein [Function unknown]; Region: COG1511 324057006636 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057006637 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057006638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 324057006639 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 324057006640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057006641 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057006642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057006643 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 324057006644 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324057006645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057006646 RNA binding surface [nucleotide binding]; other site 324057006647 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 324057006648 active site 324057006649 uracil binding [chemical binding]; other site 324057006650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006651 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057006652 active site 324057006653 motif I; other site 324057006654 motif II; other site 324057006655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006656 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 324057006657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057006658 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 324057006659 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057006660 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324057006661 ATP binding site [chemical binding]; other site 324057006662 Mg++ binding site [ion binding]; other site 324057006663 motif III; other site 324057006664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057006665 nucleotide binding region [chemical binding]; other site 324057006666 ATP-binding site [chemical binding]; other site 324057006667 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 324057006668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006669 Coenzyme A binding pocket [chemical binding]; other site 324057006670 LysE type translocator; Region: LysE; cl00565 324057006671 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 324057006672 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324057006673 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 324057006674 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 324057006675 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 324057006676 dimer interface [polypeptide binding]; other site 324057006677 putative functional site; other site 324057006678 putative MPT binding site; other site 324057006679 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 324057006680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057006681 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 324057006682 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 324057006683 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 324057006684 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 324057006685 [4Fe-4S] binding site [ion binding]; other site 324057006686 molybdopterin cofactor binding site; other site 324057006687 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 324057006688 molybdopterin cofactor binding site; other site 324057006689 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 324057006690 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 324057006691 GTP binding site; other site 324057006692 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 324057006693 Walker A motif; other site 324057006694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006696 dimer interface [polypeptide binding]; other site 324057006697 phosphorylation site [posttranslational modification] 324057006698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006699 ATP binding site [chemical binding]; other site 324057006700 Mg2+ binding site [ion binding]; other site 324057006701 G-X-G motif; other site 324057006702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057006703 Helix-turn-helix domains; Region: HTH; cl00088 324057006704 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006705 arsenical pump membrane protein; Provisional; Region: PRK15445 324057006706 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 324057006707 transmembrane helices; other site 324057006708 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324057006709 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 324057006710 active site 324057006711 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 324057006712 Predicted membrane protein [Function unknown]; Region: COG3766 324057006713 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 324057006714 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 324057006715 HIGH motif; other site 324057006716 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324057006717 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057006718 active site 324057006719 KMSKS motif; other site 324057006720 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 324057006721 tRNA binding surface [nucleotide binding]; other site 324057006722 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 324057006723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006724 NAD(P) binding pocket [chemical binding]; other site 324057006725 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 324057006726 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 324057006727 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 324057006728 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057006729 homodimer interface [polypeptide binding]; other site 324057006730 substrate-cofactor binding pocket; other site 324057006731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057006732 catalytic residue [active] 324057006733 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 324057006734 catalytic motif [active] 324057006735 Zn binding site [ion binding]; other site 324057006736 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 324057006737 Competence protein; Region: Competence; cl00471 324057006738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057006739 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 324057006740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057006741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057006742 DNA binding residues [nucleotide binding] 324057006743 Putative zinc-finger; Region: zf-HC2; cl15806 324057006744 Microtubule associated protein (MAP65/ASE1 family); Region: MAP65_ASE1; pfam03999 324057006745 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 324057006746 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 324057006747 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 324057006748 Germination protease; Region: Peptidase_A25; cl04057 324057006749 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 324057006750 stage II sporulation protein P; Region: spore_II_P; TIGR02867 324057006751 GTP-binding protein LepA; Provisional; Region: PRK05433 324057006752 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 324057006753 G1 box; other site 324057006754 putative GEF interaction site [polypeptide binding]; other site 324057006755 GTP/Mg2+ binding site [chemical binding]; other site 324057006756 Switch I region; other site 324057006757 G2 box; other site 324057006758 G3 box; other site 324057006759 Switch II region; other site 324057006760 G4 box; other site 324057006761 G5 box; other site 324057006762 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 324057006763 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 324057006764 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 324057006765 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 324057006766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057006767 FeS/SAM binding site; other site 324057006768 HemN C-terminal domain; Region: HemN_C; pfam06969 324057006769 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 324057006770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006771 Coenzyme A binding pocket [chemical binding]; other site 324057006772 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 324057006773 Helix-turn-helix domains; Region: HTH; cl00088 324057006774 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 324057006775 dimer interface [polypeptide binding]; other site 324057006776 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 324057006777 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 324057006778 chaperone protein DnaJ; Provisional; Region: PRK14280 324057006779 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324057006780 HSP70 interaction site [polypeptide binding]; other site 324057006781 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 324057006782 substrate binding site [polypeptide binding]; other site 324057006783 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 324057006784 Zn binding sites [ion binding]; other site 324057006785 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 324057006786 dimer interface [polypeptide binding]; other site 324057006787 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 324057006788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057006789 S-adenosylmethionine binding site [chemical binding]; other site 324057006790 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 324057006791 active site 324057006792 putative substrate binding region [chemical binding]; other site 324057006793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 324057006794 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 324057006795 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 324057006796 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 324057006797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057006798 FeS/SAM binding site; other site 324057006799 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 324057006800 active site 324057006801 Ap6A binding site [chemical binding]; other site 324057006802 nudix motif; other site 324057006803 metal binding site [ion binding]; metal-binding site 324057006804 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 324057006805 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 324057006806 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 324057006807 PUA domain; Region: PUA; cl00607 324057006808 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 324057006809 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 324057006810 putative RNA binding site [nucleotide binding]; other site 324057006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057006812 S-adenosylmethionine binding site [chemical binding]; other site 324057006813 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 324057006814 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 324057006815 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 324057006816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006817 Family description; Region: UvrD_C_2; cl15862 324057006818 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 324057006819 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 324057006820 nucleotide binding site/active site [active] 324057006821 HIT family signature motif; other site 324057006822 catalytic residue [active] 324057006823 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 324057006824 GatB domain; Region: GatB_Yqey; cl11497 324057006825 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 324057006826 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 324057006827 dimer interface [polypeptide binding]; other site 324057006828 active site residues [active] 324057006829 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 324057006830 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 324057006831 YabP family; Region: YabP; cl06766 324057006832 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 324057006833 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 324057006834 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 324057006835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006836 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 324057006837 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 324057006838 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057006839 Zn2+ binding site [ion binding]; other site 324057006840 Mg2+ binding site [ion binding]; other site 324057006841 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 324057006842 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 324057006843 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 324057006844 active site 324057006845 catalytic motif [active] 324057006846 Zn binding site [ion binding]; other site 324057006847 GTPase Era; Reviewed; Region: era; PRK00089 324057006848 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 324057006849 G1 box; other site 324057006850 GTP/Mg2+ binding site [chemical binding]; other site 324057006851 Switch I region; other site 324057006852 G2 box; other site 324057006853 Switch II region; other site 324057006854 G3 box; other site 324057006855 G4 box; other site 324057006856 G5 box; other site 324057006857 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 324057006858 YqzL-like protein; Region: YqzL; pfam14006 324057006859 Recombination protein O N terminal; Region: RecO_N; cl15812 324057006860 DNA repair protein RecO; Region: reco; TIGR00613 324057006861 Recombination protein O C terminal; Region: RecO_C; pfam02565 324057006862 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 324057006863 dimer interface [polypeptide binding]; other site 324057006864 motif 1; other site 324057006865 active site 324057006866 motif 2; other site 324057006867 motif 3; other site 324057006868 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 324057006869 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 324057006870 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 324057006871 DNA primase; Validated; Region: dnaG; PRK05667 324057006872 CHC2 zinc finger; Region: zf-CHC2; cl15369 324057006873 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 324057006874 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 324057006875 active site 324057006876 metal binding site [ion binding]; metal-binding site 324057006877 interdomain interaction site; other site 324057006878 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 324057006879 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 324057006880 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 324057006881 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324057006882 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057006883 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057006884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057006885 DNA binding residues [nucleotide binding] 324057006886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057006887 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 324057006888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 324057006889 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 324057006890 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 324057006891 active site 324057006892 catalytic triad [active] 324057006893 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 324057006894 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 324057006895 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057006896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006897 Walker A/P-loop; other site 324057006898 ATP binding site [chemical binding]; other site 324057006899 Q-loop/lid; other site 324057006900 ABC transporter signature motif; other site 324057006901 Walker B; other site 324057006902 D-loop; other site 324057006903 H-loop/switch region; other site 324057006904 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324057006905 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 324057006906 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 324057006907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057006908 Family description; Region: UvrD_C_2; cl15862 324057006909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057006910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057006911 glycogen branching enzyme; Provisional; Region: PRK12313 324057006912 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 324057006913 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 324057006914 active site 324057006915 catalytic site [active] 324057006916 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 324057006917 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 324057006918 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324057006919 ligand binding site; other site 324057006920 oligomer interface; other site 324057006921 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324057006922 dimer interface [polypeptide binding]; other site 324057006923 N-terminal domain interface [polypeptide binding]; other site 324057006924 sulfate 1 binding site; other site 324057006925 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 324057006926 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324057006927 ligand binding site; other site 324057006928 oligomer interface; other site 324057006929 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324057006930 dimer interface [polypeptide binding]; other site 324057006931 N-terminal domain interface [polypeptide binding]; other site 324057006932 sulfate 1 binding site; other site 324057006933 glycogen synthase; Provisional; Region: glgA; PRK00654 324057006934 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 324057006935 ADP-binding pocket [chemical binding]; other site 324057006936 homodimer interface [polypeptide binding]; other site 324057006937 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 324057006938 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 324057006939 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 324057006940 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 324057006941 Spore germination protein GerPC; Region: GerPC; pfam10737 324057006942 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 324057006943 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 324057006944 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 324057006945 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057006946 metal binding site 2 [ion binding]; metal-binding site 324057006947 putative DNA binding helix; other site 324057006948 metal binding site 1 [ion binding]; metal-binding site 324057006949 dimer interface [polypeptide binding]; other site 324057006950 structural Zn2+ binding site [ion binding]; other site 324057006951 Haemolytic domain; Region: Haemolytic; cl00506 324057006952 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 324057006953 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 324057006954 active site 324057006955 HIGH motif; other site 324057006956 KMSKS motif; other site 324057006957 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 324057006958 tRNA binding surface [nucleotide binding]; other site 324057006959 anticodon binding site; other site 324057006960 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 324057006961 dimer interface [polypeptide binding]; other site 324057006962 putative tRNA-binding site [nucleotide binding]; other site 324057006963 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 324057006964 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 324057006965 metal binding site [ion binding]; metal-binding site 324057006966 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057006967 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 324057006968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057006969 ABC-ATPase subunit interface; other site 324057006970 dimer interface [polypeptide binding]; other site 324057006971 putative PBP binding regions; other site 324057006972 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 324057006973 manganese transport transcriptional regulator; Provisional; Region: PRK03902 324057006974 Helix-turn-helix domains; Region: HTH; cl00088 324057006975 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 324057006976 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 324057006977 ligand binding site [chemical binding]; other site 324057006978 active site 324057006979 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 324057006980 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 324057006981 active site 324057006982 nucleophile elbow; other site 324057006983 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 324057006984 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 324057006985 Conserved membrane protein YqhR; Region: YqhR; pfam11085 324057006986 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 324057006987 trimer interface [polypeptide binding]; other site 324057006988 active site 324057006989 dimer interface [polypeptide binding]; other site 324057006990 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324057006991 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324057006992 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324057006993 active site 324057006994 elongation factor P; Validated; Region: PRK00529 324057006995 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 324057006996 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 324057006997 RNA binding site [nucleotide binding]; other site 324057006998 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 324057006999 RNA binding site [nucleotide binding]; other site 324057007000 aspartate kinase; Reviewed; Region: PRK06635 324057007001 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 324057007002 putative nucleotide binding site [chemical binding]; other site 324057007003 putative catalytic residues [active] 324057007004 putative Mg ion binding site [ion binding]; other site 324057007005 putative aspartate binding site [chemical binding]; other site 324057007006 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 324057007007 putative allosteric regulatory site; other site 324057007008 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 324057007009 Protein of unknown function (DUF441); Region: DUF441; cl01041 324057007010 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 324057007011 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 324057007012 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 324057007013 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 324057007014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007015 Walker A motif; other site 324057007016 ATP binding site [chemical binding]; other site 324057007017 Walker B motif; other site 324057007018 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 324057007019 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 324057007020 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 324057007021 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 324057007022 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 324057007023 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 324057007024 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 324057007025 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 324057007026 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 324057007027 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324057007028 carboxyltransferase (CT) interaction site; other site 324057007029 biotinylation site [posttranslational modification]; other site 324057007030 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 324057007031 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057007032 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 324057007033 Asp23 family; Region: Asp23; cl00574 324057007034 Asp23 family; Region: Asp23; cl00574 324057007035 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 324057007036 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 324057007037 putative RNA binding site [nucleotide binding]; other site 324057007038 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 324057007039 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 324057007040 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 324057007041 homodimer interface [polypeptide binding]; other site 324057007042 NADP binding site [chemical binding]; other site 324057007043 substrate binding site [chemical binding]; other site 324057007044 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 324057007045 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 324057007046 generic binding surface II; other site 324057007047 generic binding surface I; other site 324057007048 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 324057007049 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324057007050 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324057007051 substrate binding pocket [chemical binding]; other site 324057007052 chain length determination region; other site 324057007053 substrate-Mg2+ binding site; other site 324057007054 catalytic residues [active] 324057007055 aspartate-rich region 1; other site 324057007056 active site lid residues [active] 324057007057 aspartate-rich region 2; other site 324057007058 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 324057007059 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 324057007060 TPP-binding site; other site 324057007061 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324057007062 PYR/PP interface [polypeptide binding]; other site 324057007063 dimer interface [polypeptide binding]; other site 324057007064 TPP binding site [chemical binding]; other site 324057007065 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057007066 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 324057007067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057007068 RNA binding surface [nucleotide binding]; other site 324057007069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057007070 arginine repressor; Provisional; Region: PRK04280 324057007071 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 324057007072 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 324057007073 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 324057007074 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 324057007075 Walker A/P-loop; other site 324057007076 ATP binding site [chemical binding]; other site 324057007077 Q-loop/lid; other site 324057007078 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 324057007079 Q-loop/lid; other site 324057007080 ABC transporter signature motif; other site 324057007081 Walker B; other site 324057007082 D-loop; other site 324057007083 H-loop/switch region; other site 324057007084 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 324057007085 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 324057007086 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 324057007087 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 324057007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007089 active site 324057007090 phosphorylation site [posttranslational modification] 324057007091 intermolecular recognition site; other site 324057007092 dimerization interface [polypeptide binding]; other site 324057007093 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 324057007094 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 324057007095 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 324057007096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057007098 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057007099 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 324057007100 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324057007101 tetramer interface [polypeptide binding]; other site 324057007102 TPP-binding site [chemical binding]; other site 324057007103 heterodimer interface [polypeptide binding]; other site 324057007104 phosphorylation loop region [posttranslational modification] 324057007105 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324057007106 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324057007107 alpha subunit interface [polypeptide binding]; other site 324057007108 TPP binding site [chemical binding]; other site 324057007109 heterodimer interface [polypeptide binding]; other site 324057007110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057007111 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324057007112 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 324057007113 peptidase T-like protein; Region: PepT-like; TIGR01883 324057007114 metal binding site [ion binding]; metal-binding site 324057007115 putative dimer interface [polypeptide binding]; other site 324057007116 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 324057007117 dimer interface [polypeptide binding]; other site 324057007118 ADP-ribose binding site [chemical binding]; other site 324057007119 active site 324057007120 nudix motif; other site 324057007121 metal binding site [ion binding]; metal-binding site 324057007122 Integral membrane protein DUF95; Region: DUF95; cl00572 324057007123 ferric uptake regulator; Provisional; Region: fur; PRK09462 324057007124 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057007125 metal binding site 2 [ion binding]; metal-binding site 324057007126 putative DNA binding helix; other site 324057007127 metal binding site 1 [ion binding]; metal-binding site 324057007128 dimer interface [polypeptide binding]; other site 324057007129 structural Zn2+ binding site [ion binding]; other site 324057007130 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 324057007131 active site 324057007132 catalytic residues [active] 324057007133 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 324057007134 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 324057007135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007136 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 324057007137 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 324057007138 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 324057007139 active site 324057007140 Int/Topo IB signature motif; other site 324057007141 Sulfatase; Region: Sulfatase; cl10460 324057007142 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 324057007143 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 324057007144 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 324057007145 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 324057007146 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324057007147 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324057007148 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 324057007149 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324057007150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057007151 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 324057007152 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324057007153 anti sigma factor interaction site; other site 324057007154 regulatory phosphorylation site [posttranslational modification]; other site 324057007155 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 324057007156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007157 ATP binding site [chemical binding]; other site 324057007158 Mg2+ binding site [ion binding]; other site 324057007159 G-X-G motif; other site 324057007160 sporulation sigma factor SigF; Validated; Region: PRK05572 324057007161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057007162 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057007163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057007164 DNA binding residues [nucleotide binding] 324057007165 topology modulation protein; Provisional; Region: PRK07261 324057007166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007167 topology modulation protein; Reviewed; Region: PRK08118 324057007168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007169 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 324057007170 CCGSCS motif protein; Region: CCGSCS; TIGR04101 324057007171 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 324057007172 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057007173 diaminopimelate decarboxylase; Region: lysA; TIGR01048 324057007174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 324057007175 active site 324057007176 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057007177 substrate binding site [chemical binding]; other site 324057007178 catalytic residues [active] 324057007179 dimer interface [polypeptide binding]; other site 324057007180 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324057007181 active site 324057007182 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 324057007183 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 324057007184 catalytic motif [active] 324057007185 Zn binding site [ion binding]; other site 324057007186 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 324057007187 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 324057007188 Lumazine binding domain; Region: Lum_binding; pfam00677 324057007189 Lumazine binding domain; Region: Lum_binding; pfam00677 324057007190 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 324057007191 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 324057007192 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324057007193 dimerization interface [polypeptide binding]; other site 324057007194 active site 324057007195 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 324057007196 homopentamer interface [polypeptide binding]; other site 324057007197 active site 324057007198 ScpA/B protein; Region: ScpA_ScpB; cl00598 324057007199 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 324057007200 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 324057007201 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 324057007202 Walker A/P-loop; other site 324057007203 ATP binding site [chemical binding]; other site 324057007204 Q-loop/lid; other site 324057007205 ABC transporter signature motif; other site 324057007206 Walker B; other site 324057007207 D-loop; other site 324057007208 H-loop/switch region; other site 324057007209 NIL domain; Region: NIL; cl09633 324057007210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007211 dimer interface [polypeptide binding]; other site 324057007212 conserved gate region; other site 324057007213 ABC-ATPase subunit interface; other site 324057007214 NMT1-like family; Region: NMT1_2; cl15260 324057007215 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 324057007216 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 324057007217 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324057007218 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057007219 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 324057007220 Nucleoside recognition; Region: Gate; cl00486 324057007221 Nucleoside recognition; Region: Gate; cl00486 324057007222 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324057007223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057007224 RNA binding surface [nucleotide binding]; other site 324057007225 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 324057007226 active site 324057007227 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324057007228 catalytic residues [active] 324057007229 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 324057007230 ResB-like family; Region: ResB; pfam05140 324057007231 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324057007232 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324057007233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057007234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007235 active site 324057007236 phosphorylation site [posttranslational modification] 324057007237 intermolecular recognition site; other site 324057007238 dimerization interface [polypeptide binding]; other site 324057007239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057007240 DNA binding site [nucleotide binding] 324057007241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057007242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057007243 dimerization interface [polypeptide binding]; other site 324057007244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057007245 dimer interface [polypeptide binding]; other site 324057007246 phosphorylation site [posttranslational modification] 324057007247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007248 ATP binding site [chemical binding]; other site 324057007249 Mg2+ binding site [ion binding]; other site 324057007250 G-X-G motif; other site 324057007251 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 324057007252 arsenical pump membrane protein; Provisional; Region: PRK15445 324057007253 transmembrane helices; other site 324057007254 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 324057007255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007256 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 324057007257 putative L-serine binding site [chemical binding]; other site 324057007258 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 324057007259 active site residue [active] 324057007260 CAAX protease self-immunity; Region: Abi; cl00558 324057007261 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057007262 NodB motif; other site 324057007263 active site 324057007264 catalytic site [active] 324057007265 metal binding site [ion binding]; metal-binding site 324057007266 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 324057007267 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 324057007268 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 324057007269 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 324057007270 NAD(P) binding site [chemical binding]; other site 324057007271 Protease prsW family; Region: PrsW-protease; cl15823 324057007272 germination protein YpeB; Region: spore_YpeB; TIGR02889 324057007273 Flagellar protein YcgR; Region: YcgR_2; pfam12945 324057007274 PilZ domain; Region: PilZ; cl01260 324057007275 cytidylate kinase; Provisional; Region: cmk; PRK00023 324057007276 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 324057007277 CMP-binding site; other site 324057007278 The sites determining sugar specificity; other site 324057007279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324057007280 putative acyl-acceptor binding pocket; other site 324057007281 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 324057007282 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 324057007283 RNA binding site [nucleotide binding]; other site 324057007284 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 324057007285 RNA binding site [nucleotide binding]; other site 324057007286 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 324057007287 RNA binding site [nucleotide binding]; other site 324057007288 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 324057007289 RNA binding site [nucleotide binding]; other site 324057007290 YIEGIA protein; Region: YIEGIA; pfam14045 324057007291 GTP-binding protein Der; Reviewed; Region: PRK00093 324057007292 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 324057007293 G1 box; other site 324057007294 GTP/Mg2+ binding site [chemical binding]; other site 324057007295 Switch I region; other site 324057007296 G2 box; other site 324057007297 Switch II region; other site 324057007298 G3 box; other site 324057007299 G4 box; other site 324057007300 G5 box; other site 324057007301 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 324057007302 G1 box; other site 324057007303 GTP/Mg2+ binding site [chemical binding]; other site 324057007304 Switch I region; other site 324057007305 G2 box; other site 324057007306 G3 box; other site 324057007307 Switch II region; other site 324057007308 G4 box; other site 324057007309 G5 box; other site 324057007310 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 324057007311 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 324057007312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007313 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 324057007314 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 324057007315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324057007316 catalytic loop [active] 324057007317 iron binding site [ion binding]; other site 324057007318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 324057007319 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 324057007320 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 324057007321 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 324057007322 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057007323 putative ligand binding site [chemical binding]; other site 324057007324 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057007325 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057007326 Walker A/P-loop; other site 324057007327 ATP binding site [chemical binding]; other site 324057007328 Q-loop/lid; other site 324057007329 ABC transporter signature motif; other site 324057007330 Walker B; other site 324057007331 D-loop; other site 324057007332 H-loop/switch region; other site 324057007333 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057007334 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057007335 TM-ABC transporter signature motif; other site 324057007336 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 324057007337 IHF dimer interface [polypeptide binding]; other site 324057007338 IHF - DNA interface [nucleotide binding]; other site 324057007339 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 324057007340 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 324057007341 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 324057007342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007343 S-adenosylmethionine binding site [chemical binding]; other site 324057007344 UbiA prenyltransferase family; Region: UbiA; cl00337 324057007345 aromatic acid decarboxylase; Validated; Region: PRK05920 324057007346 Flavoprotein; Region: Flavoprotein; cl08021 324057007347 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 324057007348 NMT1-like family; Region: NMT1_2; cl15260 324057007349 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324057007350 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324057007351 substrate binding pocket [chemical binding]; other site 324057007352 chain length determination region; other site 324057007353 substrate-Mg2+ binding site; other site 324057007354 catalytic residues [active] 324057007355 aspartate-rich region 1; other site 324057007356 active site lid residues [active] 324057007357 aspartate-rich region 2; other site 324057007358 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324057007359 active site 324057007360 multimer interface [polypeptide binding]; other site 324057007361 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 324057007362 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 324057007363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007364 S-adenosylmethionine binding site [chemical binding]; other site 324057007365 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 324057007366 active site 324057007367 dimer interface [polypeptide binding]; other site 324057007368 metal binding site [ion binding]; metal-binding site 324057007369 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 324057007370 homotrimer interaction site [polypeptide binding]; other site 324057007371 active site 324057007372 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 324057007373 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 324057007374 chorismate binding enzyme; Region: Chorismate_bind; cl10555 324057007375 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 324057007376 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324057007377 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324057007378 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 324057007379 active site 324057007380 ribulose/triose binding site [chemical binding]; other site 324057007381 phosphate binding site [ion binding]; other site 324057007382 substrate (anthranilate) binding pocket [chemical binding]; other site 324057007383 product (indole) binding pocket [chemical binding]; other site 324057007384 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 324057007385 active site 324057007386 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 324057007387 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 324057007388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007389 catalytic residue [active] 324057007390 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 324057007391 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 324057007392 substrate binding site [chemical binding]; other site 324057007393 active site 324057007394 catalytic residues [active] 324057007395 heterodimer interface [polypeptide binding]; other site 324057007396 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 324057007397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057007398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007399 homodimer interface [polypeptide binding]; other site 324057007400 catalytic residue [active] 324057007401 prephenate dehydrogenase; Validated; Region: PRK06545 324057007402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007403 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 324057007404 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 324057007405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057007406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057007407 DNA binding residues [nucleotide binding] 324057007408 Putative zinc-finger; Region: zf-HC2; cl15806 324057007409 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057007410 catalytic core [active] 324057007411 IDEAL domain; Region: IDEAL; cl07452 324057007412 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 324057007413 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 324057007414 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 324057007415 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 324057007416 iron-sulfur cluster [ion binding]; other site 324057007417 [2Fe-2S] cluster binding site [ion binding]; other site 324057007418 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 324057007419 interchain domain interface [polypeptide binding]; other site 324057007420 intrachain domain interface; other site 324057007421 heme bH binding site [chemical binding]; other site 324057007422 Qi binding site; other site 324057007423 heme bL binding site [chemical binding]; other site 324057007424 Qo binding site; other site 324057007425 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 324057007426 interchain domain interface [polypeptide binding]; other site 324057007427 intrachain domain interface; other site 324057007428 Qi binding site; other site 324057007429 Qo binding site; other site 324057007430 Cytochrome c; Region: Cytochrom_C; cl11414 324057007431 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 324057007432 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 324057007433 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057007434 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057007435 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057007436 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 324057007437 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 324057007438 homodimer interface [polypeptide binding]; other site 324057007439 metal binding site [ion binding]; metal-binding site 324057007440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057007441 binding surface 324057007442 TPR motif; other site 324057007443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057007444 TPR motif; other site 324057007445 binding surface 324057007446 dihydrodipicolinate reductase; Provisional; Region: PRK00048 324057007447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007448 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 324057007449 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 324057007450 active site 324057007451 dimer interfaces [polypeptide binding]; other site 324057007452 catalytic residues [active] 324057007453 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324057007454 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 324057007455 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 324057007456 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 324057007457 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 324057007458 active site 324057007459 NTP binding site [chemical binding]; other site 324057007460 metal binding triad [ion binding]; metal-binding site 324057007461 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 324057007462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057007463 Helix-turn-helix domains; Region: HTH; cl00088 324057007464 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 324057007465 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324057007466 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 324057007467 oligomerization interface [polypeptide binding]; other site 324057007468 active site 324057007469 metal binding site [ion binding]; metal-binding site 324057007470 Pantoate-beta-alanine ligase; Region: PanC; cd00560 324057007471 pantoate--beta-alanine ligase; Region: panC; TIGR00018 324057007472 active site 324057007473 ATP-binding site [chemical binding]; other site 324057007474 pantoate-binding site; other site 324057007475 HXXH motif; other site 324057007476 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 324057007477 tetramerization interface [polypeptide binding]; other site 324057007478 active site 324057007479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057007480 binding surface 324057007481 TPR motif; other site 324057007482 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057007483 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 324057007484 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324057007485 active site 324057007486 catalytic site [active] 324057007487 substrate binding site [chemical binding]; other site 324057007488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007490 putative Mg++ binding site [ion binding]; other site 324057007491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007492 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 324057007493 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 324057007494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007495 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 324057007496 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 324057007497 active site 324057007498 putative substrate binding pocket [chemical binding]; other site 324057007499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 324057007500 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057007501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057007502 Walker A motif; other site 324057007503 ATP binding site [chemical binding]; other site 324057007504 Walker B motif; other site 324057007505 arginine finger; other site 324057007506 Peptidase family M41; Region: Peptidase_M41; pfam01434 324057007507 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 324057007508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007509 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057007510 Acetokinase family; Region: Acetate_kinase; cl01029 324057007511 acetate kinase; Region: ackA; TIGR00016 324057007512 Helix-turn-helix domains; Region: HTH; cl00088 324057007513 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 324057007514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057007516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057007518 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057007519 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 324057007520 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057007521 DinB superfamily; Region: DinB_2; pfam12867 324057007522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057007523 active site 324057007524 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057007525 intersubunit interface [polypeptide binding]; other site 324057007526 active site 324057007527 Zn2+ binding site [ion binding]; other site 324057007528 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057007529 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 324057007530 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 324057007531 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 324057007532 dimer interface [polypeptide binding]; other site 324057007533 active site 324057007534 catalytic residue [active] 324057007535 metal binding site [ion binding]; metal-binding site 324057007536 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 324057007537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007538 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 324057007539 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 324057007540 putative catalytic cysteine [active] 324057007541 gamma-glutamyl kinase; Provisional; Region: PRK05429 324057007542 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 324057007543 nucleotide binding site [chemical binding]; other site 324057007544 homotetrameric interface [polypeptide binding]; other site 324057007545 putative phosphate binding site [ion binding]; other site 324057007546 putative allosteric binding site; other site 324057007547 PUA domain; Region: PUA; cl00607 324057007548 transaminase; Reviewed; Region: PRK08068 324057007549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057007550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007551 homodimer interface [polypeptide binding]; other site 324057007552 catalytic residue [active] 324057007553 Predicted amidohydrolase [General function prediction only]; Region: COG0388 324057007554 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 324057007555 putative active site [active] 324057007556 catalytic triad [active] 324057007557 putative dimer interface [polypeptide binding]; other site 324057007558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057007559 Helix-turn-helix domains; Region: HTH; cl00088 324057007560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057007561 dimerization interface [polypeptide binding]; other site 324057007562 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 324057007563 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 324057007564 substrate binding site [chemical binding]; other site 324057007565 ligand binding site [chemical binding]; other site 324057007566 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 324057007567 substrate binding site [chemical binding]; other site 324057007568 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057007569 AMIN domain; Region: AMIN; pfam11741 324057007570 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057007571 active site 324057007572 metal binding site [ion binding]; metal-binding site 324057007573 Sporulation and spore germination; Region: Germane; cl11253 324057007574 S-layer homology domain; Region: SLH; pfam00395 324057007575 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 324057007576 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324057007577 minor groove reading motif; other site 324057007578 helix-hairpin-helix signature motif; other site 324057007579 substrate binding pocket [chemical binding]; other site 324057007580 active site 324057007581 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 324057007582 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324057007583 Dynamin family; Region: Dynamin_N; pfam00350 324057007584 G1 box; other site 324057007585 GTP/Mg2+ binding site [chemical binding]; other site 324057007586 G2 box; other site 324057007587 Switch I region; other site 324057007588 G3 box; other site 324057007589 Switch II region; other site 324057007590 G4 box; other site 324057007591 G5 box; other site 324057007592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007593 Dynamin family; Region: Dynamin_N; pfam00350 324057007594 G1 box; other site 324057007595 GTP/Mg2+ binding site [chemical binding]; other site 324057007596 G2 box; other site 324057007597 Switch I region; other site 324057007598 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324057007599 G3 box; other site 324057007600 Switch II region; other site 324057007601 GTP/Mg2+ binding site [chemical binding]; other site 324057007602 G4 box; other site 324057007603 G5 box; other site 324057007604 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057007605 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057007606 metal binding site [ion binding]; metal-binding site 324057007607 active site 324057007608 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057007609 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057007610 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057007611 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057007612 H+ Antiporter protein; Region: 2A0121; TIGR00900 324057007613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057007614 Helix-turn-helix domains; Region: HTH; cl00088 324057007615 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057007616 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324057007617 NAD(P) binding site [chemical binding]; other site 324057007618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057007619 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057007620 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057007621 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057007622 Walker A/P-loop; other site 324057007623 ATP binding site [chemical binding]; other site 324057007624 Q-loop/lid; other site 324057007625 ABC transporter signature motif; other site 324057007626 Walker B; other site 324057007627 D-loop; other site 324057007628 H-loop/switch region; other site 324057007629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057007630 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057007631 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 324057007632 Walker A/P-loop; other site 324057007633 ATP binding site [chemical binding]; other site 324057007634 Q-loop/lid; other site 324057007635 ABC transporter signature motif; other site 324057007636 Walker B; other site 324057007637 D-loop; other site 324057007638 H-loop/switch region; other site 324057007639 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 324057007640 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057007641 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 324057007642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007643 Mg2+ binding site [ion binding]; other site 324057007644 G-X-G motif; other site 324057007645 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324057007646 anchoring element; other site 324057007647 dimer interface [polypeptide binding]; other site 324057007648 ATP binding site [chemical binding]; other site 324057007649 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324057007650 active site 324057007651 putative metal-binding site [ion binding]; other site 324057007652 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324057007653 DNA gyrase subunit A; Validated; Region: PRK05560 324057007654 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 324057007655 CAP-like domain; other site 324057007656 active site 324057007657 primary dimer interface [polypeptide binding]; other site 324057007658 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057007659 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057007660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057007661 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057007662 Helix-turn-helix domains; Region: HTH; cl00088 324057007663 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057007664 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057007665 putative active site [active] 324057007666 putative metal binding site [ion binding]; other site 324057007667 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057007668 active site 324057007669 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 324057007670 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324057007671 active site 324057007672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057007673 sequence-specific DNA binding site [nucleotide binding]; other site 324057007674 salt bridge; other site 324057007675 L-arabinose isomerase; Provisional; Region: PRK02929 324057007676 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 324057007677 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 324057007678 trimer interface [polypeptide binding]; other site 324057007679 putative substrate binding site [chemical binding]; other site 324057007680 putative metal binding site [ion binding]; other site 324057007681 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 324057007682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057007683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057007684 putative substrate translocation pore; other site 324057007685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057007686 Helix-turn-helix domains; Region: HTH; cl00088 324057007687 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 324057007688 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 324057007689 NodB motif; other site 324057007690 active site 324057007691 catalytic site [active] 324057007692 Cd binding site [ion binding]; other site 324057007693 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 324057007694 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 324057007695 homodimer interface [polypeptide binding]; other site 324057007696 substrate-cofactor binding pocket; other site 324057007697 catalytic residue [active] 324057007698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057007699 Helix-turn-helix domains; Region: HTH; cl00088 324057007700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057007701 dimerization interface [polypeptide binding]; other site 324057007702 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324057007703 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324057007704 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324057007705 Cache domain; Region: Cache_1; pfam02743 324057007706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057007707 dimerization interface [polypeptide binding]; other site 324057007708 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057007709 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057007710 dimer interface [polypeptide binding]; other site 324057007711 putative CheW interface [polypeptide binding]; other site 324057007712 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057007713 dimer interface [polypeptide binding]; other site 324057007714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057007715 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057007716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057007717 Coenzyme A binding pocket [chemical binding]; other site 324057007718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057007719 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057007720 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 324057007721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057007722 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057007723 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 324057007724 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057007725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007726 S-adenosylmethionine binding site [chemical binding]; other site 324057007727 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 324057007728 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057007729 active site 324057007730 metal binding site [ion binding]; metal-binding site 324057007731 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 324057007732 active site 324057007733 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 324057007734 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057007735 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057007736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057007737 motif II; other site 324057007738 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057007739 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057007740 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057007741 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057007742 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057007743 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057007744 metal binding site [ion binding]; metal-binding site 324057007745 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057007746 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057007747 active site 324057007748 metal binding site [ion binding]; metal-binding site 324057007749 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 324057007750 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057007751 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057007752 active site 324057007753 catalytic triad [active] 324057007754 oxyanion hole [active] 324057007755 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 324057007756 putative active site [active] 324057007757 YdjC motif; other site 324057007758 Mg binding site [ion binding]; other site 324057007759 homodimer interface [polypeptide binding]; other site 324057007760 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 324057007761 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 324057007762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057007763 Histidine kinase; Region: His_kinase; pfam06580 324057007764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007765 ATP binding site [chemical binding]; other site 324057007766 Mg2+ binding site [ion binding]; other site 324057007767 G-X-G motif; other site 324057007768 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057007769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007770 active site 324057007771 phosphorylation site [posttranslational modification] 324057007772 intermolecular recognition site; other site 324057007773 dimerization interface [polypeptide binding]; other site 324057007774 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057007775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007776 dimer interface [polypeptide binding]; other site 324057007777 conserved gate region; other site 324057007778 putative PBP binding loops; other site 324057007779 ABC-ATPase subunit interface; other site 324057007780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057007781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007782 dimer interface [polypeptide binding]; other site 324057007783 conserved gate region; other site 324057007784 putative PBP binding loops; other site 324057007785 ABC-ATPase subunit interface; other site 324057007786 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057007787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007788 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057007789 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057007790 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 324057007791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057007792 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 324057007793 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057007794 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057007795 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057007796 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057007797 Interdomain contacts; other site 324057007798 Cytokine receptor motif; other site 324057007799 S-layer homology domain; Region: SLH; pfam00395 324057007800 S-layer homology domain; Region: SLH; pfam00395 324057007801 S-layer homology domain; Region: SLH; pfam00395 324057007802 PA14 domain; Region: PA14; cl08459 324057007803 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057007804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007805 active site 324057007806 phosphorylation site [posttranslational modification] 324057007807 intermolecular recognition site; other site 324057007808 dimerization interface [polypeptide binding]; other site 324057007809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007810 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 324057007811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057007812 dimerization interface [polypeptide binding]; other site 324057007813 Histidine kinase; Region: His_kinase; pfam06580 324057007814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007815 ATP binding site [chemical binding]; other site 324057007816 Mg2+ binding site [ion binding]; other site 324057007817 G-X-G motif; other site 324057007818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057007819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057007820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057007821 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057007822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007823 dimer interface [polypeptide binding]; other site 324057007824 conserved gate region; other site 324057007825 putative PBP binding loops; other site 324057007826 ABC-ATPase subunit interface; other site 324057007827 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 324057007828 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 324057007829 putative sugar binding sites [chemical binding]; other site 324057007830 Q-X-W motif; other site 324057007831 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057007832 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057007833 active site 324057007834 catalytic tetrad [active] 324057007835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057007836 Helix-turn-helix domains; Region: HTH; cl00088 324057007837 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057007838 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057007839 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057007840 active site 324057007841 catalytic triad [active] 324057007842 oxyanion hole [active] 324057007843 Cupin domain; Region: Cupin_2; cl09118 324057007844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057007845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007846 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057007847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007848 active site 324057007849 phosphorylation site [posttranslational modification] 324057007850 intermolecular recognition site; other site 324057007851 dimerization interface [polypeptide binding]; other site 324057007852 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057007853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057007855 dimerization interface [polypeptide binding]; other site 324057007856 Histidine kinase; Region: His_kinase; pfam06580 324057007857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007858 ATP binding site [chemical binding]; other site 324057007859 Mg2+ binding site [ion binding]; other site 324057007860 G-X-G motif; other site 324057007861 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057007862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057007863 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057007864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007865 putative PBP binding loops; other site 324057007866 ABC-ATPase subunit interface; other site 324057007867 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057007868 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057007869 VPS10 domain; Region: VPS10; smart00602 324057007870 PA14 domain; Region: PA14; cl08459 324057007871 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057007872 dockerin binding interface; other site 324057007873 S-layer homology domain; Region: SLH; pfam00395 324057007874 S-layer homology domain; Region: SLH; pfam00395 324057007875 alpha-glucosidase; Provisional; Region: PRK10137 324057007876 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057007877 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 324057007878 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057007879 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 324057007880 active site 324057007881 metal binding site [ion binding]; metal-binding site 324057007882 homodimer interface [polypeptide binding]; other site 324057007883 catalytic site [active] 324057007884 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057007885 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104 324057007886 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 324057007887 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057007888 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057007889 sugar binding site [chemical binding]; other site 324057007890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057007891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007892 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057007893 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057007894 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057007895 AP (apurinic/apyrimidinic) site pocket; other site 324057007896 DNA interaction; other site 324057007897 Metal-binding active site; metal-binding site 324057007898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057007899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007900 active site 324057007901 phosphorylation site [posttranslational modification] 324057007902 intermolecular recognition site; other site 324057007903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057007905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057007907 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057007908 dimerization interface [polypeptide binding]; other site 324057007909 Histidine kinase; Region: His_kinase; pfam06580 324057007910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057007911 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057007912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007913 dimer interface [polypeptide binding]; other site 324057007914 conserved gate region; other site 324057007915 putative PBP binding loops; other site 324057007916 ABC-ATPase subunit interface; other site 324057007917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057007918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007919 dimer interface [polypeptide binding]; other site 324057007920 conserved gate region; other site 324057007921 putative PBP binding loops; other site 324057007922 ABC-ATPase subunit interface; other site 324057007923 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 324057007924 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057007925 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057007926 Ca binding site [ion binding]; other site 324057007927 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 324057007928 active site 324057007929 catalytic site [active] 324057007930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057007931 Cupin domain; Region: Cupin_2; cl09118 324057007932 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057007933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007934 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057007935 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 324057007936 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057007937 active site 324057007938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007939 S-adenosylmethionine binding site [chemical binding]; other site 324057007940 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 324057007941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057007942 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057007943 hydrophobic ligand binding site; other site 324057007944 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324057007945 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324057007946 dimer interface [polypeptide binding]; other site 324057007947 active site 324057007948 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057007949 active site 324057007950 metal binding site [ion binding]; metal-binding site 324057007951 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 324057007952 B12 binding site [chemical binding]; other site 324057007953 cobalt ligand [ion binding]; other site 324057007954 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 324057007955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057007956 Predicted P-loop ATPase/GTPase [General function prediction only]; Region: COG4028 324057007957 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 324057007958 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 324057007959 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 324057007960 Domain of unknown function (DUF309); Region: DUF309; cl00667 324057007961 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 324057007962 active site clefts [active] 324057007963 zinc binding site [ion binding]; other site 324057007964 dimer interface [polypeptide binding]; other site 324057007965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 324057007966 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 324057007967 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 324057007968 active site 324057007969 Zn binding site [ion binding]; other site 324057007970 NMT1-like family; Region: NMT1_2; cl15260 324057007971 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057007972 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057007973 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057007974 Walker A/P-loop; other site 324057007975 ATP binding site [chemical binding]; other site 324057007976 Q-loop/lid; other site 324057007977 ABC transporter signature motif; other site 324057007978 Walker B; other site 324057007979 D-loop; other site 324057007980 H-loop/switch region; other site 324057007981 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057007982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007983 dimer interface [polypeptide binding]; other site 324057007984 conserved gate region; other site 324057007985 putative PBP binding loops; other site 324057007986 ABC-ATPase subunit interface; other site 324057007987 Predicted membrane protein [Function unknown]; Region: COG4129 324057007988 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 324057007989 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 324057007990 Outer spore coat protein E (CotE); Region: CotE; pfam10628 324057007991 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 324057007992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 324057007993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057007994 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 324057007995 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057007996 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 324057007997 MutS domain I; Region: MutS_I; pfam01624 324057007998 MutS domain II; Region: MutS_II; pfam05188 324057007999 MutS family domain IV; Region: MutS_IV; pfam05190 324057008000 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008001 Walker A/P-loop; other site 324057008002 ATP binding site [chemical binding]; other site 324057008003 Q-loop/lid; other site 324057008004 ABC transporter signature motif; other site 324057008005 Walker B; other site 324057008006 D-loop; other site 324057008007 H-loop/switch region; other site 324057008008 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 324057008009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008010 ATP binding site [chemical binding]; other site 324057008011 Mg2+ binding site [ion binding]; other site 324057008012 G-X-G motif; other site 324057008013 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 324057008014 ATP binding site [chemical binding]; other site 324057008015 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 324057008016 Brix domain; Region: Brix; cl00935 324057008017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057008018 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 324057008019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008020 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 324057008021 Sm1 motif; other site 324057008022 intra - hexamer interaction site; other site 324057008023 inter - hexamer interaction site [polypeptide binding]; other site 324057008024 nucleotide binding pocket [chemical binding]; other site 324057008025 Sm2 motif; other site 324057008026 Transglycosylase; Region: Transgly; cl07896 324057008027 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057008028 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057008029 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057008030 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 324057008031 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324057008032 active site 324057008033 Protein of unknown function (DUF402); Region: DUF402; cl00979 324057008034 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 324057008035 putative active site [active] 324057008036 stage V sporulation protein K; Region: spore_V_K; TIGR02881 324057008037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057008038 Walker A motif; other site 324057008039 ATP binding site [chemical binding]; other site 324057008040 Walker B motif; other site 324057008041 arginine finger; other site 324057008042 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 324057008043 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 324057008044 HflX GTPase family; Region: HflX; cd01878 324057008045 G1 box; other site 324057008046 GTP/Mg2+ binding site [chemical binding]; other site 324057008047 Switch I region; other site 324057008048 G2 box; other site 324057008049 G3 box; other site 324057008050 Switch II region; other site 324057008051 G4 box; other site 324057008052 G5 box; other site 324057008053 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 324057008054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057008055 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 324057008056 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057008057 DNA binding residues [nucleotide binding] 324057008058 putative dimer interface [polypeptide binding]; other site 324057008059 glutamine synthetase, type I; Region: GlnA; TIGR00653 324057008060 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324057008061 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324057008062 PspC domain; Region: PspC; cl00864 324057008063 LexA repressor; Validated; Region: PRK00215 324057008064 Helix-turn-helix domains; Region: HTH; cl00088 324057008065 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 324057008066 Catalytic site [active] 324057008067 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057008068 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 324057008069 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 324057008070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008071 motif II; other site 324057008072 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 324057008073 Cupin domain; Region: Cupin_2; cl09118 324057008074 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 324057008075 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 324057008076 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 324057008077 substrate binding pocket [chemical binding]; other site 324057008078 dimer interface [polypeptide binding]; other site 324057008079 inhibitor binding site; inhibition site 324057008080 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 324057008081 B12 binding site [chemical binding]; other site 324057008082 cobalt ligand [ion binding]; other site 324057008083 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 324057008084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057008085 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 324057008086 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 324057008087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057008088 ATP binding site [chemical binding]; other site 324057008089 putative Mg++ binding site [ion binding]; other site 324057008090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057008091 nucleotide binding region [chemical binding]; other site 324057008092 ATP-binding site [chemical binding]; other site 324057008093 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 324057008094 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 324057008095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057008096 binding surface 324057008097 TPR motif; other site 324057008098 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 324057008099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008100 active site 324057008101 motif I; other site 324057008102 motif II; other site 324057008103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008104 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 324057008105 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 324057008106 putative DNA binding site [nucleotide binding]; other site 324057008107 catalytic residue [active] 324057008108 putative H2TH interface [polypeptide binding]; other site 324057008109 putative catalytic residues [active] 324057008110 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 324057008111 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324057008112 AP endonuclease family 2; Region: AP2Ec; smart00518 324057008113 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 324057008114 AP (apurinic/apyrimidinic) site pocket; other site 324057008115 DNA interaction; other site 324057008116 Metal-binding active site; metal-binding site 324057008117 THUMP domain; Region: THUMP; cl12076 324057008118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057008119 Protein kinase domain; Region: Pkinase; pfam00069 324057008120 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324057008121 active site 324057008122 ATP binding site [chemical binding]; other site 324057008123 substrate binding site [chemical binding]; other site 324057008124 activation loop (A-loop); other site 324057008125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057008126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008127 active site 324057008128 phosphorylation site [posttranslational modification] 324057008129 intermolecular recognition site; other site 324057008130 dimerization interface [polypeptide binding]; other site 324057008131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057008132 DNA binding site [nucleotide binding] 324057008133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057008134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057008135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057008136 dimer interface [polypeptide binding]; other site 324057008137 phosphorylation site [posttranslational modification] 324057008138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008139 ATP binding site [chemical binding]; other site 324057008140 Mg2+ binding site [ion binding]; other site 324057008141 G-X-G motif; other site 324057008142 Predicted amidohydrolase [General function prediction only]; Region: COG0388 324057008143 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 324057008144 putative active site [active] 324057008145 catalytic triad [active] 324057008146 putative dimer interface [polypeptide binding]; other site 324057008147 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057008148 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057008149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057008150 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057008151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008152 Walker A/P-loop; other site 324057008153 ATP binding site [chemical binding]; other site 324057008154 Q-loop/lid; other site 324057008155 ABC transporter signature motif; other site 324057008156 Walker B; other site 324057008157 D-loop; other site 324057008158 H-loop/switch region; other site 324057008159 Thiamine pyrophosphokinase; Region: TPK; cd07995 324057008160 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 324057008161 active site 324057008162 dimerization interface [polypeptide binding]; other site 324057008163 thiamine binding site [chemical binding]; other site 324057008164 Predicted membrane protein [Function unknown]; Region: COG2860 324057008165 UPF0126 domain; Region: UPF0126; pfam03458 324057008166 UPF0126 domain; Region: UPF0126; pfam03458 324057008167 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324057008168 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 324057008169 active site 324057008170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057008171 Putative esterase; Region: Esterase; pfam00756 324057008172 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 324057008173 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324057008174 TPP-binding site [chemical binding]; other site 324057008175 tetramer interface [polypeptide binding]; other site 324057008176 heterodimer interface [polypeptide binding]; other site 324057008177 phosphorylation loop region [posttranslational modification] 324057008178 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324057008179 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324057008180 alpha subunit interface [polypeptide binding]; other site 324057008181 TPP binding site [chemical binding]; other site 324057008182 heterodimer interface [polypeptide binding]; other site 324057008183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057008184 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 324057008185 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324057008186 E3 interaction surface; other site 324057008187 lipoyl attachment site [posttranslational modification]; other site 324057008188 e3 binding domain; Region: E3_binding; pfam02817 324057008189 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 324057008190 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 324057008191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057008193 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 324057008194 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057008195 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 324057008196 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 324057008197 dimerization interface [polypeptide binding]; other site 324057008198 active site 324057008199 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 324057008200 folate binding site [chemical binding]; other site 324057008201 NADP+ binding site [chemical binding]; other site 324057008202 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 324057008203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057008204 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 324057008205 DNA topoisomerase III; Provisional; Region: PRK07726 324057008206 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 324057008207 active site 324057008208 putative interdomain interaction site [polypeptide binding]; other site 324057008209 putative metal-binding site [ion binding]; other site 324057008210 putative nucleotide binding site [chemical binding]; other site 324057008211 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324057008212 domain I; other site 324057008213 DNA binding groove [nucleotide binding] 324057008214 phosphate binding site [ion binding]; other site 324057008215 domain II; other site 324057008216 domain III; other site 324057008217 nucleotide binding site [chemical binding]; other site 324057008218 catalytic site [active] 324057008219 domain IV; other site 324057008220 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 324057008221 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 324057008222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008223 motif II; other site 324057008224 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 324057008225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008226 Walker A/P-loop; other site 324057008227 ATP binding site [chemical binding]; other site 324057008228 Q-loop/lid; other site 324057008229 ABC transporter signature motif; other site 324057008230 Walker B; other site 324057008231 D-loop; other site 324057008232 H-loop/switch region; other site 324057008233 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057008234 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057008235 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057008236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 324057008237 MOSC domain; Region: MOSC; pfam03473 324057008238 3-alpha domain; Region: 3-alpha; pfam03475 324057008239 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057008240 Phosphotransferase enzyme family; Region: APH; pfam01636 324057008241 active site 324057008242 substrate binding site [chemical binding]; other site 324057008243 ATP binding site [chemical binding]; other site 324057008244 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 324057008245 putative active site [active] 324057008246 YdjC motif; other site 324057008247 Mg binding site [ion binding]; other site 324057008248 homodimer interface [polypeptide binding]; other site 324057008249 YcxB-like protein; Region: YcxB; pfam14317 324057008250 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057008251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008252 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324057008253 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057008254 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324057008255 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 324057008256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057008258 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008259 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057008260 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057008261 Walker A/P-loop; other site 324057008262 ATP binding site [chemical binding]; other site 324057008263 Q-loop/lid; other site 324057008264 ABC transporter signature motif; other site 324057008265 Walker B; other site 324057008266 D-loop; other site 324057008267 H-loop/switch region; other site 324057008268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008269 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057008270 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057008271 Walker A/P-loop; other site 324057008272 ATP binding site [chemical binding]; other site 324057008273 Q-loop/lid; other site 324057008274 ABC transporter signature motif; other site 324057008275 Walker B; other site 324057008276 D-loop; other site 324057008277 H-loop/switch region; other site 324057008278 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 324057008279 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324057008280 active site 324057008281 DNA binding site [nucleotide binding] 324057008282 Int/Topo IB signature motif; other site 324057008283 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 324057008284 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 324057008285 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057008286 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 324057008287 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057008288 active site 324057008289 dimer interface [polypeptide binding]; other site 324057008290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057008291 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057008292 active site 324057008293 metal binding site [ion binding]; metal-binding site 324057008294 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 324057008295 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 324057008296 S-layer homology domain; Region: SLH; pfam00395 324057008297 S-layer homology domain; Region: SLH; pfam00395 324057008298 S-layer homology domain; Region: SLH; pfam00395 324057008299 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 324057008300 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 324057008301 putative assembly protein; Region: PHA00350 324057008302 Cobalt transport protein; Region: CbiQ; cl00463 324057008303 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 324057008304 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 324057008305 Walker A/P-loop; other site 324057008306 ATP binding site [chemical binding]; other site 324057008307 Q-loop/lid; other site 324057008308 ABC transporter signature motif; other site 324057008309 Walker B; other site 324057008310 D-loop; other site 324057008311 H-loop/switch region; other site 324057008312 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 324057008313 Walker A/P-loop; other site 324057008314 ATP binding site [chemical binding]; other site 324057008315 Q-loop/lid; other site 324057008316 ABC transporter signature motif; other site 324057008317 Walker B; other site 324057008318 D-loop; other site 324057008319 H-loop/switch region; other site 324057008320 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 324057008321 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057008322 LysE type translocator; Region: LysE; cl00565 324057008323 YceI-like domain; Region: YceI; cl01001 324057008324 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 324057008325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008327 Coenzyme A binding pocket [chemical binding]; other site 324057008328 putative acetyltransferase; Provisional; Region: PRK03624 324057008329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057008330 Helix-turn-helix domains; Region: HTH; cl00088 324057008331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057008332 dimerization interface [polypeptide binding]; other site 324057008333 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 324057008334 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 324057008335 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 324057008336 transketolase; Reviewed; Region: PRK05899 324057008337 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 324057008338 TPP-binding site [chemical binding]; other site 324057008339 dimer interface [polypeptide binding]; other site 324057008340 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324057008341 PYR/PP interface [polypeptide binding]; other site 324057008342 dimer interface [polypeptide binding]; other site 324057008343 TPP binding site [chemical binding]; other site 324057008344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057008345 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 324057008346 active site 324057008347 intersubunit interactions; other site 324057008348 catalytic residue [active] 324057008349 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 324057008350 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 324057008351 nudix motif; other site 324057008352 Chromate transporter; Region: Chromate_transp; pfam02417 324057008353 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 324057008354 Chromate transporter; Region: Chromate_transp; pfam02417 324057008355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008356 Coenzyme A binding pocket [chemical binding]; other site 324057008357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057008358 substrate binding site [chemical binding]; other site 324057008359 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 324057008360 short chain dehydrogenase; Provisional; Region: PRK06924 324057008361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008362 NAD(P) binding site [chemical binding]; other site 324057008363 active site 324057008364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008365 S-adenosylmethionine binding site [chemical binding]; other site 324057008366 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057008367 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057008368 secreted effector protein PipB; Provisional; Region: PRK15197 324057008369 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057008370 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057008371 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057008372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057008374 active site 324057008375 metal binding site [ion binding]; metal-binding site 324057008376 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 324057008377 dimer interface [polypeptide binding]; other site 324057008378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008379 ligand binding site [chemical binding]; other site 324057008380 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057008381 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057008382 DEAD-box ATP-dependent RNA helicase; Provisional; Region: PLN00206 324057008383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057008384 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 324057008385 ATP binding site [chemical binding]; other site 324057008386 putative Mg++ binding site [ion binding]; other site 324057008387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057008388 nucleotide binding region [chemical binding]; other site 324057008389 ATP-binding site [chemical binding]; other site 324057008390 DEAD/H associated; Region: DEAD_assoc; pfam08494 324057008391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008392 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057008393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008394 Walker A/P-loop; other site 324057008395 ATP binding site [chemical binding]; other site 324057008396 Q-loop/lid; other site 324057008397 ABC transporter signature motif; other site 324057008398 Walker B; other site 324057008399 D-loop; other site 324057008400 H-loop/switch region; other site 324057008401 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008402 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057008403 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 324057008404 Walker A/P-loop; other site 324057008405 ATP binding site [chemical binding]; other site 324057008406 Q-loop/lid; other site 324057008407 ABC transporter signature motif; other site 324057008408 Walker B; other site 324057008409 D-loop; other site 324057008410 H-loop/switch region; other site 324057008411 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057008412 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057008413 active site 324057008414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057008415 FeS/SAM binding site; other site 324057008416 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 324057008417 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 324057008418 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 324057008419 putative Cl- selectivity filter; other site 324057008420 putative pore gating glutamate residue; other site 324057008421 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057008422 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 324057008423 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 324057008424 putative oligomer interface [polypeptide binding]; other site 324057008425 putative active site [active] 324057008426 metal binding site [ion binding]; metal-binding site 324057008427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057008428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008429 ATP binding site [chemical binding]; other site 324057008430 Mg2+ binding site [ion binding]; other site 324057008431 G-X-G motif; other site 324057008432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057008433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008434 active site 324057008435 phosphorylation site [posttranslational modification] 324057008436 intermolecular recognition site; other site 324057008437 dimerization interface [polypeptide binding]; other site 324057008438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057008439 DNA binding residues [nucleotide binding] 324057008440 dimerization interface [polypeptide binding]; other site 324057008441 DoxX-like family; Region: DoxX_3; pfam13781 324057008442 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 324057008443 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057008444 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057008445 Zn2+ binding site [ion binding]; other site 324057008446 Mg2+ binding site [ion binding]; other site 324057008447 Response regulator receiver domain; Region: Response_reg; pfam00072 324057008448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008449 active site 324057008450 phosphorylation site [posttranslational modification] 324057008451 intermolecular recognition site; other site 324057008452 dimerization interface [polypeptide binding]; other site 324057008453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057008454 metal binding site [ion binding]; metal-binding site 324057008455 active site 324057008456 I-site; other site 324057008457 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057008458 GAF domain; Region: GAF; cl15785 324057008459 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057008460 GAF domain; Region: GAF; cl15785 324057008461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057008462 dimer interface [polypeptide binding]; other site 324057008463 phosphorylation site [posttranslational modification] 324057008464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008465 ATP binding site [chemical binding]; other site 324057008466 G-X-G motif; other site 324057008467 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 324057008468 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057008469 PYR/PP interface [polypeptide binding]; other site 324057008470 dimer interface [polypeptide binding]; other site 324057008471 TPP binding site [chemical binding]; other site 324057008472 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 324057008473 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 324057008474 TPP-binding site [chemical binding]; other site 324057008475 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057008476 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 324057008477 active site 324057008478 metal binding site [ion binding]; metal-binding site 324057008479 catalytic site [active] 324057008480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008481 benzoate transport; Region: 2A0115; TIGR00895 324057008482 putative substrate translocation pore; other site 324057008483 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057008484 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057008485 Spore germination protein; Region: Spore_permease; cl15802 324057008486 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 324057008487 ParB-like nuclease domain; Region: ParBc; cl02129 324057008488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057008489 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 324057008490 putative NAD(P) binding site [chemical binding]; other site 324057008491 active site 324057008492 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057008493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008494 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057008495 putative substrate translocation pore; other site 324057008496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008497 Helix-turn-helix domains; Region: HTH; cl00088 324057008498 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 324057008499 Bacterial SH3 domain; Region: SH3_3; cl02551 324057008500 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 324057008501 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 324057008502 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324057008503 VanW like protein; Region: VanW; pfam04294 324057008504 translocation protein TolB; Provisional; Region: tolB; PRK02889 324057008505 Domain of unknown function (DUF718); Region: DUF718; cl01281 324057008506 cell division protein GpsB; Provisional; Region: PRK14127 324057008507 DivIVA domain; Region: DivI1A_domain; TIGR03544 324057008508 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 324057008509 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057008510 ATP binding site [chemical binding]; other site 324057008511 Mg++ binding site [ion binding]; other site 324057008512 motif III; other site 324057008513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057008514 nucleotide binding region [chemical binding]; other site 324057008515 ATP-binding site [chemical binding]; other site 324057008516 DbpA RNA binding domain; Region: DbpA; pfam03880 324057008517 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057008518 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008519 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008520 ABC transporter; Region: ABC_tran_2; pfam12848 324057008521 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057008523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057008524 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057008525 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057008526 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057008527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008528 Walker A/P-loop; other site 324057008529 ATP binding site [chemical binding]; other site 324057008530 Q-loop/lid; other site 324057008531 ABC transporter signature motif; other site 324057008532 Walker B; other site 324057008533 D-loop; other site 324057008534 H-loop/switch region; other site 324057008535 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 324057008536 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057008537 DNA binding residues [nucleotide binding] 324057008538 dimer interface [polypeptide binding]; other site 324057008539 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 324057008540 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057008541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324057008542 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 324057008543 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324057008544 dimer interface [polypeptide binding]; other site 324057008545 active site 324057008546 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 324057008547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008548 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057008549 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057008550 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324057008551 active site 324057008552 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 324057008553 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 324057008554 tetramer interface [polypeptide binding]; other site 324057008555 active site 324057008556 Mg2+/Mn2+ binding site [ion binding]; other site 324057008557 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 324057008558 dimer interface [polypeptide binding]; other site 324057008559 Citrate synthase; Region: Citrate_synt; pfam00285 324057008560 active site 324057008561 citrylCoA binding site [chemical binding]; other site 324057008562 oxalacetate/citrate binding site [chemical binding]; other site 324057008563 coenzyme A binding site [chemical binding]; other site 324057008564 catalytic triad [active] 324057008565 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 324057008566 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057008567 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008568 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008569 ABC transporter; Region: ABC_tran_2; pfam12848 324057008570 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008571 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 324057008572 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 324057008573 MOSC domain; Region: MOSC; pfam03473 324057008574 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324057008575 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057008576 metal-binding site [ion binding] 324057008577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057008578 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057008579 Transcriptional regulator; Region: Transcrip_reg; cl00361 324057008580 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057008581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057008582 active site 324057008583 catalytic tetrad [active] 324057008584 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057008585 extended (e) SDRs; Region: SDR_e; cd08946 324057008586 NAD(P) binding site [chemical binding]; other site 324057008587 active site 324057008588 substrate binding site [chemical binding]; other site 324057008589 EamA-like transporter family; Region: EamA; cl01037 324057008590 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 324057008591 VanZ like family; Region: VanZ; cl01971 324057008592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057008593 Helix-turn-helix domains; Region: HTH; cl00088 324057008594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057008596 putative substrate translocation pore; other site 324057008597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008598 Chorismate mutase type II; Region: CM_2; cl00693 324057008599 Spore germination protein; Region: Spore_permease; cl15802 324057008600 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057008601 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057008602 LysE type translocator; Region: LysE; cl00565 324057008603 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057008604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057008605 DNA-binding site [nucleotide binding]; DNA binding site 324057008606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057008607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057008608 homodimer interface [polypeptide binding]; other site 324057008609 catalytic residue [active] 324057008610 OpgC protein; Region: OpgC_C; cl00792 324057008611 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 324057008612 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 324057008613 catalytic triad [active] 324057008614 catalytic triad [active] 324057008615 oxyanion hole [active] 324057008616 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057008617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057008618 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057008619 DNA binding residues [nucleotide binding] 324057008620 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057008621 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057008622 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 324057008623 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 324057008624 putative NAD(P) binding site [chemical binding]; other site 324057008625 active site 324057008626 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057008627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008628 dimer interface [polypeptide binding]; other site 324057008629 conserved gate region; other site 324057008630 putative PBP binding loops; other site 324057008631 ABC-ATPase subunit interface; other site 324057008632 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057008633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057008634 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 324057008635 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 324057008636 Walker A/P-loop; other site 324057008637 ATP binding site [chemical binding]; other site 324057008638 Q-loop/lid; other site 324057008639 ABC transporter signature motif; other site 324057008640 Walker B; other site 324057008641 D-loop; other site 324057008642 H-loop/switch region; other site 324057008643 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 324057008644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057008645 substrate binding pocket [chemical binding]; other site 324057008646 membrane-bound complex binding site; other site 324057008647 hinge residues; other site 324057008648 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 324057008649 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 324057008650 active site 324057008651 metal binding site [ion binding]; metal-binding site 324057008652 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057008653 amino acid transporter; Region: 2A0306; TIGR00909 324057008654 Spore germination protein; Region: Spore_permease; cl15802 324057008655 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 324057008656 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 324057008657 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 324057008658 urea carboxylase; Region: urea_carbox; TIGR02712 324057008659 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057008660 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057008661 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 324057008662 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 324057008663 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 324057008664 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324057008665 carboxyltransferase (CT) interaction site; other site 324057008666 biotinylation site [posttranslational modification]; other site 324057008667 allophanate hydrolase; Provisional; Region: PRK08186 324057008668 Amidase; Region: Amidase; cl11426 324057008669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008670 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 324057008671 active site 324057008672 DinB superfamily; Region: DinB_2; pfam12867 324057008673 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 324057008674 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 324057008675 MOSC domain; Region: MOSC; pfam03473 324057008676 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 324057008677 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057008678 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057008679 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057008680 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057008681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057008682 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057008683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057008684 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057008685 Spore germination protein; Region: Spore_permease; cl15802 324057008686 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057008687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057008689 putative substrate translocation pore; other site 324057008690 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057008691 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057008692 Predicted ATPase [General function prediction only]; Region: COG3910 324057008693 ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterised by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are...; Region: ABC_Class2; cd03227 324057008694 Walker A/P-loop; other site 324057008695 ATP binding site [chemical binding]; other site 324057008696 Q-loop/lid; other site 324057008697 ABC transporter signature motif; other site 324057008698 Walker B; other site 324057008699 D-loop; other site 324057008700 H-loop/switch region; other site 324057008701 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 324057008702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057008703 Helix-turn-helix domains; Region: HTH; cl00088 324057008704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057008705 dimerization interface [polypeptide binding]; other site 324057008706 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 324057008707 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 324057008708 THF binding site; other site 324057008709 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 324057008710 substrate binding site [chemical binding]; other site 324057008711 THF binding site; other site 324057008712 zinc-binding site [ion binding]; other site 324057008713 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 324057008714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057008715 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057008716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008717 Walker A/P-loop; other site 324057008718 ATP binding site [chemical binding]; other site 324057008719 Q-loop/lid; other site 324057008720 ABC transporter signature motif; other site 324057008721 Walker B; other site 324057008722 D-loop; other site 324057008723 H-loop/switch region; other site 324057008724 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057008725 Spore germination protein; Region: Spore_permease; cl15802 324057008726 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057008727 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 324057008728 Protein of unknown function (DUF420); Region: DUF420; cl00989 324057008729 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057008730 active site 324057008731 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057008732 putative metal binding site [ion binding]; other site 324057008733 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057008734 putative metal binding site [ion binding]; other site 324057008735 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057008736 putative metal binding site [ion binding]; other site 324057008737 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057008738 putative metal binding site [ion binding]; other site 324057008739 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 324057008740 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057008741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008742 putative substrate translocation pore; other site 324057008743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057008744 putative DNA binding site [nucleotide binding]; other site 324057008745 dimerization interface [polypeptide binding]; other site 324057008746 putative Zn2+ binding site [ion binding]; other site 324057008747 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057008748 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057008749 DNA binding site [nucleotide binding] 324057008750 domain linker motif; other site 324057008751 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057008752 ligand binding site [chemical binding]; other site 324057008753 dimerization interface [polypeptide binding]; other site 324057008754 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057008756 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057008757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057008758 hypothetical protein; Provisional; Region: PRK07945 324057008759 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324057008760 PHP-associated; Region: PHP_C; pfam13263 324057008761 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057008762 Helix-turn-helix domains; Region: HTH; cl00088 324057008763 WYL domain; Region: WYL; cl14852 324057008764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057008765 non-specific DNA binding site [nucleotide binding]; other site 324057008766 salt bridge; other site 324057008767 sequence-specific DNA binding site [nucleotide binding]; other site 324057008768 short chain dehydrogenase; Provisional; Region: PRK06197 324057008769 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 324057008770 putative NAD(P) binding site [chemical binding]; other site 324057008771 active site 324057008772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057008773 Helix-turn-helix domains; Region: HTH; cl00088 324057008774 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057008775 catalytic core [active] 324057008776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057008777 active site 324057008778 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057008779 catalytic tetrad [active] 324057008780 S-layer homology domain; Region: SLH; pfam00395 324057008781 Bacterial Ig-like domain; Region: Big_5; cl01012 324057008782 Bacterial Ig-like domain; Region: Big_5; cl01012 324057008783 Bacterial Ig-like domain; Region: Big_5; cl01012 324057008784 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 324057008785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057008786 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057008787 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057008788 Bacterial SH3 domain; Region: SH3_3; cl02551 324057008789 Bacterial SH3 domain; Region: SH3_3; cl02551 324057008790 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 324057008791 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057008792 active site 324057008793 metal binding site [ion binding]; metal-binding site 324057008794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008795 S-adenosylmethionine binding site [chemical binding]; other site 324057008796 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 324057008797 Sm1 motif; other site 324057008798 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 324057008799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008800 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057008801 active site 324057008802 metal binding site [ion binding]; metal-binding site 324057008803 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057008804 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 324057008805 Walker A/P-loop; other site 324057008806 ATP binding site [chemical binding]; other site 324057008807 Q-loop/lid; other site 324057008808 ABC transporter signature motif; other site 324057008809 Walker B; other site 324057008810 D-loop; other site 324057008811 H-loop/switch region; other site 324057008812 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057008813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057008814 substrate binding pocket [chemical binding]; other site 324057008815 membrane-bound complex binding site; other site 324057008816 hinge residues; other site 324057008817 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324057008818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008819 dimer interface [polypeptide binding]; other site 324057008820 conserved gate region; other site 324057008821 putative PBP binding loops; other site 324057008822 ABC-ATPase subunit interface; other site 324057008823 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324057008824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008825 dimer interface [polypeptide binding]; other site 324057008826 conserved gate region; other site 324057008827 putative PBP binding loops; other site 324057008828 ABC-ATPase subunit interface; other site 324057008829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057008830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008831 ATP binding site [chemical binding]; other site 324057008832 Mg2+ binding site [ion binding]; other site 324057008833 G-X-G motif; other site 324057008834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008835 Response regulator receiver domain; Region: Response_reg; pfam00072 324057008836 active site 324057008837 phosphorylation site [posttranslational modification] 324057008838 intermolecular recognition site; other site 324057008839 dimerization interface [polypeptide binding]; other site 324057008840 YcbB domain; Region: YcbB; pfam08664 324057008841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057008842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008843 dimer interface [polypeptide binding]; other site 324057008844 conserved gate region; other site 324057008845 putative PBP binding loops; other site 324057008846 ABC-ATPase subunit interface; other site 324057008847 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057008848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008849 dimer interface [polypeptide binding]; other site 324057008850 putative PBP binding loops; other site 324057008851 ABC-ATPase subunit interface; other site 324057008852 hypothetical protein; Provisional; Region: PRK06851 324057008853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008854 germination protein YpeB; Region: spore_YpeB; TIGR02889 324057008855 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324057008856 Helix-turn-helix domains; Region: HTH; cl00088 324057008857 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057008858 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008859 ABC transporter; Region: ABC_tran_2; pfam12848 324057008860 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057008861 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057008862 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 324057008863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008864 S-adenosylmethionine binding site [chemical binding]; other site 324057008865 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 324057008866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008867 putative substrate translocation pore; other site 324057008868 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 324057008869 Helix-turn-helix domains; Region: HTH; cl00088 324057008870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057008871 dimerization interface [polypeptide binding]; other site 324057008872 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057008873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057008874 DNA binding site [nucleotide binding] 324057008875 domain linker motif; other site 324057008876 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057008877 dimerization interface [polypeptide binding]; other site 324057008878 ligand binding site [chemical binding]; other site 324057008879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008880 dimer interface [polypeptide binding]; other site 324057008881 conserved gate region; other site 324057008882 putative PBP binding loops; other site 324057008883 ABC-ATPase subunit interface; other site 324057008884 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057008885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057008886 Walker A/P-loop; other site 324057008887 ATP binding site [chemical binding]; other site 324057008888 Q-loop/lid; other site 324057008889 ABC transporter signature motif; other site 324057008890 Walker B; other site 324057008891 D-loop; other site 324057008892 H-loop/switch region; other site 324057008893 TOBE domain; Region: TOBE_2; cl01440 324057008894 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057008895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057008896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008897 dimer interface [polypeptide binding]; other site 324057008898 conserved gate region; other site 324057008899 putative PBP binding loops; other site 324057008900 ABC-ATPase subunit interface; other site 324057008901 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324057008902 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 324057008903 active site 324057008904 catalytic site [active] 324057008905 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 324057008906 metal binding site [ion binding]; metal-binding site 324057008907 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 324057008908 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057008909 PYR/PP interface [polypeptide binding]; other site 324057008910 dimer interface [polypeptide binding]; other site 324057008911 TPP binding site [chemical binding]; other site 324057008912 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 324057008913 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324057008914 TPP-binding site [chemical binding]; other site 324057008915 dimer interface [polypeptide binding]; other site 324057008916 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 324057008917 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 324057008918 putative valine binding site [chemical binding]; other site 324057008919 dimer interface [polypeptide binding]; other site 324057008920 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 324057008921 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057008922 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057008923 Spore germination protein; Region: Spore_permease; cl15802 324057008924 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 324057008925 gating phenylalanine in ion channel; other site 324057008926 lysine transporter; Provisional; Region: PRK10836 324057008927 Spore germination protein; Region: Spore_permease; cl15802 324057008928 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008929 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008930 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008931 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008932 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008933 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008934 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008935 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008936 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008937 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008938 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057008939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057008940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008941 putative substrate translocation pore; other site 324057008942 Cupin domain; Region: Cupin_2; cl09118 324057008943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008944 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057008945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008947 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057008948 Glucuronate isomerase; Region: UxaC; cl00829 324057008949 altronate oxidoreductase; Provisional; Region: PRK03643 324057008950 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 324057008951 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 324057008952 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 324057008953 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 324057008954 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 324057008955 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 324057008956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008957 putative substrate translocation pore; other site 324057008958 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057008959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057008960 DNA-binding site [nucleotide binding]; DNA binding site 324057008961 FCD domain; Region: FCD; cl11656 324057008962 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 324057008963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057008964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057008965 Uncharacterized conserved protein [Function unknown]; Region: COG2128 324057008966 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 324057008967 H+ Antiporter protein; Region: 2A0121; TIGR00900 324057008968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008969 putative substrate translocation pore; other site 324057008970 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324057008971 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 324057008972 [2Fe-2S] cluster binding site [ion binding]; other site 324057008973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057008974 Helix-turn-helix domains; Region: HTH; cl00088 324057008975 Isochorismatase family; Region: Isochorismatase; pfam00857 324057008976 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324057008977 catalytic triad [active] 324057008978 conserved cis-peptide bond; other site 324057008979 drug efflux system protein MdtG; Provisional; Region: PRK09874 324057008980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008981 putative substrate translocation pore; other site 324057008982 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 324057008983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008984 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 324057008985 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 324057008986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008987 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 324057008988 Uncharacterized conserved protein [Function unknown]; Region: COG3595 324057008989 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057008990 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 324057008991 Helix-turn-helix domains; Region: HTH; cl00088 324057008992 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 324057008993 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 324057008994 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 324057008995 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 324057008996 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 324057008997 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057008998 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324057008999 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324057009000 DNA binding site [nucleotide binding] 324057009001 active site 324057009002 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 324057009003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057009004 S-adenosylmethionine binding site [chemical binding]; other site 324057009005 Protein of unknown function, DUF606; Region: DUF606; cl01273 324057009006 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 324057009007 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324057009008 ligand binding site [chemical binding]; other site 324057009009 flexible hinge region; other site 324057009010 Helix-turn-helix domains; Region: HTH; cl00088 324057009011 Protein of unknown function, DUF606; Region: DUF606; cl01273 324057009012 AzlC protein; Region: AzlC; cl00570 324057009013 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 324057009014 Transglycosylase; Region: Transgly; cl07896 324057009015 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057009016 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057009017 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 324057009018 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057009019 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057009020 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057009021 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 324057009022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009023 Family description; Region: UvrD_C_2; cl15862 324057009024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009025 Helix-turn-helix domains; Region: HTH; cl00088 324057009026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009027 dimerization interface [polypeptide binding]; other site 324057009028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057009029 Carboxylesterase family; Region: COesterase; pfam00135 324057009030 substrate binding pocket [chemical binding]; other site 324057009031 catalytic triad [active] 324057009032 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 324057009033 Isochorismatase family; Region: Isochorismatase; pfam00857 324057009034 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 324057009035 catalytic triad [active] 324057009036 conserved cis-peptide bond; other site 324057009037 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 324057009038 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 324057009039 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057009040 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057009041 classical (c) SDRs; Region: SDR_c; cd05233 324057009042 NAD(P) binding site [chemical binding]; other site 324057009043 active site 324057009044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009045 Helix-turn-helix domains; Region: HTH; cl00088 324057009046 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057009047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009048 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009049 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009050 Spore germination protein; Region: Spore_permease; cl15802 324057009051 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009052 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009053 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057009054 Helix-turn-helix domains; Region: HTH; cl00088 324057009055 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057009056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009057 Ion channel; Region: Ion_trans_2; cl11596 324057009058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057009060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057009061 S-adenosylmethionine binding site [chemical binding]; other site 324057009062 FAD dependent oxidoreductase; Region: DAO; pfam01266 324057009063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009064 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057009065 Cupin domain; Region: Cupin_2; cl09118 324057009066 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 324057009067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009068 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 324057009069 active site 324057009070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009072 dimerization interface [polypeptide binding]; other site 324057009073 Histidine kinase; Region: His_kinase; pfam06580 324057009074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009075 ATP binding site [chemical binding]; other site 324057009076 Mg2+ binding site [ion binding]; other site 324057009077 G-X-G motif; other site 324057009078 Response regulator receiver domain; Region: Response_reg; pfam00072 324057009079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009080 active site 324057009081 phosphorylation site [posttranslational modification] 324057009082 intermolecular recognition site; other site 324057009083 dimerization interface [polypeptide binding]; other site 324057009084 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057009085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009086 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057009087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057009088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057009089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057009090 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009091 Cupin domain; Region: Cupin_2; cl09118 324057009092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009095 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057009096 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057009097 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057009098 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 324057009099 heme binding pocket [chemical binding]; other site 324057009100 YolD-like protein; Region: YolD; pfam08863 324057009101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009102 Helix-turn-helix domains; Region: HTH; cl00088 324057009103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057009104 dimerization interface [polypeptide binding]; other site 324057009105 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 324057009106 amidohydrolase; Region: amidohydrolases; TIGR01891 324057009107 metal binding site [ion binding]; metal-binding site 324057009108 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 324057009109 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 324057009110 galactonate dehydratase; Provisional; Region: PRK14017 324057009111 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 324057009112 putative active site pocket [active] 324057009113 putative metal binding site [ion binding]; other site 324057009114 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 324057009115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057009116 motif II; other site 324057009117 Right handed beta helix region; Region: Beta_helix; pfam13229 324057009118 beta-D-glucuronidase; Provisional; Region: PRK10150 324057009119 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057009120 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057009121 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057009122 Cupin domain; Region: Cupin_2; cl09118 324057009123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009124 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009126 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009127 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 324057009128 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009129 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009130 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009131 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009132 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009133 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009134 Predicted membrane protein [Function unknown]; Region: COG1470 324057009135 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009136 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057009137 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057009138 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009139 dimerization interface [polypeptide binding]; other site 324057009140 putative DNA binding site [nucleotide binding]; other site 324057009141 putative Zn2+ binding site [ion binding]; other site 324057009142 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 324057009143 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 324057009144 NADP binding site [chemical binding]; other site 324057009145 putative substrate binding site [chemical binding]; other site 324057009146 active site 324057009147 Predicted acetyltransferase [General function prediction only]; Region: COG3393 324057009148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057009149 Coenzyme A binding pocket [chemical binding]; other site 324057009150 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 324057009151 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 324057009152 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 324057009153 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057009154 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057009155 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 324057009156 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 324057009157 putative ligand binding site [chemical binding]; other site 324057009158 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 324057009159 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 324057009160 iron-sulfur cluster [ion binding]; other site 324057009161 [2Fe-2S] cluster binding site [ion binding]; other site 324057009162 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057009163 hydrophobic ligand binding site; other site 324057009164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009166 active site 324057009167 phosphorylation site [posttranslational modification] 324057009168 intermolecular recognition site; other site 324057009169 dimerization interface [polypeptide binding]; other site 324057009170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009171 DNA binding site [nucleotide binding] 324057009172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009174 dimerization interface [polypeptide binding]; other site 324057009175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009176 dimer interface [polypeptide binding]; other site 324057009177 phosphorylation site [posttranslational modification] 324057009178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009179 ATP binding site [chemical binding]; other site 324057009180 Mg2+ binding site [ion binding]; other site 324057009181 G-X-G motif; other site 324057009182 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 324057009183 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 324057009184 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 324057009185 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057009186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009187 putative substrate translocation pore; other site 324057009188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009189 Cupin domain; Region: Cupin_2; cl09118 324057009190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009192 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057009193 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 324057009194 active site 324057009195 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057009196 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057009197 Cupin domain; Region: Cupin_2; cl09118 324057009198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009199 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009201 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 324057009202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009203 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 324057009204 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 324057009205 metal ion-dependent adhesion site (MIDAS); other site 324057009206 stage V sporulation protein B; Region: spore_V_B; TIGR02900 324057009207 MatE; Region: MatE; cl10513 324057009208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057009209 binding surface 324057009210 TPR motif; other site 324057009211 Tetratrico peptide repeat; Region: TPR_5; pfam12688 324057009212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057009213 binding surface 324057009214 TPR motif; other site 324057009215 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057009216 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057009217 active site 324057009218 catalytic tetrad [active] 324057009219 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 324057009220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009222 active site 324057009223 phosphorylation site [posttranslational modification] 324057009224 intermolecular recognition site; other site 324057009225 dimerization interface [polypeptide binding]; other site 324057009226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009227 DNA binding site [nucleotide binding] 324057009228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009229 dimerization interface [polypeptide binding]; other site 324057009230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009231 dimer interface [polypeptide binding]; other site 324057009232 phosphorylation site [posttranslational modification] 324057009233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009234 ATP binding site [chemical binding]; other site 324057009235 Mg2+ binding site [ion binding]; other site 324057009236 G-X-G motif; other site 324057009237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009238 Walker A/P-loop; other site 324057009239 ATP binding site [chemical binding]; other site 324057009240 Q-loop/lid; other site 324057009241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009242 ABC transporter signature motif; other site 324057009243 ABC transporter signature motif; other site 324057009244 Walker B; other site 324057009245 D-loop; other site 324057009246 H-loop/switch region; other site 324057009247 short chain dehydrogenase; Provisional; Region: PRK06701 324057009248 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 324057009249 NAD binding site [chemical binding]; other site 324057009250 metal binding site [ion binding]; metal-binding site 324057009251 active site 324057009252 Domain of unknown function (DUF336); Region: DUF336; cl01249 324057009253 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057009254 Helix-turn-helix domains; Region: HTH; cl00088 324057009255 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057009256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057009257 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057009258 active site 324057009259 motif I; other site 324057009260 motif II; other site 324057009261 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057009262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009263 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 324057009264 putative substrate translocation pore; other site 324057009265 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 324057009266 Clp protease; Region: CLP_protease; pfam00574 324057009267 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324057009268 oligomer interface [polypeptide binding]; other site 324057009269 active site residues [active] 324057009270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057009271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057009272 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009273 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009274 Spore germination protein; Region: Spore_permease; cl15802 324057009275 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057009276 Helix-turn-helix domains; Region: HTH; cl00088 324057009277 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324057009278 phosphopeptide binding site; other site 324057009279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009280 DNA binding site [nucleotide binding] 324057009281 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057009282 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057009283 hinge; other site 324057009284 active site 324057009285 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009286 Spore germination protein; Region: Spore_permease; cl15802 324057009287 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009289 Helix-turn-helix domains; Region: HTH; cl00088 324057009290 short chain dehydrogenase; Provisional; Region: PRK06180 324057009291 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057009292 NADP binding site [chemical binding]; other site 324057009293 active site 324057009294 steroid binding site; other site 324057009295 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057009296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009297 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057009298 putative substrate translocation pore; other site 324057009299 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 324057009300 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324057009301 active site 324057009302 DNA binding site [nucleotide binding] 324057009303 Int/Topo IB signature motif; other site 324057009304 Isochorismatase family; Region: Isochorismatase; pfam00857 324057009305 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324057009306 catalytic triad [active] 324057009307 conserved cis-peptide bond; other site 324057009308 BNR repeat-like domain; Region: BNR_2; pfam13088 324057009309 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057009310 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 324057009311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057009312 ABC-ATPase subunit interface; other site 324057009313 dimer interface [polypeptide binding]; other site 324057009314 putative PBP binding regions; other site 324057009315 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 324057009316 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 324057009317 metal binding site [ion binding]; metal-binding site 324057009318 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 324057009319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 324057009321 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057009322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057009323 Coenzyme A binding pocket [chemical binding]; other site 324057009324 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 324057009325 putative hydrophobic ligand binding site [chemical binding]; other site 324057009326 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 324057009327 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057009328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009329 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057009330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009331 NAD(P) binding site [chemical binding]; other site 324057009332 active site 324057009333 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009334 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009335 Spore germination protein; Region: Spore_permease; cl15802 324057009336 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057009337 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057009338 intersubunit interface [polypeptide binding]; other site 324057009339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009342 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057009343 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057009344 intersubunit interface [polypeptide binding]; other site 324057009345 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 324057009346 PAS domain S-box; Region: sensory_box; TIGR00229 324057009347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057009348 putative active site [active] 324057009349 heme pocket [chemical binding]; other site 324057009350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057009351 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057009352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009353 dimer interface [polypeptide binding]; other site 324057009354 phosphorylation site [posttranslational modification] 324057009355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009356 ATP binding site [chemical binding]; other site 324057009357 Mg2+ binding site [ion binding]; other site 324057009358 G-X-G motif; other site 324057009359 Response regulator receiver domain; Region: Response_reg; pfam00072 324057009360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009361 active site 324057009362 phosphorylation site [posttranslational modification] 324057009363 intermolecular recognition site; other site 324057009364 dimerization interface [polypeptide binding]; other site 324057009365 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057009366 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057009367 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057009368 Protease prsW family; Region: PrsW-protease; cl15823 324057009369 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057009370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057009371 Coenzyme A binding pocket [chemical binding]; other site 324057009372 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057009373 active site 324057009374 ATP binding site [chemical binding]; other site 324057009375 amidase; Provisional; Region: PRK06828 324057009376 Amidase; Region: Amidase; cl11426 324057009377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009380 Helix-turn-helix domains; Region: HTH; cl00088 324057009381 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009382 dimerization interface [polypeptide binding]; other site 324057009383 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057009384 DinB superfamily; Region: DinB_2; pfam12867 324057009385 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 324057009386 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057009387 active site 324057009388 Cupin domain; Region: Cupin_2; cl09118 324057009389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009391 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057009392 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057009393 Phosphotransferase enzyme family; Region: APH; pfam01636 324057009394 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057009395 active site 324057009396 ATP binding site [chemical binding]; other site 324057009397 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057009398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009400 active site 324057009401 phosphorylation site [posttranslational modification] 324057009402 intermolecular recognition site; other site 324057009403 dimerization interface [polypeptide binding]; other site 324057009404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009405 DNA binding site [nucleotide binding] 324057009406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009407 dimerization interface [polypeptide binding]; other site 324057009408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009409 dimer interface [polypeptide binding]; other site 324057009410 phosphorylation site [posttranslational modification] 324057009411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009412 ATP binding site [chemical binding]; other site 324057009413 Mg2+ binding site [ion binding]; other site 324057009414 G-X-G motif; other site 324057009415 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009416 dimerization interface [polypeptide binding]; other site 324057009417 putative DNA binding site [nucleotide binding]; other site 324057009418 putative Zn2+ binding site [ion binding]; other site 324057009419 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057009420 putative hydrophobic ligand binding site [chemical binding]; other site 324057009421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009422 Walker A/P-loop; other site 324057009423 ATP binding site [chemical binding]; other site 324057009424 Q-loop/lid; other site 324057009425 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 324057009426 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 324057009427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009428 Walker A/P-loop; other site 324057009429 ATP binding site [chemical binding]; other site 324057009430 Q-loop/lid; other site 324057009431 ABC transporter signature motif; other site 324057009432 Walker B; other site 324057009433 D-loop; other site 324057009434 H-loop/switch region; other site 324057009435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009436 Helix-turn-helix domains; Region: HTH; cl00088 324057009437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057009438 dimerization interface [polypeptide binding]; other site 324057009439 Spore germination protein; Region: Spore_permease; cl15802 324057009440 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009441 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009442 Protein of unknown function (DUF419); Region: DUF419; cl15265 324057009443 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057009444 DinB superfamily; Region: DinB_2; pfam12867 324057009445 short chain dehydrogenase; Provisional; Region: PRK07062 324057009446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009447 NAD(P) binding site [chemical binding]; other site 324057009448 active site 324057009449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009450 Helix-turn-helix domains; Region: HTH; cl00088 324057009451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009452 putative substrate translocation pore; other site 324057009453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009454 Phosphotransferase enzyme family; Region: APH; pfam01636 324057009455 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057009456 active site 324057009457 substrate binding site [chemical binding]; other site 324057009458 ATP binding site [chemical binding]; other site 324057009459 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 324057009460 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324057009461 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057009462 putative metal binding site [ion binding]; other site 324057009463 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057009464 putative metal binding site [ion binding]; other site 324057009465 EcsC protein family; Region: EcsC; pfam12787 324057009466 NIPSNAP; Region: NIPSNAP; pfam07978 324057009467 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057009468 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057009469 classical (c) SDRs; Region: SDR_c; cd05233 324057009470 NAD(P) binding site [chemical binding]; other site 324057009471 active site 324057009472 NIPSNAP; Region: NIPSNAP; pfam07978 324057009473 Nitronate monooxygenase; Region: NMO; pfam03060 324057009474 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 324057009475 FMN binding site [chemical binding]; other site 324057009476 substrate binding site [chemical binding]; other site 324057009477 putative catalytic residue [active] 324057009478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009479 Helix-turn-helix domains; Region: HTH; cl00088 324057009480 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 324057009481 putative dimerization interface [polypeptide binding]; other site 324057009482 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057009483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009484 putative substrate translocation pore; other site 324057009485 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009486 Spore germination protein; Region: Spore_permease; cl15802 324057009487 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 324057009488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009490 active site 324057009491 phosphorylation site [posttranslational modification] 324057009492 intermolecular recognition site; other site 324057009493 dimerization interface [polypeptide binding]; other site 324057009494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009495 DNA binding site [nucleotide binding] 324057009496 sensory histidine kinase CreC; Provisional; Region: PRK11100 324057009497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009498 dimerization interface [polypeptide binding]; other site 324057009499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009500 dimer interface [polypeptide binding]; other site 324057009501 phosphorylation site [posttranslational modification] 324057009502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009503 ATP binding site [chemical binding]; other site 324057009504 Mg2+ binding site [ion binding]; other site 324057009505 G-X-G motif; other site 324057009506 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 324057009507 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009509 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057009510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057009511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009512 putative PBP binding loops; other site 324057009513 dimer interface [polypeptide binding]; other site 324057009514 ABC-ATPase subunit interface; other site 324057009515 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057009516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009517 dimer interface [polypeptide binding]; other site 324057009518 conserved gate region; other site 324057009519 putative PBP binding loops; other site 324057009520 ABC-ATPase subunit interface; other site 324057009521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057009522 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057009523 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 324057009524 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 324057009525 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 324057009526 putative active site [active] 324057009527 catalytic site [active] 324057009528 putative metal binding site [ion binding]; other site 324057009529 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 324057009530 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 324057009531 active site 324057009532 HIGH motif; other site 324057009533 KMSKS motif; other site 324057009534 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 324057009535 tRNA binding surface [nucleotide binding]; other site 324057009536 anticodon binding site; other site 324057009537 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009538 Spore germination protein; Region: Spore_permease; cl15802 324057009539 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009540 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057009541 Helix-turn-helix domains; Region: HTH; cl00088 324057009542 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057009543 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057009544 classical (c) SDRs; Region: SDR_c; cd05233 324057009545 NAD(P) binding site [chemical binding]; other site 324057009546 active site 324057009547 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057009548 Helix-turn-helix domains; Region: HTH; cl00088 324057009549 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057009550 classical (c) SDRs; Region: SDR_c; cd05233 324057009551 NAD(P) binding site [chemical binding]; other site 324057009552 active site 324057009553 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 324057009554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009555 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057009556 NAD(P) binding site [chemical binding]; other site 324057009557 active site 324057009558 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 324057009559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009560 ABC-ATPase subunit interface; other site 324057009561 putative PBP binding loops; other site 324057009562 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057009563 Erythromycin esterase; Region: Erythro_esteras; pfam05139 324057009564 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 324057009565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057009566 FeS/SAM binding site; other site 324057009567 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057009568 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 324057009569 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057009570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009571 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009572 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057009573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009574 dimer interface [polypeptide binding]; other site 324057009575 conserved gate region; other site 324057009576 putative PBP binding loops; other site 324057009577 ABC-ATPase subunit interface; other site 324057009578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009579 dimer interface [polypeptide binding]; other site 324057009580 conserved gate region; other site 324057009581 putative PBP binding loops; other site 324057009582 ABC-ATPase subunit interface; other site 324057009583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009585 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057009586 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009587 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057009588 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009589 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009590 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057009591 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009592 Spore germination protein; Region: Spore_permease; cl15802 324057009593 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057009594 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009595 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057009596 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057009597 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057009598 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057009599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009600 Walker A/P-loop; other site 324057009601 ATP binding site [chemical binding]; other site 324057009602 Q-loop/lid; other site 324057009603 ABC transporter signature motif; other site 324057009604 Walker B; other site 324057009605 D-loop; other site 324057009606 H-loop/switch region; other site 324057009607 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057009608 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057009609 active site 324057009610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057009611 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057009612 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324057009613 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 324057009614 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057009615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057009616 putative active site [active] 324057009617 heme pocket [chemical binding]; other site 324057009618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009619 dimer interface [polypeptide binding]; other site 324057009620 phosphorylation site [posttranslational modification] 324057009621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009622 ATP binding site [chemical binding]; other site 324057009623 Mg2+ binding site [ion binding]; other site 324057009624 G-X-G motif; other site 324057009625 CutC family; Region: CutC; cl01218 324057009626 phosphoenolpyruvate synthase; Validated; Region: PRK06241 324057009627 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 324057009628 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 324057009629 WYL domain; Region: WYL; cl14852 324057009630 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 324057009631 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324057009632 dimerization interface [polypeptide binding]; other site 324057009633 DPS ferroxidase diiron center [ion binding]; other site 324057009634 ion pore; other site 324057009635 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 324057009636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009637 DEAD_2; Region: DEAD_2; pfam06733 324057009638 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057009639 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057009640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057009641 DNA-binding site [nucleotide binding]; DNA binding site 324057009642 FCD domain; Region: FCD; cl11656 324057009643 Dehydratase family; Region: ILVD_EDD; cl00340 324057009644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 324057009645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009647 active site 324057009648 phosphorylation site [posttranslational modification] 324057009649 intermolecular recognition site; other site 324057009650 dimerization interface [polypeptide binding]; other site 324057009651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009652 DNA binding site [nucleotide binding] 324057009653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009655 dimerization interface [polypeptide binding]; other site 324057009656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009657 dimer interface [polypeptide binding]; other site 324057009658 phosphorylation site [posttranslational modification] 324057009659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009660 ATP binding site [chemical binding]; other site 324057009661 Mg2+ binding site [ion binding]; other site 324057009662 G-X-G motif; other site 324057009663 Protein of unknown function (DUF421); Region: DUF421; cl00990 324057009664 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 324057009665 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057009666 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057009667 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 324057009668 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 324057009669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057009670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009671 NAD(P) binding site [chemical binding]; other site 324057009672 active site 324057009673 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 324057009674 substrate binding site [chemical binding]; other site 324057009675 catalytic residues [active] 324057009676 S-layer homology domain; Region: SLH; pfam00395 324057009677 S-layer homology domain; Region: SLH; pfam00395 324057009678 S-layer homology domain; Region: SLH; pfam00395 324057009679 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057009680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057009681 DNA-binding site [nucleotide binding]; DNA binding site 324057009682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057009683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057009684 homodimer interface [polypeptide binding]; other site 324057009685 catalytic residue [active] 324057009686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009687 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 324057009688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009691 dimer interface [polypeptide binding]; other site 324057009692 phosphorylation site [posttranslational modification] 324057009693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009694 ATP binding site [chemical binding]; other site 324057009695 Mg2+ binding site [ion binding]; other site 324057009696 G-X-G motif; other site 324057009697 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056 324057009698 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057009699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057009700 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057009701 putative active site [active] 324057009702 heme pocket [chemical binding]; other site 324057009703 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057009704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057009705 putative active site [active] 324057009706 heme pocket [chemical binding]; other site 324057009707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009708 dimer interface [polypeptide binding]; other site 324057009709 phosphorylation site [posttranslational modification] 324057009710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009711 ATP binding site [chemical binding]; other site 324057009712 Mg2+ binding site [ion binding]; other site 324057009713 G-X-G motif; other site 324057009714 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057009715 active site 324057009716 metal binding site [ion binding]; metal-binding site 324057009717 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 324057009718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057009719 Cupin domain; Region: Cupin_2; cl09118 324057009720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009723 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057009724 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057009725 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 324057009726 putative NAD(P) binding site [chemical binding]; other site 324057009727 active site 324057009728 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057009729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057009730 DNA-binding site [nucleotide binding]; DNA binding site 324057009731 FCD domain; Region: FCD; cl11656 324057009732 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057009733 classical (c) SDRs; Region: SDR_c; cd05233 324057009734 NAD(P) binding site [chemical binding]; other site 324057009735 active site 324057009736 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324057009737 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 324057009738 active site pocket [active] 324057009739 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 324057009740 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057009741 active site 324057009742 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057009743 classical (c) SDRs; Region: SDR_c; cd05233 324057009744 NAD(P) binding site [chemical binding]; other site 324057009745 active site 324057009746 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 324057009747 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 324057009748 Helix-turn-helix domains; Region: HTH; cl00088 324057009749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009750 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057009751 NAD(P) binding site [chemical binding]; other site 324057009752 active site 324057009753 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 324057009754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009756 active site 324057009757 phosphorylation site [posttranslational modification] 324057009758 intermolecular recognition site; other site 324057009759 dimerization interface [polypeptide binding]; other site 324057009760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009761 DNA binding site [nucleotide binding] 324057009762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057009764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009765 dimer interface [polypeptide binding]; other site 324057009766 phosphorylation site [posttranslational modification] 324057009767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009768 ATP binding site [chemical binding]; other site 324057009769 Mg2+ binding site [ion binding]; other site 324057009770 G-X-G motif; other site 324057009771 VanZ like family; Region: VanZ; cl01971 324057009772 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057009773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057009774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057009775 substrate binding pocket [chemical binding]; other site 324057009776 membrane-bound complex binding site; other site 324057009777 hinge residues; other site 324057009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009779 dimer interface [polypeptide binding]; other site 324057009780 conserved gate region; other site 324057009781 putative PBP binding loops; other site 324057009782 ABC-ATPase subunit interface; other site 324057009783 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057009784 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 324057009785 Walker A/P-loop; other site 324057009786 ATP binding site [chemical binding]; other site 324057009787 Q-loop/lid; other site 324057009788 ABC transporter signature motif; other site 324057009789 Walker B; other site 324057009790 D-loop; other site 324057009791 H-loop/switch region; other site 324057009792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057009793 Cupin domain; Region: Cupin_2; cl09118 324057009794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009796 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057009797 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 324057009798 protein binding surface [polypeptide binding]; other site 324057009799 HEAT repeats; Region: HEAT_2; pfam13646 324057009800 FixH; Region: FixH; cl01254 324057009801 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324057009802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009803 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 324057009804 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057009805 active site 324057009806 catalytic triad [active] 324057009807 oxyanion hole [active] 324057009808 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057009809 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 324057009810 Walker A/P-loop; other site 324057009811 ATP binding site [chemical binding]; other site 324057009812 Q-loop/lid; other site 324057009813 ABC transporter signature motif; other site 324057009814 Walker B; other site 324057009815 D-loop; other site 324057009816 H-loop/switch region; other site 324057009817 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057009818 SNF2 Helicase protein; Region: DUF3670; pfam12419 324057009819 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057009820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057009821 ATP binding site [chemical binding]; other site 324057009822 putative Mg++ binding site [ion binding]; other site 324057009823 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057009824 nucleotide binding region [chemical binding]; other site 324057009825 ATP-binding site [chemical binding]; other site 324057009826 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324057009827 active site 324057009828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009829 Helix-turn-helix domains; Region: HTH; cl00088 324057009830 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057009831 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057009832 intersubunit interface [polypeptide binding]; other site 324057009833 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009835 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 324057009836 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057009837 intersubunit interface [polypeptide binding]; other site 324057009838 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057009839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057009841 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057009842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009843 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057009844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057009845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057009847 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 324057009848 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 324057009849 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 324057009850 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 324057009851 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 324057009852 FMN binding site [chemical binding]; other site 324057009853 active site 324057009854 catalytic residues [active] 324057009855 substrate binding site [chemical binding]; other site 324057009856 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 324057009857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057009858 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057009859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009860 Helix-turn-helix domains; Region: HTH; cl00088 324057009861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057009862 dimerization interface [polypeptide binding]; other site 324057009863 putative deaminase; Validated; Region: PRK06846 324057009864 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057009865 active site 324057009866 putative deaminase; Validated; Region: PRK06846 324057009867 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057009868 active site 324057009869 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057009870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009872 active site 324057009873 phosphorylation site [posttranslational modification] 324057009874 intermolecular recognition site; other site 324057009875 dimerization interface [polypeptide binding]; other site 324057009876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009877 DNA binding site [nucleotide binding] 324057009878 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057009879 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057009880 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 324057009881 AMP-binding enzyme; Region: AMP-binding; cl15778 324057009882 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 324057009883 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 324057009884 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057009885 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 324057009886 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 324057009887 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 324057009888 metal binding triad [ion binding]; metal-binding site 324057009889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057009890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057009891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057009892 DNA binding site [nucleotide binding] 324057009893 domain linker motif; other site 324057009894 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057009895 dimerization interface [polypeptide binding]; other site 324057009896 ligand binding site [chemical binding]; other site 324057009897 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057009898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057009900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057009901 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009903 Sulfatase; Region: Sulfatase; cl10460 324057009904 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057009905 Sulfatase; Region: Sulfatase; cl10460 324057009906 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057009907 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 324057009908 N-acetyltransferase; Region: Acetyltransf_2; cl00949 324057009909 Cupin domain; Region: Cupin_2; cl09118 324057009910 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057009911 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057009912 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057009913 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057009914 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057009915 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057009916 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057009917 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057009918 dimer interface [polypeptide binding]; other site 324057009919 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057009920 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 324057009921 Putative glucoamylase; Region: Glycoamylase; pfam10091 324057009922 Putative carbohydrate binding domain; Region: CBM_X; cl05621 324057009923 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 324057009924 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 324057009925 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 324057009926 Putative carbohydrate binding domain; Region: CBM_X; cl05621 324057009927 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 324057009928 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 324057009929 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057009930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057009931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057009932 Helix-turn-helix domains; Region: HTH; cl00088 324057009933 Helix-turn-helix domains; Region: HTH; cl00088 324057009934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009936 putative substrate translocation pore; other site 324057009937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009938 Helix-turn-helix domains; Region: HTH; cl00088 324057009939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009940 dimerization interface [polypeptide binding]; other site 324057009941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057009942 TPR motif; other site 324057009943 TPR repeat; Region: TPR_11; pfam13414 324057009944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057009945 TPR motif; other site 324057009946 binding surface 324057009947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057009948 binding surface 324057009949 TPR motif; other site 324057009950 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057009951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057009952 Walker A motif; other site 324057009953 ATP binding site [chemical binding]; other site 324057009954 Walker B motif; other site 324057009955 arginine finger; other site 324057009956 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 324057009957 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057009958 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057009959 catalytic residue [active] 324057009960 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057009961 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 324057009962 NADP binding site [chemical binding]; other site 324057009963 homodimer interface [polypeptide binding]; other site 324057009964 active site 324057009965 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 324057009966 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 324057009967 active site 324057009968 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324057009969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057009970 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057009971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057009972 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 324057009973 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 324057009974 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 324057009975 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057009976 active site 324057009977 metal binding site [ion binding]; metal-binding site 324057009978 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 324057009979 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057009980 active site 324057009981 metal binding site [ion binding]; metal-binding site 324057009982 homotetramer interface [polypeptide binding]; other site 324057009983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009984 dimerization interface [polypeptide binding]; other site 324057009985 putative DNA binding site [nucleotide binding]; other site 324057009986 putative Zn2+ binding site [ion binding]; other site 324057009987 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057009988 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 324057009989 dimer interface [polypeptide binding]; other site 324057009990 substrate binding site [chemical binding]; other site 324057009991 metal binding site [ion binding]; metal-binding site 324057009992 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 324057009993 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 324057009994 active site 324057009995 purine riboside binding site [chemical binding]; other site 324057009996 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 324057009997 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057009998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057009999 catalytic residue [active] 324057010000 allantoate amidohydrolase; Reviewed; Region: PRK09290 324057010001 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 324057010002 active site 324057010003 metal binding site [ion binding]; metal-binding site 324057010004 dimer interface [polypeptide binding]; other site 324057010005 allantoinase; Provisional; Region: PRK06189 324057010006 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 324057010007 active site 324057010008 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 324057010009 active site 324057010010 homotetramer interface [polypeptide binding]; other site 324057010011 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 324057010012 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 324057010013 active site 324057010014 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 324057010015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 324057010016 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 324057010017 catalytic loop [active] 324057010018 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 324057010019 iron binding site [ion binding]; other site 324057010020 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 324057010021 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 324057010022 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 324057010023 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324057010024 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 324057010025 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 324057010026 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057010027 TM-ABC transporter signature motif; other site 324057010028 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057010029 TM-ABC transporter signature motif; other site 324057010030 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 324057010031 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057010032 Walker A/P-loop; other site 324057010033 ATP binding site [chemical binding]; other site 324057010034 Q-loop/lid; other site 324057010035 ABC transporter signature motif; other site 324057010036 Walker B; other site 324057010037 D-loop; other site 324057010038 H-loop/switch region; other site 324057010039 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057010040 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 324057010041 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 324057010042 putative ligand binding site [chemical binding]; other site 324057010043 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 324057010044 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 324057010045 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 324057010046 XdhC Rossmann domain; Region: XdhC_C; pfam13478 324057010047 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 324057010048 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 324057010049 active site 324057010050 putative substrate binding pocket [chemical binding]; other site 324057010051 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057010052 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 324057010053 Helix-turn-helix domains; Region: HTH; cl00088 324057010054 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057010055 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 324057010056 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057010057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057010059 putative substrate translocation pore; other site 324057010060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010061 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 324057010062 Bacitracin resistance protein BacA; Region: BacA; cl00858 324057010063 Domain of unknown function DUF21; Region: DUF21; pfam01595 324057010064 gliding motility-associated protein GldE; Region: GldE; TIGR03520 324057010065 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324057010066 Transporter associated domain; Region: CorC_HlyC; cl08393 324057010067 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 324057010068 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 324057010069 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 324057010070 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 324057010071 active site 324057010072 dimer interface [polypeptide binding]; other site 324057010073 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 324057010074 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 324057010075 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 324057010076 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 324057010077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057010078 ATP binding site [chemical binding]; other site 324057010079 putative Mg++ binding site [ion binding]; other site 324057010080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057010081 nucleotide binding region [chemical binding]; other site 324057010082 ATP-binding site [chemical binding]; other site 324057010083 Helicase associated domain (HA2); Region: HA2; cl04503 324057010084 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 324057010085 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 324057010086 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 324057010087 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057010088 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 324057010089 active site 324057010090 HIGH motif; other site 324057010091 nucleotide binding site [chemical binding]; other site 324057010092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057010093 active site 324057010094 KMSKS motif; other site 324057010095 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 324057010096 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 324057010097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057010098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057010099 homodimer interface [polypeptide binding]; other site 324057010100 catalytic residue [active] 324057010101 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 324057010102 CobD/Cbib protein; Region: CobD_Cbib; cl00561 324057010103 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 324057010104 homotrimer interface [polypeptide binding]; other site 324057010105 Walker A motif; other site 324057010106 GTP binding site [chemical binding]; other site 324057010107 Walker B motif; other site 324057010108 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 324057010109 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 324057010110 putative dimer interface [polypeptide binding]; other site 324057010111 active site pocket [active] 324057010112 putative cataytic base [active] 324057010113 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057010114 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057010115 Walker A/P-loop; other site 324057010116 ATP binding site [chemical binding]; other site 324057010117 Q-loop/lid; other site 324057010118 ABC transporter signature motif; other site 324057010119 Walker B; other site 324057010120 D-loop; other site 324057010121 H-loop/switch region; other site 324057010122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057010123 ABC-ATPase subunit interface; other site 324057010124 dimer interface [polypeptide binding]; other site 324057010125 putative PBP binding regions; other site 324057010126 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 324057010127 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057010128 putative binding site residues; other site 324057010129 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324057010130 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057010131 metal-binding site [ion binding] 324057010132 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057010133 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057010134 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324057010135 active site residue [active] 324057010136 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 324057010137 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 324057010138 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 324057010139 VanW like protein; Region: VanW; pfam04294 324057010140 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324057010141 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324057010142 Catalytic site [active] 324057010143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057010145 putative substrate translocation pore; other site 324057010146 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 324057010147 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057010148 Walker A/P-loop; other site 324057010149 ATP binding site [chemical binding]; other site 324057010150 Q-loop/lid; other site 324057010151 ABC transporter signature motif; other site 324057010152 Walker B; other site 324057010153 D-loop; other site 324057010154 H-loop/switch region; other site 324057010155 Cobalt transport protein; Region: CbiQ; cl00463 324057010156 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 324057010157 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 324057010158 Walker A/P-loop; other site 324057010159 ATP binding site [chemical binding]; other site 324057010160 Q-loop/lid; other site 324057010161 ABC transporter signature motif; other site 324057010162 Walker B; other site 324057010163 D-loop; other site 324057010164 H-loop/switch region; other site 324057010165 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 324057010166 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 324057010167 putative dimer interface [polypeptide binding]; other site 324057010168 catalytic triad [active] 324057010169 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 324057010170 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 324057010171 dimer interface [polypeptide binding]; other site 324057010172 active site 324057010173 metal binding site [ion binding]; metal-binding site 324057010174 Protein of unknown function (DUF964); Region: DUF964; cl01483 324057010175 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 324057010176 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 324057010177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057010178 FeS/SAM binding site; other site 324057010179 TRAM domain; Region: TRAM; cl01282 324057010180 Propanediol utilisation protein PduL; Region: PduL; pfam06130 324057010181 Propanediol utilisation protein PduL; Region: PduL; pfam06130 324057010182 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 324057010183 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 324057010184 TPP-binding site [chemical binding]; other site 324057010185 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 324057010186 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 324057010187 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 324057010188 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 324057010189 dimer interface [polypeptide binding]; other site 324057010190 PYR/PP interface [polypeptide binding]; other site 324057010191 TPP binding site [chemical binding]; other site 324057010192 substrate binding site [chemical binding]; other site 324057010193 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057010194 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 324057010195 active site 324057010196 dimer interface [polypeptide binding]; other site 324057010197 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 324057010198 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 324057010199 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057010200 putative active site [active] 324057010201 metal binding site [ion binding]; metal-binding site 324057010202 homodimer binding site [polypeptide binding]; other site 324057010203 phosphodiesterase; Provisional; Region: PRK12704 324057010204 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057010205 RecX family; Region: RecX; cl00936 324057010206 recombinase A; Provisional; Region: recA; PRK09354 324057010207 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 324057010208 hexamer interface [polypeptide binding]; other site 324057010209 Walker A motif; other site 324057010210 ATP binding site [chemical binding]; other site 324057010211 Walker B motif; other site 324057010212 competence damage-inducible protein A; Provisional; Region: PRK00549 324057010213 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 324057010214 putative MPT binding site; other site 324057010215 Competence-damaged protein; Region: CinA; cl00666 324057010216 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057010217 Protein of unknown function (DUF520); Region: DUF520; cl00723 324057010218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057010219 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057010220 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 324057010221 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 324057010222 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057010223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010224 NAD(P) binding site [chemical binding]; other site 324057010225 active site 324057010226 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324057010227 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324057010228 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324057010229 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324057010230 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324057010231 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 324057010232 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 324057010233 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057010234 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 324057010235 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 324057010236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010237 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 324057010238 YlzJ-like protein; Region: YlzJ; pfam14035 324057010239 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 324057010240 active site 324057010241 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324057010242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057010243 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324057010244 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 324057010245 dihydrodipicolinate synthase; Region: dapA; TIGR00674 324057010246 dimer interface [polypeptide binding]; other site 324057010247 active site 324057010248 catalytic residue [active] 324057010249 aspartate kinase I; Reviewed; Region: PRK08210 324057010250 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 324057010251 nucleotide binding site [chemical binding]; other site 324057010252 substrate binding site [chemical binding]; other site 324057010253 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 324057010254 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057010255 Flavoprotein; Region: Flavoprotein; cl08021 324057010256 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 324057010257 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 324057010258 trimer interface [polypeptide binding]; other site 324057010259 active site 324057010260 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324057010261 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324057010262 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324057010263 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 324057010264 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 324057010265 NodB motif; other site 324057010266 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 324057010267 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 324057010268 RNase E interface [polypeptide binding]; other site 324057010269 trimer interface [polypeptide binding]; other site 324057010270 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 324057010271 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 324057010272 RNase E interface [polypeptide binding]; other site 324057010273 trimer interface [polypeptide binding]; other site 324057010274 active site 324057010275 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 324057010276 putative nucleic acid binding region [nucleotide binding]; other site 324057010277 G-X-X-G motif; other site 324057010278 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 324057010279 RNA binding site [nucleotide binding]; other site 324057010280 domain interface; other site 324057010281 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 324057010282 16S/18S rRNA binding site [nucleotide binding]; other site 324057010283 S13e-L30e interaction site [polypeptide binding]; other site 324057010284 25S rRNA binding site [nucleotide binding]; other site 324057010285 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 324057010286 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 324057010287 active site 324057010288 Riboflavin kinase; Region: Flavokinase; cl03312 324057010289 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 324057010290 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 324057010291 RNA binding site [nucleotide binding]; other site 324057010292 active site 324057010293 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 324057010294 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 324057010295 DHH family; Region: DHH; pfam01368 324057010296 DHHA1 domain; Region: DHHA1; pfam02272 324057010297 Ribosome-binding factor A; Region: RBFA; cl00542 324057010298 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324057010299 translation initiation factor IF-2; Region: IF-2; TIGR00487 324057010300 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324057010301 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 324057010302 G1 box; other site 324057010303 putative GEF interaction site [polypeptide binding]; other site 324057010304 GTP/Mg2+ binding site [chemical binding]; other site 324057010305 Switch I region; other site 324057010306 G2 box; other site 324057010307 G3 box; other site 324057010308 Switch II region; other site 324057010309 G5 box; other site 324057010310 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 324057010311 Translation-initiation factor 2; Region: IF-2; pfam11987 324057010312 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 324057010313 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 324057010314 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 324057010315 putative RNA binding cleft [nucleotide binding]; other site 324057010316 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 324057010317 NusA N-terminal domain; Region: NusA_N; pfam08529 324057010318 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 324057010319 RNA binding site [nucleotide binding]; other site 324057010320 homodimer interface [polypeptide binding]; other site 324057010321 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 324057010322 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 324057010323 G-X-X-G motif; other site 324057010324 ribosome maturation protein RimP; Reviewed; Region: PRK00092 324057010325 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 324057010326 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 324057010327 Sm1 motif; other site 324057010328 predicted subunit interaction site [polypeptide binding]; other site 324057010329 RNA binding pocket [nucleotide binding]; other site 324057010330 Sm2 motif; other site 324057010331 DNA polymerase III PolC; Validated; Region: polC; PRK00448 324057010332 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 324057010333 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 324057010334 generic binding surface II; other site 324057010335 generic binding surface I; other site 324057010336 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324057010337 active site 324057010338 catalytic site [active] 324057010339 substrate binding site [chemical binding]; other site 324057010340 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 324057010341 prolyl-tRNA synthetase; Provisional; Region: PRK08661 324057010342 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 324057010343 dimer interface [polypeptide binding]; other site 324057010344 motif 1; other site 324057010345 active site 324057010346 motif 2; other site 324057010347 motif 3; other site 324057010348 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 324057010349 anticodon binding site; other site 324057010350 zinc-binding site [ion binding]; other site 324057010351 RIP metalloprotease RseP; Region: TIGR00054 324057010352 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 324057010353 active site 324057010354 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 324057010355 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 324057010356 protein binding site [polypeptide binding]; other site 324057010357 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 324057010358 putative substrate binding region [chemical binding]; other site 324057010359 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 324057010360 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 324057010361 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 324057010362 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 324057010363 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 324057010364 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 324057010365 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 324057010366 catalytic residue [active] 324057010367 putative FPP diphosphate binding site; other site 324057010368 putative FPP binding hydrophobic cleft; other site 324057010369 dimer interface [polypeptide binding]; other site 324057010370 putative IPP diphosphate binding site; other site 324057010371 ribosome recycling factor; Reviewed; Region: frr; PRK00083 324057010372 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 324057010373 hinge region; other site 324057010374 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 324057010375 putative nucleotide binding site [chemical binding]; other site 324057010376 uridine monophosphate binding site [chemical binding]; other site 324057010377 homohexameric interface [polypeptide binding]; other site 324057010378 elongation factor Ts; Reviewed; Region: tsf; PRK12332 324057010379 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 324057010380 Elongation factor TS; Region: EF_TS; pfam00889 324057010381 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 324057010382 rRNA interaction site [nucleotide binding]; other site 324057010383 S8 interaction site; other site 324057010384 putative laminin-1 binding site; other site 324057010385 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 324057010386 Protein of unknown function (DUF342); Region: DUF342; pfam03961 324057010387 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 324057010388 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 324057010389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057010390 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057010391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057010392 DNA binding residues [nucleotide binding] 324057010393 CheD chemotactic sensory transduction; Region: CheD; cl00810 324057010394 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 324057010395 putative CheA interaction surface; other site 324057010396 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 324057010397 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 324057010398 putative binding surface; other site 324057010399 active site 324057010400 P2 response regulator binding domain; Region: P2; pfam07194 324057010401 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 324057010402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010403 ATP binding site [chemical binding]; other site 324057010404 Mg2+ binding site [ion binding]; other site 324057010405 G-X-G motif; other site 324057010406 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 324057010407 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 324057010408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010409 active site 324057010410 phosphorylation site [posttranslational modification] 324057010411 intermolecular recognition site; other site 324057010412 dimerization interface [polypeptide binding]; other site 324057010413 CheB methylesterase; Region: CheB_methylest; pfam01339 324057010414 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 324057010415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010416 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 324057010417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010418 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 324057010419 FHIPEP family; Region: FHIPEP; pfam00771 324057010420 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 324057010421 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 324057010422 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 324057010423 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 324057010424 FliP family; Region: FliP; cl00593 324057010425 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 324057010426 Response regulator receiver domain; Region: Response_reg; pfam00072 324057010427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010428 active site 324057010429 phosphorylation site [posttranslational modification] 324057010430 intermolecular recognition site; other site 324057010431 dimerization interface [polypeptide binding]; other site 324057010432 flagellar motor switch protein; Validated; Region: PRK08119 324057010433 Chemotaxis phosphatase CheX; Region: CheX; cl15816 324057010434 Chemotaxis phosphatase CheX; Region: CheX; cl15816 324057010435 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 324057010436 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 324057010437 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 324057010438 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 324057010439 Flagellar protein (FlbD); Region: FlbD; cl00683 324057010440 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 324057010441 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 324057010442 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 324057010443 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 324057010444 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 324057010445 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 324057010446 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 324057010447 MgtE intracellular N domain; Region: MgtE_N; cl15244 324057010448 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 324057010449 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 324057010450 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 324057010451 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 324057010452 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 324057010453 Walker A motif/ATP binding site; other site 324057010454 Walker B motif; other site 324057010455 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 324057010456 Flagellar assembly protein FliH; Region: FliH; pfam02108 324057010457 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 324057010458 FliG C-terminal domain; Region: FliG_C; pfam01706 324057010459 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 324057010460 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 324057010461 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 324057010462 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 324057010463 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 324057010464 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 324057010465 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 324057010466 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 324057010467 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 324057010468 transcriptional repressor CodY; Validated; Region: PRK04158 324057010469 CodY GAF-like domain; Region: CodY; pfam06018 324057010470 Helix-turn-helix domains; Region: HTH; cl00088 324057010471 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 324057010472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057010474 Walker A motif; other site 324057010475 ATP binding site [chemical binding]; other site 324057010476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010477 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 324057010478 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 324057010479 active site 324057010480 HslU subunit interaction site [polypeptide binding]; other site 324057010481 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 324057010482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010483 DNA topoisomerase I; Validated; Region: PRK05582 324057010484 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 324057010485 active site 324057010486 interdomain interaction site; other site 324057010487 putative metal-binding site [ion binding]; other site 324057010488 nucleotide binding site [chemical binding]; other site 324057010489 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324057010490 domain I; other site 324057010491 DNA binding groove [nucleotide binding] 324057010492 phosphate binding site [ion binding]; other site 324057010493 domain II; other site 324057010494 domain III; other site 324057010495 nucleotide binding site [chemical binding]; other site 324057010496 catalytic site [active] 324057010497 domain IV; other site 324057010498 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324057010499 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324057010500 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 324057010501 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 324057010502 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 324057010503 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 324057010504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010505 CoA-ligase; Region: Ligase_CoA; cl02894 324057010506 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 324057010507 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057010508 CoA-ligase; Region: Ligase_CoA; cl02894 324057010509 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 324057010510 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 324057010511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010512 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 324057010513 Restriction endonuclease; Region: Mrr_cat; cl00516 324057010514 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 324057010515 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 324057010516 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 324057010517 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 324057010518 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057010519 active site 324057010520 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 324057010521 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 324057010522 GTP/Mg2+ binding site [chemical binding]; other site 324057010523 G4 box; other site 324057010524 G5 box; other site 324057010525 G1 box; other site 324057010526 Switch I region; other site 324057010527 G2 box; other site 324057010528 G3 box; other site 324057010529 Switch II region; other site 324057010530 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324057010531 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324057010532 Catalytic site [active] 324057010533 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 324057010534 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 324057010535 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 324057010536 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 324057010537 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 324057010538 RimM N-terminal domain; Region: RimM; pfam01782 324057010539 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 324057010540 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 324057010541 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 324057010542 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 324057010543 signal recognition particle protein; Provisional; Region: PRK10867 324057010544 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 324057010545 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324057010546 P loop; other site 324057010547 GTP binding site [chemical binding]; other site 324057010548 Signal peptide binding domain; Region: SRP_SPB; pfam02978 324057010549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057010550 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 324057010551 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 324057010552 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 324057010553 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324057010554 P loop; other site 324057010555 GTP binding site [chemical binding]; other site 324057010556 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324057010557 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 324057010558 Walker A/P-loop; other site 324057010559 ATP binding site [chemical binding]; other site 324057010560 Q-loop/lid; other site 324057010561 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 324057010562 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 324057010563 ABC transporter signature motif; other site 324057010564 Walker B; other site 324057010565 D-loop; other site 324057010566 H-loop/switch region; other site 324057010567 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 324057010568 dimerization interface [polypeptide binding]; other site 324057010569 active site 324057010570 metal binding site [ion binding]; metal-binding site 324057010571 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 324057010572 dsRNA binding site [nucleotide binding]; other site 324057010573 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324057010574 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324057010575 dimer interface [polypeptide binding]; other site 324057010576 active site 324057010577 Phosphopantetheine attachment site; Region: PP-binding; cl09936 324057010578 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057010579 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 324057010580 NAD(P) binding site [chemical binding]; other site 324057010581 homotetramer interface [polypeptide binding]; other site 324057010582 homodimer interface [polypeptide binding]; other site 324057010583 active site 324057010584 Acyl transferase domain; Region: Acyl_transf_1; cl08282 324057010585 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 324057010586 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 324057010587 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 324057010588 dimer interface [polypeptide binding]; other site 324057010589 active site 324057010590 CoA binding pocket [chemical binding]; other site 324057010591 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 324057010592 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 324057010593 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 324057010594 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 324057010595 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 324057010596 hypothetical protein; Provisional; Region: PRK13670 324057010597 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057010598 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 324057010599 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 324057010600 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 324057010601 Nucleoside recognition; Region: Gate; cl00486 324057010602 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 324057010603 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 324057010604 active site 324057010605 (T/H)XGH motif; other site 324057010606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057010607 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 324057010608 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 324057010609 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324057010610 active site 324057010611 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057010612 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057010613 Walker A/P-loop; other site 324057010614 ATP binding site [chemical binding]; other site 324057010615 Q-loop/lid; other site 324057010616 ABC transporter signature motif; other site 324057010617 Walker B; other site 324057010618 D-loop; other site 324057010619 H-loop/switch region; other site 324057010620 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057010621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057010622 Domain of unknown function DUF77; Region: DUF77; cl00307 324057010623 NMT1-like family; Region: NMT1_2; cl15260 324057010624 NMT1/THI5 like; Region: NMT1; pfam09084 324057010625 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057010626 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324057010627 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324057010628 NADP-binding site; other site 324057010629 homotetramer interface [polypeptide binding]; other site 324057010630 substrate binding site [chemical binding]; other site 324057010631 homodimer interface [polypeptide binding]; other site 324057010632 active site 324057010633 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 324057010634 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 324057010635 Substrate binding site; other site 324057010636 Cupin domain; Region: Cupin_2; cl09118 324057010637 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057010638 Probable Catalytic site; other site 324057010639 metal-binding site 324057010640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057010641 active site 324057010642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057010643 Protein of unknown function (DUF563); Region: DUF563; cl15705 324057010644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057010645 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324057010646 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 324057010647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057010648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057010649 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 324057010650 putative trimer interface [polypeptide binding]; other site 324057010651 putative CoA binding site [chemical binding]; other site 324057010652 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324057010653 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 324057010654 inhibitor-cofactor binding pocket; inhibition site 324057010655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057010656 catalytic residue [active] 324057010657 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324057010658 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324057010659 NADP-binding site; other site 324057010660 homotetramer interface [polypeptide binding]; other site 324057010661 substrate binding site [chemical binding]; other site 324057010662 homodimer interface [polypeptide binding]; other site 324057010663 active site 324057010664 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 324057010665 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 324057010666 active site 324057010667 FMN binding site [chemical binding]; other site 324057010668 substrate binding site [chemical binding]; other site 324057010669 3Fe-4S cluster binding site [ion binding]; other site 324057010670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057010671 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057010672 KduI/IolB family; Region: KduI; cl01508 324057010673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057010674 Helix-turn-helix domains; Region: HTH; cl00088 324057010675 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057010676 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 324057010677 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 324057010678 NADP binding site [chemical binding]; other site 324057010679 homodimer interface [polypeptide binding]; other site 324057010680 active site 324057010681 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 324057010682 Helix-turn-helix domains; Region: HTH; cl00088 324057010683 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 324057010684 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 324057010685 putative Cl- selectivity filter; other site 324057010686 putative pore gating glutamate residue; other site 324057010687 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057010688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010689 dimer interface [polypeptide binding]; other site 324057010690 conserved gate region; other site 324057010691 putative PBP binding loops; other site 324057010692 ABC-ATPase subunit interface; other site 324057010693 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057010694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010695 dimer interface [polypeptide binding]; other site 324057010696 conserved gate region; other site 324057010697 putative PBP binding loops; other site 324057010698 ABC-ATPase subunit interface; other site 324057010699 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057010700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057010701 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057010702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010703 active site 324057010704 phosphorylation site [posttranslational modification] 324057010705 intermolecular recognition site; other site 324057010706 dimerization interface [polypeptide binding]; other site 324057010707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057010709 Histidine kinase; Region: His_kinase; pfam06580 324057010710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010711 ATP binding site [chemical binding]; other site 324057010712 Mg2+ binding site [ion binding]; other site 324057010713 G-X-G motif; other site 324057010714 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 324057010715 N- and C-terminal domain interface [polypeptide binding]; other site 324057010716 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 324057010717 active site 324057010718 catalytic site [active] 324057010719 metal binding site [ion binding]; metal-binding site 324057010720 ATP binding site [chemical binding]; other site 324057010721 carbohydrate binding site [chemical binding]; other site 324057010722 L-rhamnose isomerase; Provisional; Region: PRK01076 324057010723 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 324057010724 short chain dehydrogenase; Validated; Region: PRK08324 324057010725 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057010726 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 324057010727 putative NAD(P) binding site [chemical binding]; other site 324057010728 active site 324057010729 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057010730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010731 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057010732 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057010733 Cupin domain; Region: Cupin_2; cl09118 324057010734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010736 Transcriptional regulator [Transcription]; Region: IclR; COG1414 324057010737 Helix-turn-helix domains; Region: HTH; cl00088 324057010738 Bacterial transcriptional regulator; Region: IclR; pfam01614 324057010739 tyramine oxidase; Provisional; Region: tynA; PRK11504 324057010740 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 324057010741 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 324057010742 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 324057010743 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 324057010744 Nitrogen regulatory protein P-II; Region: P-II; cl00412 324057010745 Nitrogen regulatory protein P-II; Region: P-II; smart00938 324057010746 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 324057010747 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 324057010748 catalytic triad [active] 324057010749 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 324057010750 active site 324057010751 catalytic triad [active] 324057010752 oxyanion hole [active] 324057010753 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 324057010754 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 324057010755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010756 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057010757 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057010758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057010759 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057010760 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057010761 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057010762 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057010763 metal binding site [ion binding]; metal-binding site 324057010764 ligand binding site [chemical binding]; other site 324057010765 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057010766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057010767 Interdomain contacts; other site 324057010768 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057010769 Interdomain contacts; other site 324057010770 Cytokine receptor motif; other site 324057010771 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057010772 S-layer homology domain; Region: SLH; pfam00395 324057010773 S-layer homology domain; Region: SLH; pfam00395 324057010774 S-layer homology domain; Region: SLH; pfam00395 324057010775 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057010776 Spore germination protein; Region: Spore_permease; cl15802 324057010777 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057010778 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057010779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057010780 S-adenosylmethionine binding site [chemical binding]; other site 324057010781 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057010782 alpha-galactosidase; Region: PLN02899 324057010783 Cupin domain; Region: Cupin_2; cl09118 324057010784 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057010785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010786 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324057010787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057010788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057010789 DNA binding residues [nucleotide binding] 324057010790 dimerization interface [polypeptide binding]; other site 324057010791 kelch-like protein; Provisional; Region: PHA03098 324057010792 Galactose oxidase, central domain; Region: Kelch_3; cl02701 324057010793 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057010794 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057010795 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057010796 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057010797 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057010798 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057010799 S-layer homology domain; Region: SLH; pfam00395 324057010800 S-layer homology domain; Region: SLH; pfam00395 324057010801 S-layer homology domain; Region: SLH; pfam00395 324057010802 Cupin domain; Region: Cupin_2; cl09118 324057010803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010806 Family description; Region: VCBS; pfam13517 324057010807 Family description; Region: VCBS; pfam13517 324057010808 Family description; Region: VCBS; pfam13517 324057010809 Family description; Region: VCBS; pfam13517 324057010810 Family description; Region: VCBS; pfam13517 324057010811 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057010812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010813 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057010814 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 324057010815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057010816 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057010817 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 324057010818 putative NAD(P) binding site [chemical binding]; other site 324057010819 catalytic Zn binding site [ion binding]; other site 324057010820 structural Zn binding site [ion binding]; other site 324057010821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057010822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057010823 active site 324057010824 catalytic tetrad [active] 324057010825 Cupin domain; Region: Cupin_2; cl09118 324057010826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010829 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057010830 Cupin domain; Region: Cupin_2; cl09118 324057010831 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057010832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010834 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 324057010835 active site 324057010836 Cupin domain; Region: Cupin_2; cl09118 324057010837 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057010838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010839 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 324057010840 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057010841 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057010842 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057010843 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 324057010844 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057010845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057010846 motif II; other site 324057010847 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 324057010848 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 324057010849 inhibitor site; inhibition site 324057010850 active site 324057010851 dimer interface [polypeptide binding]; other site 324057010852 catalytic residue [active] 324057010853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057010854 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057010855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057010856 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057010857 active site 324057010858 motif I; other site 324057010859 motif II; other site 324057010860 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057010861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057010863 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057010864 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 324057010865 putative NAD(P) binding site [chemical binding]; other site 324057010866 catalytic Zn binding site [ion binding]; other site 324057010867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057010868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057010869 DNA binding site [nucleotide binding] 324057010870 domain linker motif; other site 324057010871 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057010872 dimerization interface [polypeptide binding]; other site 324057010873 ligand binding site [chemical binding]; other site 324057010874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057010875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010876 dimer interface [polypeptide binding]; other site 324057010877 conserved gate region; other site 324057010878 putative PBP binding loops; other site 324057010879 ABC-ATPase subunit interface; other site 324057010880 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057010881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010882 dimer interface [polypeptide binding]; other site 324057010883 conserved gate region; other site 324057010884 putative PBP binding loops; other site 324057010885 ABC-ATPase subunit interface; other site 324057010886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057010887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057010888 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 324057010889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057010890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057010891 homodimer interface [polypeptide binding]; other site 324057010892 catalytic residue [active] 324057010893 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 324057010894 benzoate transporter; Region: benE; TIGR00843 324057010895 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 324057010896 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 324057010897 N- and C-terminal domain interface [polypeptide binding]; other site 324057010898 putative active site [active] 324057010899 catalytic site [active] 324057010900 metal binding site [ion binding]; metal-binding site 324057010901 carbohydrate binding site [chemical binding]; other site 324057010902 ATP binding site [chemical binding]; other site 324057010903 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 324057010904 GntP family permease; Region: GntP_permease; pfam02447 324057010905 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057010906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010907 active site 324057010908 phosphorylation site [posttranslational modification] 324057010909 intermolecular recognition site; other site 324057010910 dimerization interface [polypeptide binding]; other site 324057010911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010912 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057010913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057010914 Histidine kinase; Region: His_kinase; pfam06580 324057010915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057010916 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057010917 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057010918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057010919 dimerization interface [polypeptide binding]; other site 324057010920 putative DNA binding site [nucleotide binding]; other site 324057010921 putative Zn2+ binding site [ion binding]; other site 324057010922 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057010923 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057010924 Spore germination protein; Region: Spore_permease; cl15802 324057010925 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057010926 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057010927 Epoxide hydrolase N terminus; Region: EHN; pfam06441 324057010928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057010929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010931 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057010932 intersubunit interface [polypeptide binding]; other site 324057010933 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057010934 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057010935 intersubunit interface [polypeptide binding]; other site 324057010936 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 324057010937 active site 324057010938 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057010939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010940 dimer interface [polypeptide binding]; other site 324057010941 conserved gate region; other site 324057010942 putative PBP binding loops; other site 324057010943 ABC-ATPase subunit interface; other site 324057010944 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057010945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010946 dimer interface [polypeptide binding]; other site 324057010947 conserved gate region; other site 324057010948 putative PBP binding loops; other site 324057010949 ABC-ATPase subunit interface; other site 324057010950 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057010951 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057010952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010953 active site 324057010954 phosphorylation site [posttranslational modification] 324057010955 intermolecular recognition site; other site 324057010956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057010958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057010959 Histidine kinase; Region: His_kinase; pfam06580 324057010960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010961 ATP binding site [chemical binding]; other site 324057010962 Mg2+ binding site [ion binding]; other site 324057010963 G-X-G motif; other site 324057010964 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057010965 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057010966 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057010967 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057010968 Cupin domain; Region: Cupin_2; cl09118 324057010969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010970 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010972 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057010973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057010974 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057010975 sugar binding site [chemical binding]; other site 324057010976 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057010977 putative metal binding site [ion binding]; other site 324057010978 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057010979 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057010980 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057010981 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057010982 putative metal binding site [ion binding]; other site 324057010983 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057010984 Right handed beta helix region; Region: Beta_helix; pfam13229 324057010985 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057010986 cytosine deaminase; Provisional; Region: PRK05985 324057010987 active site 324057010988 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 324057010989 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 324057010990 Walker A/P-loop; other site 324057010991 ATP binding site [chemical binding]; other site 324057010992 Q-loop/lid; other site 324057010993 ABC transporter signature motif; other site 324057010994 Walker B; other site 324057010995 D-loop; other site 324057010996 H-loop/switch region; other site 324057010997 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324057010998 TM-ABC transporter signature motif; other site 324057010999 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 324057011000 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 324057011001 Walker A/P-loop; other site 324057011002 ATP binding site [chemical binding]; other site 324057011003 Q-loop/lid; other site 324057011004 ABC transporter signature motif; other site 324057011005 Walker B; other site 324057011006 D-loop; other site 324057011007 H-loop/switch region; other site 324057011008 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324057011009 TM-ABC transporter signature motif; other site 324057011010 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 324057011011 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057011012 cytosine deaminase; Provisional; Region: PRK05985 324057011013 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057011014 active site 324057011015 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057011016 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 324057011017 Helix-turn-helix domains; Region: HTH; cl00088 324057011018 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057011019 cobyric acid synthase; Provisional; Region: PRK00784 324057011020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011022 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 324057011023 catalytic triad [active] 324057011024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057011025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011026 Walker A/P-loop; other site 324057011027 ATP binding site [chemical binding]; other site 324057011028 Q-loop/lid; other site 324057011029 ABC transporter signature motif; other site 324057011030 Walker B; other site 324057011031 D-loop; other site 324057011032 H-loop/switch region; other site 324057011033 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057011034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011035 Walker A/P-loop; other site 324057011036 ATP binding site [chemical binding]; other site 324057011037 Q-loop/lid; other site 324057011038 ABC transporter signature motif; other site 324057011039 Walker B; other site 324057011040 D-loop; other site 324057011041 H-loop/switch region; other site 324057011042 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 324057011043 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 324057011044 putative active site [active] 324057011045 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057011046 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057011047 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057011048 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057011049 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057011050 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057011051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011053 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011055 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057011056 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011058 active site 324057011059 phosphorylation site [posttranslational modification] 324057011060 intermolecular recognition site; other site 324057011061 dimerization interface [polypeptide binding]; other site 324057011062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011065 dimerization interface [polypeptide binding]; other site 324057011066 Histidine kinase; Region: His_kinase; pfam06580 324057011067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011068 ATP binding site [chemical binding]; other site 324057011069 Mg2+ binding site [ion binding]; other site 324057011070 G-X-G motif; other site 324057011071 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 324057011072 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 324057011073 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 324057011074 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 324057011075 Propionate catabolism activator; Region: PrpR_N; pfam06506 324057011076 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 324057011077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057011078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011079 Helix-turn-helix domains; Region: HTH; cl00088 324057011080 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057011081 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011083 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057011084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011085 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057011086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057011087 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057011088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011089 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011091 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 324057011092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057011093 active site 324057011094 ATP binding site [chemical binding]; other site 324057011095 substrate binding site [chemical binding]; other site 324057011096 putative metal dependent hydrolase; Provisional; Region: PRK11598 324057011097 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324057011098 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057011099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057011100 Coenzyme A binding pocket [chemical binding]; other site 324057011101 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 324057011102 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324057011103 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011105 dimer interface [polypeptide binding]; other site 324057011106 conserved gate region; other site 324057011107 putative PBP binding loops; other site 324057011108 ABC-ATPase subunit interface; other site 324057011109 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011112 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011114 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057011115 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 324057011116 DNA binding residues [nucleotide binding] 324057011117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011118 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057011119 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 324057011120 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 324057011121 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 324057011122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057011123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057011124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011125 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057011126 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057011127 Metal-binding active site; metal-binding site 324057011128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057011129 DNA-binding site [nucleotide binding]; DNA binding site 324057011130 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057011131 FCD domain; Region: FCD; cl11656 324057011132 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057011133 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057011134 putative DNA binding site [nucleotide binding]; other site 324057011135 dimerization interface [polypeptide binding]; other site 324057011136 putative Zn2+ binding site [ion binding]; other site 324057011137 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057011138 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057011139 inhibitor binding site; inhibition site 324057011140 active site 324057011141 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057011142 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 324057011143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011144 putative substrate translocation pore; other site 324057011145 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057011146 Cupin domain; Region: Cupin_2; cl09118 324057011147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011150 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057011151 dockerin binding interface; other site 324057011152 S-layer homology domain; Region: SLH; pfam00395 324057011153 S-layer homology domain; Region: SLH; pfam00395 324057011154 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057011155 Probable beta-xylosidase; Provisional; Region: PLN03080 324057011156 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057011157 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057011158 metal binding site [ion binding]; metal-binding site 324057011159 ligand binding site [chemical binding]; other site 324057011160 Cadherin repeat-like domain; Region: CA_like; cl15786 324057011161 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057011162 dockerin binding interface; other site 324057011163 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 324057011164 Ca2+ binding site [ion binding]; other site 324057011165 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011167 dimer interface [polypeptide binding]; other site 324057011168 ABC-ATPase subunit interface; other site 324057011169 putative PBP binding loops; other site 324057011170 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011172 dimer interface [polypeptide binding]; other site 324057011173 conserved gate region; other site 324057011174 putative PBP binding loops; other site 324057011175 ABC-ATPase subunit interface; other site 324057011176 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057011179 Histidine kinase; Region: His_kinase; pfam06580 324057011180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011181 ATP binding site [chemical binding]; other site 324057011182 Mg2+ binding site [ion binding]; other site 324057011183 G-X-G motif; other site 324057011184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011185 Response regulator receiver domain; Region: Response_reg; pfam00072 324057011186 active site 324057011187 phosphorylation site [posttranslational modification] 324057011188 intermolecular recognition site; other site 324057011189 dimerization interface [polypeptide binding]; other site 324057011190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011191 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011193 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057011194 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011196 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011198 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011200 active site 324057011201 phosphorylation site [posttranslational modification] 324057011202 intermolecular recognition site; other site 324057011203 dimerization interface [polypeptide binding]; other site 324057011204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057011206 Histidine kinase; Region: His_kinase; pfam06580 324057011207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057011208 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057011209 classical (c) SDRs; Region: SDR_c; cd05233 324057011210 NAD(P) binding site [chemical binding]; other site 324057011211 active site 324057011212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057011213 Helix-turn-helix domains; Region: HTH; cl00088 324057011214 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057011215 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057011216 active site 324057011217 catalytic tetrad [active] 324057011218 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057011219 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057011220 DNA binding residues [nucleotide binding] 324057011221 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 324057011222 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 324057011223 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057011224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011225 putative substrate translocation pore; other site 324057011226 Cupin domain; Region: Cupin_2; cl09118 324057011227 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324057011228 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 324057011229 putative NAD(P) binding site [chemical binding]; other site 324057011230 putative substrate binding site [chemical binding]; other site 324057011231 catalytic Zn binding site [ion binding]; other site 324057011232 structural Zn binding site [ion binding]; other site 324057011233 dimer interface [polypeptide binding]; other site 324057011234 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057011235 Helix-turn-helix domains; Region: HTH; cl00088 324057011236 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 324057011237 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 324057011238 Mg++ binding site [ion binding]; other site 324057011239 putative catalytic motif [active] 324057011240 putative substrate binding site [chemical binding]; other site 324057011241 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011243 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 324057011244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011246 dimer interface [polypeptide binding]; other site 324057011247 conserved gate region; other site 324057011248 ABC-ATPase subunit interface; other site 324057011249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011250 dimer interface [polypeptide binding]; other site 324057011251 conserved gate region; other site 324057011252 putative PBP binding loops; other site 324057011253 ABC-ATPase subunit interface; other site 324057011254 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011256 active site 324057011257 phosphorylation site [posttranslational modification] 324057011258 intermolecular recognition site; other site 324057011259 dimerization interface [polypeptide binding]; other site 324057011260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011263 Cache domain; Region: Cache_1; pfam02743 324057011264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057011265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011266 dimerization interface [polypeptide binding]; other site 324057011267 Histidine kinase; Region: His_kinase; pfam06580 324057011268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011269 ATP binding site [chemical binding]; other site 324057011270 Mg2+ binding site [ion binding]; other site 324057011271 G-X-G motif; other site 324057011272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057011273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057011274 DNA binding site [nucleotide binding] 324057011275 domain linker motif; other site 324057011276 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057011277 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057011278 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057011279 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057011280 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057011281 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057011282 Protein of unknown function (DUF464); Region: DUF464; cl01080 324057011283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057011284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057011285 DNA binding site [nucleotide binding] 324057011286 domain linker motif; other site 324057011287 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057011288 ligand binding site [chemical binding]; other site 324057011289 dimerization interface [polypeptide binding]; other site 324057011290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057011291 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 324057011292 active site 324057011293 motif I; other site 324057011294 motif II; other site 324057011295 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 324057011296 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057011297 Walker A/P-loop; other site 324057011298 ATP binding site [chemical binding]; other site 324057011299 Q-loop/lid; other site 324057011300 ABC transporter signature motif; other site 324057011301 Walker B; other site 324057011302 D-loop; other site 324057011303 H-loop/switch region; other site 324057011304 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057011305 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057011306 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057011307 Walker A/P-loop; other site 324057011308 ATP binding site [chemical binding]; other site 324057011309 Q-loop/lid; other site 324057011310 ABC transporter signature motif; other site 324057011311 Walker B; other site 324057011312 D-loop; other site 324057011313 H-loop/switch region; other site 324057011314 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057011315 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 324057011316 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324057011317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011318 dimer interface [polypeptide binding]; other site 324057011319 conserved gate region; other site 324057011320 putative PBP binding loops; other site 324057011321 ABC-ATPase subunit interface; other site 324057011322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057011323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011324 dimer interface [polypeptide binding]; other site 324057011325 conserved gate region; other site 324057011326 putative PBP binding loops; other site 324057011327 ABC-ATPase subunit interface; other site 324057011328 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 324057011329 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057011330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011332 dimer interface [polypeptide binding]; other site 324057011333 conserved gate region; other site 324057011334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011335 ABC-ATPase subunit interface; other site 324057011336 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011338 dimer interface [polypeptide binding]; other site 324057011339 conserved gate region; other site 324057011340 putative PBP binding loops; other site 324057011341 ABC-ATPase subunit interface; other site 324057011342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011343 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057011344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011345 Response regulator receiver domain; Region: Response_reg; pfam00072 324057011346 active site 324057011347 phosphorylation site [posttranslational modification] 324057011348 intermolecular recognition site; other site 324057011349 dimerization interface [polypeptide binding]; other site 324057011350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011354 dimerization interface [polypeptide binding]; other site 324057011355 Histidine kinase; Region: His_kinase; pfam06580 324057011356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011357 ATP binding site [chemical binding]; other site 324057011358 Mg2+ binding site [ion binding]; other site 324057011359 G-X-G motif; other site 324057011360 EamA-like transporter family; Region: EamA; cl01037 324057011361 EamA-like transporter family; Region: EamA; cl01037 324057011362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057011363 Helix-turn-helix domains; Region: HTH; cl00088 324057011364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057011365 dimerization interface [polypeptide binding]; other site 324057011366 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011368 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011370 dimer interface [polypeptide binding]; other site 324057011371 conserved gate region; other site 324057011372 ABC-ATPase subunit interface; other site 324057011373 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011375 dimer interface [polypeptide binding]; other site 324057011376 conserved gate region; other site 324057011377 ABC-ATPase subunit interface; other site 324057011378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011380 DNA polymerase IV; Reviewed; Region: PRK03103 324057011381 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 324057011382 active site 324057011383 DNA binding site [nucleotide binding] 324057011384 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 324057011385 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 324057011386 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 324057011387 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 324057011388 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 324057011389 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 324057011390 generic binding surface II; other site 324057011391 ssDNA binding site; other site 324057011392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057011393 ATP binding site [chemical binding]; other site 324057011394 putative Mg++ binding site [ion binding]; other site 324057011395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057011396 nucleotide binding region [chemical binding]; other site 324057011397 ATP-binding site [chemical binding]; other site 324057011398 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 324057011399 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 324057011400 DAK2 domain; Region: Dak2; cl03685 324057011401 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 324057011402 Asp23 family; Region: Asp23; cl00574 324057011403 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 324057011404 Stage V sporulation protein family; Region: SpoV; cl15455 324057011405 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 324057011406 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 324057011407 substrate binding site [chemical binding]; other site 324057011408 hexamer interface [polypeptide binding]; other site 324057011409 metal binding site [ion binding]; metal-binding site 324057011410 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 324057011411 GTPase RsgA; Reviewed; Region: PRK00098 324057011412 RNA binding site [nucleotide binding]; other site 324057011413 homodimer interface [polypeptide binding]; other site 324057011414 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 324057011415 GTPase/Zn-binding domain interface [polypeptide binding]; other site 324057011416 GTP/Mg2+ binding site [chemical binding]; other site 324057011417 G4 box; other site 324057011418 G5 box; other site 324057011419 G1 box; other site 324057011420 Switch I region; other site 324057011421 G2 box; other site 324057011422 G3 box; other site 324057011423 Switch II region; other site 324057011424 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057011425 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324057011426 active site 324057011427 ATP binding site [chemical binding]; other site 324057011428 substrate binding site [chemical binding]; other site 324057011429 activation loop (A-loop); other site 324057011430 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324057011431 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324057011432 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324057011433 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324057011434 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 324057011435 active site 324057011436 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 324057011437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057011438 FeS/SAM binding site; other site 324057011439 16S rRNA methyltransferase B; Provisional; Region: PRK14902 324057011440 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 324057011441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057011442 S-adenosylmethionine binding site [chemical binding]; other site 324057011443 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 324057011444 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 324057011445 putative active site [active] 324057011446 substrate binding site [chemical binding]; other site 324057011447 putative cosubstrate binding site; other site 324057011448 catalytic site [active] 324057011449 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 324057011450 substrate binding site [chemical binding]; other site 324057011451 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 324057011452 active site 324057011453 catalytic residues [active] 324057011454 metal binding site [ion binding]; metal-binding site 324057011455 primosome assembly protein PriA; Validated; Region: PRK05580 324057011456 primosome assembly protein PriA; Validated; Region: PRK05580 324057011457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057011458 ATP binding site [chemical binding]; other site 324057011459 putative Mg++ binding site [ion binding]; other site 324057011460 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011461 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 324057011462 Flavoprotein; Region: Flavoprotein; cl08021 324057011463 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 324057011464 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 324057011465 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 324057011466 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 324057011467 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 324057011468 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 324057011469 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057011470 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 324057011471 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 324057011472 Cysteine-rich domain; Region: CCG; pfam02754 324057011473 Cysteine-rich domain; Region: CCG; pfam02754 324057011474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057011475 Helix-turn-helix domains; Region: HTH; cl00088 324057011476 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057011477 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 324057011478 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 324057011479 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 324057011480 catalytic site [active] 324057011481 G-X2-G-X-G-K; other site 324057011482 Domain of unknown function (DUF370); Region: DUF370; cl00898 324057011483 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 324057011484 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 324057011485 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 324057011486 FAD binding site [chemical binding]; other site 324057011487 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 324057011488 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 324057011489 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 324057011490 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 324057011491 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 324057011492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057011493 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324057011494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057011495 motif II; other site 324057011496 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324057011497 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 324057011498 Domain of unknown function (DUF814); Region: DUF814; pfam05670 324057011499 NlpC/P60 family; Region: NLPC_P60; cl11438 324057011500 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324057011501 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 324057011502 Helix-turn-helix domains; Region: HTH; cl00088 324057011503 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 324057011504 putative dimerization interface [polypeptide binding]; other site 324057011505 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 324057011506 Protein of unknown function (DUF964); Region: DUF964; cl01483 324057011507 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 324057011508 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 324057011509 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 324057011510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057011512 ATP binding site [chemical binding]; other site 324057011513 putative Mg++ binding site [ion binding]; other site 324057011514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057011515 nucleotide binding region [chemical binding]; other site 324057011516 ATP-binding site [chemical binding]; other site 324057011517 FOG: CBS domain [General function prediction only]; Region: COG0517 324057011518 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 324057011519 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057011520 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 324057011521 metal binding site [ion binding]; metal-binding site 324057011522 dimer interface [polypeptide binding]; other site 324057011523 YugN-like family; Region: YugN; pfam08868 324057011524 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 324057011525 Asp23 family; Region: Asp23; cl00574 324057011526 calcium/proton exchanger (cax); Region: cax; TIGR00378 324057011527 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 324057011528 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 324057011529 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057011530 regulatory protein interface [polypeptide binding]; other site 324057011531 regulatory phosphorylation site [posttranslational modification]; other site 324057011532 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 324057011533 GAF domain; Region: GAF; cl15785 324057011534 GAF domain; Region: GAF; cl15785 324057011535 GAF domain; Region: GAF_2; pfam13185 324057011536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057011537 metal binding site [ion binding]; metal-binding site 324057011538 active site 324057011539 I-site; other site 324057011540 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 324057011541 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 324057011542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057011543 RNA binding surface [nucleotide binding]; other site 324057011544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057011545 S-adenosylmethionine binding site [chemical binding]; other site 324057011546 hypothetical protein; Provisional; Region: PHA02941 324057011547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 324057011548 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 324057011549 Transglycosylase; Region: Transgly; cl07896 324057011550 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057011551 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057011552 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057011553 Interdomain contacts; other site 324057011554 Cytokine receptor motif; other site 324057011555 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057011556 Interdomain contacts; other site 324057011557 Cytokine receptor motif; other site 324057011558 acetyl-CoA synthetase; Provisional; Region: PRK04319 324057011559 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 324057011560 AMP-binding enzyme; Region: AMP-binding; cl15778 324057011561 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057011562 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057011563 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 324057011564 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 324057011565 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 324057011566 catabolite control protein A; Region: ccpA; TIGR01481 324057011567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057011568 DNA binding site [nucleotide binding] 324057011569 domain linker motif; other site 324057011570 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 324057011571 dimerization interface [polypeptide binding]; other site 324057011572 effector binding site; other site 324057011573 VanZ like family; Region: VanZ; cl01971 324057011574 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 324057011575 proposed catalytic triad [active] 324057011576 conserved cys residue [active] 324057011577 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324057011578 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324057011579 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 324057011580 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 324057011581 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 324057011582 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 324057011583 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324057011584 active site turn [active] 324057011585 phosphorylation site [posttranslational modification] 324057011586 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 324057011587 HPr interaction site; other site 324057011588 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324057011589 active site 324057011590 phosphorylation site [posttranslational modification] 324057011591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011592 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 324057011593 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 324057011594 hinge; other site 324057011595 active site 324057011596 shikimate kinase; Reviewed; Region: aroK; PRK00131 324057011597 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 324057011598 ADP binding site [chemical binding]; other site 324057011599 magnesium binding site [ion binding]; other site 324057011600 putative shikimate binding site; other site 324057011601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011602 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 324057011603 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 324057011604 prolyl-tRNA synthetase; Provisional; Region: PRK09194 324057011605 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 324057011606 dimer interface [polypeptide binding]; other site 324057011607 motif 1; other site 324057011608 active site 324057011609 motif 2; other site 324057011610 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 324057011611 putative deacylase active site [active] 324057011612 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 324057011613 active site 324057011614 motif 3; other site 324057011615 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 324057011616 anticodon binding site; other site 324057011617 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 324057011618 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324057011619 Protein export membrane protein; Region: SecD_SecF; cl14618 324057011620 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 324057011621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011622 Walker A/P-loop; other site 324057011623 ATP binding site [chemical binding]; other site 324057011624 Q-loop/lid; other site 324057011625 ABC transporter signature motif; other site 324057011626 Walker B; other site 324057011627 D-loop; other site 324057011628 H-loop/switch region; other site 324057011629 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057011630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057011631 Helix-turn-helix domains; Region: HTH; cl00088 324057011632 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057011633 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057011634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057011636 putative substrate translocation pore; other site 324057011637 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 324057011638 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 324057011639 homodimer interface [polypeptide binding]; other site 324057011640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057011641 catalytic residue [active] 324057011642 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 324057011643 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 324057011644 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 324057011645 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057011646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057011647 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 324057011648 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 324057011649 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 324057011650 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057011651 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057011652 RNA polymerase sigma factor; Provisional; Region: PRK12519 324057011653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057011654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057011655 DNA binding residues [nucleotide binding] 324057011656 Putative zinc-finger; Region: zf-HC2; cl15806 324057011657 putative anti-sigmaE protein; Provisional; Region: PRK13920 324057011658 Cupin domain; Region: Cupin_2; cl09118 324057011659 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011661 active site 324057011662 phosphorylation site [posttranslational modification] 324057011663 intermolecular recognition site; other site 324057011664 dimerization interface [polypeptide binding]; other site 324057011665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011666 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057011668 Histidine kinase; Region: His_kinase; pfam06580 324057011669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057011670 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011672 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057011673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011674 dimer interface [polypeptide binding]; other site 324057011675 conserved gate region; other site 324057011676 putative PBP binding loops; other site 324057011677 ABC-ATPase subunit interface; other site 324057011678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011679 dimer interface [polypeptide binding]; other site 324057011680 conserved gate region; other site 324057011681 putative PBP binding loops; other site 324057011682 ABC-ATPase subunit interface; other site 324057011683 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057011684 Cation efflux family; Region: Cation_efflux; cl00316 324057011685 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057011686 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057011687 Probable Catalytic site; other site 324057011688 metal-binding site 324057011689 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 324057011690 substrate binding site; other site 324057011691 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 324057011692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011693 NAD(P) binding site [chemical binding]; other site 324057011694 active site 324057011695 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 324057011696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057011697 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 324057011698 Cupin domain; Region: Cupin_2; cl09118 324057011699 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057011700 trimer interface [polypeptide binding]; other site 324057011701 active site 324057011702 substrate binding site [chemical binding]; other site 324057011703 CoA binding site [chemical binding]; other site 324057011704 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 324057011705 extended (e) SDRs; Region: SDR_e; cd08946 324057011706 NAD(P) binding site [chemical binding]; other site 324057011707 active site 324057011708 substrate binding site [chemical binding]; other site 324057011709 PrcB C-terminal; Region: PrcB_C; pfam14343 324057011710 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 324057011711 ligand binding site [chemical binding]; other site 324057011712 active site 324057011713 UGI interface [polypeptide binding]; other site 324057011714 catalytic site [active] 324057011715 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 324057011716 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 324057011717 active site 324057011718 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057011719 hypothetical protein; Provisional; Region: PRK13679 324057011720 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324057011721 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057011723 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057011724 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057011725 Walker A/P-loop; other site 324057011726 ATP binding site [chemical binding]; other site 324057011727 Q-loop/lid; other site 324057011728 ABC transporter signature motif; other site 324057011729 Walker B; other site 324057011730 D-loop; other site 324057011731 H-loop/switch region; other site 324057011732 FtsX-like permease family; Region: FtsX; cl15850 324057011733 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 324057011734 FtsX-like permease family; Region: FtsX; cl15850 324057011735 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057011736 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057011737 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057011738 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057011739 Walker A/P-loop; other site 324057011740 ATP binding site [chemical binding]; other site 324057011741 Q-loop/lid; other site 324057011742 ABC transporter signature motif; other site 324057011743 Walker B; other site 324057011744 D-loop; other site 324057011745 H-loop/switch region; other site 324057011746 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057011747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057011748 dimer interface [polypeptide binding]; other site 324057011749 putative CheW interface [polypeptide binding]; other site 324057011750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057011751 active site 324057011752 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 324057011753 active site 324057011754 dimer interface [polypeptide binding]; other site 324057011755 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 324057011756 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057011757 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057011758 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 324057011759 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057011760 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057011761 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 324057011762 IMP binding site; other site 324057011763 dimer interface [polypeptide binding]; other site 324057011764 interdomain contacts; other site 324057011765 partial ornithine binding site; other site 324057011766 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 324057011767 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 324057011768 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 324057011769 catalytic site [active] 324057011770 subunit interface [polypeptide binding]; other site 324057011771 dihydroorotase; Validated; Region: pyrC; PRK09357 324057011772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057011773 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 324057011774 active site 324057011775 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 324057011776 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324057011777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057011779 active site 324057011780 aminotransferase A; Validated; Region: PRK07683 324057011781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057011782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057011783 homodimer interface [polypeptide binding]; other site 324057011784 catalytic residue [active] 324057011785 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057011786 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 324057011787 metal binding site [ion binding]; metal-binding site 324057011788 putative dimer interface [polypeptide binding]; other site 324057011789 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 324057011790 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 324057011791 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 324057011792 active site 324057011793 trimer interface [polypeptide binding]; other site 324057011794 substrate binding site [chemical binding]; other site 324057011795 CoA binding site [chemical binding]; other site 324057011796 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 324057011797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057011798 RNA binding surface [nucleotide binding]; other site 324057011799 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057011800 active site 324057011801 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 324057011802 lipoprotein signal peptidase; Provisional; Region: PRK14787 324057011803 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 324057011804 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 324057011805 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 324057011806 HIGH motif; other site 324057011807 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 324057011808 active site 324057011809 KMSKS motif; other site 324057011810 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 324057011811 tRNA binding surface [nucleotide binding]; other site 324057011812 anticodon binding site; other site 324057011813 DivIVA protein; Region: DivIVA; pfam05103 324057011814 DivIVA domain; Region: DivI1A_domain; TIGR03544 324057011815 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 324057011816 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 324057011817 YGGT family; Region: YGGT; cl00508 324057011818 Protein of unknown function (DUF552); Region: DUF552; cl00775 324057011819 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 324057011820 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057011821 catalytic residue [active] 324057011822 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 324057011823 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 324057011824 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 324057011825 sporulation sigma factor SigG; Reviewed; Region: PRK08215 324057011826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057011827 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057011828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057011829 DNA binding residues [nucleotide binding] 324057011830 sporulation sigma factor SigE; Reviewed; Region: PRK08301 324057011831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057011832 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057011833 DNA binding residues [nucleotide binding] 324057011834 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 324057011835 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 324057011836 cell division protein FtsZ; Validated; Region: PRK09330 324057011837 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 324057011838 nucleotide binding site [chemical binding]; other site 324057011839 SulA interaction site; other site 324057011840 cell division protein FtsA; Region: ftsA; TIGR01174 324057011841 Cell division protein FtsA; Region: FtsA; cl11496 324057011842 Cell division protein FtsA; Region: FtsA; cl11496 324057011843 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 324057011844 Cell division protein FtsQ; Region: FtsQ; pfam03799 324057011845 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057011846 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057011847 hinge; other site 324057011848 active site 324057011849 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 324057011850 FAD binding domain; Region: FAD_binding_4; pfam01565 324057011851 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 324057011852 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 324057011853 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 324057011854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057011855 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057011856 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 324057011857 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 324057011858 Mg++ binding site [ion binding]; other site 324057011859 putative catalytic motif [active] 324057011860 putative substrate binding site [chemical binding]; other site 324057011861 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324057011862 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 324057011863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057011864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057011865 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 324057011866 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324057011867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057011868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057011869 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 324057011870 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057011871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057011872 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 324057011873 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 324057011874 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057011875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057011876 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 324057011877 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 324057011878 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 324057011879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057011880 cell division protein MraZ; Reviewed; Region: PRK00326 324057011881 MraZ protein; Region: MraZ; pfam02381 324057011882 MraZ protein; Region: MraZ; pfam02381 324057011883 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 324057011884 Arginase family; Region: Arginase; cl00306 324057011885 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 324057011886 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057011887 inhibitor-cofactor binding pocket; inhibition site 324057011888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057011889 catalytic residue [active] 324057011890 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 324057011891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011892 oligomerization interface [polypeptide binding]; other site 324057011893 active site 324057011894 NAD+ binding site [chemical binding]; other site 324057011895 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 324057011896 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 324057011897 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 324057011898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057011899 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 324057011900 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 324057011901 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 324057011902 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 324057011903 Uncharacterized conserved protein [Function unknown]; Region: COG1565 324057011904 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 324057011905 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 324057011906 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 324057011907 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011908 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 324057011909 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 324057011910 putative active site [active] 324057011911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057011912 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 324057011913 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057011914 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324057011915 YlaH-like protein; Region: YlaH; pfam14036 324057011916 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 324057011917 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 324057011918 putative GEF interaction site [polypeptide binding]; other site 324057011919 G1 box; other site 324057011920 GTP/Mg2+ binding site [chemical binding]; other site 324057011921 Switch I region; other site 324057011922 G2 box; other site 324057011923 G3 box; other site 324057011924 Switch II region; other site 324057011925 G4 box; other site 324057011926 G5 box; other site 324057011927 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 324057011928 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 324057011929 Integral membrane protein TerC family; Region: TerC; cl10468 324057011930 Integral membrane protein TerC family; Region: TerC; cl10468 324057011931 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 324057011932 THUMP domain; Region: THUMP; cl12076 324057011933 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 324057011934 Ligand Binding Site [chemical binding]; other site 324057011935 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057011936 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 324057011937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057011938 catalytic residue [active] 324057011939 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 324057011940 N-acetyl-D-glucosamine binding site [chemical binding]; other site 324057011941 catalytic residue [active] 324057011942 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 324057011943 dimer interface [polypeptide binding]; other site 324057011944 FMN binding site [chemical binding]; other site 324057011945 UbiA prenyltransferase family; Region: UbiA; cl00337 324057011946 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057011947 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057011948 Walker A/P-loop; other site 324057011949 ATP binding site [chemical binding]; other site 324057011950 Q-loop/lid; other site 324057011951 ABC transporter signature motif; other site 324057011952 Walker B; other site 324057011953 D-loop; other site 324057011954 H-loop/switch region; other site 324057011955 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057011956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057011957 DNA-binding site [nucleotide binding]; DNA binding site 324057011958 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057011959 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057011960 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 324057011961 Walker A/P-loop; other site 324057011962 ATP binding site [chemical binding]; other site 324057011963 Q-loop/lid; other site 324057011964 ABC transporter signature motif; other site 324057011965 Walker B; other site 324057011966 D-loop; other site 324057011967 H-loop/switch region; other site 324057011968 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057011969 dimer interface [polypeptide binding]; other site 324057011970 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 324057011971 putative CheW interface [polypeptide binding]; other site 324057011972 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 324057011973 aminotransferase; Validated; Region: PRK07678 324057011974 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057011975 inhibitor-cofactor binding pocket; inhibition site 324057011976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057011977 catalytic residue [active] 324057011978 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 324057011979 nucleotide binding site/active site [active] 324057011980 HIT family signature motif; other site 324057011981 catalytic residue [active] 324057011982 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057011983 nudix motif; other site 324057011984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057011985 S-adenosylmethionine binding site [chemical binding]; other site 324057011986 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 324057011987 FAD binding domain; Region: FAD_binding_4; pfam01565 324057011988 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 324057011989 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 324057011990 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057011991 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057011992 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057011993 putative metal binding site [ion binding]; other site 324057011994 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057011995 putative metal binding site [ion binding]; other site 324057011996 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057011997 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057011998 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057011999 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 324057012000 Protein of unknown function (DUF541); Region: SIMPL; cl01077 324057012001 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057012002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012003 DNA-binding site [nucleotide binding]; DNA binding site 324057012004 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 324057012005 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057012006 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057012007 Walker A/P-loop; other site 324057012008 ATP binding site [chemical binding]; other site 324057012009 Q-loop/lid; other site 324057012010 ABC transporter signature motif; other site 324057012011 Walker B; other site 324057012012 D-loop; other site 324057012013 H-loop/switch region; other site 324057012014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012016 dimer interface [polypeptide binding]; other site 324057012017 conserved gate region; other site 324057012018 putative PBP binding loops; other site 324057012019 ABC-ATPase subunit interface; other site 324057012020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012021 dimer interface [polypeptide binding]; other site 324057012022 conserved gate region; other site 324057012023 putative PBP binding loops; other site 324057012024 ABC-ATPase subunit interface; other site 324057012025 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324057012026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012027 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 324057012028 Protein of unknown function; Region: DUF3658; pfam12395 324057012029 Cupin domain; Region: Cupin_2; cl09118 324057012030 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057012031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012033 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 324057012034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057012035 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057012036 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 324057012037 Walker A/P-loop; other site 324057012038 ATP binding site [chemical binding]; other site 324057012039 Q-loop/lid; other site 324057012040 ABC transporter signature motif; other site 324057012041 Walker B; other site 324057012042 D-loop; other site 324057012043 H-loop/switch region; other site 324057012044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057012045 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057012046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057012047 Walker A/P-loop; other site 324057012048 ATP binding site [chemical binding]; other site 324057012049 Q-loop/lid; other site 324057012050 ABC transporter signature motif; other site 324057012051 Walker B; other site 324057012052 D-loop; other site 324057012053 H-loop/switch region; other site 324057012054 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057012055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057012056 Walker A/P-loop; other site 324057012057 ATP binding site [chemical binding]; other site 324057012058 Q-loop/lid; other site 324057012059 ABC transporter signature motif; other site 324057012060 Walker B; other site 324057012061 D-loop; other site 324057012062 H-loop/switch region; other site 324057012063 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057012064 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057012065 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057012066 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057012067 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057012068 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057012069 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 324057012070 Walker A/P-loop; other site 324057012071 ATP binding site [chemical binding]; other site 324057012072 Q-loop/lid; other site 324057012073 ABC transporter signature motif; other site 324057012074 Walker B; other site 324057012075 D-loop; other site 324057012076 H-loop/switch region; other site 324057012077 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 324057012078 EamA-like transporter family; Region: EamA; cl01037 324057012079 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057012080 EamA-like transporter family; Region: EamA; cl01037 324057012081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057012082 Helix-turn-helix domains; Region: HTH; cl00088 324057012083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057012084 dimerization interface [polypeptide binding]; other site 324057012085 Cupin domain; Region: Cupin_2; cl09118 324057012086 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057012087 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057012088 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057012089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012090 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057012091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057012092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057012093 non-specific DNA binding site [nucleotide binding]; other site 324057012094 salt bridge; other site 324057012095 sequence-specific DNA binding site [nucleotide binding]; other site 324057012096 Cupin domain; Region: Cupin_2; cl09118 324057012097 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057012098 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057012099 DNA binding residues [nucleotide binding] 324057012100 putative dimer interface [polypeptide binding]; other site 324057012101 oxidoreductase; Provisional; Region: PRK06196 324057012102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012103 NAD(P) binding site [chemical binding]; other site 324057012104 active site 324057012105 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057012106 DinB superfamily; Region: DinB_2; pfam12867 324057012107 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057012108 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 324057012109 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 324057012110 potential catalytic triad [active] 324057012111 conserved cys residue [active] 324057012112 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 324057012113 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 324057012114 ligand binding site [chemical binding]; other site 324057012115 dimerization interface [polypeptide binding]; other site 324057012116 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057012117 TM-ABC transporter signature motif; other site 324057012118 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057012119 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057012120 Walker A/P-loop; other site 324057012121 ATP binding site [chemical binding]; other site 324057012122 Q-loop/lid; other site 324057012123 ABC transporter signature motif; other site 324057012124 Walker B; other site 324057012125 D-loop; other site 324057012126 H-loop/switch region; other site 324057012127 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057012128 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 324057012129 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057012130 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 324057012131 substrate binding site [chemical binding]; other site 324057012132 dimer interface [polypeptide binding]; other site 324057012133 ATP binding site [chemical binding]; other site 324057012134 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057012135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057012136 DNA binding site [nucleotide binding] 324057012137 domain linker motif; other site 324057012138 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057012139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057012140 Helix-turn-helix domains; Region: HTH; cl00088 324057012141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057012142 dimerization interface [polypeptide binding]; other site 324057012143 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 324057012144 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 324057012145 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 324057012146 active site 324057012147 dimer interface [polypeptide binding]; other site 324057012148 effector binding site; other site 324057012149 TSCPD domain; Region: TSCPD; cl14834 324057012150 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057012151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057012152 ATP binding site [chemical binding]; other site 324057012153 putative Mg++ binding site [ion binding]; other site 324057012154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057012155 nucleotide binding region [chemical binding]; other site 324057012156 ATP-binding site [chemical binding]; other site 324057012157 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 324057012158 YqzE-like protein; Region: YqzE; pfam14038 324057012159 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 324057012160 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057012161 active site 324057012162 metal binding site [ion binding]; metal-binding site 324057012163 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 324057012164 NodB motif; other site 324057012165 putative active site [active] 324057012166 putative catalytic site [active] 324057012167 Zn binding site [ion binding]; other site 324057012168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057012169 active site 324057012170 Uncharacterized membrane protein [Function unknown]; Region: COG3949 324057012171 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324057012172 Uncharacterized conserved protein [Function unknown]; Region: COG4717 324057012173 Uncharacterized conserved protein [Function unknown]; Region: COG4717 324057012174 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 324057012175 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057012176 active site 324057012177 metal binding site [ion binding]; metal-binding site 324057012178 DNA binding site [nucleotide binding] 324057012179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057012180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057012181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057012182 metal binding site [ion binding]; metal-binding site 324057012183 active site 324057012184 I-site; other site 324057012185 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057012186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012187 motif II; other site 324057012188 dUMP phosphatase; Provisional; Region: PRK09449 324057012189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012190 motif II; other site 324057012191 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 324057012192 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057012193 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 324057012194 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 324057012195 dimer interface [polypeptide binding]; other site 324057012196 putative radical transfer pathway; other site 324057012197 diiron center [ion binding]; other site 324057012198 tyrosyl radical; other site 324057012199 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 324057012200 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 324057012201 Class I ribonucleotide reductase; Region: RNR_I; cd01679 324057012202 active site 324057012203 dimer interface [polypeptide binding]; other site 324057012204 catalytic residues [active] 324057012205 effector binding site; other site 324057012206 R2 peptide binding site; other site 324057012207 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057012208 thymidine kinase; Provisional; Region: PRK04296 324057012209 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057012210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012211 S-adenosylmethionine binding site [chemical binding]; other site 324057012212 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 324057012213 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057012214 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057012215 Oligomerisation domain; Region: Oligomerisation; cl00519 324057012216 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 324057012217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057012218 Zn2+ binding site [ion binding]; other site 324057012219 Mg2+ binding site [ion binding]; other site 324057012220 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 324057012221 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 324057012222 active site 324057012223 (T/H)XGH motif; other site 324057012224 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 324057012225 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 324057012226 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 324057012227 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 324057012228 shikimate binding site; other site 324057012229 NAD(P) binding site [chemical binding]; other site 324057012230 GTPase YqeH; Provisional; Region: PRK13796 324057012231 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 324057012232 GTP/Mg2+ binding site [chemical binding]; other site 324057012233 G4 box; other site 324057012234 G5 box; other site 324057012235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057012236 G1 box; other site 324057012237 G1 box; other site 324057012238 GTP/Mg2+ binding site [chemical binding]; other site 324057012239 Switch I region; other site 324057012240 G2 box; other site 324057012241 G2 box; other site 324057012242 Switch I region; other site 324057012243 G3 box; other site 324057012244 G3 box; other site 324057012245 Switch II region; other site 324057012246 Switch II region; other site 324057012247 G5 box; other site 324057012248 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 324057012249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012250 active site 324057012251 motif I; other site 324057012252 motif II; other site 324057012253 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 324057012254 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057012255 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324057012256 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324057012257 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057012258 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057012259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057012260 Walker A motif; other site 324057012261 ATP binding site [chemical binding]; other site 324057012262 Walker B motif; other site 324057012263 arginine finger; other site 324057012264 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 324057012265 Uncharacterized conserved protein [Function unknown]; Region: COG2898 324057012266 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 324057012267 SpoVA protein; Region: SpoVA; cl04298 324057012268 stage V sporulation protein AD; Provisional; Region: PRK12404 324057012269 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 324057012270 SpoVA protein; Region: SpoVA; cl04298 324057012271 SpoVA protein; Region: SpoVA; cl04298 324057012272 stage V sporulation protein AD; Provisional; Region: PRK12404 324057012273 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 324057012274 SpoVA protein; Region: SpoVA; cl04298 324057012275 Protein of unknown function (DUF421); Region: DUF421; cl00990 324057012276 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 324057012277 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 324057012278 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 324057012279 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057012280 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 324057012281 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057012282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012283 active site 324057012284 phosphorylation site [posttranslational modification] 324057012285 intermolecular recognition site; other site 324057012286 dimerization interface [polypeptide binding]; other site 324057012287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012289 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057012290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057012291 dimerization interface [polypeptide binding]; other site 324057012292 Histidine kinase; Region: His_kinase; pfam06580 324057012293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057012294 ATP binding site [chemical binding]; other site 324057012295 Mg2+ binding site [ion binding]; other site 324057012296 G-X-G motif; other site 324057012297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012301 dimer interface [polypeptide binding]; other site 324057012302 conserved gate region; other site 324057012303 putative PBP binding loops; other site 324057012304 ABC-ATPase subunit interface; other site 324057012305 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057012306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012307 dimer interface [polypeptide binding]; other site 324057012308 conserved gate region; other site 324057012309 putative PBP binding loops; other site 324057012310 ABC-ATPase subunit interface; other site 324057012311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 324057012312 Putative cyclase; Region: Cyclase; cl00814 324057012313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012315 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057012316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057012317 Coenzyme A binding pocket [chemical binding]; other site 324057012318 hypothetical protein; Validated; Region: PRK06769 324057012319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012320 active site 324057012321 motif I; other site 324057012322 motif II; other site 324057012323 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057012324 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324057012325 nucleoside/Zn binding site; other site 324057012326 dimer interface [polypeptide binding]; other site 324057012327 catalytic motif [active] 324057012328 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 324057012329 MgtC family; Region: MgtC; pfam02308 324057012330 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012331 putative metal binding site [ion binding]; other site 324057012332 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012333 putative metal binding site [ion binding]; other site 324057012334 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057012335 Right handed beta helix region; Region: Beta_helix; pfam13229 324057012336 S-layer homology domain; Region: SLH; pfam00395 324057012337 S-layer homology domain; Region: SLH; pfam00395 324057012338 S-layer homology domain; Region: SLH; pfam00395 324057012339 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057012340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057012341 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057012342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012343 active site 324057012344 phosphorylation site [posttranslational modification] 324057012345 intermolecular recognition site; other site 324057012346 dimerization interface [polypeptide binding]; other site 324057012347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057012350 dimerization interface [polypeptide binding]; other site 324057012351 Histidine kinase; Region: His_kinase; pfam06580 324057012352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057012353 ATP binding site [chemical binding]; other site 324057012354 Mg2+ binding site [ion binding]; other site 324057012355 G-X-G motif; other site 324057012356 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012358 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057012359 active site 324057012360 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012361 putative metal binding site [ion binding]; other site 324057012362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012363 dimer interface [polypeptide binding]; other site 324057012364 conserved gate region; other site 324057012365 putative PBP binding loops; other site 324057012366 ABC-ATPase subunit interface; other site 324057012367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012368 dimer interface [polypeptide binding]; other site 324057012369 conserved gate region; other site 324057012370 putative PBP binding loops; other site 324057012371 ABC-ATPase subunit interface; other site 324057012372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012374 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057012375 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057012376 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057012377 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057012378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057012379 dimerization interface [polypeptide binding]; other site 324057012380 putative DNA binding site [nucleotide binding]; other site 324057012381 putative Zn2+ binding site [ion binding]; other site 324057012382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057012383 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057012384 active site 324057012385 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057012386 putative metal binding site [ion binding]; other site 324057012387 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 324057012388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012389 DNA-binding site [nucleotide binding]; DNA binding site 324057012390 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057012391 dimerization interface [polypeptide binding]; other site 324057012392 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 324057012393 ligand binding site [chemical binding]; other site 324057012394 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 324057012395 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057012396 active site 324057012397 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057012398 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057012399 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057012400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012401 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057012402 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012404 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057012405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012407 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012408 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057012409 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057012410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012411 active site 324057012412 phosphorylation site [posttranslational modification] 324057012413 intermolecular recognition site; other site 324057012414 dimerization interface [polypeptide binding]; other site 324057012415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057012417 Histidine kinase; Region: His_kinase; pfam06580 324057012418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057012419 ATP binding site [chemical binding]; other site 324057012420 Mg2+ binding site [ion binding]; other site 324057012421 G-X-G motif; other site 324057012422 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 324057012423 MFS/sugar transport protein; Region: MFS_2; pfam13347 324057012424 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057012425 beta-D-glucuronidase; Provisional; Region: PRK10150 324057012426 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057012427 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057012428 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 324057012429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057012432 Helix-turn-helix domains; Region: HTH; cl00088 324057012433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057012434 dimerization interface [polypeptide binding]; other site 324057012435 putative uracil/xanthine transporter; Provisional; Region: PRK11412 324057012436 IDEAL domain; Region: IDEAL; cl07452 324057012437 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 324057012438 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057012439 PYR/PP interface [polypeptide binding]; other site 324057012440 dimer interface [polypeptide binding]; other site 324057012441 TPP binding site [chemical binding]; other site 324057012442 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 324057012443 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324057012444 TPP-binding site [chemical binding]; other site 324057012445 dimer interface [polypeptide binding]; other site 324057012446 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 324057012447 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057012448 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057012449 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057012450 Proline dehydrogenase; Region: Pro_dh; cl03282 324057012451 Cupin domain; Region: Cupin_2; cl09118 324057012452 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057012453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012454 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057012455 Interdomain contacts; other site 324057012456 Cytokine receptor motif; other site 324057012457 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057012458 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 324057012459 active site 324057012460 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057012461 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057012462 S-layer homology domain; Region: SLH; pfam00395 324057012463 S-layer homology domain; Region: SLH; pfam00395 324057012464 S-layer homology domain; Region: SLH; pfam00395 324057012465 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057012466 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 324057012467 active site 324057012468 catalytic triad [active] 324057012469 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057012470 Family description; Region: VCBS; pfam13517 324057012471 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 324057012472 putative active site [active] 324057012473 putative metal binding site [ion binding]; other site 324057012474 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 324057012475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012480 dimer interface [polypeptide binding]; other site 324057012481 conserved gate region; other site 324057012482 putative PBP binding loops; other site 324057012483 ABC-ATPase subunit interface; other site 324057012484 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057012485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012486 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057012487 alpha-galactosidase; Region: PLN02229 324057012488 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057012489 catalytic site [active] 324057012490 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 324057012491 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 324057012492 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 324057012493 S-layer homology domain; Region: SLH; pfam00395 324057012494 S-layer homology domain; Region: SLH; pfam00395 324057012495 S-layer homology domain; Region: SLH; pfam00395 324057012496 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 324057012497 substrate binding site [chemical binding]; other site 324057012498 active site 324057012499 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 324057012500 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012502 dimer interface [polypeptide binding]; other site 324057012503 conserved gate region; other site 324057012504 ABC-ATPase subunit interface; other site 324057012505 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057012506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012507 dimer interface [polypeptide binding]; other site 324057012508 conserved gate region; other site 324057012509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012510 ABC-ATPase subunit interface; other site 324057012511 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057012512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012513 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 324057012514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012516 Spore germination protein; Region: Spore_permease; cl15802 324057012517 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057012518 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057012519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057012520 Helix-turn-helix domains; Region: HTH; cl00088 324057012521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057012522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057012523 putative substrate translocation pore; other site 324057012524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057012525 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057012526 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057012527 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057012528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057012529 DNA binding site [nucleotide binding] 324057012530 domain linker motif; other site 324057012531 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057012532 dimerization interface [polypeptide binding]; other site 324057012533 ligand binding site [chemical binding]; other site 324057012534 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057012535 beta-galactosidase; Provisional; Region: PLN03059 324057012536 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057012537 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 324057012538 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057012539 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057012540 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057012541 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057012542 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057012543 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 324057012544 VanZ like family; Region: VanZ; cl01971 324057012545 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012546 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057012547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057012548 Histidine kinase; Region: His_kinase; pfam06580 324057012549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057012550 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057012551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012552 active site 324057012553 phosphorylation site [posttranslational modification] 324057012554 intermolecular recognition site; other site 324057012555 dimerization interface [polypeptide binding]; other site 324057012556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012557 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 324057012558 active site 324057012559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012560 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012562 conserved gate region; other site 324057012563 putative PBP binding loops; other site 324057012564 ABC-ATPase subunit interface; other site 324057012565 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057012566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012567 dimer interface [polypeptide binding]; other site 324057012568 conserved gate region; other site 324057012569 putative PBP binding loops; other site 324057012570 ABC-ATPase subunit interface; other site 324057012571 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057012572 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 324057012573 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 324057012574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057012575 active site 324057012576 HIGH motif; other site 324057012577 nucleotide binding site [chemical binding]; other site 324057012578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057012579 active site 324057012580 KMSKS motif; other site 324057012581 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 324057012582 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057012583 active site 324057012584 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 324057012585 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 324057012586 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057012587 dimer interface [polypeptide binding]; other site 324057012588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057012589 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 324057012590 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 324057012591 active site residue [active] 324057012592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057012593 selenophosphate synthetase; Provisional; Region: PRK00943 324057012594 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 324057012595 dimerization interface [polypeptide binding]; other site 324057012596 putative ATP binding site [chemical binding]; other site 324057012597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057012598 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057012599 Sulfatase; Region: Sulfatase; cl10460 324057012600 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057012601 Sulfatase; Region: Sulfatase; cl10460 324057012602 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057012603 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057012604 Walker A/P-loop; other site 324057012605 ATP binding site [chemical binding]; other site 324057012606 Q-loop/lid; other site 324057012607 ABC transporter signature motif; other site 324057012608 Walker B; other site 324057012609 D-loop; other site 324057012610 H-loop/switch region; other site 324057012611 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057012612 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057012613 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057012614 Walker A/P-loop; other site 324057012615 ATP binding site [chemical binding]; other site 324057012616 Q-loop/lid; other site 324057012617 ABC transporter signature motif; other site 324057012618 Walker B; other site 324057012619 D-loop; other site 324057012620 H-loop/switch region; other site 324057012621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057012622 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057012623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012624 dimer interface [polypeptide binding]; other site 324057012625 conserved gate region; other site 324057012626 putative PBP binding loops; other site 324057012627 ABC-ATPase subunit interface; other site 324057012628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057012629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012630 dimer interface [polypeptide binding]; other site 324057012631 conserved gate region; other site 324057012632 putative PBP binding loops; other site 324057012633 ABC-ATPase subunit interface; other site 324057012634 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 324057012635 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057012636 substrate binding site [chemical binding]; other site 324057012637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057012638 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012640 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057012641 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057012642 Interdomain contacts; other site 324057012643 Cytokine receptor motif; other site 324057012644 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 324057012645 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057012646 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057012647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012648 NAD(P) binding site [chemical binding]; other site 324057012649 active site 324057012650 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057012651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012652 S-adenosylmethionine binding site [chemical binding]; other site 324057012653 BNR repeat-like domain; Region: BNR_2; pfam13088 324057012654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057012655 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057012656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057012657 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057012658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012659 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 324057012660 NAD(P) binding site [chemical binding]; other site 324057012661 active site 324057012662 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 324057012663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012664 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057012665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057012667 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057012668 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057012669 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057012670 DNA binding residues [nucleotide binding] 324057012671 putative dimer interface [polypeptide binding]; other site 324057012672 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324057012673 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 324057012674 putative NAD(P) binding site [chemical binding]; other site 324057012675 putative substrate binding site [chemical binding]; other site 324057012676 catalytic Zn binding site [ion binding]; other site 324057012677 structural Zn binding site [ion binding]; other site 324057012678 dimer interface [polypeptide binding]; other site 324057012679 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057012680 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 324057012681 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057012682 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 324057012683 Cupin domain; Region: Cupin_2; cl09118 324057012684 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057012685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012686 Cupin domain; Region: Cupin_2; cl09118 324057012687 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057012688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012689 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057012690 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057012691 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057012692 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 324057012693 Right handed beta helix region; Region: Beta_helix; pfam13229 324057012694 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057012695 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057012696 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 324057012697 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057012698 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 324057012699 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057012700 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012702 ABC-ATPase subunit interface; other site 324057012703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012706 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012708 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 324057012709 Cupin domain; Region: Cupin_2; cl09118 324057012710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012711 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012713 Cupin domain; Region: Cupin_2; cl09118 324057012714 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 324057012715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012716 LysE type translocator; Region: LysE; cl00565 324057012717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057012718 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057012719 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057012720 sugar binding site [chemical binding]; other site 324057012721 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057012722 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 324057012723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012724 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012727 dimer interface [polypeptide binding]; other site 324057012728 conserved gate region; other site 324057012729 putative PBP binding loops; other site 324057012730 ABC-ATPase subunit interface; other site 324057012731 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057012732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012733 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 324057012734 Cupin domain; Region: Cupin_2; cl09118 324057012735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012736 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 324057012737 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 324057012738 active site 324057012739 catalytic triad [active] 324057012740 oxyanion hole [active] 324057012741 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057012742 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 324057012743 active site 324057012744 catalytic site [active] 324057012745 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057012746 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057012747 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057012748 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057012749 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 324057012750 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 324057012751 putative substrate binding site [chemical binding]; other site 324057012752 active site 324057012753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012754 DNA-binding site [nucleotide binding]; DNA binding site 324057012755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057012756 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057012757 dimerization interface [polypeptide binding]; other site 324057012758 ligand binding site [chemical binding]; other site 324057012759 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057012760 Spore germination protein; Region: Spore_permease; cl15802 324057012761 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057012762 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 324057012763 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057012764 intersubunit interface [polypeptide binding]; other site 324057012765 active site 324057012766 Zn2+ binding site [ion binding]; other site 324057012767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012768 DNA-binding site [nucleotide binding]; DNA binding site 324057012769 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 324057012770 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 324057012771 putative dimerization interface [polypeptide binding]; other site 324057012772 putative ligand binding site [chemical binding]; other site 324057012773 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 324057012774 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 324057012775 putative N- and C-terminal domain interface [polypeptide binding]; other site 324057012776 putative active site [active] 324057012777 putative MgATP binding site [chemical binding]; other site 324057012778 catalytic site [active] 324057012779 metal binding site [ion binding]; metal-binding site 324057012780 putative carbohydrate binding site [chemical binding]; other site 324057012781 Cation efflux family; Region: Cation_efflux; cl00316 324057012782 Protein of unknown function (DUF421); Region: DUF421; cl00990 324057012783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012785 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012787 dimer interface [polypeptide binding]; other site 324057012788 conserved gate region; other site 324057012789 putative PBP binding loops; other site 324057012790 ABC-ATPase subunit interface; other site 324057012791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012792 dimer interface [polypeptide binding]; other site 324057012793 conserved gate region; other site 324057012794 putative PBP binding loops; other site 324057012795 ABC-ATPase subunit interface; other site 324057012796 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 324057012797 mannonate dehydratase; Region: uxuA; TIGR00695 324057012798 mannonate dehydratase; Region: uxuA; TIGR00695 324057012799 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012802 DNA-binding site [nucleotide binding]; DNA binding site 324057012803 FCD domain; Region: FCD; cl11656 324057012804 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057012805 classical (c) SDRs; Region: SDR_c; cd05233 324057012806 NAD(P) binding site [chemical binding]; other site 324057012807 active site 324057012808 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057012809 classical (c) SDRs; Region: SDR_c; cd05233 324057012810 NAD(P) binding site [chemical binding]; other site 324057012811 active site 324057012812 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057012813 metal binding site [ion binding]; metal-binding site 324057012814 substrate binding pocket [chemical binding]; other site 324057012815 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 324057012816 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057012817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057012818 active site 324057012819 catalytic tetrad [active] 324057012820 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012822 dimer interface [polypeptide binding]; other site 324057012823 conserved gate region; other site 324057012824 putative PBP binding loops; other site 324057012825 ABC-ATPase subunit interface; other site 324057012826 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057012827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012828 dimer interface [polypeptide binding]; other site 324057012829 conserved gate region; other site 324057012830 ABC-ATPase subunit interface; other site 324057012831 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012834 active site 324057012835 phosphorylation site [posttranslational modification] 324057012836 intermolecular recognition site; other site 324057012837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012838 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057012841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057012842 dimerization interface [polypeptide binding]; other site 324057012843 Histidine kinase; Region: His_kinase; pfam06580 324057012844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057012845 ATP binding site [chemical binding]; other site 324057012846 Mg2+ binding site [ion binding]; other site 324057012847 G-X-G motif; other site 324057012848 Predicted permeases [General function prediction only]; Region: RarD; COG2962 324057012849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057012850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012851 active site 324057012852 phosphorylation site [posttranslational modification] 324057012853 intermolecular recognition site; other site 324057012854 dimerization interface [polypeptide binding]; other site 324057012855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057012856 DNA binding residues [nucleotide binding] 324057012857 dimerization interface [polypeptide binding]; other site 324057012858 Histidine kinase; Region: HisKA_3; pfam07730 324057012859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057012860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057012861 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 324057012862 Walker A/P-loop; other site 324057012863 ATP binding site [chemical binding]; other site 324057012864 Q-loop/lid; other site 324057012865 ABC transporter signature motif; other site 324057012866 Walker B; other site 324057012867 D-loop; other site 324057012868 H-loop/switch region; other site 324057012869 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324057012870 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057012871 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324057012872 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057012873 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057012874 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057012875 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057012876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057012877 Helix-turn-helix domains; Region: HTH; cl00088 324057012878 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 324057012879 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 324057012880 CysD dimerization site [polypeptide binding]; other site 324057012881 G1 box; other site 324057012882 putative GEF interaction site [polypeptide binding]; other site 324057012883 GTP/Mg2+ binding site [chemical binding]; other site 324057012884 Switch I region; other site 324057012885 G2 box; other site 324057012886 G3 box; other site 324057012887 Switch II region; other site 324057012888 G4 box; other site 324057012889 G5 box; other site 324057012890 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 324057012891 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 324057012892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057012893 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 324057012894 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 324057012895 Active Sites [active] 324057012896 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057012897 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057012898 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057012899 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 324057012900 active site 324057012901 catalytic triad [active] 324057012902 oxyanion hole [active] 324057012903 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 324057012904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012905 dimer interface [polypeptide binding]; other site 324057012906 conserved gate region; other site 324057012907 ABC-ATPase subunit interface; other site 324057012908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057012909 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 324057012910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012911 dimer interface [polypeptide binding]; other site 324057012912 conserved gate region; other site 324057012913 ABC-ATPase subunit interface; other site 324057012914 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057012915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012916 dimer interface [polypeptide binding]; other site 324057012917 conserved gate region; other site 324057012918 putative PBP binding loops; other site 324057012919 ABC-ATPase subunit interface; other site 324057012920 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057012921 putative metal binding site [ion binding]; other site 324057012922 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057012923 putative metal binding site [ion binding]; other site 324057012924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057012927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012928 Response regulator receiver domain; Region: Response_reg; pfam00072 324057012929 active site 324057012930 phosphorylation site [posttranslational modification] 324057012931 intermolecular recognition site; other site 324057012932 dimerization interface [polypeptide binding]; other site 324057012933 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057012934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012935 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057012936 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 324057012937 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 324057012938 putative ligand binding site [chemical binding]; other site 324057012939 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 324057012940 Ca binding site [ion binding]; other site 324057012941 carbohydrate binding site [chemical binding]; other site 324057012942 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057012943 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057012944 Walker A/P-loop; other site 324057012945 ATP binding site [chemical binding]; other site 324057012946 Q-loop/lid; other site 324057012947 ABC transporter signature motif; other site 324057012948 Walker B; other site 324057012949 D-loop; other site 324057012950 H-loop/switch region; other site 324057012951 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 324057012952 FtsX-like permease family; Region: FtsX; cl15850 324057012953 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 324057012954 FtsX-like permease family; Region: FtsX; cl15850 324057012955 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057012956 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057012957 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057012958 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057012959 Walker A/P-loop; other site 324057012960 ATP binding site [chemical binding]; other site 324057012961 Q-loop/lid; other site 324057012962 ABC transporter signature motif; other site 324057012963 Walker B; other site 324057012964 D-loop; other site 324057012965 H-loop/switch region; other site 324057012966 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 324057012967 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057012968 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 324057012969 active site 324057012970 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 324057012971 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057012972 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057012973 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057012974 Walker A/P-loop; other site 324057012975 ATP binding site [chemical binding]; other site 324057012976 Q-loop/lid; other site 324057012977 ABC transporter signature motif; other site 324057012978 Walker B; other site 324057012979 D-loop; other site 324057012980 H-loop/switch region; other site 324057012981 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057012982 Cupin domain; Region: Cupin_2; cl09118 324057012983 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012985 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 324057012986 substrate binding site [chemical binding]; other site 324057012987 active site 324057012988 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057012989 metal binding site [ion binding]; metal-binding site 324057012990 ligand binding site [chemical binding]; other site 324057012991 Response regulator receiver domain; Region: Response_reg; pfam00072 324057012992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012993 active site 324057012994 phosphorylation site [posttranslational modification] 324057012995 intermolecular recognition site; other site 324057012996 dimerization interface [polypeptide binding]; other site 324057012997 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057012998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012999 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057013000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013001 dimerization interface [polypeptide binding]; other site 324057013002 Histidine kinase; Region: His_kinase; pfam06580 324057013003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057013004 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013005 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057013006 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 324057013007 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 324057013008 putative sugar binding sites [chemical binding]; other site 324057013009 Q-X-W motif; other site 324057013010 hypothetical protein; Provisional; Region: PRK05849 324057013011 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013013 Carboxylesterase family; Region: COesterase; pfam00135 324057013014 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057013015 substrate binding pocket [chemical binding]; other site 324057013016 catalytic triad [active] 324057013017 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057013018 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013020 active site 324057013021 phosphorylation site [posttranslational modification] 324057013022 intermolecular recognition site; other site 324057013023 dimerization interface [polypeptide binding]; other site 324057013024 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057013027 Histidine kinase; Region: His_kinase; pfam06580 324057013028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013029 ATP binding site [chemical binding]; other site 324057013030 Mg2+ binding site [ion binding]; other site 324057013031 G-X-G motif; other site 324057013032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057013033 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057013034 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013037 dimer interface [polypeptide binding]; other site 324057013038 conserved gate region; other site 324057013039 putative PBP binding loops; other site 324057013040 ABC-ATPase subunit interface; other site 324057013041 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057013043 Cupin domain; Region: Cupin_2; cl09118 324057013044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013046 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057013047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057013048 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057013049 dockerin binding interface; other site 324057013050 S-layer homology domain; Region: SLH; pfam00395 324057013051 S-layer homology domain; Region: SLH; pfam00395 324057013052 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 324057013053 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057013054 dockerin binding interface; other site 324057013055 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013057 dimer interface [polypeptide binding]; other site 324057013058 conserved gate region; other site 324057013059 ABC-ATPase subunit interface; other site 324057013060 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057013061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013062 dimer interface [polypeptide binding]; other site 324057013063 conserved gate region; other site 324057013064 putative PBP binding loops; other site 324057013065 ABC-ATPase subunit interface; other site 324057013066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057013067 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013069 active site 324057013070 phosphorylation site [posttranslational modification] 324057013071 intermolecular recognition site; other site 324057013072 dimerization interface [polypeptide binding]; other site 324057013073 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057013076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013077 dimerization interface [polypeptide binding]; other site 324057013078 Histidine kinase; Region: His_kinase; pfam06580 324057013079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013080 ATP binding site [chemical binding]; other site 324057013081 Mg2+ binding site [ion binding]; other site 324057013082 G-X-G motif; other site 324057013083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057013084 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 324057013085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013086 NAD(P) binding site [chemical binding]; other site 324057013087 active site 324057013088 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057013089 Cupin domain; Region: Cupin_2; cl09118 324057013090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013092 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057013093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013094 NAD(P) binding site [chemical binding]; other site 324057013095 active site 324057013096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057013097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057013098 DNA binding residues [nucleotide binding] 324057013099 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 324057013100 TIGR02679 family protein; Region: TIGR02679 324057013101 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 324057013102 TIGR02680 family protein; Region: TIGR02680 324057013103 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 324057013104 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 324057013105 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 324057013106 TIGR02677 family protein; Region: TIGR02677 324057013107 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057013108 DNA binding residues [nucleotide binding] 324057013109 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324057013110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013111 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 324057013112 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013113 Walker A/P-loop; other site 324057013114 ATP binding site [chemical binding]; other site 324057013115 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 324057013116 putative active site [active] 324057013117 putative metal-binding site [ion binding]; other site 324057013118 sporulation sigma factor SigK; Reviewed; Region: PRK05803 324057013119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057013120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057013121 DNA binding residues [nucleotide binding] 324057013122 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057013123 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 324057013124 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 324057013125 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 324057013126 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 324057013127 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057013128 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 324057013129 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 324057013130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057013131 FeS/SAM binding site; other site 324057013132 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 324057013133 active site 324057013134 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 324057013135 Ligand Binding Site [chemical binding]; other site 324057013136 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 324057013137 Moco binding site; other site 324057013138 metal coordination site [ion binding]; other site 324057013139 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 324057013140 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 324057013141 dockerin binding interface; other site 324057013142 S-layer homology domain; Region: SLH; pfam00395 324057013143 S-layer homology domain; Region: SLH; pfam00395 324057013144 S-layer homology domain; Region: SLH; pfam00395 324057013145 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057013146 Helix-turn-helix domains; Region: HTH; cl00088 324057013147 Helix-turn-helix domains; Region: HTH; cl00088 324057013148 UreD urease accessory protein; Region: UreD; cl00530 324057013149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013150 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 324057013151 UreF; Region: UreF; pfam01730 324057013152 urease subunit alpha; Reviewed; Region: ureC; PRK13207 324057013153 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 324057013154 subunit interactions [polypeptide binding]; other site 324057013155 active site 324057013156 flap region; other site 324057013157 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 324057013158 gamma-beta subunit interface [polypeptide binding]; other site 324057013159 alpha-beta subunit interface [polypeptide binding]; other site 324057013160 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 324057013161 alpha-gamma subunit interface [polypeptide binding]; other site 324057013162 beta-gamma subunit interface [polypeptide binding]; other site 324057013163 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057013164 TM-ABC transporter signature motif; other site 324057013165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013166 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 324057013167 Walker A/P-loop; other site 324057013168 ATP binding site [chemical binding]; other site 324057013169 Q-loop/lid; other site 324057013170 ABC transporter signature motif; other site 324057013171 Walker B; other site 324057013172 D-loop; other site 324057013173 H-loop/switch region; other site 324057013174 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057013175 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 324057013176 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 324057013177 ligand binding site [chemical binding]; other site 324057013178 calcium binding site [ion binding]; other site 324057013179 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057013180 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057013181 Cache domain; Region: Cache_1; pfam02743 324057013182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013183 dimerization interface [polypeptide binding]; other site 324057013184 Histidine kinase; Region: His_kinase; pfam06580 324057013185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013186 ATP binding site [chemical binding]; other site 324057013187 Mg2+ binding site [ion binding]; other site 324057013188 G-X-G motif; other site 324057013189 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057013190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013191 active site 324057013192 phosphorylation site [posttranslational modification] 324057013193 intermolecular recognition site; other site 324057013194 dimerization interface [polypeptide binding]; other site 324057013195 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013197 Dehydratase family; Region: ILVD_EDD; cl00340 324057013198 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 324057013199 NodB motif; other site 324057013200 putative active site [active] 324057013201 putative catalytic site [active] 324057013202 putative Zn binding site [ion binding]; other site 324057013203 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 324057013204 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 324057013205 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057013206 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057013207 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 324057013208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057013209 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057013210 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057013211 dimer interface [polypeptide binding]; other site 324057013212 putative CheW interface [polypeptide binding]; other site 324057013213 YceG-like family; Region: YceG; pfam02618 324057013214 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 324057013215 dimerization interface [polypeptide binding]; other site 324057013216 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 324057013217 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 324057013218 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 324057013219 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 324057013220 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 324057013221 motif 1; other site 324057013222 active site 324057013223 motif 2; other site 324057013224 motif 3; other site 324057013225 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 324057013226 DHHA1 domain; Region: DHHA1; pfam02272 324057013227 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057013228 Helix-turn-helix domains; Region: HTH; cl00088 324057013229 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057013230 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 324057013231 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057013232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057013233 catalytic residue [active] 324057013234 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 324057013235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057013236 active site 324057013237 motif I; other site 324057013238 motif II; other site 324057013239 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 324057013240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013241 dimer interface [polypeptide binding]; other site 324057013242 conserved gate region; other site 324057013243 putative PBP binding loops; other site 324057013244 ABC-ATPase subunit interface; other site 324057013245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013246 dimer interface [polypeptide binding]; other site 324057013247 conserved gate region; other site 324057013248 putative PBP binding loops; other site 324057013249 ABC-ATPase subunit interface; other site 324057013250 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 324057013251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013252 Walker A/P-loop; other site 324057013253 ATP binding site [chemical binding]; other site 324057013254 Q-loop/lid; other site 324057013255 ABC transporter signature motif; other site 324057013256 Walker B; other site 324057013257 D-loop; other site 324057013258 H-loop/switch region; other site 324057013259 TOBE domain; Region: TOBE_2; cl01440 324057013260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057013261 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 324057013262 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 324057013263 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 324057013264 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057013265 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 324057013266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057013267 catalytic residue [active] 324057013268 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057013269 Helix-turn-helix domains; Region: HTH; cl00088 324057013270 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 324057013271 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 324057013272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324057013273 Domain of unknown function DUF21; Region: DUF21; pfam01595 324057013274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324057013275 Transporter associated domain; Region: CorC_HlyC; cl08393 324057013276 Bacterial Ig-like domain; Region: Big_5; cl01012 324057013277 Copper resistance protein D; Region: CopD; cl00563 324057013278 Helix-turn-helix domains; Region: HTH; cl00088 324057013279 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057013280 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057013281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057013282 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 324057013283 putative NAD(P) binding site [chemical binding]; other site 324057013284 catalytic Zn binding site [ion binding]; other site 324057013285 structural Zn binding site [ion binding]; other site 324057013286 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057013287 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057013288 siderophore binding site; other site 324057013289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057013290 ABC-ATPase subunit interface; other site 324057013291 dimer interface [polypeptide binding]; other site 324057013292 putative PBP binding regions; other site 324057013293 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057013294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057013295 ABC-ATPase subunit interface; other site 324057013296 dimer interface [polypeptide binding]; other site 324057013297 putative PBP binding regions; other site 324057013298 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057013299 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057013300 Walker A/P-loop; other site 324057013301 ATP binding site [chemical binding]; other site 324057013302 Q-loop/lid; other site 324057013303 ABC transporter signature motif; other site 324057013304 Walker B; other site 324057013305 D-loop; other site 324057013306 H-loop/switch region; other site 324057013307 sensory histidine kinase DcuS; Provisional; Region: PRK11086 324057013308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013309 ATP binding site [chemical binding]; other site 324057013310 Mg2+ binding site [ion binding]; other site 324057013311 G-X-G motif; other site 324057013312 recombination factor protein RarA; Reviewed; Region: PRK13342 324057013313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057013314 Walker A motif; other site 324057013315 ATP binding site [chemical binding]; other site 324057013316 Walker B motif; other site 324057013317 arginine finger; other site 324057013318 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 324057013319 mannonate dehydratase; Region: uxuA; TIGR00695 324057013320 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057013321 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057013322 dimer interface [polypeptide binding]; other site 324057013323 putative CheW interface [polypeptide binding]; other site 324057013324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057013325 PAS domain; Region: PAS_9; pfam13426 324057013326 putative active site [active] 324057013327 heme pocket [chemical binding]; other site 324057013328 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 324057013329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057013330 putative active site [active] 324057013331 heme pocket [chemical binding]; other site 324057013332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057013333 putative active site [active] 324057013334 heme pocket [chemical binding]; other site 324057013335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057013336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057013337 metal binding site [ion binding]; metal-binding site 324057013338 active site 324057013339 I-site; other site 324057013340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057013341 PilZ domain; Region: PilZ; cl01260 324057013342 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 324057013343 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 324057013344 putative ATP binding site [chemical binding]; other site 324057013345 putative substrate interface [chemical binding]; other site 324057013346 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 324057013347 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 324057013348 dimer interface [polypeptide binding]; other site 324057013349 anticodon binding site; other site 324057013350 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 324057013351 homodimer interface [polypeptide binding]; other site 324057013352 motif 1; other site 324057013353 active site 324057013354 motif 2; other site 324057013355 GAD domain; Region: GAD; pfam02938 324057013356 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 324057013357 motif 3; other site 324057013358 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 324057013359 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 324057013360 dimer interface [polypeptide binding]; other site 324057013361 motif 1; other site 324057013362 active site 324057013363 motif 2; other site 324057013364 motif 3; other site 324057013365 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 324057013366 anticodon binding site; other site 324057013367 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 324057013368 putative active site [active] 324057013369 dimerization interface [polypeptide binding]; other site 324057013370 putative tRNAtyr binding site [nucleotide binding]; other site 324057013371 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324057013372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057013373 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324057013374 synthetase active site [active] 324057013375 NTP binding site [chemical binding]; other site 324057013376 metal binding site [ion binding]; metal-binding site 324057013377 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 324057013378 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 324057013379 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057013380 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057013381 Histidine kinase; Region: His_kinase; pfam06580 324057013382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013383 ATP binding site [chemical binding]; other site 324057013384 Mg2+ binding site [ion binding]; other site 324057013385 G-X-G motif; other site 324057013386 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013388 active site 324057013389 phosphorylation site [posttranslational modification] 324057013390 intermolecular recognition site; other site 324057013391 dimerization interface [polypeptide binding]; other site 324057013392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013393 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057013396 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013398 dimer interface [polypeptide binding]; other site 324057013399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057013400 ABC-ATPase subunit interface; other site 324057013401 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057013403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057013404 active site 324057013405 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 324057013406 DHH family; Region: DHH; pfam01368 324057013407 DHHA1 domain; Region: DHHA1; pfam02272 324057013408 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 324057013409 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057013410 Cation efflux family; Region: Cation_efflux; cl00316 324057013411 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 324057013412 Protein export membrane protein; Region: SecD_SecF; cl14618 324057013413 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 324057013414 Protein export membrane protein; Region: SecD_SecF; cl14618 324057013415 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 324057013416 stage V sporulation protein B; Region: spore_V_B; TIGR02900 324057013417 MatE; Region: MatE; cl10513 324057013418 Protein of unknown function (DUF421); Region: DUF421; cl00990 324057013419 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 324057013420 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 324057013421 transmembrane helices; other site 324057013422 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 324057013423 Preprotein translocase subunit; Region: YajC; cl00806 324057013424 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 324057013425 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 324057013426 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 324057013427 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 324057013428 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 324057013429 Stage II sporulation protein; Region: SpoIID; pfam08486 324057013430 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 324057013431 Protein of unknown function, DUF393; Region: DUF393; cl01136 324057013432 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 324057013433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057013434 Walker A motif; other site 324057013435 ATP binding site [chemical binding]; other site 324057013436 Walker B motif; other site 324057013437 arginine finger; other site 324057013438 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 324057013439 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 324057013440 RuvA N terminal domain; Region: RuvA_N; pfam01330 324057013441 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 324057013442 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 324057013443 active site 324057013444 putative DNA-binding cleft [nucleotide binding]; other site 324057013445 dimer interface [polypeptide binding]; other site 324057013446 BofC C-terminal domain; Region: BofC_C; pfam08955 324057013447 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057013448 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 324057013449 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057013450 prephenate dehydratase; Provisional; Region: PRK11898 324057013451 Prephenate dehydratase; Region: PDT; pfam00800 324057013452 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 324057013453 putative L-Phe binding site [chemical binding]; other site 324057013454 homoserine kinase; Provisional; Region: PRK01212 324057013455 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057013456 homoserine dehydrogenase; Provisional; Region: PRK06349 324057013457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013458 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 324057013459 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 324057013460 hypothetical protein; Provisional; Region: PRK04435 324057013461 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057013462 GTPase CgtA; Reviewed; Region: obgE; PRK12297 324057013463 GTP1/OBG; Region: GTP1_OBG; pfam01018 324057013464 Obg GTPase; Region: Obg; cd01898 324057013465 G1 box; other site 324057013466 GTP/Mg2+ binding site [chemical binding]; other site 324057013467 Switch I region; other site 324057013468 G2 box; other site 324057013469 G3 box; other site 324057013470 Switch II region; other site 324057013471 G4 box; other site 324057013472 G5 box; other site 324057013473 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 324057013474 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 324057013475 Protein of unknown function (DUF464); Region: DUF464; cl01080 324057013476 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 324057013477 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 324057013478 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 324057013479 homodimer interface [polypeptide binding]; other site 324057013480 oligonucleotide binding site [chemical binding]; other site 324057013481 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 324057013482 active site 324057013483 putative substrate binding region [chemical binding]; other site 324057013484 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057013485 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 324057013486 septum site-determining protein MinD; Region: minD_bact; TIGR01968 324057013487 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 324057013488 Switch I; other site 324057013489 Switch II; other site 324057013490 septum formation inhibitor; Reviewed; Region: minC; PRK00513 324057013491 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 324057013492 rod shape-determining protein MreD; Region: MreD; cl01087 324057013493 rod shape-determining protein MreC; Provisional; Region: PRK13922 324057013494 rod shape-determining protein MreC; Region: MreC; pfam04085 324057013495 rod shape-determining protein MreB; Provisional; Region: PRK13927 324057013496 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 324057013497 ATP binding site [chemical binding]; other site 324057013498 profilin binding site; other site 324057013499 hypothetical protein; Reviewed; Region: PRK00024 324057013500 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 324057013501 MPN+ (JAMM) motif; other site 324057013502 Zinc-binding site [ion binding]; other site 324057013503 Maf-like protein; Region: Maf; pfam02545 324057013504 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 324057013505 active site 324057013506 dimer interface [polypeptide binding]; other site 324057013507 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 324057013508 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 324057013509 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324057013510 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057013511 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057013512 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 324057013513 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057013514 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057013515 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 324057013516 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057013517 active site 324057013518 HIGH motif; other site 324057013519 nucleotide binding site [chemical binding]; other site 324057013520 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324057013521 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 324057013522 active site 324057013523 KMSKS motif; other site 324057013524 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 324057013525 tRNA binding surface [nucleotide binding]; other site 324057013526 anticodon binding site; other site 324057013527 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 324057013528 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057013529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013530 putative substrate translocation pore; other site 324057013531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057013533 Helix-turn-helix domains; Region: HTH; cl00088 324057013534 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 324057013535 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 324057013536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 324057013537 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057013538 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057013539 active site 324057013540 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 324057013541 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057013542 inhibitor-cofactor binding pocket; inhibition site 324057013543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057013544 catalytic residue [active] 324057013545 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 324057013546 dimer interface [polypeptide binding]; other site 324057013547 active site 324057013548 Schiff base residues; other site 324057013549 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 324057013550 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 324057013551 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 324057013552 active site 324057013553 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 324057013554 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 324057013555 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 324057013556 domain interfaces; other site 324057013557 active site 324057013558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013559 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324057013560 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 324057013561 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 324057013562 tRNA; other site 324057013563 putative tRNA binding site [nucleotide binding]; other site 324057013564 putative NADP binding site [chemical binding]; other site 324057013565 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 324057013566 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 324057013567 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 324057013568 Predicted GTPase [General function prediction only]; Region: COG0218 324057013569 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 324057013570 G1 box; other site 324057013571 GTP/Mg2+ binding site [chemical binding]; other site 324057013572 Switch I region; other site 324057013573 G2 box; other site 324057013574 G3 box; other site 324057013575 Switch II region; other site 324057013576 G4 box; other site 324057013577 G5 box; other site 324057013578 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 324057013579 Found in ATP-dependent protease La (LON); Region: LON; smart00464 324057013580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057013581 Walker A motif; other site 324057013582 ATP binding site [chemical binding]; other site 324057013583 Walker B motif; other site 324057013584 arginine finger; other site 324057013585 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 324057013586 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 324057013587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057013588 Walker A motif; other site 324057013589 ATP binding site [chemical binding]; other site 324057013590 Walker B motif; other site 324057013591 arginine finger; other site 324057013592 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 324057013593 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 324057013594 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 324057013595 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 324057013596 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 324057013597 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 324057013598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057013599 Walker A motif; other site 324057013600 ATP binding site [chemical binding]; other site 324057013601 Walker B motif; other site 324057013602 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 324057013603 Clp protease; Region: CLP_protease; pfam00574 324057013604 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324057013605 oligomer interface [polypeptide binding]; other site 324057013606 active site residues [active] 324057013607 trigger factor; Provisional; Region: tig; PRK01490 324057013608 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 324057013609 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 324057013610 Helix-turn-helix domains; Region: HTH; cl00088 324057013611 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 324057013612 dimer interface [polypeptide binding]; other site 324057013613 FMN binding site [chemical binding]; other site 324057013614 AAA domain; Region: AAA_33; pfam13671 324057013615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013616 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 324057013617 active site 324057013618 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 324057013619 dimer interface [polypeptide binding]; other site 324057013620 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 324057013621 Ligand Binding Site [chemical binding]; other site 324057013622 Molecular Tunnel; other site 324057013623 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 324057013624 active site 324057013625 dimerization interface [polypeptide binding]; other site 324057013626 ribonuclease PH; Reviewed; Region: rph; PRK00173 324057013627 Ribonuclease PH; Region: RNase_PH_bact; cd11362 324057013628 hexamer interface [polypeptide binding]; other site 324057013629 active site 324057013630 Sporulation and spore germination; Region: Germane; cl11253 324057013631 Sporulation and spore germination; Region: Germane; cl11253 324057013632 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 324057013633 tetramer interfaces [polypeptide binding]; other site 324057013634 binuclear metal-binding site [ion binding]; other site 324057013635 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 324057013636 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 324057013637 ligand-binding site [chemical binding]; other site 324057013638 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 324057013639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057013640 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 324057013641 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 324057013642 homotetramer interface [polypeptide binding]; other site 324057013643 FMN binding site [chemical binding]; other site 324057013644 homodimer contacts [polypeptide binding]; other site 324057013645 putative active site [active] 324057013646 putative substrate binding site [chemical binding]; other site 324057013647 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 324057013648 active site 324057013649 trimer interface [polypeptide binding]; other site 324057013650 allosteric site; other site 324057013651 active site lid [active] 324057013652 hexamer (dimer of trimers) interface [polypeptide binding]; other site 324057013653 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 324057013654 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 324057013655 active site 324057013656 dimer interface [polypeptide binding]; other site 324057013657 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057013658 Helix-turn-helix domains; Region: HTH; cl00088 324057013659 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057013660 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057013661 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 324057013662 substrate binding site [chemical binding]; other site 324057013663 ATP binding site [chemical binding]; other site 324057013664 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 324057013665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057013666 ATP binding site [chemical binding]; other site 324057013667 putative Mg++ binding site [ion binding]; other site 324057013668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057013669 nucleotide binding region [chemical binding]; other site 324057013670 ATP-binding site [chemical binding]; other site 324057013671 RQC domain; Region: RQC; cl09632 324057013672 HRDC domain; Region: HRDC; cl02578 324057013673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 324057013674 malate dehydrogenase; Reviewed; Region: PRK06223 324057013675 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 324057013676 NAD(P) binding site [chemical binding]; other site 324057013677 dimer interface [polypeptide binding]; other site 324057013678 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057013679 substrate binding site [chemical binding]; other site 324057013680 isocitrate dehydrogenase; Validated; Region: PRK07362 324057013681 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 324057013682 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 324057013683 dimer interface [polypeptide binding]; other site 324057013684 Citrate synthase; Region: Citrate_synt; pfam00285 324057013685 active site 324057013686 citrylCoA binding site [chemical binding]; other site 324057013687 oxalacetate/citrate binding site [chemical binding]; other site 324057013688 coenzyme A binding site [chemical binding]; other site 324057013689 catalytic triad [active] 324057013690 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 324057013691 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 324057013692 polyphosphate kinase; Provisional; Region: PRK05443 324057013693 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 324057013694 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 324057013695 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 324057013696 putative domain interface [polypeptide binding]; other site 324057013697 putative active site [active] 324057013698 catalytic site [active] 324057013699 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 324057013700 putative domain interface [polypeptide binding]; other site 324057013701 putative active site [active] 324057013702 catalytic site [active] 324057013703 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 324057013704 active site 324057013705 pyruvate kinase; Provisional; Region: PRK06354 324057013706 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 324057013707 domain interfaces; other site 324057013708 active site 324057013709 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 324057013710 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 324057013711 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 324057013712 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 324057013713 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 324057013714 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 324057013715 tetramer interfaces [polypeptide binding]; other site 324057013716 binuclear metal-binding site [ion binding]; other site 324057013717 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 324057013718 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 324057013719 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 324057013720 generic binding surface I; other site 324057013721 generic binding surface II; other site 324057013722 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 324057013723 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 324057013724 YtpI-like protein; Region: YtpI; pfam14007 324057013725 GTPase RsgA; Reviewed; Region: PRK01889 324057013726 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057013727 RNA binding site [nucleotide binding]; other site 324057013728 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 324057013729 GTPase/Zn-binding domain interface [polypeptide binding]; other site 324057013730 GTP/Mg2+ binding site [chemical binding]; other site 324057013731 G4 box; other site 324057013732 G5 box; other site 324057013733 G1 box; other site 324057013734 Switch I region; other site 324057013735 G2 box; other site 324057013736 G3 box; other site 324057013737 Switch II region; other site 324057013738 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 324057013739 Helix-turn-helix domains; Region: HTH; cl00088 324057013740 DNA-binding site [nucleotide binding]; DNA binding site 324057013741 DRTGG domain; Region: DRTGG; cl12147 324057013742 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 324057013743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057013744 non-specific DNA binding site [nucleotide binding]; other site 324057013745 salt bridge; other site 324057013746 sequence-specific DNA binding site [nucleotide binding]; other site 324057013747 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057013748 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057013749 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057013750 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057013751 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057013752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057013753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013754 active site 324057013755 phosphorylation site [posttranslational modification] 324057013756 intermolecular recognition site; other site 324057013757 dimerization interface [polypeptide binding]; other site 324057013758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057013759 DNA binding site [nucleotide binding] 324057013760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057013761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013762 dimerization interface [polypeptide binding]; other site 324057013763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057013764 dimer interface [polypeptide binding]; other site 324057013765 phosphorylation site [posttranslational modification] 324057013766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013767 ATP binding site [chemical binding]; other site 324057013768 Mg2+ binding site [ion binding]; other site 324057013769 G-X-G motif; other site 324057013770 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057013771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057013772 motif II; other site 324057013773 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057013774 NMT1-like family; Region: NMT1_2; cl15260 324057013775 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 324057013776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013777 dimer interface [polypeptide binding]; other site 324057013778 conserved gate region; other site 324057013779 ABC-ATPase subunit interface; other site 324057013780 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 324057013781 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 324057013782 Walker A/P-loop; other site 324057013783 ATP binding site [chemical binding]; other site 324057013784 Q-loop/lid; other site 324057013785 ABC transporter signature motif; other site 324057013786 Walker B; other site 324057013787 D-loop; other site 324057013788 H-loop/switch region; other site 324057013789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 324057013790 Predicted transcriptional regulators [Transcription]; Region: COG1510 324057013791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013793 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057013794 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057013795 intersubunit interface [polypeptide binding]; other site 324057013796 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057013797 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057013798 intersubunit interface [polypeptide binding]; other site 324057013799 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 324057013800 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 324057013801 active site 324057013802 substrate binding site [chemical binding]; other site 324057013803 trimer interface [polypeptide binding]; other site 324057013804 CoA binding site [chemical binding]; other site 324057013805 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057013806 MatE; Region: MatE; cl10513 324057013807 Cupin domain; Region: Cupin_2; cl09118 324057013808 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013810 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 324057013811 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 324057013812 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057013813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057013814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057013815 DNA binding residues [nucleotide binding] 324057013816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057013817 Helix-turn-helix domains; Region: HTH; cl00088 324057013818 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057013819 putative dimerization interface [polypeptide binding]; other site 324057013820 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057013821 Spore germination protein; Region: Spore_permease; cl15802 324057013822 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057013823 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057013824 Cation efflux family; Region: Cation_efflux; cl00316 324057013825 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057013826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013827 NAD(P) binding site [chemical binding]; other site 324057013828 active site 324057013829 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057013830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057013831 active site 324057013832 catalytic tetrad [active] 324057013833 Helix-turn-helix domains; Region: HTH; cl00088 324057013834 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 324057013835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057013836 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 324057013837 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013838 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013839 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013840 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013841 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013842 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013843 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013844 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057013845 Phosphoesterase family; Region: Phosphoesterase; cl15450 324057013846 YusW-like protein; Region: YusW; pfam14039 324057013847 Haemolysin-III related; Region: HlyIII; cl03831 324057013848 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057013849 DinB superfamily; Region: DinB_2; pfam12867 324057013850 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 324057013851 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 324057013852 Helix-turn-helix domains; Region: HTH; cl00088 324057013853 Helix-turn-helix domains; Region: HTH; cl00088 324057013854 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057013855 putative dimerization interface [polypeptide binding]; other site 324057013856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057013858 putative substrate translocation pore; other site 324057013859 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057013860 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 324057013861 DNA binding residues [nucleotide binding] 324057013862 dimer interface [polypeptide binding]; other site 324057013863 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324057013864 dimer interface [polypeptide binding]; other site 324057013865 FMN binding site [chemical binding]; other site 324057013866 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 324057013867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013868 dimerization interface [polypeptide binding]; other site 324057013869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057013870 dimer interface [polypeptide binding]; other site 324057013871 phosphorylation site [posttranslational modification] 324057013872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013873 ATP binding site [chemical binding]; other site 324057013874 Mg2+ binding site [ion binding]; other site 324057013875 G-X-G motif; other site 324057013876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057013877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013878 active site 324057013879 phosphorylation site [posttranslational modification] 324057013880 intermolecular recognition site; other site 324057013881 dimerization interface [polypeptide binding]; other site 324057013882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057013883 DNA binding site [nucleotide binding] 324057013884 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057013885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057013886 S-adenosylmethionine binding site [chemical binding]; other site 324057013887 Helix-turn-helix domains; Region: HTH; cl00088 324057013888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057013889 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 324057013890 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057013891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057013892 active site 324057013893 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 324057013894 putative dimer interface [polypeptide binding]; other site 324057013895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057013896 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 324057013897 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057013898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057013900 putative substrate translocation pore; other site 324057013901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013902 putative substrate translocation pore; other site 324057013903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057013904 putative DNA binding site [nucleotide binding]; other site 324057013905 dimerization interface [polypeptide binding]; other site 324057013906 putative Zn2+ binding site [ion binding]; other site 324057013907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057013908 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057013909 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057013910 MatE; Region: MatE; cl10513 324057013911 MatE; Region: MatE; cl10513 324057013912 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 324057013913 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 324057013914 active site 324057013915 substrate binding site [chemical binding]; other site 324057013916 trimer interface [polypeptide binding]; other site 324057013917 CoA binding site [chemical binding]; other site 324057013918 Cupin domain; Region: Cupin_2; cl09118 324057013919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013922 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324057013923 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 324057013924 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057013925 catalytic core [active] 324057013926 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 324057013927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057013928 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 324057013929 putative hydrophobic ligand binding site [chemical binding]; other site 324057013930 RNA polymerase factor sigma-70; Validated; Region: PRK08241 324057013931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057013932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057013933 DNA binding residues [nucleotide binding] 324057013934 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 324057013935 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 324057013936 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 324057013937 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 324057013938 DNA-binding site [nucleotide binding]; DNA binding site 324057013939 RNA-binding motif; other site 324057013940 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 324057013941 dimer interface [polypeptide binding]; other site 324057013942 FMN binding site [chemical binding]; other site 324057013943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057013945 putative substrate translocation pore; other site 324057013946 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324057013947 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324057013948 catalytic residues [active] 324057013949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057013950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057013952 Helix-turn-helix domains; Region: HTH; cl00088 324057013953 Transposase; Region: DEDD_Tnp_IS110; pfam01548 324057013954 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 324057013955 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 324057013956 RNAase interaction site [polypeptide binding]; other site 324057013957 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057013958 putative hydrophobic ligand binding site [chemical binding]; other site 324057013959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057013960 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 324057013961 VanZ like family; Region: VanZ; cl01971 324057013962 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057013963 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057013964 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057013965 S-layer homology domain; Region: SLH; pfam00395 324057013966 S-layer homology domain; Region: SLH; pfam00395 324057013967 S-layer homology domain; Region: SLH; pfam00395 324057013968 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 324057013969 dimanganese center [ion binding]; other site 324057013970 CotJB protein; Region: CotJB; pfam12652 324057013971 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 324057013972 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 324057013973 Domain of unknown function DUF20; Region: UPF0118; pfam01594 324057013974 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 324057013975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057013976 FeS/SAM binding site; other site 324057013977 YfkB-like domain; Region: YfkB; pfam08756 324057013978 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057013979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057013980 Zn2+ binding site [ion binding]; other site 324057013981 Mg2+ binding site [ion binding]; other site 324057013982 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 324057013983 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 324057013984 active site 324057013985 metal binding site [ion binding]; metal-binding site 324057013986 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057013987 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 324057013988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057013989 FeS/SAM binding site; other site 324057013990 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 324057013991 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 324057013992 MoaE interaction surface [polypeptide binding]; other site 324057013993 MoeB interaction surface [polypeptide binding]; other site 324057013994 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 324057013995 MoaE homodimer interface [polypeptide binding]; other site 324057013996 MoaD interaction [polypeptide binding]; other site 324057013997 active site residues [active] 324057013998 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057013999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057014000 Zn2+ binding site [ion binding]; other site 324057014001 Mg2+ binding site [ion binding]; other site 324057014002 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 324057014003 FeS assembly protein SufB; Region: sufB; TIGR01980 324057014004 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 324057014005 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 324057014006 trimerization site [polypeptide binding]; other site 324057014007 active site 324057014008 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 324057014009 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 324057014010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057014011 catalytic residue [active] 324057014012 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 324057014013 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 324057014014 FeS assembly ATPase SufC; Region: sufC; TIGR01978 324057014015 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 324057014016 Walker A/P-loop; other site 324057014017 ATP binding site [chemical binding]; other site 324057014018 Q-loop/lid; other site 324057014019 ABC transporter signature motif; other site 324057014020 Walker B; other site 324057014021 D-loop; other site 324057014022 H-loop/switch region; other site 324057014023 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 324057014024 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057014025 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 324057014026 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 324057014027 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 324057014028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057014029 PAS fold; Region: PAS_4; pfam08448 324057014030 putative active site [active] 324057014031 heme pocket [chemical binding]; other site 324057014032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057014033 metal binding site [ion binding]; metal-binding site 324057014034 active site 324057014035 I-site; other site 324057014036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057014037 Protein of unknown function (DUF423); Region: DUF423; cl01008 324057014038 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 324057014039 AAA domain; Region: AAA_23; pfam13476 324057014040 Walker A/P-loop; other site 324057014041 ATP binding site [chemical binding]; other site 324057014042 Q-loop/lid; other site 324057014043 exonuclease subunit SbcC; Provisional; Region: PRK10246 324057014044 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 324057014045 ABC transporter signature motif; other site 324057014046 Walker B; other site 324057014047 D-loop; other site 324057014048 H-loop/switch region; other site 324057014049 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 324057014050 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 324057014051 active site 324057014052 metal binding site [ion binding]; metal-binding site 324057014053 DNA binding site [nucleotide binding] 324057014054 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 324057014055 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 324057014056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014057 putative substrate translocation pore; other site 324057014058 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324057014059 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057014060 NAD binding site [chemical binding]; other site 324057014061 substrate binding site [chemical binding]; other site 324057014062 putative active site [active] 324057014063 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057014064 Helix-turn-helix domains; Region: HTH; cl00088 324057014065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057014066 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057014067 Helix-turn-helix domains; Region: HTH; cl00088 324057014068 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057014069 short chain dehydrogenase; Provisional; Region: PRK12939 324057014070 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 324057014071 NADP binding site [chemical binding]; other site 324057014072 homodimer interface [polypeptide binding]; other site 324057014073 active site 324057014074 substrate binding site [chemical binding]; other site 324057014075 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057014076 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057014077 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057014078 putative hydrophobic ligand binding site [chemical binding]; other site 324057014079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057014080 Helix-turn-helix domains; Region: HTH; cl00088 324057014081 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057014082 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057014083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057014084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014085 dimer interface [polypeptide binding]; other site 324057014086 conserved gate region; other site 324057014087 putative PBP binding loops; other site 324057014088 ABC-ATPase subunit interface; other site 324057014089 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057014090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014091 dimer interface [polypeptide binding]; other site 324057014092 conserved gate region; other site 324057014093 ABC-ATPase subunit interface; other site 324057014094 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057014095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014096 active site 324057014097 phosphorylation site [posttranslational modification] 324057014098 intermolecular recognition site; other site 324057014099 dimerization interface [polypeptide binding]; other site 324057014100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057014102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057014103 Histidine kinase; Region: His_kinase; pfam06580 324057014104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014105 ATP binding site [chemical binding]; other site 324057014106 Mg2+ binding site [ion binding]; other site 324057014107 G-X-G motif; other site 324057014108 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057014109 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057014110 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 324057014111 active site 324057014112 catalytic site [active] 324057014113 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057014114 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057014115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057014116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014117 dimer interface [polypeptide binding]; other site 324057014118 conserved gate region; other site 324057014119 putative PBP binding loops; other site 324057014120 ABC-ATPase subunit interface; other site 324057014121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014122 dimer interface [polypeptide binding]; other site 324057014123 conserved gate region; other site 324057014124 putative PBP binding loops; other site 324057014125 ABC-ATPase subunit interface; other site 324057014126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057014127 DNA-binding site [nucleotide binding]; DNA binding site 324057014128 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 324057014129 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057014130 ligand binding site [chemical binding]; other site 324057014131 dimerization interface [polypeptide binding]; other site 324057014132 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 324057014133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057014134 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 324057014135 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 324057014136 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057014137 active site 324057014138 nucleotide binding site [chemical binding]; other site 324057014139 HIGH motif; other site 324057014140 KMSKS motif; other site 324057014141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057014142 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 324057014143 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057014144 nudix motif; other site 324057014145 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 324057014146 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057014147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057014148 Family description; Region: UvrD_C_2; cl15862 324057014149 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057014150 putative active site [active] 324057014151 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 324057014152 Protein of unknown function DUF45; Region: DUF45; cl00636 324057014153 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 324057014154 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 324057014155 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 324057014156 S-layer homology domain; Region: SLH; pfam00395 324057014157 S-layer homology domain; Region: SLH; pfam00395 324057014158 S-layer homology domain; Region: SLH; pfam00395 324057014159 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 324057014160 additional DNA contacts [nucleotide binding]; other site 324057014161 mismatch recognition site; other site 324057014162 active site 324057014163 zinc binding site [ion binding]; other site 324057014164 DNA intercalation site [nucleotide binding]; other site 324057014165 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 324057014166 hypothetical protein; Reviewed; Region: PRK09588 324057014167 alpha-galactosidase; Provisional; Region: PRK15076 324057014168 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 324057014169 NAD binding site [chemical binding]; other site 324057014170 sugar binding site [chemical binding]; other site 324057014171 divalent metal binding site [ion binding]; other site 324057014172 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057014173 dimer interface [polypeptide binding]; other site 324057014174 Cupin domain; Region: Cupin_2; cl09118 324057014175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014177 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 324057014178 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 324057014179 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 324057014180 AMP-binding enzyme; Region: AMP-binding; cl15778 324057014181 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057014182 Fic/DOC family; Region: Fic; cl00960 324057014183 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 324057014184 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057014185 sugar binding site [chemical binding]; other site 324057014186 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 324057014187 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 324057014188 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014189 metal binding site [ion binding]; metal-binding site 324057014190 ligand binding site [chemical binding]; other site 324057014191 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014192 ligand binding site [chemical binding]; other site 324057014193 metal binding site [ion binding]; metal-binding site 324057014194 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014195 metal binding site [ion binding]; metal-binding site 324057014196 ligand binding site [chemical binding]; other site 324057014197 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014198 ligand binding site [chemical binding]; other site 324057014199 S-layer homology domain; Region: SLH; pfam00395 324057014200 S-layer homology domain; Region: SLH; pfam00395 324057014201 S-layer homology domain; Region: SLH; pfam00395 324057014202 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057014203 sugar binding site [chemical binding]; other site 324057014204 PA14 domain; Region: PA14; cl08459 324057014205 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 324057014206 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057014207 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057014208 active site 324057014209 metal binding site [ion binding]; metal-binding site 324057014210 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057014211 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 324057014212 FAD binding site [chemical binding]; other site 324057014213 Protein of unknown function (DUF402); Region: DUF402; cl00979 324057014214 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 324057014215 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057014216 putative active site [active] 324057014217 putative metal binding site [ion binding]; other site 324057014218 S-layer homology domain; Region: SLH; pfam00395 324057014219 S-layer homology domain; Region: SLH; pfam00395 324057014220 HupE / UreJ protein; Region: HupE_UreJ; cl01011 324057014221 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 324057014222 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 324057014223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014224 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057014225 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 324057014226 Helix-turn-helix domains; Region: HTH; cl00088 324057014227 phenylhydantoinase; Validated; Region: PRK08323 324057014228 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 324057014229 tetramer interface [polypeptide binding]; other site 324057014230 active site 324057014231 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 324057014232 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 324057014233 homodimer interface [polypeptide binding]; other site 324057014234 active site 324057014235 FMN binding site [chemical binding]; other site 324057014236 substrate binding site [chemical binding]; other site 324057014237 4Fe-4S binding domain; Region: Fer4; cl02805 324057014238 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 324057014239 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057014240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057014242 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 324057014243 N-carbamolyputrescine amidase; Region: PLN02747 324057014244 active site 324057014245 catalytic triad [active] 324057014246 dimer interface [polypeptide binding]; other site 324057014247 allantoate amidohydrolase; Reviewed; Region: PRK09290 324057014248 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 324057014249 active site 324057014250 metal binding site [ion binding]; metal-binding site 324057014251 dimer interface [polypeptide binding]; other site 324057014252 NMT1-like family; Region: NMT1_2; cl15260 324057014253 NMT1/THI5 like; Region: NMT1; pfam09084 324057014254 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057014255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057014256 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057014257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014258 dimer interface [polypeptide binding]; other site 324057014259 conserved gate region; other site 324057014260 putative PBP binding loops; other site 324057014261 ABC-ATPase subunit interface; other site 324057014262 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057014263 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057014264 Walker A/P-loop; other site 324057014265 ATP binding site [chemical binding]; other site 324057014266 Q-loop/lid; other site 324057014267 ABC transporter signature motif; other site 324057014268 Walker B; other site 324057014269 D-loop; other site 324057014270 H-loop/switch region; other site 324057014271 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 324057014272 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057014273 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057014274 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057014275 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 324057014276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057014277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014278 dimer interface [polypeptide binding]; other site 324057014279 conserved gate region; other site 324057014280 putative PBP binding loops; other site 324057014281 ABC-ATPase subunit interface; other site 324057014282 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057014283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014284 dimer interface [polypeptide binding]; other site 324057014285 conserved gate region; other site 324057014286 putative PBP binding loops; other site 324057014287 ABC-ATPase subunit interface; other site 324057014288 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057014289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057014290 dimerization interface [polypeptide binding]; other site 324057014291 Histidine kinase; Region: His_kinase; pfam06580 324057014292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057014293 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057014294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014295 active site 324057014296 phosphorylation site [posttranslational modification] 324057014297 intermolecular recognition site; other site 324057014298 dimerization interface [polypeptide binding]; other site 324057014299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014300 Uncharacterized conserved protein [Function unknown]; Region: COG2718 324057014301 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057014302 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 324057014303 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057014304 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 324057014305 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324057014306 FAD binding domain; Region: FAD_binding_4; pfam01565 324057014307 Berberine and berberine like; Region: BBE; pfam08031 324057014308 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057014309 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057014310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057014311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014312 putative substrate translocation pore; other site 324057014313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014314 F0F1-type ATP synthase, beta subunit [Energy production and conversion]; Region: AtpD; COG0055 324057014315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057014316 Walker A motif; other site 324057014317 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324057014318 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 324057014319 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 324057014320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014321 catalytic residue [active] 324057014322 hypothetical protein; Provisional; Region: PRK08201 324057014323 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 324057014324 metal binding site [ion binding]; metal-binding site 324057014325 putative dimer interface [polypeptide binding]; other site 324057014326 NMT1-like family; Region: NMT1_2; cl15260 324057014327 Glutaminase; Region: Glutaminase; cl00907 324057014328 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324057014329 active site 324057014330 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 324057014331 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 324057014332 generic binding surface I; other site 324057014333 generic binding surface II; other site 324057014334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057014335 S-layer homology domain; Region: SLH; pfam00395 324057014336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014337 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 324057014338 putative substrate translocation pore; other site 324057014339 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057014340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014341 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057014342 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057014343 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 324057014344 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 324057014345 TPP-binding site [chemical binding]; other site 324057014346 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 324057014347 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 324057014348 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324057014349 E3 interaction surface; other site 324057014350 lipoyl attachment site [posttranslational modification]; other site 324057014351 e3 binding domain; Region: E3_binding; pfam02817 324057014352 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 324057014353 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057014354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057014355 putative DNA binding site [nucleotide binding]; other site 324057014356 dimerization interface [polypeptide binding]; other site 324057014357 putative Zn2+ binding site [ion binding]; other site 324057014358 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057014359 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057014360 GAF domain; Region: GAF; cl15785 324057014361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057014362 metal binding site [ion binding]; metal-binding site 324057014363 active site 324057014364 I-site; other site 324057014365 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324057014366 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 324057014367 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 324057014368 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057014369 S-layer homology domain; Region: SLH; pfam00395 324057014370 S-layer homology domain; Region: SLH; pfam00395 324057014371 S-layer homology domain; Region: SLH; pfam00395 324057014372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057014373 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057014374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057014375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057014376 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057014377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014378 dimer interface [polypeptide binding]; other site 324057014379 conserved gate region; other site 324057014380 ABC-ATPase subunit interface; other site 324057014381 Response regulator receiver domain; Region: Response_reg; pfam00072 324057014382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014383 active site 324057014384 phosphorylation site [posttranslational modification] 324057014385 intermolecular recognition site; other site 324057014386 dimerization interface [polypeptide binding]; other site 324057014387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057014390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057014391 Histidine kinase; Region: His_kinase; pfam06580 324057014392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014393 ATP binding site [chemical binding]; other site 324057014394 Mg2+ binding site [ion binding]; other site 324057014395 G-X-G motif; other site 324057014396 Restriction endonuclease; Region: Mrr_cat; cl00516 324057014397 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 324057014398 SpoVR like protein; Region: SpoVR; pfam04293 324057014399 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 324057014400 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324057014401 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324057014402 HsdM N-terminal domain; Region: HsdM_N; pfam12161 324057014403 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 324057014404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057014405 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 324057014406 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 324057014407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057014408 ATP binding site [chemical binding]; other site 324057014409 putative Mg++ binding site [ion binding]; other site 324057014410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057014411 nucleotide binding region [chemical binding]; other site 324057014412 ATP-binding site [chemical binding]; other site 324057014413 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057014414 putative active site [active] 324057014415 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324057014416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057014417 ATP binding site [chemical binding]; other site 324057014418 putative Mg++ binding site [ion binding]; other site 324057014419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057014420 nucleotide binding region [chemical binding]; other site 324057014421 ATP-binding site [chemical binding]; other site 324057014422 NAD-dependent deacetylase; Provisional; Region: PRK00481 324057014423 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 324057014424 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057014425 WYL domain; Region: WYL; cl14852 324057014426 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324057014427 E2 (early) protein, N terminal; Region: PPV_E2_N; pfam00508 324057014428 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324057014429 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 324057014430 catalytic residues [active] 324057014431 catalytic nucleophile [active] 324057014432 Presynaptic Site I dimer interface [polypeptide binding]; other site 324057014433 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 324057014434 Synaptic Flat tetramer interface [polypeptide binding]; other site 324057014435 Recombinase; Region: Recombinase; pfam07508 324057014436 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324057014437 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 324057014438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057014439 non-specific DNA binding site [nucleotide binding]; other site 324057014440 salt bridge; other site 324057014441 sequence-specific DNA binding site [nucleotide binding]; other site 324057014442 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057014443 catalytic residues [active] 324057014444 catalytic nucleophile [active] 324057014445 Recombinase; Region: Recombinase; pfam07508 324057014446 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324057014447 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057014448 catalytic residues [active] 324057014449 catalytic nucleophile [active] 324057014450 Recombinase; Region: Recombinase; pfam07508 324057014451 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057014452 catalytic residues [active] 324057014453 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324057014454 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 324057014455 AAA domain; Region: AAA_21; pfam13304 324057014456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057014457 ABC transporter signature motif; other site 324057014458 Walker B; other site 324057014459 D-loop; other site 324057014460 H-loop/switch region; other site 324057014461 Restriction endonuclease; Region: Mrr_cat; cl00516 324057014462 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057014463 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057014464 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 324057014465 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057014466 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 324057014467 Uncharacterized conserved protein [Function unknown]; Region: COG2308 324057014468 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 324057014469 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 324057014470 heme-binding site [chemical binding]; other site 324057014471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057014472 dimer interface [polypeptide binding]; other site 324057014473 putative CheW interface [polypeptide binding]; other site 324057014474 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 324057014475 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 324057014476 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 324057014477 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 324057014478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057014479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014480 homodimer interface [polypeptide binding]; other site 324057014481 catalytic residue [active] 324057014482 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 324057014483 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 324057014484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057014485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014486 active site 324057014487 phosphorylation site [posttranslational modification] 324057014488 intermolecular recognition site; other site 324057014489 dimerization interface [polypeptide binding]; other site 324057014490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057014491 DNA binding site [nucleotide binding] 324057014492 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 324057014493 homodimer interface [polypeptide binding]; other site 324057014494 substrate-cofactor binding pocket; other site 324057014495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014496 catalytic residue [active] 324057014497 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 324057014498 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324057014499 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324057014500 glutamine synthetase, type I; Region: GlnA; TIGR00653 324057014501 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324057014502 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324057014503 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 324057014504 NeuB family; Region: NeuB; cl00496 324057014505 LytB protein; Region: LYTB; cl00507 324057014506 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 324057014507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057014508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057014509 dimerization interface [polypeptide binding]; other site 324057014510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057014511 dimer interface [polypeptide binding]; other site 324057014512 phosphorylation site [posttranslational modification] 324057014513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014514 ATP binding site [chemical binding]; other site 324057014515 Mg2+ binding site [ion binding]; other site 324057014516 G-X-G motif; other site 324057014517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057014518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014519 active site 324057014520 phosphorylation site [posttranslational modification] 324057014521 intermolecular recognition site; other site 324057014522 dimerization interface [polypeptide binding]; other site 324057014523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057014524 DNA binding site [nucleotide binding] 324057014525 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 324057014526 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057014527 protein binding site [polypeptide binding]; other site 324057014528 YugN-like family; Region: YugN; pfam08868 324057014529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057014530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014531 active site 324057014532 phosphorylation site [posttranslational modification] 324057014533 intermolecular recognition site; other site 324057014534 dimerization interface [polypeptide binding]; other site 324057014535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057014536 DNA binding residues [nucleotide binding] 324057014537 dimerization interface [polypeptide binding]; other site 324057014538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057014539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057014540 Histidine kinase; Region: HisKA_3; pfam07730 324057014541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014542 ATP binding site [chemical binding]; other site 324057014543 Mg2+ binding site [ion binding]; other site 324057014544 G-X-G motif; other site 324057014545 putative transporter; Provisional; Region: PRK03699 324057014546 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 324057014547 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 324057014548 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 324057014549 3D domain; Region: 3D; cl01439 324057014550 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 324057014551 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 324057014552 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 324057014553 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 324057014554 active site 324057014555 dimer interface [polypeptide binding]; other site 324057014556 motif 1; other site 324057014557 motif 2; other site 324057014558 motif 3; other site 324057014559 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 324057014560 anticodon binding site; other site 324057014561 YtxC-like family; Region: YtxC; cl08500 324057014562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057014563 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 324057014564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057014565 FeS/SAM binding site; other site 324057014566 cystathionine beta-lyase; Provisional; Region: PRK08064 324057014567 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057014568 homodimer interface [polypeptide binding]; other site 324057014569 substrate-cofactor binding pocket; other site 324057014570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014571 catalytic residue [active] 324057014572 cystathionine gamma-synthase; Reviewed; Region: PRK08247 324057014573 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057014574 homodimer interface [polypeptide binding]; other site 324057014575 substrate-cofactor binding pocket; other site 324057014576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014577 catalytic residue [active] 324057014578 Homoserine O-succinyltransferase; Region: HTS; pfam04204 324057014579 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 324057014580 proposed active site lysine [active] 324057014581 conserved cys residue [active] 324057014582 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324057014583 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 324057014584 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057014585 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057014586 dimer interface [polypeptide binding]; other site 324057014587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014588 catalytic residue [active] 324057014589 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 324057014590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057014591 Helix-turn-helix domains; Region: HTH; cl00088 324057014592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057014593 dimerization interface [polypeptide binding]; other site 324057014594 histidinol-phosphatase; Provisional; Region: PRK07328 324057014595 DoxX; Region: DoxX; cl00976 324057014596 Helix-turn-helix domains; Region: HTH; cl00088 324057014597 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 324057014598 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 324057014599 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057014600 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 324057014601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014602 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324057014603 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 324057014604 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 324057014605 putative Iron-sulfur protein interface [polypeptide binding]; other site 324057014606 proximal heme binding site [chemical binding]; other site 324057014607 distal heme binding site [chemical binding]; other site 324057014608 putative dimer interface [polypeptide binding]; other site 324057014609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057014610 Helix-turn-helix domains; Region: HTH; cl00088 324057014611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057014612 dimerization interface [polypeptide binding]; other site 324057014613 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324057014614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014615 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 324057014616 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324057014617 Cation transport protein; Region: TrkH; cl10514 324057014618 CAAX protease self-immunity; Region: Abi; cl00558 324057014619 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 324057014620 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 324057014621 GIY-YIG motif/motif A; other site 324057014622 active site 324057014623 catalytic site [active] 324057014624 putative DNA binding site [nucleotide binding]; other site 324057014625 metal binding site [ion binding]; metal-binding site 324057014626 UvrB/uvrC motif; Region: UVR; pfam02151 324057014627 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 324057014628 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 324057014629 DNA binding site [nucleotide binding] 324057014630 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 324057014631 sulfate transport protein; Provisional; Region: cysT; CHL00187 324057014632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014633 dimer interface [polypeptide binding]; other site 324057014634 conserved gate region; other site 324057014635 putative PBP binding loops; other site 324057014636 ABC-ATPase subunit interface; other site 324057014637 sulfate transport protein; Provisional; Region: cysT; CHL00187 324057014638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014639 dimer interface [polypeptide binding]; other site 324057014640 conserved gate region; other site 324057014641 putative PBP binding loops; other site 324057014642 ABC-ATPase subunit interface; other site 324057014643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057014644 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057014645 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 324057014646 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057014647 Walker A/P-loop; other site 324057014648 ATP binding site [chemical binding]; other site 324057014649 Q-loop/lid; other site 324057014650 ABC transporter signature motif; other site 324057014651 Walker B; other site 324057014652 D-loop; other site 324057014653 H-loop/switch region; other site 324057014654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057014655 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057014656 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057014657 Walker A/P-loop; other site 324057014658 ATP binding site [chemical binding]; other site 324057014659 Q-loop/lid; other site 324057014660 ABC transporter signature motif; other site 324057014661 Walker B; other site 324057014662 D-loop; other site 324057014663 H-loop/switch region; other site 324057014664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057014665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057014666 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324057014667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014668 dimer interface [polypeptide binding]; other site 324057014669 conserved gate region; other site 324057014670 putative PBP binding loops; other site 324057014671 ABC-ATPase subunit interface; other site 324057014672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057014673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014674 dimer interface [polypeptide binding]; other site 324057014675 conserved gate region; other site 324057014676 putative PBP binding loops; other site 324057014677 ABC-ATPase subunit interface; other site 324057014678 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324057014679 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057014680 primosomal protein DnaI; Reviewed; Region: PRK08939 324057014681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057014682 Walker A motif; other site 324057014683 ATP binding site [chemical binding]; other site 324057014684 Walker B motif; other site 324057014685 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 324057014686 Putative membrane protein; Region: YuiB; pfam14068 324057014687 Chlorite dismutase; Region: Chlor_dismutase; cl01280 324057014688 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057014689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057014690 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057014691 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057014692 Sporulation inhibitor A; Region: Sda; pfam08970 324057014693 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057014694 DNA topoisomerase III; Provisional; Region: PRK07726 324057014695 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 324057014696 active site 324057014697 putative interdomain interaction site [polypeptide binding]; other site 324057014698 putative metal-binding site [ion binding]; other site 324057014699 putative nucleotide binding site [chemical binding]; other site 324057014700 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324057014701 domain I; other site 324057014702 DNA binding groove [nucleotide binding] 324057014703 phosphate binding site [ion binding]; other site 324057014704 domain II; other site 324057014705 domain III; other site 324057014706 nucleotide binding site [chemical binding]; other site 324057014707 catalytic site [active] 324057014708 domain IV; other site 324057014709 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 324057014710 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 324057014711 putative active site [active] 324057014712 putative metal binding site [ion binding]; other site 324057014713 endonuclease subunit; Provisional; Region: 46; PHA02562 324057014714 FtsX-like permease family; Region: FtsX; cl15850 324057014715 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057014716 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057014717 Walker A/P-loop; other site 324057014718 ATP binding site [chemical binding]; other site 324057014719 Q-loop/lid; other site 324057014720 ABC transporter signature motif; other site 324057014721 Walker B; other site 324057014722 D-loop; other site 324057014723 H-loop/switch region; other site 324057014724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 324057014725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014726 ATP binding site [chemical binding]; other site 324057014727 Mg2+ binding site [ion binding]; other site 324057014728 G-X-G motif; other site 324057014729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057014730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014731 active site 324057014732 phosphorylation site [posttranslational modification] 324057014733 intermolecular recognition site; other site 324057014734 dimerization interface [polypeptide binding]; other site 324057014735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057014736 DNA binding site [nucleotide binding] 324057014737 translocation protein TolB; Provisional; Region: tolB; PRK04922 324057014738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057014739 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 324057014740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014741 dimer interface [polypeptide binding]; other site 324057014742 conserved gate region; other site 324057014743 putative PBP binding loops; other site 324057014744 ABC-ATPase subunit interface; other site 324057014745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014746 dimer interface [polypeptide binding]; other site 324057014747 conserved gate region; other site 324057014748 putative PBP binding loops; other site 324057014749 ABC-ATPase subunit interface; other site 324057014750 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 324057014751 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 324057014752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057014753 FeS/SAM binding site; other site 324057014754 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057014755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057014756 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 324057014757 NifU-like domain; Region: NifU; cl00484 324057014758 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057014759 classical (c) SDRs; Region: SDR_c; cd05233 324057014760 NAD(P) binding site [chemical binding]; other site 324057014761 active site 324057014762 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 324057014763 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 324057014764 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 324057014765 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057014766 catalytic residues [active] 324057014767 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057014768 stage V sporulation protein B; Region: spore_V_B; TIGR02900 324057014769 MatE; Region: MatE; cl10513 324057014770 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057014771 conserved cys residue [active] 324057014772 Protein of unknown function (DUF456); Region: DUF456; cl01069 324057014773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057014774 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057014775 active site 324057014776 motif I; other site 324057014777 motif II; other site 324057014778 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057014779 ABC-ATPase subunit interface; other site 324057014780 dimer interface [polypeptide binding]; other site 324057014781 putative PBP binding regions; other site 324057014782 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057014783 ABC-ATPase subunit interface; other site 324057014784 dimer interface [polypeptide binding]; other site 324057014785 putative PBP binding regions; other site 324057014786 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 324057014787 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 324057014788 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057014789 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 324057014790 intersubunit interface [polypeptide binding]; other site 324057014791 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 324057014792 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057014793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057014794 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057014795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057014797 putative substrate translocation pore; other site 324057014798 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 324057014799 active site 324057014800 metal binding site [ion binding]; metal-binding site 324057014801 Membrane transport protein; Region: Mem_trans; cl09117 324057014802 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 324057014803 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 324057014804 Cu(I) binding site [ion binding]; other site 324057014805 UbiA prenyltransferase family; Region: UbiA; cl00337 324057014806 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 324057014807 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 324057014808 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057014809 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 324057014810 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 324057014811 active site 324057014812 HIGH motif; other site 324057014813 dimer interface [polypeptide binding]; other site 324057014814 KMSKS motif; other site 324057014815 Predicted permease; Region: DUF318; pfam03773 324057014816 Predicted permeases [General function prediction only]; Region: COG0701 324057014817 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 324057014818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057014819 dimerization interface [polypeptide binding]; other site 324057014820 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057014821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057014822 dimer interface [polypeptide binding]; other site 324057014823 putative CheW interface [polypeptide binding]; other site 324057014824 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057014825 NodB motif; other site 324057014826 active site 324057014827 catalytic site [active] 324057014828 metal binding site [ion binding]; metal-binding site 324057014829 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057014830 3D domain; Region: 3D; cl01439 324057014831 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324057014832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057014833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057014835 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057014836 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 324057014837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057014838 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057014839 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 324057014840 active site residue [active] 324057014841 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 324057014842 CPxP motif; other site 324057014843 DsrE/DsrF-like family; Region: DrsE; cl00672 324057014844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057014845 dimerization interface [polypeptide binding]; other site 324057014846 putative DNA binding site [nucleotide binding]; other site 324057014847 putative Zn2+ binding site [ion binding]; other site 324057014848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057014850 putative substrate translocation pore; other site 324057014851 Cupin domain; Region: Cupin_2; cl09118 324057014852 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014854 Helix-turn-helix domains; Region: HTH; cl00088 324057014855 WHG domain; Region: WHG; pfam13305 324057014856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057014857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057014858 Coenzyme A binding pocket [chemical binding]; other site 324057014859 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 324057014860 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057014861 Phosphotransferase enzyme family; Region: APH; pfam01636 324057014862 active site 324057014863 substrate binding site [chemical binding]; other site 324057014864 ATP binding site [chemical binding]; other site 324057014865 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057014866 nudix motif; other site 324057014867 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 324057014868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057014869 motif II; other site 324057014870 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 324057014871 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 324057014872 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057014873 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057014874 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 324057014875 nudix motif; other site 324057014876 HEAT repeats; Region: HEAT_2; pfam13646 324057014877 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 324057014878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057014879 AAA domain; Region: AAA_33; pfam13671 324057014880 allophanate hydrolase; Provisional; Region: PRK08186 324057014881 Amidase; Region: Amidase; cl11426 324057014882 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057014883 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 324057014884 Helix-turn-helix domains; Region: HTH; cl00088 324057014885 Cupin domain; Region: Cupin_2; cl09118 324057014886 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 324057014887 ring-opening amidohydrolases; Region: amido_AtzD_TrzD; TIGR02714 324057014888 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057014889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057014890 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057014891 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057014892 Walker A/P-loop; other site 324057014893 ATP binding site [chemical binding]; other site 324057014894 Q-loop/lid; other site 324057014895 ABC transporter signature motif; other site 324057014896 Walker B; other site 324057014897 D-loop; other site 324057014898 H-loop/switch region; other site 324057014899 NMT1/THI5 like; Region: NMT1; pfam09084 324057014900 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057014901 substrate binding pocket [chemical binding]; other site 324057014902 membrane-bound complex binding site; other site 324057014903 hinge residues; other site 324057014904 Isochorismatase family; Region: Isochorismatase; pfam00857 324057014905 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324057014906 catalytic triad [active] 324057014907 conserved cis-peptide bond; other site 324057014908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057014909 Coenzyme A binding pocket [chemical binding]; other site 324057014910 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057014911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057014912 Coenzyme A binding pocket [chemical binding]; other site 324057014913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057014914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057014915 OsmC-like protein; Region: OsmC; cl00767 324057014916 Phosphotransferase enzyme family; Region: APH; pfam01636 324057014917 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057014918 active site 324057014919 substrate binding site [chemical binding]; other site 324057014920 ATP binding site [chemical binding]; other site 324057014921 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057014922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057014923 Predicted acetyltransferase [General function prediction only]; Region: COG3393 324057014924 Coenzyme A binding pocket [chemical binding]; other site 324057014925 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057014926 Cupin domain; Region: Cupin_2; cl09118 324057014927 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057014928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014929 Cupin domain; Region: Cupin_2; cl09118 324057014930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014931 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057014932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014933 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057014934 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057014935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057014936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014937 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057014938 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057014939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014940 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057014941 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324057014942 amidase catalytic site [active] 324057014943 Zn binding residues [ion binding]; other site 324057014944 substrate binding site [chemical binding]; other site 324057014945 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057014946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057014947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014948 active site 324057014949 phosphorylation site [posttranslational modification] 324057014950 intermolecular recognition site; other site 324057014951 dimerization interface [polypeptide binding]; other site 324057014952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057014953 DNA binding residues [nucleotide binding] 324057014954 dimerization interface [polypeptide binding]; other site 324057014955 GAF domain; Region: GAF_2; pfam13185 324057014956 GAF domain; Region: GAF; cl15785 324057014957 GAF domain; Region: GAF_2; pfam13185 324057014958 Histidine kinase; Region: HisKA_3; pfam07730 324057014959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014960 ATP binding site [chemical binding]; other site 324057014961 Mg2+ binding site [ion binding]; other site 324057014962 G-X-G motif; other site 324057014963 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 324057014964 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 324057014965 WYL domain; Region: WYL; cl14852 324057014966 enoyl-CoA hydratase; Provisional; Region: PRK05981 324057014967 WYL domain; Region: WYL; cl14852 324057014968 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324057014969 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324057014970 dimer interface [polypeptide binding]; other site 324057014971 active site 324057014972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057014973 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 324057014974 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 324057014975 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 324057014976 putative active site [active] 324057014977 putative metal binding site [ion binding]; other site 324057014978 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057014979 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057014980 translocation protein TolB; Provisional; Region: tolB; PRK02889 324057014981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057014982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057014983 dimer interface [polypeptide binding]; other site 324057014984 phosphorylation site [posttranslational modification] 324057014985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014986 ATP binding site [chemical binding]; other site 324057014987 Mg2+ binding site [ion binding]; other site 324057014988 G-X-G motif; other site 324057014989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057014990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014991 active site 324057014992 phosphorylation site [posttranslational modification] 324057014993 intermolecular recognition site; other site 324057014994 dimerization interface [polypeptide binding]; other site 324057014995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057014996 DNA binding site [nucleotide binding] 324057014997 hypothetical protein; Provisional; Region: PRK04351 324057014998 SprT homologues; Region: SprT; cl01182 324057014999 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324057015000 dimer interface [polypeptide binding]; other site 324057015001 FMN binding site [chemical binding]; other site 324057015002 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057015003 Helix-turn-helix domains; Region: HTH; cl00088 324057015004 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 324057015005 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 324057015006 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 324057015007 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 324057015008 RNA binding site [nucleotide binding]; other site 324057015009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057015010 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 324057015011 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057015012 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 324057015013 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 324057015014 S-layer homology domain; Region: SLH; pfam00395 324057015015 Small acid-soluble spore protein H family; Region: SspH; cl06949 324057015016 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 324057015017 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 324057015018 putative DNA binding site [nucleotide binding]; other site 324057015019 putative homodimer interface [polypeptide binding]; other site 324057015020 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 324057015021 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 324057015022 active site 324057015023 DNA binding site [nucleotide binding] 324057015024 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 324057015025 DNA binding site [nucleotide binding] 324057015026 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 324057015027 nucleotide binding site [chemical binding]; other site 324057015028 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 324057015029 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 324057015030 putative active site [active] 324057015031 catalytic site [active] 324057015032 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 324057015033 putative active site [active] 324057015034 catalytic site [active] 324057015035 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 324057015036 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 324057015037 NADP binding site [chemical binding]; other site 324057015038 active site 324057015039 putative substrate binding site [chemical binding]; other site 324057015040 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 324057015041 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 324057015042 NAD binding site [chemical binding]; other site 324057015043 substrate binding site [chemical binding]; other site 324057015044 homodimer interface [polypeptide binding]; other site 324057015045 active site 324057015046 Cupin domain; Region: Cupin_2; cl09118 324057015047 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 324057015048 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057015049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057015050 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 324057015051 Walker A/P-loop; other site 324057015052 ATP binding site [chemical binding]; other site 324057015053 Q-loop/lid; other site 324057015054 ABC transporter signature motif; other site 324057015055 Walker B; other site 324057015056 D-loop; other site 324057015057 H-loop/switch region; other site 324057015058 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324057015059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057015060 active site 324057015061 Cupin domain; Region: Cupin_2; cl09118 324057015062 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057015063 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057015064 PilZ domain; Region: PilZ; cl01260 324057015065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057015066 non-specific DNA binding site [nucleotide binding]; other site 324057015067 salt bridge; other site 324057015068 sequence-specific DNA binding site [nucleotide binding]; other site 324057015069 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 324057015070 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 324057015071 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 324057015072 active site 324057015073 dimer interface [polypeptide binding]; other site 324057015074 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 324057015075 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 324057015076 active site 324057015077 FMN binding site [chemical binding]; other site 324057015078 substrate binding site [chemical binding]; other site 324057015079 3Fe-4S cluster binding site [ion binding]; other site 324057015080 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 324057015081 domain interface; other site 324057015082 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057015083 active site 324057015084 catalytic triad [active] 324057015085 oxyanion hole [active] 324057015086 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015087 Kinase associated protein B; Region: KapB; pfam08810 324057015088 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 324057015089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057015090 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057015091 Malic enzyme, N-terminal domain; Region: malic; pfam00390 324057015092 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 324057015093 putative NAD(P) binding site [chemical binding]; other site 324057015094 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324057015095 OpgC protein; Region: OpgC_C; cl00792 324057015096 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 324057015097 putative active site [active] 324057015098 putative metal binding site [ion binding]; other site 324057015099 OpgC protein; Region: OpgC_C; cl00792 324057015100 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324057015101 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057015102 Cation efflux family; Region: Cation_efflux; cl00316 324057015103 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 324057015104 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057015105 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057015106 ABC transporter; Region: ABC_tran_2; pfam12848 324057015107 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 324057015108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015110 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057015111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057015112 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 324057015113 Virulence factor; Region: Virulence_fact; pfam13769 324057015114 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 324057015115 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 324057015116 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 324057015117 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057015118 Sulfatase; Region: Sulfatase; cl10460 324057015119 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057015120 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057015121 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057015122 Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F; Region: GH_F; cd08978 324057015123 active site 324057015124 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015126 dimer interface [polypeptide binding]; other site 324057015127 conserved gate region; other site 324057015128 putative PBP binding loops; other site 324057015129 ABC-ATPase subunit interface; other site 324057015130 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015132 dimer interface [polypeptide binding]; other site 324057015133 conserved gate region; other site 324057015134 putative PBP binding loops; other site 324057015135 ABC-ATPase subunit interface; other site 324057015136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015138 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057015139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057015140 dimerization interface [polypeptide binding]; other site 324057015141 putative DNA binding site [nucleotide binding]; other site 324057015142 putative Zn2+ binding site [ion binding]; other site 324057015143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057015144 Helix-turn-helix domains; Region: HTH; cl00088 324057015145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057015146 dimerization interface [polypeptide binding]; other site 324057015147 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057015148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057015149 Helix-turn-helix domains; Region: HTH; cl00088 324057015150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015151 Coenzyme A binding pocket [chemical binding]; other site 324057015152 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057015153 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057015154 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 324057015155 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 324057015156 active site 324057015157 catalytic residues [active] 324057015158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057015159 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015161 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057015162 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057015163 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057015164 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015166 dimer interface [polypeptide binding]; other site 324057015167 conserved gate region; other site 324057015168 putative PBP binding loops; other site 324057015169 ABC-ATPase subunit interface; other site 324057015170 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015172 dimer interface [polypeptide binding]; other site 324057015173 conserved gate region; other site 324057015174 putative PBP binding loops; other site 324057015175 ABC-ATPase subunit interface; other site 324057015176 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015178 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 324057015179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057015180 DNA-binding site [nucleotide binding]; DNA binding site 324057015181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057015182 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057015183 dimerization interface [polypeptide binding]; other site 324057015184 ligand binding site [chemical binding]; other site 324057015185 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 324057015186 NADP binding site [chemical binding]; other site 324057015187 homodimer interface [polypeptide binding]; other site 324057015188 active site 324057015189 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 324057015190 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057015191 putative metal binding site [ion binding]; other site 324057015192 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057015193 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057015194 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057015195 putative metal binding site [ion binding]; other site 324057015196 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 324057015197 S-layer homology domain; Region: SLH; pfam00395 324057015198 S-layer homology domain; Region: SLH; pfam00395 324057015199 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015200 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057015201 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057015203 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057015205 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015207 active site 324057015208 phosphorylation site [posttranslational modification] 324057015209 intermolecular recognition site; other site 324057015210 dimerization interface [polypeptide binding]; other site 324057015211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057015214 Histidine kinase; Region: His_kinase; pfam06580 324057015215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057015216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057015217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057015218 DNA binding site [nucleotide binding] 324057015219 domain linker motif; other site 324057015220 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057015221 dimerization interface [polypeptide binding]; other site 324057015222 ligand binding site [chemical binding]; other site 324057015223 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057015224 conserved cys residue [active] 324057015225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015226 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015227 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057015228 Cupin domain; Region: Cupin_2; cl09118 324057015229 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015231 Sensory domain found in PocR; Region: PocR; pfam10114 324057015232 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 324057015233 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015235 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 324057015236 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 324057015237 dimer interface [polypeptide binding]; other site 324057015238 active site 324057015239 metal binding site [ion binding]; metal-binding site 324057015240 dihydroxyacetone kinase; Provisional; Region: PRK14479 324057015241 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 324057015242 DAK2 domain; Region: Dak2; cl03685 324057015243 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 324057015244 classical (c) SDRs; Region: SDR_c; cd05233 324057015245 NAD(P) binding site [chemical binding]; other site 324057015246 active site 324057015247 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057015248 active site 324057015249 catalytic residues [active] 324057015250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057015251 TPR motif; other site 324057015252 binding surface 324057015253 TPR repeat; Region: TPR_11; pfam13414 324057015254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057015255 binding surface 324057015256 TPR motif; other site 324057015257 Cupin domain; Region: Cupin_2; cl09118 324057015258 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057015259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015260 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 324057015261 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057015262 Sulfatase; Region: Sulfatase; cl10460 324057015263 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015265 active site 324057015266 phosphorylation site [posttranslational modification] 324057015267 intermolecular recognition site; other site 324057015268 dimerization interface [polypeptide binding]; other site 324057015269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015271 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057015272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015273 dimerization interface [polypeptide binding]; other site 324057015274 Histidine kinase; Region: His_kinase; pfam06580 324057015275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015276 ATP binding site [chemical binding]; other site 324057015277 Mg2+ binding site [ion binding]; other site 324057015278 G-X-G motif; other site 324057015279 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015280 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015282 dimer interface [polypeptide binding]; other site 324057015283 conserved gate region; other site 324057015284 putative PBP binding loops; other site 324057015285 ABC-ATPase subunit interface; other site 324057015286 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015288 dimer interface [polypeptide binding]; other site 324057015289 conserved gate region; other site 324057015290 ABC-ATPase subunit interface; other site 324057015291 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057015292 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057015293 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057015294 Cupin domain; Region: Cupin_2; cl09118 324057015295 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 324057015296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015297 Histidine kinase; Region: His_kinase; pfam06580 324057015298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015299 ATP binding site [chemical binding]; other site 324057015300 Mg2+ binding site [ion binding]; other site 324057015301 G-X-G motif; other site 324057015302 Response regulator receiver domain; Region: Response_reg; pfam00072 324057015303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015304 active site 324057015305 phosphorylation site [posttranslational modification] 324057015306 intermolecular recognition site; other site 324057015307 dimerization interface [polypeptide binding]; other site 324057015308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015310 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 324057015311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015312 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015314 dimer interface [polypeptide binding]; other site 324057015315 conserved gate region; other site 324057015316 putative PBP binding loops; other site 324057015317 ABC-ATPase subunit interface; other site 324057015318 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015320 dimer interface [polypeptide binding]; other site 324057015321 conserved gate region; other site 324057015322 putative PBP binding loops; other site 324057015323 ABC-ATPase subunit interface; other site 324057015324 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 324057015325 active site 324057015326 FMN binding site [chemical binding]; other site 324057015327 substrate binding site [chemical binding]; other site 324057015328 homotetramer interface [polypeptide binding]; other site 324057015329 catalytic residue [active] 324057015330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057015331 Helix-turn-helix domains; Region: HTH; cl00088 324057015332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057015333 Right handed beta helix region; Region: Beta_helix; pfam13229 324057015334 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057015335 sugar binding site [chemical binding]; other site 324057015336 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057015337 sugar binding site [chemical binding]; other site 324057015338 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057015339 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324057015340 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057015341 sugar binding site [chemical binding]; other site 324057015342 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057015343 sugar binding site [chemical binding]; other site 324057015344 S-layer homology domain; Region: SLH; pfam00395 324057015345 S-layer homology domain; Region: SLH; pfam00395 324057015346 S-layer homology domain; Region: SLH; pfam00395 324057015347 Domain of unknown function (DUF377); Region: DUF377; pfam04041 324057015348 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057015349 active site 324057015350 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015352 dimer interface [polypeptide binding]; other site 324057015353 conserved gate region; other site 324057015354 putative PBP binding loops; other site 324057015355 ABC-ATPase subunit interface; other site 324057015356 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057015357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015358 dimer interface [polypeptide binding]; other site 324057015359 conserved gate region; other site 324057015360 putative PBP binding loops; other site 324057015361 ABC-ATPase subunit interface; other site 324057015362 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057015365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015366 dimerization interface [polypeptide binding]; other site 324057015367 Histidine kinase; Region: His_kinase; pfam06580 324057015368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015369 ATP binding site [chemical binding]; other site 324057015370 Mg2+ binding site [ion binding]; other site 324057015371 G-X-G motif; other site 324057015372 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015374 active site 324057015375 phosphorylation site [posttranslational modification] 324057015376 intermolecular recognition site; other site 324057015377 dimerization interface [polypeptide binding]; other site 324057015378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015379 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057015380 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057015381 Helix-turn-helix domains; Region: HTH; cl00088 324057015382 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015384 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057015385 NAD(P) binding site [chemical binding]; other site 324057015386 active site 324057015387 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057015388 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057015389 Spore germination protein; Region: Spore_permease; cl15802 324057015390 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057015391 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057015392 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057015393 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 324057015394 Cupin domain; Region: Cupin_2; cl09118 324057015395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015396 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015398 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057015399 Helix-turn-helix domains; Region: HTH; cl00088 324057015400 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 324057015401 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 324057015402 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057015403 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057015404 Walker A/P-loop; other site 324057015405 ATP binding site [chemical binding]; other site 324057015406 Q-loop/lid; other site 324057015407 ABC transporter signature motif; other site 324057015408 Walker B; other site 324057015409 D-loop; other site 324057015410 H-loop/switch region; other site 324057015411 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057015412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015413 dimer interface [polypeptide binding]; other site 324057015414 conserved gate region; other site 324057015415 putative PBP binding loops; other site 324057015416 ABC-ATPase subunit interface; other site 324057015417 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057015418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015420 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015422 dimer interface [polypeptide binding]; other site 324057015423 putative PBP binding loops; other site 324057015424 ABC-ATPase subunit interface; other site 324057015425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015427 dimer interface [polypeptide binding]; other site 324057015428 conserved gate region; other site 324057015429 putative PBP binding loops; other site 324057015430 ABC-ATPase subunit interface; other site 324057015431 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015433 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015435 active site 324057015436 phosphorylation site [posttranslational modification] 324057015437 intermolecular recognition site; other site 324057015438 dimerization interface [polypeptide binding]; other site 324057015439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015441 Histidine kinase; Region: His_kinase; pfam06580 324057015442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015443 ATP binding site [chemical binding]; other site 324057015444 Mg2+ binding site [ion binding]; other site 324057015445 G-X-G motif; other site 324057015446 cystathionine beta-lyase; Provisional; Region: PRK07671 324057015447 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057015448 homodimer interface [polypeptide binding]; other site 324057015449 substrate-cofactor binding pocket; other site 324057015450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015451 catalytic residue [active] 324057015452 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057015453 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057015454 dimer interface [polypeptide binding]; other site 324057015455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015456 catalytic residue [active] 324057015457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057015458 S-adenosylmethionine binding site [chemical binding]; other site 324057015459 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 324057015460 putative active site [active] 324057015461 catalytic site [active] 324057015462 putative metal binding site [ion binding]; other site 324057015463 Probable beta-xylosidase; Provisional; Region: PLN03080 324057015464 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057015465 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057015466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 324057015467 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324057015468 Cupin domain; Region: Cupin_2; cl09118 324057015469 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015470 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057015471 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057015472 dockerin binding interface; other site 324057015473 S-layer homology domain; Region: SLH; pfam00395 324057015474 S-layer homology domain; Region: SLH; pfam00395 324057015475 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057015476 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057015477 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057015478 Probable beta-xylosidase; Provisional; Region: PLN03080 324057015479 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057015480 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057015481 metal binding site [ion binding]; metal-binding site 324057015482 ligand binding site [chemical binding]; other site 324057015483 Cadherin repeat-like domain; Region: CA_like; cl15786 324057015484 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057015485 dockerin binding interface; other site 324057015486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015488 Helix-turn-helix domains; Region: HTH; cl00088 324057015489 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 324057015490 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 324057015491 active site 324057015492 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 324057015493 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015494 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324057015495 Helix-turn-helix domains; Region: HTH; cl00088 324057015496 AsnC family; Region: AsnC_trans_reg; pfam01037 324057015497 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057015498 Cation efflux family; Region: Cation_efflux; cl00316 324057015499 putative oxidoreductase; Provisional; Region: PRK11579 324057015500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015501 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057015502 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057015503 Helix-turn-helix domains; Region: HTH; cl00088 324057015504 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057015505 Cupin domain; Region: Cupin_2; cl09118 324057015506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015508 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057015509 Beta-galactosidase, domain 2; Region: BetaGal_dom2; cl11086 324057015510 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057015511 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057015512 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057015513 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 324057015514 putative NAD(P) binding site [chemical binding]; other site 324057015515 Cupin domain; Region: Cupin_2; cl09118 324057015516 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015518 AAA domain; Region: AAA_33; pfam13671 324057015519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057015520 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057015521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057015522 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057015523 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 324057015524 Walker A/P-loop; other site 324057015525 ATP binding site [chemical binding]; other site 324057015526 Q-loop/lid; other site 324057015527 ABC transporter signature motif; other site 324057015528 Walker B; other site 324057015529 D-loop; other site 324057015530 H-loop/switch region; other site 324057015531 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057015532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057015533 ABC-ATPase subunit interface; other site 324057015534 dimer interface [polypeptide binding]; other site 324057015535 putative PBP binding regions; other site 324057015536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 324057015537 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057015538 putative PBP binding regions; other site 324057015539 ABC-ATPase subunit interface; other site 324057015540 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057015541 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057015542 siderophore binding site; other site 324057015543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015544 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057015545 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057015546 intersubunit interface [polypeptide binding]; other site 324057015547 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057015548 beta-D-glucuronidase; Provisional; Region: PRK10150 324057015549 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057015550 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057015551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015553 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057015554 Helix-turn-helix domains; Region: HTH; cl00088 324057015555 WYL domain; Region: WYL; cl14852 324057015556 EamA-like transporter family; Region: EamA; cl01037 324057015557 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057015558 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 324057015559 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 324057015560 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 324057015561 active site 324057015562 intersubunit interface [polypeptide binding]; other site 324057015563 catalytic residue [active] 324057015564 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 324057015565 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324057015566 minor groove reading motif; other site 324057015567 helix-hairpin-helix signature motif; other site 324057015568 substrate binding pocket [chemical binding]; other site 324057015569 active site 324057015570 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 324057015571 DNA binding and oxoG recognition site [nucleotide binding] 324057015572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015573 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015575 Cytochrome c; Region: Cytochrom_C; cl11414 324057015576 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 324057015577 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 324057015578 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 324057015579 homodimer interface [polypeptide binding]; other site 324057015580 NAD binding pocket [chemical binding]; other site 324057015581 ATP binding pocket [chemical binding]; other site 324057015582 Mg binding site [ion binding]; other site 324057015583 active-site loop [active] 324057015584 Disulphide isomerase; Region: Disulph_isomer; cl05813 324057015585 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 324057015586 sensory histidine kinase AtoS; Provisional; Region: PRK11360 324057015587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057015588 dimer interface [polypeptide binding]; other site 324057015589 phosphorylation site [posttranslational modification] 324057015590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015591 ATP binding site [chemical binding]; other site 324057015592 Mg2+ binding site [ion binding]; other site 324057015593 G-X-G motif; other site 324057015594 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 324057015595 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057015596 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057015597 HI0933-like protein; Region: HI0933_like; pfam03486 324057015598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015599 PAS domain; Region: PAS_9; pfam13426 324057015600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057015601 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 324057015602 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 324057015603 DNA binding residues [nucleotide binding] 324057015604 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 324057015605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015606 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 324057015607 homotrimer interaction site [polypeptide binding]; other site 324057015608 putative active site [active] 324057015609 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 324057015610 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 324057015611 N- and C-terminal domain interface [polypeptide binding]; other site 324057015612 D-xylulose kinase; Region: XylB; TIGR01312 324057015613 active site 324057015614 catalytic site [active] 324057015615 metal binding site [ion binding]; metal-binding site 324057015616 xylulose binding site [chemical binding]; other site 324057015617 putative ATP binding site [chemical binding]; other site 324057015618 homodimer interface [polypeptide binding]; other site 324057015619 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 324057015620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057015621 non-specific DNA binding site [nucleotide binding]; other site 324057015622 salt bridge; other site 324057015623 sequence-specific DNA binding site [nucleotide binding]; other site 324057015624 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 324057015625 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057015626 active site 324057015627 Haemolysin XhlA; Region: XhlA; pfam10779 324057015628 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 324057015629 kelch-like protein; Provisional; Region: PHA03098 324057015630 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 324057015631 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 324057015632 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 324057015633 Baseplate J-like protein; Region: Baseplate_J; cl01294 324057015634 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 324057015635 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 324057015636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 324057015637 tape measure domain; Region: tape_meas_nterm; TIGR02675 324057015638 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324057015639 Phage XkdN-like protein; Region: XkdN; pfam08890 324057015640 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 324057015641 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 324057015642 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 324057015643 ECF sigma factor; Region: Sigma70_ECF; pfam07638 324057015644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057015645 non-specific DNA binding site [nucleotide binding]; other site 324057015646 salt bridge; other site 324057015647 sequence-specific DNA binding site [nucleotide binding]; other site 324057015648 Helix-turn-helix domains; Region: HTH; cl00088 324057015649 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057015650 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057015651 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057015652 S-layer homology domain; Region: SLH; pfam00395 324057015653 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057015654 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057015655 metal binding site [ion binding]; metal-binding site 324057015656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057015658 putative substrate translocation pore; other site 324057015659 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 324057015660 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 324057015661 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 324057015662 active site 324057015663 catalytic residues [active] 324057015664 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 324057015665 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 324057015666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015667 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 324057015668 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057015669 dimer interface [polypeptide binding]; other site 324057015670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015671 catalytic residue [active] 324057015672 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 324057015673 AMP-binding enzyme; Region: AMP-binding; cl15778 324057015674 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057015675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057015676 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057015677 Walker A/P-loop; other site 324057015678 ATP binding site [chemical binding]; other site 324057015679 Q-loop/lid; other site 324057015680 ABC transporter signature motif; other site 324057015681 Walker B; other site 324057015682 D-loop; other site 324057015683 H-loop/switch region; other site 324057015684 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 324057015685 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 324057015686 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 324057015687 putative NADP binding site [chemical binding]; other site 324057015688 putative dimer interface [polypeptide binding]; other site 324057015689 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 324057015690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057015691 Helix-turn-helix domains; Region: HTH; cl00088 324057015692 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 324057015693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015694 dimerization interface [polypeptide binding]; other site 324057015695 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 324057015696 glycogen binding site [chemical binding]; other site 324057015697 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324057015698 maltodextrin glucosidase; Provisional; Region: PRK10785 324057015699 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324057015700 active site 324057015701 homodimer interface [polypeptide binding]; other site 324057015702 catalytic site [active] 324057015703 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 324057015704 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057015705 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057015706 S-layer homology domain; Region: SLH; pfam00395 324057015707 S-layer homology domain; Region: SLH; pfam00395 324057015708 S-layer homology domain; Region: SLH; pfam00395 324057015709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 324057015710 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057015711 Cupin domain; Region: Cupin_2; cl09118 324057015712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015716 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057015717 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057015719 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057015720 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057015721 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057015722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015724 Cupin domain; Region: Cupin_2; cl09118 324057015725 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057015726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015727 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 324057015728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057015729 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 324057015730 putative substrate binding site [chemical binding]; other site 324057015731 putative ATP binding site [chemical binding]; other site 324057015732 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057015733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057015734 DNA binding site [nucleotide binding] 324057015735 domain linker motif; other site 324057015736 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 324057015737 dimerization interface [polypeptide binding]; other site 324057015738 ligand binding site [chemical binding]; other site 324057015739 sodium binding site [ion binding]; other site 324057015740 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015742 dimer interface [polypeptide binding]; other site 324057015743 conserved gate region; other site 324057015744 ABC-ATPase subunit interface; other site 324057015745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015746 dimer interface [polypeptide binding]; other site 324057015747 conserved gate region; other site 324057015748 putative PBP binding loops; other site 324057015749 ABC-ATPase subunit interface; other site 324057015750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015751 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 324057015752 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324057015753 substrate binding [chemical binding]; other site 324057015754 active site 324057015755 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324057015756 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057015757 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057015758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015759 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057015760 putative substrate translocation pore; other site 324057015761 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 324057015762 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057015763 Walker A/P-loop; other site 324057015764 ATP binding site [chemical binding]; other site 324057015765 Q-loop/lid; other site 324057015766 ABC transporter signature motif; other site 324057015767 Walker B; other site 324057015768 D-loop; other site 324057015769 H-loop/switch region; other site 324057015770 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057015771 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057015772 Walker A/P-loop; other site 324057015773 ATP binding site [chemical binding]; other site 324057015774 Q-loop/lid; other site 324057015775 ABC transporter signature motif; other site 324057015776 Walker B; other site 324057015777 D-loop; other site 324057015778 H-loop/switch region; other site 324057015779 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057015780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057015781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015782 dimer interface [polypeptide binding]; other site 324057015783 conserved gate region; other site 324057015784 ABC-ATPase subunit interface; other site 324057015785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057015786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015787 dimer interface [polypeptide binding]; other site 324057015788 conserved gate region; other site 324057015789 putative PBP binding loops; other site 324057015790 ABC-ATPase subunit interface; other site 324057015791 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 324057015792 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057015793 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057015794 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057015795 active site 324057015796 non-prolyl cis peptide bond; other site 324057015797 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057015798 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 324057015799 metal binding site [ion binding]; metal-binding site 324057015800 dimer interface [polypeptide binding]; other site 324057015801 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057015802 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057015803 active site 324057015804 non-prolyl cis peptide bond; other site 324057015805 DinB superfamily; Region: DinB_2; pfam12867 324057015806 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057015807 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 324057015808 amidohydrolase; Region: amidohydrolases; TIGR01891 324057015809 metal binding site [ion binding]; metal-binding site 324057015810 dimer interface [polypeptide binding]; other site 324057015811 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057015812 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 324057015813 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057015814 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 324057015815 Walker A/P-loop; other site 324057015816 ATP binding site [chemical binding]; other site 324057015817 Q-loop/lid; other site 324057015818 ABC transporter signature motif; other site 324057015819 Walker B; other site 324057015820 D-loop; other site 324057015821 H-loop/switch region; other site 324057015822 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324057015823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015824 dimer interface [polypeptide binding]; other site 324057015825 conserved gate region; other site 324057015826 putative PBP binding loops; other site 324057015827 ABC-ATPase subunit interface; other site 324057015828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015829 dimer interface [polypeptide binding]; other site 324057015830 conserved gate region; other site 324057015831 putative PBP binding loops; other site 324057015832 ABC-ATPase subunit interface; other site 324057015833 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057015834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057015835 substrate binding pocket [chemical binding]; other site 324057015836 membrane-bound complex binding site; other site 324057015837 hinge residues; other site 324057015838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057015839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015840 Coenzyme A binding pocket [chemical binding]; other site 324057015841 Helix-turn-helix domains; Region: HTH; cl00088 324057015842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057015843 dimerization interface [polypeptide binding]; other site 324057015844 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057015845 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057015846 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057015847 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057015848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015850 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015852 dimer interface [polypeptide binding]; other site 324057015853 conserved gate region; other site 324057015854 putative PBP binding loops; other site 324057015855 ABC-ATPase subunit interface; other site 324057015856 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015858 dimer interface [polypeptide binding]; other site 324057015859 conserved gate region; other site 324057015860 putative PBP binding loops; other site 324057015861 ABC-ATPase subunit interface; other site 324057015862 Response regulator receiver domain; Region: Response_reg; pfam00072 324057015863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015864 active site 324057015865 phosphorylation site [posttranslational modification] 324057015866 intermolecular recognition site; other site 324057015867 dimerization interface [polypeptide binding]; other site 324057015868 response regulator; Provisional; Region: PRK13435 324057015869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057015873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015874 dimerization interface [polypeptide binding]; other site 324057015875 Histidine kinase; Region: His_kinase; pfam06580 324057015876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015877 ATP binding site [chemical binding]; other site 324057015878 Mg2+ binding site [ion binding]; other site 324057015879 G-X-G motif; other site 324057015880 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057015881 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 324057015882 active site 324057015883 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057015884 sugar binding site [chemical binding]; other site 324057015885 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324057015886 active site 324057015887 multimer interface [polypeptide binding]; other site 324057015888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057015889 PAS domain; Region: PAS_9; pfam13426 324057015890 putative active site [active] 324057015891 heme pocket [chemical binding]; other site 324057015892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057015893 Histidine kinase; Region: HisKA_3; pfam07730 324057015894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015895 ATP binding site [chemical binding]; other site 324057015896 Mg2+ binding site [ion binding]; other site 324057015897 G-X-G motif; other site 324057015898 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057015899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015900 active site 324057015901 phosphorylation site [posttranslational modification] 324057015902 intermolecular recognition site; other site 324057015903 dimerization interface [polypeptide binding]; other site 324057015904 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057015905 DNA binding residues [nucleotide binding] 324057015906 dimerization interface [polypeptide binding]; other site 324057015907 GAF domain; Region: GAF; cl15785 324057015908 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324057015909 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324057015910 ligand binding site [chemical binding]; other site 324057015911 flexible hinge region; other site 324057015912 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 324057015913 putative switch regulator; other site 324057015914 non-specific DNA interactions [nucleotide binding]; other site 324057015915 DNA binding site [nucleotide binding] 324057015916 sequence specific DNA binding site [nucleotide binding]; other site 324057015917 putative cAMP binding site [chemical binding]; other site 324057015918 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 324057015919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057015920 FeS/SAM binding site; other site 324057015921 Pyruvate formate lyase 1; Region: PFL1; cd01678 324057015922 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 324057015923 coenzyme A binding site [chemical binding]; other site 324057015924 active site 324057015925 catalytic residues [active] 324057015926 glycine loop; other site 324057015927 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 324057015928 GTP binding site; other site 324057015929 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057015930 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 324057015931 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015934 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057015936 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015938 dimer interface [polypeptide binding]; other site 324057015939 conserved gate region; other site 324057015940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057015941 ABC-ATPase subunit interface; other site 324057015942 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057015943 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 324057015944 Helix-turn-helix domains; Region: HTH; cl00088 324057015945 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 324057015946 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 324057015947 active site 324057015948 catalytic triad [active] 324057015949 oxyanion hole [active] 324057015950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057015951 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324057015952 FeS/SAM binding site; other site 324057015953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057015954 PAS domain; Region: PAS_9; pfam13426 324057015955 putative active site [active] 324057015956 heme pocket [chemical binding]; other site 324057015957 PAS fold; Region: PAS_4; pfam08448 324057015958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057015959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057015960 dimer interface [polypeptide binding]; other site 324057015961 phosphorylation site [posttranslational modification] 324057015962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015963 ATP binding site [chemical binding]; other site 324057015964 Mg2+ binding site [ion binding]; other site 324057015965 G-X-G motif; other site 324057015966 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057015967 AP (apurinic/apyrimidinic) site pocket; other site 324057015968 Metal-binding active site; metal-binding site 324057015969 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015971 active site 324057015972 phosphorylation site [posttranslational modification] 324057015973 intermolecular recognition site; other site 324057015974 dimerization interface [polypeptide binding]; other site 324057015975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057015977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057015978 Histidine kinase; Region: His_kinase; pfam06580 324057015979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057015980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057015981 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057015982 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057015983 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 324057015984 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057015985 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057015986 S-layer homology domain; Region: SLH; pfam00395 324057015987 S-layer homology domain; Region: SLH; pfam00395 324057015988 S-layer homology domain; Region: SLH; pfam00395 324057015989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015991 dimer interface [polypeptide binding]; other site 324057015992 conserved gate region; other site 324057015993 putative PBP binding loops; other site 324057015994 ABC-ATPase subunit interface; other site 324057015995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015996 dimer interface [polypeptide binding]; other site 324057015997 conserved gate region; other site 324057015998 putative PBP binding loops; other site 324057015999 ABC-ATPase subunit interface; other site 324057016000 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016002 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 324057016003 putative active site [active] 324057016004 putative catalytic site [active] 324057016005 putative alpha-glucosidase; Provisional; Region: PRK10658 324057016006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016007 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057016008 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016009 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057016010 Ca binding site [ion binding]; other site 324057016011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016013 DNA binding site [nucleotide binding] 324057016014 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057016015 dimerization interface [polypeptide binding]; other site 324057016016 ligand binding site [chemical binding]; other site 324057016017 DoxX; Region: DoxX; cl00976 324057016018 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 324057016019 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057016020 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 324057016021 RDD family; Region: RDD; cl00746 324057016022 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 324057016023 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 324057016024 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057016025 metal ion-dependent adhesion site (MIDAS); other site 324057016026 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057016027 nudix motif; other site 324057016028 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057016029 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324057016030 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057016031 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 324057016032 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 324057016033 Walker A/P-loop; other site 324057016034 ATP binding site [chemical binding]; other site 324057016035 Q-loop/lid; other site 324057016036 ABC transporter signature motif; other site 324057016037 Walker B; other site 324057016038 D-loop; other site 324057016039 H-loop/switch region; other site 324057016040 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 324057016041 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 324057016042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057016043 Walker A/P-loop; other site 324057016044 ATP binding site [chemical binding]; other site 324057016045 Q-loop/lid; other site 324057016046 ABC transporter signature motif; other site 324057016047 Walker B; other site 324057016048 D-loop; other site 324057016049 H-loop/switch region; other site 324057016050 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057016051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057016052 DNA-binding site [nucleotide binding]; DNA binding site 324057016053 Protein of unknown function (DUF420); Region: DUF420; cl00989 324057016054 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 324057016055 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 324057016056 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 324057016057 Subunit I/III interface [polypeptide binding]; other site 324057016058 Subunit III/IV interface [polypeptide binding]; other site 324057016059 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 324057016060 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 324057016061 D-pathway; other site 324057016062 Putative ubiquinol binding site [chemical binding]; other site 324057016063 Low-spin heme (heme b) binding site [chemical binding]; other site 324057016064 Putative water exit pathway; other site 324057016065 Binuclear center (heme o3/CuB) [ion binding]; other site 324057016066 K-pathway; other site 324057016067 Putative proton exit pathway; other site 324057016068 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 324057016069 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057016070 Cytochrome c; Region: Cytochrom_C; cl11414 324057016071 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 324057016072 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057016073 MFS_1 like family; Region: MFS_1_like; pfam12832 324057016074 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 324057016075 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057016076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057016077 active site 324057016078 catalytic tetrad [active] 324057016079 Helix-turn-helix domains; Region: HTH; cl00088 324057016080 Spore germination protein; Region: Spore_permease; cl15802 324057016081 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057016082 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057016083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016085 dimer interface [polypeptide binding]; other site 324057016086 conserved gate region; other site 324057016087 ABC-ATPase subunit interface; other site 324057016088 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016090 dimer interface [polypeptide binding]; other site 324057016091 conserved gate region; other site 324057016092 putative PBP binding loops; other site 324057016093 ABC-ATPase subunit interface; other site 324057016094 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016095 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016097 active site 324057016098 phosphorylation site [posttranslational modification] 324057016099 intermolecular recognition site; other site 324057016100 dimerization interface [polypeptide binding]; other site 324057016101 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016102 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016103 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057016104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057016105 Histidine kinase; Region: His_kinase; pfam06580 324057016106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016107 ATP binding site [chemical binding]; other site 324057016108 Mg2+ binding site [ion binding]; other site 324057016109 G-X-G motif; other site 324057016110 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016112 active site 324057016113 phosphorylation site [posttranslational modification] 324057016114 intermolecular recognition site; other site 324057016115 dimerization interface [polypeptide binding]; other site 324057016116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016117 Cupin domain; Region: Cupin_2; cl09118 324057016118 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016120 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324057016121 dimerization interface [polypeptide binding]; other site 324057016122 active site 324057016123 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057016124 metal-binding site [ion binding] 324057016125 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 324057016126 putative homodimer interface [polypeptide binding]; other site 324057016127 putative homotetramer interface [polypeptide binding]; other site 324057016128 allosteric switch controlling residues; other site 324057016129 putative metal binding site [ion binding]; other site 324057016130 putative homodimer-homodimer interface [polypeptide binding]; other site 324057016131 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 324057016132 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 324057016133 active site 324057016134 catalytic site [active] 324057016135 metal binding site [ion binding]; metal-binding site 324057016136 dimer interface [polypeptide binding]; other site 324057016137 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057016138 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057016139 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057016140 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 324057016141 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 324057016142 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057016143 putative ligand binding site [chemical binding]; other site 324057016144 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057016145 TM-ABC transporter signature motif; other site 324057016146 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057016147 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 324057016148 Walker A/P-loop; other site 324057016149 ATP binding site [chemical binding]; other site 324057016150 Q-loop/lid; other site 324057016151 ABC transporter signature motif; other site 324057016152 Walker B; other site 324057016153 D-loop; other site 324057016154 H-loop/switch region; other site 324057016155 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 324057016156 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 324057016157 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057016158 putative ligand binding site [chemical binding]; other site 324057016159 Cache domain; Region: Cache_1; pfam02743 324057016160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057016161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016162 dimerization interface [polypeptide binding]; other site 324057016163 Histidine kinase; Region: His_kinase; pfam06580 324057016164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016165 ATP binding site [chemical binding]; other site 324057016166 Mg2+ binding site [ion binding]; other site 324057016167 G-X-G motif; other site 324057016168 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016170 active site 324057016171 phosphorylation site [posttranslational modification] 324057016172 intermolecular recognition site; other site 324057016173 dimerization interface [polypeptide binding]; other site 324057016174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016177 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 324057016178 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 324057016179 Membrane transport protein; Region: Mem_trans; cl09117 324057016180 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 324057016181 glycerol kinase; Provisional; Region: glpK; PRK00047 324057016182 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 324057016183 N- and C-terminal domain interface [polypeptide binding]; other site 324057016184 active site 324057016185 MgATP binding site [chemical binding]; other site 324057016186 catalytic site [active] 324057016187 metal binding site [ion binding]; metal-binding site 324057016188 glycerol binding site [chemical binding]; other site 324057016189 homotetramer interface [polypeptide binding]; other site 324057016190 homodimer interface [polypeptide binding]; other site 324057016191 FBP binding site [chemical binding]; other site 324057016192 protein IIAGlc interface [polypeptide binding]; other site 324057016193 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 324057016194 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 324057016195 Glutamate binding site [chemical binding]; other site 324057016196 homodimer interface [polypeptide binding]; other site 324057016197 NAD binding site [chemical binding]; other site 324057016198 catalytic residues [active] 324057016199 Proline dehydrogenase; Region: Pro_dh; cl03282 324057016200 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324057016201 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324057016202 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324057016203 active site 324057016204 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 324057016205 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057016206 DinB superfamily; Region: DinB_2; pfam12867 324057016207 PspA/IM30 family; Region: PspA_IM30; pfam04012 324057016208 Predicted membrane protein [Function unknown]; Region: COG3766 324057016209 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 324057016210 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 324057016211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016215 dimer interface [polypeptide binding]; other site 324057016216 conserved gate region; other site 324057016217 ABC-ATPase subunit interface; other site 324057016218 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016220 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 324057016221 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 324057016222 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057016223 NAD binding site [chemical binding]; other site 324057016224 dimer interface [polypeptide binding]; other site 324057016225 substrate binding site [chemical binding]; other site 324057016226 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057016227 catalytic residues [active] 324057016228 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 324057016229 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 324057016230 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 324057016231 active site 324057016232 HIGH motif; other site 324057016233 KMSK motif region; other site 324057016234 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324057016235 tRNA binding surface [nucleotide binding]; other site 324057016236 anticodon binding site; other site 324057016237 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057016238 nudix motif; other site 324057016239 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 324057016240 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057016241 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 324057016242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057016243 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057016244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016245 NAD(P) binding site [chemical binding]; other site 324057016246 active site 324057016247 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 324057016248 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 324057016249 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324057016250 minor groove reading motif; other site 324057016251 helix-hairpin-helix signature motif; other site 324057016252 substrate binding pocket [chemical binding]; other site 324057016253 active site 324057016254 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 324057016255 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 324057016256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016258 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324057016259 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 324057016260 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324057016261 DNA binding site [nucleotide binding] 324057016262 active site 324057016263 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 324057016264 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 324057016265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057016266 catalytic residue [active] 324057016267 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 324057016268 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 324057016269 active site 324057016270 homodimer interface [polypeptide binding]; other site 324057016271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057016272 dimerization interface [polypeptide binding]; other site 324057016273 putative DNA binding site [nucleotide binding]; other site 324057016274 putative Zn2+ binding site [ion binding]; other site 324057016275 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057016276 putative hydrophobic ligand binding site [chemical binding]; other site 324057016277 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 324057016278 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 324057016279 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324057016280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057016281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057016282 DNA binding residues [nucleotide binding] 324057016283 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 324057016284 Protein of unknown function DUF72; Region: DUF72; cl00777 324057016285 hypothetical protein; Validated; Region: PRK07682 324057016286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057016287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057016288 homodimer interface [polypeptide binding]; other site 324057016289 catalytic residue [active] 324057016290 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 324057016291 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324057016292 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057016293 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057016294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057016295 DNA-binding site [nucleotide binding]; DNA binding site 324057016296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057016297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057016298 homodimer interface [polypeptide binding]; other site 324057016299 catalytic residue [active] 324057016300 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057016301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016302 NAD(P) binding site [chemical binding]; other site 324057016303 active site 324057016304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057016305 Helix-turn-helix domains; Region: HTH; cl00088 324057016306 S-layer homology domain; Region: SLH; pfam00395 324057016307 S-layer homology domain; Region: SLH; pfam00395 324057016308 S-layer homology domain; Region: SLH; pfam00395 324057016309 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057016310 active site 324057016311 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 324057016312 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057016313 NodB motif; other site 324057016314 active site 324057016315 catalytic site [active] 324057016316 metal binding site [ion binding]; metal-binding site 324057016317 MEKHLA domain; Region: MEKHLA; pfam08670 324057016318 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057016319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057016320 motif II; other site 324057016321 Domain of unknown function (DUF336); Region: DUF336; cl01249 324057016322 Helix-turn-helix domains; Region: HTH; cl00088 324057016323 short chain dehydrogenase; Provisional; Region: PRK07041 324057016324 classical (c) SDRs; Region: SDR_c; cd05233 324057016325 NAD(P) binding site [chemical binding]; other site 324057016326 active site 324057016327 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 324057016328 substrate binding pocket [chemical binding]; other site 324057016329 substrate-Mg2+ binding site; other site 324057016330 aspartate-rich region 1; other site 324057016331 aspartate-rich region 2; other site 324057016332 Predicted transcriptional regulator [Transcription]; Region: COG2345 324057016333 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057016334 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057016335 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057016336 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057016337 putative active site [active] 324057016338 putative metal binding site [ion binding]; other site 324057016339 NlpC/P60 family; Region: NLPC_P60; cl11438 324057016340 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057016341 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324057016342 substrate binding pocket [chemical binding]; other site 324057016343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 324057016344 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 324057016345 dimer interface [polypeptide binding]; other site 324057016346 substrate binding site [chemical binding]; other site 324057016347 ATP binding site [chemical binding]; other site 324057016348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016349 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 324057016350 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 324057016351 ThiS interaction site; other site 324057016352 putative active site [active] 324057016353 tetramer interface [polypeptide binding]; other site 324057016354 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 324057016355 thiS-thiF/thiG interaction site; other site 324057016356 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 324057016357 thiamine phosphate binding site [chemical binding]; other site 324057016358 active site 324057016359 pyrophosphate binding site [ion binding]; other site 324057016360 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 324057016361 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 324057016362 ATP binding site [chemical binding]; other site 324057016363 substrate interface [chemical binding]; other site 324057016364 NMT1/THI5 like; Region: NMT1; pfam09084 324057016365 NMT1-like family; Region: NMT1_2; cl15260 324057016366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016367 dimer interface [polypeptide binding]; other site 324057016368 conserved gate region; other site 324057016369 ABC-ATPase subunit interface; other site 324057016370 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057016371 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057016372 Walker A/P-loop; other site 324057016373 ATP binding site [chemical binding]; other site 324057016374 Q-loop/lid; other site 324057016375 ABC transporter signature motif; other site 324057016376 Walker B; other site 324057016377 D-loop; other site 324057016378 H-loop/switch region; other site 324057016379 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 324057016380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057016381 Helix-turn-helix domains; Region: HTH; cl00088 324057016382 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057016383 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057016384 Walker A/P-loop; other site 324057016385 ATP binding site [chemical binding]; other site 324057016386 Q-loop/lid; other site 324057016387 ABC transporter signature motif; other site 324057016388 Walker B; other site 324057016389 D-loop; other site 324057016390 H-loop/switch region; other site 324057016391 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057016392 active site 324057016393 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 324057016394 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016396 dimer interface [polypeptide binding]; other site 324057016397 conserved gate region; other site 324057016398 putative PBP binding loops; other site 324057016399 ABC-ATPase subunit interface; other site 324057016400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016401 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057016402 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016406 DNA binding site [nucleotide binding] 324057016407 domain linker motif; other site 324057016408 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 324057016409 putative dimerization interface [polypeptide binding]; other site 324057016410 putative ligand binding site [chemical binding]; other site 324057016411 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 324057016412 putative active site; other site 324057016413 putative metal binding residues [ion binding]; other site 324057016414 signature motif; other site 324057016415 putative triphosphate binding site [ion binding]; other site 324057016416 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 324057016417 Protein of unknown function (DUF779); Region: DUF779; cl01432 324057016418 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 324057016419 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324057016420 NAD(P) binding site [chemical binding]; other site 324057016421 catalytic residues [active] 324057016422 heat shock protein 90; Provisional; Region: PRK05218 324057016423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057016424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057016425 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057016426 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 324057016427 tetramer interface [polypeptide binding]; other site 324057016428 heme binding pocket [chemical binding]; other site 324057016429 NADPH binding site [chemical binding]; other site 324057016430 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324057016431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016432 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 324057016433 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 324057016434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057016435 Zn binding site [ion binding]; other site 324057016436 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 324057016437 Zn binding site [ion binding]; other site 324057016438 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 324057016439 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324057016440 dimerization interface [polypeptide binding]; other site 324057016441 DPS ferroxidase diiron center [ion binding]; other site 324057016442 ion pore; other site 324057016443 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 324057016444 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057016445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016446 putative substrate translocation pore; other site 324057016447 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 324057016448 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 324057016449 active site 324057016450 Isochorismatase family; Region: Isochorismatase; pfam00857 324057016451 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 324057016452 catalytic triad [active] 324057016453 dimer interface [polypeptide binding]; other site 324057016454 conserved cis-peptide bond; other site 324057016455 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 324057016456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057016457 nucleophilic elbow; other site 324057016458 catalytic triad; other site 324057016459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057016460 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016462 active site 324057016463 phosphorylation site [posttranslational modification] 324057016464 intermolecular recognition site; other site 324057016465 dimerization interface [polypeptide binding]; other site 324057016466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057016468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016469 dimerization interface [polypeptide binding]; other site 324057016470 Histidine kinase; Region: His_kinase; pfam06580 324057016471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016472 ATP binding site [chemical binding]; other site 324057016473 Mg2+ binding site [ion binding]; other site 324057016474 G-X-G motif; other site 324057016475 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057016477 Helix-turn-helix domains; Region: HTH; cl00088 324057016478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057016479 dimerization interface [polypeptide binding]; other site 324057016480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057016481 Helix-turn-helix domains; Region: HTH; cl00088 324057016482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057016483 dimerization interface [polypeptide binding]; other site 324057016484 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057016485 MatE; Region: MatE; cl10513 324057016486 MatE; Region: MatE; cl10513 324057016487 Cupin domain; Region: Cupin_2; cl09118 324057016488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016489 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016491 Cupin domain; Region: Cupin_2; cl09118 324057016492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324057016493 active site 324057016494 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 324057016495 putative ADP-binding pocket [chemical binding]; other site 324057016496 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 324057016497 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 324057016498 substrate binding site; other site 324057016499 metal-binding site 324057016500 Oligomer interface; other site 324057016501 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324057016502 putative trimer interface [polypeptide binding]; other site 324057016503 putative CoA binding site [chemical binding]; other site 324057016504 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057016505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057016506 S-adenosylmethionine binding site [chemical binding]; other site 324057016507 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057016508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016509 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 324057016510 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057016511 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057016512 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057016513 Cupin domain; Region: Cupin_2; cl09118 324057016514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057016518 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057016519 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 324057016520 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 324057016521 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 324057016522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016523 DNA binding site [nucleotide binding] 324057016524 domain linker motif; other site 324057016525 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 324057016526 putative dimerization interface [polypeptide binding]; other site 324057016527 putative ligand binding site [chemical binding]; other site 324057016528 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057016529 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057016530 Walker A/P-loop; other site 324057016531 ATP binding site [chemical binding]; other site 324057016532 Q-loop/lid; other site 324057016533 ABC transporter signature motif; other site 324057016534 Walker B; other site 324057016535 D-loop; other site 324057016536 H-loop/switch region; other site 324057016537 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 324057016538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324057016539 FtsX-like permease family; Region: FtsX; cl15850 324057016540 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 324057016541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016542 dimerization interface [polypeptide binding]; other site 324057016543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057016544 dimer interface [polypeptide binding]; other site 324057016545 phosphorylation site [posttranslational modification] 324057016546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016547 ATP binding site [chemical binding]; other site 324057016548 Mg2+ binding site [ion binding]; other site 324057016549 G-X-G motif; other site 324057016550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057016551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016552 active site 324057016553 phosphorylation site [posttranslational modification] 324057016554 intermolecular recognition site; other site 324057016555 dimerization interface [polypeptide binding]; other site 324057016556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057016557 DNA binding site [nucleotide binding] 324057016558 Ferredoxin [Energy production and conversion]; Region: COG1146 324057016559 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 324057016560 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 324057016561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324057016562 NMT1/THI5 like; Region: NMT1; pfam09084 324057016563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057016564 substrate binding pocket [chemical binding]; other site 324057016565 membrane-bound complex binding site; other site 324057016566 Ferredoxin [Energy production and conversion]; Region: COG1146 324057016567 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 324057016568 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 324057016569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016570 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324057016571 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057016572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016573 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057016574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016576 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057016577 putative substrate translocation pore; other site 324057016578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057016580 Helix-turn-helix domains; Region: HTH; cl00088 324057016581 Predicted integral membrane protein [Function unknown]; Region: COG5658 324057016582 SdpI/YhfL protein family; Region: SdpI; pfam13630 324057016583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057016584 dimerization interface [polypeptide binding]; other site 324057016585 putative DNA binding site [nucleotide binding]; other site 324057016586 putative Zn2+ binding site [ion binding]; other site 324057016587 tetracycline repressor protein TetR; Provisional; Region: PRK13756 324057016588 Helix-turn-helix domains; Region: HTH; cl00088 324057016589 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 324057016590 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057016591 MatE; Region: MatE; cl10513 324057016592 MatE; Region: MatE; cl10513 324057016593 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057016594 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057016595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057016596 Walker A/P-loop; other site 324057016597 ATP binding site [chemical binding]; other site 324057016598 Q-loop/lid; other site 324057016599 ABC transporter signature motif; other site 324057016600 Walker B; other site 324057016601 D-loop; other site 324057016602 H-loop/switch region; other site 324057016603 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057016604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057016605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057016606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057016607 Helix-turn-helix domains; Region: HTH; cl00088 324057016608 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 324057016609 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 324057016610 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057016611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057016612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057016613 active site 324057016614 metal binding site [ion binding]; metal-binding site 324057016615 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016616 DinB superfamily; Region: DinB_2; pfam12867 324057016617 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 324057016618 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 324057016619 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 324057016620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057016621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016622 active site 324057016623 phosphorylation site [posttranslational modification] 324057016624 intermolecular recognition site; other site 324057016625 dimerization interface [polypeptide binding]; other site 324057016626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057016627 DNA binding residues [nucleotide binding] 324057016628 dimerization interface [polypeptide binding]; other site 324057016629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057016630 Histidine kinase; Region: HisKA_3; pfam07730 324057016631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057016632 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057016633 sugar binding site [chemical binding]; other site 324057016634 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057016635 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 324057016636 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057016637 sugar binding site [chemical binding]; other site 324057016638 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057016639 sugar binding site [chemical binding]; other site 324057016640 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 324057016641 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 324057016642 Ligand binding site; other site 324057016643 Putative Catalytic site; other site 324057016644 DXD motif; other site 324057016645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016646 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 324057016647 NAD(P) binding site [chemical binding]; other site 324057016648 active site 324057016649 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057016650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016651 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057016652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016653 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057016654 Helix-turn-helix domains; Region: HTH; cl00088 324057016655 Helix-turn-helix domains; Region: HTH; cl00088 324057016656 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 324057016657 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057016658 catalytic core [active] 324057016659 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324057016660 ligand binding site [chemical binding]; other site 324057016661 flexible hinge region; other site 324057016662 Helix-turn-helix domains; Region: HTH; cl00088 324057016663 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 324057016664 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 324057016665 heme-binding site [chemical binding]; other site 324057016666 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 324057016667 FAD binding pocket [chemical binding]; other site 324057016668 FAD binding motif [chemical binding]; other site 324057016669 phosphate binding motif [ion binding]; other site 324057016670 beta-alpha-beta structure motif; other site 324057016671 NAD binding pocket [chemical binding]; other site 324057016672 Heme binding pocket [chemical binding]; other site 324057016673 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057016674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057016675 Walker A motif; other site 324057016676 ATP binding site [chemical binding]; other site 324057016677 Walker B motif; other site 324057016678 arginine finger; other site 324057016679 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 324057016680 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057016681 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057016682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057016683 Coenzyme A binding pocket [chemical binding]; other site 324057016684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 324057016685 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057016686 Uncharacterized conserved protein [Function unknown]; Region: COG0327 324057016687 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 324057016688 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324057016689 Ligand Binding Site [chemical binding]; other site 324057016690 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057016691 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016693 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057016694 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016696 dimer interface [polypeptide binding]; other site 324057016697 ABC-ATPase subunit interface; other site 324057016698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016699 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016700 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057016701 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057016702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016704 DNA binding site [nucleotide binding] 324057016705 domain linker motif; other site 324057016706 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057016707 dimerization interface [polypeptide binding]; other site 324057016708 ligand binding site [chemical binding]; other site 324057016709 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 324057016710 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 324057016711 homodimer interface [polypeptide binding]; other site 324057016712 NAD binding pocket [chemical binding]; other site 324057016713 ATP binding pocket [chemical binding]; other site 324057016714 Mg binding site [ion binding]; other site 324057016715 active-site loop [active] 324057016716 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 324057016717 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 324057016718 active site 324057016719 (T/H)XGH motif; other site 324057016720 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 324057016721 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 324057016722 active site 324057016723 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 324057016724 catalytic triad [active] 324057016725 conserved cis-peptide bond; other site 324057016726 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057016727 nudix motif; other site 324057016728 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057016729 Spore germination protein; Region: Spore_permease; cl15802 324057016730 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057016731 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057016732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057016733 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 324057016734 YCII-related domain; Region: YCII; cl00999 324057016735 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 324057016736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057016737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057016738 YCII-related domain; Region: YCII; cl00999 324057016739 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057016740 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 324057016741 putative deacylase active site [active] 324057016742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016744 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016746 active site 324057016747 phosphorylation site [posttranslational modification] 324057016748 intermolecular recognition site; other site 324057016749 dimerization interface [polypeptide binding]; other site 324057016750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057016753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057016754 Histidine kinase; Region: His_kinase; pfam06580 324057016755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016756 ATP binding site [chemical binding]; other site 324057016757 Mg2+ binding site [ion binding]; other site 324057016758 G-X-G motif; other site 324057016759 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016761 dimer interface [polypeptide binding]; other site 324057016762 conserved gate region; other site 324057016763 putative PBP binding loops; other site 324057016764 ABC-ATPase subunit interface; other site 324057016765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016766 dimer interface [polypeptide binding]; other site 324057016767 conserved gate region; other site 324057016768 putative PBP binding loops; other site 324057016769 ABC-ATPase subunit interface; other site 324057016770 Right handed beta helix region; Region: Beta_helix; pfam13229 324057016771 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057016772 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 324057016773 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057016774 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057016775 S-layer homology domain; Region: SLH; pfam00395 324057016776 S-layer homology domain; Region: SLH; pfam00395 324057016777 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057016778 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057016779 putative metal binding site [ion binding]; other site 324057016780 potential frameshift: common BLAST hit: gi|150392276|ref|YP_001322325.1| membrane protein 324057016781 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 324057016782 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 324057016783 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 324057016784 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324057016785 active site 324057016786 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057016787 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016788 Interdomain contacts; other site 324057016789 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057016790 Cytokine receptor motif; other site 324057016791 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 324057016792 active site 324057016793 catalytic triad [active] 324057016794 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016795 Interdomain contacts; other site 324057016796 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057016797 Cytokine receptor motif; other site 324057016798 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016799 Interdomain contacts; other site 324057016800 Cytokine receptor motif; other site 324057016801 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057016802 metal binding site [ion binding]; metal-binding site 324057016803 active site 324057016804 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057016805 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057016806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057016807 dimerization interface [polypeptide binding]; other site 324057016808 putative DNA binding site [nucleotide binding]; other site 324057016809 putative Zn2+ binding site [ion binding]; other site 324057016810 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057016811 hydrophobic ligand binding site; other site 324057016812 OsmC-like protein; Region: OsmC; cl00767 324057016813 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 324057016814 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057016815 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 324057016816 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057016817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057016818 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 324057016819 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 324057016820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324057016821 NAD(P) binding site [chemical binding]; other site 324057016822 catalytic residues [active] 324057016823 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057016824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016825 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 324057016826 putative hydrophobic ligand binding site [chemical binding]; other site 324057016827 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 324057016828 putative ligand binding site [chemical binding]; other site 324057016829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057016832 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057016833 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057016834 DNA interaction; other site 324057016835 Metal-binding active site; metal-binding site 324057016836 Cupin domain; Region: Cupin_2; cl09118 324057016837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016841 DNA binding site [nucleotide binding] 324057016842 domain linker motif; other site 324057016843 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057016844 ligand binding site [chemical binding]; other site 324057016845 dimerization interface [polypeptide binding]; other site 324057016846 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016848 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016850 dimer interface [polypeptide binding]; other site 324057016851 conserved gate region; other site 324057016852 putative PBP binding loops; other site 324057016853 ABC-ATPase subunit interface; other site 324057016854 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016856 dimer interface [polypeptide binding]; other site 324057016857 putative PBP binding loops; other site 324057016858 ABC-ATPase subunit interface; other site 324057016859 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016861 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057016862 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057016863 S-layer homology domain; Region: SLH; pfam00395 324057016864 S-layer homology domain; Region: SLH; pfam00395 324057016865 S-layer homology domain; Region: SLH; pfam00395 324057016866 TM1410 hypothetical-related protein; Region: DUF297; cl00997 324057016867 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016868 Interdomain contacts; other site 324057016869 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016870 Interdomain contacts; other site 324057016871 Cytokine receptor motif; other site 324057016872 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 324057016873 AMP-binding enzyme; Region: AMP-binding; cl15778 324057016874 Phosphopantetheine attachment site; Region: PP-binding; cl09936 324057016875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016876 thioester reductase domain; Region: Thioester-redct; TIGR01746 324057016877 NAD(P) binding site [chemical binding]; other site 324057016878 active site 324057016879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057016880 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057016881 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057016882 dimer interface [polypeptide binding]; other site 324057016883 putative CheW interface [polypeptide binding]; other site 324057016884 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057016885 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 324057016886 active site 324057016887 metal binding site [ion binding]; metal-binding site 324057016888 homodimer interface [polypeptide binding]; other site 324057016889 catalytic site [active] 324057016890 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057016891 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057016892 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 324057016893 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 324057016894 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016896 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016898 dimer interface [polypeptide binding]; other site 324057016899 conserved gate region; other site 324057016900 ABC-ATPase subunit interface; other site 324057016901 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016903 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057016904 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016906 active site 324057016907 phosphorylation site [posttranslational modification] 324057016908 intermolecular recognition site; other site 324057016909 dimerization interface [polypeptide binding]; other site 324057016910 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016913 dimerization interface [polypeptide binding]; other site 324057016914 Histidine kinase; Region: His_kinase; pfam06580 324057016915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016916 ATP binding site [chemical binding]; other site 324057016917 Mg2+ binding site [ion binding]; other site 324057016918 G-X-G motif; other site 324057016919 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057016920 Putative esterase; Region: Esterase; pfam00756 324057016921 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 324057016922 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016924 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057016925 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 324057016926 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016928 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016930 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016932 dimer interface [polypeptide binding]; other site 324057016933 conserved gate region; other site 324057016934 ABC-ATPase subunit interface; other site 324057016935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057016936 Histidine kinase; Region: His_kinase; pfam06580 324057016937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016938 ATP binding site [chemical binding]; other site 324057016939 Mg2+ binding site [ion binding]; other site 324057016940 G-X-G motif; other site 324057016941 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016943 active site 324057016944 phosphorylation site [posttranslational modification] 324057016945 intermolecular recognition site; other site 324057016946 dimerization interface [polypeptide binding]; other site 324057016947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057016951 Helix-turn-helix domains; Region: HTH; cl00088 324057016952 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016954 dimer interface [polypeptide binding]; other site 324057016955 conserved gate region; other site 324057016956 putative PBP binding loops; other site 324057016957 ABC-ATPase subunit interface; other site 324057016958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016959 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016961 LrgB-like family; Region: LrgB; cl00596 324057016962 LrgA family; Region: LrgA; cl00608 324057016963 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 324057016964 Helix-turn-helix domains; Region: HTH; cl00088 324057016965 short chain dehydrogenase; Provisional; Region: PRK06523 324057016966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016967 NAD(P) binding site [chemical binding]; other site 324057016968 active site 324057016969 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 324057016970 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016972 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057016973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057016974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016975 dimerization interface [polypeptide binding]; other site 324057016976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057016977 dimer interface [polypeptide binding]; other site 324057016978 phosphorylation site [posttranslational modification] 324057016979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016980 ATP binding site [chemical binding]; other site 324057016981 Mg2+ binding site [ion binding]; other site 324057016982 G-X-G motif; other site 324057016983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057016984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016985 active site 324057016986 phosphorylation site [posttranslational modification] 324057016987 intermolecular recognition site; other site 324057016988 dimerization interface [polypeptide binding]; other site 324057016989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057016990 DNA binding site [nucleotide binding] 324057016991 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 324057016992 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324057016993 ATP-grasp domain; Region: ATP-grasp_4; cl03087 324057016994 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 324057016995 alanine racemase; Reviewed; Region: alr; PRK00053 324057016996 active site 324057016997 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057016998 dimer interface [polypeptide binding]; other site 324057016999 substrate binding site [chemical binding]; other site 324057017000 catalytic residues [active] 324057017001 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 324057017002 OpgC protein; Region: OpgC_C; cl00792 324057017003 Cupin domain; Region: Cupin_2; cl09118 324057017004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017005 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017007 Sulfatase; Region: Sulfatase; cl10460 324057017008 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057017009 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 324057017010 beta-D-glucuronidase; Provisional; Region: PRK10150 324057017011 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057017012 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057017013 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 324057017014 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057017015 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017017 dimer interface [polypeptide binding]; other site 324057017018 conserved gate region; other site 324057017019 putative PBP binding loops; other site 324057017020 ABC-ATPase subunit interface; other site 324057017021 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017023 dimer interface [polypeptide binding]; other site 324057017024 conserved gate region; other site 324057017025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057017026 ABC-ATPase subunit interface; other site 324057017027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057017028 Response regulator receiver domain; Region: Response_reg; pfam00072 324057017029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017030 active site 324057017031 phosphorylation site [posttranslational modification] 324057017032 intermolecular recognition site; other site 324057017033 dimerization interface [polypeptide binding]; other site 324057017034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057017037 Histidine kinase; Region: His_kinase; pfam06580 324057017038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017039 ATP binding site [chemical binding]; other site 324057017040 Mg2+ binding site [ion binding]; other site 324057017041 G-X-G motif; other site 324057017042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017043 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017045 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057017046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017047 active site 324057017048 metal binding site [ion binding]; metal-binding site 324057017049 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 324057017050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017051 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 324057017052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017055 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017056 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017057 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057017058 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057017059 DNA binding residues [nucleotide binding] 324057017060 putative dimer interface [polypeptide binding]; other site 324057017061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017062 NAD(P) binding site [chemical binding]; other site 324057017063 active site 324057017064 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 324057017065 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 324057017066 glutaminase active site [active] 324057017067 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 324057017068 dimer interface [polypeptide binding]; other site 324057017069 active site 324057017070 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 324057017071 dimer interface [polypeptide binding]; other site 324057017072 active site 324057017073 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 324057017074 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 324057017075 active site 324057017076 substrate binding site [chemical binding]; other site 324057017077 metal binding site [ion binding]; metal-binding site 324057017078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 324057017079 YbbR-like protein; Region: YbbR; pfam07949 324057017080 TIGR00159 family protein; Region: TIGR00159 324057017081 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 324057017082 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 324057017083 Putative zinc-finger; Region: zf-HC2; cl15806 324057017084 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 324057017085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057017086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057017087 DNA binding residues [nucleotide binding] 324057017088 EamA-like transporter family; Region: EamA; cl01037 324057017089 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 324057017090 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 324057017091 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 324057017092 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057017093 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057017094 Walker A/P-loop; other site 324057017095 ATP binding site [chemical binding]; other site 324057017096 Q-loop/lid; other site 324057017097 ABC transporter signature motif; other site 324057017098 Walker B; other site 324057017099 D-loop; other site 324057017100 H-loop/switch region; other site 324057017101 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 324057017102 dimer interface [polypeptide binding]; other site 324057017103 FMN binding site [chemical binding]; other site 324057017104 NADPH bind site [chemical binding]; other site 324057017105 Integral membrane protein DUF95; Region: DUF95; cl00572 324057017106 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057017107 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057017108 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 324057017109 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 324057017110 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057017111 active site 324057017112 metal binding site [ion binding]; metal-binding site 324057017113 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 324057017114 Active Sites [active] 324057017115 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 324057017116 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 324057017117 23S rRNA interface [nucleotide binding]; other site 324057017118 L3 interface [polypeptide binding]; other site 324057017119 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 324057017120 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 324057017121 dimerization interface 3.5A [polypeptide binding]; other site 324057017122 active site 324057017123 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 324057017124 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 324057017125 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 324057017126 alphaNTD - beta interaction site [polypeptide binding]; other site 324057017127 alphaNTD homodimer interface [polypeptide binding]; other site 324057017128 alphaNTD - beta' interaction site [polypeptide binding]; other site 324057017129 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 324057017130 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 324057017131 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 324057017132 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 324057017133 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 324057017134 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 324057017135 rRNA binding site [nucleotide binding]; other site 324057017136 predicted 30S ribosome binding site; other site 324057017137 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 324057017138 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324057017139 active site 324057017140 adenylate kinase; Reviewed; Region: adk; PRK00279 324057017141 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 324057017142 AMP-binding site [chemical binding]; other site 324057017143 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 324057017144 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 324057017145 SecY translocase; Region: SecY; pfam00344 324057017146 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 324057017147 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 324057017148 23S rRNA binding site [nucleotide binding]; other site 324057017149 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 324057017150 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 324057017151 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 324057017152 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 324057017153 5S rRNA interface [nucleotide binding]; other site 324057017154 L27 interface [polypeptide binding]; other site 324057017155 23S rRNA interface [nucleotide binding]; other site 324057017156 L5 interface [polypeptide binding]; other site 324057017157 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 324057017158 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324057017159 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324057017160 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 324057017161 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 324057017162 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 324057017163 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 324057017164 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 324057017165 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 324057017166 KOW motif; Region: KOW; cl00354 324057017167 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 324057017168 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 324057017169 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 324057017170 23S rRNA interface [nucleotide binding]; other site 324057017171 putative translocon interaction site; other site 324057017172 signal recognition particle (SRP54) interaction site; other site 324057017173 L23 interface [polypeptide binding]; other site 324057017174 trigger factor interaction site; other site 324057017175 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 324057017176 23S rRNA interface [nucleotide binding]; other site 324057017177 5S rRNA interface [nucleotide binding]; other site 324057017178 putative antibiotic binding site [chemical binding]; other site 324057017179 L25 interface [polypeptide binding]; other site 324057017180 L27 interface [polypeptide binding]; other site 324057017181 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 324057017182 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 324057017183 G-X-X-G motif; other site 324057017184 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 324057017185 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 324057017186 putative translocon binding site; other site 324057017187 protein-rRNA interface [nucleotide binding]; other site 324057017188 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 324057017189 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 324057017190 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 324057017191 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 324057017192 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 324057017193 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 324057017194 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 324057017195 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 324057017196 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 324057017197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057017198 Walker A/P-loop; other site 324057017199 ATP binding site [chemical binding]; other site 324057017200 Q-loop/lid; other site 324057017201 ABC transporter signature motif; other site 324057017202 Walker B; other site 324057017203 D-loop; other site 324057017204 H-loop/switch region; other site 324057017205 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 324057017206 TM-ABC transporter signature motif; other site 324057017207 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 324057017208 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057017209 zinc binding site [ion binding]; other site 324057017210 putative ligand binding site [chemical binding]; other site 324057017211 elongation factor Tu; Reviewed; Region: PRK00049 324057017212 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 324057017213 G1 box; other site 324057017214 GEF interaction site [polypeptide binding]; other site 324057017215 GTP/Mg2+ binding site [chemical binding]; other site 324057017216 Switch I region; other site 324057017217 G2 box; other site 324057017218 G3 box; other site 324057017219 Switch II region; other site 324057017220 G4 box; other site 324057017221 G5 box; other site 324057017222 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 324057017223 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 324057017224 Antibiotic Binding Site [chemical binding]; other site 324057017225 elongation factor G; Reviewed; Region: PRK00007 324057017226 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 324057017227 G1 box; other site 324057017228 putative GEF interaction site [polypeptide binding]; other site 324057017229 GTP/Mg2+ binding site [chemical binding]; other site 324057017230 Switch I region; other site 324057017231 G2 box; other site 324057017232 G3 box; other site 324057017233 Switch II region; other site 324057017234 G4 box; other site 324057017235 G5 box; other site 324057017236 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324057017237 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 324057017238 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 324057017239 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 324057017240 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 324057017241 S17 interaction site [polypeptide binding]; other site 324057017242 S8 interaction site; other site 324057017243 16S rRNA interaction site [nucleotide binding]; other site 324057017244 streptomycin interaction site [chemical binding]; other site 324057017245 23S rRNA interaction site [nucleotide binding]; other site 324057017246 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 324057017247 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 324057017248 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 324057017249 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 324057017250 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 324057017251 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 324057017252 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 324057017253 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 324057017254 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 324057017255 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 324057017256 G-loop; other site 324057017257 DNA binding site [nucleotide binding] 324057017258 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 324057017259 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 324057017260 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 324057017261 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 324057017262 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 324057017263 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 324057017264 RPB12 interaction site [polypeptide binding]; other site 324057017265 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 324057017266 RPB10 interaction site [polypeptide binding]; other site 324057017267 RPB1 interaction site [polypeptide binding]; other site 324057017268 RPB11 interaction site [polypeptide binding]; other site 324057017269 RPB3 interaction site [polypeptide binding]; other site 324057017270 RPB12 interaction site [polypeptide binding]; other site 324057017271 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057017272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057017273 S-adenosylmethionine binding site [chemical binding]; other site 324057017274 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 324057017275 core dimer interface [polypeptide binding]; other site 324057017276 peripheral dimer interface [polypeptide binding]; other site 324057017277 L10 interface [polypeptide binding]; other site 324057017278 L11 interface [polypeptide binding]; other site 324057017279 putative EF-Tu interaction site [polypeptide binding]; other site 324057017280 putative EF-G interaction site [polypeptide binding]; other site 324057017281 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 324057017282 23S rRNA interface [nucleotide binding]; other site 324057017283 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 324057017284 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 324057017285 mRNA/rRNA interface [nucleotide binding]; other site 324057017286 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 324057017287 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 324057017288 23S rRNA interface [nucleotide binding]; other site 324057017289 L7/L12 interface [polypeptide binding]; other site 324057017290 putative thiostrepton binding site; other site 324057017291 L25 interface [polypeptide binding]; other site 324057017292 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 324057017293 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 324057017294 putative homodimer interface [polypeptide binding]; other site 324057017295 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 324057017296 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 324057017297 RNA polymerase factor sigma-70; Validated; Region: PRK08295 324057017298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057017299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057017300 YacP-like NYN domain; Region: NYN_YacP; cl01491 324057017301 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 324057017302 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 324057017303 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 324057017304 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 324057017305 active site 324057017306 metal binding site [ion binding]; metal-binding site 324057017307 dimerization interface [polypeptide binding]; other site 324057017308 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 324057017309 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324057017310 active site 324057017311 HIGH motif; other site 324057017312 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324057017313 KMSKS motif; other site 324057017314 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324057017315 anticodon binding site; other site 324057017316 tRNA binding surface [nucleotide binding]; other site 324057017317 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324057017318 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 324057017319 serine O-acetyltransferase; Region: cysE; TIGR01172 324057017320 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 324057017321 trimer interface [polypeptide binding]; other site 324057017322 active site 324057017323 substrate binding site [chemical binding]; other site 324057017324 CoA binding site [chemical binding]; other site 324057017325 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 324057017326 homotrimer interaction site [polypeptide binding]; other site 324057017327 zinc binding site [ion binding]; other site 324057017328 CDP-binding sites; other site 324057017329 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 324057017330 substrate binding site; other site 324057017331 dimer interface; other site 324057017332 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 324057017333 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 324057017334 putative active site [active] 324057017335 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 324057017336 metal binding site [ion binding]; metal-binding site 324057017337 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 324057017338 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057017339 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 324057017340 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 324057017341 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 324057017342 DNA repair protein RadA; Provisional; Region: PRK11823 324057017343 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 324057017344 Walker A motif/ATP binding site; other site 324057017345 ATP binding site [chemical binding]; other site 324057017346 Walker B motif; other site 324057017347 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 324057017348 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057017349 Clp protease ATP binding subunit; Region: clpC; CHL00095 324057017350 Clp amino terminal domain; Region: Clp_N; pfam02861 324057017351 Clp amino terminal domain; Region: Clp_N; pfam02861 324057017352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057017353 Walker A motif; other site 324057017354 ATP binding site [chemical binding]; other site 324057017355 Walker B motif; other site 324057017356 arginine finger; other site 324057017357 UvrB/uvrC motif; Region: UVR; pfam02151 324057017358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057017359 Walker A motif; other site 324057017360 ATP binding site [chemical binding]; other site 324057017361 Walker B motif; other site 324057017362 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 324057017363 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 324057017364 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 324057017365 ADP binding site [chemical binding]; other site 324057017366 phosphagen binding site; other site 324057017367 substrate specificity loop; other site 324057017368 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 324057017369 UvrB/uvrC motif; Region: UVR; pfam02151 324057017370 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 324057017371 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 324057017372 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 324057017373 nucleotide binding pocket [chemical binding]; other site 324057017374 K-X-D-G motif; other site 324057017375 catalytic site [active] 324057017376 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 324057017377 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 324057017378 Dimer interface [polypeptide binding]; other site 324057017379 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 324057017380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057017381 Family description; Region: UvrD_C_2; cl15862 324057017382 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 324057017383 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 324057017384 substrate binding site [chemical binding]; other site 324057017385 putative active site [active] 324057017386 dimer interface [polypeptide binding]; other site 324057017387 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 324057017388 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057017389 Peptidase family U32; Region: Peptidase_U32; cl03113 324057017390 Collagenase; Region: DUF3656; pfam12392 324057017391 Peptidase family U32; Region: Peptidase_U32; cl03113 324057017392 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057017393 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 324057017394 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057017395 protein binding site [polypeptide binding]; other site 324057017396 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057017397 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 324057017398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057017399 putative DNA binding site [nucleotide binding]; other site 324057017400 dimerization interface [polypeptide binding]; other site 324057017401 putative Zn2+ binding site [ion binding]; other site 324057017402 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 324057017403 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 324057017404 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 324057017405 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 324057017406 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 324057017407 excinuclease ABC subunit B; Provisional; Region: PRK05298 324057017408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057017409 ATP binding site [chemical binding]; other site 324057017410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057017411 nucleotide binding region [chemical binding]; other site 324057017412 ATP-binding site [chemical binding]; other site 324057017413 Ultra-violet resistance protein B; Region: UvrB; pfam12344 324057017414 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057017415 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 324057017416 C-terminal peptidase (prc); Region: prc; TIGR00225 324057017417 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324057017418 protein binding site [polypeptide binding]; other site 324057017419 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324057017420 Catalytic dyad [active] 324057017421 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 324057017422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 324057017423 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057017424 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 324057017425 FtsX-like permease family; Region: FtsX; cl15850 324057017426 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 324057017427 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 324057017428 Walker A/P-loop; other site 324057017429 ATP binding site [chemical binding]; other site 324057017430 Q-loop/lid; other site 324057017431 ABC transporter signature motif; other site 324057017432 Walker B; other site 324057017433 D-loop; other site 324057017434 H-loop/switch region; other site 324057017435 VanW like protein; Region: VanW; pfam04294 324057017436 G5 domain; Region: G5; pfam07501 324057017437 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057017438 putative active site [active] 324057017439 argininosuccinate lyase; Provisional; Region: PRK00855 324057017440 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 324057017441 active sites [active] 324057017442 tetramer interface [polypeptide binding]; other site 324057017443 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 324057017444 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 324057017445 ANP binding site [chemical binding]; other site 324057017446 Substrate Binding Site II [chemical binding]; other site 324057017447 Substrate Binding Site I [chemical binding]; other site 324057017448 ornithine carbamoyltransferase; Provisional; Region: PRK00779 324057017449 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324057017450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017451 acetylornithine aminotransferase; Provisional; Region: PRK02627 324057017452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057017453 inhibitor-cofactor binding pocket; inhibition site 324057017454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057017455 catalytic residue [active] 324057017456 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 324057017457 nucleotide binding site [chemical binding]; other site 324057017458 N-acetyl-L-glutamate binding site [chemical binding]; other site 324057017459 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 324057017460 heterotetramer interface [polypeptide binding]; other site 324057017461 active site pocket [active] 324057017462 cleavage site 324057017463 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 324057017464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017465 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 324057017466 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057017467 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057017468 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057017469 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 324057017470 peptide chain release factor 2; Validated; Region: prfB; PRK00578 324057017471 RF-1 domain; Region: RF-1; cl02875 324057017472 RF-1 domain; Region: RF-1; cl02875 324057017473 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 324057017474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057017475 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 324057017476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057017477 nucleotide binding region [chemical binding]; other site 324057017478 ATP-binding site [chemical binding]; other site 324057017479 SEC-C motif; Region: SEC-C; pfam02810 324057017480 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 324057017481 30S subunit binding site; other site 324057017482 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 324057017483 DNA-binding site [nucleotide binding]; DNA binding site 324057017484 RNA-binding motif; other site 324057017485 Flagellar protein FliS; Region: FliS; cl00654 324057017486 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 324057017487 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 324057017488 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 324057017489 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 324057017490 FlaG protein; Region: FlaG; cl00591 324057017491 UDP-glucose 4-epimerase; Region: PLN02240 324057017492 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324057017493 NAD binding site [chemical binding]; other site 324057017494 homodimer interface [polypeptide binding]; other site 324057017495 active site 324057017496 substrate binding site [chemical binding]; other site 324057017497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057017498 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057017499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057017500 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 324057017501 trimer interface [polypeptide binding]; other site 324057017502 active site 324057017503 substrate binding site [chemical binding]; other site 324057017504 CoA binding site [chemical binding]; other site 324057017505 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057017506 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057017507 putative metal binding site; other site 324057017508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057017509 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057017510 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 324057017511 flagellin; Provisional; Region: PRK12804 324057017512 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 324057017513 Global regulator protein family; Region: CsrA; cl00670 324057017514 FliW protein; Region: FliW; cl00740 324057017515 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 324057017516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 324057017517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 324057017518 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 324057017519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 324057017520 FlgN protein; Region: FlgN; cl09176 324057017521 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 324057017522 flagellar operon protein TIGR03826; Region: YvyF 324057017523 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 324057017524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057017525 active site 324057017526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057017527 ATP binding site [chemical binding]; other site 324057017528 putative Mg++ binding site [ion binding]; other site 324057017529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057017530 nucleotide binding region [chemical binding]; other site 324057017531 ATP-binding site [chemical binding]; other site 324057017532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057017533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017534 active site 324057017535 phosphorylation site [posttranslational modification] 324057017536 intermolecular recognition site; other site 324057017537 dimerization interface [polypeptide binding]; other site 324057017538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057017539 DNA binding residues [nucleotide binding] 324057017540 dimerization interface [polypeptide binding]; other site 324057017541 Sensor protein DegS; Region: DegS; pfam05384 324057017542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057017543 Histidine kinase; Region: HisKA_3; pfam07730 324057017544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017545 ATP binding site [chemical binding]; other site 324057017546 Mg2+ binding site [ion binding]; other site 324057017547 G-X-G motif; other site 324057017548 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057017549 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057017550 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057017551 Bacterial Ig-like domain; Region: Big_5; cl01012 324057017552 Bacterial Ig-like domain; Region: Big_5; cl01012 324057017553 Bacterial Ig-like domain; Region: Big_5; cl01012 324057017554 Bacterial Ig-like domain; Region: Big_5; cl01012 324057017555 Bacterial Ig-like domain; Region: Big_5; cl01012 324057017556 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 324057017557 S-layer homology domain; Region: SLH; pfam00395 324057017558 S-layer homology domain; Region: SLH; pfam00395 324057017559 S-layer homology domain; Region: SLH; pfam00395 324057017560 S-adenosylmethionine synthetase; Validated; Region: PRK05250 324057017561 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 324057017562 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 324057017563 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 324057017564 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057017565 S-layer homology domain; Region: SLH; pfam00395 324057017566 S-layer homology domain; Region: SLH; pfam00395 324057017567 S-layer homology domain; Region: SLH; pfam00395 324057017568 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 324057017569 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324057017570 Mg++ binding site [ion binding]; other site 324057017571 putative catalytic motif [active] 324057017572 substrate binding site [chemical binding]; other site 324057017573 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 324057017574 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324057017575 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 324057017576 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 324057017577 active site 324057017578 substrate binding site [chemical binding]; other site 324057017579 metal binding site [ion binding]; metal-binding site 324057017580 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 324057017581 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057017582 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 324057017583 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 324057017584 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 324057017585 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 324057017586 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 324057017587 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 324057017588 rod shape-determining protein Mbl; Provisional; Region: PRK13928 324057017589 Cell division protein FtsA; Region: FtsA; cl11496 324057017590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057017591 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057017592 stage II sporulation protein D; Region: spore_II_D; TIGR02870 324057017593 Stage II sporulation protein; Region: SpoIID; pfam08486 324057017594 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324057017595 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 324057017596 FtsX-like permease family; Region: FtsX; cl15850 324057017597 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057017598 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057017599 Walker A/P-loop; other site 324057017600 ATP binding site [chemical binding]; other site 324057017601 Q-loop/lid; other site 324057017602 ABC transporter signature motif; other site 324057017603 Walker B; other site 324057017604 D-loop; other site 324057017605 H-loop/switch region; other site 324057017606 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 324057017607 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057017608 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057017609 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057017610 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057017611 hinge; other site 324057017612 active site 324057017613 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 324057017614 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 324057017615 active site 324057017616 catalytic residues [active] 324057017617 S-layer homology domain; Region: SLH; pfam00395 324057017618 S-layer homology domain; Region: SLH; pfam00395 324057017619 S-layer homology domain; Region: SLH; pfam00395 324057017620 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 324057017621 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 324057017622 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 324057017623 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 324057017624 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 324057017625 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 324057017626 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 324057017627 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 324057017628 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 324057017629 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 324057017630 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 324057017631 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 324057017632 4Fe-4S binding domain; Region: Fer4; cl02805 324057017633 4Fe-4S binding domain; Region: Fer4; cl02805 324057017634 NADH dehydrogenase; Region: NADHdh; cl00469 324057017635 NADH dehydrogenase subunit B; Validated; Region: PRK06411 324057017636 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 324057017637 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 324057017638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057017639 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057017640 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057017641 dimer interface [polypeptide binding]; other site 324057017642 putative CheW interface [polypeptide binding]; other site 324057017643 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057017644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057017645 ABC-ATPase subunit interface; other site 324057017646 dimer interface [polypeptide binding]; other site 324057017647 putative PBP binding regions; other site 324057017648 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057017649 ABC-ATPase subunit interface; other site 324057017650 dimer interface [polypeptide binding]; other site 324057017651 putative PBP binding regions; other site 324057017652 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057017653 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057017654 siderophore binding site; other site 324057017655 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 324057017656 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 324057017657 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 324057017658 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 324057017659 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 324057017660 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 324057017661 alpha subunit interaction interface [polypeptide binding]; other site 324057017662 Walker A motif; other site 324057017663 ATP binding site [chemical binding]; other site 324057017664 Walker B motif; other site 324057017665 inhibitor binding site; inhibition site 324057017666 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324057017667 ATP synthase; Region: ATP-synt; cl00365 324057017668 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 324057017669 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 324057017670 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 324057017671 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 324057017672 beta subunit interaction interface [polypeptide binding]; other site 324057017673 Walker A motif; other site 324057017674 ATP binding site [chemical binding]; other site 324057017675 Walker B motif; other site 324057017676 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324057017677 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 324057017678 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 324057017679 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 324057017680 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 324057017681 ATP synthase subunit C; Region: ATP-synt_C; cl00466 324057017682 ATP synthase A chain; Region: ATP-synt_A; cl00413 324057017683 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 324057017684 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 324057017685 active site 324057017686 homodimer interface [polypeptide binding]; other site 324057017687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057017688 active site 324057017689 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 324057017690 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057017691 Walker A/P-loop; other site 324057017692 ATP binding site [chemical binding]; other site 324057017693 Q-loop/lid; other site 324057017694 ABC transporter signature motif; other site 324057017695 Walker B; other site 324057017696 D-loop; other site 324057017697 H-loop/switch region; other site 324057017698 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057017699 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057017700 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 324057017701 Walker A/P-loop; other site 324057017702 ATP binding site [chemical binding]; other site 324057017703 Q-loop/lid; other site 324057017704 ABC transporter signature motif; other site 324057017705 Walker B; other site 324057017706 D-loop; other site 324057017707 H-loop/switch region; other site 324057017708 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057017709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057017710 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324057017711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017712 dimer interface [polypeptide binding]; other site 324057017713 conserved gate region; other site 324057017714 putative PBP binding loops; other site 324057017715 ABC-ATPase subunit interface; other site 324057017716 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 324057017717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017718 dimer interface [polypeptide binding]; other site 324057017719 conserved gate region; other site 324057017720 putative PBP binding loops; other site 324057017721 ABC-ATPase subunit interface; other site 324057017722 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 324057017723 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 324057017724 peptide binding site [polypeptide binding]; other site 324057017725 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 324057017726 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 324057017727 dimer interface [polypeptide binding]; other site 324057017728 active site 324057017729 glycine-pyridoxal phosphate binding site [chemical binding]; other site 324057017730 folate binding site [chemical binding]; other site 324057017731 Protein of unknown function (DUF436); Region: DUF436; cl01860 324057017732 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 324057017733 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324057017734 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 324057017735 active site 324057017736 Predicted membrane protein [Function unknown]; Region: COG1971 324057017737 Domain of unknown function DUF; Region: DUF204; pfam02659 324057017738 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 324057017739 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 324057017740 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 324057017741 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 324057017742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057017743 peptide chain release factor 1; Validated; Region: prfA; PRK00591 324057017744 RF-1 domain; Region: RF-1; cl02875 324057017745 RF-1 domain; Region: RF-1; cl02875 324057017746 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 324057017747 Bacterial Ig-like domain; Region: Big_5; cl01012 324057017748 Copper resistance protein D; Region: CopD; cl00563 324057017749 GTP-binding protein YchF; Reviewed; Region: PRK09601 324057017750 YchF GTPase; Region: YchF; cd01900 324057017751 G1 box; other site 324057017752 GTP/Mg2+ binding site [chemical binding]; other site 324057017753 Switch I region; other site 324057017754 G2 box; other site 324057017755 Switch II region; other site 324057017756 G3 box; other site 324057017757 G4 box; other site 324057017758 G5 box; other site 324057017759 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 324057017760 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057017761 Probable Catalytic site; other site 324057017762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057017763 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 324057017764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057017765 S-adenosylmethionine binding site [chemical binding]; other site 324057017766 S-layer homology domain; Region: SLH; pfam00395 324057017767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017769 dimer interface [polypeptide binding]; other site 324057017770 conserved gate region; other site 324057017771 putative PBP binding loops; other site 324057017772 ABC-ATPase subunit interface; other site 324057017773 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017775 dimer interface [polypeptide binding]; other site 324057017776 conserved gate region; other site 324057017777 putative PBP binding loops; other site 324057017778 ABC-ATPase subunit interface; other site 324057017779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057017781 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057017782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017783 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057017784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017785 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 324057017786 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 324057017787 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057017788 Cupin domain; Region: Cupin_2; cl09118 324057017789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017790 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057017791 catalytic residues [active] 324057017792 Helix-turn-helix domains; Region: HTH; cl00088 324057017793 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057017794 Helix-turn-helix domains; Region: HTH; cl00088 324057017795 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 324057017796 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 324057017797 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324057017798 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057017799 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324057017800 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 324057017801 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057017802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057017803 homodimer interface [polypeptide binding]; other site 324057017804 catalytic residue [active] 324057017805 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 324057017806 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057017807 RDD family; Region: RDD; cl00746 324057017808 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 324057017809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057017810 active site 324057017811 HIGH motif; other site 324057017812 nucleotide binding site [chemical binding]; other site 324057017813 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 324057017814 KMSKS motif; other site 324057017815 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 324057017816 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 324057017817 Na2 binding site [ion binding]; other site 324057017818 putative substrate binding site 1 [chemical binding]; other site 324057017819 Na binding site 1 [ion binding]; other site 324057017820 putative substrate binding site 2 [chemical binding]; other site 324057017821 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057017822 active site 324057017823 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057017824 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057017825 putative metal binding site; other site 324057017826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057017827 binding surface 324057017828 TPR motif; other site 324057017829 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057017830 putative metal binding site; other site 324057017831 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 324057017832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057017833 binding surface 324057017834 TPR motif; other site 324057017835 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057017836 putative metal binding site; other site 324057017837 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 324057017838 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324057017839 catalytic residues [active] 324057017840 dimer interface [polypeptide binding]; other site 324057017841 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 324057017842 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057017843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057017844 active site 324057017845 catalytic tetrad [active] 324057017846 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057017847 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 324057017848 tetramer interface [polypeptide binding]; other site 324057017849 heme binding pocket [chemical binding]; other site 324057017850 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057017851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057017852 DNA binding site [nucleotide binding] 324057017853 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057017854 metal binding site 2 [ion binding]; metal-binding site 324057017855 putative DNA binding helix; other site 324057017856 metal binding site 1 [ion binding]; metal-binding site 324057017857 dimer interface [polypeptide binding]; other site 324057017858 structural Zn2+ binding site [ion binding]; other site 324057017859 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 324057017860 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 324057017861 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 324057017862 putative active site [active] 324057017863 catalytic site [active] 324057017864 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 324057017865 putative active site [active] 324057017866 catalytic site [active] 324057017867 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 324057017868 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 324057017869 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 324057017870 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 324057017871 active site 324057017872 dimerization interface [polypeptide binding]; other site 324057017873 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 324057017874 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 324057017875 PT repeat; Region: PT; pfam04886 324057017876 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 324057017877 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057017878 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 324057017879 Sulfatase; Region: Sulfatase; cl10460 324057017880 S-layer homology domain; Region: SLH; pfam00395 324057017881 S-layer homology domain; Region: SLH; pfam00395 324057017882 S-layer homology domain; Region: SLH; pfam00395 324057017883 S-layer homology domain; Region: SLH; pfam00395 324057017884 S-layer homology domain; Region: SLH; pfam00395 324057017885 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057017886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057017887 active site 324057017888 catalytic tetrad [active] 324057017889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017890 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057017891 active site 324057017892 metal binding site [ion binding]; metal-binding site 324057017893 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 324057017894 catalytic triad [active] 324057017895 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 324057017896 active site 324057017897 homodimer interface [polypeptide binding]; other site 324057017898 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 324057017899 Amidase; Region: Amidase; cl11426 324057017900 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 324057017901 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 324057017902 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057017903 Helix-turn-helix domains; Region: HTH; cl00088 324057017904 AsnC family; Region: AsnC_trans_reg; pfam01037 324057017905 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 324057017906 Chromate transporter; Region: Chromate_transp; pfam02417 324057017907 Chromate transporter; Region: Chromate_transp; pfam02417 324057017908 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 324057017909 Predicted membrane protein [Function unknown]; Region: COG1511 324057017910 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 324057017911 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324057017912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057017913 Helix-turn-helix domains; Region: HTH; cl00088 324057017914 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057017915 FAD dependent oxidoreductase; Region: DAO; pfam01266 324057017916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057017918 dimerization interface [polypeptide binding]; other site 324057017919 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057017920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057017921 dimer interface [polypeptide binding]; other site 324057017922 putative CheW interface [polypeptide binding]; other site 324057017923 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057017924 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 324057017925 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 324057017926 Walker A/P-loop; other site 324057017927 ATP binding site [chemical binding]; other site 324057017928 Q-loop/lid; other site 324057017929 ABC transporter signature motif; other site 324057017930 Walker B; other site 324057017931 D-loop; other site 324057017932 H-loop/switch region; other site 324057017933 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 324057017934 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 324057017935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057017936 Walker A/P-loop; other site 324057017937 ATP binding site [chemical binding]; other site 324057017938 Q-loop/lid; other site 324057017939 ABC transporter signature motif; other site 324057017940 Walker B; other site 324057017941 D-loop; other site 324057017942 H-loop/switch region; other site 324057017943 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 324057017944 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 324057017945 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 324057017946 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 324057017947 [2Fe-2S] cluster binding site [ion binding]; other site 324057017948 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 324057017949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057017950 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 324057017951 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 324057017952 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324057017953 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 324057017954 ANTAR domain; Region: ANTAR; cl04297 324057017955 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 324057017956 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324057017957 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324057017958 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 324057017959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057017960 putative substrate translocation pore; other site 324057017961 Cold-inducible protein YdjO; Region: YdjO; pfam14169 324057017962 Cupin domain; Region: Cupin_2; cl09118 324057017963 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 324057017964 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 324057017965 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 324057017966 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057017967 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 324057017968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057017969 Helix-turn-helix domains; Region: HTH; cl00088 324057017970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057017971 dimerization interface [polypeptide binding]; other site 324057017972 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 324057017973 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 324057017974 dimer interface [polypeptide binding]; other site 324057017975 active site 324057017976 catalytic residue [active] 324057017977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057017978 active site 324057017979 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 324057017980 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057017981 active site 324057017982 catalytic tetrad [active] 324057017983 Helix-turn-helix domains; Region: HTH; cl00088 324057017984 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057017985 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324057017986 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324057017987 catalytic residues [active] 324057017988 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 324057017989 active site 1 [active] 324057017990 dimer interface [polypeptide binding]; other site 324057017991 hexamer interface [polypeptide binding]; other site 324057017992 active site 2 [active] 324057017993 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 324057017994 Helix-turn-helix domains; Region: HTH; cl00088 324057017995 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 324057017996 putative dimerization interface [polypeptide binding]; other site 324057017997 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 324057017998 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 324057017999 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 324057018000 G1 box; other site 324057018001 putative GEF interaction site [polypeptide binding]; other site 324057018002 GTP/Mg2+ binding site [chemical binding]; other site 324057018003 Switch I region; other site 324057018004 G2 box; other site 324057018005 G3 box; other site 324057018006 Switch II region; other site 324057018007 G4 box; other site 324057018008 G5 box; other site 324057018009 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324057018010 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 324057018011 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 324057018012 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 324057018013 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 324057018014 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 324057018015 active site 324057018016 metal binding site [ion binding]; metal-binding site 324057018017 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057018018 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057018019 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324057018020 active site 324057018021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057018022 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057018023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057018024 putative active site [active] 324057018025 heme pocket [chemical binding]; other site 324057018026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057018027 dimer interface [polypeptide binding]; other site 324057018028 phosphorylation site [posttranslational modification] 324057018029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018030 ATP binding site [chemical binding]; other site 324057018031 Mg2+ binding site [ion binding]; other site 324057018032 G-X-G motif; other site 324057018033 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057018034 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057018035 Walker A/P-loop; other site 324057018036 ATP binding site [chemical binding]; other site 324057018037 Q-loop/lid; other site 324057018038 ABC transporter signature motif; other site 324057018039 Walker B; other site 324057018040 D-loop; other site 324057018041 H-loop/switch region; other site 324057018042 FtsX-like permease family; Region: FtsX; cl15850 324057018043 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057018044 FtsX-like permease family; Region: FtsX; cl15850 324057018045 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057018046 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057018047 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324057018048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057018049 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057018050 Walker A/P-loop; other site 324057018051 ATP binding site [chemical binding]; other site 324057018052 Q-loop/lid; other site 324057018053 ABC transporter signature motif; other site 324057018054 Walker B; other site 324057018055 D-loop; other site 324057018056 H-loop/switch region; other site 324057018057 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 324057018058 trimer interface [polypeptide binding]; other site 324057018059 active site 324057018060 substrate binding site [chemical binding]; other site 324057018061 CoA binding site [chemical binding]; other site 324057018062 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324057018063 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324057018064 synthetase active site [active] 324057018065 NTP binding site [chemical binding]; other site 324057018066 metal binding site [ion binding]; metal-binding site 324057018067 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 324057018068 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 324057018069 Uncharacterized conserved protein [Function unknown]; Region: COG2966 324057018070 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 324057018071 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057018072 MatE; Region: MatE; cl10513 324057018073 MatE; Region: MatE; cl10513 324057018074 Helix-turn-helix domains; Region: HTH; cl00088 324057018075 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057018076 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057018077 Response regulator receiver domain; Region: Response_reg; pfam00072 324057018078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018079 active site 324057018080 phosphorylation site [posttranslational modification] 324057018081 intermolecular recognition site; other site 324057018082 dimerization interface [polypeptide binding]; other site 324057018083 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057018084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057018087 Histidine kinase; Region: His_kinase; pfam06580 324057018088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018089 ATP binding site [chemical binding]; other site 324057018090 Mg2+ binding site [ion binding]; other site 324057018091 G-X-G motif; other site 324057018092 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018094 dimer interface [polypeptide binding]; other site 324057018095 conserved gate region; other site 324057018096 putative PBP binding loops; other site 324057018097 ABC-ATPase subunit interface; other site 324057018098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018099 dimer interface [polypeptide binding]; other site 324057018100 conserved gate region; other site 324057018101 putative PBP binding loops; other site 324057018102 ABC-ATPase subunit interface; other site 324057018103 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057018105 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057018106 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057018107 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324057018108 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057018109 NAD binding site [chemical binding]; other site 324057018110 substrate binding site [chemical binding]; other site 324057018111 putative active site [active] 324057018112 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324057018113 catalytic residues [active] 324057018114 dimer interface [polypeptide binding]; other site 324057018115 Helix-turn-helix domains; Region: HTH; cl00088 324057018116 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057018117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057018118 DNA-binding site [nucleotide binding]; DNA binding site 324057018119 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057018120 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 324057018121 Walker A/P-loop; other site 324057018122 ATP binding site [chemical binding]; other site 324057018123 Q-loop/lid; other site 324057018124 ABC transporter signature motif; other site 324057018125 Walker B; other site 324057018126 D-loop; other site 324057018127 H-loop/switch region; other site 324057018128 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 324057018129 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 324057018130 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 324057018131 NAD binding site [chemical binding]; other site 324057018132 Phe binding site; other site 324057018133 peptidase T; Region: peptidase-T; TIGR01882 324057018134 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 324057018135 metal binding site [ion binding]; metal-binding site 324057018136 dimer interface [polypeptide binding]; other site 324057018137 Flavin Reductases; Region: FlaRed; cl00801 324057018138 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057018139 Predicted esterase [General function prediction only]; Region: COG0400 324057018140 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 324057018141 nucleophilic elbow; other site 324057018142 catalytic triad; other site 324057018143 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 324057018144 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057018145 Zn binding site [ion binding]; other site 324057018146 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 324057018147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057018148 Zn binding site [ion binding]; other site 324057018149 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057018150 Helix-turn-helix domains; Region: HTH; cl00088 324057018151 Helix-turn-helix domains; Region: HTH; cl00088 324057018152 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 324057018153 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 324057018154 Predicted acetyltransferase [General function prediction only]; Region: COG3393 324057018155 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 324057018156 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057018157 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 324057018158 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324057018159 DNA binding site [nucleotide binding] 324057018160 active site 324057018161 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057018162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018163 putative substrate translocation pore; other site 324057018164 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 324057018165 NAD(P) binding site [chemical binding]; other site 324057018166 catalytic residues [active] 324057018167 YhhN-like protein; Region: YhhN; cl01505 324057018168 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 324057018169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057018170 FeS/SAM binding site; other site 324057018171 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 324057018172 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 324057018173 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057018174 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 324057018175 K+-transporting ATPase, c chain; Region: KdpC; cl00944 324057018176 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 324057018177 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 324057018178 Ligand Binding Site [chemical binding]; other site 324057018179 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 324057018180 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 324057018181 Ligand Binding Site [chemical binding]; other site 324057018182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057018183 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057018184 NAD(P) binding site [chemical binding]; other site 324057018185 active site 324057018186 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057018187 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057018188 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057018189 putative ligand binding residues [chemical binding]; other site 324057018190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057018191 ABC-ATPase subunit interface; other site 324057018192 dimer interface [polypeptide binding]; other site 324057018193 putative PBP binding regions; other site 324057018194 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057018195 ABC-ATPase subunit interface; other site 324057018196 dimer interface [polypeptide binding]; other site 324057018197 putative PBP binding regions; other site 324057018198 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 324057018199 Helix-turn-helix domains; Region: HTH; cl00088 324057018200 WYL domain; Region: WYL; cl14852 324057018201 Sulfatase; Region: Sulfatase; cl10460 324057018202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018203 Helix-turn-helix domains; Region: HTH; cl00088 324057018204 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 324057018205 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 324057018206 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 324057018207 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057018208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018209 putative substrate translocation pore; other site 324057018210 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057018211 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057018212 DNA binding residues [nucleotide binding] 324057018213 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057018214 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 324057018215 NADP binding site [chemical binding]; other site 324057018216 dimer interface [polypeptide binding]; other site 324057018217 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057018218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057018219 DNA-binding site [nucleotide binding]; DNA binding site 324057018220 FCD domain; Region: FCD; cl11656 324057018221 NMT1-like family; Region: NMT1_2; cl15260 324057018222 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 324057018223 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057018224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018225 dimer interface [polypeptide binding]; other site 324057018226 conserved gate region; other site 324057018227 putative PBP binding loops; other site 324057018228 ABC-ATPase subunit interface; other site 324057018229 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057018230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057018231 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 324057018232 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 324057018233 Walker A/P-loop; other site 324057018234 ATP binding site [chemical binding]; other site 324057018235 Q-loop/lid; other site 324057018236 ABC transporter signature motif; other site 324057018237 Walker B; other site 324057018238 D-loop; other site 324057018239 H-loop/switch region; other site 324057018240 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 324057018241 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 324057018242 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057018243 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057018244 active site 324057018245 ATP binding site [chemical binding]; other site 324057018246 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057018247 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057018248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057018249 short chain dehydrogenase; Provisional; Region: PRK06180 324057018250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057018251 NAD(P) binding site [chemical binding]; other site 324057018252 active site 324057018253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018254 Helix-turn-helix domains; Region: HTH; cl00088 324057018255 HSP90 family protein; Provisional; Region: PRK14083 324057018256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018257 ATP binding site [chemical binding]; other site 324057018258 Mg2+ binding site [ion binding]; other site 324057018259 G-X-G motif; other site 324057018260 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 324057018261 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 324057018262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057018263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057018264 dimer interface [polypeptide binding]; other site 324057018265 phosphorylation site [posttranslational modification] 324057018266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018267 ATP binding site [chemical binding]; other site 324057018268 Mg2+ binding site [ion binding]; other site 324057018269 G-X-G motif; other site 324057018270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057018271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018272 active site 324057018273 phosphorylation site [posttranslational modification] 324057018274 intermolecular recognition site; other site 324057018275 dimerization interface [polypeptide binding]; other site 324057018276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057018277 DNA binding site [nucleotide binding] 324057018278 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057018279 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057018280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018281 Helix-turn-helix domains; Region: HTH; cl00088 324057018282 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057018283 Phosphotransferase enzyme family; Region: APH; pfam01636 324057018284 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057018285 active site 324057018286 ATP binding site [chemical binding]; other site 324057018287 substrate binding site [chemical binding]; other site 324057018288 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 324057018289 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057018290 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057018291 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324057018292 catalytic residues [active] 324057018293 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 324057018294 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 324057018295 S-layer homology domain; Region: SLH; pfam00395 324057018296 S-layer homology domain; Region: SLH; pfam00395 324057018297 S-layer homology domain; Region: SLH; pfam00395 324057018298 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 324057018299 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 324057018300 Phosphotransferase enzyme family; Region: APH; pfam01636 324057018301 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 324057018302 active site 324057018303 substrate binding site [chemical binding]; other site 324057018304 ATP binding site [chemical binding]; other site 324057018305 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 324057018306 MFS transport protein AraJ; Provisional; Region: PRK10091 324057018307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018308 putative substrate translocation pore; other site 324057018309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057018310 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057018311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057018312 dimer interface [polypeptide binding]; other site 324057018313 phosphorylation site [posttranslational modification] 324057018314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018315 ATP binding site [chemical binding]; other site 324057018316 Mg2+ binding site [ion binding]; other site 324057018317 G-X-G motif; other site 324057018318 sensory histidine kinase AtoS; Provisional; Region: PRK11360 324057018319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057018320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057018321 metal binding site [ion binding]; metal-binding site 324057018322 active site 324057018323 I-site; other site 324057018324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057018325 S-adenosylmethionine binding site [chemical binding]; other site 324057018326 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057018327 Helix-turn-helix domains; Region: HTH; cl00088 324057018328 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057018329 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057018330 classical (c) SDRs; Region: SDR_c; cd05233 324057018331 NAD(P) binding site [chemical binding]; other site 324057018332 active site 324057018333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057018334 Helix-turn-helix domains; Region: HTH; cl00088 324057018335 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057018336 dimerization interface [polypeptide binding]; other site 324057018337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057018339 putative substrate translocation pore; other site 324057018340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057018341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018342 active site 324057018343 phosphorylation site [posttranslational modification] 324057018344 intermolecular recognition site; other site 324057018345 dimerization interface [polypeptide binding]; other site 324057018346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057018347 DNA binding site [nucleotide binding] 324057018348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057018349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 324057018350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018351 ATP binding site [chemical binding]; other site 324057018352 Mg2+ binding site [ion binding]; other site 324057018353 G-X-G motif; other site 324057018354 FtsX-like permease family; Region: FtsX; cl15850 324057018355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057018356 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 324057018357 Walker A/P-loop; other site 324057018358 ATP binding site [chemical binding]; other site 324057018359 Q-loop/lid; other site 324057018360 ABC transporter signature motif; other site 324057018361 Walker B; other site 324057018362 D-loop; other site 324057018363 H-loop/switch region; other site 324057018364 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057018365 active site 324057018366 catalytic triad [active] 324057018367 oxyanion hole [active] 324057018368 hypothetical protein; Provisional; Region: PRK08185 324057018369 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 324057018370 intersubunit interface [polypeptide binding]; other site 324057018371 active site 324057018372 zinc binding site [ion binding]; other site 324057018373 Na+ binding site [ion binding]; other site 324057018374 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 324057018375 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 324057018376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018377 binding surface 324057018378 TPR motif; other site 324057018379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057018380 binding surface 324057018381 TPR motif; other site 324057018382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018383 binding surface 324057018384 TPR motif; other site 324057018385 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324057018386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018387 TPR motif; other site 324057018388 binding surface 324057018389 TPR repeat; Region: TPR_11; pfam13414 324057018390 TPR repeat; Region: TPR_11; pfam13414 324057018391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018392 binding surface 324057018393 TPR motif; other site 324057018394 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 324057018395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018396 binding surface 324057018397 TPR motif; other site 324057018398 TPR repeat; Region: TPR_11; pfam13414 324057018399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018400 binding surface 324057018401 TPR motif; other site 324057018402 Predicted membrane protein [Function unknown]; Region: COG1511 324057018403 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057018404 ABC-2 type transporter; Region: ABC2_membrane; cl11417 324057018405 S-layer homology domain; Region: SLH; pfam00395 324057018406 S-layer homology domain; Region: SLH; pfam00395 324057018407 S-layer homology domain; Region: SLH; pfam00395 324057018408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057018409 DNA-binding site [nucleotide binding]; DNA binding site 324057018410 FCD domain; Region: FCD; cl11656 324057018411 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057018412 active site 324057018413 metal binding site [ion binding]; metal-binding site 324057018414 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 324057018415 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057018416 active site 324057018417 metal binding site [ion binding]; metal-binding site 324057018418 hexamer interface [polypeptide binding]; other site 324057018419 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 324057018420 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 324057018421 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057018422 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057018424 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057018425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018426 dimer interface [polypeptide binding]; other site 324057018427 conserved gate region; other site 324057018428 ABC-ATPase subunit interface; other site 324057018429 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018431 dimer interface [polypeptide binding]; other site 324057018432 conserved gate region; other site 324057018433 putative PBP binding loops; other site 324057018434 ABC-ATPase subunit interface; other site 324057018435 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 324057018436 DHHW protein; Region: DHHW; pfam14286 324057018437 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 324057018438 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 324057018439 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057018440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057018441 Helix-turn-helix domains; Region: HTH; cl00088 324057018442 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057018443 dimerization interface [polypeptide binding]; other site 324057018444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057018445 classical (c) SDRs; Region: SDR_c; cd05233 324057018446 NAD(P) binding site [chemical binding]; other site 324057018447 active site 324057018448 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 324057018449 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057018450 Spore germination protein; Region: Spore_permease; cl15802 324057018451 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057018452 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 324057018453 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057018454 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057018455 Fibronectin type III-like domain; Region: Fn3-like; cl15273 324057018456 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 324057018457 putative active site [active] 324057018458 metal binding site [ion binding]; metal-binding site 324057018459 Predicted esterase [General function prediction only]; Region: COG0400 324057018460 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 324057018461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057018462 non-specific DNA binding site [nucleotide binding]; other site 324057018463 salt bridge; other site 324057018464 sequence-specific DNA binding site [nucleotide binding]; other site 324057018465 Cupin domain; Region: Cupin_2; cl09118 324057018466 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057018467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018468 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057018469 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057018470 putative ligand binding residues [chemical binding]; other site 324057018471 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 324057018472 DinB superfamily; Region: DinB_2; pfam12867 324057018473 Protein of unknown function (DUF419); Region: DUF419; cl15265 324057018474 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057018475 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 324057018476 putative hydrophobic ligand binding site [chemical binding]; other site 324057018477 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057018478 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 324057018479 putative hydrophobic ligand binding site [chemical binding]; other site 324057018480 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 324057018481 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057018482 DNA binding residues [nucleotide binding] 324057018483 putative dimer interface [polypeptide binding]; other site 324057018484 FtsX-like permease family; Region: FtsX; cl15850 324057018485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057018486 classical (c) SDRs; Region: SDR_c; cd05233 324057018487 NAD(P) binding site [chemical binding]; other site 324057018488 active site 324057018489 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 324057018490 classical (c) SDRs; Region: SDR_c; cd05233 324057018491 NAD(P) binding site [chemical binding]; other site 324057018492 active site 324057018493 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057018494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057018495 DNA-binding site [nucleotide binding]; DNA binding site 324057018496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057018497 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 324057018498 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 324057018499 putative metal binding residues [ion binding]; other site 324057018500 signature motif; other site 324057018501 dimer interface [polypeptide binding]; other site 324057018502 active site 324057018503 polyP binding site; other site 324057018504 substrate binding site [chemical binding]; other site 324057018505 acceptor-phosphate pocket; other site 324057018506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057018507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018508 active site 324057018509 phosphorylation site [posttranslational modification] 324057018510 intermolecular recognition site; other site 324057018511 dimerization interface [polypeptide binding]; other site 324057018512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057018513 DNA binding site [nucleotide binding] 324057018514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057018515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057018516 dimer interface [polypeptide binding]; other site 324057018517 phosphorylation site [posttranslational modification] 324057018518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018519 ATP binding site [chemical binding]; other site 324057018520 Mg2+ binding site [ion binding]; other site 324057018521 G-X-G motif; other site 324057018522 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057018523 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324057018524 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324057018525 Ligand binding site; other site 324057018526 Putative Catalytic site; other site 324057018527 DXD motif; other site 324057018528 GtrA-like protein; Region: GtrA; cl00971 324057018529 short chain dehydrogenase; Provisional; Region: PRK06180 324057018530 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057018531 NADP binding site [chemical binding]; other site 324057018532 active site 324057018533 steroid binding site; other site 324057018534 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057018535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057018537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057018539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018540 active site 324057018541 phosphorylation site [posttranslational modification] 324057018542 intermolecular recognition site; other site 324057018543 dimerization interface [polypeptide binding]; other site 324057018544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057018545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018546 ATP binding site [chemical binding]; other site 324057018547 Mg2+ binding site [ion binding]; other site 324057018548 G-X-G motif; other site 324057018549 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057018551 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057018552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018553 dimer interface [polypeptide binding]; other site 324057018554 ABC-ATPase subunit interface; other site 324057018555 putative PBP binding loops; other site 324057018556 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018558 dimer interface [polypeptide binding]; other site 324057018559 conserved gate region; other site 324057018560 putative PBP binding loops; other site 324057018561 ABC-ATPase subunit interface; other site 324057018562 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 324057018563 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057018564 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057018565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057018566 DDE superfamily endonuclease; Region: DDE_4; cl15789 324057018567 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 324057018568 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 324057018569 metal binding site [ion binding]; metal-binding site 324057018570 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 324057018571 active site flap/lid [active] 324057018572 nucleophilic elbow; other site 324057018573 catalytic triad [active] 324057018574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 324057018575 Chitin binding domain; Region: Chitin_bind_3; cl03871 324057018576 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057018577 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 324057018578 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057018579 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 324057018580 chitin/cellulose binding site [chemical binding]; other site 324057018581 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 324057018582 chitin/cellulose binding site [chemical binding]; other site 324057018583 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057018584 Helix-turn-helix domains; Region: HTH; cl00088 324057018585 WYL domain; Region: WYL; cl14852 324057018586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018587 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057018588 putative substrate translocation pore; other site 324057018589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 324057018590 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 324057018591 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057018592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057018593 Coenzyme A binding pocket [chemical binding]; other site 324057018594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057018595 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 324057018596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057018597 PAS domain; Region: PAS_9; pfam13426 324057018598 putative active site [active] 324057018599 heme pocket [chemical binding]; other site 324057018600 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057018601 dimer interface [polypeptide binding]; other site 324057018602 putative CheW interface [polypeptide binding]; other site 324057018603 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 324057018604 DNA binding residues [nucleotide binding] 324057018605 B12 binding domain; Region: B12-binding_2; cl03653 324057018606 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 324057018607 B12 binding site [chemical binding]; other site 324057018608 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 324057018609 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057018610 putative NAD(P) binding site [chemical binding]; other site 324057018611 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057018612 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057018613 DNA binding residues [nucleotide binding] 324057018614 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 324057018615 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 324057018616 G1 box; other site 324057018617 putative GEF interaction site [polypeptide binding]; other site 324057018618 GTP/Mg2+ binding site [chemical binding]; other site 324057018619 Switch I region; other site 324057018620 G2 box; other site 324057018621 G3 box; other site 324057018622 Switch II region; other site 324057018623 G4 box; other site 324057018624 G5 box; other site 324057018625 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324057018626 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 324057018627 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 324057018628 MFS/sugar transport protein; Region: MFS_2; pfam13347 324057018629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018630 putative substrate translocation pore; other site 324057018631 cytosine deaminase; Provisional; Region: PRK09230 324057018632 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057018633 active site 324057018634 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324057018635 NMT1-like family; Region: NMT1_2; cl15260 324057018636 NMT1/THI5 like; Region: NMT1; pfam09084 324057018637 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057018638 cytosine deaminase; Provisional; Region: PRK05985 324057018639 active site 324057018640 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057018641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057018642 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324057018643 FAD binding domain; Region: FAD_binding_4; pfam01565 324057018644 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057018645 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057018646 Walker A/P-loop; other site 324057018647 ATP binding site [chemical binding]; other site 324057018648 Q-loop/lid; other site 324057018649 ABC transporter signature motif; other site 324057018650 Walker B; other site 324057018651 D-loop; other site 324057018652 H-loop/switch region; other site 324057018653 Creatinine amidohydrolase; Region: Creatininase; cl00618 324057018654 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057018655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057018656 DNA-binding site [nucleotide binding]; DNA binding site 324057018657 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 324057018658 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057018659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057018660 non-specific DNA binding site [nucleotide binding]; other site 324057018661 salt bridge; other site 324057018662 sequence-specific DNA binding site [nucleotide binding]; other site 324057018663 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 324057018664 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 324057018665 TIGR02452 family protein; Region: TIGR02452 324057018666 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 324057018667 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057018668 nudix motif; other site 324057018669 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057018670 nudix motif; other site 324057018671 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 324057018672 putative active site [active] 324057018673 nucleotide binding site [chemical binding]; other site 324057018674 nudix motif; other site 324057018675 putative metal binding site [ion binding]; other site 324057018676 seryl-tRNA synthetase; Provisional; Region: PRK05431 324057018677 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 324057018678 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 324057018679 dimer interface [polypeptide binding]; other site 324057018680 active site 324057018681 motif 1; other site 324057018682 motif 2; other site 324057018683 motif 3; other site 324057018684 Response regulator receiver domain; Region: Response_reg; pfam00072 324057018685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018686 active site 324057018687 phosphorylation site [posttranslational modification] 324057018688 intermolecular recognition site; other site 324057018689 dimerization interface [polypeptide binding]; other site 324057018690 PAS domain S-box; Region: sensory_box; TIGR00229 324057018691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057018692 putative active site [active] 324057018693 heme pocket [chemical binding]; other site 324057018694 sensory histidine kinase AtoS; Provisional; Region: PRK11360 324057018695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057018696 dimer interface [polypeptide binding]; other site 324057018697 phosphorylation site [posttranslational modification] 324057018698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018699 ATP binding site [chemical binding]; other site 324057018700 Mg2+ binding site [ion binding]; other site 324057018701 G-X-G motif; other site 324057018702 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 324057018703 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 324057018704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057018705 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 324057018706 CHASE3 domain; Region: CHASE3; cl05000 324057018707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057018708 dimerization interface [polypeptide binding]; other site 324057018709 GAF domain; Region: GAF_2; pfam13185 324057018710 GAF domain; Region: GAF; cl15785 324057018711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 324057018712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018713 ATP binding site [chemical binding]; other site 324057018714 Mg2+ binding site [ion binding]; other site 324057018715 G-X-G motif; other site 324057018716 Response regulator receiver domain; Region: Response_reg; pfam00072 324057018717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018718 active site 324057018719 phosphorylation site [posttranslational modification] 324057018720 intermolecular recognition site; other site 324057018721 dimerization interface [polypeptide binding]; other site 324057018722 Uncharacterized conserved protein [Function unknown]; Region: COG2308 324057018723 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 324057018724 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 324057018725 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057018726 Cupin domain; Region: Cupin_2; cl09118 324057018727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057018729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018730 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 324057018731 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018734 dimer interface [polypeptide binding]; other site 324057018735 conserved gate region; other site 324057018736 putative PBP binding loops; other site 324057018737 ABC-ATPase subunit interface; other site 324057018738 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057018739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018740 dimer interface [polypeptide binding]; other site 324057018741 conserved gate region; other site 324057018742 ABC-ATPase subunit interface; other site 324057018743 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 324057018744 active site 324057018745 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 324057018746 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 324057018747 N- and C-terminal domain interface [polypeptide binding]; other site 324057018748 D-xylulose kinase; Region: XylB; TIGR01312 324057018749 active site 324057018750 catalytic site [active] 324057018751 metal binding site [ion binding]; metal-binding site 324057018752 xylulose binding site [chemical binding]; other site 324057018753 putative ATP binding site [chemical binding]; other site 324057018754 homodimer interface [polypeptide binding]; other site 324057018755 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057018756 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057018757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057018758 Predicted dehydrogenase [General function prediction only]; Region: COG0579 324057018759 Helix-turn-helix domains; Region: HTH; cl00088 324057018760 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324057018761 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057018762 NAD binding site [chemical binding]; other site 324057018763 substrate binding site [chemical binding]; other site 324057018764 putative active site [active] 324057018765 long-chain fatty acyl-ACP reductase (aldehyde-forming); Region: AcACP_reductase; TIGR04058 324057018766 YCII-related domain; Region: YCII; cl00999 324057018767 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057018768 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057018769 NodB motif; other site 324057018770 active site 324057018771 catalytic site [active] 324057018772 metal binding site [ion binding]; metal-binding site 324057018773 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 324057018774 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057018775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018776 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057018777 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057018778 intersubunit interface [polypeptide binding]; other site 324057018779 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057018780 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057018781 intersubunit interface [polypeptide binding]; other site 324057018782 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 324057018783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057018784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057018785 DNA binding residues [nucleotide binding] 324057018786 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 324057018787 active site 324057018788 putative catalytic site [active] 324057018789 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057018790 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 324057018791 Integral membrane protein TerC family; Region: TerC; cl10468 324057018792 Cupin domain; Region: Cupin_2; cl09118 324057018793 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 324057018794 A new structural DNA glycosylase; Region: AlkD_like; cd06561 324057018795 active site 324057018796 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057018797 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057018798 active site 324057018799 non-prolyl cis peptide bond; other site 324057018800 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057018801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018802 dimer interface [polypeptide binding]; other site 324057018803 conserved gate region; other site 324057018804 putative PBP binding loops; other site 324057018805 ABC-ATPase subunit interface; other site 324057018806 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057018807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018808 dimer interface [polypeptide binding]; other site 324057018809 conserved gate region; other site 324057018810 putative PBP binding loops; other site 324057018811 ABC-ATPase subunit interface; other site 324057018812 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057018813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057018814 substrate binding pocket [chemical binding]; other site 324057018815 membrane-bound complex binding site; other site 324057018816 hinge residues; other site 324057018817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057018818 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 324057018819 Walker A/P-loop; other site 324057018820 ATP binding site [chemical binding]; other site 324057018821 Q-loop/lid; other site 324057018822 ABC transporter signature motif; other site 324057018823 Walker B; other site 324057018824 D-loop; other site 324057018825 H-loop/switch region; other site 324057018826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018827 Helix-turn-helix domains; Region: HTH; cl00088 324057018828 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057018829 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 324057018830 NAD(P) binding site [chemical binding]; other site 324057018831 active site 324057018832 Helix-turn-helix domains; Region: HTH; cl00088 324057018833 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324057018834 dimer interface [polypeptide binding]; other site 324057018835 FMN binding site [chemical binding]; other site 324057018836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057018837 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057018838 Helix-turn-helix domains; Region: HTH; cl00088 324057018839 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 324057018840 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 324057018841 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 324057018842 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 324057018843 S-layer homology domain; Region: SLH; pfam00395 324057018844 S-layer homology domain; Region: SLH; pfam00395 324057018845 S-layer homology domain; Region: SLH; pfam00395 324057018846 Helix-turn-helix domains; Region: HTH; cl00088 324057018847 DoxX; Region: DoxX; cl00976 324057018848 short chain dehydrogenase; Provisional; Region: PRK06482 324057018849 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057018850 NADP binding site [chemical binding]; other site 324057018851 active site 324057018852 steroid binding site; other site 324057018853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018854 Helix-turn-helix domains; Region: HTH; cl00088 324057018855 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 324057018856 Phosphotransferase enzyme family; Region: APH; pfam01636 324057018857 putative active site [active] 324057018858 putative substrate binding site [chemical binding]; other site 324057018859 ATP binding site [chemical binding]; other site 324057018860 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 324057018861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057018862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 324057018863 DoxX; Region: DoxX; cl00976 324057018864 Response regulator receiver domain; Region: Response_reg; pfam00072 324057018865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018866 active site 324057018867 phosphorylation site [posttranslational modification] 324057018868 intermolecular recognition site; other site 324057018869 dimerization interface [polypeptide binding]; other site 324057018870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057018872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018873 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018875 dimer interface [polypeptide binding]; other site 324057018876 conserved gate region; other site 324057018877 putative PBP binding loops; other site 324057018878 ABC-ATPase subunit interface; other site 324057018879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018880 dimer interface [polypeptide binding]; other site 324057018881 conserved gate region; other site 324057018882 putative PBP binding loops; other site 324057018883 ABC-ATPase subunit interface; other site 324057018884 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057018886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057018887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057018888 dimerization interface [polypeptide binding]; other site 324057018889 Histidine kinase; Region: His_kinase; pfam06580 324057018890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018891 ATP binding site [chemical binding]; other site 324057018892 Mg2+ binding site [ion binding]; other site 324057018893 G-X-G motif; other site 324057018894 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 324057018895 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 324057018896 catalytic residue [active] 324057018897 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057018899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057018900 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 324057018901 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018903 dimer interface [polypeptide binding]; other site 324057018904 conserved gate region; other site 324057018905 putative PBP binding loops; other site 324057018906 ABC-ATPase subunit interface; other site 324057018907 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 324057018908 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 324057018909 putative active site cavity [active] 324057018910 N-acetylmannosamine kinase; Provisional; Region: PRK05082 324057018911 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 324057018912 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324057018913 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324057018914 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324057018915 putative active site [active] 324057018916 Domain of unknown function (DUF386); Region: DUF386; cl01047 324057018917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057018918 DNA binding residues [nucleotide binding] 324057018919 dimerization interface [polypeptide binding]; other site 324057018920 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 324057018921 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 324057018922 catalytic Zn binding site [ion binding]; other site 324057018923 NAD binding site [chemical binding]; other site 324057018924 structural Zn binding site [ion binding]; other site 324057018925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018926 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057018927 putative substrate translocation pore; other site 324057018928 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057018929 Helix-turn-helix domains; Region: HTH; cl00088 324057018930 WYL domain; Region: WYL; cl14852 324057018931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057018932 classical (c) SDRs; Region: SDR_c; cd05233 324057018933 NAD(P) binding site [chemical binding]; other site 324057018934 active site 324057018935 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057018936 dimerization domain swap beta strand [polypeptide binding]; other site 324057018937 regulatory protein interface [polypeptide binding]; other site 324057018938 active site 324057018939 regulatory phosphorylation site [posttranslational modification]; other site 324057018940 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324057018941 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324057018942 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 324057018943 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 324057018944 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 324057018945 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 324057018946 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 324057018947 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324057018948 active site 324057018949 phosphorylation site [posttranslational modification] 324057018950 Helix-turn-helix domains; Region: HTH; cl00088 324057018951 Helix-turn-helix domains; Region: HTH; cl00088 324057018952 PRD domain; Region: PRD; cl15445 324057018953 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 324057018954 active site 324057018955 P-loop; other site 324057018956 phosphorylation site [posttranslational modification] 324057018957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 324057018958 active site 324057018959 phosphorylation site [posttranslational modification] 324057018960 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 324057018961 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 324057018962 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 324057018963 active site 324057018964 P-loop; other site 324057018965 phosphorylation site [posttranslational modification] 324057018966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057018968 putative substrate translocation pore; other site 324057018969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018971 Helix-turn-helix domains; Region: HTH; cl00088 324057018972 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 324057018973 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 324057018974 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 324057018975 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 324057018976 Double zinc ribbon; Region: DZR; pfam12773 324057018977 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 324057018978 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 324057018979 Double zinc ribbon; Region: DZR; pfam12773 324057018980 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 324057018981 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057018982 MatE; Region: MatE; cl10513 324057018983 MatE; Region: MatE; cl10513 324057018984 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324057018985 FAD binding domain; Region: FAD_binding_4; pfam01565 324057018986 Berberine and berberine like; Region: BBE; pfam08031 324057018987 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 324057018988 putative catalytic site [active] 324057018989 putative metal binding site [ion binding]; other site 324057018990 putative phosphate binding site [ion binding]; other site 324057018991 GAF domain; Region: GAF; cl15785 324057018992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057018993 metal binding site [ion binding]; metal-binding site 324057018994 active site 324057018995 I-site; other site 324057018996 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018997 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057018998 Response regulator receiver domain; Region: Response_reg; pfam00072 324057018999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019000 active site 324057019001 phosphorylation site [posttranslational modification] 324057019002 intermolecular recognition site; other site 324057019003 dimerization interface [polypeptide binding]; other site 324057019004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057019005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019006 Histidine kinase; Region: His_kinase; pfam06580 324057019007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057019008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057019010 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057019011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057019013 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057019014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019015 dimer interface [polypeptide binding]; other site 324057019016 conserved gate region; other site 324057019017 putative PBP binding loops; other site 324057019018 ABC-ATPase subunit interface; other site 324057019019 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 324057019020 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 324057019021 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057019022 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 324057019023 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057019024 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057019025 YyzF-like protein; Region: YyzF; cl15733 324057019026 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 324057019027 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 324057019028 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057019029 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057019030 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 324057019031 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057019032 Helix-turn-helix domains; Region: HTH; cl00088 324057019033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057019034 YycH protein; Region: YycI; cl02015 324057019035 YycH protein; Region: YycH; pfam07435 324057019036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057019037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057019038 dimerization interface [polypeptide binding]; other site 324057019039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057019040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057019041 dimer interface [polypeptide binding]; other site 324057019042 phosphorylation site [posttranslational modification] 324057019043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019044 ATP binding site [chemical binding]; other site 324057019045 Mg2+ binding site [ion binding]; other site 324057019046 G-X-G motif; other site 324057019047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057019048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019049 active site 324057019050 phosphorylation site [posttranslational modification] 324057019051 intermolecular recognition site; other site 324057019052 dimerization interface [polypeptide binding]; other site 324057019053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057019054 DNA binding site [nucleotide binding] 324057019055 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057019056 G5 domain; Region: G5; pfam07501 324057019057 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057019058 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 324057019059 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 324057019060 GDP-binding site [chemical binding]; other site 324057019061 ACT binding site; other site 324057019062 IMP binding site; other site 324057019063 replicative DNA helicase; Provisional; Region: PRK05748 324057019064 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 324057019065 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 324057019066 Walker A motif; other site 324057019067 ATP binding site [chemical binding]; other site 324057019068 Walker B motif; other site 324057019069 DNA binding loops [nucleotide binding] 324057019070 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 324057019071 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 324057019072 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 324057019073 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 324057019074 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 324057019075 DHH family; Region: DHH; pfam01368 324057019076 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 324057019077 D-glutamate deacylase; Validated; Region: PRK09061 324057019078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057019079 active site 324057019080 FOG: CBS domain [General function prediction only]; Region: COG0517 324057019081 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 324057019082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800 324057019083 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 324057019084 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324057019085 Domain of unknown function DUF21; Region: DUF21; pfam01595 324057019086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324057019087 Transporter associated domain; Region: CorC_HlyC; cl08393 324057019088 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 324057019089 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 324057019090 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057019091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057019092 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 324057019093 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 324057019094 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 324057019095 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 324057019096 dimer interface [polypeptide binding]; other site 324057019097 ssDNA binding site [nucleotide binding]; other site 324057019098 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057019099 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 324057019100 YjzC-like protein; Region: YjzC; pfam14168 324057019101 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 324057019102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057019103 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 324057019104 Mechanosensitive ion channel; Region: MS_channel; pfam00924 324057019105 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 324057019106 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 324057019107 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 324057019108 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 324057019109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057019110 catalytic residue [active] 324057019111 ParB-like partition proteins; Region: parB_part; TIGR00180 324057019112 ParB-like nuclease domain; Region: ParBc; cl02129 324057019113 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324057019114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 324057019115 ParB-like partition proteins; Region: parB_part; TIGR00180 324057019116 ParB-like nuclease domain; Region: ParBc; cl02129 324057019117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 324057019118 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057019119 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 324057019120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057019121 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 324057019122 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 324057019123 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 324057019124 trmE is a tRNA modification GTPase; Region: trmE; cd04164 324057019125 G1 box; other site 324057019126 GTP/Mg2+ binding site [chemical binding]; other site 324057019127 Switch I region; other site 324057019128 G2 box; other site 324057019129 Switch II region; other site 324057019130 G3 box; other site 324057019131 G4 box; other site 324057019132 G5 box; other site 324057019133 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 324057019134 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 324057019135 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 324057019136 G-X-X-G motif; other site 324057019137 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 324057019138 RxxxH motif; other site 324057019139 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 324057019140 Ribonuclease P; Region: Ribonuclease_P; cl00457 324057019141 Ribosomal protein L34; Region: Ribosomal_L34; cl00370