-- dump date 20120504_154350 -- class Genbank::misc_feature -- table misc_feature_note -- id note 694427000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 694427000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 694427000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000004 Walker A motif; other site 694427000005 ATP binding site [chemical binding]; other site 694427000006 Walker B motif; other site 694427000007 arginine finger; other site 694427000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 694427000009 DnaA box-binding interface [nucleotide binding]; other site 694427000010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000011 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 694427000012 FAD binding domain; Region: FAD_binding_4; pfam01565 694427000013 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 694427000014 YceG-like family; Region: YceG; pfam02618 694427000015 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 694427000016 dimerization interface [polypeptide binding]; other site 694427000017 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427000018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 694427000020 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 694427000021 B12 binding site [chemical binding]; other site 694427000022 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 694427000023 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427000024 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427000025 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694427000026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000027 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427000028 Flavin Reductases; Region: FlaRed; cl00801 694427000029 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427000030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427000031 DNA binding residues [nucleotide binding] 694427000032 ferredoxin; Validated; Region: PRK07118 694427000033 4Fe-4S binding domain; Region: Fer4; cl02805 694427000034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000035 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 694427000036 Walker A/P-loop; other site 694427000037 ATP binding site [chemical binding]; other site 694427000038 Q-loop/lid; other site 694427000039 ABC transporter signature motif; other site 694427000040 Walker B; other site 694427000041 D-loop; other site 694427000042 H-loop/switch region; other site 694427000043 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427000044 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427000045 catalytic residues [active] 694427000046 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 694427000047 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 694427000048 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427000049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427000050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427000051 DNA binding residues [nucleotide binding] 694427000052 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694427000053 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 694427000054 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 694427000055 Helix-turn-helix domains; Region: HTH; cl00088 694427000056 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 694427000057 putative dimerization interface [polypeptide binding]; other site 694427000058 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 694427000059 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 694427000060 catalytic triad [active] 694427000061 Phospholipid methyltransferase; Region: PEMT; cl00763 694427000062 DAK2 domain; Region: Dak2; cl03685 694427000063 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 694427000064 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 694427000065 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427000066 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427000067 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427000068 catalytic residues [active] 694427000069 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 694427000070 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 694427000071 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 694427000072 active site 694427000073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427000074 metal binding site [ion binding]; metal-binding site 694427000075 Leucine carboxyl methyltransferase; Region: LCM; cl01306 694427000076 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 694427000077 Putative esterase; Region: Esterase; pfam00756 694427000078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427000079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427000080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427000081 dimer interface [polypeptide binding]; other site 694427000082 conserved gate region; other site 694427000083 putative PBP binding loops; other site 694427000084 ABC-ATPase subunit interface; other site 694427000085 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 694427000086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427000087 dimer interface [polypeptide binding]; other site 694427000088 conserved gate region; other site 694427000089 putative PBP binding loops; other site 694427000090 ABC-ATPase subunit interface; other site 694427000091 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 694427000092 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 694427000093 Walker A/P-loop; other site 694427000094 ATP binding site [chemical binding]; other site 694427000095 Q-loop/lid; other site 694427000096 ABC transporter signature motif; other site 694427000097 Walker B; other site 694427000098 D-loop; other site 694427000099 H-loop/switch region; other site 694427000100 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 694427000101 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000102 ATP binding site [chemical binding]; other site 694427000103 Mg++ binding site [ion binding]; other site 694427000104 motif III; other site 694427000105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000106 nucleotide binding region [chemical binding]; other site 694427000107 ATP-binding site [chemical binding]; other site 694427000108 chorismate binding enzyme; Region: Chorismate_bind; cl10555 694427000109 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 694427000110 2-isopropylmalate synthase; Validated; Region: PRK00915 694427000111 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 694427000112 active site 694427000113 catalytic residues [active] 694427000114 metal binding site [ion binding]; metal-binding site 694427000115 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 694427000116 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 694427000117 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 694427000118 substrate binding site [chemical binding]; other site 694427000119 ligand binding site [chemical binding]; other site 694427000120 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 694427000121 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 694427000122 substrate binding site [chemical binding]; other site 694427000123 (R)-citramalate synthase; Provisional; Region: PRK09389 694427000124 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 694427000125 active site 694427000126 catalytic residues [active] 694427000127 metal binding site [ion binding]; metal-binding site 694427000128 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 694427000129 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 694427000130 tartrate dehydrogenase; Provisional; Region: PRK08194 694427000131 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 694427000132 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 694427000133 catalytic residues [active] 694427000134 dimer interface [polypeptide binding]; other site 694427000135 Transcriptional regulators [Transcription]; Region: MarR; COG1846 694427000136 Helix-turn-helix domains; Region: HTH; cl00088 694427000137 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 694427000138 catalytic residues [active] 694427000139 dimer interface [polypeptide binding]; other site 694427000140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427000141 TPR motif; other site 694427000142 binding surface 694427000143 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 694427000144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694427000145 substrate binding site [chemical binding]; other site 694427000146 ATP binding site [chemical binding]; other site 694427000147 EamA-like transporter family; Region: EamA; cl01037 694427000148 EamA-like transporter family; Region: EamA; cl01037 694427000149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694427000150 putative acyl-acceptor binding pocket; other site 694427000151 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427000152 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 694427000153 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427000154 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 694427000155 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427000156 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427000157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 694427000158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000159 ATP binding site [chemical binding]; other site 694427000160 Mg2+ binding site [ion binding]; other site 694427000161 G-X-G motif; other site 694427000162 Response regulator receiver domain; Region: Response_reg; pfam00072 694427000163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427000164 active site 694427000165 phosphorylation site [posttranslational modification] 694427000166 intermolecular recognition site; other site 694427000167 dimerization interface [polypeptide binding]; other site 694427000168 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694427000169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000170 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000171 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427000172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427000173 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427000174 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427000175 active site 694427000176 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 694427000177 putative substrate binding site [chemical binding]; other site 694427000178 active site 694427000179 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 694427000180 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427000181 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 694427000182 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 694427000183 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427000184 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427000185 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427000186 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 694427000187 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 694427000188 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 694427000189 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694427000190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427000191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 694427000192 active site 694427000193 phosphorylation site [posttranslational modification] 694427000194 intermolecular recognition site; other site 694427000195 dimerization interface [polypeptide binding]; other site 694427000196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427000197 DNA binding site [nucleotide binding] 694427000198 TraB family; Region: TraB; cl12050 694427000199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427000200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 694427000201 Walker A/P-loop; other site 694427000202 ATP binding site [chemical binding]; other site 694427000203 Q-loop/lid; other site 694427000204 ABC transporter signature motif; other site 694427000205 Walker B; other site 694427000206 D-loop; other site 694427000207 H-loop/switch region; other site 694427000208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000209 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 694427000210 FtsX-like permease family; Region: FtsX; cl15850 694427000211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000212 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 694427000213 FtsX-like permease family; Region: FtsX; cl15850 694427000214 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427000215 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427000216 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427000217 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427000218 Helix-turn-helix domains; Region: HTH; cl00088 694427000219 phage shock protein C; Region: phageshock_pspC; TIGR02978 694427000220 PspC domain; Region: PspC; cl00864 694427000221 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 694427000222 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427000223 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427000224 glycine dehydrogenase; Provisional; Region: PRK05367 694427000225 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 694427000226 tetramer interface [polypeptide binding]; other site 694427000227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427000228 catalytic residue [active] 694427000229 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 694427000230 tetramer interface [polypeptide binding]; other site 694427000231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427000232 catalytic residue [active] 694427000233 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 694427000234 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 694427000235 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 694427000236 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 694427000237 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000238 ATP binding site [chemical binding]; other site 694427000239 Mg++ binding site [ion binding]; other site 694427000240 motif III; other site 694427000241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000242 nucleotide binding region [chemical binding]; other site 694427000243 ATP-binding site [chemical binding]; other site 694427000244 pyruvate phosphate dikinase; Provisional; Region: PRK09279 694427000245 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 694427000246 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 694427000247 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 694427000248 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 694427000249 Clp amino terminal domain; Region: Clp_N; pfam02861 694427000250 Clp amino terminal domain; Region: Clp_N; pfam02861 694427000251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000252 Walker A motif; other site 694427000253 ATP binding site [chemical binding]; other site 694427000254 Walker B motif; other site 694427000255 arginine finger; other site 694427000256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000257 Walker A motif; other site 694427000258 ATP binding site [chemical binding]; other site 694427000259 Walker B motif; other site 694427000260 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 694427000261 YceI-like domain; Region: YceI; cl01001 694427000262 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 694427000263 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694427000264 minor groove reading motif; other site 694427000265 helix-hairpin-helix signature motif; other site 694427000266 substrate binding pocket [chemical binding]; other site 694427000267 active site 694427000268 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 694427000269 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 694427000270 AP (apurinic/apyrimidinic) site pocket; other site 694427000271 DNA interaction; other site 694427000272 Metal-binding active site; metal-binding site 694427000273 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427000274 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427000275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 694427000276 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694427000277 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 694427000278 putative substrate binding site [chemical binding]; other site 694427000279 putative ATP binding site [chemical binding]; other site 694427000280 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694427000281 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427000282 DNA binding site [nucleotide binding] 694427000283 domain linker motif; other site 694427000284 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 694427000285 dimerization interface [polypeptide binding]; other site 694427000286 ligand binding site [chemical binding]; other site 694427000287 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 694427000288 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427000289 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 694427000290 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 694427000291 active site 694427000292 NTP binding site [chemical binding]; other site 694427000293 metal binding triad [ion binding]; metal-binding site 694427000294 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 694427000295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427000296 Zn2+ binding site [ion binding]; other site 694427000297 Mg2+ binding site [ion binding]; other site 694427000298 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 694427000299 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 694427000300 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427000301 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 694427000302 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 694427000303 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 694427000304 Rhomboid family; Region: Rhomboid; cl11446 694427000305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 694427000306 putative acyl-acceptor binding pocket; other site 694427000307 bile acid transporter; Region: bass; TIGR00841 694427000308 Membrane transport protein; Region: Mem_trans; cl09117 694427000309 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 694427000310 active site 694427000311 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 694427000312 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 694427000313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427000314 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 694427000315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 694427000316 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 694427000317 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 694427000318 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 694427000319 metal binding site [ion binding]; metal-binding site 694427000320 putative dimer interface [polypeptide binding]; other site 694427000321 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 694427000322 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427000323 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427000324 ABC transporter; Region: ABC_tran_2; pfam12848 694427000325 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427000326 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 694427000327 substrate binding pocket [chemical binding]; other site 694427000328 substrate-Mg2+ binding site; other site 694427000329 aspartate-rich region 1; other site 694427000330 aspartate-rich region 2; other site 694427000331 phytoene desaturase; Region: crtI_fam; TIGR02734 694427000332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000333 RDD family; Region: RDD; cl00746 694427000334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694427000335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000336 NAD(P) binding site [chemical binding]; other site 694427000337 active site 694427000338 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 694427000339 putative sugar binding site [chemical binding]; other site 694427000340 catalytic residues [active] 694427000341 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 694427000342 heme-binding site [chemical binding]; other site 694427000343 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 694427000344 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 694427000345 TPP-binding site; other site 694427000346 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694427000347 PYR/PP interface [polypeptide binding]; other site 694427000348 dimer interface [polypeptide binding]; other site 694427000349 TPP binding site [chemical binding]; other site 694427000350 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694427000351 Dehydratase family; Region: ILVD_EDD; cl00340 694427000352 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 694427000353 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 694427000354 PYR/PP interface [polypeptide binding]; other site 694427000355 dimer interface [polypeptide binding]; other site 694427000356 TPP binding site [chemical binding]; other site 694427000357 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 694427000358 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 694427000359 TPP-binding site [chemical binding]; other site 694427000360 dimer interface [polypeptide binding]; other site 694427000361 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 694427000362 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 694427000363 putative valine binding site [chemical binding]; other site 694427000364 dimer interface [polypeptide binding]; other site 694427000365 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 694427000366 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694427000367 active site 694427000368 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 694427000369 active site 2 [active] 694427000370 active site 1 [active] 694427000371 ketol-acid reductoisomerase; Validated; Region: PRK05225 694427000372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000373 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 694427000374 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 694427000375 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 694427000376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000377 Walker A motif; other site 694427000378 ATP binding site [chemical binding]; other site 694427000379 Walker B motif; other site 694427000380 arginine finger; other site 694427000381 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 694427000382 Septum formation initiator; Region: DivIC; cl11433 694427000383 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 694427000384 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 694427000385 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 694427000386 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 694427000387 Sporulation related domain; Region: SPOR; cl10051 694427000388 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 694427000389 MatE; Region: MatE; cl10513 694427000390 MatE; Region: MatE; cl10513 694427000391 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 694427000392 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 694427000393 putative active site [active] 694427000394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000395 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427000396 Glycogen synthase; Region: Glycogen_syn; pfam05693 694427000397 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 694427000398 putative homodimer interface [polypeptide binding]; other site 694427000399 putative active site pocket [active] 694427000400 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 694427000401 Protein of unknown function (DUF328); Region: DUF328; cl01143 694427000402 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 694427000403 active site 694427000404 ADP/pyrophosphate binding site [chemical binding]; other site 694427000405 dimerization interface [polypeptide binding]; other site 694427000406 allosteric effector site; other site 694427000407 fructose-1,6-bisphosphate binding site; other site 694427000408 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000409 DEAD-like helicases superfamily; Region: DEXDc; smart00487 694427000410 ATP binding site [chemical binding]; other site 694427000411 Mg++ binding site [ion binding]; other site 694427000412 motif III; other site 694427000413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000414 nucleotide binding region [chemical binding]; other site 694427000415 ATP-binding site [chemical binding]; other site 694427000416 DbpA RNA binding domain; Region: DbpA; pfam03880 694427000417 ethanolamine permease; Region: 2A0305; TIGR00908 694427000418 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 694427000419 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 694427000420 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 694427000421 alanine--tRNA ligase; Region: alaS; TIGR00344 694427000422 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 694427000423 Transglycosylase; Region: Transgly; cl07896 694427000424 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 694427000425 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 694427000426 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 694427000427 active site 694427000428 substrate binding site [chemical binding]; other site 694427000429 metal binding site [ion binding]; metal-binding site 694427000430 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 694427000431 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 694427000432 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 694427000433 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 694427000434 nucleotide binding site [chemical binding]; other site 694427000435 substrate binding site [chemical binding]; other site 694427000436 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 694427000437 dimer interface [polypeptide binding]; other site 694427000438 putative threonine allosteric regulatory site; other site 694427000439 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 694427000440 putative threonine allosteric regulatory site; other site 694427000441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000442 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 694427000443 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 694427000444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427000445 active site 694427000446 phosphorylation site [posttranslational modification] 694427000447 intermolecular recognition site; other site 694427000448 dimerization interface [polypeptide binding]; other site 694427000449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000450 Walker A motif; other site 694427000451 ATP binding site [chemical binding]; other site 694427000452 Walker B motif; other site 694427000453 arginine finger; other site 694427000454 Helix-turn-helix domains; Region: HTH; cl00088 694427000455 sensory histidine kinase AtoS; Provisional; Region: PRK11360 694427000456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000457 ATP binding site [chemical binding]; other site 694427000458 Mg2+ binding site [ion binding]; other site 694427000459 G-X-G motif; other site 694427000460 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427000461 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 694427000462 Walker A/P-loop; other site 694427000463 ATP binding site [chemical binding]; other site 694427000464 Q-loop/lid; other site 694427000465 ABC transporter signature motif; other site 694427000466 Walker B; other site 694427000467 D-loop; other site 694427000468 H-loop/switch region; other site 694427000469 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000470 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000471 FtsX-like permease family; Region: FtsX; cl15850 694427000472 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000473 FtsX-like permease family; Region: FtsX; cl15850 694427000474 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000475 FtsX-like permease family; Region: FtsX; cl15850 694427000476 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427000477 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427000478 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427000479 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 694427000480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000481 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427000482 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694427000483 RNA binding surface [nucleotide binding]; other site 694427000484 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 694427000485 active site 694427000486 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 694427000487 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 694427000488 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 694427000489 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427000490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 694427000491 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 694427000492 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427000493 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 694427000494 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 694427000495 active site 694427000496 nucleophile elbow; other site 694427000497 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 694427000498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 694427000499 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 694427000500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427000501 dimer interface [polypeptide binding]; other site 694427000502 phosphorylation site [posttranslational modification] 694427000503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000504 ATP binding site [chemical binding]; other site 694427000505 Mg2+ binding site [ion binding]; other site 694427000506 G-X-G motif; other site 694427000507 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 694427000508 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 694427000509 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 694427000510 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 694427000511 dimerization interface [polypeptide binding]; other site 694427000512 active site 694427000513 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 694427000514 dimer interface [polypeptide binding]; other site 694427000515 FMN binding site [chemical binding]; other site 694427000516 NADPH bind site [chemical binding]; other site 694427000517 glutamate dehydrogenase; Provisional; Region: PRK14030 694427000518 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 694427000519 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 694427000520 NAD(P) binding site [chemical binding]; other site 694427000521 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 694427000522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694427000523 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 694427000524 substrate binding pocket [chemical binding]; other site 694427000525 membrane-bound complex binding site; other site 694427000526 hinge residues; other site 694427000527 homoserine O-succinyltransferase; Provisional; Region: PRK05368 694427000528 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 694427000529 proposed active site lysine [active] 694427000530 conserved cys residue [active] 694427000531 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 694427000532 Peptidase family U32; Region: Peptidase_U32; cl03113 694427000533 Collagenase; Region: DUF3656; pfam12392 694427000534 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427000535 recombinase A; Provisional; Region: recA; PRK09354 694427000536 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 694427000537 hexamer interface [polypeptide binding]; other site 694427000538 Walker A motif; other site 694427000539 ATP binding site [chemical binding]; other site 694427000540 Walker B motif; other site 694427000541 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 694427000542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000543 Family description; Region: UvrD_C_2; cl15862 694427000544 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 694427000545 putative acyl-acceptor binding pocket; other site 694427000546 Predicted amidohydrolase [General function prediction only]; Region: COG0388 694427000547 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 694427000548 putative active site [active] 694427000549 catalytic triad [active] 694427000550 dimer interface [polypeptide binding]; other site 694427000551 multimer interface [polypeptide binding]; other site 694427000552 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 694427000553 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 694427000554 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 694427000555 iron binding site [ion binding]; other site 694427000556 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 694427000557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694427000558 minor groove reading motif; other site 694427000559 helix-hairpin-helix signature motif; other site 694427000560 substrate binding pocket [chemical binding]; other site 694427000561 active site 694427000562 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 694427000563 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 694427000564 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 694427000565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000566 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 694427000567 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 694427000568 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 694427000569 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 694427000570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427000571 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 694427000572 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694427000573 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694427000574 Ligand binding site; other site 694427000575 Putative Catalytic site; other site 694427000576 DXD motif; other site 694427000577 CrcB-like protein; Region: CRCB; cl09114 694427000578 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 694427000579 transketolase; Reviewed; Region: PRK05899 694427000580 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 694427000581 TPP-binding site [chemical binding]; other site 694427000582 dimer interface [polypeptide binding]; other site 694427000583 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694427000584 PYR/PP interface [polypeptide binding]; other site 694427000585 dimer interface [polypeptide binding]; other site 694427000586 TPP binding site [chemical binding]; other site 694427000587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694427000588 Domain of unknown function DUF; Region: DUF204; pfam02659 694427000589 Domain of unknown function DUF; Region: DUF204; pfam02659 694427000590 LrgA family; Region: LrgA; cl00608 694427000591 LrgB-like family; Region: LrgB; cl00596 694427000592 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 694427000593 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 694427000594 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 694427000595 structural tetrad; other site 694427000596 Phosphoesterase family; Region: Phosphoesterase; cl15450 694427000597 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 694427000598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427000599 motif II; other site 694427000600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427000601 non-specific DNA binding site [nucleotide binding]; other site 694427000602 salt bridge; other site 694427000603 sequence-specific DNA binding site [nucleotide binding]; other site 694427000604 Cupin domain; Region: Cupin_2; cl09118 694427000605 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 694427000606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694427000607 inhibitor-cofactor binding pocket; inhibition site 694427000608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427000609 catalytic residue [active] 694427000610 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 694427000611 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 694427000612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427000613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427000614 catalytic residue [active] 694427000615 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427000616 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000617 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427000618 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427000619 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427000620 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427000621 Sulfatase; Region: Sulfatase; cl10460 694427000622 Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078 694427000623 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 694427000624 nucleotide binding site [chemical binding]; other site 694427000625 substrate binding site [chemical binding]; other site 694427000626 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 694427000627 recombination factor protein RarA; Reviewed; Region: PRK13342 694427000628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000629 Walker A motif; other site 694427000630 ATP binding site [chemical binding]; other site 694427000631 Walker B motif; other site 694427000632 arginine finger; other site 694427000633 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 694427000634 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 694427000635 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427000636 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427000637 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 694427000638 Calx-beta domain; Region: Calx-beta; cl02522 694427000639 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 694427000640 active site 694427000641 catalytic residues [active] 694427000642 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427000643 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000644 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427000645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427000646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427000647 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427000648 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427000649 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427000650 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427000651 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427000652 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427000653 nudix motif; other site 694427000654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427000655 PQ loop repeat; Region: PQ-loop; cl12056 694427000656 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 694427000657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000658 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694427000659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000660 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 694427000661 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 694427000662 NADP binding site [chemical binding]; other site 694427000663 active site 694427000664 putative substrate binding site [chemical binding]; other site 694427000665 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 694427000666 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 694427000667 NADP-binding site; other site 694427000668 homotetramer interface [polypeptide binding]; other site 694427000669 substrate binding site [chemical binding]; other site 694427000670 homodimer interface [polypeptide binding]; other site 694427000671 active site 694427000672 tyrosine kinase; Provisional; Region: PRK11519 694427000673 Chain length determinant protein; Region: Wzz; cl15801 694427000674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000675 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427000676 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427000677 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427000678 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427000679 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427000680 catalytic residues [active] 694427000681 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 694427000682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694427000683 minor groove reading motif; other site 694427000684 helix-hairpin-helix signature motif; other site 694427000685 substrate binding pocket [chemical binding]; other site 694427000686 active site 694427000687 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 694427000688 DNA binding and oxoG recognition site [nucleotide binding] 694427000689 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694427000690 IHF - DNA interface [nucleotide binding]; other site 694427000691 IHF dimer interface [polypeptide binding]; other site 694427000692 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 694427000693 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 694427000694 homodimer interface [polypeptide binding]; other site 694427000695 oligonucleotide binding site [chemical binding]; other site 694427000696 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 694427000697 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 694427000698 RNA binding site [nucleotide binding]; other site 694427000699 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 694427000700 RNA binding site [nucleotide binding]; other site 694427000701 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 694427000702 RNA binding site [nucleotide binding]; other site 694427000703 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427000704 RNA binding site [nucleotide binding]; other site 694427000705 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427000706 RNA binding site [nucleotide binding]; other site 694427000707 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427000708 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 694427000709 active site 694427000710 catalytic triad [active] 694427000711 oxyanion hole [active] 694427000712 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427000713 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 694427000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000715 putative substrate translocation pore; other site 694427000716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000717 putative substrate translocation pore; other site 694427000718 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 694427000719 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427000720 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427000721 Helix-turn-helix domains; Region: HTH; cl00088 694427000722 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 694427000723 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 694427000724 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427000725 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 694427000726 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 694427000727 active site 694427000728 dimer interface [polypeptide binding]; other site 694427000729 motif 1; other site 694427000730 motif 2; other site 694427000731 motif 3; other site 694427000732 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 694427000733 anticodon binding site; other site 694427000734 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 694427000735 putative catalytic residue [active] 694427000736 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427000737 catalytic residues [active] 694427000738 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 694427000739 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 694427000740 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427000741 RNA binding surface [nucleotide binding]; other site 694427000742 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 694427000743 active site 694427000744 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 694427000745 TIGR01777 family protein; Region: yfcH 694427000746 putative NAD(P) binding site [chemical binding]; other site 694427000747 putative active site [active] 694427000748 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427000749 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000750 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427000751 LytTr DNA-binding domain; Region: LytTR; cl04498 694427000752 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 694427000753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427000754 S-adenosylmethionine binding site [chemical binding]; other site 694427000755 GGGtGRT protein; Region: GGGtGRT; pfam14057 694427000756 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427000757 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 694427000758 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 694427000759 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427000760 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427000761 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 694427000762 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 694427000763 metal binding site [ion binding]; metal-binding site 694427000764 dimer interface [polypeptide binding]; other site 694427000765 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 694427000766 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 694427000767 membrane ATPase/protein kinase; Provisional; Region: PRK09435 694427000768 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 694427000769 Walker A; other site 694427000770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000771 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 694427000772 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694427000773 dimer interface [polypeptide binding]; other site 694427000774 active site 694427000775 CoA binding pocket [chemical binding]; other site 694427000776 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 694427000777 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 694427000778 sensory histidine kinase AtoS; Provisional; Region: PRK11360 694427000779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000780 ATP binding site [chemical binding]; other site 694427000781 Mg2+ binding site [ion binding]; other site 694427000782 G-X-G motif; other site 694427000783 GTPase Era; Reviewed; Region: era; PRK00089 694427000784 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 694427000785 G1 box; other site 694427000786 GTP/Mg2+ binding site [chemical binding]; other site 694427000787 Switch I region; other site 694427000788 G2 box; other site 694427000789 Switch II region; other site 694427000790 G3 box; other site 694427000791 G4 box; other site 694427000792 G5 box; other site 694427000793 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 694427000794 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 694427000795 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 694427000796 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 694427000797 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427000798 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427000799 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 694427000800 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 694427000801 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 694427000802 Walker A/P-loop; other site 694427000803 ATP binding site [chemical binding]; other site 694427000804 Q-loop/lid; other site 694427000805 ABC transporter signature motif; other site 694427000806 Walker B; other site 694427000807 D-loop; other site 694427000808 H-loop/switch region; other site 694427000809 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 694427000810 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 694427000811 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427000812 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427000813 catalytic residue [active] 694427000814 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 694427000815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000816 NAD(P) binding site [chemical binding]; other site 694427000817 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 694427000818 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000819 ATP binding site [chemical binding]; other site 694427000820 Mg++ binding site [ion binding]; other site 694427000821 motif III; other site 694427000822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000823 nucleotide binding region [chemical binding]; other site 694427000824 ATP-binding site [chemical binding]; other site 694427000825 DbpA RNA binding domain; Region: DbpA; pfam03880 694427000826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000827 NADH(P)-binding; Region: NAD_binding_10; pfam13460 694427000828 NAD(P) binding site [chemical binding]; other site 694427000829 active site 694427000830 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 694427000831 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 694427000832 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 694427000833 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 694427000834 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 694427000835 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 694427000836 trimer interface [polypeptide binding]; other site 694427000837 active site 694427000838 substrate binding site [chemical binding]; other site 694427000839 CoA binding site [chemical binding]; other site 694427000840 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 694427000841 putative ligand binding site [chemical binding]; other site 694427000842 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 694427000843 Cation efflux family; Region: Cation_efflux; cl00316 694427000844 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 694427000845 Ligand binding site [chemical binding]; other site 694427000846 Electron transfer flavoprotein domain; Region: ETF; pfam01012 694427000847 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 694427000848 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 694427000849 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 694427000850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000851 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 694427000852 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 694427000853 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 694427000854 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 694427000855 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000856 ATP binding site [chemical binding]; other site 694427000857 Mg++ binding site [ion binding]; other site 694427000858 motif III; other site 694427000859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000860 nucleotide binding region [chemical binding]; other site 694427000861 ATP-binding site [chemical binding]; other site 694427000862 Cupin domain; Region: Cupin_2; cl09118 694427000863 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 694427000864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000865 Cupin domain; Region: Cupin_2; cl09118 694427000866 DoxX; Region: DoxX; cl00976 694427000867 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 694427000868 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 694427000869 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 694427000870 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 694427000871 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 694427000872 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 694427000873 Protein of unknown function (DUF423); Region: DUF423; cl01008 694427000874 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427000875 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 694427000876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000877 Walker A/P-loop; other site 694427000878 ATP binding site [chemical binding]; other site 694427000879 Q-loop/lid; other site 694427000880 ABC transporter signature motif; other site 694427000881 Walker B; other site 694427000882 D-loop; other site 694427000883 H-loop/switch region; other site 694427000884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427000885 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 694427000886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000887 Walker A/P-loop; other site 694427000888 ATP binding site [chemical binding]; other site 694427000889 Q-loop/lid; other site 694427000890 ABC transporter signature motif; other site 694427000891 Walker B; other site 694427000892 D-loop; other site 694427000893 H-loop/switch region; other site 694427000894 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 694427000895 dimer interface [polypeptide binding]; other site 694427000896 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 694427000897 putative hydrophobic ligand binding site [chemical binding]; other site 694427000898 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 694427000899 dimer interface [polypeptide binding]; other site 694427000900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427000901 Helix-turn-helix domains; Region: HTH; cl00088 694427000902 short chain dehydrogenase; Provisional; Region: PRK06523 694427000903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000904 NAD(P) binding site [chemical binding]; other site 694427000905 active site 694427000906 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 694427000907 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 694427000908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 694427000909 intermolecular recognition site; other site 694427000910 active site 694427000911 dimerization interface [polypeptide binding]; other site 694427000912 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 694427000913 Probable beta-xylosidase; Provisional; Region: PLN03080 694427000914 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427000915 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427000916 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427000917 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 694427000918 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427000919 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 694427000920 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 694427000921 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 694427000922 NlpC/P60 family; Region: NLPC_P60; cl11438 694427000923 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 694427000924 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427000925 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 694427000926 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427000927 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427000928 catalytic residues [active] 694427000929 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 694427000930 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000931 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427000932 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 694427000933 Helix-turn-helix domains; Region: HTH; cl00088 694427000934 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427000935 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 694427000936 NADH dehydrogenase subunit B; Provisional; Region: PRK14816 694427000937 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 694427000938 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 694427000939 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 694427000940 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 694427000941 NADH dehydrogenase; Region: NADHdh; cl00469 694427000942 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 694427000943 4Fe-4S binding domain; Region: Fer4; cl02805 694427000944 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 694427000945 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 694427000946 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 694427000947 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 694427000948 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 694427000949 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 694427000950 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 694427000951 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 694427000952 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 694427000953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 694427000954 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 694427000955 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694427000956 putative active site [active] 694427000957 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 694427000958 Protein of unknown function (DUF454); Region: DUF454; cl01063 694427000959 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 694427000960 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 694427000961 Sensory domain found in PocR; Region: PocR; pfam10114 694427000962 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 694427000963 PAS fold; Region: PAS; pfam00989 694427000964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427000965 putative active site [active] 694427000966 heme pocket [chemical binding]; other site 694427000967 PAS fold; Region: PAS_3; pfam08447 694427000968 hypothetical protein; Provisional; Region: PRK13560 694427000969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427000970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427000971 Histidine kinase; Region: HisKA_3; pfam07730 694427000972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000973 ATP binding site [chemical binding]; other site 694427000974 Mg2+ binding site [ion binding]; other site 694427000975 G-X-G motif; other site 694427000976 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 694427000977 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 694427000978 dimer interface [polypeptide binding]; other site 694427000979 PYR/PP interface [polypeptide binding]; other site 694427000980 TPP binding site [chemical binding]; other site 694427000981 substrate binding site [chemical binding]; other site 694427000982 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 694427000983 Domain of unknown function; Region: EKR; cl11037 694427000984 4Fe-4S binding domain; Region: Fer4; cl02805 694427000985 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427000986 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 694427000987 TPP-binding site [chemical binding]; other site 694427000988 dimer interface [polypeptide binding]; other site 694427000989 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427000990 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 694427000991 Helix-turn-helix domains; Region: HTH; cl00088 694427000992 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 694427000993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427000994 Beta-Casp domain; Region: Beta-Casp; cl12567 694427000995 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 694427000996 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 694427000997 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427000998 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427000999 putative peptidoglycan binding site; other site 694427001000 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 694427001001 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 694427001002 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427001003 putative peptidoglycan binding site; other site 694427001004 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 694427001005 ligand binding site [chemical binding]; other site 694427001006 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427001007 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 694427001008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427001009 S-adenosylmethionine binding site [chemical binding]; other site 694427001010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001011 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 694427001012 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 694427001013 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 694427001014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427001015 nucleotide binding region [chemical binding]; other site 694427001016 ATP-binding site [chemical binding]; other site 694427001017 SEC-C motif; Region: SEC-C; pfam02810 694427001018 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 694427001019 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 694427001020 NAD(P) binding site [chemical binding]; other site 694427001021 homotetramer interface [polypeptide binding]; other site 694427001022 homodimer interface [polypeptide binding]; other site 694427001023 active site 694427001024 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 694427001025 transcription termination factor Rho; Provisional; Region: rho; PRK09376 694427001026 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 694427001027 RNA binding site [nucleotide binding]; other site 694427001028 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 694427001029 multimer interface [polypeptide binding]; other site 694427001030 Walker A motif; other site 694427001031 ATP binding site [chemical binding]; other site 694427001032 Walker B motif; other site 694427001033 Cytochrome c; Region: Cytochrom_C; cl11414 694427001034 MgtC family; Region: MgtC; pfam02308 694427001035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427001036 Helix-turn-helix domains; Region: HTH; cl00088 694427001037 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427001038 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427001039 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427001040 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427001041 Protein export membrane protein; Region: SecD_SecF; cl14618 694427001042 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427001043 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 694427001044 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694427001045 carboxyltransferase (CT) interaction site; other site 694427001046 biotinylation site [posttranslational modification]; other site 694427001047 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 694427001048 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 694427001049 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 694427001050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427001051 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 694427001052 dimer interface [polypeptide binding]; other site 694427001053 substrate binding site [chemical binding]; other site 694427001054 metal binding site [ion binding]; metal-binding site 694427001055 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 694427001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427001057 Predicted transcriptional regulator [Transcription]; Region: COG2932 694427001058 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 694427001059 Catalytic site [active] 694427001060 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 694427001061 transcriptional activator RfaH; Region: RfaH; TIGR01955 694427001062 polysaccharide export protein Wza; Provisional; Region: PRK15078 694427001063 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427001064 SLBB domain; Region: SLBB; pfam10531 694427001065 Chain length determinant protein; Region: Wzz; cl15801 694427001066 tyrosine kinase; Provisional; Region: PRK11519 694427001067 Chain length determinant protein; Region: Wzz; cl15801 694427001068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001069 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 694427001070 trimer interface [polypeptide binding]; other site 694427001071 active site 694427001072 substrate binding site [chemical binding]; other site 694427001073 CoA binding site [chemical binding]; other site 694427001074 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 694427001075 Rhamnan synthesis protein F; Region: RgpF; cl01529 694427001076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427001077 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427001078 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 694427001079 FMN binding site [chemical binding]; other site 694427001080 dimer interface [polypeptide binding]; other site 694427001081 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 694427001082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427001083 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 694427001084 putative ADP-binding pocket [chemical binding]; other site 694427001085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427001086 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 694427001087 Probable Catalytic site; other site 694427001088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427001089 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 694427001090 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 694427001091 substrate binding site; other site 694427001092 tetramer interface; other site 694427001093 Cupin domain; Region: Cupin_2; cl09118 694427001094 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 694427001095 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 694427001096 NADP binding site [chemical binding]; other site 694427001097 active site 694427001098 putative substrate binding site [chemical binding]; other site 694427001099 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 694427001100 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 694427001101 NAD binding site [chemical binding]; other site 694427001102 substrate binding site [chemical binding]; other site 694427001103 homodimer interface [polypeptide binding]; other site 694427001104 active site 694427001105 putative acyl transferase; Provisional; Region: PRK10502 694427001106 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 694427001107 active site 694427001108 substrate binding site [chemical binding]; other site 694427001109 trimer interface [polypeptide binding]; other site 694427001110 CoA binding site [chemical binding]; other site 694427001111 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 694427001112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001113 Bacterial sugar transferase; Region: Bac_transf; cl00939 694427001114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427001115 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 694427001116 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427001117 putative active site [active] 694427001118 putative metal binding site [ion binding]; other site 694427001119 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 694427001120 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 694427001121 trmE is a tRNA modification GTPase; Region: trmE; cd04164 694427001122 G1 box; other site 694427001123 GTP/Mg2+ binding site [chemical binding]; other site 694427001124 Switch I region; other site 694427001125 G2 box; other site 694427001126 Switch II region; other site 694427001127 G3 box; other site 694427001128 G4 box; other site 694427001129 G5 box; other site 694427001130 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 694427001131 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 694427001132 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 694427001133 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 694427001134 catalytic center binding site [active] 694427001135 ATP binding site [chemical binding]; other site 694427001136 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 694427001137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427001138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427001139 DNA binding residues [nucleotide binding] 694427001140 lipoyl synthase; Provisional; Region: PRK05481 694427001141 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427001142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427001143 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427001144 FOG: PKD repeat [General function prediction only]; Region: COG3291 694427001145 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427001146 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 694427001147 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 694427001148 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427001149 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427001150 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427001151 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 694427001152 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 694427001153 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 694427001154 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 694427001155 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427001156 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001157 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427001158 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427001159 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427001160 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427001161 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427001162 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427001163 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001164 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427001165 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427001166 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427001167 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 694427001168 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427001169 substrate binding site [chemical binding]; other site 694427001170 active site 694427001171 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 694427001172 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 694427001173 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 694427001174 mannonate dehydratase; Provisional; Region: PRK03906 694427001175 mannonate dehydratase; Region: uxuA; TIGR00695 694427001176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 694427001178 NAD(P) binding site [chemical binding]; other site 694427001179 active site 694427001180 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 694427001181 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427001182 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 694427001183 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001184 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427001185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427001186 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 694427001187 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 694427001188 Histidine kinase; Region: His_kinase; pfam06580 694427001189 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427001190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427001191 active site 694427001192 phosphorylation site [posttranslational modification] 694427001193 intermolecular recognition site; other site 694427001194 dimerization interface [polypeptide binding]; other site 694427001195 LytTr DNA-binding domain; Region: LytTR; cl04498 694427001196 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 694427001197 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 694427001198 HEPN domain; Region: HEPN; cl00824 694427001199 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427001200 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 694427001201 hydrophobic ligand binding site; other site 694427001202 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427001203 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427001204 N-terminal plug; other site 694427001205 ligand-binding site [chemical binding]; other site 694427001206 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 694427001207 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 694427001208 Uncharacterized conserved protein [Function unknown]; Region: COG1284 694427001209 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 694427001210 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427001211 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001212 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427001213 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427001214 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 694427001215 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 694427001216 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 694427001217 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 694427001218 FOG: PKD repeat [General function prediction only]; Region: COG3291 694427001219 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427001220 Uncharacterized conserved protein [Function unknown]; Region: COG3391 694427001221 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 694427001222 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 694427001223 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 694427001224 proposed catalytic triad [active] 694427001225 active site nucleophile [active] 694427001226 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 694427001227 isoaspartyl dipeptidase; Provisional; Region: PRK10657 694427001228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427001229 active site 694427001230 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 694427001231 active site 694427001232 Zn binding site [ion binding]; other site 694427001233 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 694427001234 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 694427001235 active site 694427001236 octamer interface [polypeptide binding]; other site 694427001237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427001238 L-lysine aminotransferase; Provisional; Region: PRK08297 694427001239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427001240 catalytic residue [active] 694427001241 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 694427001242 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 694427001243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001244 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 694427001245 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 694427001246 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 694427001247 Flavin Reductases; Region: FlaRed; cl00801 694427001248 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 694427001249 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 694427001250 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 694427001251 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 694427001252 dimer interface [polypeptide binding]; other site 694427001253 active site 694427001254 glycine-pyridoxal phosphate binding site [chemical binding]; other site 694427001255 folate binding site [chemical binding]; other site 694427001256 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427001257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001258 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 694427001259 ATP binding site [chemical binding]; other site 694427001260 active site 694427001261 substrate binding site [chemical binding]; other site 694427001262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427001263 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 694427001264 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 694427001265 intersubunit interface [polypeptide binding]; other site 694427001266 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001267 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427001268 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427001269 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694427001270 metal-binding site [ion binding] 694427001271 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 694427001272 intersubunit interface [polypeptide binding]; other site 694427001273 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001274 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 694427001275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427001276 N-terminal plug; other site 694427001277 ligand-binding site [chemical binding]; other site 694427001278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001279 excinuclease ABC, A subunit; Region: uvra; TIGR00630 694427001280 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 694427001281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001282 Walker A/P-loop; other site 694427001283 ATP binding site [chemical binding]; other site 694427001284 Q-loop/lid; other site 694427001285 ABC transporter signature motif; other site 694427001286 Walker B; other site 694427001287 D-loop; other site 694427001288 H-loop/switch region; other site 694427001289 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 694427001290 homodimer interaction site [polypeptide binding]; other site 694427001291 cofactor binding site; other site 694427001292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694427001293 ABC-ATPase subunit interface; other site 694427001294 dimer interface [polypeptide binding]; other site 694427001295 putative PBP binding regions; other site 694427001296 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 694427001297 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694427001298 Walker A/P-loop; other site 694427001299 ATP binding site [chemical binding]; other site 694427001300 Q-loop/lid; other site 694427001301 ABC transporter signature motif; other site 694427001302 Walker B; other site 694427001303 D-loop; other site 694427001304 H-loop/switch region; other site 694427001305 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001306 AAA domain; Region: AAA_23; pfam13476 694427001307 Walker A/P-loop; other site 694427001308 ATP binding site [chemical binding]; other site 694427001309 PAS domain S-box; Region: sensory_box; TIGR00229 694427001310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427001311 putative active site [active] 694427001312 heme pocket [chemical binding]; other site 694427001313 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 694427001314 active site 694427001315 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 694427001316 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 694427001317 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 694427001318 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 694427001319 catalytic site [active] 694427001320 subunit interface [polypeptide binding]; other site 694427001321 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 694427001322 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694427001323 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427001324 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 694427001325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694427001326 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427001327 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 694427001328 probable substrate binding site [chemical binding]; other site 694427001329 K+ potassium transporter; Region: K_trans; cl15781 694427001330 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 694427001331 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 694427001332 G1 box; other site 694427001333 putative GEF interaction site [polypeptide binding]; other site 694427001334 GTP/Mg2+ binding site [chemical binding]; other site 694427001335 Switch I region; other site 694427001336 G2 box; other site 694427001337 G3 box; other site 694427001338 Switch II region; other site 694427001339 G4 box; other site 694427001340 G5 box; other site 694427001341 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 694427001342 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427001343 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 694427001344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001345 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 694427001346 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 694427001347 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 694427001348 TPP-binding site [chemical binding]; other site 694427001349 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 694427001350 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 694427001351 dimer interface [polypeptide binding]; other site 694427001352 PYR/PP interface [polypeptide binding]; other site 694427001353 TPP binding site [chemical binding]; other site 694427001354 substrate binding site [chemical binding]; other site 694427001355 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694427001356 Ferredoxin [Energy production and conversion]; Region: COG1146 694427001357 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427001358 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 694427001359 putative active site [active] 694427001360 putative metal binding residues [ion binding]; other site 694427001361 signature motif; other site 694427001362 putative dimer interface [polypeptide binding]; other site 694427001363 putative phosphate binding site [ion binding]; other site 694427001364 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 694427001365 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 694427001366 Protein of unknown function (DUF554); Region: DUF554; cl00784 694427001367 Peptidase family M48; Region: Peptidase_M48; cl12018 694427001368 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 694427001369 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 694427001370 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 694427001371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694427001372 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 694427001373 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427001374 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 694427001375 pyruvate carboxylase subunit B; Validated; Region: PRK09282 694427001376 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694427001377 carboxyltransferase (CT) interaction site; other site 694427001378 biotinylation site [posttranslational modification]; other site 694427001379 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427001380 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427001381 active site 694427001382 metal binding site [ion binding]; metal-binding site 694427001383 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 694427001384 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 694427001385 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427001386 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427001387 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 694427001388 active site 694427001389 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427001390 dimer interface [polypeptide binding]; other site 694427001391 substrate binding site [chemical binding]; other site 694427001392 catalytic residues [active] 694427001393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694427001394 Ligand Binding Site [chemical binding]; other site 694427001395 Ion channel; Region: Ion_trans_2; cl11596 694427001396 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 694427001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001398 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 694427001399 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 694427001400 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427001401 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427001402 DNA binding site [nucleotide binding] 694427001403 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 694427001404 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 694427001405 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 694427001406 active site 694427001407 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 694427001408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001409 FeS/SAM binding site; other site 694427001410 Maf-like protein; Region: Maf; pfam02545 694427001411 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 694427001412 active site 694427001413 dimer interface [polypeptide binding]; other site 694427001414 UbiA prenyltransferase family; Region: UbiA; cl00337 694427001415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001416 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 694427001417 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427001418 FMN binding site [chemical binding]; other site 694427001419 dimer interface [polypeptide binding]; other site 694427001420 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 694427001421 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 694427001422 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427001423 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427001424 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427001425 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 694427001426 GSCFA family; Region: GSCFA; pfam08885 694427001427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427001428 D-galactonate transporter; Region: 2A0114; TIGR00893 694427001429 putative substrate translocation pore; other site 694427001430 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 694427001431 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 694427001432 active site 694427001433 intersubunit interface [polypeptide binding]; other site 694427001434 catalytic residue [active] 694427001435 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694427001436 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 694427001437 substrate binding site [chemical binding]; other site 694427001438 ATP binding site [chemical binding]; other site 694427001439 Glucuronate isomerase; Region: UxaC; cl00829 694427001440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427001441 DNA binding site [nucleotide binding] 694427001442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427001443 DNA binding site [nucleotide binding] 694427001444 domain linker motif; other site 694427001445 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 694427001446 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 694427001447 ligand binding site [chemical binding]; other site 694427001448 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 694427001449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001450 NAD(P) binding site [chemical binding]; other site 694427001451 active site 694427001452 mannonate dehydratase; Provisional; Region: PRK03906 694427001453 mannonate dehydratase; Region: uxuA; TIGR00695 694427001454 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 694427001455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001456 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 694427001457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001458 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 694427001459 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 694427001460 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 694427001461 LytTr DNA-binding domain; Region: LytTR; cl04498 694427001462 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001463 HerA helicase [Replication, recombination, and repair]; Region: COG0433 694427001464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 694427001465 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427001466 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427001467 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427001468 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 694427001469 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 694427001470 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427001471 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427001472 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 694427001473 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427001474 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 694427001475 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 694427001476 putative deacylase active site [active] 694427001477 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427001478 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 694427001479 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 694427001480 tetramer interface [polypeptide binding]; other site 694427001481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427001482 catalytic residue [active] 694427001483 Protein of unknown function (DUF3276); Region: DUF3276; cl15305 694427001484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427001485 active site 694427001486 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 694427001487 Preprotein translocase subunit; Region: YajC; cl00806 694427001488 YbbR-like protein; Region: YbbR; pfam07949 694427001489 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 694427001490 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427001491 inhibitor-cofactor binding pocket; inhibition site 694427001492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427001493 catalytic residue [active] 694427001494 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 694427001495 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 694427001496 putative trimer interface [polypeptide binding]; other site 694427001497 putative active site [active] 694427001498 putative substrate binding site [chemical binding]; other site 694427001499 putative CoA binding site [chemical binding]; other site 694427001500 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 694427001501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001502 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 694427001503 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 694427001504 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 694427001505 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 694427001506 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 694427001507 TraB family; Region: TraB; cl12050 694427001508 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 694427001509 Helix-turn-helix domains; Region: HTH; cl00088 694427001510 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 694427001511 dimerization interface [polypeptide binding]; other site 694427001512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001513 TPR motif; other site 694427001514 binding surface 694427001515 TPR repeat; Region: TPR_11; pfam13414 694427001516 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427001517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001518 binding surface 694427001519 TPR motif; other site 694427001520 TPR repeat; Region: TPR_11; pfam13414 694427001521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001522 binding surface 694427001523 TPR motif; other site 694427001524 Tetratricopeptide repeat; Region: TPR_9; pfam13371 694427001525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001526 binding surface 694427001527 TPR motif; other site 694427001528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001529 binding surface 694427001530 TPR motif; other site 694427001531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001532 TPR motif; other site 694427001533 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427001534 binding surface 694427001535 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 694427001536 Transglycosylase; Region: Transgly; cl07896 694427001537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427001538 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 694427001539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001540 FeS/SAM binding site; other site 694427001541 HemN C-terminal domain; Region: HemN_C; pfam06969 694427001542 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 694427001543 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427001544 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 694427001545 putative acyl-acceptor binding pocket; other site 694427001546 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 694427001547 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 694427001548 Probable Catalytic site; other site 694427001549 metal-binding site 694427001550 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 694427001551 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 694427001552 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 694427001553 active site 694427001554 dimer interface [polypeptide binding]; other site 694427001555 effector binding site; other site 694427001556 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 694427001557 TSCPD domain; Region: TSCPD; cl14834 694427001558 recombination protein F; Reviewed; Region: recF; PRK00064 694427001559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001560 Walker A/P-loop; other site 694427001561 ATP binding site [chemical binding]; other site 694427001562 Q-loop/lid; other site 694427001563 ABC transporter signature motif; other site 694427001564 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001565 ABC transporter signature motif; other site 694427001566 Walker B; other site 694427001567 D-loop; other site 694427001568 H-loop/switch region; other site 694427001569 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 694427001570 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 694427001571 Malic enzyme, N-terminal domain; Region: malic; pfam00390 694427001572 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 694427001573 putative NAD(P) binding site [chemical binding]; other site 694427001574 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 694427001575 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 694427001576 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 694427001577 peptidase T; Region: peptidase-T; TIGR01882 694427001578 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 694427001579 metal binding site [ion binding]; metal-binding site 694427001580 dimer interface [polypeptide binding]; other site 694427001581 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 694427001582 putative active site [active] 694427001583 hypothetical protein; Provisional; Region: PRK00955 694427001584 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 694427001585 B12 binding site [chemical binding]; other site 694427001586 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 694427001587 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 694427001588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001589 FeS/SAM binding site; other site 694427001590 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 694427001591 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 694427001592 catalytic residues [active] 694427001593 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 694427001594 putative active cleft [active] 694427001595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427001596 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694427001597 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694427001598 Ligand binding site; other site 694427001599 Putative Catalytic site; other site 694427001600 DXD motif; other site 694427001601 GtrA-like protein; Region: GtrA; cl00971 694427001602 AAA domain; Region: AAA_22; pfam13401 694427001603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001604 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 694427001605 Family description; Region: UvrD_C_2; cl15862 694427001606 HRDC domain; Region: HRDC; cl02578 694427001607 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427001608 DoxX; Region: DoxX; cl00976 694427001609 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 694427001610 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 694427001611 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 694427001612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001613 FeS/SAM binding site; other site 694427001614 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 694427001615 FMN reductase; Validated; Region: fre; PRK08051 694427001616 FAD binding pocket [chemical binding]; other site 694427001617 conserved FAD binding motif [chemical binding]; other site 694427001618 phosphate binding motif [ion binding]; other site 694427001619 beta-alpha-beta structure motif; other site 694427001620 NAD binding pocket [chemical binding]; other site 694427001621 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 694427001622 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 694427001623 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 694427001624 Ligand Binding Site [chemical binding]; other site 694427001625 B3/4 domain; Region: B3_4; cl11458 694427001626 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 694427001627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427001628 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 694427001629 active site 694427001630 catalytic residues [active] 694427001631 metal binding site [ion binding]; metal-binding site 694427001632 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 694427001633 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 694427001634 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 694427001635 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 694427001636 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427001637 catalytic residue [active] 694427001638 Peptidase family M48; Region: Peptidase_M48; cl12018 694427001639 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 694427001640 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 694427001641 Active site serine [active] 694427001642 CAAX protease self-immunity; Region: Abi; cl00558 694427001643 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427001644 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 694427001645 Walker A/P-loop; other site 694427001646 ATP binding site [chemical binding]; other site 694427001647 Q-loop/lid; other site 694427001648 ABC transporter signature motif; other site 694427001649 Walker B; other site 694427001650 D-loop; other site 694427001651 H-loop/switch region; other site 694427001652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427001653 Coenzyme A binding pocket [chemical binding]; other site 694427001654 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427001655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001657 Family description; Region: UvrD_C_2; cl15862 694427001658 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 694427001659 putative active site [active] 694427001660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427001661 DNA binding residues [nucleotide binding] 694427001662 dimerization interface [polypeptide binding]; other site 694427001663 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 694427001664 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427001665 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427001666 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 694427001667 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427001668 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427001669 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427001670 active site 694427001671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427001672 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 694427001673 active site 694427001674 catalytic triad [active] 694427001675 oxyanion hole [active] 694427001676 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427001677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694427001678 putative acyl-acceptor binding pocket; other site 694427001679 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 694427001680 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 694427001681 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 694427001682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427001683 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 694427001684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427001685 catalytic residue [active] 694427001686 hypothetical protein; Provisional; Region: PRK11820 694427001687 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 694427001688 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 694427001689 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 694427001690 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 694427001691 catalytic site [active] 694427001692 G-X2-G-X-G-K; other site 694427001693 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 694427001694 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 694427001695 active site 694427001696 (T/H)XGH motif; other site 694427001697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 694427001699 Acyl transferase domain; Region: Acyl_transf_1; cl08282 694427001700 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 694427001701 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 694427001702 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 694427001703 dimer interface [polypeptide binding]; other site 694427001704 anticodon binding site; other site 694427001705 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 694427001706 homodimer interface [polypeptide binding]; other site 694427001707 motif 1; other site 694427001708 active site 694427001709 motif 2; other site 694427001710 GAD domain; Region: GAD; pfam02938 694427001711 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 694427001712 motif 3; other site 694427001713 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 694427001714 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 694427001715 PhnA protein; Region: PhnA; pfam03831 694427001716 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 694427001717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427001718 Coenzyme A binding pocket [chemical binding]; other site 694427001719 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427001720 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 694427001721 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 694427001722 RNA/DNA binding site [nucleotide binding]; other site 694427001723 RRM dimerization site [polypeptide binding]; other site 694427001724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427001725 putative substrate translocation pore; other site 694427001726 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 694427001727 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 694427001728 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 694427001729 N- and C-terminal domain interface [polypeptide binding]; other site 694427001730 active site 694427001731 MgATP binding site [chemical binding]; other site 694427001732 catalytic site [active] 694427001733 metal binding site [ion binding]; metal-binding site 694427001734 carbohydrate binding site [chemical binding]; other site 694427001735 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427001736 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 694427001737 active site 694427001738 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 694427001739 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 694427001740 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 694427001741 uracil transporter; Provisional; Region: PRK10720 694427001742 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 694427001743 EamA-like transporter family; Region: EamA; cl01037 694427001744 EamA-like transporter family; Region: EamA; cl01037 694427001745 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 694427001746 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 694427001747 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427001748 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427001749 prolyl-tRNA synthetase; Provisional; Region: PRK08661 694427001750 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 694427001751 dimer interface [polypeptide binding]; other site 694427001752 motif 1; other site 694427001753 active site 694427001754 motif 2; other site 694427001755 motif 3; other site 694427001756 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 694427001757 anticodon binding site; other site 694427001758 zinc-binding site [ion binding]; other site 694427001759 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 694427001760 putative active site [active] 694427001761 putative metal binding site [ion binding]; other site 694427001762 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 694427001763 Bacterial SH3 domain; Region: SH3_3; cl02551 694427001764 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427001765 CAAX protease self-immunity; Region: Abi; cl00558 694427001766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427001767 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427001768 CUB-like domain; Region: CUB_2; pfam02408 694427001769 Predicted esterase [General function prediction only]; Region: COG0400 694427001770 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427001771 CUB-like domain; Region: CUB_2; pfam02408 694427001772 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 694427001773 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 694427001774 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 694427001775 active site 694427001776 DJ-1 family protein; Region: not_thiJ; TIGR01383 694427001777 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 694427001778 conserved cys residue [active] 694427001779 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 694427001780 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 694427001781 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 694427001782 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 694427001783 RNA binding site [nucleotide binding]; other site 694427001784 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 694427001785 DNA polymerase III, delta subunit; Region: holA; TIGR01128 694427001786 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 694427001787 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 694427001788 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 694427001789 A new structural DNA glycosylase; Region: AlkD_like; cd06561 694427001790 active site 694427001791 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 694427001792 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 694427001793 putative active site [active] 694427001794 putative metal binding site [ion binding]; other site 694427001795 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 694427001796 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 694427001797 heterodimer interface [polypeptide binding]; other site 694427001798 active site 694427001799 FMN binding site [chemical binding]; other site 694427001800 homodimer interface [polypeptide binding]; other site 694427001801 substrate binding site [chemical binding]; other site 694427001802 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 694427001803 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 694427001804 FAD binding pocket [chemical binding]; other site 694427001805 FAD binding motif [chemical binding]; other site 694427001806 phosphate binding motif [ion binding]; other site 694427001807 beta-alpha-beta structure motif; other site 694427001808 NAD binding pocket [chemical binding]; other site 694427001809 Iron coordination center [ion binding]; other site 694427001810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427001811 non-specific DNA binding site [nucleotide binding]; other site 694427001812 salt bridge; other site 694427001813 sequence-specific DNA binding site [nucleotide binding]; other site 694427001814 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 694427001815 Putative zinc ribbon domain; Region: DUF164; pfam02591 694427001816 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 694427001817 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 694427001818 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 694427001819 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 694427001820 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 694427001821 catalytic residues [active] 694427001822 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 694427001823 active site 694427001824 putative substrate binding region [chemical binding]; other site 694427001825 Protein of unknown function (DUF419); Region: DUF419; cl15265 694427001826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001827 ABC transporter signature motif; other site 694427001828 Walker B; other site 694427001829 D-loop; other site 694427001830 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427001831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001832 Walker A/P-loop; other site 694427001833 ATP binding site [chemical binding]; other site 694427001834 Q-loop/lid; other site 694427001835 ABC transporter signature motif; other site 694427001836 Walker B; other site 694427001837 D-loop; other site 694427001838 H-loop/switch region; other site 694427001839 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 694427001840 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694427001841 active site 694427001842 catalytic residues [active] 694427001843 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 694427001844 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427001845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427001846 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 694427001847 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 694427001848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 694427001849 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 694427001850 catalytic triad [active] 694427001851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001852 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694427001853 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 694427001854 dimer interface [polypeptide binding]; other site 694427001855 substrate binding site [chemical binding]; other site 694427001856 metal binding sites [ion binding]; metal-binding site 694427001857 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 694427001858 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694427001859 FMN binding site [chemical binding]; other site 694427001860 active site 694427001861 catalytic residues [active] 694427001862 substrate binding site [chemical binding]; other site 694427001863 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 694427001864 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 694427001865 active site residue [active] 694427001866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001867 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 694427001868 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 694427001869 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 694427001870 dimerization interface [polypeptide binding]; other site 694427001871 ATP binding site [chemical binding]; other site 694427001872 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 694427001873 dimerization interface [polypeptide binding]; other site 694427001874 ATP binding site [chemical binding]; other site 694427001875 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 694427001876 putative active site [active] 694427001877 catalytic triad [active] 694427001878 Helix-turn-helix domains; Region: HTH; cl00088 694427001879 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 694427001880 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 694427001881 NADP binding site [chemical binding]; other site 694427001882 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 694427001883 Helix-turn-helix domains; Region: HTH; cl00088 694427001884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 694427001885 dimerization interface [polypeptide binding]; other site 694427001886 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 694427001887 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427001888 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 694427001889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001890 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 694427001891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 694427001892 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427001893 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427001894 N-terminal plug; other site 694427001895 ligand-binding site [chemical binding]; other site 694427001896 peptide chain release factor 1; Validated; Region: prfA; PRK00591 694427001897 RF-1 domain; Region: RF-1; cl02875 694427001898 RF-1 domain; Region: RF-1; cl02875 694427001899 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 694427001900 active site 694427001901 dimer interface [polypeptide binding]; other site 694427001902 Probable dihydrodipicolinate reductase; Region: PLN02775 694427001903 Cupin domain; Region: Cupin_2; cl09118 694427001904 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 694427001905 active site 694427001906 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 694427001907 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 694427001908 hybrid cluster protein; Provisional; Region: PRK05290 694427001909 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427001910 ACS interaction site; other site 694427001911 CODH interaction site; other site 694427001912 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 694427001913 hybrid metal cluster; other site 694427001914 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 694427001915 4Fe-4S binding domain; Region: Fer4; cl02805 694427001916 Cupin domain; Region: Cupin_2; cl09118 694427001917 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427001918 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427001919 ligand binding site [chemical binding]; other site 694427001920 flexible hinge region; other site 694427001921 Helix-turn-helix domains; Region: HTH; cl00088 694427001922 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 694427001923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427001924 N-terminal plug; other site 694427001925 ligand-binding site [chemical binding]; other site 694427001926 Uncharacterized conserved protein [Function unknown]; Region: COG3391 694427001927 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 694427001928 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 694427001929 homodimer interface [polypeptide binding]; other site 694427001930 Walker A motif; other site 694427001931 ATP binding site [chemical binding]; other site 694427001932 hydroxycobalamin binding site [chemical binding]; other site 694427001933 Walker B motif; other site 694427001934 cobyric acid synthase; Provisional; Region: PRK00784 694427001935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427001936 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 694427001937 catalytic triad [active] 694427001938 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 694427001939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427001940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427001941 homodimer interface [polypeptide binding]; other site 694427001942 catalytic residue [active] 694427001943 CobD/Cbib protein; Region: CobD_Cbib; cl00561 694427001944 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 694427001945 putative ligand binding site [chemical binding]; other site 694427001946 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 694427001947 homotrimer interface [polypeptide binding]; other site 694427001948 Walker A motif; other site 694427001949 GTP binding site [chemical binding]; other site 694427001950 Walker B motif; other site 694427001951 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 694427001952 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 694427001953 active site pocket [active] 694427001954 putative dimer interface [polypeptide binding]; other site 694427001955 putative cataytic base [active] 694427001956 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 694427001957 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694427001958 catalytic core [active] 694427001959 Cupin domain; Region: Cupin_2; cl09118 694427001960 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 694427001961 active site 694427001962 amidophosphoribosyltransferase; Provisional; Region: PRK06388 694427001963 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 694427001964 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 694427001965 glutaminase active site [active] 694427001966 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 694427001967 dimer interface [polypeptide binding]; other site 694427001968 active site 694427001969 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 694427001970 dimer interface [polypeptide binding]; other site 694427001971 active site 694427001972 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 694427001973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427001974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427001975 homodimer interface [polypeptide binding]; other site 694427001976 catalytic residue [active] 694427001977 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 694427001978 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 694427001979 NADP binding site [chemical binding]; other site 694427001980 dimer interface [polypeptide binding]; other site 694427001981 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 694427001982 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427001983 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 694427001984 MatE; Region: MatE; cl10513 694427001985 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 694427001986 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 694427001987 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 694427001988 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 694427001989 MgtE intracellular N domain; Region: MgtE_N; cl15244 694427001990 FOG: CBS domain [General function prediction only]; Region: COG0517 694427001991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 694427001992 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 694427001993 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 694427001994 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 694427001995 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 694427001996 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 694427001997 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 694427001998 homopentamer interface [polypeptide binding]; other site 694427001999 active site 694427002000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002001 TPR motif; other site 694427002002 binding surface 694427002003 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 694427002004 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 694427002005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427002006 ATP binding site [chemical binding]; other site 694427002007 putative Mg++ binding site [ion binding]; other site 694427002008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427002009 nucleotide binding region [chemical binding]; other site 694427002010 ATP-binding site [chemical binding]; other site 694427002011 TRCF domain; Region: TRCF; cl04088 694427002012 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 694427002013 nucleoside/Zn binding site; other site 694427002014 dimer interface [polypeptide binding]; other site 694427002015 catalytic motif [active] 694427002016 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002017 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002018 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002019 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002020 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427002021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002022 binding surface 694427002023 TPR motif; other site 694427002024 DNA gyrase subunit A; Validated; Region: PRK05560 694427002025 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 694427002026 CAP-like domain; other site 694427002027 active site 694427002028 primary dimer interface [polypeptide binding]; other site 694427002029 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002030 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002035 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 694427002036 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694427002037 replicative DNA helicase; Region: DnaB; TIGR00665 694427002038 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 694427002039 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 694427002040 Walker A motif; other site 694427002041 ATP binding site [chemical binding]; other site 694427002042 Walker B motif; other site 694427002043 DNA binding loops [nucleotide binding] 694427002044 nucleoside transporter; Region: 2A0110; TIGR00889 694427002045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002046 putative substrate translocation pore; other site 694427002047 Bifunctional nuclease; Region: DNase-RNase; cl00553 694427002048 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 694427002049 SmpB-tmRNA interface; other site 694427002050 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 694427002051 AMP-binding enzyme; Region: AMP-binding; cl15778 694427002052 Predicted methyltransferases [General function prediction only]; Region: COG0313 694427002053 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 694427002054 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427002055 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427002056 ABC transporter; Region: ABC_tran_2; pfam12848 694427002057 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427002058 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 694427002059 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 694427002060 Mg++ binding site [ion binding]; other site 694427002061 putative catalytic motif [active] 694427002062 substrate binding site [chemical binding]; other site 694427002063 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 694427002064 oligomerization interface [polypeptide binding]; other site 694427002065 active site 694427002066 metal binding site [ion binding]; metal-binding site 694427002067 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427002068 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427002069 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427002070 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427002071 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427002072 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002073 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002074 Transcriptional regulator; Region: Transcrip_reg; cl00361 694427002075 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 694427002076 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 694427002077 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 694427002078 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002079 ligand binding site [chemical binding]; other site 694427002080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002081 Family description; Region: UvrD_C_2; cl15862 694427002082 FkbH-like domain; Region: FkbH; TIGR01686 694427002083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427002084 active site 694427002085 motif I; other site 694427002086 motif II; other site 694427002087 Predicted membrane protein [Function unknown]; Region: COG2364 694427002088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 694427002089 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 694427002090 Peptidase family M49; Region: Peptidase_M49; pfam03571 694427002091 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 694427002092 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 694427002093 active site 694427002094 dimer interfaces [polypeptide binding]; other site 694427002095 catalytic residues [active] 694427002096 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 694427002097 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 694427002098 active site 694427002099 Zn binding site [ion binding]; other site 694427002100 pullulanase, type I; Region: pulA_typeI; TIGR02104 694427002101 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 694427002102 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 694427002103 Ca binding site [ion binding]; other site 694427002104 active site 694427002105 catalytic site [active] 694427002106 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 694427002107 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 694427002108 CoA-binding site [chemical binding]; other site 694427002109 Clp protease ATP binding subunit; Region: clpC; CHL00095 694427002110 Clp amino terminal domain; Region: Clp_N; pfam02861 694427002111 Clp amino terminal domain; Region: Clp_N; pfam02861 694427002112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427002113 Walker A motif; other site 694427002114 ATP binding site [chemical binding]; other site 694427002115 Walker B motif; other site 694427002116 YtzH-like protein; Region: YtzH; pfam14165 694427002117 arginine finger; other site 694427002118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427002119 Walker A motif; other site 694427002120 ATP binding site [chemical binding]; other site 694427002121 Walker B motif; other site 694427002122 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 694427002123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 694427002124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002125 putative substrate translocation pore; other site 694427002126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002127 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 694427002128 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 694427002129 active site 694427002130 substrate binding site [chemical binding]; other site 694427002131 metal binding site [ion binding]; metal-binding site 694427002132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002133 Walker A/P-loop; other site 694427002134 ATP binding site [chemical binding]; other site 694427002135 ABC transporter; Region: ABC_tran; pfam00005 694427002136 Q-loop/lid; other site 694427002137 ABC transporter signature motif; other site 694427002138 Walker B; other site 694427002139 D-loop; other site 694427002140 H-loop/switch region; other site 694427002141 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 694427002142 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 694427002143 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 694427002144 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 694427002145 dimer interface [polypeptide binding]; other site 694427002146 active site 694427002147 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 694427002148 folate binding site [chemical binding]; other site 694427002149 NADP+ binding site [chemical binding]; other site 694427002150 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 694427002151 dimerization interface [polypeptide binding]; other site 694427002152 active site 694427002153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002154 binding surface 694427002155 TPR motif; other site 694427002156 translocation protein TolB; Provisional; Region: tolB; PRK02889 694427002157 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427002158 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002159 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002160 ligand binding site [chemical binding]; other site 694427002161 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 694427002162 translocation protein TolB; Provisional; Region: tolB; PRK02889 694427002163 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 694427002164 ResB-like family; Region: ResB; pfam05140 694427002165 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 694427002166 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 694427002167 Ferredoxin [Energy production and conversion]; Region: COG1146 694427002168 4Fe-4S binding domain; Region: Fer4; cl02805 694427002169 4Fe-4S binding domain; Region: Fer4; cl02805 694427002170 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 694427002171 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 694427002172 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 694427002173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427002174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427002175 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 694427002176 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 694427002177 Preprotein binding site; other site 694427002178 SecA binding site; other site 694427002179 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427002180 Helix-turn-helix domains; Region: HTH; cl00088 694427002181 Helix-turn-helix domains; Region: HTH; cl00088 694427002182 Outer membrane efflux protein; Region: OEP; pfam02321 694427002183 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427002184 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 694427002185 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427002186 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427002187 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 694427002188 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 694427002189 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427002190 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 694427002191 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427002192 Protein of unknown function (DUF805); Region: DUF805; cl01224 694427002193 excinuclease ABC subunit B; Provisional; Region: PRK05298 694427002194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427002195 ATP binding site [chemical binding]; other site 694427002196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427002197 nucleotide binding region [chemical binding]; other site 694427002198 ATP-binding site [chemical binding]; other site 694427002199 Ultra-violet resistance protein B; Region: UvrB; pfam12344 694427002200 PspC domain; Region: PspC; cl00864 694427002201 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 694427002202 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 694427002203 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427002204 Zn2+ binding site [ion binding]; other site 694427002205 Mg2+ binding site [ion binding]; other site 694427002206 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 694427002207 4-alpha-glucanotransferase; Region: PLN02950 694427002208 starch-binding site 2 [chemical binding]; other site 694427002209 starch-binding site 1 [chemical binding]; other site 694427002210 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 694427002211 starch-binding site 2 [chemical binding]; other site 694427002212 starch-binding site 1 [chemical binding]; other site 694427002213 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 694427002214 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 694427002215 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 694427002216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427002217 active site 694427002218 amino acid transporter; Region: 2A0306; TIGR00909 694427002219 Spore germination protein; Region: Spore_permease; cl15802 694427002220 Spore germination protein; Region: Spore_permease; cl15802 694427002221 amino acid transporter; Region: 2A0306; TIGR00909 694427002222 Spore germination protein; Region: Spore_permease; cl15802 694427002223 Spore germination protein; Region: Spore_permease; cl15802 694427002224 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 694427002225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 694427002226 active site 694427002227 ATP binding site [chemical binding]; other site 694427002228 substrate binding site [chemical binding]; other site 694427002229 activation loop (A-loop); other site 694427002230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427002231 Putative esterase; Region: Esterase; pfam00756 694427002232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427002233 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 694427002234 active site 694427002235 catalytic triad [active] 694427002236 dimer interface [polypeptide binding]; other site 694427002237 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 694427002238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002239 NAD(P) binding site [chemical binding]; other site 694427002240 active site 694427002241 Cyclophilin-like; Region: Cyclophil_like; cl00950 694427002242 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 694427002243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427002244 Coenzyme A binding pocket [chemical binding]; other site 694427002245 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 694427002246 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 694427002247 trimer interface [polypeptide binding]; other site 694427002248 active site 694427002249 substrate binding site [chemical binding]; other site 694427002250 CoA binding site [chemical binding]; other site 694427002251 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427002252 active site 694427002253 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 694427002254 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 694427002255 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 694427002256 active site 694427002257 metal binding site [ion binding]; metal-binding site 694427002258 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694427002259 E3 interaction surface; other site 694427002260 lipoyl attachment site [posttranslational modification]; other site 694427002261 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 694427002262 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427002263 active site 694427002264 catalytic site [active] 694427002265 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 694427002266 dimer interface [polypeptide binding]; other site 694427002267 catalytic triad [active] 694427002268 peroxidatic and resolving cysteines [active] 694427002269 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 694427002270 active site 694427002271 catalytic site [active] 694427002272 substrate binding site [chemical binding]; other site 694427002273 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 694427002274 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 694427002275 FMN binding site [chemical binding]; other site 694427002276 substrate binding site [chemical binding]; other site 694427002277 putative catalytic residue [active] 694427002278 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 694427002279 putative ligand binding site [chemical binding]; other site 694427002280 YceI-like domain; Region: YceI; cl01001 694427002281 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 694427002282 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 694427002283 active site 694427002284 catalytic residues [active] 694427002285 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 694427002286 DNA-binding site [nucleotide binding]; DNA binding site 694427002287 RNA-binding motif; other site 694427002288 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 694427002289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002290 ATP binding site [chemical binding]; other site 694427002291 putative Mg++ binding site [ion binding]; other site 694427002292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427002293 nucleotide binding region [chemical binding]; other site 694427002294 ATP-binding site [chemical binding]; other site 694427002295 DbpA RNA binding domain; Region: DbpA; pfam03880 694427002296 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 694427002297 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 694427002298 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 694427002299 hinge; other site 694427002300 active site 694427002301 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427002302 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 694427002303 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 694427002304 Walker A/P-loop; other site 694427002305 ATP binding site [chemical binding]; other site 694427002306 Q-loop/lid; other site 694427002307 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 694427002308 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 694427002309 ABC transporter signature motif; other site 694427002310 Walker B; other site 694427002311 D-loop; other site 694427002312 H-loop/switch region; other site 694427002313 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 694427002314 Flavoprotein; Region: Flavoprotein; cl08021 694427002315 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 694427002316 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 694427002317 ApbE family; Region: ApbE; cl00643 694427002318 dihydroorotase; Reviewed; Region: PRK09236 694427002319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427002320 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 694427002321 active site 694427002322 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 694427002323 Ligand binding site; other site 694427002324 Putative Catalytic site; other site 694427002325 DXD motif; other site 694427002326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427002327 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 694427002328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002329 TPR motif; other site 694427002330 binding surface 694427002331 AsmA-like C-terminal region; Region: AsmA_2; cl15864 694427002332 ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926 694427002333 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 694427002334 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 694427002335 Cation efflux family; Region: Cation_efflux; cl00316 694427002336 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 694427002337 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 694427002338 Ligand Binding Site [chemical binding]; other site 694427002339 TIGR00269 family protein; Region: TIGR00269 694427002340 Protein of unknown function, DUF486; Region: DUF486; cl01236 694427002341 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 694427002342 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 694427002343 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427002344 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427002345 ABC transporter; Region: ABC_tran_2; pfam12848 694427002346 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427002347 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 694427002348 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 694427002349 NAD(P) binding site [chemical binding]; other site 694427002350 homodimer interface [polypeptide binding]; other site 694427002351 substrate binding site [chemical binding]; other site 694427002352 active site 694427002353 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 694427002354 Kelch motif; Region: Kelch_1; cl02701 694427002355 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 694427002356 Kelch motif; Region: Kelch_1; cl02701 694427002357 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 694427002358 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427002359 inhibitor-cofactor binding pocket; inhibition site 694427002360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002361 catalytic residue [active] 694427002362 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427002363 active site 694427002364 metal binding site [ion binding]; metal-binding site 694427002365 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694427002366 extended (e) SDRs; Region: SDR_e; cd08946 694427002367 NAD(P) binding site [chemical binding]; other site 694427002368 active site 694427002369 substrate binding site [chemical binding]; other site 694427002370 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 694427002371 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 694427002372 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427002373 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 694427002374 WbqC-like protein family; Region: WbqC; pfam08889 694427002375 Bacterial sugar transferase; Region: Bac_transf; cl00939 694427002376 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 694427002377 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 694427002378 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 694427002379 active site 694427002380 homodimer interface [polypeptide binding]; other site 694427002381 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 694427002382 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 694427002383 putative NAD(P) binding site [chemical binding]; other site 694427002384 active site 694427002385 putative substrate binding site [chemical binding]; other site 694427002386 Cupin domain; Region: Cupin_2; cl09118 694427002387 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 694427002388 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 694427002389 NAD(P) binding site [chemical binding]; other site 694427002390 homodimer interface [polypeptide binding]; other site 694427002391 substrate binding site [chemical binding]; other site 694427002392 active site 694427002393 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 694427002394 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427002395 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 694427002396 Rhamnan synthesis protein F; Region: RgpF; cl01529 694427002397 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002399 active site 694427002400 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427002401 MatE; Region: MatE; cl10513 694427002402 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427002403 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694427002404 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 694427002405 NAD binding site [chemical binding]; other site 694427002406 homotetramer interface [polypeptide binding]; other site 694427002407 homodimer interface [polypeptide binding]; other site 694427002408 active site 694427002409 substrate binding site [chemical binding]; other site 694427002410 extended (e) SDRs; Region: SDR_e; cd08946 694427002411 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 694427002412 NAD(P) binding site [chemical binding]; other site 694427002413 active site 694427002414 substrate binding site [chemical binding]; other site 694427002415 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 694427002416 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 694427002417 NAD binding site [chemical binding]; other site 694427002418 homotetramer interface [polypeptide binding]; other site 694427002419 homodimer interface [polypeptide binding]; other site 694427002420 substrate binding site [chemical binding]; other site 694427002421 active site 694427002422 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 694427002423 substrate binding site; other site 694427002424 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 694427002425 FAD binding pocket [chemical binding]; other site 694427002426 conserved FAD binding motif [chemical binding]; other site 694427002427 phosphate binding motif [ion binding]; other site 694427002428 beta-alpha-beta structure motif; other site 694427002429 NAD binding pocket [chemical binding]; other site 694427002430 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 694427002431 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427002432 inhibitor-cofactor binding pocket; inhibition site 694427002433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002434 catalytic residue [active] 694427002435 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 694427002436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002437 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694427002438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002439 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427002440 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427002441 SLBB domain; Region: SLBB; pfam10531 694427002442 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427002443 SLBB domain; Region: SLBB; pfam10531 694427002444 SLBB domain; Region: SLBB; pfam10531 694427002445 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427002446 SLBB domain; Region: SLBB; pfam10531 694427002447 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 694427002448 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 694427002449 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 694427002450 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 694427002451 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694427002452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002453 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 694427002454 nudix motif; other site 694427002455 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694427002456 carboxyltransferase (CT) interaction site; other site 694427002457 biotinylation site [posttranslational modification]; other site 694427002458 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 694427002459 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 694427002460 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 694427002461 Protein of unknown function (DUF721); Region: DUF721; cl02324 694427002462 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 694427002463 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 694427002464 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427002465 putative peptidoglycan binding site; other site 694427002466 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 694427002467 active site 694427002468 catalytic motif [active] 694427002469 Zn binding site [ion binding]; other site 694427002470 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 694427002471 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694427002472 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 694427002473 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 694427002474 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 694427002475 dimerization interface [polypeptide binding]; other site 694427002476 active site 694427002477 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 694427002478 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 694427002479 putative NAD(P) binding site [chemical binding]; other site 694427002480 homodimer interface [polypeptide binding]; other site 694427002481 homotetramer interface [polypeptide binding]; other site 694427002482 active site 694427002483 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002484 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002485 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002486 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002487 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002488 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002489 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002490 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002491 chaperone protein DnaJ; Provisional; Region: PRK14289 694427002492 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694427002493 HSP70 interaction site [polypeptide binding]; other site 694427002494 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 694427002495 substrate binding site [polypeptide binding]; other site 694427002496 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 694427002497 Zn binding sites [ion binding]; other site 694427002498 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 694427002499 dimer interface [polypeptide binding]; other site 694427002500 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 694427002501 dimer interface [polypeptide binding]; other site 694427002502 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 694427002503 Motility related/secretion protein; Region: SprA_N; pfam14349 694427002504 Motility related/secretion protein; Region: SprA_N; pfam14349 694427002505 Motility related/secretion protein; Region: SprA_N; pfam14349 694427002506 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 694427002507 RuvA N terminal domain; Region: RuvA_N; pfam01330 694427002508 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 694427002509 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 694427002510 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 694427002511 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 694427002512 Proline dehydrogenase; Region: Pro_dh; cl03282 694427002513 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 694427002514 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 694427002515 Glutamate binding site [chemical binding]; other site 694427002516 NAD binding site [chemical binding]; other site 694427002517 catalytic residues [active] 694427002518 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 694427002519 OsmC-like protein; Region: OsmC; cl00767 694427002520 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 694427002521 active site clefts [active] 694427002522 zinc binding site [ion binding]; other site 694427002523 dimer interface [polypeptide binding]; other site 694427002524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002525 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 694427002526 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 694427002527 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 694427002528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002529 Walker A/P-loop; other site 694427002530 ATP binding site [chemical binding]; other site 694427002531 Q-loop/lid; other site 694427002532 ABC transporter signature motif; other site 694427002533 Walker B; other site 694427002534 D-loop; other site 694427002535 H-loop/switch region; other site 694427002536 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 694427002537 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427002538 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002539 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427002540 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427002541 catalytic residues [active] 694427002542 FixH; Region: FixH; cl01254 694427002543 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002544 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 694427002545 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 694427002546 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 694427002547 Outer membrane efflux protein; Region: OEP; pfam02321 694427002548 Outer membrane efflux protein; Region: OEP; pfam02321 694427002549 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427002550 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427002551 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427002552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427002553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427002554 H+ Antiporter protein; Region: 2A0121; TIGR00900 694427002555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002556 putative substrate translocation pore; other site 694427002557 Helix-turn-helix domains; Region: HTH; cl00088 694427002558 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 694427002559 Sulfatase; Region: Sulfatase; cl10460 694427002560 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 694427002561 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 694427002562 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 694427002563 heterodimer interface [polypeptide binding]; other site 694427002564 substrate interaction site [chemical binding]; other site 694427002565 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 694427002566 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 694427002567 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 694427002568 active site 694427002569 substrate binding site [chemical binding]; other site 694427002570 coenzyme B12 binding site [chemical binding]; other site 694427002571 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 694427002572 B12 binding site [chemical binding]; other site 694427002573 cobalt ligand [ion binding]; other site 694427002574 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002575 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002576 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 694427002577 MG2 domain; Region: A2M_N; pfam01835 694427002578 Cation efflux family; Region: Cation_efflux; cl00316 694427002579 PAS domain S-box; Region: sensory_box; TIGR00229 694427002580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427002581 putative active site [active] 694427002582 heme pocket [chemical binding]; other site 694427002583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427002584 PAS fold; Region: PAS_3; pfam08447 694427002585 putative active site [active] 694427002586 heme pocket [chemical binding]; other site 694427002587 PAS domain S-box; Region: sensory_box; TIGR00229 694427002588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427002589 putative active site [active] 694427002590 heme pocket [chemical binding]; other site 694427002591 Histidine kinase; Region: HisKA_3; pfam07730 694427002592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427002593 ATP binding site [chemical binding]; other site 694427002594 Mg2+ binding site [ion binding]; other site 694427002595 G-X-G motif; other site 694427002596 Pirin-related protein [General function prediction only]; Region: COG1741 694427002597 Cupin domain; Region: Cupin_2; cl09118 694427002598 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 694427002599 Predicted membrane protein [Function unknown]; Region: COG2311 694427002600 Protein of unknown function (DUF418); Region: DUF418; cl12135 694427002601 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 694427002602 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 694427002603 substrate binding site [chemical binding]; other site 694427002604 ligand binding site [chemical binding]; other site 694427002605 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 694427002606 substrate binding site [chemical binding]; other site 694427002607 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 694427002608 dimer interface [polypeptide binding]; other site 694427002609 Citrate synthase; Region: Citrate_synt; pfam00285 694427002610 active site 694427002611 citrylCoA binding site [chemical binding]; other site 694427002612 oxalacetate/citrate binding site [chemical binding]; other site 694427002613 coenzyme A binding site [chemical binding]; other site 694427002614 catalytic triad [active] 694427002615 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427002616 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 694427002617 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 694427002618 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 694427002619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427002620 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 694427002621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427002622 DNA binding residues [nucleotide binding] 694427002623 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 694427002624 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 694427002625 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 694427002626 protein binding site [polypeptide binding]; other site 694427002627 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 694427002628 protein binding site [polypeptide binding]; other site 694427002629 enolase; Provisional; Region: eno; PRK00077 694427002630 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 694427002631 dimer interface [polypeptide binding]; other site 694427002632 metal binding site [ion binding]; metal-binding site 694427002633 substrate binding pocket [chemical binding]; other site 694427002634 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 694427002635 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 694427002636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002637 Walker A/P-loop; other site 694427002638 ATP binding site [chemical binding]; other site 694427002639 Q-loop/lid; other site 694427002640 ABC transporter signature motif; other site 694427002641 Walker B; other site 694427002642 D-loop; other site 694427002643 H-loop/switch region; other site 694427002644 Plant ATP synthase F0; Region: YMF19; cl07975 694427002645 Smr domain; Region: Smr; cl02619 694427002646 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 694427002647 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 694427002648 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 694427002649 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 694427002650 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 694427002651 Walker A/P-loop; other site 694427002652 ATP binding site [chemical binding]; other site 694427002653 Q-loop/lid; other site 694427002654 ABC transporter signature motif; other site 694427002655 Walker B; other site 694427002656 D-loop; other site 694427002657 H-loop/switch region; other site 694427002658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 694427002659 DNA-binding site [nucleotide binding]; DNA binding site 694427002660 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 694427002661 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 694427002662 catalytic triad [active] 694427002663 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 694427002664 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427002665 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 694427002666 dihydrodipicolinate synthase; Region: dapA; TIGR00674 694427002667 dimer interface [polypeptide binding]; other site 694427002668 active site 694427002669 catalytic residue [active] 694427002670 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 694427002671 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 694427002672 nucleotide binding pocket [chemical binding]; other site 694427002673 K-X-D-G motif; other site 694427002674 catalytic site [active] 694427002675 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 694427002676 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 694427002677 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 694427002678 Dimer interface [polypeptide binding]; other site 694427002679 BRCT sequence motif; other site 694427002680 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 694427002681 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427002682 FtsX-like permease family; Region: FtsX; cl15850 694427002683 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427002684 aspartate aminotransferase; Provisional; Region: PRK07568 694427002685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427002686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002687 homodimer interface [polypeptide binding]; other site 694427002688 catalytic residue [active] 694427002689 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002690 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427002691 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 694427002692 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694427002693 Walker A/P-loop; other site 694427002694 ATP binding site [chemical binding]; other site 694427002695 Q-loop/lid; other site 694427002696 ABC transporter signature motif; other site 694427002697 Walker B; other site 694427002698 D-loop; other site 694427002699 H-loop/switch region; other site 694427002700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694427002701 ABC-ATPase subunit interface; other site 694427002702 dimer interface [polypeptide binding]; other site 694427002703 putative PBP binding regions; other site 694427002704 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 694427002705 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 694427002706 putative ligand binding site [chemical binding]; other site 694427002707 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 694427002708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002709 Predicted GTPase [General function prediction only]; Region: COG0218 694427002710 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 694427002711 G1 box; other site 694427002712 GTP/Mg2+ binding site [chemical binding]; other site 694427002713 Switch I region; other site 694427002714 G2 box; other site 694427002715 G3 box; other site 694427002716 Switch II region; other site 694427002717 G4 box; other site 694427002718 G5 box; other site 694427002719 Sodium:solute symporter family; Region: SSF; cl00456 694427002720 recombination protein RecR; Reviewed; Region: recR; PRK00076 694427002721 RecR protein; Region: RecR; pfam02132 694427002722 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 694427002723 putative active site [active] 694427002724 putative metal-binding site [ion binding]; other site 694427002725 tetramer interface [polypeptide binding]; other site 694427002726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427002727 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427002728 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 694427002729 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 694427002730 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 694427002731 UDP-glucose 4-epimerase; Region: PLN02240 694427002732 NAD binding site [chemical binding]; other site 694427002733 homodimer interface [polypeptide binding]; other site 694427002734 active site 694427002735 substrate binding site [chemical binding]; other site 694427002736 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427002737 active site 694427002738 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002739 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002740 ligand binding site [chemical binding]; other site 694427002741 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427002742 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427002743 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 694427002744 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427002745 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 694427002746 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002747 ligand binding site [chemical binding]; other site 694427002748 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 694427002749 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 694427002750 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 694427002751 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 694427002752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427002753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002754 homodimer interface [polypeptide binding]; other site 694427002755 catalytic residue [active] 694427002756 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002757 Nitrogen regulatory protein P-II; Region: P-II; cl00412 694427002758 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427002759 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 694427002760 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 694427002761 Nitrogen regulatory protein P-II; Region: P-II; cl00412 694427002762 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427002763 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 694427002764 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 694427002765 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 694427002766 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 694427002767 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 694427002768 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 694427002769 active site 694427002770 dimer interface [polypeptide binding]; other site 694427002771 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 694427002772 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 694427002773 active site 694427002774 FMN binding site [chemical binding]; other site 694427002775 substrate binding site [chemical binding]; other site 694427002776 3Fe-4S cluster binding site [ion binding]; other site 694427002777 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 694427002778 domain interface; other site 694427002779 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 694427002780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002781 asparagine synthetase B; Provisional; Region: asnB; PRK09431 694427002782 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 694427002783 active site 694427002784 dimer interface [polypeptide binding]; other site 694427002785 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 694427002786 Ligand Binding Site [chemical binding]; other site 694427002787 Molecular Tunnel; other site 694427002788 AAA domain; Region: AAA_28; pfam13521 694427002789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002790 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427002791 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427002792 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 694427002793 active site 694427002794 metal-binding site [ion binding] 694427002795 nucleotide-binding site [chemical binding]; other site 694427002796 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427002797 Catalytic site [active] 694427002798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427002799 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 694427002800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427002801 Walker A/P-loop; other site 694427002802 ATP binding site [chemical binding]; other site 694427002803 Q-loop/lid; other site 694427002804 ABC transporter signature motif; other site 694427002805 Walker B; other site 694427002806 D-loop; other site 694427002807 H-loop/switch region; other site 694427002808 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 694427002809 Bacterial sugar transferase; Region: Bac_transf; cl00939 694427002810 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 694427002811 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 694427002812 active site 694427002813 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 694427002814 homodimer interface [polypeptide binding]; other site 694427002815 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 694427002816 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 694427002817 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 694427002818 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 694427002819 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427002820 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427002821 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 694427002822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427002823 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427002824 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002825 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002826 active site 694427002827 LytTr DNA-binding domain; Region: LytTR; cl04498 694427002828 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 694427002829 OpgC protein; Region: OpgC_C; cl00792 694427002830 Acyltransferase family; Region: Acyl_transf_3; pfam01757 694427002831 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002833 active site 694427002834 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 694427002835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002836 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427002837 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 694427002838 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 694427002839 putative active site [active] 694427002840 putative metal binding site [ion binding]; other site 694427002841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427002842 active site 694427002843 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 694427002844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002845 active site 694427002846 Rhamnan synthesis protein F; Region: RgpF; cl01529 694427002847 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002848 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 694427002849 metal-binding site 694427002850 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002852 active site 694427002853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427002854 S-adenosylmethionine binding site [chemical binding]; other site 694427002855 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 694427002856 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 694427002857 Walker A/P-loop; other site 694427002858 ATP binding site [chemical binding]; other site 694427002859 Q-loop/lid; other site 694427002860 ABC transporter signature motif; other site 694427002861 Walker B; other site 694427002862 D-loop; other site 694427002863 H-loop/switch region; other site 694427002864 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 694427002865 putative carbohydrate binding site [chemical binding]; other site 694427002866 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427002867 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 694427002868 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427002869 inhibitor-cofactor binding pocket; inhibition site 694427002870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002871 catalytic residue [active] 694427002872 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 694427002873 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694427002874 dimer interface [polypeptide binding]; other site 694427002875 active site 694427002876 CoA binding pocket [chemical binding]; other site 694427002877 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 694427002878 classical (c) SDRs; Region: SDR_c; cd05233 694427002879 NAD(P) binding site [chemical binding]; other site 694427002880 active site 694427002881 Phosphopantetheine attachment site; Region: PP-binding; cl09936 694427002882 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 694427002883 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 694427002884 putative trimer interface [polypeptide binding]; other site 694427002885 putative CoA binding site [chemical binding]; other site 694427002886 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694427002887 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694427002888 Ligand binding site; other site 694427002889 Putative Catalytic site; other site 694427002890 DXD motif; other site 694427002891 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 694427002892 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427002893 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427002894 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 694427002895 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694427002896 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 694427002897 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 694427002898 substrate binding site [chemical binding]; other site 694427002899 glutamase interaction surface [polypeptide binding]; other site 694427002900 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 694427002901 active site 694427002902 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427002903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002904 TPR motif; other site 694427002905 binding surface 694427002906 Bacterial SH3 domain; Region: SH3_3; cl02551 694427002907 Oxygen tolerance; Region: BatD; pfam13584 694427002908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002909 TPR motif; other site 694427002910 binding surface 694427002911 TPR repeat; Region: TPR_11; pfam13414 694427002912 Aerotolerance regulator N-terminal; Region: BatA; cl06567 694427002913 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 694427002914 metal ion-dependent adhesion site (MIDAS); other site 694427002915 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 694427002916 metal ion-dependent adhesion site (MIDAS); other site 694427002917 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 694427002918 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 694427002919 metal ion-dependent adhesion site (MIDAS); other site 694427002920 MoxR-like ATPases [General function prediction only]; Region: COG0714 694427002921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427002922 Walker A motif; other site 694427002923 ATP binding site [chemical binding]; other site 694427002924 Walker B motif; other site 694427002925 arginine finger; other site 694427002926 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694427002927 IHF - DNA interface [nucleotide binding]; other site 694427002928 IHF dimer interface [polypeptide binding]; other site 694427002929 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 694427002930 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 694427002931 IHF dimer interface [polypeptide binding]; other site 694427002932 IHF - DNA interface [nucleotide binding]; other site 694427002933 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 694427002934 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694427002935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427002936 FeS/SAM binding site; other site 694427002937 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 694427002938 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 694427002939 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 694427002940 P loop; other site 694427002941 GTP binding site [chemical binding]; other site 694427002942 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 694427002943 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 694427002944 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 694427002945 competence damage-inducible protein A; Provisional; Region: PRK00549 694427002946 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 694427002947 putative MPT binding site; other site 694427002948 Competence-damaged protein; Region: CinA; cl00666 694427002949 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 694427002950 Predicted membrane protein [Function unknown]; Region: COG2860 694427002951 UPF0126 domain; Region: UPF0126; pfam03458 694427002952 UPF0126 domain; Region: UPF0126; pfam03458 694427002953 Preprotein translocase SecG subunit; Region: SecG; cl09123 694427002954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427002955 Walker A motif; other site 694427002956 ATP binding site [chemical binding]; other site 694427002957 Walker B motif; other site 694427002958 arginine finger; other site 694427002959 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 694427002960 Helix-turn-helix domains; Region: HTH; cl00088 694427002961 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427002962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427002963 binding surface 694427002964 TPR motif; other site 694427002965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002966 binding surface 694427002967 TPR motif; other site 694427002968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427002969 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 694427002970 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427002971 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 694427002972 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 694427002973 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 694427002974 putative active site [active] 694427002975 putative catalytic site [active] 694427002976 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 694427002977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427002978 active site 694427002979 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 694427002980 oligomerisation interface [polypeptide binding]; other site 694427002981 mobile loop; other site 694427002982 roof hairpin; other site 694427002983 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 694427002984 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 694427002985 ring oligomerisation interface [polypeptide binding]; other site 694427002986 ATP/Mg binding site [chemical binding]; other site 694427002987 stacking interactions; other site 694427002988 hinge regions; other site 694427002989 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 694427002990 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 694427002991 active site 694427002992 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427002993 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 694427002994 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 694427002995 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 694427002996 ATP-binding site [chemical binding]; other site 694427002997 Sugar specificity; other site 694427002998 Pyrimidine base specificity; other site 694427002999 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 694427003000 active site 694427003001 catalytic site [active] 694427003002 substrate binding site [chemical binding]; other site 694427003003 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694427003004 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 694427003005 substrate binding pocket [chemical binding]; other site 694427003006 membrane-bound complex binding site; other site 694427003007 hinge residues; other site 694427003008 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 694427003009 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694427003010 catalytic residue [active] 694427003011 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 694427003012 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 694427003013 phosphoserine phosphatase SerB; Region: serB; TIGR00338 694427003014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427003015 motif II; other site 694427003016 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 694427003017 NADH(P)-binding; Region: NAD_binding_10; pfam13460 694427003018 NAD binding site [chemical binding]; other site 694427003019 active site 694427003020 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 694427003021 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 694427003022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003023 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 694427003024 Type III pantothenate kinase; Region: Pan_kinase; cl09130 694427003025 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 694427003026 ATP phosphoribosyltransferase; Region: HisG; cl15266 694427003027 HisG, C-terminal domain; Region: HisG_C; cl06867 694427003028 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427003029 AMP-binding enzyme; Region: AMP-binding; cl15778 694427003030 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 694427003031 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 694427003032 putative tRNA-binding site [nucleotide binding]; other site 694427003033 B3/4 domain; Region: B3_4; cl11458 694427003034 tRNA synthetase B5 domain; Region: B5; cl08394 694427003035 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 694427003036 dimer interface [polypeptide binding]; other site 694427003037 motif 1; other site 694427003038 motif 3; other site 694427003039 motif 2; other site 694427003040 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 694427003041 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427003042 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 694427003043 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427003044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427003045 catalytic residue [active] 694427003046 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 694427003047 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 694427003048 NADP binding site [chemical binding]; other site 694427003049 active site 694427003050 putative substrate binding site [chemical binding]; other site 694427003051 Cupin domain; Region: Cupin_2; cl09118 694427003052 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 694427003053 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 694427003054 substrate binding site; other site 694427003055 tetramer interface; other site 694427003056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427003057 RNA binding surface [nucleotide binding]; other site 694427003058 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 694427003059 putative active site [active] 694427003060 catalytic residue [active] 694427003061 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 694427003062 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 694427003063 5S rRNA interface [nucleotide binding]; other site 694427003064 CTC domain interface [polypeptide binding]; other site 694427003065 L16 interface [polypeptide binding]; other site 694427003066 aspartate aminotransferase; Provisional; Region: PRK05764 694427003067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003069 homodimer interface [polypeptide binding]; other site 694427003070 catalytic residue [active] 694427003071 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 694427003072 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 694427003073 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 694427003074 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 694427003075 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 694427003076 23S rRNA binding site [nucleotide binding]; other site 694427003077 ribosomal protein L20; Region: rpl20; CHL00068 694427003078 L21 binding site [polypeptide binding]; other site 694427003079 L13 binding site [polypeptide binding]; other site 694427003080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 694427003081 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 694427003082 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 694427003083 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 694427003084 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 694427003085 homodimer interface [polypeptide binding]; other site 694427003086 NADP binding site [chemical binding]; other site 694427003087 substrate binding site [chemical binding]; other site 694427003088 signal recognition particle protein; Provisional; Region: PRK10867 694427003089 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 694427003090 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 694427003091 P loop; other site 694427003092 GTP binding site [chemical binding]; other site 694427003093 Signal peptide binding domain; Region: SRP_SPB; pfam02978 694427003094 Protein of unknown function, DUF479; Region: DUF479; cl01203 694427003095 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427003096 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 694427003097 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 694427003098 Catalytic dyad [active] 694427003099 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 694427003100 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 694427003101 active site 694427003102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427003103 Helix-turn-helix domains; Region: HTH; cl00088 694427003104 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 694427003105 dimer interface [polypeptide binding]; other site 694427003106 FMN binding site [chemical binding]; other site 694427003107 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 694427003108 dimer interface [polypeptide binding]; other site 694427003109 FMN binding site [chemical binding]; other site 694427003110 S-adenosylmethionine synthetase; Validated; Region: PRK05250 694427003111 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 694427003112 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 694427003113 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 694427003114 Protein of unknown function, DUF393; Region: DUF393; cl01136 694427003115 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 694427003116 Transglycosylase; Region: Transgly; cl07896 694427003117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427003118 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427003119 Ion channel; Region: Ion_trans_2; cl11596 694427003120 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 694427003121 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 694427003122 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 694427003123 RNA binding site [nucleotide binding]; other site 694427003124 active site 694427003125 Bacitracin resistance protein BacA; Region: BacA; cl00858 694427003126 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 694427003127 FtsX-like permease family; Region: FtsX; cl15850 694427003128 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 694427003129 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 694427003130 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 694427003131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427003132 catalytic residue [active] 694427003133 Fe-S metabolism associated domain; Region: SufE; cl00951 694427003134 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 694427003135 active site 694427003136 putative DNA-binding cleft [nucleotide binding]; other site 694427003137 dimer interface [polypeptide binding]; other site 694427003138 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 694427003139 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 694427003140 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427003141 DNA repair protein RadA; Provisional; Region: PRK11823 694427003142 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 694427003143 Walker A motif/ATP binding site; other site 694427003144 ATP binding site [chemical binding]; other site 694427003145 Walker B motif; other site 694427003146 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 694427003147 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 694427003148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427003149 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 694427003150 MatE; Region: MatE; cl10513 694427003151 MatE; Region: MatE; cl10513 694427003152 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 694427003153 MG2 domain; Region: A2M_N; pfam01835 694427003154 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 694427003155 Alpha-2-macroglobulin family; Region: A2M; pfam00207 694427003156 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 694427003157 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 694427003158 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 694427003159 putative ATP binding site [chemical binding]; other site 694427003160 putative substrate interface [chemical binding]; other site 694427003161 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427003162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003163 binding surface 694427003164 TPR motif; other site 694427003165 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 694427003166 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 694427003167 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 694427003168 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 694427003169 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 694427003170 DoxX; Region: DoxX; cl00976 694427003171 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427003172 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 694427003173 substrate binding site [chemical binding]; other site 694427003174 dimer interface [polypeptide binding]; other site 694427003175 catalytic triad [active] 694427003176 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 694427003177 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 694427003178 Tannase and feruloyl esterase; Region: Tannase; pfam07519 694427003179 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 694427003180 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427003181 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427003182 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427003183 ligand binding site [chemical binding]; other site 694427003184 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427003185 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427003186 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 694427003187 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694427003188 putative active site [active] 694427003189 putative metal binding site [ion binding]; other site 694427003190 Domain of unknown function DUF59; Region: DUF59; cl00941 694427003191 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694427003192 active site 694427003193 O-methyltransferase; Region: Methyltransf_3; pfam01596 694427003194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003195 S-adenosylmethionine binding site [chemical binding]; other site 694427003196 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427003197 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427003198 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427003199 DNA topoisomerase III; Provisional; Region: PRK07726 694427003200 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 694427003201 active site 694427003202 putative interdomain interaction site [polypeptide binding]; other site 694427003203 putative metal-binding site [ion binding]; other site 694427003204 putative nucleotide binding site [chemical binding]; other site 694427003205 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 694427003206 domain I; other site 694427003207 DNA binding groove [nucleotide binding] 694427003208 phosphate binding site [ion binding]; other site 694427003209 domain II; other site 694427003210 domain III; other site 694427003211 nucleotide binding site [chemical binding]; other site 694427003212 catalytic site [active] 694427003213 domain IV; other site 694427003214 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 694427003215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427003216 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 694427003217 NAD synthetase; Reviewed; Region: nadE; PRK02628 694427003218 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 694427003219 multimer interface [polypeptide binding]; other site 694427003220 active site 694427003221 catalytic triad [active] 694427003222 protein interface 1 [polypeptide binding]; other site 694427003223 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 694427003224 homodimer interface [polypeptide binding]; other site 694427003225 NAD binding pocket [chemical binding]; other site 694427003226 ATP binding pocket [chemical binding]; other site 694427003227 Mg binding site [ion binding]; other site 694427003228 active-site loop [active] 694427003229 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 694427003230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 694427003231 seryl-tRNA synthetase; Provisional; Region: PRK05431 694427003232 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 694427003233 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 694427003234 dimer interface [polypeptide binding]; other site 694427003235 active site 694427003236 motif 1; other site 694427003237 motif 2; other site 694427003238 motif 3; other site 694427003239 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 694427003240 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 694427003241 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 694427003242 putative active site [active] 694427003243 metal binding site [ion binding]; metal-binding site 694427003244 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 694427003245 4-alpha-glucanotransferase; Region: PLN02950 694427003246 starch-binding site 2 [chemical binding]; other site 694427003247 starch-binding site 1 [chemical binding]; other site 694427003248 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 694427003249 starch-binding site 2 [chemical binding]; other site 694427003250 starch-binding site 1 [chemical binding]; other site 694427003251 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 694427003252 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 694427003253 dimerization interface [polypeptide binding]; other site 694427003254 ATP binding site [chemical binding]; other site 694427003255 MarC family integral membrane protein; Region: MarC; cl00919 694427003256 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 694427003257 Probable Catalytic site; other site 694427003258 metal-binding site 694427003259 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 694427003260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427003261 putative ADP-binding pocket [chemical binding]; other site 694427003262 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 694427003263 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 694427003264 Ligand binding site; other site 694427003265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427003266 active site 694427003267 Protein of unknown function DUF70; Region: DUF70; cl00785 694427003268 MatE; Region: MatE; cl10513 694427003269 Domain of unknown function DUF77; Region: DUF77; cl00307 694427003270 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 694427003271 Sporulation related domain; Region: SPOR; cl10051 694427003272 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 694427003273 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 694427003274 NAD binding site [chemical binding]; other site 694427003275 substrate binding site [chemical binding]; other site 694427003276 homodimer interface [polypeptide binding]; other site 694427003277 active site 694427003278 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 694427003279 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694427003280 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 694427003281 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 694427003282 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 694427003283 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 694427003284 putative active site [active] 694427003285 oxyanion strand; other site 694427003286 catalytic triad [active] 694427003287 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 694427003288 tetramerization interface [polypeptide binding]; other site 694427003289 active site 694427003290 Pantoate-beta-alanine ligase; Region: PanC; cd00560 694427003291 pantoate--beta-alanine ligase; Region: panC; TIGR00018 694427003292 active site 694427003293 ATP-binding site [chemical binding]; other site 694427003294 pantoate-binding site; other site 694427003295 HXXH motif; other site 694427003296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427003297 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 694427003298 GTP-binding protein Der; Reviewed; Region: PRK00093 694427003299 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 694427003300 G1 box; other site 694427003301 GTP/Mg2+ binding site [chemical binding]; other site 694427003302 Switch I region; other site 694427003303 G2 box; other site 694427003304 Switch II region; other site 694427003305 G3 box; other site 694427003306 G4 box; other site 694427003307 G5 box; other site 694427003308 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 694427003309 G1 box; other site 694427003310 GTP/Mg2+ binding site [chemical binding]; other site 694427003311 Switch I region; other site 694427003312 G2 box; other site 694427003313 G3 box; other site 694427003314 Switch II region; other site 694427003315 G4 box; other site 694427003316 G5 box; other site 694427003317 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427003318 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427003319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427003320 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 694427003321 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 694427003322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427003323 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 694427003324 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427003325 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 694427003326 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 694427003327 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 694427003328 dimer interface [polypeptide binding]; other site 694427003329 decamer (pentamer of dimers) interface [polypeptide binding]; other site 694427003330 catalytic triad [active] 694427003331 peroxidatic and resolving cysteines [active] 694427003332 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 694427003333 homotrimer interaction site [polypeptide binding]; other site 694427003334 zinc binding site [ion binding]; other site 694427003335 CDP-binding sites; other site 694427003336 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 694427003337 active site 694427003338 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427003339 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 694427003340 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 694427003341 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 694427003342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003343 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003344 active site 694427003345 HIGH motif; other site 694427003346 nucleotide binding site [chemical binding]; other site 694427003347 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003348 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 694427003349 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003350 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 694427003351 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003352 active site 694427003353 KMSKS motif; other site 694427003354 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694427003355 tRNA binding surface [nucleotide binding]; other site 694427003356 anticodon binding site; other site 694427003357 Uncharacterized conserved protein [Function unknown]; Region: COG1284 694427003358 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 694427003359 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 694427003360 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 694427003361 colanic acid exporter; Provisional; Region: PRK10459 694427003362 MatE; Region: MatE; cl10513 694427003363 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427003364 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 694427003365 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 694427003366 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427003367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427003368 active site 694427003369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003370 S-adenosylmethionine binding site [chemical binding]; other site 694427003371 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 694427003372 active site 694427003373 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 694427003374 homodimer interface [polypeptide binding]; other site 694427003375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427003376 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 694427003377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003378 S-adenosylmethionine binding site [chemical binding]; other site 694427003379 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 694427003380 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 694427003381 HIGH motif; other site 694427003382 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 694427003383 active site 694427003384 KMSKS motif; other site 694427003385 elongation factor Ts; Provisional; Region: tsf; PRK09377 694427003386 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 694427003387 Elongation factor TS; Region: EF_TS; pfam00889 694427003388 Elongation factor TS; Region: EF_TS; pfam00889 694427003389 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 694427003390 rRNA interaction site [nucleotide binding]; other site 694427003391 S8 interaction site; other site 694427003392 putative laminin-1 binding site; other site 694427003393 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 694427003394 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 694427003395 23S rRNA interface [nucleotide binding]; other site 694427003396 L3 interface [polypeptide binding]; other site 694427003397 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 694427003398 active site 694427003399 DNA binding site [nucleotide binding] 694427003400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427003401 Walker A/P-loop; other site 694427003402 ATP binding site [chemical binding]; other site 694427003403 Q-loop/lid; other site 694427003404 ABC transporter signature motif; other site 694427003405 Walker B; other site 694427003406 D-loop; other site 694427003407 H-loop/switch region; other site 694427003408 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 694427003409 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 694427003410 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427003411 Ca binding site [ion binding]; other site 694427003412 active site 694427003413 homodimer interface [polypeptide binding]; other site 694427003414 catalytic site [active] 694427003415 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 694427003416 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 694427003417 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 694427003418 putative catalytic site [active] 694427003419 metal binding site A [ion binding]; metal-binding site 694427003420 phosphate binding site [ion binding]; other site 694427003421 metal binding site C [ion binding]; metal-binding site 694427003422 metal binding site B [ion binding]; metal-binding site 694427003423 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 694427003424 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 694427003425 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 694427003426 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 694427003427 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 694427003428 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 694427003429 active site 694427003430 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427003431 catalytic residues [active] 694427003432 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427003433 active site 694427003434 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 694427003435 dimer interface [polypeptide binding]; other site 694427003436 FMN binding site [chemical binding]; other site 694427003437 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427003438 dimer interface [polypeptide binding]; other site 694427003439 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 694427003440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427003441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427003442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427003443 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 694427003444 folate binding site [chemical binding]; other site 694427003445 NADP+ binding site [chemical binding]; other site 694427003446 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 694427003447 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 694427003448 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 694427003449 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 694427003450 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 694427003451 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 694427003452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427003453 active site 694427003454 motif I; other site 694427003455 motif II; other site 694427003456 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 694427003457 putative active site pocket [active] 694427003458 4-fold oligomerization interface [polypeptide binding]; other site 694427003459 metal binding residues [ion binding]; metal-binding site 694427003460 3-fold/trimer interface [polypeptide binding]; other site 694427003461 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 694427003462 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 694427003463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003465 homodimer interface [polypeptide binding]; other site 694427003466 catalytic residue [active] 694427003467 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 694427003468 ligand binding site [chemical binding]; other site 694427003469 active site 694427003470 UGI interface [polypeptide binding]; other site 694427003471 catalytic site [active] 694427003472 Uncharacterized conserved protein [Function unknown]; Region: COG2966 694427003473 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 694427003474 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 694427003475 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 694427003476 GAF domain; Region: GAF; cl15785 694427003477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003478 Walker A motif; other site 694427003479 ATP binding site [chemical binding]; other site 694427003480 Walker B motif; other site 694427003481 arginine finger; other site 694427003482 Helix-turn-helix domains; Region: HTH; cl00088 694427003483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427003484 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 694427003485 Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940 694427003486 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 694427003487 Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940 694427003488 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 694427003489 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003490 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003491 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910 694427003492 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 694427003493 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 694427003494 Nitrogen regulatory protein P-II; Region: P-II; cl00412 694427003495 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003496 Nitrogen regulatory protein P-II; Region: P-II; cl00412 694427003497 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003498 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 694427003499 nitrogenase reductase; Reviewed; Region: nifH; PRK13233 694427003500 Nucleotide-binding sites [chemical binding]; other site 694427003501 Walker A motif; other site 694427003502 Switch I region of nucleotide binding site; other site 694427003503 Fe4S4 binding sites [ion binding]; other site 694427003504 Switch II region of nucleotide binding site; other site 694427003505 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 694427003506 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 694427003507 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 694427003508 putative active site [active] 694427003509 catalytic site [active] 694427003510 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 694427003511 putative active site [active] 694427003512 catalytic site [active] 694427003513 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 694427003514 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 694427003515 catalytic motif [active] 694427003516 Zn binding site [ion binding]; other site 694427003517 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 694427003518 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 694427003519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003520 S-adenosylmethionine binding site [chemical binding]; other site 694427003521 EamA-like transporter family; Region: EamA; cl01037 694427003522 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 694427003523 EamA-like transporter family; Region: EamA; cl01037 694427003524 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427003525 RecX family; Region: RecX; cl00936 694427003526 Haemolysin-III related; Region: HlyIII; cl03831 694427003527 tRNA-specific 2-thiouridylase MnmA; Provisional; Region: mnmA; PRK14665 694427003528 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 694427003529 Ligand Binding Site [chemical binding]; other site 694427003530 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 694427003531 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 694427003532 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 694427003533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003534 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 694427003535 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 694427003536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427003537 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 694427003538 active site 694427003539 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427003540 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427003541 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427003542 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427003543 Protein of unknown function (DUF541); Region: SIMPL; cl01077 694427003544 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 694427003545 TfoX N-terminal domain; Region: TfoX_N; cl01167 694427003546 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 694427003547 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 694427003548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427003549 Coenzyme A binding pocket [chemical binding]; other site 694427003550 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 694427003551 putative active site [active] 694427003552 putative catalytic site [active] 694427003553 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 694427003554 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 694427003555 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 694427003556 Uncharacterized conserved protein [Function unknown]; Region: COG2006 694427003557 Domain of unknown function (DUF362); Region: DUF362; pfam04015 694427003558 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 694427003559 4Fe-4S binding domain; Region: Fer4_5; pfam12801 694427003560 4Fe-4S binding domain; Region: Fer4_5; pfam12801 694427003561 ferredoxin-type protein; Provisional; Region: PRK10194 694427003562 4Fe-4S binding domain; Region: Fer4; cl02805 694427003563 LysE type translocator; Region: LysE; cl00565 694427003564 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 694427003565 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427003566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427003567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427003568 DNA binding residues [nucleotide binding] 694427003569 NlpC/P60 family; Region: NLPC_P60; cl11438 694427003570 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 694427003571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427003572 Zn2+ binding site [ion binding]; other site 694427003573 Mg2+ binding site [ion binding]; other site 694427003574 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427003575 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 694427003576 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427003577 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 694427003578 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 694427003579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003581 homodimer interface [polypeptide binding]; other site 694427003582 catalytic residue [active] 694427003583 AMP-binding enzyme; Region: AMP-binding; cl15778 694427003584 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 694427003585 ACT domain-containing protein [General function prediction only]; Region: COG4747 694427003586 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 694427003587 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 694427003588 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427003589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427003590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427003591 DNA binding residues [nucleotide binding] 694427003592 glyoxylate reductase; Reviewed; Region: PRK13243 694427003593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003594 Rop-like; Region: Rop-like; cl02247 694427003595 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 694427003596 ArsC family; Region: ArsC; pfam03960 694427003597 putative catalytic residues [active] 694427003598 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427003599 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 694427003600 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 694427003601 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427003602 ligand binding site [chemical binding]; other site 694427003603 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 694427003604 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427003605 CoA-ligase; Region: Ligase_CoA; cl02894 694427003606 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 694427003607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003608 CoA-ligase; Region: Ligase_CoA; cl02894 694427003609 TOBE domain; Region: TOBE_2; cl01440 694427003610 TOBE domain; Region: TOBE_2; cl01440 694427003611 Helix-turn-helix domains; Region: HTH; cl00088 694427003612 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 694427003613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427003614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427003615 dimer interface [polypeptide binding]; other site 694427003616 conserved gate region; other site 694427003617 putative PBP binding loops; other site 694427003618 ABC-ATPase subunit interface; other site 694427003619 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 694427003620 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427003621 Walker A/P-loop; other site 694427003622 ATP binding site [chemical binding]; other site 694427003623 Q-loop/lid; other site 694427003624 ABC transporter signature motif; other site 694427003625 Walker B; other site 694427003626 D-loop; other site 694427003627 H-loop/switch region; other site 694427003628 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 694427003629 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 694427003630 Nucleotide-binding sites [chemical binding]; other site 694427003631 Walker A motif; other site 694427003632 Switch I region of nucleotide binding site; other site 694427003633 Fe4S4 binding sites [ion binding]; other site 694427003634 Switch II region of nucleotide binding site; other site 694427003635 Nitrogen regulatory protein P-II; Region: P-II; cl00412 694427003636 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003637 Nitrogen regulatory protein P-II; Region: P-II; cl00412 694427003638 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003639 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003640 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003641 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003642 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003643 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 694427003644 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003645 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003646 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003647 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 694427003648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427003649 FeS/SAM binding site; other site 694427003650 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 694427003651 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 694427003652 dimer interface [polypeptide binding]; other site 694427003653 [2Fe-2S] cluster binding site [ion binding]; other site 694427003654 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 694427003655 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 694427003656 active site 694427003657 catalytic residues [active] 694427003658 metal binding site [ion binding]; metal-binding site 694427003659 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 694427003660 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 694427003661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427003662 Coenzyme A binding pocket [chemical binding]; other site 694427003663 Nif-specific regulatory protein; Region: nifA; TIGR01817 694427003664 GAF domain; Region: GAF; cl15785 694427003665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003666 Walker A motif; other site 694427003667 ATP binding site [chemical binding]; other site 694427003668 Walker B motif; other site 694427003669 arginine finger; other site 694427003670 Helix-turn-helix domains; Region: HTH; cl00088 694427003671 Nucleoside recognition; Region: Gate; cl00486 694427003672 Nucleoside recognition; Region: Gate; cl00486 694427003673 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 694427003674 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427003675 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 694427003676 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 694427003677 catalytic residue [active] 694427003678 putative FPP diphosphate binding site; other site 694427003679 putative FPP binding hydrophobic cleft; other site 694427003680 dimer interface [polypeptide binding]; other site 694427003681 putative IPP diphosphate binding site; other site 694427003682 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 694427003683 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 694427003684 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 694427003685 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 694427003686 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 694427003687 Surface antigen; Region: Bac_surface_Ag; cl03097 694427003688 periplasmic chaperone; Provisional; Region: PRK10780 694427003689 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 694427003690 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 694427003691 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 694427003692 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 694427003693 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 694427003694 DNA binding residues [nucleotide binding] 694427003695 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 694427003696 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 694427003697 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694427003698 catalytic residue [active] 694427003699 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427003700 putative peptidoglycan binding site; other site 694427003701 ParB-like partition proteins; Region: parB_part; TIGR00180 694427003702 ParB-like nuclease domain; Region: ParBc; cl02129 694427003703 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 694427003704 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 694427003705 P-loop; other site 694427003706 Magnesium ion binding site [ion binding]; other site 694427003707 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 694427003708 Magnesium ion binding site [ion binding]; other site 694427003709 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 694427003710 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427003711 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427003712 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427003713 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427003714 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427003715 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427003716 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427003717 active site 694427003718 metal binding site [ion binding]; metal-binding site 694427003719 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 694427003720 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427003721 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427003722 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 694427003723 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 694427003724 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 694427003725 Uncharacterized conserved protein [Function unknown]; Region: COG2966 694427003726 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 694427003727 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 694427003728 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 694427003729 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 694427003730 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 694427003731 putative NADH binding site [chemical binding]; other site 694427003732 putative active site [active] 694427003733 nudix motif; other site 694427003734 putative metal binding site [ion binding]; other site 694427003735 FeoA domain; Region: FeoA; cl00838 694427003736 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 694427003737 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 694427003738 G1 box; other site 694427003739 GTP/Mg2+ binding site [chemical binding]; other site 694427003740 Switch I region; other site 694427003741 G2 box; other site 694427003742 G3 box; other site 694427003743 Switch II region; other site 694427003744 G4 box; other site 694427003745 G5 box; other site 694427003746 Nucleoside recognition; Region: Gate; cl00486 694427003747 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 694427003748 Nucleoside recognition; Region: Gate; cl00486 694427003749 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 694427003750 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 694427003751 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427003752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427003753 DNA binding residues [nucleotide binding] 694427003754 dimerization interface [polypeptide binding]; other site 694427003755 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 694427003756 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 694427003757 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 694427003758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003759 Walker A motif; other site 694427003760 ATP binding site [chemical binding]; other site 694427003761 Walker B motif; other site 694427003762 arginine finger; other site 694427003763 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 694427003764 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 694427003765 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 694427003766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427003767 Helix-turn-helix domains; Region: HTH; cl00088 694427003768 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427003769 nudix motif; other site 694427003770 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 694427003771 Lumazine binding domain; Region: Lum_binding; pfam00677 694427003772 Lumazine binding domain; Region: Lum_binding; pfam00677 694427003773 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 694427003774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 694427003775 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 694427003776 synthetase active site [active] 694427003777 NTP binding site [chemical binding]; other site 694427003778 metal binding site [ion binding]; metal-binding site 694427003779 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 694427003780 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 694427003781 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 694427003782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003783 S-adenosylmethionine binding site [chemical binding]; other site 694427003784 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 694427003785 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 694427003786 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 694427003787 active site 694427003788 catalytic site [active] 694427003789 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 694427003790 Domain of unknown function (DUF386); Region: DUF386; cl01047 694427003791 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 694427003792 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 694427003793 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 694427003794 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 694427003795 dimer interface [polypeptide binding]; other site 694427003796 motif 1; other site 694427003797 active site 694427003798 motif 2; other site 694427003799 motif 3; other site 694427003800 TPR repeat; Region: TPR_11; pfam13414 694427003801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003802 binding surface 694427003803 TPR motif; other site 694427003804 TPR repeat; Region: TPR_11; pfam13414 694427003805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003806 binding surface 694427003807 TPR motif; other site 694427003808 TPR repeat; Region: TPR_11; pfam13414 694427003809 TPR repeat; Region: TPR_11; pfam13414 694427003810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003811 binding surface 694427003812 TPR motif; other site 694427003813 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 694427003814 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 694427003815 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 694427003816 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 694427003817 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 694427003818 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 694427003819 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 694427003820 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 694427003821 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 694427003822 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 694427003823 SurA N-terminal domain; Region: SurA_N_3; cl07813 694427003824 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427003825 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 694427003826 Domain of unknown function DUF21; Region: DUF21; pfam01595 694427003827 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694427003828 Transporter associated domain; Region: CorC_HlyC; cl08393 694427003829 GatB domain; Region: GatB_Yqey; cl11497 694427003830 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 694427003831 nucleotide binding site [chemical binding]; other site 694427003832 SulA interaction site; other site 694427003833 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 694427003834 Cell division protein FtsA; Region: FtsA; cl11496 694427003835 Cell division protein FtsA; Region: FtsA; cl11496 694427003836 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 694427003837 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427003838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427003839 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427003840 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 694427003841 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 694427003842 active site 694427003843 homodimer interface [polypeptide binding]; other site 694427003844 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 694427003845 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 694427003846 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427003847 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427003848 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 694427003849 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 694427003850 Mg++ binding site [ion binding]; other site 694427003851 putative catalytic motif [active] 694427003852 putative substrate binding site [chemical binding]; other site 694427003853 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 694427003854 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427003855 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427003856 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427003857 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 694427003858 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 694427003859 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427003860 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 694427003861 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 694427003862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003863 cell division protein MraZ; Reviewed; Region: PRK00326 694427003864 MraZ protein; Region: MraZ; pfam02381 694427003865 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427003866 putative acyl-acceptor binding pocket; other site 694427003867 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427003868 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 694427003869 RimM N-terminal domain; Region: RimM; pfam01782 694427003870 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 694427003871 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 694427003872 homodimer interface [polypeptide binding]; other site 694427003873 substrate-cofactor binding pocket; other site 694427003874 catalytic residue [active] 694427003875 WbqC-like protein family; Region: WbqC; pfam08889 694427003876 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 694427003877 signal peptidase I; Provisional; Region: PRK10861 694427003878 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427003879 dihydrodipicolinate reductase; Provisional; Region: PRK00048 694427003880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003881 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 694427003882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427003883 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 694427003884 active site 694427003885 dimer interface [polypeptide binding]; other site 694427003886 metal binding site [ion binding]; metal-binding site 694427003887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427003888 dimerization interface [polypeptide binding]; other site 694427003889 putative DNA binding site [nucleotide binding]; other site 694427003890 putative Zn2+ binding site [ion binding]; other site 694427003891 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427003892 catalytic residues [active] 694427003893 NeuB family; Region: NeuB; cl00496 694427003894 Chorismate mutase type II; Region: CM_2; cl00693 694427003895 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 694427003896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003898 homodimer interface [polypeptide binding]; other site 694427003899 catalytic residue [active] 694427003900 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 694427003901 Prephenate dehydratase; Region: PDT; pfam00800 694427003902 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 694427003903 putative L-Phe binding site [chemical binding]; other site 694427003904 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 694427003905 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 694427003906 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 694427003907 DNA binding site [nucleotide binding] 694427003908 active site 694427003909 AMP-binding enzyme; Region: AMP-binding; cl15778 694427003910 acyl-CoA synthetase; Validated; Region: PRK07798 694427003911 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 694427003912 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 694427003913 active site 694427003914 UbiA prenyltransferase family; Region: UbiA; cl00337 694427003915 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 694427003916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 694427003917 substrate binding site [chemical binding]; other site 694427003918 oxyanion hole (OAH) forming residues; other site 694427003919 trimer interface [polypeptide binding]; other site 694427003920 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 694427003921 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 694427003922 dimer interface [polypeptide binding]; other site 694427003923 tetramer interface [polypeptide binding]; other site 694427003924 PYR/PP interface [polypeptide binding]; other site 694427003925 TPP binding site [chemical binding]; other site 694427003926 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 694427003927 TPP-binding site; other site 694427003928 chorismate binding enzyme; Region: Chorismate_bind; cl10555 694427003929 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 694427003930 CoenzymeA binding site [chemical binding]; other site 694427003931 subunit interaction site [polypeptide binding]; other site 694427003932 PHB binding site; other site 694427003933 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 694427003934 active site 694427003935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427003936 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427003937 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 694427003938 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 694427003939 Peptidase family C69; Region: Peptidase_C69; pfam03577 694427003940 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 694427003941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 694427003942 LytTr DNA-binding domain; Region: LytTR; cl04498 694427003943 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427003944 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427003945 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 694427003946 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 694427003947 Domain of unknown function (DUF2027); Region: DUF2027; pfam09640 694427003948 Smr domain; Region: Smr; cl02619 694427003949 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 694427003950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427003951 active site 694427003952 phosphorylation site [posttranslational modification] 694427003953 intermolecular recognition site; other site 694427003954 dimerization interface [polypeptide binding]; other site 694427003955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427003956 DNA binding site [nucleotide binding] 694427003957 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 694427003958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427003959 dimer interface [polypeptide binding]; other site 694427003960 phosphorylation site [posttranslational modification] 694427003961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427003962 ATP binding site [chemical binding]; other site 694427003963 Mg2+ binding site [ion binding]; other site 694427003964 G-X-G motif; other site 694427003965 Amino acid permease; Region: AA_permease_2; pfam13520 694427003966 K+ potassium transporter; Region: K_trans; cl15781 694427003967 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 694427003968 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 694427003969 PAS domain S-box; Region: sensory_box; TIGR00229 694427003970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427003971 putative active site [active] 694427003972 heme pocket [chemical binding]; other site 694427003973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427003974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427003975 ATP binding site [chemical binding]; other site 694427003976 Mg2+ binding site [ion binding]; other site 694427003977 G-X-G motif; other site 694427003978 GMP synthase; Reviewed; Region: guaA; PRK00074 694427003979 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 694427003980 AMP/PPi binding site [chemical binding]; other site 694427003981 candidate oxyanion hole; other site 694427003982 catalytic triad [active] 694427003983 potential glutamine specificity residues [chemical binding]; other site 694427003984 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 694427003985 ATP Binding subdomain [chemical binding]; other site 694427003986 Ligand Binding sites [chemical binding]; other site 694427003987 Dimerization subdomain; other site 694427003988 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 694427003989 active site 694427003990 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427003991 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427003992 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427003993 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427003994 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427003995 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427003996 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 694427003997 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 694427003998 O-Antigen ligase; Region: Wzy_C; cl04850 694427003999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427004000 binding surface 694427004001 TPR motif; other site 694427004002 TPR repeat; Region: TPR_11; pfam13414 694427004003 signal peptidase I; Provisional; Region: PRK10861 694427004004 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427004005 Catalytic site [active] 694427004006 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427004007 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 694427004008 NVEALA protein; Region: NVEALA; pfam14055 694427004009 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 694427004010 NVEALA protein; Region: NVEALA; pfam14055 694427004011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427004012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004013 ATP binding site [chemical binding]; other site 694427004014 Mg2+ binding site [ion binding]; other site 694427004015 G-X-G motif; other site 694427004016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004018 active site 694427004019 phosphorylation site [posttranslational modification] 694427004020 intermolecular recognition site; other site 694427004021 dimerization interface [polypeptide binding]; other site 694427004022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004023 DNA binding site [nucleotide binding] 694427004024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427004025 non-specific DNA binding site [nucleotide binding]; other site 694427004026 salt bridge; other site 694427004027 sequence-specific DNA binding site [nucleotide binding]; other site 694427004028 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 694427004029 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427004030 putative active site [active] 694427004031 putative metal binding site [ion binding]; other site 694427004032 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 694427004033 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 694427004034 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 694427004035 DNA primase, catalytic core; Region: dnaG; TIGR01391 694427004036 CHC2 zinc finger; Region: zf-CHC2; cl15369 694427004037 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 694427004038 Virulence-associated protein E; Region: VirE; pfam05272 694427004039 Protein of unknown function (DUF3853); Region: DUF3853; pfam12964 694427004040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427004041 active site 694427004042 DNA binding site [nucleotide binding] 694427004043 Int/Topo IB signature motif; other site 694427004044 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694427004045 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694427004046 dimer interface [polypeptide binding]; other site 694427004047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004048 catalytic residue [active] 694427004049 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 694427004050 thiS-thiF/thiG interaction site; other site 694427004051 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 694427004052 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 694427004053 ATP binding site [chemical binding]; other site 694427004054 substrate interface [chemical binding]; other site 694427004055 DsrE/DsrF-like family; Region: DrsE; cl00672 694427004056 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 694427004057 CPxP motif; other site 694427004058 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 694427004059 MPN+ (JAMM) motif; other site 694427004060 Zinc-binding site [ion binding]; other site 694427004061 serine O-acetyltransferase; Region: cysE; TIGR01172 694427004062 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694427004063 trimer interface [polypeptide binding]; other site 694427004064 active site 694427004065 substrate binding site [chemical binding]; other site 694427004066 CoA binding site [chemical binding]; other site 694427004067 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427004068 ligand binding site [chemical binding]; other site 694427004069 flexible hinge region; other site 694427004070 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 694427004071 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 694427004072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427004073 catalytic residue [active] 694427004074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 694427004075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004076 Coenzyme A binding pocket [chemical binding]; other site 694427004077 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427004078 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 694427004079 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 694427004080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427004081 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004082 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004083 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427004084 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427004085 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427004086 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427004087 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 694427004088 Sulfatase; Region: Sulfatase; cl10460 694427004089 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 694427004090 Sulfatase; Region: Sulfatase; cl10460 694427004091 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 694427004092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427004093 Uncharacterized conserved protein [Function unknown]; Region: COG5361 694427004094 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 694427004095 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 694427004096 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694427004097 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694427004098 dimer interface [polypeptide binding]; other site 694427004099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004100 catalytic residue [active] 694427004101 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 694427004102 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 694427004103 homodimer interface [polypeptide binding]; other site 694427004104 substrate-cofactor binding pocket; other site 694427004105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004106 catalytic residue [active] 694427004107 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004108 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004109 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427004110 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427004111 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427004112 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427004113 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427004114 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427004115 catalytic residues [active] 694427004116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427004117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427004118 DNA binding residues [nucleotide binding] 694427004119 dimerization interface [polypeptide binding]; other site 694427004120 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 694427004121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427004122 FeS/SAM binding site; other site 694427004123 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 694427004124 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427004125 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 694427004126 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427004127 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427004128 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 694427004129 CPxP motif; other site 694427004130 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004131 active site 694427004132 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004133 metal binding site [ion binding]; metal-binding site 694427004134 ligand binding site [chemical binding]; other site 694427004135 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427004136 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 694427004137 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 694427004138 putative active site [active] 694427004139 putative catalytic site [active] 694427004140 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 694427004141 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427004142 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 694427004143 putative active site [active] 694427004144 putative catalytic site [active] 694427004145 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427004146 NPCBM/NEW2 domain; Region: NPCBM; cl07060 694427004147 NPCBM/NEW2 domain; Region: NPCBM; cl07060 694427004148 alpha-galactosidase; Region: PLN02229 694427004149 beta-D-glucuronidase; Provisional; Region: PRK10150 694427004150 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427004151 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427004152 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427004153 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004154 substrate binding site [chemical binding]; other site 694427004155 active site 694427004156 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004157 metal binding site [ion binding]; metal-binding site 694427004158 ligand binding site [chemical binding]; other site 694427004159 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004160 active site 694427004161 substrate binding site [chemical binding]; other site 694427004162 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004163 active site 694427004164 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004165 metal binding site [ion binding]; metal-binding site 694427004166 ligand binding site [chemical binding]; other site 694427004167 NPCBM/NEW2 domain; Region: NPCBM; cl07060 694427004168 Cadherin repeat-like domain; Region: CA_like; cl15786 694427004169 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427004170 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004171 substrate binding site [chemical binding]; other site 694427004172 active site 694427004173 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004174 metal binding site [ion binding]; metal-binding site 694427004175 ligand binding site [chemical binding]; other site 694427004176 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 694427004177 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 694427004178 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427004179 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427004180 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427004181 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 694427004182 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427004183 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427004184 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004185 ligand binding site [chemical binding]; other site 694427004186 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427004187 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427004188 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 694427004189 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 694427004190 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427004191 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427004192 PA14 domain; Region: PA14; cl08459 694427004193 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427004194 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427004195 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 694427004196 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427004197 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427004198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 694427004199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004200 ATP binding site [chemical binding]; other site 694427004201 Mg2+ binding site [ion binding]; other site 694427004202 G-X-G motif; other site 694427004203 Response regulator receiver domain; Region: Response_reg; pfam00072 694427004204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004205 active site 694427004206 phosphorylation site [posttranslational modification] 694427004207 intermolecular recognition site; other site 694427004208 dimerization interface [polypeptide binding]; other site 694427004209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427004210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004211 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 694427004212 putative symporter YagG; Provisional; Region: PRK09669 694427004213 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 694427004214 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004215 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427004216 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004217 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 694427004218 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004219 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 694427004220 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 694427004221 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004222 Putative esterase; Region: Esterase; pfam00756 694427004223 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004224 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004225 Putative esterase; Region: Esterase; pfam00756 694427004226 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004227 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004228 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004229 Putative esterase; Region: Esterase; pfam00756 694427004230 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004231 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 694427004232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004233 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004234 Putative esterase; Region: Esterase; pfam00756 694427004235 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004236 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004237 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 694427004238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004239 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004240 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004241 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004242 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004243 substrate binding site [chemical binding]; other site 694427004244 active site 694427004245 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004246 ligand binding site [chemical binding]; other site 694427004247 metal binding site [ion binding]; metal-binding site 694427004248 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427004249 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 694427004250 Ca binding site [ion binding]; other site 694427004251 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 694427004252 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 694427004253 active site 694427004254 NMT1-like family; Region: NMT1_2; cl15260 694427004255 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004256 active site 694427004257 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 694427004258 Carboxylesterase family; Region: COesterase; pfam00135 694427004259 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004260 substrate binding pocket [chemical binding]; other site 694427004261 catalytic triad [active] 694427004262 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 694427004263 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 694427004264 inhibitor binding site; inhibition site 694427004265 active site 694427004266 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 694427004267 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 694427004268 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004269 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427004270 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 694427004271 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 694427004272 RNase E interface [polypeptide binding]; other site 694427004273 trimer interface [polypeptide binding]; other site 694427004274 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 694427004275 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 694427004276 RNase E interface [polypeptide binding]; other site 694427004277 trimer interface [polypeptide binding]; other site 694427004278 active site 694427004279 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 694427004280 putative nucleic acid binding region [nucleotide binding]; other site 694427004281 G-X-X-G motif; other site 694427004282 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 694427004283 RNA binding site [nucleotide binding]; other site 694427004284 domain interface; other site 694427004285 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 694427004286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427004287 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 694427004288 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 694427004289 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 694427004290 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 694427004291 FAD binding site [chemical binding]; other site 694427004292 short chain dehydrogenase; Provisional; Region: PRK06197 694427004293 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 694427004294 putative NAD(P) binding site [chemical binding]; other site 694427004295 active site 694427004296 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 694427004297 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 694427004298 lipoprotein signal peptidase; Provisional; Region: PRK14787 694427004299 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 694427004300 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 694427004301 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427004302 active site 694427004303 HIGH motif; other site 694427004304 nucleotide binding site [chemical binding]; other site 694427004305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427004306 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427004307 active site 694427004308 KMSKS motif; other site 694427004309 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 694427004310 tRNA binding surface [nucleotide binding]; other site 694427004311 anticodon binding site; other site 694427004312 Protein of unknown function DUF262; Region: DUF262; cl14890 694427004313 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 694427004314 active site 694427004315 heat shock protein 90; Provisional; Region: PRK05218 694427004316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004317 ATP binding site [chemical binding]; other site 694427004318 Mg2+ binding site [ion binding]; other site 694427004319 G-X-G motif; other site 694427004320 Chorismate mutase type II; Region: CM_2; cl00693 694427004321 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 694427004322 active site 694427004323 catalytic residues [active] 694427004324 metal binding site [ion binding]; metal-binding site 694427004325 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 694427004326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004327 ATP binding site [chemical binding]; other site 694427004328 Mg2+ binding site [ion binding]; other site 694427004329 G-X-G motif; other site 694427004330 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 694427004331 anchoring element; other site 694427004332 dimer interface [polypeptide binding]; other site 694427004333 ATP binding site [chemical binding]; other site 694427004334 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 694427004335 active site 694427004336 putative metal-binding site [ion binding]; other site 694427004337 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 694427004338 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 694427004339 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 694427004340 active site 694427004341 catalytic residues [active] 694427004342 NeuB family; Region: NeuB; cl00496 694427004343 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 694427004344 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 694427004345 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 694427004346 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 694427004347 putative active site [active] 694427004348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 694427004349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427004350 FeS/SAM binding site; other site 694427004351 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 694427004352 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 694427004353 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 694427004354 metal binding site [ion binding]; metal-binding site 694427004355 dimer interface [polypeptide binding]; other site 694427004356 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 694427004357 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004358 PAS fold; Region: PAS_3; pfam08447 694427004359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427004360 DNA binding residues [nucleotide binding] 694427004361 dimerization interface [polypeptide binding]; other site 694427004362 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 694427004363 nucleotide binding site [chemical binding]; other site 694427004364 N-acetyl-L-glutamate binding site [chemical binding]; other site 694427004365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427004366 active site 694427004367 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 694427004368 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 694427004369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004370 Response regulator receiver domain; Region: Response_reg; pfam00072 694427004371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004372 active site 694427004373 phosphorylation site [posttranslational modification] 694427004374 intermolecular recognition site; other site 694427004375 dimerization interface [polypeptide binding]; other site 694427004376 PglZ domain; Region: PglZ; pfam08665 694427004377 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427004378 Smg-4/UPF3 family; Region: Smg4_UPF3; pfam03467 694427004379 CAAX protease self-immunity; Region: Abi; cl00558 694427004380 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 694427004381 RNA/DNA binding site [nucleotide binding]; other site 694427004382 RRM dimerization site [polypeptide binding]; other site 694427004383 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 694427004384 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 694427004385 putative catalytic cysteine [active] 694427004386 gamma-glutamyl kinase; Provisional; Region: PRK05429 694427004387 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 694427004388 nucleotide binding site [chemical binding]; other site 694427004389 homotetrameric interface [polypeptide binding]; other site 694427004390 putative phosphate binding site [ion binding]; other site 694427004391 putative allosteric binding site; other site 694427004392 PUA domain; Region: PUA; cl00607 694427004393 M28 Zn-Peptidases; Region: M28_like_6; cd08656 694427004394 metal binding site [ion binding]; metal-binding site 694427004395 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 694427004396 Ligand binding site [chemical binding]; other site 694427004397 Electron transfer flavoprotein domain; Region: ETF; pfam01012 694427004398 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 694427004399 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 694427004400 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 694427004401 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 694427004402 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 694427004403 active site 694427004404 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 694427004405 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 694427004406 DNA-binding site [nucleotide binding]; DNA binding site 694427004407 RNA-binding motif; other site 694427004408 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 694427004409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004410 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 694427004411 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 694427004412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004413 Coenzyme A binding pocket [chemical binding]; other site 694427004414 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694427004415 NAD-dependent deacetylase; Provisional; Region: PRK00481 694427004416 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 694427004417 NAD+ binding site [chemical binding]; other site 694427004418 substrate binding site [chemical binding]; other site 694427004419 Zn binding site [ion binding]; other site 694427004420 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 694427004421 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427004422 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 694427004423 active site 694427004424 DNA binding site [nucleotide binding] 694427004425 Int/Topo IB signature motif; other site 694427004426 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 694427004427 30S subunit binding site; other site 694427004428 elongation factor Tu; Reviewed; Region: PRK12735 694427004429 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 694427004430 G1 box; other site 694427004431 GEF interaction site [polypeptide binding]; other site 694427004432 GTP/Mg2+ binding site [chemical binding]; other site 694427004433 Switch I region; other site 694427004434 G2 box; other site 694427004435 G3 box; other site 694427004436 Switch II region; other site 694427004437 G4 box; other site 694427004438 G5 box; other site 694427004439 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 694427004440 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 694427004441 Antibiotic Binding Site [chemical binding]; other site 694427004442 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 694427004443 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 694427004444 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 694427004445 putative homodimer interface [polypeptide binding]; other site 694427004446 KOW motif; Region: KOW; cl00354 694427004447 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 694427004448 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 694427004449 23S rRNA interface [nucleotide binding]; other site 694427004450 L7/L12 interface [polypeptide binding]; other site 694427004451 putative thiostrepton binding site; other site 694427004452 L25 interface [polypeptide binding]; other site 694427004453 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 694427004454 mRNA/rRNA interface [nucleotide binding]; other site 694427004455 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 694427004456 23S rRNA interface [nucleotide binding]; other site 694427004457 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 694427004458 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 694427004459 core dimer interface [polypeptide binding]; other site 694427004460 peripheral dimer interface [polypeptide binding]; other site 694427004461 L10 interface [polypeptide binding]; other site 694427004462 L11 interface [polypeptide binding]; other site 694427004463 putative EF-Tu interaction site [polypeptide binding]; other site 694427004464 putative EF-G interaction site [polypeptide binding]; other site 694427004465 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 694427004466 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 694427004467 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 694427004468 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 694427004469 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 694427004470 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 694427004471 RPB11 interaction site [polypeptide binding]; other site 694427004472 RPB12 interaction site [polypeptide binding]; other site 694427004473 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 694427004474 RPB3 interaction site [polypeptide binding]; other site 694427004475 RPB1 interaction site [polypeptide binding]; other site 694427004476 RPB11 interaction site [polypeptide binding]; other site 694427004477 RPB10 interaction site [polypeptide binding]; other site 694427004478 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 694427004479 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 694427004480 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 694427004481 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 694427004482 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 694427004483 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 694427004484 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 694427004485 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 694427004486 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 694427004487 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 694427004488 DNA binding site [nucleotide binding] 694427004489 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 694427004490 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 694427004491 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 694427004492 Substrate binding site; other site 694427004493 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 694427004494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004495 ATP binding site [chemical binding]; other site 694427004496 Mg2+ binding site [ion binding]; other site 694427004497 G-X-G motif; other site 694427004498 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 694427004499 ATP binding site [chemical binding]; other site 694427004500 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 694427004501 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 694427004502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427004503 motif II; other site 694427004504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004506 active site 694427004507 phosphorylation site [posttranslational modification] 694427004508 intermolecular recognition site; other site 694427004509 dimerization interface [polypeptide binding]; other site 694427004510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004511 DNA binding site [nucleotide binding] 694427004512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004513 dimer interface [polypeptide binding]; other site 694427004514 phosphorylation site [posttranslational modification] 694427004515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004516 ATP binding site [chemical binding]; other site 694427004517 Mg2+ binding site [ion binding]; other site 694427004518 G-X-G motif; other site 694427004519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427004520 S-adenosylmethionine binding site [chemical binding]; other site 694427004521 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427004522 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427004523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427004525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427004526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427004527 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427004528 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427004529 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 694427004530 serpin-like protein; Provisional; Region: PHA02660 694427004531 reactive center loop; other site 694427004532 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427004533 Uncharacterized conserved protein [Function unknown]; Region: COG5276 694427004534 Uncharacterized conserved protein [Function unknown]; Region: COG5276 694427004535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004536 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 694427004537 NAD(P) binding site [chemical binding]; other site 694427004538 active site 694427004539 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 694427004540 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 694427004541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004542 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 694427004543 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427004544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427004545 catalytic residue [active] 694427004546 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 694427004547 MutS domain I; Region: MutS_I; pfam01624 694427004548 MutS domain II; Region: MutS_II; pfam05188 694427004549 MutS family domain IV; Region: MutS_IV; pfam05190 694427004550 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 694427004551 Walker A/P-loop; other site 694427004552 ATP binding site [chemical binding]; other site 694427004553 Q-loop/lid; other site 694427004554 ABC transporter signature motif; other site 694427004555 Walker B; other site 694427004556 D-loop; other site 694427004557 H-loop/switch region; other site 694427004558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427004559 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 694427004560 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 694427004561 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 694427004562 Sulfatase; Region: Sulfatase; cl10460 694427004563 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 694427004564 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 694427004565 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 694427004566 substrate binding pocket [chemical binding]; other site 694427004567 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 694427004568 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 694427004569 B12 binding site [chemical binding]; other site 694427004570 cobalt ligand [ion binding]; other site 694427004571 ORF6N domain; Region: ORF6N; pfam10543 694427004572 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 694427004573 putative recombination protein RecB; Provisional; Region: PRK13909 694427004574 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 694427004575 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 694427004576 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 694427004577 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 694427004578 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 694427004579 domain interface [polypeptide binding]; other site 694427004580 active site 694427004581 catalytic site [active] 694427004582 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 694427004583 domain interface [polypeptide binding]; other site 694427004584 active site 694427004585 catalytic site [active] 694427004586 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 694427004587 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004588 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427004589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427004590 putative substrate translocation pore; other site 694427004591 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427004592 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 694427004593 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 694427004594 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427004595 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694427004596 putative active site [active] 694427004597 putative metal binding site [ion binding]; other site 694427004598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427004599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694427004600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427004601 dimer interface [polypeptide binding]; other site 694427004602 conserved gate region; other site 694427004603 putative PBP binding loops; other site 694427004604 ABC-ATPase subunit interface; other site 694427004605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427004606 dimer interface [polypeptide binding]; other site 694427004607 conserved gate region; other site 694427004608 putative PBP binding loops; other site 694427004609 ABC-ATPase subunit interface; other site 694427004610 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14245 694427004611 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 694427004612 Walker A/P-loop; other site 694427004613 ATP binding site [chemical binding]; other site 694427004614 Q-loop/lid; other site 694427004615 ABC transporter signature motif; other site 694427004616 Walker B; other site 694427004617 D-loop; other site 694427004618 H-loop/switch region; other site 694427004619 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 694427004620 PhoU domain; Region: PhoU; pfam01895 694427004621 PhoU domain; Region: PhoU; pfam01895 694427004622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004624 active site 694427004625 phosphorylation site [posttranslational modification] 694427004626 intermolecular recognition site; other site 694427004627 dimerization interface [polypeptide binding]; other site 694427004628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004629 DNA binding site [nucleotide binding] 694427004630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 694427004631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 694427004632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004633 dimer interface [polypeptide binding]; other site 694427004634 phosphorylation site [posttranslational modification] 694427004635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004636 ATP binding site [chemical binding]; other site 694427004637 Mg2+ binding site [ion binding]; other site 694427004638 G-X-G motif; other site 694427004639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427004640 putative substrate translocation pore; other site 694427004641 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427004642 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427004643 ligand binding site [chemical binding]; other site 694427004644 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 694427004645 G1 box; other site 694427004646 putative GEF interaction site [polypeptide binding]; other site 694427004647 GTP/Mg2+ binding site [chemical binding]; other site 694427004648 elongation factor G; Reviewed; Region: PRK12740 694427004649 Switch I region; other site 694427004650 G2 box; other site 694427004651 G3 box; other site 694427004652 Switch II region; other site 694427004653 G4 box; other site 694427004654 G5 box; other site 694427004655 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 694427004656 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 694427004657 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 694427004658 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427004659 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 694427004660 glycyl-tRNA synthetase; Provisional; Region: PRK04173 694427004661 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 694427004662 motif 1; other site 694427004663 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 694427004664 active site 694427004665 motif 2; other site 694427004666 motif 3; other site 694427004667 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 694427004668 anticodon binding site; other site 694427004669 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 694427004670 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 694427004671 CAP-like domain; other site 694427004672 active site 694427004673 primary dimer interface [polypeptide binding]; other site 694427004674 OstA-like protein; Region: OstA_2; pfam13100 694427004675 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 694427004676 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427004677 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427004678 Protein of unknown function (DUF419); Region: DUF419; cl15265 694427004679 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004680 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427004681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 694427004682 DNA-binding site [nucleotide binding]; DNA binding site 694427004683 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 694427004684 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427004685 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 694427004686 Walker A/P-loop; other site 694427004687 ATP binding site [chemical binding]; other site 694427004688 Q-loop/lid; other site 694427004689 ABC transporter signature motif; other site 694427004690 Walker B; other site 694427004691 D-loop; other site 694427004692 H-loop/switch region; other site 694427004693 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 694427004694 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 694427004695 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 694427004696 active site 694427004697 HIGH motif; other site 694427004698 KMSKS motif; other site 694427004699 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 694427004700 tRNA binding surface [nucleotide binding]; other site 694427004701 anticodon binding site; other site 694427004702 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 694427004703 dimer interface [polypeptide binding]; other site 694427004704 putative tRNA-binding site [nucleotide binding]; other site 694427004705 Type III secretion needle MxiH like; Region: MxiH; cl09641 694427004706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 694427004707 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 694427004708 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 694427004709 FMN-binding domain; Region: FMN_bind; cl01081 694427004710 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 694427004711 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 694427004712 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 694427004713 generic binding surface II; other site 694427004714 generic binding surface I; other site 694427004715 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427004716 catalytic residues [active] 694427004717 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 694427004718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427004719 S-adenosylmethionine binding site [chemical binding]; other site 694427004720 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 694427004721 active site 694427004722 catalytic site [active] 694427004723 substrate binding site [chemical binding]; other site 694427004724 exodeoxyribonuclease X; Provisional; Region: PRK07983 694427004725 DNA polymerase III subunit beta; Validated; Region: PRK05643 694427004726 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 694427004727 putative DNA binding surface [nucleotide binding]; other site 694427004728 dimer interface [polypeptide binding]; other site 694427004729 beta-clamp/translesion DNA polymerase binding surface; other site 694427004730 beta-clamp/clamp loader binding surface; other site 694427004731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427004732 dimerization interface [polypeptide binding]; other site 694427004733 putative DNA binding site [nucleotide binding]; other site 694427004734 putative Zn2+ binding site [ion binding]; other site 694427004735 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427004736 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 694427004737 Predicted permeases [General function prediction only]; Region: COG0701 694427004738 Predicted permease; Region: DUF318; pfam03773 694427004739 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 694427004740 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427004741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427004742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427004743 dimerization interface [polypeptide binding]; other site 694427004744 putative DNA binding site [nucleotide binding]; other site 694427004745 putative Zn2+ binding site [ion binding]; other site 694427004746 Low molecular weight phosphatase family; Region: LMWPc; cd00115 694427004747 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 694427004748 active site 694427004749 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 694427004750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004751 Coenzyme A binding pocket [chemical binding]; other site 694427004752 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 694427004753 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 694427004754 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427004755 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 694427004756 Membrane transport protein; Region: Mem_trans; cl09117 694427004757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427004759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004760 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427004761 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 694427004762 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 694427004763 putative active cleft [active] 694427004764 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 694427004765 Putative carbohydrate binding domain; Region: CBM_X; cl05621 694427004766 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 694427004767 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 694427004768 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 694427004769 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 694427004770 alpha-galactosidase; Region: PLN02229 694427004771 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427004772 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004773 active site 694427004774 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427004775 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427004776 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427004777 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 694427004778 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427004779 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 694427004780 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004781 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 694427004782 homotrimer interaction site [polypeptide binding]; other site 694427004783 putative active site [active] 694427004784 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 694427004785 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427004786 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427004787 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 694427004788 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427004789 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427004790 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004791 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004792 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427004793 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427004794 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427004795 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 694427004796 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427004797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427004798 catalytic residue [active] 694427004799 translocation protein TolB; Provisional; Region: tolB; PRK01029 694427004800 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427004801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004802 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004803 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 694427004804 putative ABC transporter; Region: ycf24; CHL00085 694427004805 FeS assembly ATPase SufC; Region: sufC; TIGR01978 694427004806 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 694427004807 Walker A/P-loop; other site 694427004808 ATP binding site [chemical binding]; other site 694427004809 Q-loop/lid; other site 694427004810 ABC transporter signature motif; other site 694427004811 Walker B; other site 694427004812 D-loop; other site 694427004813 H-loop/switch region; other site 694427004814 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 694427004815 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 694427004816 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 694427004817 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 694427004818 putative active site [active] 694427004819 putative CoA binding site [chemical binding]; other site 694427004820 nudix motif; other site 694427004821 metal binding site [ion binding]; metal-binding site 694427004822 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 694427004823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427004824 RNA binding surface [nucleotide binding]; other site 694427004825 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 694427004826 probable active site [active] 694427004827 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 694427004828 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 694427004829 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 694427004830 active site 694427004831 HIGH motif; other site 694427004832 dimer interface [polypeptide binding]; other site 694427004833 KMSKS motif; other site 694427004834 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 694427004835 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 694427004836 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427004837 active site 694427004838 metal binding site [ion binding]; metal-binding site 694427004839 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 694427004840 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694427004841 dimer interface [polypeptide binding]; other site 694427004842 active site 694427004843 CoA binding pocket [chemical binding]; other site 694427004844 shikimate kinase; Reviewed; Region: aroK; PRK00131 694427004845 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 694427004846 ADP binding site [chemical binding]; other site 694427004847 magnesium binding site [ion binding]; other site 694427004848 putative shikimate binding site; other site 694427004849 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 694427004850 active site 694427004851 homodimer interface [polypeptide binding]; other site 694427004852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004853 GtrA-like protein; Region: GtrA; cl00971 694427004854 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 694427004855 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 694427004856 Putative esterase; Region: Esterase; pfam00756 694427004857 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427004858 Predicted ATPases [General function prediction only]; Region: COG1106 694427004859 RloB-like protein; Region: RloB; pfam13707 694427004860 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 694427004861 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 694427004862 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 694427004863 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 694427004864 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 694427004865 metal binding site [ion binding]; metal-binding site 694427004866 dimer interface [polypeptide binding]; other site 694427004867 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 694427004868 active site 694427004869 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 694427004870 active site 694427004871 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 694427004872 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 694427004873 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 694427004874 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 694427004875 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 694427004876 Domain of unknown function DUF21; Region: DUF21; pfam01595 694427004877 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 694427004878 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694427004879 Transporter associated domain; Region: CorC_HlyC; cl08393 694427004880 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 694427004881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427004882 ATP binding site [chemical binding]; other site 694427004883 putative Mg++ binding site [ion binding]; other site 694427004884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427004885 nucleotide binding region [chemical binding]; other site 694427004886 ATP-binding site [chemical binding]; other site 694427004887 RQC domain; Region: RQC; cl09632 694427004888 HRDC domain; Region: HRDC; cl02578 694427004889 MG2 domain; Region: A2M_N; pfam01835 694427004890 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427004891 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 694427004892 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427004893 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427004894 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004895 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427004896 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427004897 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 694427004898 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427004899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004900 dimer interface [polypeptide binding]; other site 694427004901 phosphorylation site [posttranslational modification] 694427004902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004903 ATP binding site [chemical binding]; other site 694427004904 Mg2+ binding site [ion binding]; other site 694427004905 G-X-G motif; other site 694427004906 Response regulator receiver domain; Region: Response_reg; pfam00072 694427004907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004908 active site 694427004909 phosphorylation site [posttranslational modification] 694427004910 intermolecular recognition site; other site 694427004911 dimerization interface [polypeptide binding]; other site 694427004912 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427004913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004914 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 694427004915 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 694427004916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427004917 Walker A motif; other site 694427004918 ATP binding site [chemical binding]; other site 694427004919 Walker B motif; other site 694427004920 arginine finger; other site 694427004921 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 694427004922 Clp protease; Region: CLP_protease; pfam00574 694427004923 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 694427004924 oligomer interface [polypeptide binding]; other site 694427004925 active site residues [active] 694427004926 trigger factor; Region: tig; TIGR00115 694427004927 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427004928 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 694427004929 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 694427004930 G1 box; other site 694427004931 putative GEF interaction site [polypeptide binding]; other site 694427004932 GTP/Mg2+ binding site [chemical binding]; other site 694427004933 Switch I region; other site 694427004934 G2 box; other site 694427004935 G3 box; other site 694427004936 Switch II region; other site 694427004937 G4 box; other site 694427004938 G5 box; other site 694427004939 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 694427004940 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 694427004941 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 694427004942 Permease; Region: Permease; cl00510 694427004943 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 694427004944 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 694427004945 Walker A/P-loop; other site 694427004946 ATP binding site [chemical binding]; other site 694427004947 Q-loop/lid; other site 694427004948 ABC transporter signature motif; other site 694427004949 Walker B; other site 694427004950 D-loop; other site 694427004951 H-loop/switch region; other site 694427004952 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 694427004953 putative active site [active] 694427004954 putative catalytic site [active] 694427004955 putative DNA binding site [nucleotide binding]; other site 694427004956 putative phosphate binding site [ion binding]; other site 694427004957 metal binding site A [ion binding]; metal-binding site 694427004958 putative AP binding site [nucleotide binding]; other site 694427004959 putative metal binding site B [ion binding]; other site 694427004960 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 694427004961 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427004962 N-terminal plug; other site 694427004963 ligand-binding site [chemical binding]; other site 694427004964 fumarate hydratase; Provisional; Region: PRK15389 694427004965 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 694427004966 Fumarase C-terminus; Region: Fumerase_C; cl00795 694427004967 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427004968 catalytic residues [active] 694427004969 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 694427004970 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427004971 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427004972 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 694427004973 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 694427004974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 694427004975 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 694427004976 active site 694427004977 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 694427004978 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 694427004979 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 694427004980 synthetase active site [active] 694427004981 NTP binding site [chemical binding]; other site 694427004982 metal binding site [ion binding]; metal-binding site 694427004983 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 694427004984 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 694427004985 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694427004986 active site residue [active] 694427004987 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 694427004988 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 694427004989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004990 EamA-like transporter family; Region: EamA; cl01037 694427004991 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 694427004992 EamA-like transporter family; Region: EamA; cl01037 694427004993 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 694427004994 Membrane transport protein; Region: Mem_trans; cl09117 694427004995 KWG Leptospira; Region: KWG; pfam07656 694427004996 primosome assembly protein PriA; Validated; Region: PRK05580 694427004997 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 694427004998 primosome assembly protein PriA; Validated; Region: PRK05580 694427004999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427005000 ATP binding site [chemical binding]; other site 694427005001 putative Mg++ binding site [ion binding]; other site 694427005002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427005003 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 694427005004 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 694427005005 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 694427005006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427005007 Walker A/P-loop; other site 694427005008 ATP binding site [chemical binding]; other site 694427005009 Q-loop/lid; other site 694427005010 ABC transporter signature motif; other site 694427005011 Walker B; other site 694427005012 D-loop; other site 694427005013 H-loop/switch region; other site 694427005014 Arginine repressor [Transcription]; Region: ArgR; COG1438 694427005015 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 694427005016 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 694427005017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 694427005018 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427005019 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 694427005020 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 694427005021 Ligand Binding Site [chemical binding]; other site 694427005022 elongation factor P; Validated; Region: PRK00529 694427005023 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 694427005024 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 694427005025 RNA binding site [nucleotide binding]; other site 694427005026 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 694427005027 RNA binding site [nucleotide binding]; other site 694427005028 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 694427005029 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 694427005030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427005031 active site 694427005032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005034 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 694427005035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005039 binding surface 694427005040 TPR motif; other site 694427005041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005042 Lyase; Region: Lyase_1; pfam00206 694427005043 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 694427005044 active sites [active] 694427005045 tetramer interface [polypeptide binding]; other site 694427005046 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 694427005047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427005048 active site 694427005049 Restriction endonuclease; Region: Mrr_cat; cl00516 694427005050 hypothetical protein; Provisional; Region: PRK12705 694427005051 RmuC family; Region: RmuC; pfam02646 694427005052 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 694427005053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 694427005054 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 694427005055 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 694427005056 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694427005057 FMN binding site [chemical binding]; other site 694427005058 active site 694427005059 catalytic residues [active] 694427005060 substrate binding site [chemical binding]; other site 694427005061 LytTr DNA-binding domain; Region: LytTR; cl04498 694427005062 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 694427005063 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 694427005064 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 694427005065 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 694427005066 hypothetical protein; Provisional; Region: PRK08185 694427005067 intersubunit interface [polypeptide binding]; other site 694427005068 active site 694427005069 zinc binding site [ion binding]; other site 694427005070 Na+ binding site [ion binding]; other site 694427005071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427005072 Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946 694427005073 NodB motif; other site 694427005074 putative active site [active] 694427005075 putative catalytic site [active] 694427005076 putative Zn binding site [ion binding]; other site 694427005077 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 694427005078 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 694427005079 active site 694427005080 intersubunit interface [polypeptide binding]; other site 694427005081 zinc binding site [ion binding]; other site 694427005082 Na+ binding site [ion binding]; other site 694427005083 Uncharacterized conserved protein [Function unknown]; Region: COG1624 694427005084 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 694427005085 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 694427005086 dihydropteroate synthase; Region: DHPS; TIGR01496 694427005087 substrate binding pocket [chemical binding]; other site 694427005088 dimer interface [polypeptide binding]; other site 694427005089 inhibitor binding site; inhibition site 694427005090 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 694427005091 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 694427005092 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 694427005093 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 694427005094 putative dimer interface [polypeptide binding]; other site 694427005095 putative anticodon binding site; other site 694427005096 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 694427005097 homodimer interface [polypeptide binding]; other site 694427005098 motif 1; other site 694427005099 motif 2; other site 694427005100 active site 694427005101 motif 3; other site 694427005102 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 694427005103 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 694427005104 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 694427005105 dimer interface [polypeptide binding]; other site 694427005106 PYR/PP interface [polypeptide binding]; other site 694427005107 TPP binding site [chemical binding]; other site 694427005108 substrate binding site [chemical binding]; other site 694427005109 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 694427005110 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 694427005111 TPP-binding site [chemical binding]; other site 694427005112 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427005113 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427005114 catalytic residues [active] 694427005115 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 694427005116 putative active site [active] 694427005117 dimerization interface [polypeptide binding]; other site 694427005118 putative tRNAtyr binding site [nucleotide binding]; other site 694427005119 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 694427005120 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 694427005121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427005122 Walker A/P-loop; other site 694427005123 ATP binding site [chemical binding]; other site 694427005124 Q-loop/lid; other site 694427005125 ABC transporter signature motif; other site 694427005126 Walker B; other site 694427005127 D-loop; other site 694427005128 H-loop/switch region; other site 694427005129 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 694427005130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427005131 Walker A motif; other site 694427005132 ATP binding site [chemical binding]; other site 694427005133 Walker B motif; other site 694427005134 arginine finger; other site 694427005135 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 694427005136 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 694427005137 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427005138 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427005139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427005140 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 694427005141 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694427005142 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694427005143 putative active site [active] 694427005144 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 694427005145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427005146 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 694427005147 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 694427005148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427005149 active site 694427005150 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427005151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427005152 active site 694427005153 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 694427005154 putative metal binding site; other site 694427005155 O-Antigen ligase; Region: Wzy_C; cl04850 694427005156 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 694427005157 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 694427005158 active site 694427005159 RNA/DNA hybrid binding site [nucleotide binding]; other site 694427005160 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 694427005161 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 694427005162 putative active site [active] 694427005163 putative metal binding site [ion binding]; other site 694427005164 Virulence protein [General function prediction only]; Region: COG3943 694427005165 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 694427005166 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 694427005167 HsdM N-terminal domain; Region: HsdM_N; pfam12161 694427005168 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 694427005169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005171 AAA domain; Region: AAA_13; pfam13166 694427005172 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 694427005173 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427005174 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427005175 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 694427005176 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 694427005177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427005178 ATP binding site [chemical binding]; other site 694427005179 putative Mg++ binding site [ion binding]; other site 694427005180 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 694427005181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427005182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005183 dimer interface [polypeptide binding]; other site 694427005184 phosphorylation site [posttranslational modification] 694427005185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005186 ATP binding site [chemical binding]; other site 694427005187 Mg2+ binding site [ion binding]; other site 694427005188 G-X-G motif; other site 694427005189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427005190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005191 ATP binding site [chemical binding]; other site 694427005192 Mg2+ binding site [ion binding]; other site 694427005193 G-X-G motif; other site 694427005194 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005196 active site 694427005197 phosphorylation site [posttranslational modification] 694427005198 intermolecular recognition site; other site 694427005199 dimerization interface [polypeptide binding]; other site 694427005200 Helix-turn-helix domains; Region: HTH; cl00088 694427005201 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 694427005202 Phage Tail Collar Domain; Region: Collar; pfam07484 694427005203 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427005204 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427005205 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 694427005206 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427005207 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005208 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427005209 ligand binding site [chemical binding]; other site 694427005210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427005211 active site 694427005212 Int/Topo IB signature motif; other site 694427005213 DNA binding site [nucleotide binding] 694427005214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427005215 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 694427005216 Walker A/P-loop; other site 694427005217 ATP binding site [chemical binding]; other site 694427005218 Q-loop/lid; other site 694427005219 ABC transporter signature motif; other site 694427005220 Walker B; other site 694427005221 D-loop; other site 694427005222 H-loop/switch region; other site 694427005223 Protein of unknown function DUF45; Region: DUF45; cl00636 694427005224 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 694427005225 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 694427005226 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 694427005227 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 694427005228 putative FMN binding site [chemical binding]; other site 694427005229 NADPH bind site [chemical binding]; other site 694427005230 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 694427005231 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 694427005232 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 694427005233 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 694427005234 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 694427005235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427005236 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 694427005237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005238 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 694427005239 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 694427005240 dinuclear metal binding motif [ion binding]; other site 694427005241 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 694427005242 TPR repeat; Region: TPR_11; pfam13414 694427005243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005244 binding surface 694427005245 TPR motif; other site 694427005246 TPR repeat; Region: TPR_11; pfam13414 694427005247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005248 binding surface 694427005249 TPR repeat; Region: TPR_11; pfam13414 694427005250 TPR motif; other site 694427005251 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005253 binding surface 694427005254 TPR motif; other site 694427005255 TPR repeat; Region: TPR_11; pfam13414 694427005256 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 694427005257 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 694427005258 Protein export membrane protein; Region: SecD_SecF; cl14618 694427005259 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 694427005260 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 694427005261 Protein export membrane protein; Region: SecD_SecF; cl14618 694427005262 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427005263 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 694427005264 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 694427005265 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427005266 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427005267 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427005268 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427005269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 694427005270 Putative glucoamylase; Region: Glycoamylase; pfam10091 694427005271 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427005272 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005273 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427005274 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427005275 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005276 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 694427005277 active site 694427005278 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 694427005279 sugar binding site [chemical binding]; other site 694427005280 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 694427005281 Interdomain contacts; other site 694427005282 Cytokine receptor motif; other site 694427005283 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005284 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427005285 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427005286 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427005287 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005288 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427005289 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427005290 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427005291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 694427005292 Putative glucoamylase; Region: Glycoamylase; pfam10091 694427005293 OpgC protein; Region: OpgC_C; cl00792 694427005294 Acyltransferase family; Region: Acyl_transf_3; pfam01757 694427005295 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427005296 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005297 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427005298 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427005299 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427005300 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427005301 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427005302 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 694427005303 AMP-binding enzyme; Region: AMP-binding; cl15778 694427005304 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 694427005305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427005306 non-specific DNA binding site [nucleotide binding]; other site 694427005307 salt bridge; other site 694427005308 sequence-specific DNA binding site [nucleotide binding]; other site 694427005309 Cupin domain; Region: Cupin_2; cl09118 694427005310 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 694427005311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005312 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005313 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 694427005314 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 694427005315 active site 694427005316 Int/Topo IB signature motif; other site 694427005317 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 694427005318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427005319 S-adenosylmethionine binding site [chemical binding]; other site 694427005320 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 694427005321 active site 694427005322 FMN binding site [chemical binding]; other site 694427005323 substrate binding site [chemical binding]; other site 694427005324 homotetramer interface [polypeptide binding]; other site 694427005325 catalytic residue [active] 694427005326 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 694427005327 trimer interface [polypeptide binding]; other site 694427005328 active site 694427005329 TPR repeat; Region: TPR_11; pfam13414 694427005330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005331 binding surface 694427005332 TPR motif; other site 694427005333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005334 binding surface 694427005335 TPR motif; other site 694427005336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005337 binding surface 694427005338 TPR motif; other site 694427005339 TPR repeat; Region: TPR_11; pfam13414 694427005340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005341 binding surface 694427005342 TPR motif; other site 694427005343 TPR repeat; Region: TPR_11; pfam13414 694427005344 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 694427005345 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 694427005346 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427005347 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 694427005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 694427005349 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 694427005350 ATP binding site [chemical binding]; other site 694427005351 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 694427005352 active site 694427005353 putative metal-binding site [ion binding]; other site 694427005354 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 694427005355 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 694427005356 nucleoside/Zn binding site; other site 694427005357 dimer interface [polypeptide binding]; other site 694427005358 catalytic motif [active] 694427005359 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 694427005360 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427005361 putative active site [active] 694427005362 putative metal binding site [ion binding]; other site 694427005363 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 694427005364 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 694427005365 active site 694427005366 nucleophile elbow; other site 694427005367 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 694427005368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 694427005369 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 694427005370 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 694427005371 putative active site [active] 694427005372 putative metal binding site [ion binding]; other site 694427005373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427005374 S-adenosylmethionine binding site [chemical binding]; other site 694427005375 Uncharacterized conserved protein [Function unknown]; Region: COG2433 694427005376 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 694427005377 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 694427005378 Zn binding sites [ion binding]; other site 694427005379 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 694427005380 catalytic motif [active] 694427005381 Catalytic residue [active] 694427005382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427005383 active site 694427005384 Peptidase family M48; Region: Peptidase_M48; cl12018 694427005385 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 694427005386 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 694427005387 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 694427005388 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 694427005389 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 694427005390 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 694427005391 purine monophosphate binding site [chemical binding]; other site 694427005392 dimer interface [polypeptide binding]; other site 694427005393 putative catalytic residues [active] 694427005394 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 694427005395 rod shape-determining protein MreB; Provisional; Region: PRK13927 694427005396 Cell division protein FtsA; Region: FtsA; cl11496 694427005397 rod shape-determining protein MreC; Provisional; Region: PRK13922 694427005398 rod shape-determining protein MreC; Region: MreC; pfam04085 694427005399 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 694427005400 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 694427005401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 694427005402 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 694427005403 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 694427005404 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 694427005405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694427005406 Acetokinase family; Region: Acetate_kinase; cl01029 694427005407 propionate/acetate kinase; Provisional; Region: PRK12379 694427005408 Acetokinase family; Region: Acetate_kinase; cl01029 694427005409 propionate/acetate kinase; Provisional; Region: PRK12379 694427005410 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 694427005411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005412 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 694427005413 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 694427005414 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 694427005415 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427005416 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 694427005417 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 694427005418 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 694427005419 substrate binding pocket [chemical binding]; other site 694427005420 chain length determination region; other site 694427005421 substrate-Mg2+ binding site; other site 694427005422 catalytic residues [active] 694427005423 aspartate-rich region 1; other site 694427005424 active site lid residues [active] 694427005425 aspartate-rich region 2; other site 694427005426 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 694427005427 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 694427005428 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427005429 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694427005430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427005431 RNA binding surface [nucleotide binding]; other site 694427005432 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 694427005433 active site 694427005434 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 694427005435 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 694427005436 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 694427005437 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005438 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 694427005439 catalytic motif [active] 694427005440 Catalytic residue [active] 694427005441 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 694427005442 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 694427005443 protein binding site [polypeptide binding]; other site 694427005444 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 694427005445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005446 NAD(P) binding site [chemical binding]; other site 694427005447 active site 694427005448 short chain dehydrogenase; Validated; Region: PRK06182 694427005449 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 694427005450 NADP binding site [chemical binding]; other site 694427005451 active site 694427005452 steroid binding site; other site 694427005453 Quinolinate synthetase A protein; Region: NadA; cl00420 694427005454 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427005455 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 694427005456 Peptidase family U32; Region: Peptidase_U32; cl03113 694427005457 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 694427005458 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694427005459 FMN binding site [chemical binding]; other site 694427005460 active site 694427005461 catalytic residues [active] 694427005462 substrate binding site [chemical binding]; other site 694427005463 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 694427005464 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 694427005465 active site 694427005466 Zn binding site [ion binding]; other site 694427005467 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 694427005468 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 694427005469 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 694427005470 GIY-YIG motif/motif A; other site 694427005471 active site 694427005472 catalytic site [active] 694427005473 putative DNA binding site [nucleotide binding]; other site 694427005474 metal binding site [ion binding]; metal-binding site 694427005475 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 694427005476 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 694427005477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005478 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 694427005479 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 694427005480 Uncharacterized conserved protein [Function unknown]; Region: COG3410 694427005481 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427005482 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 694427005483 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 694427005484 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 694427005485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005486 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 694427005487 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005488 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005489 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005490 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005491 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005492 Lamin Tail Domain; Region: LTD; pfam00932 694427005493 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005494 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005495 Bacterial Ig-like domain; Region: Big_5; cl01012 694427005496 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427005497 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694427005498 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 694427005499 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694427005500 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 694427005501 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 694427005502 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694427005503 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 694427005504 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 694427005505 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 694427005506 Helix-turn-helix domains; Region: HTH; cl00088 694427005507 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 694427005508 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 694427005509 active site 694427005510 HIGH motif; other site 694427005511 dimer interface [polypeptide binding]; other site 694427005512 KMSKS motif; other site 694427005513 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 694427005514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427005515 motif II; other site 694427005516 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 694427005517 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 694427005518 Predicted esterase [General function prediction only]; Region: COG0627 694427005519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427005520 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 694427005521 active site 694427005522 substrate-binding site [chemical binding]; other site 694427005523 metal-binding site [ion binding] 694427005524 ATP binding site [chemical binding]; other site 694427005525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427005526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427005527 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 694427005528 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 694427005529 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427005530 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005531 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427005532 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427005533 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427005534 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427005535 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427005536 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427005537 active site 694427005538 catalytic site [active] 694427005539 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005540 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427005541 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427005542 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427005543 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427005544 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427005545 Two component regulator propeller; Region: Reg_prop; pfam07494 694427005546 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427005547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005548 dimer interface [polypeptide binding]; other site 694427005549 phosphorylation site [posttranslational modification] 694427005550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005551 ATP binding site [chemical binding]; other site 694427005552 Mg2+ binding site [ion binding]; other site 694427005553 G-X-G motif; other site 694427005554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005555 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005556 active site 694427005557 phosphorylation site [posttranslational modification] 694427005558 intermolecular recognition site; other site 694427005559 dimerization interface [polypeptide binding]; other site 694427005560 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427005561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427005562 Two component regulator propeller; Region: Reg_prop; pfam07494 694427005563 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427005564 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427005565 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427005566 PA14 domain; Region: PA14; cl08459 694427005567 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 694427005568 putative active site [active] 694427005569 putative catalytic site [active] 694427005570 H+ Antiporter protein; Region: 2A0121; TIGR00900 694427005571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427005572 putative substrate translocation pore; other site 694427005573 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427005574 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 694427005575 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 694427005576 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 694427005577 Phage Tail Collar Domain; Region: Collar; pfam07484 694427005578 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 694427005579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427005580 FeS/SAM binding site; other site 694427005581 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 694427005582 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427005583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427005584 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427005585 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427005586 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 694427005587 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005588 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 694427005589 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694427005590 active site 694427005591 catalytic residues [active] 694427005592 galactokinase; Provisional; Region: PRK05322 694427005593 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 694427005594 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 694427005595 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694427005596 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 694427005597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427005598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427005599 DNA binding residues [nucleotide binding] 694427005600 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 694427005601 Uncharacterized conserved protein [Function unknown]; Region: COG2966 694427005602 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 694427005603 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 694427005604 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694427005605 metal-binding site [ion binding] 694427005606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 694427005607 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 694427005608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694427005609 metal-binding site [ion binding] 694427005610 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 694427005611 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 694427005612 active site 694427005613 Zn binding site [ion binding]; other site 694427005614 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 694427005615 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 694427005616 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 694427005617 tandem repeat interface [polypeptide binding]; other site 694427005618 oligomer interface [polypeptide binding]; other site 694427005619 active site residues [active] 694427005620 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 694427005621 tandem repeat interface [polypeptide binding]; other site 694427005622 oligomer interface [polypeptide binding]; other site 694427005623 active site residues [active] 694427005624 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 694427005625 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 694427005626 putative dimer interface [polypeptide binding]; other site 694427005627 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 694427005628 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 694427005629 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427005630 AMP-binding enzyme; Region: AMP-binding; cl15778 694427005631 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 694427005632 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 694427005633 dimerization interface [polypeptide binding]; other site 694427005634 active site 694427005635 metal binding site [ion binding]; metal-binding site 694427005636 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 694427005637 dsRNA binding site [nucleotide binding]; other site 694427005638 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 694427005639 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 694427005640 dimer interface [polypeptide binding]; other site 694427005641 active site 694427005642 Phosphopantetheine attachment site; Region: PP-binding; cl09936 694427005643 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 694427005644 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 694427005645 active site 694427005646 substrate binding site [chemical binding]; other site 694427005647 cosubstrate binding site; other site 694427005648 catalytic site [active] 694427005649 GTP-binding protein YchF; Reviewed; Region: PRK09601 694427005650 YchF GTPase; Region: YchF; cd01900 694427005651 G1 box; other site 694427005652 GTP/Mg2+ binding site [chemical binding]; other site 694427005653 Switch I region; other site 694427005654 G2 box; other site 694427005655 Switch II region; other site 694427005656 G3 box; other site 694427005657 G4 box; other site 694427005658 G5 box; other site 694427005659 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 694427005660 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427005661 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427005662 FecR protein; Region: FecR; pfam04773 694427005663 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427005664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427005665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427005666 DNA binding residues [nucleotide binding] 694427005667 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005669 active site 694427005670 phosphorylation site [posttranslational modification] 694427005671 intermolecular recognition site; other site 694427005672 dimerization interface [polypeptide binding]; other site 694427005673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427005674 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 694427005675 Walker A motif; other site 694427005676 ATP binding site [chemical binding]; other site 694427005677 Walker B motif; other site 694427005678 arginine finger; other site 694427005679 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 694427005680 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 694427005681 ATP-grasp domain; Region: ATP-grasp_4; cl03087 694427005682 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 694427005683 PAS fold; Region: PAS_4; pfam08448 694427005684 PAS domain S-box; Region: sensory_box; TIGR00229 694427005685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427005686 PAS domain S-box; Region: sensory_box; TIGR00229 694427005687 PAS domain S-box; Region: sensory_box; TIGR00229 694427005688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005689 putative active site [active] 694427005690 heme pocket [chemical binding]; other site 694427005691 PAS domain S-box; Region: sensory_box; TIGR00229 694427005692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427005693 PAS domain S-box; Region: sensory_box; TIGR00229 694427005694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005695 putative active site [active] 694427005696 heme pocket [chemical binding]; other site 694427005697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427005698 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 694427005699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005700 dimer interface [polypeptide binding]; other site 694427005701 phosphorylation site [posttranslational modification] 694427005702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005703 ATP binding site [chemical binding]; other site 694427005704 Mg2+ binding site [ion binding]; other site 694427005705 G-X-G motif; other site 694427005706 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005708 active site 694427005709 phosphorylation site [posttranslational modification] 694427005710 intermolecular recognition site; other site 694427005711 dimerization interface [polypeptide binding]; other site 694427005712 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005714 active site 694427005715 phosphorylation site [posttranslational modification] 694427005716 intermolecular recognition site; other site 694427005717 dimerization interface [polypeptide binding]; other site 694427005718 PAS domain S-box; Region: sensory_box; TIGR00229 694427005719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005720 putative active site [active] 694427005721 heme pocket [chemical binding]; other site 694427005722 PAS domain S-box; Region: sensory_box; TIGR00229 694427005723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005724 putative active site [active] 694427005725 heme pocket [chemical binding]; other site 694427005726 PAS domain S-box; Region: sensory_box; TIGR00229 694427005727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005728 putative active site [active] 694427005729 heme pocket [chemical binding]; other site 694427005730 PAS domain S-box; Region: sensory_box; TIGR00229 694427005731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005732 putative active site [active] 694427005733 heme pocket [chemical binding]; other site 694427005734 PAS domain S-box; Region: sensory_box; TIGR00229 694427005735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427005736 PAS domain S-box; Region: sensory_box; TIGR00229 694427005737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005738 putative active site [active] 694427005739 heme pocket [chemical binding]; other site 694427005740 PAS domain S-box; Region: sensory_box; TIGR00229 694427005741 PAS domain S-box; Region: sensory_box; TIGR00229 694427005742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005743 putative active site [active] 694427005744 heme pocket [chemical binding]; other site 694427005745 PAS domain S-box; Region: sensory_box; TIGR00229 694427005746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005747 putative active site [active] 694427005748 heme pocket [chemical binding]; other site 694427005749 PAS domain S-box; Region: sensory_box; TIGR00229 694427005750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427005751 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 694427005752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005753 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 694427005754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 694427005755 dimerization interface [polypeptide binding]; other site 694427005756 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 694427005757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005758 dimer interface [polypeptide binding]; other site 694427005759 phosphorylation site [posttranslational modification] 694427005760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005761 ATP binding site [chemical binding]; other site 694427005762 Mg2+ binding site [ion binding]; other site 694427005763 G-X-G motif; other site 694427005764 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005766 active site 694427005767 phosphorylation site [posttranslational modification] 694427005768 intermolecular recognition site; other site 694427005769 dimerization interface [polypeptide binding]; other site 694427005770 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005772 active site 694427005773 phosphorylation site [posttranslational modification] 694427005774 intermolecular recognition site; other site 694427005775 dimerization interface [polypeptide binding]; other site 694427005776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005777 active site 694427005778 phosphorylation site [posttranslational modification] 694427005779 intermolecular recognition site; other site 694427005780 dimerization interface [polypeptide binding]; other site 694427005781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005782 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005783 putative active site [active] 694427005784 heme pocket [chemical binding]; other site 694427005785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005786 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005787 putative active site [active] 694427005788 heme pocket [chemical binding]; other site 694427005789 GAF domain; Region: GAF_2; pfam13185 694427005790 GAF domain; Region: GAF; cl15785 694427005791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427005792 PAS domain S-box; Region: sensory_box; TIGR00229 694427005793 hypothetical protein; Provisional; Region: PRK13560 694427005794 Histidine kinase; Region: HisKA_3; pfam07730 694427005795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005796 ATP binding site [chemical binding]; other site 694427005797 Mg2+ binding site [ion binding]; other site 694427005798 G-X-G motif; other site 694427005799 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 694427005800 Sensory domain found in PocR; Region: PocR; pfam10114 694427005801 putative diguanylate cyclase; Provisional; Region: PRK09776 694427005802 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 694427005803 PAS fold; Region: PAS_3; pfam08447 694427005804 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 694427005805 PAS domain S-box; Region: sensory_box; TIGR00229 694427005806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005807 putative active site [active] 694427005808 heme pocket [chemical binding]; other site 694427005809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427005810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005811 ATP binding site [chemical binding]; other site 694427005812 Mg2+ binding site [ion binding]; other site 694427005813 G-X-G motif; other site 694427005814 response regulator; Provisional; Region: PRK09483 694427005815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005816 active site 694427005817 phosphorylation site [posttranslational modification] 694427005818 intermolecular recognition site; other site 694427005819 dimerization interface [polypeptide binding]; other site 694427005820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427005821 DNA binding residues [nucleotide binding] 694427005822 dimerization interface [polypeptide binding]; other site 694427005823 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427005824 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 694427005825 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 694427005826 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 694427005827 active site 694427005828 acetylornithine aminotransferase; Provisional; Region: PRK02627 694427005829 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694427005830 inhibitor-cofactor binding pocket; inhibition site 694427005831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427005832 catalytic residue [active] 694427005833 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 694427005834 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 694427005835 putative NADP binding site [chemical binding]; other site 694427005836 putative substrate binding site [chemical binding]; other site 694427005837 active site 694427005838 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 694427005839 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 694427005840 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 694427005841 active site 694427005842 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 694427005843 Ribonuclease P; Region: Ribonuclease_P; cl00457 694427005844 Haemolytic domain; Region: Haemolytic; cl00506 694427005845 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 694427005846 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 694427005847 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 694427005848 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 694427005849 DNA polymerase II small subunit; Validated; Region: PRK04036 694427005850 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 694427005851 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 694427005852 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 694427005853 Walker A/P-loop; other site 694427005854 ATP binding site [chemical binding]; other site 694427005855 Q-loop/lid; other site 694427005856 ABC transporter signature motif; other site 694427005857 Walker B; other site 694427005858 D-loop; other site 694427005859 H-loop/switch region; other site 694427005860 adenylosuccinate lyase; Provisional; Region: PRK09285 694427005861 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 694427005862 tetramer interface [polypeptide binding]; other site 694427005863 active site 694427005864 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 694427005865 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 694427005866 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 694427005867 intersubunit interface [polypeptide binding]; other site 694427005868 active site 694427005869 catalytic residue [active] 694427005870 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 694427005871 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 694427005872 substrate binding pocket [chemical binding]; other site 694427005873 chain length determination region; other site 694427005874 substrate-Mg2+ binding site; other site 694427005875 catalytic residues [active] 694427005876 aspartate-rich region 1; other site 694427005877 active site lid residues [active] 694427005878 aspartate-rich region 2; other site 694427005879 DNA polymerase I; Provisional; Region: PRK05755 694427005880 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 694427005881 active site 694427005882 metal binding site 1 [ion binding]; metal-binding site 694427005883 putative 5' ssDNA interaction site; other site 694427005884 metal binding site 3; metal-binding site 694427005885 metal binding site 2 [ion binding]; metal-binding site 694427005886 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 694427005887 putative DNA binding site [nucleotide binding]; other site 694427005888 putative metal binding site [ion binding]; other site 694427005889 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 694427005890 active site 694427005891 catalytic site [active] 694427005892 substrate binding site [chemical binding]; other site 694427005893 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 694427005894 active site 694427005895 DNA binding site [nucleotide binding] 694427005896 catalytic site [active] 694427005897 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 694427005898 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 694427005899 Helix-turn-helix domains; Region: HTH; cl00088 694427005900 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 694427005901 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 694427005902 Recombination protein O N terminal; Region: RecO_N; cl15812 694427005903 Recombination protein O C terminal; Region: RecO_C; pfam02565 694427005904 NlpC/P60 family; Region: NLPC_P60; cl11438 694427005905 autolysin; Reviewed; Region: PRK06347 694427005906 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 694427005907 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427005908 putative peptidoglycan binding site; other site 694427005909 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427005910 putative peptidoglycan binding site; other site 694427005911 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694427005912 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427005913 putative peptidoglycan binding site; other site 694427005914 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427005915 putative peptidoglycan binding site; other site 694427005916 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 694427005917 dimer interface [polypeptide binding]; other site 694427005918 catalytic triad [active] 694427005919 hypothetical protein; Reviewed; Region: PRK00024 694427005920 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 694427005921 MPN+ (JAMM) motif; other site 694427005922 Zinc-binding site [ion binding]; other site 694427005923 Superfamily II helicase [General function prediction only]; Region: COG1204 694427005924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427005925 ATP binding site [chemical binding]; other site 694427005926 putative Mg++ binding site [ion binding]; other site 694427005927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427005928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427005929 Coenzyme A binding pocket [chemical binding]; other site 694427005930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427005931 Coenzyme A binding pocket [chemical binding]; other site 694427005932 Integral membrane protein TerC family; Region: TerC; cl10468 694427005933 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 694427005934 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 694427005935 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 694427005936 trimer interface [polypeptide binding]; other site 694427005937 active site 694427005938 G bulge; other site 694427005939 thiamine-monophosphate kinase; Region: thiL; TIGR01379 694427005940 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 694427005941 ATP binding site [chemical binding]; other site 694427005942 dimerization interface [polypeptide binding]; other site 694427005943 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 694427005944 potential frameshift: common BLAST hit: gi|213693059|ref|YP_002323645.1| protein of unknown function DUF404 694427005945 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 694427005946 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 694427005947 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 694427005948 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 694427005949 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 694427005950 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 694427005951 active site 694427005952 Zn binding site [ion binding]; other site 694427005953 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 694427005954 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 694427005955 putative active site [active] 694427005956 Zn binding site [ion binding]; other site 694427005957 DinB superfamily; Region: DinB_2; pfam12867 694427005958 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 694427005959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427005960 S-adenosylmethionine binding site [chemical binding]; other site 694427005961 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427005962 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427005963 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 694427005964 peptide chain release factor 2; Validated; Region: prfB; PRK00578 694427005965 RF-1 domain; Region: RF-1; cl02875 694427005966 RF-1 domain; Region: RF-1; cl02875 694427005967 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 694427005968 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 694427005969 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 694427005970 DNA primase, catalytic core; Region: dnaG; TIGR01391 694427005971 CHC2 zinc finger; Region: zf-CHC2; cl15369 694427005972 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 694427005973 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 694427005974 active site 694427005975 metal binding site [ion binding]; metal-binding site 694427005976 interdomain interaction site; other site 694427005977 Radical SAM superfamily; Region: Radical_SAM; pfam04055 694427005978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427005979 FeS/SAM binding site; other site 694427005980 conserved hypothetical protein; Region: MJ1255; TIGR00661 694427005981 4Fe-4S binding domain; Region: Fer4; cl02805 694427005982 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 694427005983 4Fe-4S binding domain; Region: Fer4; cl02805 694427005984 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427005985 Colicin V production protein; Region: Colicin_V; cl00567 694427005986 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 694427005987 RNA/DNA hybrid binding site [nucleotide binding]; other site 694427005988 active site 694427005989 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 694427005990 Surface antigen; Region: Bac_surface_Ag; cl03097 694427005991 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 694427005992 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 694427005993 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427005994 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427005995 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427005996 pyruvate kinase; Provisional; Region: PRK05826 694427005997 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 694427005998 domain interfaces; other site 694427005999 active site 694427006000 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 694427006001 trimer interface [polypeptide binding]; other site 694427006002 active site 694427006003 dimer interface [polypeptide binding]; other site 694427006004 PQ loop repeat; Region: PQ-loop; cl12056 694427006005 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 694427006006 putative catalytic site [active] 694427006007 putative metal binding site [ion binding]; other site 694427006008 putative phosphate binding site [ion binding]; other site 694427006009 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 694427006010 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 694427006011 ligand binding site [chemical binding]; other site 694427006012 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 694427006013 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 694427006014 MoxR-like ATPases [General function prediction only]; Region: COG0714 694427006015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427006016 Walker A motif; other site 694427006017 ATP binding site [chemical binding]; other site 694427006018 Walker B motif; other site 694427006019 arginine finger; other site 694427006020 Putative sensor; Region: Sensor; pfam13796 694427006021 Integral membrane protein DUF95; Region: DUF95; cl00572 694427006022 RDD family; Region: RDD; cl00746 694427006023 ribonuclease R; Region: RNase_R; TIGR02063 694427006024 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 694427006025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006026 active site 694427006027 catalytic tetrad [active] 694427006028 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 694427006029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006030 active site 694427006031 catalytic tetrad [active] 694427006032 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 694427006033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427006034 active site 694427006035 metal binding site [ion binding]; metal-binding site 694427006036 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 694427006037 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 694427006038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427006039 putative substrate translocation pore; other site 694427006040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427006041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427006042 Sulfatase; Region: Sulfatase; cl10460 694427006043 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 694427006044 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 694427006045 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 694427006046 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 694427006047 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 694427006048 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 694427006049 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 694427006050 putative active site [active] 694427006051 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 694427006052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427006053 motif II; other site 694427006054 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 694427006055 tellurium resistance terB-like protein; Region: terB_like; cd07177 694427006056 metal binding site [ion binding]; metal-binding site 694427006057 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694427006058 HSP70 interaction site [polypeptide binding]; other site 694427006059 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 694427006060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427006061 active site 694427006062 HIGH motif; other site 694427006063 nucleotide binding site [chemical binding]; other site 694427006064 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 694427006065 KMSKS motif; other site 694427006066 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694427006067 tRNA binding surface [nucleotide binding]; other site 694427006068 anticodon binding site; other site 694427006069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006070 Ribosome-binding factor A; Region: RBFA; cl00542 694427006071 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 694427006072 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427006073 FtsX-like permease family; Region: FtsX; cl15850 694427006074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694427006075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427006076 DNA binding site [nucleotide binding] 694427006077 domain linker motif; other site 694427006078 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 694427006079 ligand binding site [chemical binding]; other site 694427006080 dimerization interface [polypeptide binding]; other site 694427006081 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 694427006082 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 694427006083 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 694427006084 putative NAD(P) binding site [chemical binding]; other site 694427006085 catalytic Zn binding site [ion binding]; other site 694427006086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427006088 active site 694427006089 catalytic tetrad [active] 694427006090 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 694427006091 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427006092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 694427006093 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 694427006094 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 694427006095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427006097 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 694427006098 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 694427006099 GIY-YIG motif/motif A; other site 694427006100 putative active site [active] 694427006101 putative metal binding site [ion binding]; other site 694427006102 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006103 von Willebrand factor; Region: vWF_A; pfam12450 694427006104 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 694427006105 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 694427006106 metal ion-dependent adhesion site (MIDAS); other site 694427006107 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 694427006108 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427006109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427006111 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006112 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 694427006113 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 694427006114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006115 AAA domain; Region: AAA_21; pfam13304 694427006116 Walker A/P-loop; other site 694427006117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006118 Walker B; other site 694427006119 D-loop; other site 694427006120 H-loop/switch region; other site 694427006121 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 694427006122 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 694427006123 putative active site [active] 694427006124 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427006125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427006126 Coenzyme A binding pocket [chemical binding]; other site 694427006127 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427006128 Active site serine [active] 694427006129 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427006130 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 694427006131 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427006132 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694427006133 putative active site [active] 694427006134 putative metal binding site [ion binding]; other site 694427006135 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427006136 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 694427006137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427006138 non-specific DNA binding site [nucleotide binding]; other site 694427006139 salt bridge; other site 694427006140 sequence-specific DNA binding site [nucleotide binding]; other site 694427006141 Tic20-like protein; Region: Tic20; pfam09685 694427006142 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 694427006143 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427006144 catalytic residues [active] 694427006145 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427006146 transaldolase-like protein; Provisional; Region: PTZ00411 694427006147 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 694427006148 active site 694427006149 dimer interface [polypeptide binding]; other site 694427006150 catalytic residue [active] 694427006151 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427006152 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427006153 SLBB domain; Region: SLBB; pfam10531 694427006154 Chain length determinant protein; Region: Wzz; cl15801 694427006155 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 694427006156 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 694427006157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006158 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694427006159 trimer interface [polypeptide binding]; other site 694427006160 active site 694427006161 substrate binding site [chemical binding]; other site 694427006162 CoA binding site [chemical binding]; other site 694427006163 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006165 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 694427006166 trimer interface [polypeptide binding]; other site 694427006167 active site 694427006168 substrate binding site [chemical binding]; other site 694427006169 CoA binding site [chemical binding]; other site 694427006170 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427006171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427006172 active site 694427006173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427006174 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 694427006175 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427006176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006177 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427006179 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 694427006180 active site 694427006181 ATP binding site [chemical binding]; other site 694427006182 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006183 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 694427006184 putative active site [active] 694427006185 putative metal binding site [ion binding]; other site 694427006186 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006187 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006188 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 694427006189 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 694427006190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006191 Bacterial sugar transferase; Region: Bac_transf; cl00939 694427006192 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006193 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006196 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006197 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006198 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006199 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427006200 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006201 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427006202 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 694427006204 adenylate kinase; Reviewed; Region: adk; PRK00279 694427006205 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 694427006206 AMP-binding site [chemical binding]; other site 694427006207 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 694427006208 GTPase CgtA; Reviewed; Region: obgE; PRK12299 694427006209 GTP1/OBG; Region: GTP1_OBG; pfam01018 694427006210 Obg GTPase; Region: Obg; cd01898 694427006211 G1 box; other site 694427006212 GTP/Mg2+ binding site [chemical binding]; other site 694427006213 Switch I region; other site 694427006214 G2 box; other site 694427006215 G3 box; other site 694427006216 Switch II region; other site 694427006217 G4 box; other site 694427006218 G5 box; other site 694427006219 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 694427006220 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 694427006221 B3/4 domain; Region: B3_4; cl11458 694427006222 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 694427006223 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 694427006224 Cl- selectivity filter; other site 694427006225 Cl- binding residues [ion binding]; other site 694427006226 pore gating glutamate residue; other site 694427006227 dimer interface [polypeptide binding]; other site 694427006228 FOG: CBS domain [General function prediction only]; Region: COG0517 694427006229 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 694427006230 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 694427006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006232 Bacterial sugar transferase; Region: Bac_transf; cl00939 694427006233 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 694427006234 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 694427006235 DHH family; Region: DHH; pfam01368 694427006236 DHHA1 domain; Region: DHHA1; pfam02272 694427006237 Domain of unknown function DUF20; Region: UPF0118; pfam01594 694427006238 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 694427006239 thymidine kinase; Provisional; Region: PRK04296 694427006240 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 694427006241 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 694427006242 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 694427006243 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 694427006244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427006245 motif II; other site 694427006246 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 694427006247 polycystin cation channel protein; Region: PCC; TIGR00864 694427006248 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427006249 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427006250 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427006251 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 694427006252 Predicted RNA interaction site [nucleotide binding]; other site 694427006253 putative binding site; other site 694427006254 Mutations affecting start-site selection; other site 694427006255 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 694427006256 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 694427006257 active site triad [active] 694427006258 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 694427006259 active site 694427006260 dimerization interface [polypeptide binding]; other site 694427006261 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427006262 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427006263 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427006264 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 694427006265 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 694427006266 catalytic motif [active] 694427006267 Catalytic residue [active] 694427006268 Kelch motif; Region: Kelch_1; cl02701 694427006269 cyclically-permuted mutatrotase family protein; Region: mutarot_permut; TIGR03548 694427006270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006271 binding surface 694427006272 TPR repeat; Region: TPR_11; pfam13414 694427006273 TPR motif; other site 694427006274 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 694427006275 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 694427006276 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 694427006277 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 694427006278 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 694427006279 homodecamer interface [polypeptide binding]; other site 694427006280 GTP cyclohydrolase I; Provisional; Region: PLN03044 694427006281 active site 694427006282 putative catalytic site residues [active] 694427006283 zinc binding site [ion binding]; other site 694427006284 GTP-CH-I/GFRP interaction surface; other site 694427006285 Sporulation related domain; Region: SPOR; cl10051 694427006286 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 694427006287 substrate binding site; other site 694427006288 dimer interface; other site 694427006289 OpgC protein; Region: OpgC_C; cl00792 694427006290 Acyltransferase family; Region: Acyl_transf_3; pfam01757 694427006291 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 694427006292 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 694427006293 generic binding surface II; other site 694427006294 ssDNA binding site; other site 694427006295 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427006296 ATP binding site [chemical binding]; other site 694427006297 putative Mg++ binding site [ion binding]; other site 694427006298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427006299 nucleotide binding region [chemical binding]; other site 694427006300 ATP-binding site [chemical binding]; other site 694427006301 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 694427006302 active site 694427006303 multimer interface [polypeptide binding]; other site 694427006304 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427006305 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 694427006306 putative peptidoglycan binding site; other site 694427006307 Adenosylhomocysteinase; Provisional; Region: PTZ00075 694427006308 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 694427006309 oligomerization interface [polypeptide binding]; other site 694427006310 active site 694427006311 NAD+ binding site [chemical binding]; other site 694427006312 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427006313 active site 694427006314 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427006315 C-terminal peptidase (prc); Region: prc; TIGR00225 694427006316 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694427006317 protein binding site [polypeptide binding]; other site 694427006318 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 694427006319 Catalytic dyad [active] 694427006320 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 694427006321 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 694427006322 active site 694427006323 AAA domain; Region: AAA_28; pfam13521 694427006324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006325 serine O-acetyltransferase; Region: cysE; TIGR01172 694427006326 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694427006327 trimer interface [polypeptide binding]; other site 694427006328 active site 694427006329 substrate binding site [chemical binding]; other site 694427006330 CoA binding site [chemical binding]; other site 694427006331 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 694427006332 THUMP domain; Region: THUMP; cl12076 694427006333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006334 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 694427006335 putative hydrophobic ligand binding site [chemical binding]; other site 694427006336 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006337 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427006338 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006339 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006340 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006341 GAF domain; Region: GAF; cl15785 694427006342 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427006343 AMP-binding enzyme; Region: AMP-binding; cl15778 694427006344 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427006345 ligand binding site [chemical binding]; other site 694427006346 Domain of unknown function DUF59; Region: DUF59; cl00941 694427006347 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 694427006348 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 694427006349 Walker A motif; other site 694427006350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 694427006351 GldH lipoprotein; Region: GldH_lipo; cl11905 694427006352 PSP1 C-terminal conserved region; Region: PSP1; cl00770 694427006353 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 694427006354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006355 NigD-like protein; Region: NigD; pfam12667 694427006356 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 694427006357 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 694427006358 metal binding site [ion binding]; metal-binding site 694427006359 dimer interface [polypeptide binding]; other site 694427006360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427006361 Helix-turn-helix domains; Region: HTH; cl00088 694427006362 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427006363 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694427006364 E3 interaction surface; other site 694427006365 lipoyl attachment site [posttranslational modification]; other site 694427006366 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427006367 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427006368 Protein export membrane protein; Region: SecD_SecF; cl14618 694427006369 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427006370 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427006371 Helix-turn-helix domains; Region: HTH; cl00088 694427006372 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 694427006373 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 694427006374 tetramer interfaces [polypeptide binding]; other site 694427006375 binuclear metal-binding site [ion binding]; other site 694427006376 GtrA-like protein; Region: GtrA; cl00971 694427006377 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006378 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 694427006379 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 694427006380 active site 694427006381 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 694427006382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 694427006383 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 694427006384 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 694427006385 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 694427006386 trimer interface [polypeptide binding]; other site 694427006387 active site 694427006388 UDP-GlcNAc binding site [chemical binding]; other site 694427006389 lipid binding site [chemical binding]; lipid-binding site 694427006390 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 694427006391 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 694427006392 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 694427006393 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 694427006394 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 694427006395 active site 694427006396 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 694427006397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427006398 active site 694427006399 HIGH motif; other site 694427006400 nucleotide binding site [chemical binding]; other site 694427006401 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 694427006402 KMSKS motif; other site 694427006403 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 694427006404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427006405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006406 active site 694427006407 phosphorylation site [posttranslational modification] 694427006408 intermolecular recognition site; other site 694427006409 dimerization interface [polypeptide binding]; other site 694427006410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427006411 DNA binding site [nucleotide binding] 694427006412 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 694427006413 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 694427006414 active site 694427006415 nucleophile elbow; other site 694427006416 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427006417 FMN binding site [chemical binding]; other site 694427006418 hypothetical protein; Provisional; Region: PRK14851 694427006419 dimer interface [polypeptide binding]; other site 694427006420 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427006421 ligand binding site [chemical binding]; other site 694427006422 flexible hinge region; other site 694427006423 DNA topoisomerase I; Validated; Region: PRK06599 694427006424 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 694427006425 active site 694427006426 interdomain interaction site; other site 694427006427 putative metal-binding site [ion binding]; other site 694427006428 nucleotide binding site [chemical binding]; other site 694427006429 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 694427006430 domain I; other site 694427006431 DNA binding groove [nucleotide binding] 694427006432 phosphate binding site [ion binding]; other site 694427006433 domain II; other site 694427006434 domain III; other site 694427006435 nucleotide binding site [chemical binding]; other site 694427006436 catalytic site [active] 694427006437 domain IV; other site 694427006438 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 694427006439 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 694427006440 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 694427006441 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 694427006442 ribonuclease R; Region: RNase_R; TIGR02063 694427006443 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427006444 RNB domain; Region: RNB; pfam00773 694427006445 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 694427006446 RNA binding site [nucleotide binding]; other site 694427006447 GTP-binding protein LepA; Provisional; Region: PRK05433 694427006448 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 694427006449 G1 box; other site 694427006450 putative GEF interaction site [polypeptide binding]; other site 694427006451 GTP/Mg2+ binding site [chemical binding]; other site 694427006452 Switch I region; other site 694427006453 G2 box; other site 694427006454 G3 box; other site 694427006455 Switch II region; other site 694427006456 G4 box; other site 694427006457 G5 box; other site 694427006458 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 694427006459 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 694427006460 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 694427006461 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 694427006462 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 694427006463 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 694427006464 alpha subunit interaction interface [polypeptide binding]; other site 694427006465 Walker A motif; other site 694427006466 ATP binding site [chemical binding]; other site 694427006467 Walker B motif; other site 694427006468 inhibitor binding site; inhibition site 694427006469 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 694427006470 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 694427006471 ATP synthase A chain; Region: ATP-synt_A; cl00413 694427006472 Plant ATP synthase F0; Region: YMF19; cl07975 694427006473 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 694427006474 Plant ATP synthase F0; Region: YMF19; cl07975 694427006475 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 694427006476 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 694427006477 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 694427006478 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 694427006479 beta subunit interaction interface [polypeptide binding]; other site 694427006480 Walker A motif; other site 694427006481 ATP binding site [chemical binding]; other site 694427006482 Walker B motif; other site 694427006483 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 694427006484 ATP synthase; Region: ATP-synt; cl00365 694427006485 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 694427006486 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006488 binding surface 694427006489 TPR motif; other site 694427006490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006492 binding surface 694427006493 TPR motif; other site 694427006494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006497 binding surface 694427006498 TPR motif; other site 694427006499 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006501 binding surface 694427006502 TPR motif; other site 694427006503 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006505 Histidine kinase; Region: His_kinase; pfam06580 694427006506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 694427006507 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427006508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006509 active site 694427006510 phosphorylation site [posttranslational modification] 694427006511 intermolecular recognition site; other site 694427006512 dimerization interface [polypeptide binding]; other site 694427006513 LytTr DNA-binding domain; Region: LytTR; cl04498 694427006514 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 694427006515 S17 interaction site [polypeptide binding]; other site 694427006516 S8 interaction site; other site 694427006517 16S rRNA interaction site [nucleotide binding]; other site 694427006518 streptomycin interaction site [chemical binding]; other site 694427006519 23S rRNA interaction site [nucleotide binding]; other site 694427006520 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 694427006521 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 694427006522 elongation factor G; Reviewed; Region: PRK12739 694427006523 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 694427006524 G1 box; other site 694427006525 putative GEF interaction site [polypeptide binding]; other site 694427006526 GTP/Mg2+ binding site [chemical binding]; other site 694427006527 Switch I region; other site 694427006528 G2 box; other site 694427006529 G3 box; other site 694427006530 Switch II region; other site 694427006531 G4 box; other site 694427006532 G5 box; other site 694427006533 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 694427006534 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 694427006535 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 694427006536 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 694427006537 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 694427006538 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 694427006539 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 694427006540 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 694427006541 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 694427006542 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 694427006543 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 694427006544 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 694427006545 putative translocon binding site; other site 694427006546 protein-rRNA interface [nucleotide binding]; other site 694427006547 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 694427006548 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 694427006549 G-X-X-G motif; other site 694427006550 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 694427006551 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 694427006552 23S rRNA interface [nucleotide binding]; other site 694427006553 5S rRNA interface [nucleotide binding]; other site 694427006554 putative antibiotic binding site [chemical binding]; other site 694427006555 L25 interface [polypeptide binding]; other site 694427006556 L27 interface [polypeptide binding]; other site 694427006557 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 694427006558 23S rRNA interface [nucleotide binding]; other site 694427006559 putative translocon interaction site; other site 694427006560 signal recognition particle (SRP54) interaction site; other site 694427006561 L23 interface [polypeptide binding]; other site 694427006562 trigger factor interaction site; other site 694427006563 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 694427006564 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 694427006565 KOW motif; Region: KOW; cl00354 694427006566 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 694427006567 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 694427006568 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 694427006569 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 694427006570 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 694427006571 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 694427006572 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 694427006573 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 694427006574 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 694427006575 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 694427006576 23S rRNA interface [nucleotide binding]; other site 694427006577 L21e interface [polypeptide binding]; other site 694427006578 5S rRNA interface [nucleotide binding]; other site 694427006579 L27 interface [polypeptide binding]; other site 694427006580 L5 interface [polypeptide binding]; other site 694427006581 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 694427006582 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 694427006583 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 694427006584 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 694427006585 23S rRNA binding site [nucleotide binding]; other site 694427006586 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 694427006587 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 694427006588 SecY translocase; Region: SecY; pfam00344 694427006589 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 694427006590 active site 694427006591 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 694427006592 rRNA binding site [nucleotide binding]; other site 694427006593 predicted 30S ribosome binding site; other site 694427006594 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 694427006595 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 694427006596 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 694427006597 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 694427006598 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 694427006599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427006600 RNA binding surface [nucleotide binding]; other site 694427006601 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 694427006602 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 694427006603 alphaNTD - beta interaction site [polypeptide binding]; other site 694427006604 alphaNTD homodimer interface [polypeptide binding]; other site 694427006605 alphaNTD - beta' interaction site [polypeptide binding]; other site 694427006606 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 694427006607 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 694427006608 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427006609 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 694427006610 putative nucleotide binding site [chemical binding]; other site 694427006611 uridine monophosphate binding site [chemical binding]; other site 694427006612 homohexameric interface [polypeptide binding]; other site 694427006613 ribosome recycling factor; Reviewed; Region: frr; PRK00083 694427006614 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 694427006615 hinge region; other site 694427006616 GTPase RsgA; Reviewed; Region: PRK00098 694427006617 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 694427006618 RNA binding site [nucleotide binding]; other site 694427006619 homodimer interface [polypeptide binding]; other site 694427006620 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 694427006621 GTPase/Zn-binding domain interface [polypeptide binding]; other site 694427006622 GTP/Mg2+ binding site [chemical binding]; other site 694427006623 G4 box; other site 694427006624 G5 box; other site 694427006625 G1 box; other site 694427006626 Switch I region; other site 694427006627 G2 box; other site 694427006628 G3 box; other site 694427006629 Switch II region; other site 694427006630 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 694427006631 Helix-turn-helix domains; Region: HTH; cl00088 694427006632 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 694427006633 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 694427006634 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 694427006635 KMSK motif region; other site 694427006636 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694427006637 tRNA binding surface [nucleotide binding]; other site 694427006638 anticodon binding site; other site 694427006639 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427006640 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 694427006641 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694427006642 catalytic residue [active] 694427006643 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 694427006644 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 694427006645 active site 694427006646 (T/H)XGH motif; other site 694427006647 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427006648 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694427006649 protein binding site [polypeptide binding]; other site 694427006650 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 694427006651 Catalytic dyad [active] 694427006652 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 694427006653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427006654 non-specific DNA binding site [nucleotide binding]; other site 694427006655 salt bridge; other site 694427006656 sequence-specific DNA binding site [nucleotide binding]; other site 694427006657 Cupin domain; Region: Cupin_2; cl09118 694427006658 AMP-binding domain protein; Validated; Region: PRK08315 694427006659 AMP-binding enzyme; Region: AMP-binding; cl15778 694427006660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 694427006661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006662 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 694427006663 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 694427006664 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427006665 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 694427006666 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 694427006667 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 694427006668 GldM N-terminal domain; Region: GldM_N; pfam12081 694427006669 GldM C-terminal domain; Region: GldM_C; pfam12080 694427006670 gliding motility associated protien GldN; Region: GldN; TIGR03523 694427006671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427006672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427006673 DNA binding residues [nucleotide binding] 694427006674 dimerization interface [polypeptide binding]; other site 694427006675 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 694427006676 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 694427006677 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427006678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006680 DNA binding residues [nucleotide binding] 694427006681 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427006682 FecR protein; Region: FecR; pfam04773 694427006683 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006684 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006685 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427006686 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006687 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006688 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427006689 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427006690 catalytic residues [active] 694427006691 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006692 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427006693 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006694 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006695 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006696 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427006697 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006698 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006699 DNA binding residues [nucleotide binding] 694427006700 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427006701 FecR protein; Region: FecR; pfam04773 694427006702 Secretin and TonB N terminus short domain; Region: STN; cl06624 694427006703 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006704 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006705 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427006706 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006707 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427006708 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427006709 catalytic residues [active] 694427006710 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 694427006711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694427006712 nucleophilic elbow; other site 694427006713 catalytic triad; other site 694427006714 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006715 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427006716 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006717 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006718 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006719 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427006720 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427006721 catalytic residues [active] 694427006722 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427006723 catalytic residues [active] 694427006724 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427006725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006727 DNA binding residues [nucleotide binding] 694427006728 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427006729 FecR protein; Region: FecR; pfam04773 694427006730 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006731 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006732 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427006733 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006734 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006735 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427006736 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427006737 catalytic residues [active] 694427006738 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 694427006739 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 694427006740 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 694427006741 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 694427006742 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 694427006743 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427006744 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 694427006745 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 694427006746 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 694427006747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427006748 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 694427006749 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 694427006750 active site residue [active] 694427006751 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694427006752 active site residue [active] 694427006753 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694427006754 active site residue [active] 694427006755 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427006756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006758 DNA binding residues [nucleotide binding] 694427006759 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 694427006760 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 694427006761 Active Sites [active] 694427006762 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 694427006763 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 694427006764 CysD dimerization site [polypeptide binding]; other site 694427006765 G1 box; other site 694427006766 putative GEF interaction site [polypeptide binding]; other site 694427006767 GTP/Mg2+ binding site [chemical binding]; other site 694427006768 Switch I region; other site 694427006769 G2 box; other site 694427006770 G3 box; other site 694427006771 Switch II region; other site 694427006772 G4 box; other site 694427006773 G5 box; other site 694427006774 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 694427006775 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 694427006776 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 694427006777 Active Sites [active] 694427006778 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 694427006779 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 694427006780 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 694427006781 FAD binding pocket [chemical binding]; other site 694427006782 FAD binding motif [chemical binding]; other site 694427006783 catalytic residues [active] 694427006784 NAD binding pocket [chemical binding]; other site 694427006785 phosphate binding motif [ion binding]; other site 694427006786 beta-alpha-beta structure motif; other site 694427006787 sulfite reductase subunit beta; Provisional; Region: PRK13504 694427006788 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427006789 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427006790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006791 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427006792 Two component regulator propeller; Region: Reg_prop; pfam07494 694427006793 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427006794 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 694427006795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427006796 dimer interface [polypeptide binding]; other site 694427006797 phosphorylation site [posttranslational modification] 694427006798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427006799 ATP binding site [chemical binding]; other site 694427006800 Mg2+ binding site [ion binding]; other site 694427006801 G-X-G motif; other site 694427006802 Response regulator receiver domain; Region: Response_reg; pfam00072 694427006803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006804 active site 694427006805 phosphorylation site [posttranslational modification] 694427006806 intermolecular recognition site; other site 694427006807 dimerization interface [polypeptide binding]; other site 694427006808 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427006809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427006810 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 694427006811 active site 694427006812 catalytic residues [active] 694427006813 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006814 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006815 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006816 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006817 starch binding outer membrane protein SusD; Region: SusD; cl15876 694427006818 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 694427006819 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427006820 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427006821 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427006822 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427006823 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427006824 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 694427006825 putative active site [active] 694427006826 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 694427006827 Cobalt transport protein component CbiN; Region: CbiN; cl00842 694427006828 Cobalt transport protein; Region: CbiQ; cl00463 694427006829 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 694427006830 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 694427006831 Walker A/P-loop; other site 694427006832 ATP binding site [chemical binding]; other site 694427006833 Q-loop/lid; other site 694427006834 ABC transporter signature motif; other site 694427006835 Walker B; other site 694427006836 D-loop; other site 694427006837 H-loop/switch region; other site 694427006838 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 694427006839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006840 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 694427006841 catalytic triad [active] 694427006842 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 694427006843 Precorrin-8X methylmutase; Region: CbiC; pfam02570 694427006844 CbiD; Region: CbiD; cl00828 694427006845 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 694427006846 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 694427006847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 694427006848 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 694427006849 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 694427006850 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 694427006851 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 694427006852 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 694427006853 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 694427006854 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 694427006855 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 694427006856 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 694427006857 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 694427006858 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 694427006859 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 694427006860 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 694427006861 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 694427006862 homodimer interface [polypeptide binding]; other site 694427006863 Walker A motif; other site 694427006864 ATP binding site [chemical binding]; other site 694427006865 hydroxycobalamin binding site [chemical binding]; other site 694427006866 Walker B motif; other site 694427006867 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 694427006868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006869 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 694427006870 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 694427006871 protoporphyrinogen oxidase; Region: PLN02576 694427006872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427006873 Ferrochelatase; Region: Ferrochelatase; pfam00762 694427006874 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 694427006875 C-terminal domain interface [polypeptide binding]; other site 694427006876 active site 694427006877 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 694427006878 active site 694427006879 N-terminal domain interface [polypeptide binding]; other site 694427006880 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 694427006881 HemN C-terminal domain; Region: HemN_C; pfam06969 694427006882 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 694427006883 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 694427006884 substrate binding site [chemical binding]; other site 694427006885 active site 694427006886 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 694427006887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694427006888 inhibitor-cofactor binding pocket; inhibition site 694427006889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427006890 catalytic residue [active] 694427006891 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 694427006892 dimer interface [polypeptide binding]; other site 694427006893 active site 694427006894 Schiff base residues; other site 694427006895 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 694427006896 active site 694427006897 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 694427006898 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 694427006899 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 694427006900 domain interfaces; other site 694427006901 active site 694427006902 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 694427006903 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 694427006904 tRNA; other site 694427006905 putative tRNA binding site [nucleotide binding]; other site 694427006906 putative NADP binding site [chemical binding]; other site 694427006907 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 694427006908 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 694427006909 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 694427006910 homodimer interface [polypeptide binding]; other site 694427006911 substrate-cofactor binding pocket; other site 694427006912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427006913 catalytic residue [active] 694427006914 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694427006915 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694427006916 dimer interface [polypeptide binding]; other site 694427006917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427006918 catalytic residue [active] 694427006919 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 694427006920 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 694427006921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427006922 Walker A/P-loop; other site 694427006923 ATP binding site [chemical binding]; other site 694427006924 Q-loop/lid; other site 694427006925 ABC transporter signature motif; other site 694427006926 Walker B; other site 694427006927 D-loop; other site 694427006928 H-loop/switch region; other site 694427006929 ABC transporter; Region: ABC_tran_2; pfam12848 694427006930 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427006931 KilA-N domain; Region: KilA-N; pfam04383 694427006932 Rubrerythrin [Energy production and conversion]; Region: COG1592 694427006933 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 694427006934 binuclear metal center [ion binding]; other site 694427006935 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 694427006936 iron binding site [ion binding]; other site 694427006937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 694427006938 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 694427006939 active site 694427006940 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 694427006941 16S/18S rRNA binding site [nucleotide binding]; other site 694427006942 S13e-L30e interaction site [polypeptide binding]; other site 694427006943 25S rRNA binding site [nucleotide binding]; other site 694427006944 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 694427006945 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 694427006946 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 694427006947 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 694427006948 dimer interface [polypeptide binding]; other site 694427006949 motif 1; other site 694427006950 active site 694427006951 motif 2; other site 694427006952 motif 3; other site 694427006953 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 694427006954 anticodon binding site; other site 694427006955 Protein of unknown function (DUF456); Region: DUF456; cl01069 694427006956 LytTr DNA-binding domain; Region: LytTR; cl04498 694427006957 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 694427006958 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 694427006959 active site 694427006960 nucleophile elbow; other site 694427006961 aspartate aminotransferase; Provisional; Region: PRK05764 694427006962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427006963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427006964 homodimer interface [polypeptide binding]; other site 694427006965 catalytic residue [active] 694427006966 HEPN domain; Region: HEPN; cl00824 694427006967 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 694427006968 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 694427006969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006970 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427006971 active site 694427006972 catalytic tetrad [active] 694427006973 PAS domain; Region: PAS_9; pfam13426 694427006974 Phosphoglycerate kinase; Region: PGK; pfam00162 694427006975 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 694427006976 substrate binding site [chemical binding]; other site 694427006977 hinge regions; other site 694427006978 ADP binding site [chemical binding]; other site 694427006979 catalytic site [active] 694427006980 malate dehydrogenase; Reviewed; Region: PRK06223 694427006981 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 694427006982 dimer interface [polypeptide binding]; other site 694427006983 NAD(P) binding site [chemical binding]; other site 694427006984 tetramer (dimer of dimers) interface [polypeptide binding]; other site 694427006985 substrate binding site [chemical binding]; other site 694427006986 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427006987 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427006988 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 694427006989 metal binding site 2 [ion binding]; metal-binding site 694427006990 putative DNA binding helix; other site 694427006991 metal binding site 1 [ion binding]; metal-binding site 694427006992 dimer interface [polypeptide binding]; other site 694427006993 structural Zn2+ binding site [ion binding]; other site 694427006994 Surface antigen; Region: Bac_surface_Ag; cl03097 694427006995 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427006996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427006997 active site 694427006998 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 694427006999 iron-sulfur cluster [ion binding]; other site 694427007000 [2Fe-2S] cluster binding site [ion binding]; other site 694427007001 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 694427007002 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427007003 active site 694427007004 catalytic tetrad [active] 694427007005 LemA family; Region: LemA; cl00742 694427007006 Repair protein; Region: Repair_PSII; cl01535 694427007007 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 694427007008 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 694427007009 Myosin tail; Region: Myosin_tail_1; pfam01576 694427007010 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427007011 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 694427007012 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427007013 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427007014 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007015 YceI-like domain; Region: YceI; cl01001 694427007016 YceI-like domain; Region: YceI; cl01001 694427007017 Predicted transcriptional regulator [Transcription]; Region: COG1959 694427007018 Helix-turn-helix domains; Region: HTH; cl00088 694427007019 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 694427007020 diiron binding motif [ion binding]; other site 694427007021 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 694427007022 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 694427007023 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427007024 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427007025 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427007026 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 694427007027 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694427007028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427007029 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 694427007030 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007031 CsbD-like; Region: CsbD; cl15799 694427007032 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007033 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427007034 ligand binding site [chemical binding]; other site 694427007035 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427007036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007037 active site 694427007038 phosphorylation site [posttranslational modification] 694427007039 intermolecular recognition site; other site 694427007040 PAS fold; Region: PAS; pfam00989 694427007041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007042 putative active site [active] 694427007043 heme pocket [chemical binding]; other site 694427007044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 694427007045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007046 putative active site [active] 694427007047 heme pocket [chemical binding]; other site 694427007048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427007049 dimer interface [polypeptide binding]; other site 694427007050 phosphorylation site [posttranslational modification] 694427007051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007052 ATP binding site [chemical binding]; other site 694427007053 Mg2+ binding site [ion binding]; other site 694427007054 G-X-G motif; other site 694427007055 Response regulator receiver domain; Region: Response_reg; pfam00072 694427007056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007057 active site 694427007058 phosphorylation site [posttranslational modification] 694427007059 intermolecular recognition site; other site 694427007060 dimerization interface [polypeptide binding]; other site 694427007061 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 694427007062 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427007063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427007064 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 694427007065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427007066 Walker A/P-loop; other site 694427007067 ATP binding site [chemical binding]; other site 694427007068 Q-loop/lid; other site 694427007069 ABC transporter signature motif; other site 694427007070 Walker B; other site 694427007071 D-loop; other site 694427007072 H-loop/switch region; other site 694427007073 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 694427007074 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 694427007075 metal binding site [ion binding]; metal-binding site 694427007076 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 694427007077 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 694427007078 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 694427007079 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 694427007080 Ycf48-like protein; Provisional; Region: PRK13684 694427007081 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 694427007082 Surface antigen; Region: Bac_surface_Ag; cl03097 694427007083 TIGR03545 family protein; Region: TIGR03545 694427007084 AsmA family; Region: AsmA; pfam05170 694427007085 Family of unknown function (DUF490); Region: DUF490; pfam04357 694427007086 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 694427007087 FMN binding site [chemical binding]; other site 694427007088 active site 694427007089 substrate binding site [chemical binding]; other site 694427007090 catalytic residue [active] 694427007091 LytTr DNA-binding domain; Region: LytTR; cl04498 694427007092 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 694427007093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427007094 Walker A/P-loop; other site 694427007095 ATP binding site [chemical binding]; other site 694427007096 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 694427007097 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 694427007098 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 694427007099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 694427007100 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 694427007101 K+-transporting ATPase, c chain; Region: KdpC; cl00944 694427007102 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 694427007103 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 694427007104 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 694427007105 Ligand Binding Site [chemical binding]; other site 694427007106 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 694427007107 GAF domain; Region: GAF; cl15785 694427007108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427007109 dimer interface [polypeptide binding]; other site 694427007110 phosphorylation site [posttranslational modification] 694427007111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007112 ATP binding site [chemical binding]; other site 694427007113 Mg2+ binding site [ion binding]; other site 694427007114 G-X-G motif; other site 694427007115 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 694427007116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007117 active site 694427007118 phosphorylation site [posttranslational modification] 694427007119 intermolecular recognition site; other site 694427007120 dimerization interface [polypeptide binding]; other site 694427007121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427007122 DNA binding site [nucleotide binding] 694427007123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427007124 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 694427007125 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 694427007126 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427007127 active site 694427007128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 694427007129 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 694427007130 YtxH-like protein; Region: YtxH; cl02079 694427007131 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007132 Flagellin N-methylase; Region: FliB; cl00497 694427007133 phosphodiesterase; Provisional; Region: PRK12704 694427007134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 694427007135 Cell division protein ZapA; Region: ZapA; cl01146 694427007136 putative transporter; Provisional; Region: PRK11660 694427007137 Sulfate transporter family; Region: Sulfate_transp; cl15842 694427007138 Sulfate transporter family; Region: Sulfate_transp; cl15842 694427007139 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 694427007140 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 694427007141 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 694427007142 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 694427007143 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 694427007144 active site 694427007145 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 694427007146 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 694427007147 motif 1; other site 694427007148 active site 694427007149 motif 2; other site 694427007150 motif 3; other site 694427007151 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 694427007152 DHHA1 domain; Region: DHHA1; pfam02272 694427007153 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427007154 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 694427007155 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 694427007156 putative active site [active] 694427007157 putative metal binding site [ion binding]; other site 694427007158 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 694427007159 Cupin domain; Region: Cupin_2; cl09118 694427007160 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427007161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007162 active site 694427007163 phosphorylation site [posttranslational modification] 694427007164 intermolecular recognition site; other site 694427007165 dimerization interface [polypeptide binding]; other site 694427007166 LytTr DNA-binding domain; Region: LytTR; cl04498 694427007167 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 694427007168 Histidine kinase; Region: His_kinase; pfam06580 694427007169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427007170 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 694427007171 FtsX-like permease family; Region: FtsX; cl15850 694427007172 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427007173 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 694427007174 Walker A/P-loop; other site 694427007175 ATP binding site [chemical binding]; other site 694427007176 Q-loop/lid; other site 694427007177 ABC transporter signature motif; other site 694427007178 Walker B; other site 694427007179 D-loop; other site 694427007180 H-loop/switch region; other site 694427007181 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007182 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007183 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007184 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427007185 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 694427007186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007188 muropeptide transporter; Validated; Region: ampG; PRK11010 694427007189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427007190 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 694427007191 putative active site [active] 694427007192 Stage II sporulation protein; Region: SpoIID; pfam08486 694427007193 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 694427007194 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 694427007195 GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103 694427007196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427007197 active site 694427007198 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427007199 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 694427007200 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 694427007201 putative active site [active] 694427007202 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427007203 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694427007204 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 694427007205 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427007206 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427007207 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427007208 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427007209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427007210 Walker A/P-loop; other site 694427007211 ATP binding site [chemical binding]; other site 694427007212 Q-loop/lid; other site 694427007213 ABC transporter signature motif; other site 694427007214 Walker B; other site 694427007215 D-loop; other site 694427007216 H-loop/switch region; other site 694427007217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 694427007218 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 694427007219 Walker A/P-loop; other site 694427007220 ATP binding site [chemical binding]; other site 694427007221 Q-loop/lid; other site 694427007222 ABC transporter signature motif; other site 694427007223 Walker B; other site 694427007224 D-loop; other site 694427007225 H-loop/switch region; other site 694427007226 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007227 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007228 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007229 Outer membrane efflux protein; Region: OEP; pfam02321 694427007230 Outer membrane efflux protein; Region: OEP; pfam02321 694427007231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427007232 Helix-turn-helix domains; Region: HTH; cl00088 694427007233 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 694427007234 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427007235 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 694427007236 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427007237 putative carbohydrate kinase; Provisional; Region: PRK10565 694427007238 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 694427007239 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 694427007240 putative substrate binding site [chemical binding]; other site 694427007241 putative ATP binding site [chemical binding]; other site 694427007242 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 694427007243 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 694427007244 active site 694427007245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 694427007246 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 694427007247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 694427007248 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 694427007249 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 694427007250 active site 694427007251 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427007252 Protein export membrane protein; Region: SecD_SecF; cl14618 694427007253 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007254 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007255 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007256 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427007257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427007258 Helix-turn-helix domains; Region: HTH; cl00088 694427007259 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007260 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007261 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 694427007262 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 694427007263 gag-polypeptide of LTR copia-type; Region: UBN2; cl15874 694427007264 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 694427007265 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427007266 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427007267 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427007268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007269 active site 694427007270 phosphorylation site [posttranslational modification] 694427007271 intermolecular recognition site; other site 694427007272 dimerization interface [polypeptide binding]; other site 694427007273 LytTr DNA-binding domain; Region: LytTR; cl04498 694427007274 Response regulator receiver domain; Region: Response_reg; pfam00072 694427007275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007276 active site 694427007277 phosphorylation site [posttranslational modification] 694427007278 intermolecular recognition site; other site 694427007279 dimerization interface [polypeptide binding]; other site 694427007280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427007281 PAS domain; Region: PAS_9; pfam13426 694427007282 putative active site [active] 694427007283 heme pocket [chemical binding]; other site 694427007284 PAS domain S-box; Region: sensory_box; TIGR00229 694427007285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007286 putative active site [active] 694427007287 heme pocket [chemical binding]; other site 694427007288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427007289 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427007290 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 694427007291 PAS domain S-box; Region: sensory_box; TIGR00229 694427007292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427007293 PAS domain S-box; Region: sensory_box; TIGR00229 694427007294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427007295 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 694427007296 Histidine kinase; Region: His_kinase; pfam06580 694427007297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007298 PAS domain; Region: PAS_9; pfam13426 694427007299 putative active site [active] 694427007300 heme pocket [chemical binding]; other site 694427007301 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 694427007302 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427007303 substrate binding pocket [chemical binding]; other site 694427007304 catalytic triad [active] 694427007305 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 694427007306 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 694427007307 ATP binding site [chemical binding]; other site 694427007308 profilin binding site; other site 694427007309 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 694427007310 catalytic center binding site [active] 694427007311 ATP binding site [chemical binding]; other site 694427007312 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 694427007313 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 694427007314 catalytic site [active] 694427007315 putative active site [active] 694427007316 putative substrate binding site [chemical binding]; other site 694427007317 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 694427007318 PUA domain; Region: PUA; cl00607 694427007319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427007320 S-adenosylmethionine binding site [chemical binding]; other site 694427007321 RNA polymerase sigma factor; Provisional; Region: PRK12513 694427007322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427007323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427007324 DNA binding residues [nucleotide binding] 694427007325 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 694427007326 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 694427007327 substrate binding site [chemical binding]; other site 694427007328 hexamer interface [polypeptide binding]; other site 694427007329 metal binding site [ion binding]; metal-binding site 694427007330 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 694427007331 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 694427007332 Competence protein; Region: Competence; cl00471 694427007333 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 694427007334 DHH family; Region: DHH; pfam01368 694427007335 DHHA1 domain; Region: DHHA1; pfam02272 694427007336 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 694427007337 Sulfatase; Region: Sulfatase; cl10460 694427007338 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 694427007339 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 694427007340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007341 catalytic residue [active] 694427007342 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 694427007343 amidase catalytic site [active] 694427007344 Zn binding residues [ion binding]; other site 694427007345 substrate binding site [chemical binding]; other site 694427007346 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 694427007347 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 694427007348 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 694427007349 active site 694427007350 Zn binding site [ion binding]; other site 694427007351 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 694427007352 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 694427007353 active site 694427007354 Riboflavin kinase; Region: Flavokinase; cl03312 694427007355 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 694427007356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427007357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007358 active site 694427007359 phosphorylation site [posttranslational modification] 694427007360 intermolecular recognition site; other site 694427007361 dimerization interface [polypeptide binding]; other site 694427007362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427007363 DNA binding site [nucleotide binding] 694427007364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 694427007365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007366 ATP binding site [chemical binding]; other site 694427007367 Mg2+ binding site [ion binding]; other site 694427007368 G-X-G motif; other site 694427007369 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 694427007370 active site 694427007371 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 694427007372 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 694427007373 Bacterial SH3 domain; Region: SH3_3; cl02551 694427007374 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 694427007375 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427007376 PPIC-type PPIASE domain; Region: Rotamase; cl08278 694427007377 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 694427007378 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694427007379 active site 694427007380 catalytic residues [active] 694427007381 Sodium:solute symporter family; Region: SSF; cl00456 694427007382 ribulokinase; Provisional; Region: PRK04123 694427007383 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 694427007384 putative N- and C-terminal domain interface [polypeptide binding]; other site 694427007385 putative active site [active] 694427007386 putative MgATP binding site [chemical binding]; other site 694427007387 catalytic site [active] 694427007388 metal binding site [ion binding]; metal-binding site 694427007389 carbohydrate binding site [chemical binding]; other site 694427007390 homodimer interface [polypeptide binding]; other site 694427007391 L-arabinose isomerase; Provisional; Region: PRK02929 694427007392 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 694427007393 hexamer (dimer of trimers) interface [polypeptide binding]; other site 694427007394 trimer interface [polypeptide binding]; other site 694427007395 substrate binding site [chemical binding]; other site 694427007396 Mn binding site [ion binding]; other site 694427007397 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427007398 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 694427007399 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 694427007400 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 694427007401 intersubunit interface [polypeptide binding]; other site 694427007402 active site 694427007403 Zn2+ binding site [ion binding]; other site 694427007404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 694427007405 nudix motif; other site 694427007406 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427007407 Peptidase S46; Region: Peptidase_S46; pfam10459 694427007408 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 694427007409 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 694427007410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427007411 Walker A/P-loop; other site 694427007412 ATP binding site [chemical binding]; other site 694427007413 Q-loop/lid; other site 694427007414 ABC transporter signature motif; other site 694427007415 Walker B; other site 694427007416 D-loop; other site 694427007417 H-loop/switch region; other site 694427007418 ABC transporter; Region: ABC_tran_2; pfam12848 694427007419 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 694427007420 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 694427007421 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 694427007422 substrate-cofactor binding pocket; other site 694427007423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007424 catalytic residue [active] 694427007425 Flagellin N-methylase; Region: FliB; cl00497 694427007426 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 694427007427 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427007428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427007429 Walker A/P-loop; other site 694427007430 ATP binding site [chemical binding]; other site 694427007431 Q-loop/lid; other site 694427007432 ABC transporter signature motif; other site 694427007433 Walker B; other site 694427007434 D-loop; other site 694427007435 H-loop/switch region; other site 694427007436 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 694427007437 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 694427007438 hinge; other site 694427007439 active site 694427007440 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 694427007441 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 694427007442 dimer interface [polypeptide binding]; other site 694427007443 active site 694427007444 metal binding site [ion binding]; metal-binding site 694427007445 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 694427007446 putative trimer interface [polypeptide binding]; other site 694427007447 putative CoA binding site [chemical binding]; other site 694427007448 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 694427007449 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 694427007450 HflX GTPase family; Region: HflX; cd01878 694427007451 G1 box; other site 694427007452 GTP/Mg2+ binding site [chemical binding]; other site 694427007453 Switch I region; other site 694427007454 G2 box; other site 694427007455 G3 box; other site 694427007456 Switch II region; other site 694427007457 G4 box; other site 694427007458 G5 box; other site 694427007459 cytidylate kinase; Provisional; Region: cmk; PRK00023 694427007460 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 694427007461 CMP-binding site; other site 694427007462 The sites determining sugar specificity; other site 694427007463 LytB protein; Region: LYTB; cl00507 694427007464 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 694427007465 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 694427007466 active site 694427007467 ADP/pyrophosphate binding site [chemical binding]; other site 694427007468 dimerization interface [polypeptide binding]; other site 694427007469 allosteric effector site; other site 694427007470 fructose-1,6-bisphosphate binding site; other site 694427007471 Low molecular weight phosphatase family; Region: LMWPc; cd00115 694427007472 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 694427007473 active site 694427007474 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 694427007475 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 694427007476 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 694427007477 shikimate binding site; other site 694427007478 NAD(P) binding site [chemical binding]; other site 694427007479 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 694427007480 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427007481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427007482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007483 binding surface 694427007484 TPR motif; other site 694427007485 TPR repeat; Region: TPR_11; pfam13414 694427007486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007487 TPR motif; other site 694427007488 binding surface 694427007489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427007490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007491 binding surface 694427007492 TPR motif; other site 694427007493 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681 694427007494 nudix motif; other site 694427007495 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 694427007496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007497 binding surface 694427007498 TPR motif; other site 694427007499 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 694427007500 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 694427007501 Tetratricopeptide repeat; Region: TPR_6; pfam13174 694427007502 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 694427007503 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427007504 Uncharacterized conserved protein [Function unknown]; Region: COG4748 694427007505 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 694427007506 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 694427007507 putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778 694427007508 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427007509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427007511 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 694427007512 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 694427007513 FAD binding pocket [chemical binding]; other site 694427007514 FAD binding motif [chemical binding]; other site 694427007515 phosphate binding motif [ion binding]; other site 694427007516 beta-alpha-beta structure motif; other site 694427007517 NAD binding pocket [chemical binding]; other site 694427007518 Iron coordination center [ion binding]; other site 694427007519 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 694427007520 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427007521 N-terminal plug; other site 694427007522 ligand-binding site [chemical binding]; other site 694427007523 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 694427007524 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 694427007525 Helix-turn-helix domains; Region: HTH; cl00088 694427007526 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 694427007527 N-carbamolyputrescine amidase; Region: PLN02747 694427007528 putative active site; other site 694427007529 catalytic triad [active] 694427007530 putative dimer interface [polypeptide binding]; other site 694427007531 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 694427007532 agmatine deiminase; Region: agmatine_aguA; TIGR03380 694427007533 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 694427007534 Ligand Binding Site [chemical binding]; other site 694427007535 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 694427007536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007537 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 694427007538 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 694427007539 dimer interface [polypeptide binding]; other site 694427007540 active site 694427007541 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427007542 catalytic residues [active] 694427007543 substrate binding site [chemical binding]; other site 694427007544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427007545 ATP binding site [chemical binding]; other site 694427007546 putative Mg++ binding site [ion binding]; other site 694427007547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427007548 nucleotide binding region [chemical binding]; other site 694427007549 ATP-binding site [chemical binding]; other site 694427007550 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 694427007551 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427007552 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427007553 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427007554 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427007555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427007556 binding surface 694427007557 TPR motif; other site 694427007558 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 694427007559 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427007560 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427007561 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 694427007562 transport protein TonB; Provisional; Region: PRK10819 694427007563 Gram-negative bacterial tonB protein; Region: TonB; cl10048 694427007564 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427007565 Helix-turn-helix domains; Region: HTH; cl00088 694427007566 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007567 catalytic residues [active] 694427007568 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 694427007569 active site 694427007570 catalytic triad [active] 694427007571 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 694427007572 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 694427007573 generic binding surface II; other site 694427007574 generic binding surface I; other site 694427007575 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 694427007576 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 694427007577 homooctamer interface [polypeptide binding]; other site 694427007578 active site 694427007579 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 694427007580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427007581 putative substrate translocation pore; other site 694427007582 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 694427007583 active site 694427007584 metal binding site [ion binding]; metal-binding site 694427007585 homotetramer interface [polypeptide binding]; other site 694427007586 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427007587 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 694427007588 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 694427007589 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 694427007590 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 694427007591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007592 RIP metalloprotease RseP; Region: TIGR00054 694427007593 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 694427007594 active site 694427007595 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 694427007596 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 694427007597 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 694427007598 putative substrate binding region [chemical binding]; other site 694427007599 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 694427007600 ArsC family; Region: ArsC; pfam03960 694427007601 putative ArsC-like catalytic residues; other site 694427007602 putative TRX-like catalytic residues [active] 694427007603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427007604 FeS/SAM binding site; other site 694427007605 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 694427007606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007607 binding surface 694427007608 TPR motif; other site 694427007609 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 694427007610 Oligomerisation domain; Region: Oligomerisation; cl00519 694427007611 FtsH Extracellular; Region: FtsH_ext; pfam06480 694427007612 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 694427007613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427007614 Walker A motif; other site 694427007615 ATP binding site [chemical binding]; other site 694427007616 Walker B motif; other site 694427007617 arginine finger; other site 694427007618 Peptidase family M41; Region: Peptidase_M41; pfam01434 694427007619 hypothetical protein; Validated; Region: PRK09039 694427007620 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427007621 ligand binding site [chemical binding]; other site 694427007622 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 694427007623 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 694427007624 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 694427007625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 694427007626 dimer interface [polypeptide binding]; other site 694427007627 active site 694427007628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427007629 catalytic residues [active] 694427007630 substrate binding site [chemical binding]; other site 694427007631 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 694427007632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427007633 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 694427007634 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 694427007635 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427007636 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427007637 AIR carboxylase; Region: AIRC; cl00310 694427007638 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 694427007639 lipoyl attachment site [posttranslational modification]; other site 694427007640 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 694427007641 putative catalytic site [active] 694427007642 putative metal binding site [ion binding]; other site 694427007643 putative phosphate binding site [ion binding]; other site 694427007644 Rhomboid family; Region: Rhomboid; cl11446 694427007645 Rhomboid family; Region: Rhomboid; cl11446 694427007646 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694427007647 IHF - DNA interface [nucleotide binding]; other site 694427007648 IHF dimer interface [polypeptide binding]; other site 694427007649 DJ-1 family protein; Region: not_thiJ; TIGR01383 694427007650 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 694427007651 conserved cys residue [active] 694427007652 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 694427007653 active site 694427007654 hydrophilic channel; other site 694427007655 dimerization interface [polypeptide binding]; other site 694427007656 catalytic residues [active] 694427007657 active site lid [active] 694427007658 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 694427007659 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 694427007660 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 694427007661 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 694427007662 putative active site [active] 694427007663 substrate binding site [chemical binding]; other site 694427007664 putative cosubstrate binding site; other site 694427007665 catalytic site [active] 694427007666 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 694427007667 substrate binding site [chemical binding]; other site 694427007668 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 694427007669 homotrimer interaction site [polypeptide binding]; other site 694427007670 putative active site [active] 694427007671 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 694427007672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427007673 active site 694427007674 HIGH motif; other site 694427007675 nucleotide binding site [chemical binding]; other site 694427007676 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 694427007677 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 694427007678 active site 694427007679 KMSKS motif; other site 694427007680 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 694427007681 tRNA binding surface [nucleotide binding]; other site 694427007682 anticodon binding site; other site 694427007683 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 694427007684 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427007685 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 694427007686 active site 694427007687 dimerization interface [polypeptide binding]; other site 694427007688 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 694427007689 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 694427007690 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 694427007691 phosphate binding site [ion binding]; other site 694427007692 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 694427007693 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 694427007694 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 694427007695 Domain of unknown function DUF21; Region: DUF21; pfam01595 694427007696 gliding motility-associated protein GldE; Region: GldE; TIGR03520 694427007697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694427007698 Transporter associated domain; Region: CorC_HlyC; cl08393 694427007699 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 694427007700 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694427007701 Ligand Binding Site [chemical binding]; other site 694427007702 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694427007703 Ligand Binding Site [chemical binding]; other site 694427007704 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 694427007705 putative catalytic site [active] 694427007706 putative metal binding site [ion binding]; other site 694427007707 putative phosphate binding site [ion binding]; other site 694427007708 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007709 Phosphate transporter family; Region: PHO4; cl00396 694427007710 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 694427007711 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 694427007712 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694427007713 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 694427007714 membrane protein insertase; Provisional; Region: PRK01318 694427007715 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 694427007716 CTP synthetase; Validated; Region: pyrG; PRK05380 694427007717 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 694427007718 Catalytic site [active] 694427007719 active site 694427007720 UTP binding site [chemical binding]; other site 694427007721 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 694427007722 active site 694427007723 putative oxyanion hole; other site 694427007724 catalytic triad [active] 694427007725 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427007726 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 694427007727 active site 694427007728 nucleotide binding site [chemical binding]; other site 694427007729 HIGH motif; other site 694427007730 KMSKS motif; other site 694427007731 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 694427007732 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694427007733 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 694427007734 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 694427007735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007736 catalytic residue [active] 694427007737 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 694427007738 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 694427007739 chorismate binding enzyme; Region: Chorismate_bind; cl10555 694427007740 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 694427007741 Glutamine amidotransferase class-I; Region: GATase; pfam00117 694427007742 glutamine binding [chemical binding]; other site 694427007743 catalytic triad [active] 694427007744 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 694427007745 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 694427007746 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 694427007747 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 694427007748 active site 694427007749 ribulose/triose binding site [chemical binding]; other site 694427007750 phosphate binding site [ion binding]; other site 694427007751 substrate (anthranilate) binding pocket [chemical binding]; other site 694427007752 product (indole) binding pocket [chemical binding]; other site 694427007753 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 694427007754 active site 694427007755 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 694427007756 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 694427007757 substrate binding site [chemical binding]; other site 694427007758 active site 694427007759 catalytic residues [active] 694427007760 heterodimer interface [polypeptide binding]; other site 694427007761 translation initiation factor IF-2; Validated; Region: infB; PRK05306 694427007762 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 694427007763 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 694427007764 G1 box; other site 694427007765 putative GEF interaction site [polypeptide binding]; other site 694427007766 GTP/Mg2+ binding site [chemical binding]; other site 694427007767 Switch I region; other site 694427007768 G2 box; other site 694427007769 G3 box; other site 694427007770 Switch II region; other site 694427007771 G4 box; other site 694427007772 G5 box; other site 694427007773 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 694427007774 Translation-initiation factor 2; Region: IF-2; pfam11987 694427007775 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 694427007776 transcription termination factor NusA; Region: NusA; TIGR01953 694427007777 NusA N-terminal domain; Region: NusA_N; pfam08529 694427007778 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 694427007779 RNA binding site [nucleotide binding]; other site 694427007780 homodimer interface [polypeptide binding]; other site 694427007781 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 694427007782 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 694427007783 G-X-X-G motif; other site 694427007784 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 694427007785 ribosome maturation protein RimP; Reviewed; Region: PRK00092 694427007786 Acetokinase family; Region: Acetate_kinase; cl01029 694427007787 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 694427007788 UGMP family protein; Validated; Region: PRK09604 694427007789 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 694427007790 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 694427007791 Family of unknown function (DUF490); Region: DUF490; pfam04357 694427007792 Protein of unknown function (DUF3256); Region: DUF3256; pfam11644 694427007793 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 694427007794 EamA-like transporter family; Region: EamA; cl01037 694427007795 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 694427007796 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 694427007797 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 694427007798 dimerization interface 3.5A [polypeptide binding]; other site 694427007799 active site 694427007800 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427007801 AMP-binding enzyme; Region: AMP-binding; cl15778 694427007802 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 694427007803 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 694427007804 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 694427007805 putative active site [active] 694427007806 putative substrate binding site [chemical binding]; other site 694427007807 putative cosubstrate binding site; other site 694427007808 catalytic site [active] 694427007809 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007810 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427007811 ligand binding site [chemical binding]; other site 694427007812 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 694427007813 Bacterial Ig-like domain; Region: Big_5; cl01012 694427007814 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427007815 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 694427007816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007818 active site 694427007819 phosphorylation site [posttranslational modification] 694427007820 intermolecular recognition site; other site 694427007821 dimerization interface [polypeptide binding]; other site 694427007822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427007823 DNA binding residues [nucleotide binding] 694427007824 dimerization interface [polypeptide binding]; other site 694427007825 PAS domain S-box; Region: sensory_box; TIGR00229 694427007826 PAS fold; Region: PAS_3; pfam08447 694427007827 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 694427007828 PAS fold; Region: PAS_3; pfam08447 694427007829 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 694427007830 Histidine kinase; Region: HisKA_3; pfam07730 694427007831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007832 ATP binding site [chemical binding]; other site 694427007833 Mg2+ binding site [ion binding]; other site 694427007834 G-X-G motif; other site 694427007835 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427007836 Putative esterase; Region: Esterase; pfam00756 694427007837 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427007838 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 694427007839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 694427007840 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 694427007841 active site 694427007842 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 694427007843 sugar binding site [chemical binding]; other site 694427007844 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 694427007845 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427007846 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427007847 PA14 domain; Region: PA14; cl08459 694427007848 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427007849 Fibronectin type III-like domain; Region: Fn3-like; cl15273 694427007850 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 694427007851 dimer interface [polypeptide binding]; other site 694427007852 ssDNA binding site [nucleotide binding]; other site 694427007853 tetramer (dimer of dimers) interface [polypeptide binding]; other site 694427007854 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 694427007855 L-aspartate oxidase; Provisional; Region: PRK09077 694427007856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007857 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 694427007858 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 694427007859 active site 694427007860 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 694427007861 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 694427007862 NodB motif; other site 694427007863 putative active site [active] 694427007864 putative catalytic site [active] 694427007865 putative Zn binding site [ion binding]; other site 694427007866 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427007867 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 694427007868 DXD motif; other site 694427007869 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 694427007870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427007871 S-adenosylmethionine binding site [chemical binding]; other site 694427007872 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 694427007873 4Fe-4S binding domain; Region: Fer4; cl02805 694427007874 Polysulphide reductase, NrfD; Region: NrfD; cl01295 694427007875 Cytochrome c; Region: Cytochrom_C; cl11414 694427007876 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 694427007877 Cu(I) binding site [ion binding]; other site 694427007878 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 694427007879 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 694427007880 D-pathway; other site 694427007881 Low-spin heme binding site [chemical binding]; other site 694427007882 Putative water exit pathway; other site 694427007883 Binuclear center (active site) [active] 694427007884 K-pathway; other site 694427007885 Putative proton exit pathway; other site 694427007886 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 694427007887 Subunit I/III interface [polypeptide binding]; other site 694427007888 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 694427007889 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 694427007890 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 694427007891 UbiA prenyltransferase family; Region: UbiA; cl00337 694427007892 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427007893 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 694427007894 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427007895 N-terminal plug; other site 694427007896 ligand-binding site [chemical binding]; other site 694427007897 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 694427007898 active site 694427007899 catalytic triad [active] 694427007900 oxyanion hole [active] 694427007901 Isochorismatase family; Region: Isochorismatase; pfam00857 694427007902 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 694427007903 catalytic triad [active] 694427007904 conserved cis-peptide bond; other site 694427007905 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 694427007906 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 694427007907 active site 694427007908 catalytic site [active] 694427007909 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427007910 TIGR03987 family protein; Region: TIGR03987 694427007911 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 694427007912 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 694427007913 active site 694427007914 DNA binding site [nucleotide binding] 694427007915 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 694427007916 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 694427007917 Catalytic site [active] 694427007918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427007919 active site 694427007920 Int/Topo IB signature motif; other site 694427007921 DNA binding site [nucleotide binding] 694427007922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427007923 Walker A motif; other site 694427007924 ATP binding site [chemical binding]; other site 694427007925 Walker B motif; other site 694427007926 arginine finger; other site 694427007927 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 694427007928 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 694427007929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427007930 ATP binding site [chemical binding]; other site 694427007931 putative Mg++ binding site [ion binding]; other site 694427007932 DltD central region; Region: DltD_M; pfam04918 694427007933 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 694427007934 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427007935 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 694427007936 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427007937 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 694427007938 HsdM N-terminal domain; Region: HsdM_N; pfam12161 694427007939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007940 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 694427007941 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427007942 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427007943 ligand binding site [chemical binding]; other site 694427007944 Cadherin repeat-like domain; Region: CA_like; cl15786 694427007945 Cadherin repeat-like domain; Region: CA_like; cl15786 694427007946 Cadherin repeat-like domain; Region: CA_like; cl15786 694427007947 Cadherin repeat-like domain; Region: CA_like; cl15786 694427007948 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 694427007949 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 694427007950 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 694427007951 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427007952 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427007953 Helix-turn-helix domains; Region: HTH; cl00088 694427007954 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 694427007955 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 694427007956 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 694427007957 GDP-binding site [chemical binding]; other site 694427007958 ACT binding site; other site 694427007959 IMP binding site; other site 694427007960 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 694427007961 metal binding site 2 [ion binding]; metal-binding site 694427007962 putative DNA binding helix; other site 694427007963 metal binding site 1 [ion binding]; metal-binding site 694427007964 dimer interface [polypeptide binding]; other site 694427007965 structural Zn2+ binding site [ion binding]; other site 694427007966 A new structural DNA glycosylase; Region: AlkD_like; cd06561 694427007967 active site 694427007968 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427007969 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 694427007970 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 694427007971 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 694427007972 NodB motif; other site 694427007973 active site 694427007974 catalytic site [active] 694427007975 metal binding site [ion binding]; metal-binding site 694427007976 aspartate kinase III; Validated; Region: PRK09084 694427007977 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 694427007978 putative catalytic residues [active] 694427007979 nucleotide binding site [chemical binding]; other site 694427007980 aspartate binding site [chemical binding]; other site 694427007981 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 694427007982 dimer interface [polypeptide binding]; other site 694427007983 allosteric regulatory binding pocket; other site 694427007984 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 694427007985 diaminopimelate decarboxylase; Region: lysA; TIGR01048 694427007986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 694427007987 active site 694427007988 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427007989 substrate binding site [chemical binding]; other site 694427007990 catalytic residues [active] 694427007991 dimer interface [polypeptide binding]; other site 694427007992 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427007993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427007994 active site 694427007995 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427007996 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427007997 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 694427007998 trimer interface [polypeptide binding]; other site 694427007999 active site 694427008000 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 694427008001 catalytic site [active] 694427008002 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 694427008003 nucleotide binding site/active site [active] 694427008004 HIT family signature motif; other site 694427008005 catalytic residue [active] 694427008006 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 694427008007 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 694427008008 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 694427008009 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 694427008010 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694427008011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427008012 FeS/SAM binding site; other site 694427008013 TRAM domain; Region: TRAM; cl01282 694427008014 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 694427008015 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 694427008016 putative Iron-sulfur protein interface [polypeptide binding]; other site 694427008017 proximal heme binding site [chemical binding]; other site 694427008018 distal heme binding site [chemical binding]; other site 694427008019 putative dimer interface [polypeptide binding]; other site 694427008020 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 694427008021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427008022 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 694427008023 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427008024 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 694427008025 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 694427008026 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427008027 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 694427008028 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 694427008029 trimer interface [polypeptide binding]; other site 694427008030 putative metal binding site [ion binding]; other site 694427008031 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 694427008032 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 694427008033 Walker A/P-loop; other site 694427008034 ATP binding site [chemical binding]; other site 694427008035 Q-loop/lid; other site 694427008036 ABC transporter signature motif; other site 694427008037 Walker B; other site 694427008038 D-loop; other site 694427008039 H-loop/switch region; other site 694427008040 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 694427008041 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 694427008042 Walker A/P-loop; other site 694427008043 ATP binding site [chemical binding]; other site 694427008044 Q-loop/lid; other site 694427008045 ABC transporter signature motif; other site 694427008046 Walker B; other site 694427008047 D-loop; other site 694427008048 H-loop/switch region; other site 694427008049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 694427008050 Domain of unknown function (DUF955); Region: DUF955; cl01076 694427008051 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 694427008052 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427008053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427008054 Coenzyme A binding pocket [chemical binding]; other site 694427008055 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 694427008056 LysE type translocator; Region: LysE; cl00565 694427008057 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 694427008058 active site 694427008059 catalytic site [active] 694427008060 substrate binding site [chemical binding]; other site 694427008061 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 694427008062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427008063 non-specific DNA binding site [nucleotide binding]; other site 694427008064 salt bridge; other site 694427008065 sequence-specific DNA binding site [nucleotide binding]; other site 694427008066 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 694427008067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694427008068 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 694427008069 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427008070 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427008071 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427008072 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 694427008073 catalytic motif [active] 694427008074 Zn binding site [ion binding]; other site 694427008075 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427008076 C-terminal peptidase (prc); Region: prc; TIGR00225 694427008077 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694427008078 protein binding site [polypeptide binding]; other site 694427008079 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 694427008080 Catalytic dyad [active] 694427008081 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427008082 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 694427008083 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427008084 active site 694427008085 catalytic site [active] 694427008086 FlgD Ig-like domain; Region: FlgD_ig; cl15790 694427008087 SusE outer membrane protein; Region: SusE; pfam14292 694427008088 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427008089 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427008090 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427008091 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 694427008092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694427008093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427008094 DNA binding site [nucleotide binding] 694427008095 domain linker motif; other site 694427008096 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 694427008097 dimerization interface [polypeptide binding]; other site 694427008098 ligand binding site [chemical binding]; other site 694427008099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427008100 Major Facilitator Superfamily; Region: MFS_1; pfam07690 694427008101 putative substrate translocation pore; other site 694427008102 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 694427008103 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 694427008104 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 694427008105 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 694427008106 Ligand binding site; other site 694427008107 oligomer interface; other site 694427008108 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 694427008109 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427008110 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427008111 ligand binding site [chemical binding]; other site 694427008112 flexible hinge region; other site 694427008113 Helix-turn-helix domains; Region: HTH; cl00088 694427008114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427008115 TPR repeat; Region: TPR_11; pfam13414 694427008116 binding surface 694427008117 TPR motif; other site 694427008118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427008119 binding surface 694427008120 TPR motif; other site 694427008121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427008122 binding surface 694427008123 TPR motif; other site 694427008124 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 694427008125 ABC-2 type transporter; Region: ABC2_membrane; cl11417 694427008126 Survival protein SurE; Region: SurE; cl00448 694427008127 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 694427008128 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 694427008129 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 694427008130 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 694427008131 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 694427008132 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 694427008133 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 694427008134 NodB motif; other site 694427008135 active site 694427008136 catalytic site [active] 694427008137 metal binding site [ion binding]; metal-binding site 694427008138 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 694427008139 Bacterial Ig-like domain; Region: Big_5; cl01012 694427008140 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 694427008141 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 694427008142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427008143 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694427008144 active site 694427008145 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 694427008146 active site 694427008147 DNA polymerase IV; Validated; Region: PRK02406 694427008148 DNA binding site [nucleotide binding] 694427008149 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 694427008150 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 694427008151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427008152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427008153 homodimer interface [polypeptide binding]; other site 694427008154 catalytic residue [active] 694427008155 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 694427008156 histidinol dehydrogenase; Region: hisD; TIGR00069 694427008157 NAD binding site [chemical binding]; other site 694427008158 dimerization interface [polypeptide binding]; other site 694427008159 product binding site; other site 694427008160 substrate binding site [chemical binding]; other site 694427008161 zinc binding site [ion binding]; other site 694427008162 catalytic residues [active] 694427008163 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 694427008164 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 694427008165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427008166 motif II; other site 694427008167 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 694427008168 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 694427008169 active site 694427008170 dimer interface [polypeptide binding]; other site 694427008171 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 694427008172 dimer interface [polypeptide binding]; other site 694427008173 active site 694427008174 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 694427008175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427008176 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 694427008177 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 694427008178 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 694427008179 dimer interface [polypeptide binding]; other site 694427008180 putative anticodon binding site; other site 694427008181 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 694427008182 motif 1; other site 694427008183 active site 694427008184 motif 2; other site 694427008185 motif 3; other site 694427008186 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 694427008187 Phosphotransferase enzyme family; Region: APH; pfam01636 694427008188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 694427008189 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 694427008190 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 694427008191 Substrate binding site; other site 694427008192 metal-binding site 694427008193 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 694427008194 Tetramer interface [polypeptide binding]; other site 694427008195 active site 694427008196 FMN-binding site [chemical binding]; other site 694427008197 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 694427008198 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 694427008199 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 694427008200 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 694427008201 active site 694427008202 metal binding site [ion binding]; metal-binding site 694427008203 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 694427008204 mce related protein; Region: MCE; pfam02470