-- dump date 20120504_154455 -- class Genbank::misc_feature -- table misc_feature_note -- id note 765952000001 multifunctional aminopeptidase A; Provisional; Region: PRK00913 765952000002 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 765952000003 Isochorismatase family; Region: Isochorismatase; pfam00857 765952000004 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 765952000005 catalytic triad [active] 765952000006 dimer interface [polypeptide binding]; other site 765952000007 conserved cis-peptide bond; other site 765952000008 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 765952000009 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765952000010 substrate binding pocket [chemical binding]; other site 765952000011 chain length determination region; other site 765952000012 substrate-Mg2+ binding site; other site 765952000013 catalytic residues [active] 765952000014 aspartate-rich region 1; other site 765952000015 active site lid residues [active] 765952000016 aspartate-rich region 2; other site 765952000017 recombinase A; Provisional; Region: recA; PRK09354 765952000018 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 765952000019 hexamer interface [polypeptide binding]; other site 765952000020 Walker A motif; other site 765952000021 ATP binding site [chemical binding]; other site 765952000022 Walker B motif; other site 765952000023 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 765952000024 active site 765952000025 dimerization interface [polypeptide binding]; other site 765952000026 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 765952000027 ATP cone domain; Region: ATP-cone; pfam03477 765952000028 ATP cone domain; Region: ATP-cone; pfam03477 765952000029 Class I ribonucleotide reductase; Region: RNR_I; cd01679 765952000030 active site 765952000031 dimer interface [polypeptide binding]; other site 765952000032 catalytic residues [active] 765952000033 effector binding site; other site 765952000034 R2 peptide binding site; other site 765952000035 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 765952000036 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 765952000037 dimer interface [polypeptide binding]; other site 765952000038 putative radical transfer pathway; other site 765952000039 diiron center [ion binding]; other site 765952000040 tyrosyl radical; other site 765952000041 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 765952000042 active site 765952000043 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 765952000044 homodimer interface [polypeptide binding]; other site 765952000045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000046 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 765952000047 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 765952000048 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 765952000049 putative trimer interface [polypeptide binding]; other site 765952000050 putative active site [active] 765952000051 putative substrate binding site [chemical binding]; other site 765952000052 putative CoA binding site [chemical binding]; other site 765952000053 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 765952000054 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 765952000055 inhibitor-cofactor binding pocket; inhibition site 765952000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000057 catalytic residue [active] 765952000058 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 765952000059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000060 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 765952000061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000062 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 765952000063 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 765952000064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952000067 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 765952000068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952000070 active site 765952000071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952000072 active site 765952000073 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952000074 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952000075 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 765952000076 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 765952000077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 765952000078 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 765952000079 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 765952000080 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 765952000081 ADP binding site [chemical binding]; other site 765952000082 phosphagen binding site; other site 765952000083 substrate specificity loop; other site 765952000084 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 765952000085 UvrB/uvrC motif; Region: UVR; pfam02151 765952000086 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 765952000087 ribosome recycling factor; Reviewed; Region: frr; PRK00083 765952000088 hinge region; other site 765952000089 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 765952000090 putative nucleotide binding site [chemical binding]; other site 765952000091 uridine monophosphate binding site [chemical binding]; other site 765952000092 homohexameric interface [polypeptide binding]; other site 765952000093 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 765952000094 ligand binding site [chemical binding]; other site 765952000095 active site 765952000096 UGI interface [polypeptide binding]; other site 765952000097 catalytic site [active] 765952000098 TraB family; Region: TraB; cl12050 765952000099 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 765952000100 transmembrane helices; other site 765952000101 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 765952000102 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 765952000103 metal ion-dependent adhesion site (MIDAS); other site 765952000104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000105 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348 765952000106 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 765952000107 putative Iron-sulfur protein interface [polypeptide binding]; other site 765952000108 proximal heme binding site [chemical binding]; other site 765952000109 putative dimer interface [polypeptide binding]; other site 765952000110 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 765952000111 proximal heme binding site [chemical binding]; other site 765952000112 Iron-sulfur protein interface; other site 765952000113 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 765952000114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000115 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 765952000116 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 765952000117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 765952000118 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 765952000119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952000120 Coenzyme A binding pocket [chemical binding]; other site 765952000121 UbiA prenyltransferase family; Region: UbiA; cl00337 765952000122 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 765952000123 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 765952000124 Subunit I/III interface [polypeptide binding]; other site 765952000125 Subunit III/IV interface [polypeptide binding]; other site 765952000126 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 765952000127 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 765952000128 D-pathway; other site 765952000129 Putative ubiquinol binding site [chemical binding]; other site 765952000130 Low-spin heme (heme b) binding site [chemical binding]; other site 765952000131 Putative water exit pathway; other site 765952000132 Binuclear center (heme o3/CuB) [ion binding]; other site 765952000133 K-pathway; other site 765952000134 Putative proton exit pathway; other site 765952000135 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 765952000136 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 765952000137 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 765952000138 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 765952000139 Transposase domain (DUF772); Region: DUF772; cl15789 765952000140 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 765952000141 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 765952000142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952000143 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952000144 excinuclease ABC subunit B; Provisional; Region: PRK05298 765952000145 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 765952000146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000147 ATP-binding site [chemical binding]; other site 765952000148 ATP binding site [chemical binding]; other site 765952000149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000150 nucleotide binding region [chemical binding]; other site 765952000151 ATP-binding site [chemical binding]; other site 765952000152 Ultra-violet resistance protein B; Region: UvrB; pfam12344 765952000153 UvrB/uvrC motif; Region: UVR; pfam02151 765952000154 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 765952000155 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 765952000156 active site 765952000157 HIGH motif; other site 765952000158 dimer interface [polypeptide binding]; other site 765952000159 KMSKS motif; other site 765952000160 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 765952000161 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952000162 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 765952000163 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952000164 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952000165 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000166 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000167 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000168 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000169 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000170 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952000171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952000172 dimer interface [polypeptide binding]; other site 765952000173 putative CheW interface [polypeptide binding]; other site 765952000174 TspO/MBR family; Region: TspO_MBR; cl01379 765952000175 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 765952000176 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952000177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765952000178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952000179 active site 765952000180 phosphorylation site [posttranslational modification] 765952000181 intermolecular recognition site; other site 765952000182 dimerization interface [polypeptide binding]; other site 765952000183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765952000184 DNA binding site [nucleotide binding] 765952000185 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 765952000186 MatE; Region: MatE; cl10513 765952000187 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 765952000188 Integral membrane protein TerC family; Region: TerC; cl10468 765952000189 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 765952000190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000191 putative substrate translocation pore; other site 765952000192 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952000193 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 765952000194 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952000195 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952000196 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952000197 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348 765952000198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952000199 Family description; Region: UvrD_C_2; cl15862 765952000200 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 765952000201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952000202 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 765952000203 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 765952000204 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 765952000205 BON domain; Region: BON; cl02771 765952000206 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 765952000207 dimerization interface [polypeptide binding]; other site 765952000208 metal binding site [ion binding]; metal-binding site 765952000209 CsbD-like; Region: CsbD; cl15799 765952000210 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 765952000211 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 765952000212 YtxH-like protein; Region: YtxH; cl02079 765952000213 YtxH-like protein; Region: YtxH; cl02079 765952000214 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 765952000215 Uncharacterized conserved protein [Function unknown]; Region: COG3287 765952000216 FIST N domain; Region: FIST; cl10701 765952000217 FIST C domain; Region: FIST_C; pfam10442 765952000218 Uncharacterized conserved protein [Function unknown]; Region: COG3287 765952000219 FIST N domain; Region: FIST; cl10701 765952000220 FIST C domain; Region: FIST_C; pfam10442 765952000221 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 765952000222 competence damage-inducible protein A; Provisional; Region: PRK00549 765952000223 putative MPT binding site; other site 765952000224 Competence-damaged protein; Region: CinA; cl00666 765952000225 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 765952000226 ligand binding site [chemical binding]; other site 765952000227 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 765952000228 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 765952000229 putative peptidoglycan binding site; other site 765952000230 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 765952000231 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 765952000232 catalytic residue [active] 765952000233 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 765952000234 isocitrate dehydrogenase; Validated; Region: PRK09222 765952000235 KpsF/GutQ family protein; Region: kpsF; TIGR00393 765952000236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 765952000237 putative active site [active] 765952000238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 765952000239 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 765952000240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952000241 ATP binding site [chemical binding]; other site 765952000242 putative Mg++ binding site [ion binding]; other site 765952000243 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 765952000244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000245 nucleotide binding region [chemical binding]; other site 765952000246 ATP-binding site [chemical binding]; other site 765952000247 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 765952000248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765952000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000250 homodimer interface [polypeptide binding]; other site 765952000251 catalytic residue [active] 765952000252 rod shape-determining protein MreC; Region: MreC; pfam04085 765952000253 rod shape-determining protein MreC; Region: MreC; pfam04085 765952000254 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 765952000255 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 765952000256 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 765952000257 16S rRNA methyltransferase B; Provisional; Region: PRK14902 765952000258 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 765952000259 putative RNA binding site [nucleotide binding]; other site 765952000260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 765952000261 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 765952000262 Protein of unknown function (DUF692); Region: DUF692; cl01263 765952000263 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 765952000264 peptide chain release factor 2; Validated; Region: prfB; PRK00578 765952000265 RF-1 domain; Region: RF-1; cl02875 765952000266 RF-1 domain; Region: RF-1; cl02875 765952000267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952000268 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952000269 SprT-like family; Region: SprT-like; pfam10263 765952000270 Transcriptional regulator; Region: Transcrip_reg; cl00361 765952000271 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 765952000272 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 765952000273 chorismate binding enzyme; Region: Chorismate_bind; cl10555 765952000274 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952000275 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 765952000276 putative NAD(P) binding site [chemical binding]; other site 765952000277 active site 765952000278 putative substrate binding site [chemical binding]; other site 765952000279 YGGT family; Region: YGGT; cl00508 765952000280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 765952000281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 765952000282 FMN binding site [chemical binding]; other site 765952000283 active site 765952000284 catalytic residues [active] 765952000285 substrate binding site [chemical binding]; other site 765952000286 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 765952000287 type III secretion system protein; Validated; Region: PRK06328 765952000288 Flagellar assembly protein FliH; Region: FliH; pfam02108 765952000289 FliP family; Region: FliP; cl00593 765952000290 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 765952000291 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 765952000292 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 765952000293 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 765952000294 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 765952000295 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 765952000296 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 765952000297 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 765952000298 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 765952000299 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 765952000300 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765952000301 Clp protease; Region: CLP_protease; pfam00574 765952000302 oligomer interface [polypeptide binding]; other site 765952000303 active site residues [active] 765952000304 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 765952000305 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 765952000306 hinge; other site 765952000307 active site 765952000308 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 765952000309 homotrimer interaction site [polypeptide binding]; other site 765952000310 zinc binding site [ion binding]; other site 765952000311 CDP-binding sites; other site 765952000312 FAD binding domain; Region: FAD_binding_1; pfam00667 765952000313 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 765952000314 FAD binding pocket [chemical binding]; other site 765952000315 FAD binding motif [chemical binding]; other site 765952000316 catalytic residues [active] 765952000317 NAD binding pocket [chemical binding]; other site 765952000318 phosphate binding motif [ion binding]; other site 765952000319 beta-alpha-beta structure motif; other site 765952000320 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 765952000321 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952000322 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952000323 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765952000324 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 765952000325 Walker A/P-loop; other site 765952000326 ATP binding site [chemical binding]; other site 765952000327 Q-loop/lid; other site 765952000328 ABC transporter signature motif; other site 765952000329 Walker B; other site 765952000330 D-loop; other site 765952000331 H-loop/switch region; other site 765952000332 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 765952000333 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 765952000334 Walker A/P-loop; other site 765952000335 ATP binding site [chemical binding]; other site 765952000336 Q-loop/lid; other site 765952000337 ABC transporter signature motif; other site 765952000338 Walker B; other site 765952000339 D-loop; other site 765952000340 H-loop/switch region; other site 765952000341 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 765952000342 ABC-2 type transporter; Region: ABC2_membrane; cl11417 765952000343 ABC-2 type transporter; Region: ABC2_membrane; cl11417 765952000344 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952000345 aconitate hydratase; Validated; Region: PRK09277 765952000346 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 765952000347 substrate binding site [chemical binding]; other site 765952000348 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 765952000349 ligand binding site [chemical binding]; other site 765952000350 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 765952000351 substrate binding site [chemical binding]; other site 765952000352 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 765952000353 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 765952000354 active site 765952000355 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952000356 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952000357 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 765952000358 GIY-YIG motif/motif A; other site 765952000359 active site 765952000360 catalytic site [active] 765952000361 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952000362 RHS Repeat; Region: RHS_repeat; cl11982 765952000363 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952000364 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 765952000365 active site 765952000366 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 765952000367 RNAase interaction site [polypeptide binding]; other site 765952000368 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 765952000369 Transposase domain (DUF772); Region: DUF772; cl15789 765952000370 Integrase core domain; Region: rve; cl01316 765952000371 Winged helix-turn helix; Region: HTH_33; pfam13592 765952000372 Helix-turn-helix domains; Region: HTH; cl00088 765952000373 Winged helix-turn helix; Region: HTH_29; pfam13551 765952000374 Winged helix-turn helix; Region: HTH_33; pfam13592 765952000375 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952000376 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 765952000377 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 765952000378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952000379 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952000380 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952000381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952000382 active site 765952000383 SWIB/MDM2 domain; Region: SWIB; cl02489 765952000384 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 765952000385 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952000386 putative active site [active] 765952000387 putative metal binding site [ion binding]; other site 765952000388 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 765952000389 substrate binding site; other site 765952000390 dimer interface; other site 765952000391 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 765952000392 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 765952000393 dimerization interface 3.5A [polypeptide binding]; other site 765952000394 active site 765952000395 Thymidylate synthase complementing protein; Region: Thy1; cl03630 765952000396 Thymidylate synthase complementing protein; Region: Thy1; cl03630 765952000397 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 765952000398 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765952000399 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765952000400 ring oligomerisation interface [polypeptide binding]; other site 765952000401 ATP/Mg binding site [chemical binding]; other site 765952000402 stacking interactions; other site 765952000403 hinge regions; other site 765952000404 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 765952000405 oligomerisation interface [polypeptide binding]; other site 765952000406 mobile loop; other site 765952000407 roof hairpin; other site 765952000408 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 765952000409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952000410 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952000411 ABC-ATPase subunit interface; other site 765952000412 dimer interface [polypeptide binding]; other site 765952000413 putative PBP binding regions; other site 765952000414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952000415 ABC-ATPase subunit interface; other site 765952000416 dimer interface [polypeptide binding]; other site 765952000417 putative PBP binding regions; other site 765952000418 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 765952000419 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 765952000420 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 765952000421 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765952000422 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765952000423 intersubunit interface [polypeptide binding]; other site 765952000424 Protein of unknown function (DUF971); Region: DUF971; cl01414 765952000425 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 765952000426 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 765952000427 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952000428 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 765952000429 S-adenosylmethionine synthetase; Validated; Region: PRK05250 765952000430 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 765952000431 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 765952000432 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 765952000433 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 765952000434 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 765952000435 Domain of unknown function (DUF814); Region: DUF814; pfam05670 765952000436 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 765952000437 polysaccharide export protein Wza; Provisional; Region: PRK15078 765952000438 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 765952000439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000440 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 765952000441 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 765952000442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000443 S-adenosylmethionine binding site [chemical binding]; other site 765952000444 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 765952000445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765952000446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000447 homodimer interface [polypeptide binding]; other site 765952000448 catalytic residue [active] 765952000449 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 765952000450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000451 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 765952000452 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 765952000453 dihydrodipicolinate synthase; Region: dapA; TIGR00674 765952000454 dimer interface [polypeptide binding]; other site 765952000455 active site 765952000456 catalytic residue [active] 765952000457 dihydrodipicolinate reductase; Provisional; Region: PRK00048 765952000458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000459 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 765952000460 polysaccharide export protein Wza; Provisional; Region: PRK15078 765952000461 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 765952000462 RasGAP: Ras-GTPase Activating Domain. RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras...; Region: RasGAP; cl02569 765952000463 GAP/RAS interaction site [polypeptide binding]; other site 765952000464 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 765952000465 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 765952000466 putative ligand binding site [chemical binding]; other site 765952000467 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 765952000468 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 765952000469 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 765952000470 lipoyl attachment site [posttranslational modification]; other site 765952000471 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 765952000472 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 765952000473 tetramer interface [polypeptide binding]; other site 765952000474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000475 catalytic residue [active] 765952000476 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 765952000477 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765952000478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952000479 catalytic residue [active] 765952000480 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 765952000481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000482 ATP binding site [chemical binding]; other site 765952000483 putative Mg++ binding site [ion binding]; other site 765952000484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000485 nucleotide binding region [chemical binding]; other site 765952000486 ATP-binding site [chemical binding]; other site 765952000487 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952000488 GTP cyclohydrolase I; Provisional; Region: PLN03044 765952000489 active site 765952000490 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952000491 active site 765952000492 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 765952000493 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 765952000494 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952000495 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952000496 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 765952000497 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 765952000498 active site 765952000499 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000500 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000501 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000502 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000503 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000504 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 765952000505 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765952000506 E3 interaction surface; other site 765952000507 lipoyl attachment site [posttranslational modification]; other site 765952000508 e3 binding domain; Region: E3_binding; pfam02817 765952000509 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 765952000510 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 765952000511 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 765952000512 alpha subunit interface [polypeptide binding]; other site 765952000513 TPP binding site [chemical binding]; other site 765952000514 heterodimer interface [polypeptide binding]; other site 765952000515 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952000516 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 765952000517 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 765952000518 tetramer interface [polypeptide binding]; other site 765952000519 TPP-binding site [chemical binding]; other site 765952000520 heterodimer interface [polypeptide binding]; other site 765952000521 phosphorylation loop region [posttranslational modification] 765952000522 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 765952000523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000524 putative substrate translocation pore; other site 765952000525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000526 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 765952000527 active site 765952000528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952000529 enoyl-CoA hydratase; Provisional; Region: PRK05995 765952000530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952000531 substrate binding site [chemical binding]; other site 765952000532 oxyanion hole (OAH) forming residues; other site 765952000533 trimer interface [polypeptide binding]; other site 765952000534 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 765952000535 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952000536 putative catalytic site [active] 765952000537 putative metal binding site [ion binding]; other site 765952000538 putative phosphate binding site [ion binding]; other site 765952000539 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952000540 putative catalytic site [active] 765952000541 putative metal binding site [ion binding]; other site 765952000542 putative phosphate binding site [ion binding]; other site 765952000543 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 765952000544 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 765952000545 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 765952000546 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 765952000547 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 765952000548 active site 765952000549 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 765952000550 Phosphate transporter family; Region: PHO4; cl00396 765952000551 aminopeptidase N; Provisional; Region: pepN; PRK14015 765952000552 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 765952000553 active site 765952000554 Zn binding site [ion binding]; other site 765952000555 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 765952000556 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 765952000557 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 765952000558 hypothetical protein; Reviewed; Region: PRK09588 765952000559 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952000560 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 765952000561 putative NAD(P) binding site [chemical binding]; other site 765952000562 putative substrate binding site [chemical binding]; other site 765952000563 catalytic Zn binding site [ion binding]; other site 765952000564 structural Zn binding site [ion binding]; other site 765952000565 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000566 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000567 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000568 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000569 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952000571 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 765952000572 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765952000573 active site residue [active] 765952000574 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765952000575 active site residue [active] 765952000576 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 765952000577 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 765952000578 active site 765952000579 DNA binding site [nucleotide binding] 765952000580 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 765952000581 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 765952000582 Catalytic site [active] 765952000583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 765952000584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000585 hypothetical protein; Reviewed; Region: PRK09588 765952000586 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 765952000587 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 765952000588 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 765952000589 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 765952000590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000591 ATP binding site [chemical binding]; other site 765952000592 putative Mg++ binding site [ion binding]; other site 765952000593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000594 nucleotide binding region [chemical binding]; other site 765952000595 ATP-binding site [chemical binding]; other site 765952000596 TRCF domain; Region: TRCF; cl04088 765952000597 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 765952000598 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 765952000599 motif 1; other site 765952000600 active site 765952000601 motif 2; other site 765952000602 motif 3; other site 765952000603 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 765952000604 DHHA1 domain; Region: DHHA1; pfam02272 765952000605 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 765952000606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000607 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952000608 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952000609 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 765952000610 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 765952000611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 765952000612 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 765952000613 ATP-dependent protease La; Region: lon; TIGR00763 765952000614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952000615 Walker A motif; other site 765952000616 ATP binding site [chemical binding]; other site 765952000617 Walker B motif; other site 765952000618 arginine finger; other site 765952000619 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 765952000620 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952000621 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 765952000622 active site 765952000623 nucleotide binding site [chemical binding]; other site 765952000624 HIGH motif; other site 765952000625 KMSKS motif; other site 765952000626 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 765952000627 Rhomboid family; Region: Rhomboid; cl11446 765952000628 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952000629 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 765952000630 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952000631 active site 765952000632 DNA binding site [nucleotide binding] 765952000633 Int/Topo IB signature motif; other site 765952000634 F-box domain; Region: F-box; cl02535 765952000635 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000636 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000637 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 765952000638 active site 765952000639 nucleophile elbow; other site 765952000640 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 765952000641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952000642 Walker A/P-loop; other site 765952000643 ATP binding site [chemical binding]; other site 765952000644 Q-loop/lid; other site 765952000645 ABC transporter signature motif; other site 765952000646 Walker B; other site 765952000647 D-loop; other site 765952000648 H-loop/switch region; other site 765952000649 ABC transporter; Region: ABC_tran_2; pfam12848 765952000650 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 765952000651 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 765952000652 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952000653 GTP cyclohydrolase I; Provisional; Region: PLN03044 765952000654 active site 765952000655 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 765952000656 Predicted membrane protein [Function unknown]; Region: COG4129 765952000657 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 765952000658 flavoprotein, HI0933 family; Region: TIGR00275 765952000659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000661 S-adenosylmethionine binding site [chemical binding]; other site 765952000662 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 765952000663 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 765952000664 Protein export membrane protein; Region: SecD_SecF; cl14618 765952000665 Protein export membrane protein; Region: SecD_SecF; cl14618 765952000666 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000667 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 765952000668 BTB/POZ domain; Region: BTB; cl02518 765952000669 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000670 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952000671 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 765952000672 DHH family; Region: DHH; pfam01368 765952000673 DHHA1 domain; Region: DHHA1; pfam02272 765952000674 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 765952000675 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 765952000676 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 765952000677 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 765952000678 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 765952000679 Sulfate transporter family; Region: Sulfate_transp; cl15842 765952000680 putative transporter; Provisional; Region: PRK11660 765952000681 Sulfate transporter family; Region: Sulfate_transp; cl15842 765952000682 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 765952000683 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952000684 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 765952000685 Walker A/P-loop; other site 765952000686 ATP binding site [chemical binding]; other site 765952000687 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 765952000688 Q-loop/lid; other site 765952000689 ABC transporter signature motif; other site 765952000690 Walker B; other site 765952000691 D-loop; other site 765952000692 H-loop/switch region; other site 765952000693 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952000694 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952000695 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952000696 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 765952000697 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 765952000698 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 765952000699 active site 765952000700 zinc binding site [ion binding]; other site 765952000701 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 765952000702 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 765952000703 SpaB C-terminal domain; Region: SpaB_C; cl14828 765952000704 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 765952000705 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 765952000706 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 765952000707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000708 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 765952000709 DNA-K related protein; Region: DUF3731; pfam12531 765952000710 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 765952000711 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 765952000712 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952000713 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952000714 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 765952000715 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 765952000716 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765952000717 HIGH motif; other site 765952000718 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765952000719 active site 765952000720 KMSKS motif; other site 765952000721 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 765952000722 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 765952000723 protein binding site [polypeptide binding]; other site 765952000724 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 765952000725 Catalytic dyad [active] 765952000726 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 765952000727 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 765952000728 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 765952000729 Competence protein; Region: Competence; cl00471 765952000730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 765952000731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 765952000732 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 765952000733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765952000734 dimer interface [polypeptide binding]; other site 765952000735 phosphorylation site [posttranslational modification] 765952000736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952000737 ATP binding site [chemical binding]; other site 765952000738 Mg2+ binding site [ion binding]; other site 765952000739 G-X-G motif; other site 765952000740 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 765952000741 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 765952000742 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 765952000743 active site 765952000744 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 765952000745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952000746 ATP binding site [chemical binding]; other site 765952000747 Mg2+ binding site [ion binding]; other site 765952000748 G-X-G motif; other site 765952000749 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 765952000750 ATP binding site [chemical binding]; other site 765952000751 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 765952000752 lysophospholipid transporter LplT; Provisional; Region: PRK11195 765952000753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000754 putative substrate translocation pore; other site 765952000755 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765952000756 putative acyl-acceptor binding pocket; other site 765952000757 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 765952000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000759 S-adenosylmethionine binding site [chemical binding]; other site 765952000760 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952000761 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952000762 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 765952000763 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 765952000764 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 765952000765 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 765952000766 active site 765952000767 dimerization interface [polypeptide binding]; other site 765952000768 YacP-like NYN domain; Region: NYN_YacP; cl01491 765952000769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000770 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 765952000771 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 765952000772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000773 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952000774 putative acyl-acceptor binding pocket; other site 765952000775 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 765952000776 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 765952000777 homodimer interface [polypeptide binding]; other site 765952000778 oligonucleotide binding site [chemical binding]; other site 765952000779 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 765952000780 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 765952000781 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 765952000782 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 765952000783 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 765952000784 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 765952000785 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 765952000786 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 765952000787 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 765952000788 active site 765952000789 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952000790 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 765952000791 putative acyl-acceptor binding pocket; other site 765952000792 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 765952000793 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 765952000794 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 765952000795 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 765952000796 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 765952000797 Ligand binding site; other site 765952000798 Putative Catalytic site; other site 765952000799 DXD motif; other site 765952000800 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 765952000801 poly(A) polymerase; Region: pcnB; TIGR01942 765952000802 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 765952000803 active site 765952000804 NTP binding site [chemical binding]; other site 765952000805 metal binding triad [ion binding]; metal-binding site 765952000806 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 765952000807 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 765952000808 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952000809 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 765952000810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000811 ATP binding site [chemical binding]; other site 765952000812 putative Mg++ binding site [ion binding]; other site 765952000813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000814 nucleotide binding region [chemical binding]; other site 765952000815 ATP-binding site [chemical binding]; other site 765952000816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000818 active site 765952000819 GTP-binding protein Der; Reviewed; Region: PRK00093 765952000820 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 765952000821 G1 box; other site 765952000822 GTP/Mg2+ binding site [chemical binding]; other site 765952000823 Switch I region; other site 765952000824 G2 box; other site 765952000825 Switch II region; other site 765952000826 G3 box; other site 765952000827 G4 box; other site 765952000828 G5 box; other site 765952000829 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 765952000830 G1 box; other site 765952000831 GTP/Mg2+ binding site [chemical binding]; other site 765952000832 Switch I region; other site 765952000833 G2 box; other site 765952000834 G3 box; other site 765952000835 Switch II region; other site 765952000836 G4 box; other site 765952000837 G5 box; other site 765952000838 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952000839 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 765952000840 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 765952000841 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952000842 structural tetrad; other site 765952000843 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 765952000844 Sulfate transporter family; Region: Sulfate_transp; cl15842 765952000845 Sulfate transporter family; Region: Sulfate_transp; cl15842 765952000846 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 765952000847 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 765952000848 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 765952000849 anti sigma factor interaction site; other site 765952000850 regulatory phosphorylation site [posttranslational modification]; other site 765952000851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952000852 TPR motif; other site 765952000853 binding surface 765952000854 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765952000855 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 765952000856 rRNA interaction site [nucleotide binding]; other site 765952000857 S8 interaction site; other site 765952000858 putative laminin-1 binding site; other site 765952000859 elongation factor Ts; Provisional; Region: tsf; PRK09377 765952000860 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 765952000861 Elongation factor TS; Region: EF_TS; pfam00889 765952000862 Elongation factor TS; Region: EF_TS; pfam00889 765952000863 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 765952000864 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952000865 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 765952000866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952000867 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 765952000868 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 765952000869 Deoxyhypusine synthase; Region: DS; cl00826 765952000870 Arginase family; Region: Arginase; cl00306 765952000871 arginine decarboxylase; Provisional; Region: PRK05354 765952000872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 765952000873 dimer interface [polypeptide binding]; other site 765952000874 active site 765952000875 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765952000876 catalytic residues [active] 765952000877 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 765952000878 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765952000879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952000880 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952000881 NAD synthetase; Provisional; Region: PRK13981 765952000882 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 765952000883 multimer interface [polypeptide binding]; other site 765952000884 active site 765952000885 catalytic triad [active] 765952000886 protein interface 1 [polypeptide binding]; other site 765952000887 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 765952000888 homodimer interface [polypeptide binding]; other site 765952000889 NAD binding pocket [chemical binding]; other site 765952000890 ATP binding pocket [chemical binding]; other site 765952000891 Mg binding site [ion binding]; other site 765952000892 active-site loop [active] 765952000893 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 765952000894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765952000895 catalytic loop [active] 765952000896 iron binding site [ion binding]; other site 765952000897 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 765952000898 FAD binding pocket [chemical binding]; other site 765952000899 FAD binding motif [chemical binding]; other site 765952000900 phosphate binding motif [ion binding]; other site 765952000901 beta-alpha-beta structure motif; other site 765952000902 NAD binding pocket [chemical binding]; other site 765952000903 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 765952000904 FMN binding site [chemical binding]; other site 765952000905 active site 765952000906 catalytic residues [active] 765952000907 substrate binding site [chemical binding]; other site 765952000908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000909 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 765952000910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000911 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 765952000912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000913 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 765952000914 Cation transport protein; Region: TrkH; cl10514 765952000915 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 765952000916 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 765952000917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000918 S-adenosylmethionine binding site [chemical binding]; other site 765952000919 Cadherin repeat-like domain; Region: CA_like; cl15786 765952000920 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 765952000921 Phosphotransferase enzyme family; Region: APH; pfam01636 765952000922 active site 765952000923 ATP binding site [chemical binding]; other site 765952000924 substrate binding site [chemical binding]; other site 765952000925 dimer interface [polypeptide binding]; other site 765952000926 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 765952000927 Predicted RNA interaction site [nucleotide binding]; other site 765952000928 putative binding site; other site 765952000929 Mutations affecting start-site selection; other site 765952000930 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952000931 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 765952000932 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 765952000933 NAD binding site [chemical binding]; other site 765952000934 substrate binding site [chemical binding]; other site 765952000935 homodimer interface [polypeptide binding]; other site 765952000936 active site 765952000937 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 765952000938 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 765952000939 substrate binding site; other site 765952000940 tetramer interface; other site 765952000941 Cupin domain; Region: Cupin_2; cl09118 765952000942 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 765952000943 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 765952000944 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 765952000945 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 765952000946 dimerization interface [polypeptide binding]; other site 765952000947 active site 765952000948 metal binding site [ion binding]; metal-binding site 765952000949 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 765952000950 DNA repair protein RadA; Provisional; Region: PRK11823 765952000951 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 765952000952 Walker A motif/ATP binding site; other site 765952000953 ATP binding site [chemical binding]; other site 765952000954 Walker B motif; other site 765952000955 porphobilinogen deaminase; Provisional; Region: PRK01066 765952000956 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 765952000957 domain interfaces; other site 765952000958 active site 765952000959 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 765952000960 active site 765952000961 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 765952000962 Protein phosphatase 2C; Region: PP2C; pfam00481 765952000963 active site 765952000964 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 765952000965 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 765952000966 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 765952000967 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 765952000968 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 765952000969 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765952000970 trimer interface [polypeptide binding]; other site 765952000971 active site 765952000972 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765952000973 active site 765952000974 phosphorylation site [posttranslational modification] 765952000975 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 765952000976 DNA binding residues [nucleotide binding] 765952000977 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765952000978 active site 765952000979 phosphorylation site [posttranslational modification] 765952000980 F-box domain; Region: F-box; cl02535 765952000981 Clp protease ATP binding subunit; Region: clpC; CHL00095 765952000982 Clp amino terminal domain; Region: Clp_N; pfam02861 765952000983 Clp amino terminal domain; Region: Clp_N; pfam02861 765952000984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952000985 Walker A motif; other site 765952000986 ATP binding site [chemical binding]; other site 765952000987 Walker B motif; other site 765952000988 arginine finger; other site 765952000989 UvrB/uvrC motif; Region: UVR; pfam02151 765952000990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952000991 Walker A motif; other site 765952000992 ATP binding site [chemical binding]; other site 765952000993 Walker B motif; other site 765952000994 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 765952000995 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 765952000996 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 765952000997 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 765952000998 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 765952000999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952001000 catalytic residue [active] 765952001001 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 765952001002 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 765952001003 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 765952001004 FeS assembly ATPase SufC; Region: sufC; TIGR01978 765952001005 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 765952001006 Walker A/P-loop; other site 765952001007 ATP binding site [chemical binding]; other site 765952001008 Q-loop/lid; other site 765952001009 ABC transporter signature motif; other site 765952001010 Walker B; other site 765952001011 D-loop; other site 765952001012 H-loop/switch region; other site 765952001013 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 765952001014 putative ABC transporter; Region: ycf24; CHL00085 765952001015 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765952001016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952001017 RNA binding surface [nucleotide binding]; other site 765952001018 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 765952001019 active site 765952001020 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 765952001021 active site 765952001022 catalytic residues [active] 765952001023 F-box domain; Region: F-box; cl02535 765952001024 Helix-turn-helix domains; Region: HTH; cl00088 765952001025 Winged helix-turn helix; Region: HTH_33; pfam13592 765952001026 Integrase core domain; Region: rve; cl01316 765952001027 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001028 PemK-like protein; Region: PemK; cl00995 765952001029 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001030 MULE transposase domain; Region: MULE; pfam10551 765952001031 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001032 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 765952001033 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952001034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001035 binding surface 765952001036 TPR motif; other site 765952001037 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952001038 Tetratricopeptide repeat; Region: TPR_3; pfam07720 765952001039 Tir chaperone protein (CesT) family; Region: CesT; cl08444 765952001040 Transposase domain (DUF772); Region: DUF772; cl15789 765952001041 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 765952001042 Transposase domain (DUF772); Region: DUF772; cl15789 765952001043 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952001044 Transposase domain (DUF772); Region: DUF772; cl15789 765952001045 Tir chaperone protein (CesT) family; Region: CesT; cl08444 765952001046 Tir chaperone protein (CesT) family; Region: CesT; cl08444 765952001047 Transposase domain (DUF772); Region: DUF772; cl15789 765952001048 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952001049 Transposase domain (DUF772); Region: DUF772; cl15789 765952001050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001051 G1 box; other site 765952001052 GTP/Mg2+ binding site [chemical binding]; other site 765952001053 G2 box; other site 765952001054 Switch I region; other site 765952001055 hypothetical protein; Provisional; Region: PRK11281 765952001056 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 765952001057 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001058 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001059 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001060 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001061 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001062 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001063 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001064 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001065 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 765952001066 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 765952001067 catalytic triad [active] 765952001068 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952001069 active site 765952001070 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 765952001071 aromatic arch; other site 765952001072 DCoH dimer interaction site [polypeptide binding]; other site 765952001073 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 765952001074 DCoH tetramer interaction site [polypeptide binding]; other site 765952001075 substrate binding site [chemical binding]; other site 765952001076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001077 Q-loop/lid; other site 765952001078 ABC transporter signature motif; other site 765952001079 Walker B; other site 765952001080 D-loop; other site 765952001081 H-loop/switch region; other site 765952001082 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 765952001083 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 765952001084 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 765952001085 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 765952001086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765952001088 phosphopeptide binding site; other site 765952001089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765952001090 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 765952001091 phosphopeptide binding site; other site 765952001092 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765952001093 type III secretion system ATPase; Provisional; Region: PRK06315 765952001094 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 765952001095 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 765952001096 Walker A motif/ATP binding site; other site 765952001097 Walker B motif; other site 765952001098 type III secretion system protein; Validated; Region: PRK05933 765952001099 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 765952001100 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 765952001101 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952001102 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952001103 active site 765952001104 ATP binding site [chemical binding]; other site 765952001105 substrate binding site [chemical binding]; other site 765952001106 activation loop (A-loop); other site 765952001107 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 765952001108 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952001109 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 765952001110 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001111 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001112 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 765952001113 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 765952001114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952001115 binding surface 765952001116 TPR motif; other site 765952001117 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 765952001118 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001119 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001120 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 765952001121 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 765952001122 Haemolytic domain; Region: Haemolytic; cl00506 765952001123 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 765952001124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001125 putative carbohydrate kinase; Provisional; Region: PRK10565 765952001126 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 765952001127 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 765952001128 putative substrate binding site [chemical binding]; other site 765952001129 putative ATP binding site [chemical binding]; other site 765952001130 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 765952001131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001132 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 765952001133 serine hydroxymethyltransferase; Provisional; Region: PRK13580 765952001134 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 765952001135 dimer interface [polypeptide binding]; other site 765952001136 active site 765952001137 glycine-pyridoxal phosphate binding site [chemical binding]; other site 765952001138 folate binding site [chemical binding]; other site 765952001139 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 765952001140 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 765952001141 Putative zinc ribbon domain; Region: DUF164; pfam02591 765952001142 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 765952001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001144 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 765952001145 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 765952001146 putative catalytic cysteine [active] 765952001147 gamma-glutamyl kinase; Provisional; Region: PRK05429 765952001148 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 765952001149 nucleotide binding site [chemical binding]; other site 765952001150 homotetrameric interface [polypeptide binding]; other site 765952001151 putative phosphate binding site [ion binding]; other site 765952001152 putative allosteric binding site; other site 765952001153 PUA domain; Region: PUA; cl00607 765952001154 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 765952001155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001156 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 765952001157 substrate binding site [chemical binding]; other site 765952001158 active site 765952001159 transketolase; Reviewed; Region: PRK05899 765952001160 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 765952001161 TPP-binding site [chemical binding]; other site 765952001162 dimer interface [polypeptide binding]; other site 765952001163 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765952001164 PYR/PP interface [polypeptide binding]; other site 765952001165 dimer interface [polypeptide binding]; other site 765952001166 TPP binding site [chemical binding]; other site 765952001167 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952001168 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 765952001169 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952001170 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 765952001171 NodB motif; other site 765952001172 putative active site [active] 765952001173 putative catalytic site [active] 765952001174 putative Zn binding site [ion binding]; other site 765952001175 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 765952001176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952001177 CCC1-related family of proteins; Region: CCC1_like; cl00278 765952001178 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 765952001179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952001180 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001181 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 765952001182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001183 NAD(P) binding pocket [chemical binding]; other site 765952001184 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 765952001185 HrcA protein C terminal domain; Region: HrcA; pfam01628 765952001186 heat shock protein GrpE; Provisional; Region: PRK14154 765952001187 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 765952001188 dimer interface [polypeptide binding]; other site 765952001189 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 765952001190 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 765952001191 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 765952001192 active site clefts [active] 765952001193 zinc binding site [ion binding]; other site 765952001194 dimer interface [polypeptide binding]; other site 765952001195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001196 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 765952001197 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 765952001198 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 765952001199 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 765952001200 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952001201 Peptidase M16C associated; Region: M16C_assoc; pfam08367 765952001202 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952001203 integrase; Provisional; Region: int; PHA02601 765952001204 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952001205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952001206 Coenzyme A binding pocket [chemical binding]; other site 765952001207 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952001208 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952001209 nudix motif; other site 765952001210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765952001211 Helix-turn-helix domains; Region: HTH; cl00088 765952001212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 765952001213 dimerization interface [polypeptide binding]; other site 765952001214 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001215 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001216 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001217 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765952001218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001219 Walker A/P-loop; other site 765952001220 ATP binding site [chemical binding]; other site 765952001221 Q-loop/lid; other site 765952001222 ABC transporter signature motif; other site 765952001223 Walker B; other site 765952001224 D-loop; other site 765952001225 H-loop/switch region; other site 765952001226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952001227 dimer interface [polypeptide binding]; other site 765952001228 conserved gate region; other site 765952001229 putative PBP binding loops; other site 765952001230 ABC-ATPase subunit interface; other site 765952001231 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952001232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952001233 substrate binding pocket [chemical binding]; other site 765952001234 membrane-bound complex binding site; other site 765952001235 hinge residues; other site 765952001236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765952001237 Helix-turn-helix domains; Region: HTH; cl00088 765952001238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 765952001239 dimerization interface [polypeptide binding]; other site 765952001240 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 765952001241 putative homodimer interface [polypeptide binding]; other site 765952001242 putative homotetramer interface [polypeptide binding]; other site 765952001243 putative allosteric switch controlling residues; other site 765952001244 putative metal binding site [ion binding]; other site 765952001245 putative homodimer-homodimer interface [polypeptide binding]; other site 765952001246 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765952001247 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765952001248 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952001249 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952001250 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 765952001251 active site 765952001252 dimerization interface [polypeptide binding]; other site 765952001253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 765952001254 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 765952001255 active site 765952001256 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 765952001257 glycyl-tRNA synthetase; Provisional; Region: PRK04173 765952001258 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 765952001259 motif 1; other site 765952001260 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 765952001261 active site 765952001262 motif 2; other site 765952001263 motif 3; other site 765952001264 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 765952001265 anticodon binding site; other site 765952001266 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765952001267 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 765952001268 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 765952001269 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 765952001270 Phosphate transporter family; Region: PHO4; cl00396 765952001271 Phosphate transporter family; Region: PHO4; cl00396 765952001272 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 765952001273 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 765952001274 S17 interaction site [polypeptide binding]; other site 765952001275 S8 interaction site; other site 765952001276 16S rRNA interaction site [nucleotide binding]; other site 765952001277 streptomycin interaction site [chemical binding]; other site 765952001278 23S rRNA interaction site [nucleotide binding]; other site 765952001279 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 765952001280 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 765952001281 elongation factor G; Reviewed; Region: PRK12739 765952001282 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 765952001283 G1 box; other site 765952001284 putative GEF interaction site [polypeptide binding]; other site 765952001285 GTP/Mg2+ binding site [chemical binding]; other site 765952001286 Switch I region; other site 765952001287 G2 box; other site 765952001288 G3 box; other site 765952001289 Switch II region; other site 765952001290 G4 box; other site 765952001291 G5 box; other site 765952001292 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 765952001293 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 765952001294 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 765952001295 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 765952001296 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 765952001297 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 765952001298 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 765952001299 pyruvate phosphate dikinase; Provisional; Region: PRK09279 765952001300 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765952001301 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 765952001302 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 765952001303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001304 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 765952001305 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 765952001306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952001307 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 765952001308 active site 765952001309 metal binding site [ion binding]; metal-binding site 765952001310 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 765952001311 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 765952001312 tandem repeat interface [polypeptide binding]; other site 765952001313 oligomer interface [polypeptide binding]; other site 765952001314 active site residues [active] 765952001315 DNA polymerase I; Provisional; Region: PRK05755 765952001316 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 765952001317 active site 765952001318 metal binding site 1 [ion binding]; metal-binding site 765952001319 putative 5' ssDNA interaction site; other site 765952001320 metal binding site 3; metal-binding site 765952001321 metal binding site 2 [ion binding]; metal-binding site 765952001322 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 765952001323 putative DNA binding site [nucleotide binding]; other site 765952001324 putative metal binding site [ion binding]; other site 765952001325 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 765952001326 active site 765952001327 catalytic site [active] 765952001328 substrate binding site [chemical binding]; other site 765952001329 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 765952001330 active site 765952001331 DNA binding site [nucleotide binding] 765952001332 catalytic site [active] 765952001333 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 765952001334 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 765952001335 CoA-binding site [chemical binding]; other site 765952001336 ATP-binding [chemical binding]; other site 765952001337 transcription termination factor Rho; Provisional; Region: rho; PRK09376 765952001338 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 765952001339 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 765952001340 RNA binding site [nucleotide binding]; other site 765952001341 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 765952001342 multimer interface [polypeptide binding]; other site 765952001343 Walker A motif; other site 765952001344 ATP binding site [chemical binding]; other site 765952001345 Walker B motif; other site 765952001346 DNA polymerase III PolC; Validated; Region: polC; PRK00448 765952001347 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 765952001348 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 765952001349 active site 765952001350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765952001351 catalytic residues [active] 765952001352 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 765952001353 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 765952001354 active site 765952001355 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765952001356 catalytic residues [active] 765952001357 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 765952001358 GTP1/OBG; Region: GTP1_OBG; pfam01018 765952001359 Obg GTPase; Region: Obg; cd01898 765952001360 G1 box; other site 765952001361 GTP/Mg2+ binding site [chemical binding]; other site 765952001362 Switch I region; other site 765952001363 G2 box; other site 765952001364 G3 box; other site 765952001365 Switch II region; other site 765952001366 G4 box; other site 765952001367 G5 box; other site 765952001368 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 765952001369 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 765952001370 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 765952001371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001372 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952001373 C-terminal peptidase (prc); Region: prc; TIGR00225 765952001374 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 765952001375 protein binding site [polypeptide binding]; other site 765952001376 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 765952001377 Catalytic dyad [active] 765952001378 ScpA/B protein; Region: ScpA_ScpB; cl00598 765952001379 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 765952001380 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 765952001381 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 765952001382 Walker A/P-loop; other site 765952001383 ATP binding site [chemical binding]; other site 765952001384 Q-loop/lid; other site 765952001385 ABC transporter signature motif; other site 765952001386 Walker B; other site 765952001387 D-loop; other site 765952001388 H-loop/switch region; other site 765952001389 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765952001390 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 765952001391 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 765952001392 Walker A/P-loop; other site 765952001393 ATP binding site [chemical binding]; other site 765952001394 Q-loop/lid; other site 765952001395 ABC transporter signature motif; other site 765952001396 Walker B; other site 765952001397 D-loop; other site 765952001398 H-loop/switch region; other site 765952001399 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765952001400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952001401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952001402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952001403 S-adenosylmethionine binding site [chemical binding]; other site 765952001404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001405 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 765952001406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952001407 RNA binding surface [nucleotide binding]; other site 765952001408 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 765952001409 active site 765952001410 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 765952001411 putative tRNA-binding site [nucleotide binding]; other site 765952001412 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765952001413 catalytic core [active] 765952001414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765952001415 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 765952001416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952001417 catalytic residue [active] 765952001418 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 765952001419 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 765952001420 NifU-like domain; Region: NifU; cl00484 765952001421 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 765952001422 ADP-ribose binding site [chemical binding]; other site 765952001423 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 765952001424 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 765952001425 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 765952001426 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 765952001427 Walker A/P-loop; other site 765952001428 ATP binding site [chemical binding]; other site 765952001429 Q-loop/lid; other site 765952001430 ABC transporter signature motif; other site 765952001431 Walker B; other site 765952001432 D-loop; other site 765952001433 H-loop/switch region; other site 765952001434 ABC transporter; Region: ABC_tran_2; pfam12848 765952001435 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 765952001436 F-box domain; Region: F-box; cl02535 765952001437 F-box domain; Region: F-box; cl02535 765952001438 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952001439 ABC-2 type transporter; Region: ABC2_membrane; cl11417 765952001440 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 765952001441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001442 Walker A/P-loop; other site 765952001443 ATP binding site [chemical binding]; other site 765952001444 Q-loop/lid; other site 765952001445 ABC transporter signature motif; other site 765952001446 Walker B; other site 765952001447 D-loop; other site 765952001448 H-loop/switch region; other site 765952001449 oxidoreductase; Region: PLN02485 765952001450 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 765952001451 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 765952001452 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 765952001453 Recombination protein O N terminal; Region: RecO_N; cl15812 765952001454 Recombination protein O C terminal; Region: RecO_C; pfam02565 765952001455 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952001456 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952001457 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765952001458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952001459 RNA binding surface [nucleotide binding]; other site 765952001460 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 765952001461 active site 765952001462 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 765952001463 dimerization interface [polypeptide binding]; other site 765952001464 putative tRNAtyr binding site [nucleotide binding]; other site 765952001465 putative active site [active] 765952001466 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 765952001467 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 765952001468 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952001469 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 765952001470 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 765952001471 dimer interface [polypeptide binding]; other site 765952001472 PYR/PP interface [polypeptide binding]; other site 765952001473 TPP binding site [chemical binding]; other site 765952001474 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 765952001475 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 765952001476 TPP-binding site [chemical binding]; other site 765952001477 dimer interface [polypeptide binding]; other site 765952001478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952001479 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 765952001480 active site 765952001481 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765952001482 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 765952001483 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 765952001484 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 765952001485 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 765952001486 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 765952001487 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 765952001488 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 765952001489 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 765952001490 active site 765952001491 substrate binding site [chemical binding]; other site 765952001492 Mg2+ binding site [ion binding]; other site 765952001493 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 765952001494 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 765952001495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952001496 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765952001497 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 765952001498 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 765952001499 Active site serine [active] 765952001500 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 765952001501 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 765952001502 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 765952001503 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 765952001504 active site 765952001505 Zn binding site [ion binding]; other site 765952001506 Protein of unknown function (DUF541); Region: SIMPL; cl01077 765952001507 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 765952001508 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 765952001509 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 765952001510 ATP-binding site [chemical binding]; other site 765952001511 Sugar specificity; other site 765952001512 Pyrimidine base specificity; other site 765952001513 primosome assembly protein PriA; Validated; Region: PRK05580 765952001514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952001515 ATP binding site [chemical binding]; other site 765952001516 putative Mg++ binding site [ion binding]; other site 765952001517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001518 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001519 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001520 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001521 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765952001523 HSP70 interaction site [polypeptide binding]; other site 765952001524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952001525 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765952001526 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 765952001527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952001528 Walker A/P-loop; other site 765952001529 ATP binding site [chemical binding]; other site 765952001530 Q-loop/lid; other site 765952001531 ABC transporter signature motif; other site 765952001532 Walker B; other site 765952001533 D-loop; other site 765952001534 H-loop/switch region; other site 765952001535 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 765952001536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 765952001537 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 765952001538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952001539 dimer interface [polypeptide binding]; other site 765952001540 conserved gate region; other site 765952001541 putative PBP binding loops; other site 765952001542 ABC-ATPase subunit interface; other site 765952001543 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 765952001544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952001545 dimer interface [polypeptide binding]; other site 765952001546 conserved gate region; other site 765952001547 putative PBP binding loops; other site 765952001548 ABC-ATPase subunit interface; other site 765952001549 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 765952001550 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 765952001551 Walker A/P-loop; other site 765952001552 ATP binding site [chemical binding]; other site 765952001553 Q-loop/lid; other site 765952001554 ABC transporter signature motif; other site 765952001555 Walker B; other site 765952001556 D-loop; other site 765952001557 H-loop/switch region; other site 765952001558 TOBE domain; Region: TOBE_2; cl01440 765952001559 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 765952001560 AMP-binding enzyme; Region: AMP-binding; cl15778 765952001561 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 765952001562 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 765952001563 dimer interface [polypeptide binding]; other site 765952001564 active site 765952001565 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 765952001566 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952001567 substrate binding site [chemical binding]; other site 765952001568 oxyanion hole (OAH) forming residues; other site 765952001569 trimer interface [polypeptide binding]; other site 765952001570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001571 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 765952001572 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 765952001573 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 765952001574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952001575 Walker A motif; other site 765952001576 ATP binding site [chemical binding]; other site 765952001577 Walker B motif; other site 765952001578 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 765952001579 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 765952001580 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 765952001581 metal binding site [ion binding]; metal-binding site 765952001582 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 765952001583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001584 NAD(P) binding site [chemical binding]; other site 765952001585 active site 765952001586 AMP-binding enzyme; Region: AMP-binding; cl15778 765952001587 acyl-CoA synthetase; Validated; Region: PRK07798 765952001588 Tir chaperone protein (CesT) family; Region: CesT; cl08444 765952001589 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 765952001590 HrpJ-like domain; Region: HrpJ; cl15454 765952001591 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 765952001592 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 765952001593 type III secretion system protein; Validated; Region: PRK06298 765952001594 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 765952001595 GTP-binding protein YchF; Reviewed; Region: PRK09601 765952001596 YchF GTPase; Region: YchF; cd01900 765952001597 G1 box; other site 765952001598 GTP/Mg2+ binding site [chemical binding]; other site 765952001599 Switch I region; other site 765952001600 G2 box; other site 765952001601 Switch II region; other site 765952001602 G3 box; other site 765952001603 G4 box; other site 765952001604 G5 box; other site 765952001605 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 765952001606 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 765952001607 THUMP domain; Region: THUMP; cl12076 765952001608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001609 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 765952001610 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 765952001611 ParB-like partition proteins; Region: parB_part; TIGR00180 765952001612 ParB-like nuclease domain; Region: ParBc; cl02129 765952001613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 765952001614 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952001615 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952001616 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952001617 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 765952001618 metal ion-dependent adhesion site (MIDAS); other site 765952001619 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 765952001620 metal ion-dependent adhesion site (MIDAS); other site 765952001621 Oxygen tolerance; Region: BatD; pfam13584 765952001622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952001623 Bacterial SH3 domain; Region: SH3_3; cl02551 765952001624 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 765952001625 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 765952001626 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 765952001627 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765952001628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952001629 FeS/SAM binding site; other site 765952001630 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 765952001631 23S rRNA interface [nucleotide binding]; other site 765952001632 L3 interface [polypeptide binding]; other site 765952001633 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 765952001634 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952001635 putative catalytic site [active] 765952001636 putative metal binding site [ion binding]; other site 765952001637 putative phosphate binding site [ion binding]; other site 765952001638 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 765952001639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001640 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 765952001641 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765952001642 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 765952001643 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 765952001644 mce related protein; Region: MCE; pfam02470 765952001645 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 765952001646 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 765952001647 Walker A/P-loop; other site 765952001648 ATP binding site [chemical binding]; other site 765952001649 Q-loop/lid; other site 765952001650 ABC transporter signature motif; other site 765952001651 Walker B; other site 765952001652 D-loop; other site 765952001653 H-loop/switch region; other site 765952001654 Permease; Region: Permease; cl00510 765952001655 Family of unknown function (DUF490); Region: DUF490; pfam04357 765952001656 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 765952001657 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765952001658 Surface antigen; Region: Bac_surface_Ag; cl03097 765952001659 Acylphosphatase; Region: Acylphosphatase; cl00551 765952001660 putative cation:proton antiport protein; Provisional; Region: PRK10669 765952001661 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765952001662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001663 LytB protein; Region: LYTB; cl00507 765952001664 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 765952001665 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 765952001666 DEAD-like helicases superfamily; Region: DEXDc; smart00487 765952001667 ATP binding site [chemical binding]; other site 765952001668 Mg++ binding site [ion binding]; other site 765952001669 motif III; other site 765952001670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952001671 nucleotide binding region [chemical binding]; other site 765952001672 ATP-binding site [chemical binding]; other site 765952001673 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765952001674 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952001675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952001676 Transporter associated domain; Region: CorC_HlyC; cl08393 765952001677 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765952001678 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952001679 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952001680 Transporter associated domain; Region: CorC_HlyC; cl08393 765952001681 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765952001682 trimer interface [polypeptide binding]; other site 765952001683 active site 765952001684 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 765952001685 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952001686 nudix motif; other site 765952001687 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 765952001688 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 765952001689 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765952001690 HSP70 interaction site [polypeptide binding]; other site 765952001691 Membrane protein of unknown function; Region: DUF360; cl00850 765952001692 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952001693 Sel1 repeat; Region: Sel1; cl02723 765952001694 Sel1 repeat; Region: Sel1; cl02723 765952001695 Sel1 repeat; Region: Sel1; cl02723 765952001696 Sel1 repeat; Region: Sel1; cl02723 765952001697 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952001698 Sel1 repeat; Region: Sel1; cl02723 765952001699 Sel1 repeat; Region: Sel1; cl02723 765952001700 Sel1 repeat; Region: Sel1; cl02723 765952001701 Sel1 repeat; Region: Sel1; cl02723 765952001702 Sel1 repeat; Region: Sel1; cl02723 765952001703 Sel1 repeat; Region: Sel1; cl02723 765952001704 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 765952001705 Tetratricopeptide repeat; Region: TPR_3; pfam07720 765952001706 Tetratricopeptide repeat; Region: TPR_3; pfam07720 765952001707 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 765952001708 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 765952001709 ATP-grasp domain; Region: ATP-grasp_4; cl03087 765952001710 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 765952001711 N-formylglutamate amidohydrolase; Region: FGase; cl01522 765952001712 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 765952001713 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 765952001714 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 765952001715 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 765952001716 active site 765952001717 substrate binding site [chemical binding]; other site 765952001718 metal binding site [ion binding]; metal-binding site 765952001719 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 765952001720 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 765952001721 Flagellin N-methylase; Region: FliB; cl00497 765952001722 F-box domain; Region: F-box; cl02535 765952001723 F-box domain; Region: F-box; cl02535 765952001724 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765952001725 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 765952001726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952001727 ABC-ATPase subunit interface; other site 765952001728 dimer interface [polypeptide binding]; other site 765952001729 putative PBP binding regions; other site 765952001730 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765952001731 intersubunit interface [polypeptide binding]; other site 765952001732 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765952001733 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765952001734 ring oligomerisation interface [polypeptide binding]; other site 765952001735 ATP/Mg binding site [chemical binding]; other site 765952001736 stacking interactions; other site 765952001737 hinge regions; other site 765952001738 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 765952001739 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 765952001740 dimerization interface [polypeptide binding]; other site 765952001741 active site 765952001742 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 765952001743 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 765952001744 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 765952001745 ligand binding site; other site 765952001746 oligomer interface; other site 765952001747 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 765952001748 N-terminal domain interface [polypeptide binding]; other site 765952001749 sulfate 1 binding site; other site 765952001750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952001751 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 765952001752 putative active site [active] 765952001753 putative metal binding site [ion binding]; other site 765952001754 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 765952001755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001756 NAD(P) binding site [chemical binding]; other site 765952001757 active site 765952001758 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 765952001759 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 765952001760 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 765952001761 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 765952001762 active site 765952001763 interdomain interaction site; other site 765952001764 putative metal-binding site [ion binding]; other site 765952001765 nucleotide binding site [chemical binding]; other site 765952001766 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 765952001767 domain I; other site 765952001768 DNA binding groove [nucleotide binding] 765952001769 phosphate binding site [ion binding]; other site 765952001770 domain II; other site 765952001771 domain III; other site 765952001772 nucleotide binding site [chemical binding]; other site 765952001773 catalytic site [active] 765952001774 domain IV; other site 765952001775 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 765952001776 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 765952001777 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 765952001778 SWIB/MDM2 domain; Region: SWIB; cl02489 765952001779 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 765952001780 TIGR02452 family protein; Region: TIGR02452 765952001781 cytidine deaminase, homodimeric; Region: cyt_deam_dimer; TIGR01355 765952001782 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 765952001783 active site 765952001784 catalytic motif [active] 765952001785 Zn binding site [ion binding]; other site 765952001786 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 765952001787 active site 765952001788 catalytic motif [active] 765952001789 Zn binding site [ion binding]; other site 765952001790 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952001791 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 765952001792 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 765952001793 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 765952001794 putative peptidoglycan binding site; other site 765952001795 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 765952001796 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 765952001797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952001798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765952001799 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 765952001800 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 765952001801 Mg++ binding site [ion binding]; other site 765952001802 putative catalytic motif [active] 765952001803 putative substrate binding site [chemical binding]; other site 765952001804 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952001805 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 765952001806 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952001807 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 765952001808 Fatty acid desaturase; Region: FA_desaturase; pfam00487 765952001809 Di-iron ligands [ion binding]; other site 765952001810 Predicted methyltransferases [General function prediction only]; Region: COG0313 765952001811 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 765952001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 765952001813 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 765952001814 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 765952001815 active site 765952001816 dimer interface [polypeptide binding]; other site 765952001817 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 765952001818 dimer interface [polypeptide binding]; other site 765952001819 active site 765952001820 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 765952001821 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 765952001822 active site 765952001823 Int/Topo IB signature motif; other site 765952001824 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952001825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952001826 binding surface 765952001827 TPR motif; other site 765952001828 ApbE family; Region: ApbE; cl00643 765952001829 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 765952001830 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 765952001831 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 765952001832 homodimer interface [polypeptide binding]; other site 765952001833 NADP binding site [chemical binding]; other site 765952001834 substrate binding site [chemical binding]; other site 765952001835 K+ potassium transporter; Region: K_trans; cl15781 765952001836 Amino acid permease; Region: AA_permease_2; pfam13520 765952001837 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 765952001838 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 765952001839 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 765952001840 RNase E interface [polypeptide binding]; other site 765952001841 trimer interface [polypeptide binding]; other site 765952001842 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 765952001843 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 765952001844 RNase E interface [polypeptide binding]; other site 765952001845 trimer interface [polypeptide binding]; other site 765952001846 active site 765952001847 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 765952001848 putative nucleic acid binding region [nucleotide binding]; other site 765952001849 G-X-X-G motif; other site 765952001850 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 765952001851 RNA binding site [nucleotide binding]; other site 765952001852 domain interface; other site 765952001853 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 765952001854 16S/18S rRNA binding site [nucleotide binding]; other site 765952001855 S13e-L30e interaction site [polypeptide binding]; other site 765952001856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952001857 S-adenosylmethionine binding site [chemical binding]; other site 765952001858 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 765952001859 active sites [active] 765952001860 tetramer interface [polypeptide binding]; other site 765952001861 urocanate hydratase; Provisional; Region: PRK05414 765952001862 imidazolonepropionase; Validated; Region: PRK09356 765952001863 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 765952001864 active site 765952001865 Arginase family; Region: Arginase; cl00306 765952001866 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 765952001867 Protein of unknown function (DUF502); Region: DUF502; cl01107 765952001868 Protein of unknown function (DUF502); Region: DUF502; cl01107 765952001869 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 765952001870 active site 765952001871 DNA binding site [nucleotide binding] 765952001872 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 765952001873 substrate binding site [chemical binding]; other site 765952001874 dimer interface [polypeptide binding]; other site 765952001875 catalytic triad [active] 765952001876 Preprotein translocase SecG subunit; Region: SecG; cl09123 765952001877 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 765952001878 active site 765952001879 catalytic residues [active] 765952001880 metal binding site [ion binding]; metal-binding site 765952001881 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 765952001882 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952001883 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 765952001884 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952001885 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001886 F-box domain; Region: F-box; cl02535 765952001887 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001888 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001889 Domain of unknown function (DUF386); Region: DUF386; cl01047 765952001890 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001891 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001892 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 765952001893 DNA binding residues [nucleotide binding] 765952001894 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 765952001895 catalytic nucleophile [active] 765952001896 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 765952001897 catalytic residues [active] 765952001898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001899 short chain dehydrogenase; Validated; Region: PRK07069 765952001900 NAD(P) binding site [chemical binding]; other site 765952001901 active site 765952001902 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952001903 nudix motif; other site 765952001904 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765952001905 nucleotide binding site/active site [active] 765952001906 HIT family signature motif; other site 765952001907 catalytic residue [active] 765952001908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 765952001909 SEC-C motif; Region: SEC-C; pfam02810 765952001910 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952001911 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 765952001912 Recombinase; Region: Recombinase; pfam07508 765952001913 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 765952001914 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001915 MULE transposase domain; Region: MULE; pfam10551 765952001916 Transposase domain (DUF772); Region: DUF772; cl15789 765952001917 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 765952001918 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 765952001919 Integrase core domain; Region: rve; cl01316 765952001920 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 765952001921 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952001922 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 765952001923 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 765952001924 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 765952001925 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001926 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001927 MULE transposase domain; Region: MULE; pfam10551 765952001928 Zeta toxin; Region: Zeta_toxin; pfam06414 765952001929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952001930 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765952001931 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952001932 active site 765952001933 catalytic tetrad [active] 765952001934 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 765952001935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001936 NAD(P) binding site [chemical binding]; other site 765952001937 active site 765952001938 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952001939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001940 NmrA-like family; Region: NmrA; pfam05368 765952001941 NAD(P) binding site [chemical binding]; other site 765952001942 active site 765952001943 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 765952001944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952001945 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 765952001946 putative substrate translocation pore; other site 765952001947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952001948 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 765952001949 putative active site [active] 765952001950 putative metal binding site [ion binding]; other site 765952001951 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952001952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952001953 F-box domain; Region: F-box; cl02535 765952001954 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 765952001955 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 765952001956 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 765952001957 putative NAD(P) binding site [chemical binding]; other site 765952001958 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 765952001959 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 765952001960 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765952001961 active site 765952001962 catalytic site [active] 765952001963 substrate binding site [chemical binding]; other site 765952001964 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 765952001965 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 765952001966 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765952001967 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 765952001968 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 765952001969 NAD(P) binding site [chemical binding]; other site 765952001970 homotetramer interface [polypeptide binding]; other site 765952001971 homodimer interface [polypeptide binding]; other site 765952001972 active site 765952001973 Acyl transferase domain; Region: Acyl_transf_1; cl08282 765952001974 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 765952001975 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 765952001976 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 765952001977 dimer interface [polypeptide binding]; other site 765952001978 active site 765952001979 CoA binding pocket [chemical binding]; other site 765952001980 recombination protein RecR; Reviewed; Region: recR; PRK00076 765952001981 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 765952001982 putative active site [active] 765952001983 putative metal-binding site [ion binding]; other site 765952001984 tetramer interface [polypeptide binding]; other site 765952001985 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 765952001986 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765952001987 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765952001988 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765952001989 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765952001990 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 765952001991 Surface antigen; Region: Bac_surface_Ag; cl03097 765952001992 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 765952001993 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 765952001994 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 765952001995 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 765952001996 trimer interface [polypeptide binding]; other site 765952001997 active site 765952001998 UDP-GlcNAc binding site [chemical binding]; other site 765952001999 lipid binding site [chemical binding]; lipid-binding site 765952002000 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 765952002001 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 765952002002 active site 765952002003 homotetramer interface [polypeptide binding]; other site 765952002004 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 765952002005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952002006 active site 765952002007 motif I; other site 765952002008 motif II; other site 765952002009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952002010 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 765952002011 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 765952002012 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 765952002013 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 765952002014 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002015 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 765952002016 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 765952002017 DNA binding site [nucleotide binding] 765952002018 catalytic residue [active] 765952002019 H2TH interface [polypeptide binding]; other site 765952002020 putative catalytic residues [active] 765952002021 turnover-facilitating residue; other site 765952002022 intercalation triad [nucleotide binding]; other site 765952002023 8OG recognition residue [nucleotide binding]; other site 765952002024 putative reading head residues; other site 765952002025 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 765952002026 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 765952002027 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 765952002028 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 765952002029 HIGH motif; other site 765952002030 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 765952002031 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952002032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952002033 active site 765952002034 KMSKS motif; other site 765952002035 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 765952002036 tRNA binding surface [nucleotide binding]; other site 765952002037 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765952002038 Ligand Binding Site [chemical binding]; other site 765952002039 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765952002040 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765952002041 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952002042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002043 S-adenosylmethionine binding site [chemical binding]; other site 765952002044 ribonuclease R; Region: RNase_R; TIGR02063 765952002045 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952002046 RNB domain; Region: RNB; pfam00773 765952002047 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 765952002048 RNA binding site [nucleotide binding]; other site 765952002049 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 765952002050 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 765952002051 generic binding surface II; other site 765952002052 generic binding surface I; other site 765952002053 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 765952002054 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 765952002055 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 765952002056 TPP-binding site; other site 765952002057 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765952002058 PYR/PP interface [polypeptide binding]; other site 765952002059 dimer interface [polypeptide binding]; other site 765952002060 TPP binding site [chemical binding]; other site 765952002061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952002062 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 765952002063 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 765952002064 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 765952002065 Fibronectin type III-like domain; Region: Fn3-like; cl15273 765952002066 Fibronectin type III-like domain; Region: Fn3-like; cl15273 765952002067 Fibronectin type III-like domain; Region: Fn3-like; cl15273 765952002068 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 765952002069 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 765952002070 catalytic Zn binding site [ion binding]; other site 765952002071 structural Zn binding site [ion binding]; other site 765952002072 NAD(P) binding site [chemical binding]; other site 765952002073 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 765952002074 putative RNA binding site [nucleotide binding]; other site 765952002075 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 765952002076 FAD binding domain; Region: FAD_binding_4; pfam01565 765952002077 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 765952002078 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 765952002079 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 765952002080 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952002081 Fatty acid desaturase; Region: FA_desaturase; pfam00487 765952002082 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 765952002083 putative di-iron ligands [ion binding]; other site 765952002084 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 765952002085 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 765952002086 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 765952002087 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 765952002088 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 765952002089 dihydropteroate synthase; Region: DHPS; TIGR01496 765952002090 substrate binding pocket [chemical binding]; other site 765952002091 dimer interface [polypeptide binding]; other site 765952002092 inhibitor binding site; inhibition site 765952002093 Uncharacterized conserved protein [Function unknown]; Region: COG1624 765952002094 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 765952002095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 765952002096 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 765952002097 pyruvate kinase; Provisional; Region: PRK05826 765952002098 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 765952002099 domain interfaces; other site 765952002100 active site 765952002101 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 765952002102 AMP-binding enzyme; Region: AMP-binding; cl15778 765952002103 acyl-CoA synthetase; Validated; Region: PRK06178 765952002104 C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973 765952002105 putative catalytic residues [active] 765952002106 putative catalytic loop [active] 765952002107 putative metal binding site [ion binding]; other site 765952002108 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 765952002109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002110 S-adenosylmethionine binding site [chemical binding]; other site 765952002111 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 765952002112 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 765952002113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 765952002114 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765952002115 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952002116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952002117 Transporter associated domain; Region: CorC_HlyC; cl08393 765952002118 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 765952002119 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 765952002120 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952002121 Sel1 repeat; Region: Sel1; cl02723 765952002122 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952002123 Sel1 repeat; Region: Sel1; cl02723 765952002124 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 765952002125 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 765952002126 nucleoside/Zn binding site; other site 765952002127 dimer interface [polypeptide binding]; other site 765952002128 catalytic motif [active] 765952002129 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 765952002130 adenylate kinase; Reviewed; Region: adk; PRK00279 765952002131 AMP-binding site [chemical binding]; other site 765952002132 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 765952002133 F-box domain; Region: F-box; cl02535 765952002134 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 765952002135 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 765952002136 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 765952002137 putative peptidoglycan binding site; other site 765952002138 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 765952002139 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 765952002140 active site 765952002141 substrate-binding site [chemical binding]; other site 765952002142 metal-binding site [ion binding] 765952002143 GTP binding site [chemical binding]; other site 765952002144 rod shape-determining protein MreB; Provisional; Region: PRK13927 765952002145 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 765952002146 ATP binding site [chemical binding]; other site 765952002147 profilin binding site; other site 765952002148 gelsolin binding site; other site 765952002149 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 765952002150 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 765952002151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952002152 ATP binding site [chemical binding]; other site 765952002153 putative Mg++ binding site [ion binding]; other site 765952002154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952002155 nucleotide binding region [chemical binding]; other site 765952002156 ATP-binding site [chemical binding]; other site 765952002157 trigger factor; Provisional; Region: tig; PRK01490 765952002158 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 765952002159 Clp protease; Region: CLP_protease; pfam00574 765952002160 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765952002161 oligomer interface [polypeptide binding]; other site 765952002162 active site residues [active] 765952002163 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 765952002164 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 765952002165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002166 Walker A motif; other site 765952002167 ATP binding site [chemical binding]; other site 765952002168 Walker B motif; other site 765952002169 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 765952002170 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 765952002171 catalytic core [active] 765952002172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952002173 Coenzyme A binding pocket [chemical binding]; other site 765952002174 intracellular protease, PfpI family; Region: PfpI; TIGR01382 765952002175 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 765952002176 proposed catalytic triad [active] 765952002177 conserved cys residue [active] 765952002178 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 765952002179 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 765952002180 putative DNA binding site [nucleotide binding]; other site 765952002181 putative homodimer interface [polypeptide binding]; other site 765952002182 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 765952002183 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 765952002184 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 765952002185 active site 765952002186 DNA binding site [nucleotide binding] 765952002187 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 765952002188 DNA binding site [nucleotide binding] 765952002189 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 765952002190 nucleotide binding site [chemical binding]; other site 765952002191 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 765952002192 catalytic center binding site [active] 765952002193 ATP binding site [chemical binding]; other site 765952002194 NeuB family; Region: NeuB; cl00496 765952002195 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 765952002196 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 765952002197 Walker A/P-loop; other site 765952002198 ATP binding site [chemical binding]; other site 765952002199 Q-loop/lid; other site 765952002200 ABC transporter signature motif; other site 765952002201 Walker B; other site 765952002202 D-loop; other site 765952002203 H-loop/switch region; other site 765952002204 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 765952002205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 765952002206 recombination factor protein RarA; Reviewed; Region: PRK13342 765952002207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002208 Walker A motif; other site 765952002209 ATP binding site [chemical binding]; other site 765952002210 Walker B motif; other site 765952002211 arginine finger; other site 765952002212 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 765952002213 Peptidase family M48; Region: Peptidase_M48; cl12018 765952002214 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952002215 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 765952002216 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 765952002217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952002218 active site 765952002219 motif I; other site 765952002220 motif II; other site 765952002221 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952002222 Transposase domain (DUF772); Region: DUF772; cl15789 765952002223 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002224 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002225 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002226 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952002227 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002228 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002229 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002230 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002231 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002232 ankyrin-like protein; Provisional; Region: PHA03095 765952002233 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002234 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002235 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002236 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002238 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952002239 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002240 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002241 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002242 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002243 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002244 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002245 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002246 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002247 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002250 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002252 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002253 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002254 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002255 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002256 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002257 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002258 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002259 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 765952002260 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 765952002261 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 765952002262 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 765952002263 amphipathic channel; other site 765952002264 Asn-Pro-Ala signature motifs; other site 765952002265 Phosphate-starvation-inducible E; Region: PsiE; cl01264 765952002266 F-box domain; Region: F-box; cl02535 765952002267 F-box domain; Region: F-box; cl02535 765952002268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002269 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 765952002270 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 765952002271 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 765952002272 RNB domain; Region: RNB; pfam00773 765952002273 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 765952002274 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952002275 RNA binding site [nucleotide binding]; other site 765952002276 Cytochrome c [Energy production and conversion]; Region: COG3258 765952002277 Cytochrome c; Region: Cytochrom_C; cl11414 765952002278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952002279 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952002280 substrate binding pocket [chemical binding]; other site 765952002281 membrane-bound complex binding site; other site 765952002282 hinge residues; other site 765952002283 Phospholipid methyltransferase; Region: PEMT; cl00763 765952002284 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 765952002285 homodimer interface [polypeptide binding]; other site 765952002286 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 765952002287 active site pocket [active] 765952002288 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002289 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002290 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002291 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002292 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002293 ankyrin repeat protein; Provisional; Region: PHA03100 765952002294 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002295 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002297 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002298 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002299 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002300 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002301 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002302 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002303 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002304 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952002305 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 765952002306 Cupin domain; Region: Cupin_2; cl09118 765952002307 Cupin domain; Region: Cupin_2; cl09118 765952002308 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 765952002309 fumarate hydratase; Reviewed; Region: fumC; PRK00485 765952002310 Class II fumarases; Region: Fumarase_classII; cd01362 765952002311 active site 765952002312 tetramer interface [polypeptide binding]; other site 765952002313 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952002314 RHS Repeat; Region: RHS_repeat; cl11982 765952002315 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952002316 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 765952002317 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 765952002318 active site 765952002319 Zn binding site [ion binding]; other site 765952002320 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 765952002321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952002322 active site 765952002323 phosphorylation site [posttranslational modification] 765952002324 intermolecular recognition site; other site 765952002325 dimerization interface [polypeptide binding]; other site 765952002326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002327 Walker A motif; other site 765952002328 ATP binding site [chemical binding]; other site 765952002329 Walker B motif; other site 765952002330 arginine finger; other site 765952002331 Helix-turn-helix domains; Region: HTH; cl00088 765952002332 sensory histidine kinase AtoS; Provisional; Region: PRK11360 765952002333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765952002334 dimer interface [polypeptide binding]; other site 765952002335 phosphorylation site [posttranslational modification] 765952002336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952002337 ATP binding site [chemical binding]; other site 765952002338 Mg2+ binding site [ion binding]; other site 765952002339 G-X-G motif; other site 765952002340 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 765952002341 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 765952002342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952002343 RNA binding surface [nucleotide binding]; other site 765952002344 Major royal jelly protein; Region: MRJP; pfam03022 765952002345 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 765952002346 endonuclease IV; Provisional; Region: PRK01060 765952002347 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 765952002348 AP (apurinic/apyrimidinic) site pocket; other site 765952002349 DNA interaction; other site 765952002350 Metal-binding active site; metal-binding site 765952002351 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 765952002352 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 765952002353 putative dimer interface [polypeptide binding]; other site 765952002354 putative anticodon binding site; other site 765952002355 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 765952002356 homodimer interface [polypeptide binding]; other site 765952002357 motif 1; other site 765952002358 motif 2; other site 765952002359 active site 765952002360 motif 3; other site 765952002361 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765952002362 Catalytic site [active] 765952002363 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 765952002364 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765952002365 Glycerate kinase family; Region: Gly_kinase; cl00841 765952002366 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 765952002367 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 765952002368 active site 765952002369 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 765952002370 Isochorismatase family; Region: Isochorismatase; pfam00857 765952002371 catalytic triad [active] 765952002372 metal binding site [ion binding]; metal-binding site 765952002373 conserved cis-peptide bond; other site 765952002374 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 765952002375 ArsC family; Region: ArsC; pfam03960 765952002376 putative ArsC-like catalytic residues; other site 765952002377 putative TRX-like catalytic residues [active] 765952002378 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 765952002379 Cation efflux family; Region: Cation_efflux; cl00316 765952002380 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 765952002381 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 765952002382 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 765952002383 Fe-S metabolism associated domain; Region: SufE; cl00951 765952002384 Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194 765952002385 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 765952002386 active site 765952002387 peptide chain release factor 2; Validated; Region: prfB; PRK00578 765952002388 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 765952002389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765952002390 dimerization interface [polypeptide binding]; other site 765952002391 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952002392 dimer interface [polypeptide binding]; other site 765952002393 putative CheW interface [polypeptide binding]; other site 765952002394 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 765952002395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765952002396 dimerization interface [polypeptide binding]; other site 765952002397 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952002398 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952002399 dimer interface [polypeptide binding]; other site 765952002400 putative CheW interface [polypeptide binding]; other site 765952002401 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 765952002402 active site 765952002403 multimer interface [polypeptide binding]; other site 765952002404 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 765952002405 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 765952002406 glutamine binding [chemical binding]; other site 765952002407 catalytic triad [active] 765952002408 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 765952002409 active site 765952002410 multimer interface [polypeptide binding]; other site 765952002411 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 765952002412 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 765952002413 tetramer interface [polypeptide binding]; other site 765952002414 active site 765952002415 Mg2+/Mn2+ binding site [ion binding]; other site 765952002416 malate synthase A; Region: malate_syn_A; TIGR01344 765952002417 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 765952002418 active site 765952002419 Ferritin-like domain; Region: Ferritin; pfam00210 765952002420 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 765952002421 dimerization interface [polypeptide binding]; other site 765952002422 DPS ferroxidase diiron center [ion binding]; other site 765952002423 ion pore; other site 765952002424 Dodecin; Region: Dodecin; cl01328 765952002425 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 765952002426 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 765952002427 putative tRNA-binding site [nucleotide binding]; other site 765952002428 B3/4 domain; Region: B3_4; cl11458 765952002429 tRNA synthetase B5 domain; Region: B5; cl08394 765952002430 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 765952002431 dimer interface [polypeptide binding]; other site 765952002432 motif 1; other site 765952002433 motif 3; other site 765952002434 motif 2; other site 765952002435 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 765952002436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952002437 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 765952002438 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765952002439 DNA binding site [nucleotide binding] 765952002440 active site 765952002441 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 765952002442 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 765952002443 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 765952002444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002445 NAD(P) binding site [chemical binding]; other site 765952002446 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 765952002447 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 765952002448 substrate-cofactor binding pocket; other site 765952002449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952002450 catalytic residue [active] 765952002451 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 765952002452 Domain interface; other site 765952002453 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 765952002454 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 765952002455 BON domain; Region: BON; cl02771 765952002456 BON domain; Region: BON; cl02771 765952002457 pyruvate dehydrogenase; Provisional; Region: PRK09124 765952002458 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 765952002459 PYR/PP interface [polypeptide binding]; other site 765952002460 dimer interface [polypeptide binding]; other site 765952002461 tetramer interface [polypeptide binding]; other site 765952002462 TPP binding site [chemical binding]; other site 765952002463 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 765952002464 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 765952002465 TPP-binding site [chemical binding]; other site 765952002466 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 765952002467 Protein of unknown function DUF72; Region: DUF72; cl00777 765952002468 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002469 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002470 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952002471 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 765952002472 RHS Repeat; Region: RHS_repeat; cl11982 765952002473 Transposase domain (DUF772); Region: DUF772; cl15789 765952002474 F-box domain; Region: F-box; cl02535 765952002475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 765952002476 FAD binding domain; Region: FAD_binding_4; pfam01565 765952002477 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 765952002478 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 765952002479 OsmC-like protein; Region: OsmC; cl00767 765952002480 mercuric reductase; Validated; Region: PRK06370 765952002481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952002482 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952002483 Succinylarginine dihydrolase; Region: AstB; cl01511 765952002484 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765952002485 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 765952002486 NAD(P) binding site [chemical binding]; other site 765952002487 catalytic residues [active] 765952002488 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 765952002489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765952002490 acetylornithine aminotransferase; Provisional; Region: PRK02627 765952002491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952002492 catalytic residue [active] 765952002493 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 765952002494 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 765952002495 metal binding site [ion binding]; metal-binding site 765952002496 dimer interface [polypeptide binding]; other site 765952002497 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952002498 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 765952002499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952002501 binding surface 765952002502 TPR motif; other site 765952002503 TPR repeat; Region: TPR_11; pfam13414 765952002504 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952002505 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 765952002506 putative binding surface; other site 765952002507 active site 765952002508 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 765952002509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952002510 ATP binding site [chemical binding]; other site 765952002511 Mg2+ binding site [ion binding]; other site 765952002512 G-X-G motif; other site 765952002513 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952002514 Response regulator receiver domain; Region: Response_reg; pfam00072 765952002515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952002516 active site 765952002517 phosphorylation site [posttranslational modification] 765952002518 intermolecular recognition site; other site 765952002519 dimerization interface [polypeptide binding]; other site 765952002520 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 765952002521 substrate binding site [chemical binding]; other site 765952002522 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765952002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952002524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952002525 putative substrate translocation pore; other site 765952002526 DNA primase; Validated; Region: dnaG; PRK05667 765952002527 CHC2 zinc finger; Region: zf-CHC2; cl15369 765952002528 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 765952002529 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 765952002530 active site 765952002531 metal binding site [ion binding]; metal-binding site 765952002532 interdomain interaction site; other site 765952002533 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 765952002534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002535 active site 765952002536 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 765952002537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952002538 FeS/SAM binding site; other site 765952002539 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 765952002540 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 765952002541 GIY-YIG motif/motif A; other site 765952002542 active site 765952002543 catalytic site [active] 765952002544 putative DNA binding site [nucleotide binding]; other site 765952002545 metal binding site [ion binding]; metal-binding site 765952002546 UvrB/uvrC motif; Region: UVR; pfam02151 765952002547 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 765952002548 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 765952002549 DNA binding site [nucleotide binding] 765952002550 ResB-like family; Region: ResB; pfam05140 765952002551 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 765952002552 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 765952002553 TPP-binding site [chemical binding]; other site 765952002554 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 765952002555 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 765952002556 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765952002557 E3 interaction surface; other site 765952002558 lipoyl attachment site [posttranslational modification]; other site 765952002559 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 765952002560 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 765952002561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952002563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952002564 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002565 Transposase domain (DUF772); Region: DUF772; cl15789 765952002566 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765952002567 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 765952002568 NAD(P) binding site [chemical binding]; other site 765952002569 catalytic residues [active] 765952002570 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 765952002571 Domain of unknown function (DUF296); Region: DUF296; cl00720 765952002572 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 765952002573 classical (c) SDRs; Region: SDR_c; cd05233 765952002574 NAD(P) binding site [chemical binding]; other site 765952002575 active site 765952002576 Major royal jelly protein; Region: MRJP; pfam03022 765952002577 ATP12 chaperone protein; Region: ATP12; cl02228 765952002578 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 765952002579 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 765952002580 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765952002581 catalytic loop [active] 765952002582 iron binding site [ion binding]; other site 765952002583 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 765952002584 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 765952002585 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 765952002586 oligomerization interface [polypeptide binding]; other site 765952002587 active site 765952002588 NAD+ binding site [chemical binding]; other site 765952002589 chromosomal replication initiation protein; Provisional; Region: PRK12422 765952002590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002591 Walker A motif; other site 765952002592 ATP binding site [chemical binding]; other site 765952002593 Walker B motif; other site 765952002594 arginine finger; other site 765952002595 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 765952002596 DnaA box-binding interface [nucleotide binding]; other site 765952002597 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 765952002598 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 765952002599 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952002600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952002601 active site 765952002602 ATP binding site [chemical binding]; other site 765952002603 substrate binding site [chemical binding]; other site 765952002604 activation loop (A-loop); other site 765952002605 Uncharacterized conserved protein [Function unknown]; Region: COG1262 765952002606 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 765952002607 Low molecular weight phosphatase family; Region: LMWPc; cd00115 765952002608 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 765952002609 active site 765952002610 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 765952002611 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765952002612 inhibitor-cofactor binding pocket; inhibition site 765952002613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952002614 catalytic residue [active] 765952002615 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765952002616 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 765952002617 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952002618 Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ThrS; COG0441 765952002619 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 765952002620 motif 1; other site 765952002621 dimer interface [polypeptide binding]; other site 765952002622 active site 765952002623 motif 2; other site 765952002624 motif 3; other site 765952002625 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 765952002626 anticodon binding site; other site 765952002627 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 765952002628 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 765952002629 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 765952002630 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 765952002631 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 765952002632 23S rRNA binding site [nucleotide binding]; other site 765952002633 L21 binding site [polypeptide binding]; other site 765952002634 L13 binding site [polypeptide binding]; other site 765952002635 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 765952002636 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 765952002637 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 765952002638 dimer interface [polypeptide binding]; other site 765952002639 motif 1; other site 765952002640 active site 765952002641 motif 2; other site 765952002642 motif 3; other site 765952002643 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765952002644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952002645 RNA binding surface [nucleotide binding]; other site 765952002646 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 765952002647 active site 765952002648 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765952002649 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 765952002650 putative active site [active] 765952002651 AAA domain; Region: AAA_26; pfam13500 765952002652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952002653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952002654 DRTGG domain; Region: DRTGG; cl12147 765952002655 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 765952002656 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 765952002657 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 765952002658 nudix motif; other site 765952002659 hexaprenyldihydroxybenzoate methyltransferase; Region: PLN02396 765952002660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002661 S-adenosylmethionine binding site [chemical binding]; other site 765952002662 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 765952002663 dimer interface [polypeptide binding]; other site 765952002664 active site 765952002665 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 765952002666 Ligand Binding Site [chemical binding]; other site 765952002667 Molecular Tunnel; other site 765952002668 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 765952002669 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 765952002670 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765952002671 HIGH motif; other site 765952002672 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765952002673 active site 765952002674 KMSKS motif; other site 765952002675 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 765952002676 tRNA binding surface [nucleotide binding]; other site 765952002677 anticodon binding site; other site 765952002678 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 765952002679 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952002680 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952002681 active site 765952002682 ATP binding site [chemical binding]; other site 765952002683 substrate binding site [chemical binding]; other site 765952002684 activation loop (A-loop); other site 765952002685 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952002686 substrate binding site [chemical binding]; other site 765952002687 activation loop (A-loop); other site 765952002688 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348 765952002689 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765952002690 MgtE intracellular N domain; Region: MgtE_N; cl15244 765952002691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765952002692 Divalent cation transporter; Region: MgtE; cl00786 765952002693 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 765952002694 active site 765952002695 catalytic residues [active] 765952002696 metal binding site [ion binding]; metal-binding site 765952002697 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 765952002698 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952002699 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952002700 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952002701 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002702 BON domain; Region: BON; cl02771 765952002703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002704 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 765952002705 Putative glucoamylase; Region: Glycoamylase; pfam10091 765952002706 Putative carbohydrate binding domain; Region: CBM_X; cl05621 765952002707 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 765952002708 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 765952002709 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 765952002710 Putative carbohydrate binding domain; Region: CBM_X; cl05621 765952002711 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 765952002712 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 765952002713 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 765952002714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002715 S-adenosylmethionine binding site [chemical binding]; other site 765952002716 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952002717 putative catalytic site [active] 765952002718 putative metal binding site [ion binding]; other site 765952002719 putative phosphate binding site [ion binding]; other site 765952002720 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 765952002721 UDP-glucose-4-epimerase; Region: galE; TIGR01179 765952002722 NAD binding site [chemical binding]; other site 765952002723 homodimer interface [polypeptide binding]; other site 765952002724 active site 765952002725 substrate binding site [chemical binding]; other site 765952002726 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 765952002727 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952002728 F-box domain; Region: F-box; cl02535 765952002729 MazG family protein; Region: mazG; TIGR00444 765952002730 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 765952002731 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 765952002732 MepB protein; Region: MepB; cl01985 765952002733 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 765952002734 dimerization interface [polypeptide binding]; other site 765952002735 metal binding site [ion binding]; metal-binding site 765952002736 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 765952002737 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 765952002739 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 765952002740 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 765952002741 Divergent AAA domain; Region: AAA_4; pfam04326 765952002742 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 765952002743 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 765952002744 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765952002745 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765952002746 ring oligomerisation interface [polypeptide binding]; other site 765952002747 ATP/Mg binding site [chemical binding]; other site 765952002748 stacking interactions; other site 765952002749 hinge regions; other site 765952002750 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 765952002751 oligomerisation interface [polypeptide binding]; other site 765952002752 mobile loop; other site 765952002753 roof hairpin; other site 765952002754 oligoendopeptidase F; Region: pepF; TIGR00181 765952002755 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 765952002756 active site 765952002757 Zn binding site [ion binding]; other site 765952002758 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 765952002759 dimerization domain swap beta strand [polypeptide binding]; other site 765952002760 regulatory protein interface [polypeptide binding]; other site 765952002761 active site 765952002762 regulatory phosphorylation site [posttranslational modification]; other site 765952002763 Bifunctional nuclease; Region: DNase-RNase; cl00553 765952002764 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 765952002765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765952002766 active site 765952002767 dimer interface [polypeptide binding]; other site 765952002768 Uncharacterized conserved protein [Function unknown]; Region: COG0327 765952002769 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 765952002770 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 765952002771 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 765952002772 active site 765952002773 HIGH motif; other site 765952002774 dimer interface [polypeptide binding]; other site 765952002775 KMSKS motif; other site 765952002776 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 765952002777 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 765952002778 IHF - DNA interface [nucleotide binding]; other site 765952002779 IHF dimer interface [polypeptide binding]; other site 765952002780 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 765952002781 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 765952002782 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 765952002783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765952002784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952002785 Walker A/P-loop; other site 765952002786 ATP binding site [chemical binding]; other site 765952002787 Q-loop/lid; other site 765952002788 ABC transporter signature motif; other site 765952002789 Walker B; other site 765952002790 D-loop; other site 765952002791 H-loop/switch region; other site 765952002792 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 765952002793 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 765952002794 GatB domain; Region: GatB_Yqey; cl11497 765952002795 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 765952002796 Amidase; Region: Amidase; cl11426 765952002797 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 765952002798 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 765952002799 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 765952002800 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765952002801 DNA binding site [nucleotide binding] 765952002802 active site 765952002803 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 765952002804 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 765952002805 active site 765952002806 homodimer interface [polypeptide binding]; other site 765952002807 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952002808 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 765952002809 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952002810 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765952002811 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 765952002812 ATP-grasp domain; Region: ATP-grasp_4; cl03087 765952002813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002814 active site 765952002815 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 765952002816 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 765952002817 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 765952002818 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 765952002819 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 765952002820 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765952002821 dimer interface [polypeptide binding]; other site 765952002822 ssDNA binding site [nucleotide binding]; other site 765952002823 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765952002824 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 765952002825 anti sigma factor interaction site; other site 765952002826 regulatory phosphorylation site [posttranslational modification]; other site 765952002827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952002828 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 765952002829 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 765952002830 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 765952002831 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952002832 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 765952002833 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 765952002834 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 765952002835 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 765952002836 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 765952002837 active site 765952002838 (T/H)XGH motif; other site 765952002839 Oligomerisation domain; Region: Oligomerisation; cl00519 765952002840 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 765952002841 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 765952002842 dimer interface [polypeptide binding]; other site 765952002843 active site 765952002844 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 765952002845 active site 765952002846 Ap4A binding cleft/pocket [chemical binding]; other site 765952002847 P4 phosphate binding site; other site 765952002848 nudix motif; other site 765952002849 putative P2/P3 phosphate binding site [ion binding]; other site 765952002850 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 765952002851 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765952002852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952002853 catalytic residue [active] 765952002854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002855 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 765952002856 AAA domain; Region: AAA_26; pfam13500 765952002857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952002858 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765952002859 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 765952002860 inhibitor-cofactor binding pocket; inhibition site 765952002861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952002862 catalytic residue [active] 765952002863 Flavin Reductases; Region: FlaRed; cl00801 765952002864 F-box domain; Region: F-box; cl02535 765952002865 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 765952002866 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 765952002867 NADP binding site [chemical binding]; other site 765952002868 homopentamer interface [polypeptide binding]; other site 765952002869 substrate binding site [chemical binding]; other site 765952002870 active site 765952002871 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 765952002872 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 765952002873 putative ribose interaction site [chemical binding]; other site 765952002874 putative ADP binding site [chemical binding]; other site 765952002875 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 765952002876 Ras interaction site [polypeptide binding]; other site 765952002877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952002878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952002879 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 765952002880 active site 765952002881 ADP/pyrophosphate binding site [chemical binding]; other site 765952002882 dimerization interface [polypeptide binding]; other site 765952002883 allosteric effector site; other site 765952002884 fructose-1,6-bisphosphate binding site; other site 765952002885 Peptidase family M48; Region: Peptidase_M48; cl12018 765952002886 LemA family; Region: LemA; cl00742 765952002887 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 765952002888 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 765952002889 transmembrane helices; other site 765952002890 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 765952002891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002892 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 765952002893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765952002894 non-specific DNA binding site [nucleotide binding]; other site 765952002895 salt bridge; other site 765952002896 sequence-specific DNA binding site [nucleotide binding]; other site 765952002897 Protein of unknown function, DUF488; Region: DUF488; cl01246 765952002898 Ubiquitin family; Region: ubiquitin; pfam00240 765952002899 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 765952002900 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952002901 active site 765952002902 DNA binding site [nucleotide binding] 765952002903 Int/Topo IB signature motif; other site 765952002904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952002905 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 765952002906 TfoX N-terminal domain; Region: TfoX_N; cl01167 765952002907 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 765952002908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002909 Transposase [DNA replication, recombination, and repair]; Region: COG5433 765952002910 Transposase [DNA replication, recombination, and repair]; Region: COG5433 765952002911 F-box domain; Region: F-box; cl02535 765952002912 hypothetical protein; Provisional; Region: PRK06154 765952002913 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 765952002914 putative active site [active] 765952002915 putative nucleic acid binding site [nucleotide binding]; other site 765952002916 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 765952002917 NTP binding site [chemical binding]; other site 765952002918 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 765952002919 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 765952002920 RNA/DNA binding site [nucleotide binding]; other site 765952002921 RRM dimerization site [polypeptide binding]; other site 765952002922 SEC-C motif; Region: SEC-C; pfam02810 765952002923 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 765952002924 Ligand Binding Site [chemical binding]; other site 765952002925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002926 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 765952002927 Walker A motif; other site 765952002928 ATP binding site [chemical binding]; other site 765952002929 Walker B motif; other site 765952002930 arginine finger; other site 765952002931 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 765952002932 Lumazine binding domain; Region: Lum_binding; pfam00677 765952002933 Lumazine binding domain; Region: Lum_binding; pfam00677 765952002934 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 765952002935 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 765952002936 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 765952002937 dimerization interface [polypeptide binding]; other site 765952002938 active site 765952002939 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 765952002940 homopentamer interface [polypeptide binding]; other site 765952002941 active site 765952002942 DoxX; Region: DoxX; cl00976 765952002943 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952002944 Sel1 repeat; Region: Sel1; cl02723 765952002945 Sel1 repeat; Region: Sel1; cl02723 765952002946 Sel1 repeat; Region: Sel1; cl02723 765952002947 Sel1 repeat; Region: Sel1; cl02723 765952002948 Sel1 repeat; Region: Sel1; cl02723 765952002949 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 765952002950 Sel1 repeat; Region: Sel1; cl02723 765952002951 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952002952 Sel1 repeat; Region: Sel1; cl02723 765952002953 Sel1 repeat; Region: Sel1; cl02723 765952002954 Sel1 repeat; Region: Sel1; cl02723 765952002955 Sel1 repeat; Region: Sel1; cl02723 765952002956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952002957 TPR motif; other site 765952002958 TPR repeat; Region: TPR_11; pfam13414 765952002959 binding surface 765952002960 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 765952002961 FAD binding domain; Region: FAD_binding_4; pfam01565 765952002962 F-box domain; Region: F-box; cl02535 765952002963 hypothetical protein; Provisional; Region: PRK06154 765952002964 F-box domain; Region: F-box; cl02535 765952002965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952002966 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 765952002967 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 765952002968 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 765952002969 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 765952002970 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 765952002971 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 765952002972 RNA binding site [nucleotide binding]; other site 765952002973 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765952002974 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 765952002975 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 765952002976 catalytic residues [active] 765952002977 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952002978 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952002979 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 765952002980 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 765952002981 Ligand Binding Site [chemical binding]; other site 765952002982 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 765952002983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952002984 FeS/SAM binding site; other site 765952002985 malate dehydrogenase; Provisional; Region: PRK05442 765952002986 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 765952002987 NAD(P) binding site [chemical binding]; other site 765952002988 dimer interface [polypeptide binding]; other site 765952002989 malate binding site [chemical binding]; other site 765952002990 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 765952002991 Citrate synthase; Region: Citrate_synt; pfam00285 765952002992 oxalacetate binding site [chemical binding]; other site 765952002993 citrylCoA binding site [chemical binding]; other site 765952002994 coenzyme A binding site [chemical binding]; other site 765952002995 catalytic triad [active] 765952002996 FAD dependent oxidoreductase; Region: DAO; pfam01266 765952002997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002998 CAAX protease self-immunity; Region: Abi; cl00558 765952002999 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 765952003000 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 765952003001 substrate binding site [chemical binding]; other site 765952003002 acetyl-CoA synthetase; Provisional; Region: PRK00174 765952003003 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 765952003004 AMP-binding enzyme; Region: AMP-binding; cl15778 765952003005 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003006 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 765952003007 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 765952003008 catalytic motif [active] 765952003009 Zn binding site [ion binding]; other site 765952003010 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 765952003011 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 765952003012 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952003013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952003014 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 765952003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003016 S-adenosylmethionine binding site [chemical binding]; other site 765952003017 Protein of unknown function (DUF423); Region: DUF423; cl01008 765952003018 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 765952003019 dimer interface [polypeptide binding]; other site 765952003020 ADP-ribose binding site [chemical binding]; other site 765952003021 active site 765952003022 nudix motif; other site 765952003023 metal binding site [ion binding]; metal-binding site 765952003024 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 765952003025 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952003026 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 765952003027 Ligand Binding Site [chemical binding]; other site 765952003028 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 765952003029 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 765952003030 E-class dimer interface [polypeptide binding]; other site 765952003031 P-class dimer interface [polypeptide binding]; other site 765952003032 active site 765952003033 Cu2+ binding site [ion binding]; other site 765952003034 Zn2+ binding site [ion binding]; other site 765952003035 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 765952003036 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 765952003037 nucleotide binding pocket [chemical binding]; other site 765952003038 K-X-D-G motif; other site 765952003039 catalytic site [active] 765952003040 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 765952003041 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 765952003042 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 765952003043 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 765952003044 Dimer interface [polypeptide binding]; other site 765952003045 BRCT sequence motif; other site 765952003046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952003047 binding surface 765952003048 TPR motif; other site 765952003049 TPR repeat; Region: TPR_11; pfam13414 765952003050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003051 TPR motif; other site 765952003052 binding surface 765952003053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952003054 TPR motif; other site 765952003055 binding surface 765952003056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003057 binding surface 765952003058 TPR motif; other site 765952003059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003060 binding surface 765952003061 TPR motif; other site 765952003062 TPR repeat; Region: TPR_11; pfam13414 765952003063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003064 binding surface 765952003065 TPR motif; other site 765952003066 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 765952003067 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 765952003068 Protein of unknown function (DUF721); Region: DUF721; cl02324 765952003069 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 765952003070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952003071 ATP binding site [chemical binding]; other site 765952003072 Mg2+ binding site [ion binding]; other site 765952003073 G-X-G motif; other site 765952003074 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 765952003075 anchoring element; other site 765952003076 dimer interface [polypeptide binding]; other site 765952003077 ATP binding site [chemical binding]; other site 765952003078 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 765952003079 active site 765952003080 putative metal-binding site [ion binding]; other site 765952003081 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 765952003082 DNA gyrase subunit A; Validated; Region: PRK05560 765952003083 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 765952003084 CAP-like domain; other site 765952003085 active site 765952003086 primary dimer interface [polypeptide binding]; other site 765952003087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003093 thymidylate kinase; Validated; Region: tmk; PRK00698 765952003094 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 765952003095 TMP-binding site; other site 765952003096 ATP-binding site [chemical binding]; other site 765952003097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952003098 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 765952003099 Walker A motif; other site 765952003100 ATP binding site [chemical binding]; other site 765952003101 Walker B motif; other site 765952003102 arginine finger; other site 765952003103 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 765952003104 Low affinity iron permease; Region: Iron_permease; cl12096 765952003105 Fibronectin type III-like domain; Region: Fn3-like; cl15273 765952003106 Fibronectin type III-like domain; Region: Fn3-like; cl15273 765952003107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003108 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 765952003109 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 765952003110 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 765952003111 transaminase; Validated; Region: PRK07324 765952003112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765952003113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952003114 homodimer interface [polypeptide binding]; other site 765952003115 catalytic residue [active] 765952003116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 765952003117 YheO-like PAS domain; Region: PAS_6; pfam08348 765952003118 Helix-turn-helix domains; Region: HTH; cl00088 765952003119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952003120 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 765952003121 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 765952003122 HflX GTPase family; Region: HflX; cd01878 765952003123 G1 box; other site 765952003124 GTP/Mg2+ binding site [chemical binding]; other site 765952003125 Switch I region; other site 765952003126 G2 box; other site 765952003127 G3 box; other site 765952003128 Switch II region; other site 765952003129 G4 box; other site 765952003130 G5 box; other site 765952003131 hypothetical protein; Reviewed; Region: PRK00024 765952003132 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 765952003133 MPN+ (JAMM) motif; other site 765952003134 Zinc-binding site [ion binding]; other site 765952003135 Protein of unknown function (DUF3638); Region: DUF3638; pfam12340 765952003136 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 765952003137 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 765952003138 catalytic triad [active] 765952003139 amino acid transporter; Region: 2A0306; TIGR00909 765952003140 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952003141 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952003142 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952003143 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952003144 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952003145 Protein of unknown function (DUF3638); Region: DUF3638; pfam12340 765952003146 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003147 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 765952003148 active site 765952003149 ATP binding site [chemical binding]; other site 765952003150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 765952003151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952003152 Coenzyme A binding pocket [chemical binding]; other site 765952003153 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 765952003154 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003155 active site 765952003156 DNA binding site [nucleotide binding] 765952003157 Int/Topo IB signature motif; other site 765952003158 Domain of unknown function (DUF927); Region: DUF927; cl12098 765952003159 CHC2 zinc finger; Region: zf-CHC2; cl15369 765952003160 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 765952003161 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 765952003162 active site 765952003163 metal binding site [ion binding]; metal-binding site 765952003164 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 765952003165 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 765952003166 putative active site [active] 765952003167 putative substrate binding site [chemical binding]; other site 765952003168 ATP binding site [chemical binding]; other site 765952003169 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 765952003170 Helix-turn-helix domains; Region: HTH; cl00088 765952003171 EVE domain; Region: EVE; cl00728 765952003172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952003173 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 765952003174 putative dimer interface [polypeptide binding]; other site 765952003175 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 765952003176 active site 765952003177 putative catalytic site [active] 765952003178 DNA binding site [nucleotide binding] 765952003179 putative phosphate binding site [ion binding]; other site 765952003180 metal binding site A [ion binding]; metal-binding site 765952003181 AP binding site [nucleotide binding]; other site 765952003182 metal binding site B [ion binding]; metal-binding site 765952003183 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 765952003184 hydrophobic ligand binding site; other site 765952003185 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 765952003186 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 765952003187 FAD binding pocket [chemical binding]; other site 765952003188 conserved FAD binding motif [chemical binding]; other site 765952003189 phosphate binding motif [ion binding]; other site 765952003190 beta-alpha-beta structure motif; other site 765952003191 NAD binding pocket [chemical binding]; other site 765952003192 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952003193 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 765952003194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003195 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952003196 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 765952003197 putative active site [active] 765952003198 putative metal binding site [ion binding]; other site 765952003199 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952003200 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 765952003201 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 765952003202 putative active site [active] 765952003203 putative substrate binding site [chemical binding]; other site 765952003204 ATP binding site [chemical binding]; other site 765952003205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003206 binding surface 765952003207 Tetratricopeptide repeat; Region: TPR_16; pfam13432 765952003208 TPR motif; other site 765952003209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003210 TPR motif; other site 765952003211 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 765952003212 binding surface 765952003213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952003214 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 765952003215 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952003216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003217 S-adenosylmethionine binding site [chemical binding]; other site 765952003218 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 765952003219 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 765952003220 malonyl-CoA binding site [chemical binding]; other site 765952003221 dimer interface [polypeptide binding]; other site 765952003222 active site 765952003223 product binding site; other site 765952003224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003226 Family description; Region: UvrD_C_2; cl15862 765952003227 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 765952003228 Sulfate transporter family; Region: Sulfate_transp; cl15842 765952003229 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 765952003230 active site clefts [active] 765952003231 zinc binding site [ion binding]; other site 765952003232 dimer interface [polypeptide binding]; other site 765952003233 magnesium-transporting ATPase; Provisional; Region: PRK15122 765952003234 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 765952003235 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952003236 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 765952003237 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952003238 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 765952003239 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 765952003240 zinc binding site [ion binding]; other site 765952003241 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 765952003242 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 765952003243 classical (c) SDRs; Region: SDR_c; cd05233 765952003244 NAD(P) binding site [chemical binding]; other site 765952003245 active site 765952003246 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 765952003247 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 765952003248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952003249 active site 765952003250 ATP binding site [chemical binding]; other site 765952003251 substrate binding site [chemical binding]; other site 765952003252 activation loop (A-loop); other site 765952003253 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765952003254 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 765952003255 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 765952003256 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 765952003257 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765952003258 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765952003259 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 765952003260 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 765952003261 NADP binding site [chemical binding]; other site 765952003262 dimer interface [polypeptide binding]; other site 765952003263 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 765952003264 MgtC family; Region: MgtC; pfam02308 765952003265 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952003266 putative catalytic site [active] 765952003267 putative metal binding site [ion binding]; other site 765952003268 putative phosphate binding site [ion binding]; other site 765952003269 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 765952003270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952003271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 765952003272 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 765952003273 dimer interface [polypeptide binding]; other site 765952003274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952003275 metal binding site [ion binding]; metal-binding site 765952003276 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 765952003277 active site 765952003278 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 765952003279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952003280 Coenzyme A binding pocket [chemical binding]; other site 765952003281 biotin synthase; Region: bioB; TIGR00433 765952003282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003283 FeS/SAM binding site; other site 765952003284 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 765952003285 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 765952003286 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952003287 active site 765952003288 metal binding site [ion binding]; metal-binding site 765952003289 DNA binding site [nucleotide binding] 765952003290 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 765952003291 AAA domain; Region: AAA_27; pfam13514 765952003292 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 765952003293 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 765952003294 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 765952003295 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 765952003296 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 765952003297 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 765952003298 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 765952003299 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 765952003300 putative active site [active] 765952003301 catalytic residue [active] 765952003302 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 765952003303 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 765952003304 5S rRNA interface [nucleotide binding]; other site 765952003305 CTC domain interface [polypeptide binding]; other site 765952003306 L16 interface [polypeptide binding]; other site 765952003307 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 765952003308 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 765952003309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952003310 active site 765952003311 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 765952003312 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 765952003313 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952003314 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003315 active site 765952003316 DNA binding site [nucleotide binding] 765952003317 Int/Topo IB signature motif; other site 765952003318 F-box domain; Region: F-box; cl02535 765952003319 Transposase domain (DUF772); Region: DUF772; cl15789 765952003320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952003321 TraU protein; Region: TraU; cl06067 765952003322 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 765952003323 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952003324 Fic/DOC family; Region: Fic; cl00960 765952003325 Antitoxin ParD; Region: ParD; pfam09386 765952003326 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952003327 metal binding site [ion binding]; metal-binding site 765952003328 Archaeal ATPase; Region: Arch_ATPase; pfam01637 765952003329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003330 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 765952003331 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 765952003332 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 765952003333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003334 S-adenosylmethionine binding site [chemical binding]; other site 765952003335 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765952003336 MgtE intracellular N domain; Region: MgtE_N; cl15244 765952003337 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765952003338 Divalent cation transporter; Region: MgtE; cl00786 765952003339 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 765952003340 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 765952003341 G1 box; other site 765952003342 putative GEF interaction site [polypeptide binding]; other site 765952003343 GTP/Mg2+ binding site [chemical binding]; other site 765952003344 Switch I region; other site 765952003345 G2 box; other site 765952003346 G3 box; other site 765952003347 Switch II region; other site 765952003348 G4 box; other site 765952003349 G5 box; other site 765952003350 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 765952003351 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 765952003352 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003353 active site 765952003354 ATP binding site [chemical binding]; other site 765952003355 substrate binding site [chemical binding]; other site 765952003356 activation loop (A-loop); other site 765952003357 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952003358 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003359 active site 765952003360 ATP binding site [chemical binding]; other site 765952003361 substrate binding site [chemical binding]; other site 765952003362 activation loop (A-loop); other site 765952003363 F-box domain; Region: F-box; cl02535 765952003364 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952003365 structural tetrad; other site 765952003366 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 765952003367 Ligand binding site; other site 765952003368 oligomer interface; other site 765952003369 CTP synthetase; Validated; Region: pyrG; PRK05380 765952003370 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 765952003371 active site 765952003372 UTP binding site [chemical binding]; other site 765952003373 Catalytic site [active] 765952003374 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 765952003375 active site 765952003376 putative oxyanion hole; other site 765952003377 catalytic triad [active] 765952003378 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 765952003379 EVE domain; Region: EVE; cl00728 765952003380 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 765952003381 homotrimer interaction site [polypeptide binding]; other site 765952003382 putative active site [active] 765952003383 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 765952003384 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 765952003385 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 765952003386 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 765952003387 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 765952003388 putative active site [active] 765952003389 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 765952003390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003391 FeS/SAM binding site; other site 765952003392 HemN C-terminal domain; Region: HemN_C; pfam06969 765952003393 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 765952003394 Predicted methyltransferases [General function prediction only]; Region: COG0313 765952003395 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 765952003396 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 765952003397 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 765952003398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952003399 motif II; other site 765952003400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952003401 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952003402 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 765952003403 NeuB family; Region: NeuB; cl00496 765952003404 SAF domain; Region: SAF; cl00555 765952003405 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 765952003406 ligand binding site; other site 765952003407 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 765952003408 active site 765952003409 DNA polymerase IV; Validated; Region: PRK02406 765952003410 DNA binding site [nucleotide binding] 765952003411 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 765952003412 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765952003413 dimer interface [polypeptide binding]; other site 765952003414 ssDNA binding site [nucleotide binding]; other site 765952003415 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765952003416 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 765952003417 Tir chaperone protein (CesT) family; Region: CesT; cl08444 765952003418 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 765952003419 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 765952003420 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 765952003421 active site 765952003422 catalytic site [active] 765952003423 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 765952003424 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 765952003425 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 765952003426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952003427 Walker A motif; other site 765952003428 ATP binding site [chemical binding]; other site 765952003429 Walker B motif; other site 765952003430 arginine finger; other site 765952003431 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 765952003432 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 765952003433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003434 S-adenosylmethionine binding site [chemical binding]; other site 765952003435 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 765952003436 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 765952003437 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952003438 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 765952003439 heme-binding site [chemical binding]; other site 765952003440 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 765952003441 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765952003442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003443 FeS/SAM binding site; other site 765952003444 glycogen branching enzyme; Provisional; Region: PRK05402 765952003445 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 765952003446 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 765952003447 active site 765952003448 catalytic site [active] 765952003449 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 765952003450 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 765952003451 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 765952003452 ATP binding site [chemical binding]; other site 765952003453 Mg++ binding site [ion binding]; other site 765952003454 motif III; other site 765952003455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952003456 nucleotide binding region [chemical binding]; other site 765952003457 ATP-binding site [chemical binding]; other site 765952003458 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952003459 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 765952003460 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 765952003461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 765952003462 AlkA N-terminal domain; Region: AlkA_N; cl05528 765952003463 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 765952003464 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765952003465 minor groove reading motif; other site 765952003466 helix-hairpin-helix signature motif; other site 765952003467 substrate binding pocket [chemical binding]; other site 765952003468 active site 765952003469 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 765952003470 MatE; Region: MatE; cl10513 765952003471 MatE; Region: MatE; cl10513 765952003472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952003473 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 765952003474 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003475 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 765952003476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952003477 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 765952003478 putative peptidase; Provisional; Region: PRK14575 765952003479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952003480 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 765952003481 iron-sulfur cluster [ion binding]; other site 765952003482 [2Fe-2S] cluster binding site [ion binding]; other site 765952003483 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 765952003484 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 765952003485 30S subunit binding site; other site 765952003486 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 765952003487 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 765952003488 radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X 765952003489 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 765952003490 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 765952003491 dimer interface [polypeptide binding]; other site 765952003492 putative anticodon binding site; other site 765952003493 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 765952003494 motif 1; other site 765952003495 active site 765952003496 motif 2; other site 765952003497 motif 3; other site 765952003498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003501 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 765952003502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003503 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 765952003504 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 765952003505 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 765952003506 MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397 765952003507 4Fe-4S binding domain; Region: Fer4; cl02805 765952003508 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 765952003509 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952003510 active site 765952003511 HIGH motif; other site 765952003512 nucleotide binding site [chemical binding]; other site 765952003513 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 765952003514 KMSKS motif; other site 765952003515 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765952003516 tRNA binding surface [nucleotide binding]; other site 765952003517 anticodon binding site; other site 765952003518 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765952003519 putative acyl-acceptor binding pocket; other site 765952003520 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 765952003521 AMP-binding enzyme; Region: AMP-binding; cl15778 765952003522 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765952003523 active site residue [active] 765952003524 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 765952003525 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 765952003526 putative active site [active] 765952003527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003528 Bacterial SH3 domain; Region: SH3_3; cl02551 765952003529 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 765952003530 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 765952003531 active site 765952003532 Helix-turn-helix domains; Region: HTH; cl00088 765952003533 LexA repressor; Validated; Region: PRK00215 765952003534 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 765952003535 Catalytic site [active] 765952003536 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 765952003537 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 765952003538 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 765952003539 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 765952003540 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003541 Walker A/P-loop; other site 765952003542 ATP binding site [chemical binding]; other site 765952003543 Q-loop/lid; other site 765952003544 ABC transporter signature motif; other site 765952003545 Walker B; other site 765952003546 D-loop; other site 765952003547 H-loop/switch region; other site 765952003548 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 765952003549 active site 765952003550 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 765952003551 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952003552 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 765952003553 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 765952003554 NIMA-related protein kinase; Provisional; Region: PTZ00266 765952003555 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 765952003556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952003558 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952003559 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952003560 putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142 765952003561 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952003562 dimer interface [polypeptide binding]; other site 765952003563 putative CheW interface [polypeptide binding]; other site 765952003564 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 765952003565 putative binding surface; other site 765952003566 active site 765952003567 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 765952003568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952003569 ATP binding site [chemical binding]; other site 765952003570 Mg2+ binding site [ion binding]; other site 765952003571 G-X-G motif; other site 765952003572 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952003573 Response regulator receiver domain; Region: Response_reg; pfam00072 765952003574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952003575 active site 765952003576 phosphorylation site [posttranslational modification] 765952003577 intermolecular recognition site; other site 765952003578 dimerization interface [polypeptide binding]; other site 765952003579 Response regulator receiver domain; Region: Response_reg; pfam00072 765952003580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952003581 active site 765952003582 phosphorylation site [posttranslational modification] 765952003583 intermolecular recognition site; other site 765952003584 dimerization interface [polypeptide binding]; other site 765952003585 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 765952003586 cyclase homology domain; Region: CHD; cd07302 765952003587 nucleotidyl binding site; other site 765952003588 metal binding site [ion binding]; metal-binding site 765952003589 dimer interface [polypeptide binding]; other site 765952003590 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952003591 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 765952003592 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952003593 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952003594 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765952003595 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952003596 Walker A/P-loop; other site 765952003597 ATP binding site [chemical binding]; other site 765952003598 Q-loop/lid; other site 765952003599 ABC transporter signature motif; other site 765952003600 Walker B; other site 765952003601 D-loop; other site 765952003602 H-loop/switch region; other site 765952003603 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765952003604 DevC protein; Region: devC; TIGR01185 765952003605 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 765952003606 ligand binding site [chemical binding]; other site 765952003607 CAAX protease self-immunity; Region: Abi; cl00558 765952003608 Superoxide dismutase [Fe]; Provisional; Region: PTZ00078 765952003609 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 765952003610 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 765952003611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952003612 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 765952003613 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952003614 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 765952003615 GIY-YIG motif/motif A; other site 765952003616 putative active site [active] 765952003617 putative metal binding site [ion binding]; other site 765952003618 RF-1 domain; Region: RF-1; cl02875 765952003619 Flagellin N-methylase; Region: FliB; cl00497 765952003620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765952003621 DNA binding residues [nucleotide binding] 765952003622 dimerization interface [polypeptide binding]; other site 765952003623 Rhomboid family; Region: Rhomboid; cl11446 765952003624 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 765952003625 dimer interface [polypeptide binding]; other site 765952003626 [2Fe-2S] cluster binding site [ion binding]; other site 765952003627 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765952003628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952003629 active site 765952003630 catalytic tetrad [active] 765952003631 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 765952003632 homodimer interaction site [polypeptide binding]; other site 765952003633 cofactor binding site; other site 765952003634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765952003635 catalytic core [active] 765952003636 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 765952003637 nudix motif; other site 765952003638 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 765952003639 nudix motif; other site 765952003640 NmrA-like family; Region: NmrA; pfam05368 765952003641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003642 NAD(P) binding site [chemical binding]; other site 765952003643 active site 765952003644 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765952003645 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952003646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003647 AAA domain; Region: AAA_33; pfam13671 765952003648 P-loop motif; other site 765952003649 ATP binding site [chemical binding]; other site 765952003650 Chloramphenicol (Cm) binding site [chemical binding]; other site 765952003651 catalytic residue [active] 765952003652 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 765952003653 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 765952003654 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 765952003655 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 765952003656 putative active site [active] 765952003657 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 765952003658 CsbD-like; Region: CsbD; cl15799 765952003659 BON domain; Region: BON; cl02771 765952003660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003661 active site 765952003662 ATP binding site [chemical binding]; other site 765952003663 substrate binding site [chemical binding]; other site 765952003664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003665 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 765952003666 GatB domain; Region: GatB_Yqey; cl11497 765952003667 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 765952003668 ABC-2 type transporter; Region: ABC2_membrane; cl11417 765952003669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765952003670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003671 Walker A/P-loop; other site 765952003672 ATP binding site [chemical binding]; other site 765952003673 Q-loop/lid; other site 765952003674 ABC transporter signature motif; other site 765952003675 Walker B; other site 765952003676 D-loop; other site 765952003677 H-loop/switch region; other site 765952003678 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 765952003679 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003680 Walker A/P-loop; other site 765952003681 ATP binding site [chemical binding]; other site 765952003682 Q-loop/lid; other site 765952003683 ABC transporter signature motif; other site 765952003684 Walker B; other site 765952003685 D-loop; other site 765952003686 H-loop/switch region; other site 765952003687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 765952003688 ABC-2 type transporter; Region: ABC2_membrane; cl11417 765952003689 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 765952003690 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952003691 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952003692 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952003693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003694 NADH(P)-binding; Region: NAD_binding_10; pfam13460 765952003695 NAD(P) binding site [chemical binding]; other site 765952003696 active site 765952003697 probable cinnamyl alcohol dehydrogenase; Region: PLN02586 765952003698 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 765952003699 putative NAD(P) binding site [chemical binding]; other site 765952003700 putative substrate binding site [chemical binding]; other site 765952003701 catalytic Zn binding site [ion binding]; other site 765952003702 structural Zn binding site [ion binding]; other site 765952003703 dimer interface [polypeptide binding]; other site 765952003704 Cupin domain; Region: Cupin_2; cl09118 765952003705 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 765952003706 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 765952003707 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765952003708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952003709 active site 765952003710 catalytic tetrad [active] 765952003711 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952003712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003713 S-adenosylmethionine binding site [chemical binding]; other site 765952003714 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 765952003715 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 765952003716 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003717 active site 765952003718 ATP binding site [chemical binding]; other site 765952003719 substrate binding site [chemical binding]; other site 765952003720 dimer interface [polypeptide binding]; other site 765952003721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003722 AAA domain; Region: AAA_18; pfam13238 765952003723 active site 765952003724 Domain of unknown function (DUF3328); Region: DUF3328; pfam11807 765952003725 TMPIT-like protein; Region: TMPIT; pfam07851 765952003726 SpoVG; Region: SpoVG; cl00915 765952003727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 765952003728 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 765952003729 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 765952003730 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 765952003731 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 765952003732 catalytic residues [active] 765952003733 catalytic nucleophile [active] 765952003734 Recombinase; Region: Recombinase; pfam07508 765952003735 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 765952003736 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 765952003737 putative active site [active] 765952003738 catalytic site [active] 765952003739 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 765952003740 PLD-like domain; Region: PLDc_2; pfam13091 765952003741 putative active site [active] 765952003742 catalytic site [active] 765952003743 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 765952003744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003745 Family description; Region: UvrD_C_2; cl15862 765952003746 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 765952003747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952003748 putative substrate translocation pore; other site 765952003749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765952003750 Helix-turn-helix domains; Region: HTH; cl00088 765952003751 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 765952003752 putative effector binding pocket; other site 765952003753 dimerization interface [polypeptide binding]; other site 765952003754 Helix-turn-helix domains; Region: HTH; cl00088 765952003755 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 765952003756 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 765952003757 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952003758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952003759 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765952003760 Walker A/P-loop; other site 765952003761 ATP binding site [chemical binding]; other site 765952003762 Q-loop/lid; other site 765952003763 ABC transporter signature motif; other site 765952003764 Walker B; other site 765952003765 D-loop; other site 765952003766 H-loop/switch region; other site 765952003767 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 765952003768 FtsX-like permease family; Region: FtsX; cl15850 765952003769 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 765952003770 UGMP family protein; Validated; Region: PRK09604 765952003771 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 765952003772 MarC family integral membrane protein; Region: MarC; cl00919 765952003773 MarC family integral membrane protein; Region: MarC; cl00919 765952003774 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 765952003775 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 765952003776 dimerization interface 3.5A [polypeptide binding]; other site 765952003777 active site 765952003778 Domain of unknown function (DUF368); Region: DUF368; cl00893 765952003779 Domain of unknown function (DUF368); Region: DUF368; cl00893 765952003780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 765952003781 ribonuclease HIII; Provisional; Region: PRK00996 765952003782 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 765952003783 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 765952003784 RNA/DNA hybrid binding site [nucleotide binding]; other site 765952003785 active site 765952003786 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 765952003787 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 765952003788 Walker A/P-loop; other site 765952003789 ATP binding site [chemical binding]; other site 765952003790 Q-loop/lid; other site 765952003791 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 765952003792 Q-loop/lid; other site 765952003793 ABC transporter signature motif; other site 765952003794 Walker B; other site 765952003795 D-loop; other site 765952003796 H-loop/switch region; other site 765952003797 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 765952003798 NADP binding site [chemical binding]; other site 765952003799 substrate binding site [chemical binding]; other site 765952003800 active site 765952003801 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765952003802 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952003803 active site 765952003804 catalytic tetrad [active] 765952003805 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765952003806 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 765952003807 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 765952003808 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952003809 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 765952003810 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 765952003811 dimer interface [polypeptide binding]; other site 765952003812 ADP-ribose binding site [chemical binding]; other site 765952003813 active site 765952003814 nudix motif; other site 765952003815 metal binding site [ion binding]; metal-binding site 765952003816 integrase; Provisional; Region: int; PHA02601 765952003817 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003818 active site 765952003819 DNA binding site [nucleotide binding] 765952003820 Int/Topo IB signature motif; other site 765952003821 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 765952003822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952003823 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952003824 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952003825 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952003826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003828 S-adenosylmethionine binding site [chemical binding]; other site 765952003829 TIGR01777 family protein; Region: yfcH 765952003830 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 765952003831 putative NAD(P) binding site [chemical binding]; other site 765952003832 putative active site [active] 765952003833 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 765952003834 putative catalytic residue [active] 765952003835 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952003836 Sel1 repeat; Region: Sel1; cl02723 765952003837 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 765952003838 DNA photolyase; Region: DNA_photolyase; pfam00875 765952003839 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 765952003840 methionine aminopeptidase; Provisional; Region: PRK12318 765952003841 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 765952003842 active site 765952003843 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 765952003844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952003846 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952003847 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 765952003848 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 765952003849 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 765952003850 active site 765952003851 HIGH motif; other site 765952003852 KMSKS motif; other site 765952003853 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 765952003854 tRNA binding surface [nucleotide binding]; other site 765952003855 anticodon binding site; other site 765952003856 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 765952003857 dimer interface [polypeptide binding]; other site 765952003858 putative tRNA-binding site [nucleotide binding]; other site 765952003859 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 765952003860 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 765952003861 catalytic site [active] 765952003862 G-X2-G-X-G-K; other site 765952003863 hypothetical protein; Provisional; Region: PRK11820 765952003864 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 765952003865 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 765952003866 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 765952003867 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 765952003868 dimer interface [polypeptide binding]; other site 765952003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952003870 catalytic residue [active] 765952003871 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 765952003872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 765952003873 homodimer interface [polypeptide binding]; other site 765952003874 substrate-cofactor binding pocket; other site 765952003875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952003876 catalytic residue [active] 765952003877 F-box domain; Region: F-box; cl02535 765952003878 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 765952003879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765952003880 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765952003881 Divalent cation transporter; Region: MgtE; cl00786 765952003882 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 765952003883 RNA/DNA hybrid binding site [nucleotide binding]; other site 765952003884 active site 765952003885 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 765952003886 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 765952003887 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 765952003888 signal recognition particle protein; Provisional; Region: PRK10867 765952003889 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 765952003890 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765952003891 P loop; other site 765952003892 GTP binding site [chemical binding]; other site 765952003893 Signal peptide binding domain; Region: SRP_SPB; pfam02978 765952003894 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 765952003895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003896 S-adenosylmethionine binding site [chemical binding]; other site 765952003897 peptide chain release factor 1; Validated; Region: prfA; PRK00591 765952003898 RF-1 domain; Region: RF-1; cl02875 765952003899 RF-1 domain; Region: RF-1; cl02875 765952003900 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 765952003901 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 765952003902 active site 765952003903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003905 MORN repeat; Region: MORN; cl14787 765952003906 MORN repeat; Region: MORN; cl14787 765952003907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003908 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 765952003909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003910 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765952003911 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 765952003912 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 765952003913 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 765952003914 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 765952003915 active site 765952003916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765952003917 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 765952003918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952003919 catalytic residue [active] 765952003920 glycogen synthase; Provisional; Region: glgA; PRK00654 765952003921 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 765952003922 ADP-binding pocket [chemical binding]; other site 765952003923 homodimer interface [polypeptide binding]; other site 765952003924 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 765952003925 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 765952003926 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 765952003927 substrate binding site [chemical binding]; other site 765952003928 ATP binding site [chemical binding]; other site 765952003929 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952003930 Uncharacterized conserved protein [Function unknown]; Region: COG2042 765952003931 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952003932 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 765952003933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952003934 Family description; Region: UvrD_C_2; cl15862 765952003935 Ribonuclease P; Region: Ribonuclease_P; cl00457 765952003936 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 765952003937 putative active site [active] 765952003938 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 765952003939 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 765952003940 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 765952003941 Asp23 family; Region: Asp23; cl00574 765952003942 BON domain; Region: BON; cl02771 765952003943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003945 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765952003946 active site 765952003947 catalytic site [active] 765952003948 substrate binding site [chemical binding]; other site 765952003949 Maf-like protein; Region: Maf; pfam02545 765952003950 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 765952003951 active site 765952003952 dimer interface [polypeptide binding]; other site 765952003953 HEAT repeats; Region: HEAT_2; pfam13646 765952003954 HEAT repeats; Region: HEAT_2; pfam13646 765952003955 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 765952003956 Organic solvent tolerance protein; Region: OstA_C; pfam04453 765952003957 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952003958 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 765952003959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003960 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 765952003961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003962 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765952003963 substrate binding pocket [chemical binding]; other site 765952003964 chain length determination region; other site 765952003965 substrate-Mg2+ binding site; other site 765952003966 catalytic residues [active] 765952003967 aspartate-rich region 1; other site 765952003968 active site lid residues [active] 765952003969 aspartate-rich region 2; other site 765952003970 Bacterial sugar transferase; Region: Bac_transf; cl00939 765952003971 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 765952003972 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 765952003973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952003974 catalytic residue [active] 765952003975 Domain of unknown function (DUF202); Region: DUF202; cl09954 765952003976 Survival protein SurE; Region: SurE; cl00448 765952003977 Uncharacterized conserved protein [Function unknown]; Region: COG1284 765952003978 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 765952003979 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 765952003980 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 765952003981 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 765952003982 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 765952003983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765952003984 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 765952003985 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 765952003986 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 765952003987 carboxyltransferase (CT) interaction site; other site 765952003988 biotinylation site [posttranslational modification]; other site 765952003989 elongation factor P; Provisional; Region: PRK12426 765952003990 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 765952003991 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 765952003992 RNA binding site [nucleotide binding]; other site 765952003993 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 765952003994 RNA binding site [nucleotide binding]; other site 765952003995 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 765952003996 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 765952003997 substrate binding site [chemical binding]; other site 765952003998 hexamer interface [polypeptide binding]; other site 765952003999 metal binding site [ion binding]; metal-binding site 765952004000 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952004001 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 765952004002 putative catalytic residues [active] 765952004003 putative nucleotide binding site [chemical binding]; other site 765952004004 putative aspartate binding site [chemical binding]; other site 765952004005 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 765952004006 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 765952004007 active site 765952004008 Riboflavin kinase; Region: Flavokinase; cl03312 765952004009 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 765952004010 RNA binding site [nucleotide binding]; other site 765952004011 active site 765952004012 Ribosome-binding factor A; Region: RBFA; cl00542 765952004013 translation initiation factor IF-2; Region: IF-2; TIGR00487 765952004014 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 765952004015 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 765952004016 G1 box; other site 765952004017 putative GEF interaction site [polypeptide binding]; other site 765952004018 GTP/Mg2+ binding site [chemical binding]; other site 765952004019 Switch I region; other site 765952004020 G2 box; other site 765952004021 G3 box; other site 765952004022 Switch II region; other site 765952004023 G4 box; other site 765952004024 G5 box; other site 765952004025 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 765952004026 Translation-initiation factor 2; Region: IF-2; pfam11987 765952004027 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 765952004028 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 765952004029 NusA N-terminal domain; Region: NusA_N; pfam08529 765952004030 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 765952004031 RNA binding site [nucleotide binding]; other site 765952004032 homodimer interface [polypeptide binding]; other site 765952004033 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 765952004034 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 765952004035 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 765952004036 RNA binding site [nucleotide binding]; other site 765952004037 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 765952004038 RNA binding site [nucleotide binding]; other site 765952004039 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952004040 RNA binding site [nucleotide binding]; other site 765952004041 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952004042 RNA binding site [nucleotide binding]; other site 765952004043 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 765952004044 RNA binding site [nucleotide binding]; other site 765952004045 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 765952004046 RNA binding site [nucleotide binding]; other site 765952004047 domain interface; other site 765952004048 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 765952004049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004051 TPR motif; other site 765952004052 binding surface 765952004053 Tetratricopeptide repeat; Region: TPR_9; pfam13371 765952004054 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 765952004055 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 765952004056 inhibitor-cofactor binding pocket; inhibition site 765952004057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952004058 catalytic residue [active] 765952004059 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952004060 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952004061 dimer interface [polypeptide binding]; other site 765952004062 putative CheW interface [polypeptide binding]; other site 765952004063 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 765952004064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765952004065 dimerization interface [polypeptide binding]; other site 765952004066 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952004067 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952004068 dimer interface [polypeptide binding]; other site 765952004069 putative CheW interface [polypeptide binding]; other site 765952004070 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 765952004071 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765952004072 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952004073 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 765952004074 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952004075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952004076 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765952004077 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 765952004078 active site 765952004079 metal binding site [ion binding]; metal-binding site 765952004080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004081 binding surface 765952004082 TPR repeat; Region: TPR_11; pfam13414 765952004083 TPR motif; other site 765952004084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004085 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 765952004086 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 765952004087 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 765952004088 Clp amino terminal domain; Region: Clp_N; pfam02861 765952004089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004090 Walker A motif; other site 765952004091 ATP binding site [chemical binding]; other site 765952004092 Walker B motif; other site 765952004093 arginine finger; other site 765952004094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004095 Walker A motif; other site 765952004096 ATP binding site [chemical binding]; other site 765952004097 Walker B motif; other site 765952004098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 765952004099 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952004100 Response regulator receiver domain; Region: Response_reg; pfam00072 765952004101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952004102 active site 765952004103 phosphorylation site [posttranslational modification] 765952004104 intermolecular recognition site; other site 765952004105 dimerization interface [polypeptide binding]; other site 765952004106 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 765952004107 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952004108 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 765952004109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952004110 active site 765952004111 phosphorylation site [posttranslational modification] 765952004112 intermolecular recognition site; other site 765952004113 CheB methylesterase; Region: CheB_methylest; pfam01339 765952004114 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 765952004115 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 765952004116 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 765952004117 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 765952004118 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 765952004119 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 765952004120 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 765952004121 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 765952004122 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 765952004123 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 765952004124 DNA binding site [nucleotide binding] 765952004125 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 765952004126 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 765952004127 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 765952004128 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 765952004129 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765952004130 RPB11 interaction site [polypeptide binding]; other site 765952004131 RPB12 interaction site [polypeptide binding]; other site 765952004132 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765952004133 RPB3 interaction site [polypeptide binding]; other site 765952004134 RPB1 interaction site [polypeptide binding]; other site 765952004135 RPB11 interaction site [polypeptide binding]; other site 765952004136 RPB10 interaction site [polypeptide binding]; other site 765952004137 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 765952004138 peripheral dimer interface [polypeptide binding]; other site 765952004139 core dimer interface [polypeptide binding]; other site 765952004140 L10 interface [polypeptide binding]; other site 765952004141 L11 interface [polypeptide binding]; other site 765952004142 putative EF-Tu interaction site [polypeptide binding]; other site 765952004143 putative EF-G interaction site [polypeptide binding]; other site 765952004144 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 765952004145 23S rRNA interface [nucleotide binding]; other site 765952004146 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 765952004147 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 765952004148 mRNA/rRNA interface [nucleotide binding]; other site 765952004149 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 765952004150 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 765952004151 23S rRNA interface [nucleotide binding]; other site 765952004152 L7/L12 interface [polypeptide binding]; other site 765952004153 putative thiostrepton binding site; other site 765952004154 L25 interface [polypeptide binding]; other site 765952004155 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 765952004156 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 765952004157 putative homodimer interface [polypeptide binding]; other site 765952004158 KOW motif; Region: KOW; cl00354 765952004159 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 765952004160 elongation factor Tu; Reviewed; Region: PRK12735 765952004161 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 765952004162 G1 box; other site 765952004163 GEF interaction site [polypeptide binding]; other site 765952004164 GTP/Mg2+ binding site [chemical binding]; other site 765952004165 Switch I region; other site 765952004166 G2 box; other site 765952004167 G3 box; other site 765952004168 Switch II region; other site 765952004169 G4 box; other site 765952004170 G5 box; other site 765952004171 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 765952004172 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 765952004173 Antibiotic Binding Site [chemical binding]; other site 765952004174 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 765952004175 rRNA binding site [nucleotide binding]; other site 765952004176 predicted 30S ribosome binding site; other site 765952004177 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 765952004178 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952004179 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 765952004180 putative NAD(P) binding site [chemical binding]; other site 765952004181 putative substrate binding site [chemical binding]; other site 765952004182 catalytic Zn binding site [ion binding]; other site 765952004183 structural Zn binding site [ion binding]; other site 765952004184 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 765952004185 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765952004186 E3 interaction surface; other site 765952004187 lipoyl attachment site [posttranslational modification]; other site 765952004188 e3 binding domain; Region: E3_binding; pfam02817 765952004189 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 765952004190 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 765952004191 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 765952004192 alpha subunit interface [polypeptide binding]; other site 765952004193 TPP binding site [chemical binding]; other site 765952004194 heterodimer interface [polypeptide binding]; other site 765952004195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952004196 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 765952004197 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 765952004198 tetramer interface [polypeptide binding]; other site 765952004199 TPP-binding site [chemical binding]; other site 765952004200 heterodimer interface [polypeptide binding]; other site 765952004201 phosphorylation loop region [posttranslational modification] 765952004202 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765952004203 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 765952004204 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 765952004205 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 765952004206 active site 765952004207 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 765952004208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765952004209 catalytic residue [active] 765952004210 Chitin synthesis regulation, resistance to Congo red; Region: RCR; pfam12273 765952004211 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 765952004212 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 765952004213 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 765952004214 dimer interface [polypeptide binding]; other site 765952004215 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 765952004216 active site residues [active] 765952004217 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 765952004218 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 765952004219 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952004220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004221 binding surface 765952004222 TPR motif; other site 765952004223 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 765952004224 recombination protein F; Reviewed; Region: recF; PRK00064 765952004225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004226 Walker A/P-loop; other site 765952004227 ATP binding site [chemical binding]; other site 765952004228 Q-loop/lid; other site 765952004229 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004230 ABC transporter signature motif; other site 765952004231 Walker B; other site 765952004232 D-loop; other site 765952004233 H-loop/switch region; other site 765952004234 DNA polymerase III subunit beta; Validated; Region: PRK05643 765952004235 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 765952004236 putative DNA binding surface [nucleotide binding]; other site 765952004237 dimer interface [polypeptide binding]; other site 765952004238 beta-clamp/clamp loader binding surface; other site 765952004239 beta-clamp/translesion DNA polymerase binding surface; other site 765952004240 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 765952004241 SmpB-tmRNA interface; other site 765952004242 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 765952004243 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 765952004244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 765952004245 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 765952004246 putative active site [active] 765952004247 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 765952004248 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 765952004249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952004250 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 765952004251 Sodium:solute symporter family; Region: SSF; cl00456 765952004252 UbiA prenyltransferase family; Region: UbiA; cl00337 765952004253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952004254 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 765952004255 substrate binding site [chemical binding]; other site 765952004256 oxyanion hole (OAH) forming residues; other site 765952004257 trimer interface [polypeptide binding]; other site 765952004258 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 765952004259 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 765952004260 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 765952004261 dimer interface [polypeptide binding]; other site 765952004262 tetramer interface [polypeptide binding]; other site 765952004263 PYR/PP interface [polypeptide binding]; other site 765952004264 TPP binding site [chemical binding]; other site 765952004265 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 765952004266 TPP-binding site; other site 765952004267 chorismate binding enzyme; Region: Chorismate_bind; cl10555 765952004268 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 765952004269 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 765952004270 TRAM domain; Region: TRAM; cl01282 765952004271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004272 S-adenosylmethionine binding site [chemical binding]; other site 765952004273 Acetokinase family; Region: Acetate_kinase; cl01029 765952004274 propionate/acetate kinase; Provisional; Region: PRK12379 765952004275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004276 S-adenosylmethionine binding site [chemical binding]; other site 765952004277 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 765952004278 Uncharacterized conserved protein [Function unknown]; Region: COG4285 765952004279 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 765952004280 conserved cys residue [active] 765952004281 TIGR03440 family protein; Region: unchr_TIGR03440 765952004282 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 765952004283 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 765952004284 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 765952004285 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 765952004286 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 765952004287 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 765952004288 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 765952004289 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 765952004290 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 765952004291 RecX family; Region: RecX; cl00936 765952004292 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 765952004293 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 765952004294 CAP-like domain; other site 765952004295 active site 765952004296 primary dimer interface [polypeptide binding]; other site 765952004297 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 765952004298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 765952004299 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 765952004300 anchoring element; other site 765952004301 dimer interface [polypeptide binding]; other site 765952004302 ATP binding site [chemical binding]; other site 765952004303 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 765952004304 active site 765952004305 putative metal-binding site [ion binding]; other site 765952004306 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 765952004307 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 765952004308 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 765952004309 NAD(P) binding site [chemical binding]; other site 765952004310 homodimer interface [polypeptide binding]; other site 765952004311 substrate binding site [chemical binding]; other site 765952004312 active site 765952004313 BNR repeat-like domain; Region: BNR_2; pfam13088 765952004314 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 765952004315 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 765952004316 tRNA; other site 765952004317 putative tRNA binding site [nucleotide binding]; other site 765952004318 putative NADP binding site [chemical binding]; other site 765952004319 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 765952004320 MutS domain I; Region: MutS_I; pfam01624 765952004321 MutS domain II; Region: MutS_II; pfam05188 765952004322 MutS family domain IV; Region: MutS_IV; pfam05190 765952004323 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 765952004324 Walker A/P-loop; other site 765952004325 ATP binding site [chemical binding]; other site 765952004326 Q-loop/lid; other site 765952004327 ABC transporter signature motif; other site 765952004328 Walker B; other site 765952004329 D-loop; other site 765952004330 H-loop/switch region; other site 765952004331 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 765952004332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952004333 active site 765952004334 motif I; other site 765952004335 motif II; other site 765952004336 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952004337 nudix motif; other site 765952004338 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952004339 active site 765952004340 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 765952004341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004342 NAD(P) binding site [chemical binding]; other site 765952004343 active site 765952004344 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 765952004345 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 765952004346 NAD binding site [chemical binding]; other site 765952004347 homotetramer interface [polypeptide binding]; other site 765952004348 homodimer interface [polypeptide binding]; other site 765952004349 substrate binding site [chemical binding]; other site 765952004350 active site 765952004351 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 765952004352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952004353 dimer interface [polypeptide binding]; other site 765952004354 conserved gate region; other site 765952004355 ABC-ATPase subunit interface; other site 765952004356 NMT1/THI5 like; Region: NMT1; pfam09084 765952004357 RHS Repeat; Region: RHS_repeat; cl11982 765952004358 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952004359 RHS Repeat; Region: RHS_repeat; cl11982 765952004360 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952004361 Transposase domain (DUF772); Region: DUF772; cl15789 765952004362 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952004363 RHS Repeat; Region: RHS_repeat; cl11982 765952004364 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952004365 RHS Repeat; Region: RHS_repeat; cl11982 765952004366 RHS Repeat; Region: RHS_repeat; cl11982 765952004367 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 765952004368 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952004369 Protein of unknown function (DUF687); Region: DUF687; pfam05095 765952004370 HEAT repeats; Region: HEAT_2; pfam13646 765952004371 HEAT repeats; Region: HEAT_2; pfam13646 765952004372 HEAT repeats; Region: HEAT_2; pfam13646 765952004373 HEAT repeats; Region: HEAT_2; pfam13646 765952004374 Isochorismatase family; Region: Isochorismatase; pfam00857 765952004375 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 765952004376 catalytic triad [active] 765952004377 dimer interface [polypeptide binding]; other site 765952004378 conserved cis-peptide bond; other site 765952004379 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 765952004380 nucleotide binding site/active site [active] 765952004381 HIT family signature motif; other site 765952004382 catalytic residue [active] 765952004383 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 765952004384 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 765952004385 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 765952004386 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 765952004387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004388 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 765952004389 Walker A/P-loop; other site 765952004390 ATP binding site [chemical binding]; other site 765952004391 Q-loop/lid; other site 765952004392 ABC transporter signature motif; other site 765952004393 Walker B; other site 765952004394 D-loop; other site 765952004395 H-loop/switch region; other site 765952004396 Domain of unknown function DUF87; Region: DUF87; pfam01935 765952004397 AAA-like domain; Region: AAA_10; pfam12846 765952004398 Sodium:solute symporter family; Region: SSF; cl00456 765952004399 tegument protein VP11/12; Provisional; Region: PHA03321 765952004400 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952004401 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952004402 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 765952004403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952004404 Coenzyme A binding pocket [chemical binding]; other site 765952004405 Putative cyclase; Region: Cyclase; cl00814 765952004406 EamA-like transporter family; Region: EamA; cl01037 765952004407 Protein of unknown function (DUF952); Region: DUF952; cl01393 765952004408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952004410 Coenzyme A binding pocket [chemical binding]; other site 765952004411 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952004412 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952004413 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 765952004414 putative NAD(P) binding site [chemical binding]; other site 765952004415 putative substrate binding site [chemical binding]; other site 765952004416 catalytic Zn binding site [ion binding]; other site 765952004417 structural Zn binding site [ion binding]; other site 765952004418 dimer interface [polypeptide binding]; other site 765952004419 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 765952004420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952004421 motif II; other site 765952004422 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952004423 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 765952004424 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952004425 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952004426 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952004427 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952004428 nudix motif; other site 765952004429 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 765952004430 nucleoside/Zn binding site; other site 765952004431 dimer interface [polypeptide binding]; other site 765952004432 catalytic motif [active] 765952004433 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 765952004434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004435 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 765952004436 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 765952004437 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 765952004438 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 765952004439 active site 765952004440 catalytic residue [active] 765952004441 dimer interface [polypeptide binding]; other site 765952004442 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 765952004443 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 765952004444 shikimate binding site; other site 765952004445 NAD(P) binding site [chemical binding]; other site 765952004446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952004447 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 765952004448 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 765952004449 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 765952004450 active site 765952004451 dimer interface [polypeptide binding]; other site 765952004452 metal binding site [ion binding]; metal-binding site 765952004453 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 765952004454 Tetramer interface [polypeptide binding]; other site 765952004455 active site 765952004456 FMN-binding site [chemical binding]; other site 765952004457 shikimate kinase; Reviewed; Region: aroK; PRK00131 765952004458 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 765952004459 ADP binding site [chemical binding]; other site 765952004460 magnesium binding site [ion binding]; other site 765952004461 putative shikimate binding site; other site 765952004462 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 765952004463 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 765952004464 hinge; other site 765952004465 active site 765952004466 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 765952004467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952004468 motif II; other site 765952004469 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 765952004470 Protein required for attachment to host cells; Region: Host_attach; cl02398 765952004471 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 765952004472 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 765952004473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952004474 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 765952004475 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952004476 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 765952004477 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 765952004478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952004479 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 765952004480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952004481 active site 765952004482 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 765952004483 putative dimer interface [polypeptide binding]; other site 765952004484 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 765952004485 FtsX-like permease family; Region: FtsX; cl15850 765952004486 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952004487 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765952004488 Walker A/P-loop; other site 765952004489 ATP binding site [chemical binding]; other site 765952004490 Q-loop/lid; other site 765952004491 ABC transporter signature motif; other site 765952004492 Walker B; other site 765952004493 D-loop; other site 765952004494 H-loop/switch region; other site 765952004495 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 765952004496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952004497 active site 765952004498 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 765952004499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952004500 putative substrate translocation pore; other site 765952004501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952004502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004503 active site 765952004504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004505 NAD(P) binding site [chemical binding]; other site 765952004506 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952004507 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 765952004508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952004509 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004510 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 765952004511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004512 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 765952004513 alpha-glucosidase; Provisional; Region: PRK10137 765952004514 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 765952004515 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 765952004516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004517 NAD(P) binding site [chemical binding]; other site 765952004518 active site 765952004519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952004520 putative substrate translocation pore; other site 765952004521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952004522 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 765952004523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952004524 active site 765952004525 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 765952004526 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 765952004527 Sulfatase; Region: Sulfatase; cl10460 765952004528 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952004529 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 765952004530 dimer interface [polypeptide binding]; other site 765952004531 catalytic triad [active] 765952004532 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952004533 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 765952004534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952004535 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765952004536 active site 765952004537 catalytic tetrad [active] 765952004538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004539 Domain of unknown function (DUF202); Region: DUF202; cl09954 765952004540 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 765952004541 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 765952004542 putative active site [active] 765952004543 putative metal binding site [ion binding]; other site 765952004544 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 765952004545 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952004546 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952004547 active site 765952004548 ATP binding site [chemical binding]; other site 765952004549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952004550 substrate binding site [chemical binding]; other site 765952004551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952004552 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952004553 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 765952004554 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 765952004555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765952004556 non-specific DNA binding site [nucleotide binding]; other site 765952004557 salt bridge; other site 765952004558 sequence-specific DNA binding site [nucleotide binding]; other site 765952004559 D5 N terminal like; Region: D5_N; cl07360 765952004560 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 765952004561 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 765952004562 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 765952004563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952004564 active site 765952004565 DNA binding site [nucleotide binding] 765952004566 Int/Topo IB signature motif; other site 765952004567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 765952004568 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 765952004569 substrate binding pocket [chemical binding]; other site 765952004570 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 765952004571 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 765952004572 active site 765952004573 nucleophile elbow; other site 765952004574 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 765952004575 Lipase maturation factor; Region: LMF1; pfam06762 765952004576 putative phosphoketolase; Provisional; Region: PRK05261 765952004577 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 765952004578 TPP-binding site; other site 765952004579 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 765952004580 XFP C-terminal domain; Region: XFP_C; pfam09363 765952004581 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 765952004582 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952004583 active site 765952004584 ATP binding site [chemical binding]; other site 765952004585 substrate binding site [chemical binding]; other site 765952004586 activation loop (A-loop); other site 765952004587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952004588 binding surface 765952004589 TPR motif; other site 765952004590 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 765952004591 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952004592 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 765952004593 Peptidase family M48; Region: Peptidase_M48; cl12018 765952004594 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765952004595 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765952004596 PPIC-type PPIASE domain; Region: Rotamase; cl08278 765952004597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004598 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 765952004599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952004600 active site 765952004601 catalytic tetrad [active] 765952004602 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 765952004603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 765952004604 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 765952004605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 765952004606 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 765952004607 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 765952004608 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 765952004609 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 765952004610 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 765952004611 generic binding surface II; other site 765952004612 generic binding surface I; other site 765952004613 regulatory protein UhpC; Provisional; Region: PRK11663 765952004614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952004615 putative substrate translocation pore; other site 765952004616 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Region: PLN02925 765952004617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 765952004618 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 765952004619 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 765952004620 active site 765952004621 metal binding site [ion binding]; metal-binding site 765952004622 seryl-tRNA synthetase; Provisional; Region: PRK05431 765952004623 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 765952004624 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 765952004625 dimer interface [polypeptide binding]; other site 765952004626 active site 765952004627 motif 1; other site 765952004628 motif 2; other site 765952004629 motif 3; other site 765952004630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 765952004631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 765952004632 active site 765952004633 3-ketoacyl-CoA thiolase; Provisional; Region: PTZ00455 765952004634 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 765952004635 active site 765952004636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004637 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 765952004638 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 765952004639 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 765952004640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952004641 substrate binding site [chemical binding]; other site 765952004642 oxyanion hole (OAH) forming residues; other site 765952004643 trimer interface [polypeptide binding]; other site 765952004644 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 765952004645 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 765952004646 tetramer interface [polypeptide binding]; other site 765952004647 active site 765952004648 Mg2+/Mn2+ binding site [ion binding]; other site 765952004649 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 765952004650 Citrate synthase; Region: Citrate_synt; pfam00285 765952004651 oxalacetate binding site [chemical binding]; other site 765952004652 citrylCoA binding site [chemical binding]; other site 765952004653 coenzyme A binding site [chemical binding]; other site 765952004654 catalytic triad [active] 765952004655 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 765952004656 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 765952004657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952004658 active site 765952004659 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 765952004660 nucleophilic elbow; other site 765952004661 catalytic triad; other site 765952004662 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 765952004663 FMN-binding domain; Region: FMN_bind; cl01081 765952004664 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 765952004665 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 765952004666 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 765952004667 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 765952004668 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 765952004669 homodimer interface [polypeptide binding]; other site 765952004670 active site pocket [active] 765952004671 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 765952004672 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952004673 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952004674 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 765952004675 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 765952004676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952004677 dimer interface [polypeptide binding]; other site 765952004678 conserved gate region; other site 765952004679 putative PBP binding loops; other site 765952004680 ABC-ATPase subunit interface; other site 765952004681 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 765952004682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952004683 dimer interface [polypeptide binding]; other site 765952004684 conserved gate region; other site 765952004685 ABC-ATPase subunit interface; other site 765952004686 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 765952004687 DnaA N-terminal domain; Region: DnaA_N; pfam11638 765952004688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004689 Walker A motif; other site 765952004690 ATP binding site [chemical binding]; other site 765952004691 Walker B motif; other site 765952004692 arginine finger; other site 765952004693 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 765952004694 DnaA box-binding interface [nucleotide binding]; other site 765952004695 ferrochelatase; Reviewed; Region: hemH; PRK00035 765952004696 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 765952004697 C-terminal domain interface [polypeptide binding]; other site 765952004698 active site 765952004699 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 765952004700 active site 765952004701 N-terminal domain interface [polypeptide binding]; other site 765952004702 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952004703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952004704 substrate binding pocket [chemical binding]; other site 765952004705 membrane-bound complex binding site; other site 765952004706 hinge residues; other site 765952004707 cytidylate kinase; Provisional; Region: cmk; PRK00023 765952004708 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 765952004709 CMP-binding site; other site 765952004710 The sites determining sugar specificity; other site 765952004711 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 765952004712 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 765952004713 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 765952004714 catalytic residue [active] 765952004715 putative FPP diphosphate binding site; other site 765952004716 putative FPP binding hydrophobic cleft; other site 765952004717 dimer interface [polypeptide binding]; other site 765952004718 putative IPP diphosphate binding site; other site 765952004719 GTP-binding protein LepA; Provisional; Region: PRK05433 765952004720 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 765952004721 G1 box; other site 765952004722 putative GEF interaction site [polypeptide binding]; other site 765952004723 GTP/Mg2+ binding site [chemical binding]; other site 765952004724 Switch I region; other site 765952004725 G2 box; other site 765952004726 G3 box; other site 765952004727 Switch II region; other site 765952004728 G4 box; other site 765952004729 G5 box; other site 765952004730 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 765952004731 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 765952004732 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 765952004733 Thiamine pyrophosphokinase; Region: TPK; cd07995 765952004734 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 765952004735 active site 765952004736 dimerization interface [polypeptide binding]; other site 765952004737 thiamine binding site [chemical binding]; other site 765952004738 Ferritin-like domain; Region: Ferritin; pfam00210 765952004739 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 765952004740 dimerization interface [polypeptide binding]; other site 765952004741 DPS ferroxidase diiron center [ion binding]; other site 765952004742 ion pore; other site 765952004743 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 765952004744 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 765952004745 putative NAD(P) binding site [chemical binding]; other site 765952004746 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952004747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952004748 dimer interface [polypeptide binding]; other site 765952004749 putative CheW interface [polypeptide binding]; other site 765952004750 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 765952004751 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 765952004752 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 765952004753 alphaNTD homodimer interface [polypeptide binding]; other site 765952004754 alphaNTD - beta interaction site [polypeptide binding]; other site 765952004755 alphaNTD - beta' interaction site [polypeptide binding]; other site 765952004756 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 765952004757 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 765952004758 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 765952004759 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 765952004760 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 765952004761 SecY translocase; Region: SecY; pfam00344 765952004762 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 765952004763 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 765952004764 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 765952004765 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 765952004766 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 765952004767 5S rRNA interface [nucleotide binding]; other site 765952004768 23S rRNA interface [nucleotide binding]; other site 765952004769 L5 interface [polypeptide binding]; other site 765952004770 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 765952004771 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765952004772 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765952004773 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 765952004774 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 765952004775 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 765952004776 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 765952004777 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 765952004778 KOW motif; Region: KOW; cl00354 765952004779 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 765952004780 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 765952004781 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 765952004782 23S rRNA interface [nucleotide binding]; other site 765952004783 putative translocon interaction site; other site 765952004784 signal recognition particle (SRP54) interaction site; other site 765952004785 L23 interface [polypeptide binding]; other site 765952004786 trigger factor interaction site; other site 765952004787 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 765952004788 23S rRNA interface [nucleotide binding]; other site 765952004789 5S rRNA interface [nucleotide binding]; other site 765952004790 putative antibiotic binding site [chemical binding]; other site 765952004791 L25 interface [polypeptide binding]; other site 765952004792 L27 interface [polypeptide binding]; other site 765952004793 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 765952004794 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 765952004795 G-X-X-G motif; other site 765952004796 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 765952004797 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 765952004798 putative translocon binding site; other site 765952004799 protein-rRNA interface [nucleotide binding]; other site 765952004800 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 765952004801 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 765952004802 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 765952004803 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 765952004804 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 765952004805 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 765952004806 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 765952004807 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 765952004808 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 765952004809 putative active site [active] 765952004810 substrate binding site [chemical binding]; other site 765952004811 putative cosubstrate binding site; other site 765952004812 catalytic site [active] 765952004813 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 765952004814 substrate binding site [chemical binding]; other site 765952004815 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 765952004816 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 765952004817 active site 765952004818 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 765952004819 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 765952004820 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 765952004821 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 765952004822 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 765952004823 putative active site [active] 765952004824 catalytic triad [active] 765952004825 putative dimer interface [polypeptide binding]; other site 765952004826 DoxX; Region: DoxX; cl00976 765952004827 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 765952004828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 765952004829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952004830 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 765952004831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952004832 active site 765952004833 HIGH motif; other site 765952004834 nucleotide binding site [chemical binding]; other site 765952004835 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 765952004836 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 765952004837 active site 765952004838 KMSKS motif; other site 765952004839 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 765952004840 tRNA binding surface [nucleotide binding]; other site 765952004841 anticodon binding site; other site 765952004842 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 765952004843 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952004844 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952004845 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952004846 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952004847 NeuB family; Region: NeuB; cl00496 765952004848 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 765952004849 V-type ATP synthase subunit K; Provisional; Region: PRK09621 765952004850 ATP synthase subunit C; Region: ATP-synt_C; cl00466 765952004851 V-type ATP synthase subunit I; Validated; Region: PRK05771 765952004852 ATP synthase subunit D; Region: ATP-synt_D; cl00613 765952004853 V-type ATP synthase subunit B; Provisional; Region: PRK02118 765952004854 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 765952004855 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 765952004856 Walker A motif homologous position; other site 765952004857 Walker B motif; other site 765952004858 V-type ATP synthase subunit A; Provisional; Region: PRK04192 765952004859 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 765952004860 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 765952004861 Walker A motif/ATP binding site; other site 765952004862 Walker B motif; other site 765952004863 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765952004864 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 765952004865 Plant ATP synthase F0; Region: YMF19; cl07975 765952004866 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952004867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004868 NAD(P) binding site [chemical binding]; other site 765952004869 active site 765952004870 Vitamin K epoxide reductase family; Region: VKOR; cl01729 765952004871 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952004872 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952004873 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952004874 MULE transposase domain; Region: MULE; pfam10551 765952004875 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952004876 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952004877 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952004878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952004879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 765952004880 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 765952004881 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 765952004882 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 765952004883 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 765952004884 alpha subunit interaction interface [polypeptide binding]; other site 765952004885 Walker A motif; other site 765952004886 ATP binding site [chemical binding]; other site 765952004887 Walker B motif; other site 765952004888 inhibitor binding site; inhibition site 765952004889 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765952004890 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 765952004891 ATP synthase; Region: ATP-synt; cl00365 765952004892 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 765952004893 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 765952004894 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 765952004895 beta subunit interaction interface [polypeptide binding]; other site 765952004896 Walker A motif; other site 765952004897 ATP binding site [chemical binding]; other site 765952004898 Walker B motif; other site 765952004899 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765952004900 Plant ATP synthase F0; Region: YMF19; cl07975 765952004901 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 765952004902 Plant ATP synthase F0; Region: YMF19; cl07975 765952004903 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 765952004904 ATP synthase subunit C; Region: ATP-synt_C; cl00466 765952004905 ATP synthase A chain; Region: ATP-synt_A; cl00413 765952004906 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 765952004907 transaldolase-like protein; Provisional; Region: PTZ00411 765952004908 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 765952004909 active site 765952004910 dimer interface [polypeptide binding]; other site 765952004911 catalytic residue [active] 765952004912 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 765952004913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004914 Walker A motif; other site 765952004915 ATP binding site [chemical binding]; other site 765952004916 Walker B motif; other site 765952004917 arginine finger; other site 765952004918 Peptidase family M41; Region: Peptidase_M41; pfam01434 765952004919 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 765952004920 Ligand Binding Site [chemical binding]; other site 765952004921 B3/4 domain; Region: B3_4; cl11458 765952004922 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 765952004923 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 765952004924 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 765952004925 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 765952004926 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 765952004927 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 765952004928 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952004929 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952004930 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 765952004931 active site 765952004932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765952004933 dimer interface [polypeptide binding]; other site 765952004934 substrate binding site [chemical binding]; other site 765952004935 catalytic residues [active] 765952004936 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 765952004937 RloB-like protein; Region: RloB; pfam13707 765952004938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004939 AAA domain; Region: AAA_21; pfam13304 765952004940 Walker A/P-loop; other site 765952004941 ATP binding site [chemical binding]; other site 765952004942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004943 Walker B; other site 765952004944 D-loop; other site 765952004945 H-loop/switch region; other site 765952004946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004947 NAD(P) binding site [chemical binding]; other site 765952004948 active site 765952004949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004950 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 765952004951 nudix motif; other site 765952004952 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 765952004953 PhnA protein; Region: PhnA; pfam03831 765952004954 short chain dehydrogenase; Provisional; Region: PRK06180 765952004955 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 765952004956 NADP binding site [chemical binding]; other site 765952004957 active site 765952004958 steroid binding site; other site 765952004959 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 765952004960 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 765952004961 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 765952004962 putative NAD(P) binding site [chemical binding]; other site 765952004963 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 765952004964 Nitronate monooxygenase; Region: NMO; pfam03060 765952004965 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 765952004966 phosphate binding site [ion binding]; other site 765952004967 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 765952004968 FMN binding site [chemical binding]; other site 765952004969 substrate binding site [chemical binding]; other site 765952004970 putative catalytic residue [active] 765952004971 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952004972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004973 NAD(P) binding site [chemical binding]; other site 765952004974 active site 765952004975 Pirin-related protein [General function prediction only]; Region: COG1741 765952004976 Cupin domain; Region: Cupin_2; cl09118 765952004977 Cupin domain; Region: Cupin_2; cl09118 765952004978 Cupin domain; Region: Cupin_2; cl09118 765952004979 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 765952004980 classical (c) SDRs; Region: SDR_c; cd05233 765952004981 NAD(P) binding site [chemical binding]; other site 765952004982 active site 765952004983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004984 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 765952004985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952004987 ATP binding site [chemical binding]; other site 765952004988 Walker B motif; other site 765952004989 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 765952004990 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 765952004991 classical (c) SDRs; Region: SDR_c; cd05233 765952004992 NAD(P) binding site [chemical binding]; other site 765952004993 active site 765952004994 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765952004995 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 765952004996 ABC transporter; Region: ABC_tran_2; pfam12848 765952004997 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 765952004998 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 765952004999 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 765952005000 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 765952005001 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 765952005002 classical (c) SDRs; Region: SDR_c; cd05233 765952005003 NAD(P) binding site [chemical binding]; other site 765952005004 active site 765952005005 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 765952005006 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 765952005007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765952005008 Zn2+ binding site [ion binding]; other site 765952005009 Mg2+ binding site [ion binding]; other site 765952005010 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 765952005011 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 765952005012 NAD binding site [chemical binding]; other site 765952005013 homodimer interface [polypeptide binding]; other site 765952005014 active site 765952005015 substrate binding site [chemical binding]; other site 765952005016 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952005017 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 765952005018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952005019 Walker A motif; other site 765952005020 ATP binding site [chemical binding]; other site 765952005021 Walker B motif; other site 765952005022 arginine finger; other site 765952005023 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 765952005024 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 765952005025 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 765952005026 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 765952005027 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 765952005028 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 765952005029 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 765952005030 dimerization domain swap beta strand [polypeptide binding]; other site 765952005031 regulatory protein interface [polypeptide binding]; other site 765952005032 active site 765952005033 regulatory phosphorylation site [posttranslational modification]; other site 765952005034 HPr kinase/phosphorylase; Provisional; Region: PRK05428 765952005035 DRTGG domain; Region: DRTGG; cl12147 765952005036 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 765952005037 Hpr binding site; other site 765952005038 active site 765952005039 homohexamer subunit interaction site [polypeptide binding]; other site 765952005040 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 765952005041 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 765952005042 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 765952005043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952005044 active site 765952005045 phosphorylation site [posttranslational modification] 765952005046 intermolecular recognition site; other site 765952005047 dimerization interface [polypeptide binding]; other site 765952005048 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 765952005049 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952005050 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 765952005051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 765952005052 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 765952005053 anti sigma factor interaction site; other site 765952005054 regulatory phosphorylation site [posttranslational modification]; other site 765952005055 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 765952005056 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 765952005057 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 765952005058 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 765952005059 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 765952005060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005061 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 765952005062 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 765952005063 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 765952005064 active site 765952005065 metal-binding site 765952005066 Predicted acyl esterases [General function prediction only]; Region: COG2936 765952005067 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 765952005068 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 765952005069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952005070 motif II; other site 765952005071 regulatory protein UhpC; Provisional; Region: PRK11663 765952005072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005073 putative substrate translocation pore; other site 765952005074 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 765952005075 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 765952005076 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765952005077 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 765952005078 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952005079 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765952005080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952005081 Walker A/P-loop; other site 765952005082 ATP binding site [chemical binding]; other site 765952005083 Q-loop/lid; other site 765952005084 ABC transporter signature motif; other site 765952005085 Walker B; other site 765952005086 D-loop; other site 765952005087 H-loop/switch region; other site 765952005088 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765952005089 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 765952005090 FtsX-like permease family; Region: FtsX; cl15850 765952005091 Competence protein CoiA-like family; Region: CoiA; cl11541 765952005092 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 765952005093 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 765952005094 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 765952005095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765952005096 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 765952005097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765952005098 DNA binding residues [nucleotide binding] 765952005099 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 765952005100 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005102 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 765952005103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005104 Bacitracin resistance protein BacA; Region: BacA; cl00858 765952005105 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 765952005106 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 765952005107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005108 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 765952005109 AAA domain; Region: AAA_32; pfam13654 765952005110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952005111 chaperone protein DnaJ; Provisional; Region: PRK14284 765952005112 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765952005113 HSP70 interaction site [polypeptide binding]; other site 765952005114 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 765952005115 Zn binding sites [ion binding]; other site 765952005116 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 765952005117 dimer interface [polypeptide binding]; other site 765952005118 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 765952005119 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 765952005120 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 765952005121 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 765952005122 RNA binding site [nucleotide binding]; other site 765952005123 homodimer interface [polypeptide binding]; other site 765952005124 GTPase RsgA; Reviewed; Region: PRK00098 765952005125 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 765952005126 GTPase/Zn-binding domain interface [polypeptide binding]; other site 765952005127 GTP/Mg2+ binding site [chemical binding]; other site 765952005128 G4 box; other site 765952005129 G5 box; other site 765952005130 G1 box; other site 765952005131 Switch I region; other site 765952005132 G2 box; other site 765952005133 G3 box; other site 765952005134 Switch II region; other site 765952005135 enolase; Provisional; Region: eno; PRK00077 765952005136 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 765952005137 dimer interface [polypeptide binding]; other site 765952005138 metal binding site [ion binding]; metal-binding site 765952005139 substrate binding pocket [chemical binding]; other site 765952005140 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 765952005141 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 765952005142 active site 765952005143 catalytic site [active] 765952005144 lipoprotein signal peptidase; Provisional; Region: PRK14787 765952005145 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 765952005146 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 765952005147 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 765952005148 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 765952005149 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 765952005150 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 765952005151 Phosphoglycerate kinase; Region: PGK; pfam00162 765952005152 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 765952005153 substrate binding site [chemical binding]; other site 765952005154 hinge regions; other site 765952005155 ADP binding site [chemical binding]; other site 765952005156 catalytic site [active] 765952005157 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952005158 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 765952005159 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952005160 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 765952005161 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 765952005162 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 765952005163 Dimer interface [polypeptide binding]; other site 765952005164 anticodon binding site; other site 765952005165 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 765952005166 motif 1; other site 765952005167 dimer interface [polypeptide binding]; other site 765952005168 active site 765952005169 motif 2; other site 765952005170 motif 3; other site 765952005171 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 765952005172 putative deacylase active site [active] 765952005173 thiamine monophosphate kinase; Provisional; Region: PRK05731 765952005174 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 765952005175 ATP binding site [chemical binding]; other site 765952005176 dimerization interface [polypeptide binding]; other site 765952005177 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 765952005178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005179 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 765952005180 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 765952005181 transmembrane helices; other site 765952005182 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 765952005183 active site 765952005184 putative substrate binding region [chemical binding]; other site 765952005185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952005186 binding surface 765952005187 TPR motif; other site 765952005188 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 765952005189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005190 CoA-ligase; Region: Ligase_CoA; cl02894 765952005191 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 765952005192 ATP-grasp domain; Region: ATP-grasp_4; cl03087 765952005193 CoA-ligase; Region: Ligase_CoA; cl02894 765952005194 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 765952005195 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 765952005196 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765952005197 P loop; other site 765952005198 GTP binding site [chemical binding]; other site 765952005199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005201 active site 765952005202 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005203 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005205 MULE transposase domain; Region: MULE; pfam10551 765952005206 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 765952005207 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 765952005208 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 765952005209 short chain dehydrogenase; Provisional; Region: PRK08278 765952005210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005211 NAD(P) binding site [chemical binding]; other site 765952005212 active site 765952005213 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 765952005214 Tir chaperone protein (CesT) family; Region: CesT; cl08444 765952005215 Uncharacterized conserved protein [Function unknown]; Region: COG1262 765952005216 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 765952005217 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952005218 active site 765952005219 metal binding site [ion binding]; metal-binding site 765952005220 heat shock protein 90; Provisional; Region: PRK05218 765952005221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952005222 ATP binding site [chemical binding]; other site 765952005223 Mg2+ binding site [ion binding]; other site 765952005224 G-X-G motif; other site 765952005225 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 765952005226 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765952005227 putative metal binding residues [ion binding]; other site 765952005228 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 765952005229 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 765952005230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952005231 ABC-ATPase subunit interface; other site 765952005232 dimer interface [polypeptide binding]; other site 765952005233 putative PBP binding regions; other site 765952005234 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 765952005235 putative active site pocket [active] 765952005236 dimerization interface [polypeptide binding]; other site 765952005237 putative catalytic residue [active] 765952005238 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005239 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005240 MULE transposase domain; Region: MULE; pfam10551 765952005241 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952005242 nudix motif; other site 765952005243 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 765952005244 active site 765952005245 FMN binding site [chemical binding]; other site 765952005246 substrate binding site [chemical binding]; other site 765952005247 homotetramer interface [polypeptide binding]; other site 765952005248 catalytic residue [active] 765952005249 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 765952005250 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 765952005251 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952005252 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765952005253 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 765952005254 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 765952005255 Divergent AAA domain; Region: AAA_4; pfam04326 765952005256 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 765952005257 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 765952005258 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 765952005259 dimer interface [polypeptide binding]; other site 765952005260 motif 1; other site 765952005261 active site 765952005262 motif 2; other site 765952005263 motif 3; other site 765952005264 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 765952005265 anticodon binding site; other site 765952005266 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 765952005267 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 765952005268 dimer interface [polypeptide binding]; other site 765952005269 anticodon binding site; other site 765952005270 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 765952005271 homodimer interface [polypeptide binding]; other site 765952005272 motif 1; other site 765952005273 active site 765952005274 motif 2; other site 765952005275 GAD domain; Region: GAD; pfam02938 765952005276 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 765952005277 active site 765952005278 motif 3; other site 765952005279 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 765952005280 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 765952005281 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765952005282 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 765952005283 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765952005284 catalytic residues [active] 765952005285 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 765952005286 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 765952005287 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 765952005288 active site residue [active] 765952005289 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 765952005290 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 765952005291 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 765952005292 Histone H1-like protein Hc1; Region: Hc1; pfam07432 765952005293 SET domain; Region: SET; cl02566 765952005294 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 765952005295 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765952005296 minor groove reading motif; other site 765952005297 helix-hairpin-helix signature motif; other site 765952005298 substrate binding pocket [chemical binding]; other site 765952005299 active site 765952005300 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 765952005301 DNA binding and oxoG recognition site [nucleotide binding] 765952005302 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 765952005303 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765952005304 putative active site [active] 765952005305 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952005306 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 765952005307 active site 765952005308 putative DNA-binding cleft [nucleotide binding]; other site 765952005309 dimer interface [polypeptide binding]; other site 765952005310 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 765952005311 RuvA N terminal domain; Region: RuvA_N; pfam01330 765952005312 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 765952005313 Preprotein translocase subunit; Region: YajC; cl00806 765952005314 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 765952005315 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 765952005316 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 765952005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 765952005318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952005319 S-adenosylmethionine binding site [chemical binding]; other site 765952005320 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 765952005321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005322 active site 765952005323 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952005324 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 765952005325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005326 active site 765952005327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952005328 binding surface 765952005329 TPR motif; other site 765952005330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005331 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952005332 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 765952005333 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 765952005334 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 765952005335 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 765952005336 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 765952005337 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 765952005338 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 765952005339 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 765952005340 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 765952005341 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 765952005342 Walker A motif; other site 765952005343 ATP binding site [chemical binding]; other site 765952005344 Walker B motif; other site 765952005345 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 765952005346 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 765952005347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005348 putative substrate translocation pore; other site 765952005349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005353 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 765952005354 homotrimer interaction site [polypeptide binding]; other site 765952005355 putative active site [active] 765952005356 replicative DNA helicase; Provisional; Region: PRK06321 765952005357 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 765952005358 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 765952005359 Walker A motif; other site 765952005360 ATP binding site [chemical binding]; other site 765952005361 Walker B motif; other site 765952005362 DNA binding loops [nucleotide binding] 765952005363 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952005364 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 765952005365 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 765952005366 glutaminase active site [active] 765952005367 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 765952005368 dimer interface [polypeptide binding]; other site 765952005369 active site 765952005370 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 765952005371 dimer interface [polypeptide binding]; other site 765952005372 active site 765952005373 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 765952005374 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 765952005375 active site 765952005376 substrate binding site [chemical binding]; other site 765952005377 metal binding site [ion binding]; metal-binding site 765952005378 F-box domain; Region: F-box; cl02535 765952005379 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952005380 structural tetrad; other site 765952005381 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 765952005382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765952005383 minor groove reading motif; other site 765952005384 helix-hairpin-helix signature motif; other site 765952005385 substrate binding pocket [chemical binding]; other site 765952005386 active site 765952005387 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 765952005388 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 765952005389 trmE is a tRNA modification GTPase; Region: trmE; cd04164 765952005390 G1 box; other site 765952005391 GTP/Mg2+ binding site [chemical binding]; other site 765952005392 Switch I region; other site 765952005393 G2 box; other site 765952005394 Switch II region; other site 765952005395 G3 box; other site 765952005396 G4 box; other site 765952005397 G5 box; other site 765952005398 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 765952005399 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 765952005400 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 765952005401 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 765952005402 putative active site; other site 765952005403 catalytic residue [active] 765952005404 MoxR-like ATPases [General function prediction only]; Region: COG0714 765952005405 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005406 Peptidase family M48; Region: Peptidase_M48; cl12018 765952005407 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 765952005408 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 765952005409 metal binding site [ion binding]; metal-binding site 765952005410 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 765952005411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952005412 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952005413 lipoyl synthase; Provisional; Region: PRK05481 765952005414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952005415 FeS/SAM binding site; other site 765952005416 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 765952005417 arginine-tRNA ligase; Region: PLN02286 765952005418 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 765952005419 active site 765952005420 HIGH motif; other site 765952005421 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 765952005422 KMSK motif region; other site 765952005423 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765952005424 tRNA binding surface [nucleotide binding]; other site 765952005425 anticodon binding site; other site 765952005426 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 765952005427 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 765952005428 tetramer interface [polypeptide binding]; other site 765952005429 heme binding pocket [chemical binding]; other site 765952005430 NADPH binding site [chemical binding]; other site 765952005431 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 765952005432 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952005433 Protein of unknown function (DUF3638); Region: DUF3638; pfam12340 765952005434 Protein of unknown function (DUF342); Region: DUF342; pfam03961 765952005435 prolyl-tRNA synthetase; Provisional; Region: PRK08661 765952005436 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 765952005437 dimer interface [polypeptide binding]; other site 765952005438 motif 1; other site 765952005439 active site 765952005440 motif 2; other site 765952005441 motif 3; other site 765952005442 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 765952005443 anticodon binding site; other site 765952005444 zinc-binding site [ion binding]; other site 765952005445 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 765952005446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005447 putative substrate translocation pore; other site 765952005448 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 765952005449 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952005450 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952005451 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 765952005452 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 765952005453 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 765952005454 Ligand Binding Site [chemical binding]; other site 765952005455 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 765952005456 GAF domain; Region: GAF; cl15785 765952005457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 765952005458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952005459 ATP binding site [chemical binding]; other site 765952005460 Mg2+ binding site [ion binding]; other site 765952005461 G-X-G motif; other site 765952005462 K+-transporting ATPase, c chain; Region: KdpC; cl00944 765952005463 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 765952005464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952005465 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 765952005466 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005467 RHS Repeat; Region: RHS_repeat; cl11982 765952005468 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005469 RHS Repeat; Region: RHS_repeat; cl11982 765952005470 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952005472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 765952005473 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 765952005474 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 765952005475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005476 active site 765952005477 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 765952005478 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005479 extended (e) SDRs; Region: SDR_e; cd08946 765952005480 NAD(P) binding site [chemical binding]; other site 765952005481 active site 765952005482 substrate binding site [chemical binding]; other site 765952005483 Cupin domain; Region: Cupin_2; cl09118 765952005484 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 765952005485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005486 NAD(P) binding site [chemical binding]; other site 765952005487 active site 765952005488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005489 active site 765952005490 Sodium:solute symporter family; Region: SSF; cl00456 765952005491 Uncharacterized conserved protein [Function unknown]; Region: COG3535 765952005492 Protein of unknown function (DUF917); Region: DUF917; pfam06032 765952005493 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 765952005494 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 765952005495 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 765952005496 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 765952005497 motif 1; other site 765952005498 dimer interface [polypeptide binding]; other site 765952005499 active site 765952005500 motif 2; other site 765952005501 motif 3; other site 765952005502 translation elongation factor P; Region: efp; TIGR00038 765952005503 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 765952005504 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 765952005505 RNA binding site [nucleotide binding]; other site 765952005506 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 765952005507 RNA binding site [nucleotide binding]; other site 765952005508 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 765952005509 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 765952005510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952005511 TPR motif; other site 765952005512 binding surface 765952005513 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765952005514 nucleotide binding site/active site [active] 765952005515 HIT family signature motif; other site 765952005516 catalytic residue [active] 765952005517 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 765952005518 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 765952005519 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 765952005520 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 765952005521 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 765952005522 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 765952005523 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 765952005524 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 765952005525 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 765952005526 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 765952005527 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 765952005528 4Fe-4S binding domain; Region: Fer4; cl02805 765952005529 4Fe-4S binding domain; Region: Fer4; cl02805 765952005530 NADH dehydrogenase; Region: NADHdh; cl00469 765952005531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765952005532 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 765952005533 catalytic loop [active] 765952005534 iron binding site [ion binding]; other site 765952005535 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 765952005536 MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768 765952005537 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 765952005538 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 765952005539 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 765952005540 SLBB domain; Region: SLBB; pfam10531 765952005541 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 765952005542 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 765952005543 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 765952005544 putative dimer interface [polypeptide binding]; other site 765952005545 [2Fe-2S] cluster binding site [ion binding]; other site 765952005546 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 765952005547 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 765952005548 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 765952005549 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 765952005550 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 765952005551 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 765952005552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005553 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 765952005554 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 765952005555 Low-spin heme binding site [chemical binding]; other site 765952005556 D-pathway; other site 765952005557 Putative water exit pathway; other site 765952005558 Binuclear center (active site) [active] 765952005559 K-pathway; other site 765952005560 Putative proton exit pathway; other site 765952005561 Cytochrome c; Region: Cytochrom_C; cl11414 765952005562 Cytochrome c; Region: Cytochrom_C; cl11414 765952005563 Cytochrome c; Region: Cytochrom_C; cl11414 765952005564 phosphodiesterase; Provisional; Region: PRK12704 765952005565 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 765952005566 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 765952005567 interchain domain interface [polypeptide binding]; other site 765952005568 heme bL binding site [chemical binding]; other site 765952005569 intrachain domain interface; other site 765952005570 heme bH binding site [chemical binding]; other site 765952005571 Qo binding site; other site 765952005572 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 765952005573 iron-sulfur cluster [ion binding]; other site 765952005574 [2Fe-2S] cluster binding site [ion binding]; other site 765952005575 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 765952005576 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 765952005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952005579 4Fe-4S binding domain; Region: Fer4; cl02805 765952005580 4Fe-4S binding domain; Region: Fer4; cl02805 765952005581 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765952005582 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 765952005583 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 765952005584 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 765952005585 dimer interface [polypeptide binding]; other site 765952005586 active site 765952005587 Proline dehydrogenase; Region: Pro_dh; cl03282 765952005588 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 765952005589 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765952005590 Glutamate binding site [chemical binding]; other site 765952005591 NAD binding site [chemical binding]; other site 765952005592 catalytic residues [active] 765952005593 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 765952005594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005595 Family description; Region: UvrD_C_2; cl15862 765952005596 Transposase domain (DUF772); Region: DUF772; cl15789 765952005597 Transposase domain (DUF772); Region: DUF772; cl15789 765952005598 Integrase core domain; Region: rve_3; cl15866 765952005599 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 765952005600 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 765952005601 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 765952005602 active site 765952005603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 765952005604 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765952005605 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 765952005606 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 765952005607 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 765952005608 pseudouridine synthase; Region: TIGR00093 765952005609 active site 765952005610 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 765952005611 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 765952005612 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 765952005613 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 765952005614 dimer interface [polypeptide binding]; other site 765952005615 allosteric magnesium binding site [ion binding]; other site 765952005616 active site 765952005617 aspartate-rich active site metal binding site; other site 765952005618 Schiff base residues; other site 765952005619 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 765952005620 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 765952005621 catalytic triad [active] 765952005622 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 765952005623 putative metal binding site; other site 765952005624 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005625 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005626 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 765952005627 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 765952005628 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765952005629 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 765952005630 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 765952005631 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 765952005632 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765952005633 protein binding site [polypeptide binding]; other site 765952005634 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765952005635 protein binding site [polypeptide binding]; other site 765952005636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952005637 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952005638 substrate binding pocket [chemical binding]; other site 765952005639 membrane-bound complex binding site; other site 765952005640 hinge residues; other site 765952005641 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 765952005642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952005643 dimer interface [polypeptide binding]; other site 765952005644 conserved gate region; other site 765952005645 putative PBP binding loops; other site 765952005646 ABC-ATPase subunit interface; other site 765952005647 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765952005648 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005649 Walker A/P-loop; other site 765952005650 ATP binding site [chemical binding]; other site 765952005651 Q-loop/lid; other site 765952005652 ABC transporter signature motif; other site 765952005653 Walker B; other site 765952005654 D-loop; other site 765952005655 H-loop/switch region; other site 765952005656 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 765952005657 MatE; Region: MatE; cl10513 765952005658 MatE; Region: MatE; cl10513 765952005659 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 765952005660 DevC protein; Region: devC; TIGR01185 765952005661 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765952005662 FtsX-like permease family; Region: FtsX; cl15850 765952005663 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952005664 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 765952005665 Walker A/P-loop; other site 765952005666 ATP binding site [chemical binding]; other site 765952005667 Q-loop/lid; other site 765952005668 ABC transporter signature motif; other site 765952005669 Walker B; other site 765952005670 D-loop; other site 765952005671 H-loop/switch region; other site 765952005672 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 765952005673 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952005674 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 765952005675 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952005676 PLD-like domain; Region: PLDc_2; pfam13091 765952005677 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 765952005678 putative active site [active] 765952005679 catalytic site [active] 765952005680 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 765952005681 putative active site [active] 765952005682 catalytic site [active] 765952005683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 765952005684 YheO-like PAS domain; Region: PAS_6; pfam08348 765952005685 Helix-turn-helix domains; Region: HTH; cl00088 765952005686 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 765952005687 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 765952005688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 765952005689 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 765952005690 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 765952005691 active site 765952005692 dimer interface [polypeptide binding]; other site 765952005693 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 765952005694 Ligand Binding Site [chemical binding]; other site 765952005695 Molecular Tunnel; other site 765952005696 Bordetella bronchiseptica enzymes WbmH and WbmG-like, extended (e) SDRs; Region: WbmH_like_SDR_e; cd08957 765952005697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005698 NAD binding site [chemical binding]; other site 765952005699 homodimer interface [polypeptide binding]; other site 765952005700 active site 765952005701 putative substrate binding site [chemical binding]; other site 765952005702 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005704 NAD(P) binding site [chemical binding]; other site 765952005705 active site 765952005706 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952005707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952005708 EamA-like transporter family; Region: EamA; cl01037 765952005709 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 765952005710 EamA-like transporter family; Region: EamA; cl01037 765952005711 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765952005712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952005713 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 765952005714 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 765952005715 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 765952005716 active site 765952005717 NTP binding site [chemical binding]; other site 765952005718 metal binding triad [ion binding]; metal-binding site 765952005719 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 765952005720 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 765952005721 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765952005722 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 765952005723 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 765952005724 active site 765952005725 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 765952005726 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 765952005727 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 765952005728 DsbD alpha interface [polypeptide binding]; other site 765952005729 catalytic residues [active] 765952005730 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 765952005731 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 765952005732 translocation protein TolB; Provisional; Region: tolB; PRK01029 765952005733 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 765952005734 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 765952005735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952005736 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 765952005737 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 765952005738 dimer interface [polypeptide binding]; other site 765952005739 decamer (pentamer of dimers) interface [polypeptide binding]; other site 765952005740 catalytic triad [active] 765952005741 peroxidatic and resolving cysteines [active] 765952005742 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 765952005743 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005744 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005745 RHS Repeat; Region: RHS_repeat; cl11982 765952005746 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005747 transcriptional regulator InvF; Provisional; Region: PRK15340 765952005748 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 765952005749 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 765952005750 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 765952005751 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 765952005752 active site 765952005753 dimer interface [polypeptide binding]; other site 765952005754 motif 1; other site 765952005755 motif 2; other site 765952005756 motif 3; other site 765952005757 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 765952005758 anticodon binding site; other site 765952005759 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 765952005760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 765952005761 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 765952005762 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 765952005763 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 765952005764 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 765952005765 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 765952005766 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 765952005767 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 765952005768 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 765952005769 NAD binding site [chemical binding]; other site 765952005770 Phe binding site; other site 765952005771 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 765952005772 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 765952005773 Predicted GTPase [General function prediction only]; Region: COG0218 765952005774 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 765952005775 G1 box; other site 765952005776 GTP/Mg2+ binding site [chemical binding]; other site 765952005777 Switch I region; other site 765952005778 G2 box; other site 765952005779 G3 box; other site 765952005780 Switch II region; other site 765952005781 G4 box; other site 765952005782 G5 box; other site 765952005783 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 765952005784 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765952005785 active site 765952005786 catalytic site [active] 765952005787 substrate binding site [chemical binding]; other site 765952005788 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 765952005789 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 765952005790 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 765952005791 active site 765952005792 multimer interface [polypeptide binding]; other site 765952005793 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 765952005794 predicted active site [active] 765952005795 catalytic triad [active] 765952005796 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952005797 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 765952005798 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 765952005799 Probable Catalytic site; other site 765952005800 metal-binding site 765952005801 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 765952005802 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 765952005803 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 765952005804 AMP-binding enzyme; Region: AMP-binding; cl15778 765952005805 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765952005806 Condensation domain; Region: Condensation; pfam00668 765952005807 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 765952005808 thioester reductase domain; Region: Thioester-redct; TIGR01746 765952005809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005810 NAD(P) binding site [chemical binding]; other site 765952005811 active site 765952005812 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 765952005813 classical (c) SDRs; Region: SDR_c; cd05233 765952005814 NAD(P) binding site [chemical binding]; other site 765952005815 active site 765952005816 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 765952005817 AMP-binding enzyme; Region: AMP-binding; cl15778 765952005818 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765952005819 peptide synthase; Provisional; Region: PRK12316 765952005820 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 765952005821 AMP-binding enzyme; Region: AMP-binding; cl15778 765952005822 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765952005823 peptide synthase; Provisional; Region: PRK12467 765952005824 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 765952005825 AMP-binding enzyme; Region: AMP-binding; cl15778 765952005826 Phosphopantetheine attachment site; Region: PP-binding; cl09936 765952005827 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 765952005828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952005829 Coenzyme A binding pocket [chemical binding]; other site 765952005830 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 765952005831 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 765952005832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005833 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 765952005834 putative substrate translocation pore; other site 765952005835 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 765952005836 integrase; Provisional; Region: PRK09692 765952005837 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 765952005838 active site 765952005839 Int/Topo IB signature motif; other site 765952005840 BRO family, N-terminal domain; Region: Bro-N; cl10591 765952005841 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 765952005842 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 765952005843 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 765952005844 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 765952005845 active site