-- dump date 20120504_154634 -- class Genbank::misc_feature -- table misc_feature_note -- id note 278197000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 278197000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197000003 Walker A motif; other site 278197000004 ATP binding site [chemical binding]; other site 278197000005 Walker B motif; other site 278197000006 arginine finger; other site 278197000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 278197000008 DnaA box-binding interface [nucleotide binding]; other site 278197000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 278197000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 278197000011 putative DNA binding surface [nucleotide binding]; other site 278197000012 dimer interface [polypeptide binding]; other site 278197000013 beta-clamp/clamp loader binding surface; other site 278197000014 beta-clamp/translesion DNA polymerase binding surface; other site 278197000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 278197000016 recombination protein F; Reviewed; Region: recF; PRK00064 278197000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 278197000018 Walker A/P-loop; other site 278197000019 ATP binding site [chemical binding]; other site 278197000020 Q-loop/lid; other site 278197000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197000022 ABC transporter signature motif; other site 278197000023 Walker B; other site 278197000024 D-loop; other site 278197000025 H-loop/switch region; other site 278197000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 278197000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197000028 Mg2+ binding site [ion binding]; other site 278197000029 G-X-G motif; other site 278197000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 278197000031 anchoring element; other site 278197000032 dimer interface [polypeptide binding]; other site 278197000033 ATP binding site [chemical binding]; other site 278197000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 278197000035 active site 278197000036 metal binding site [ion binding]; metal-binding site 278197000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 278197000038 DNA gyrase subunit A; Validated; Region: PRK05560 278197000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 278197000040 CAP-like domain; other site 278197000041 active site 278197000042 primary dimer interface [polypeptide binding]; other site 278197000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000049 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 278197000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 278197000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278197000052 dimer interface [polypeptide binding]; other site 278197000053 ssDNA binding site [nucleotide binding]; other site 278197000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197000055 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 278197000056 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 278197000057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 278197000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 278197000059 DHH family; Region: DHH; pfam01368 278197000060 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 278197000061 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 278197000062 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 278197000063 replicative DNA helicase; Provisional; Region: PRK05748 278197000064 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 278197000065 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 278197000066 Walker A motif; other site 278197000067 ATP binding site [chemical binding]; other site 278197000068 Walker B motif; other site 278197000069 DNA binding loops [nucleotide binding] 278197000070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197000072 putative substrate translocation pore; other site 278197000073 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 278197000074 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278197000075 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 278197000076 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278197000077 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197000078 ABC transporter; Region: ABC_tran_2; pfam12848 278197000079 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197000080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197000081 Helix-turn-helix domains; Region: HTH; cl00088 278197000082 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197000083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197000084 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 278197000085 Walker A/P-loop; other site 278197000086 ATP binding site [chemical binding]; other site 278197000087 Q-loop/lid; other site 278197000088 ABC transporter signature motif; other site 278197000089 Walker B; other site 278197000090 D-loop; other site 278197000091 H-loop/switch region; other site 278197000092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197000093 non-specific DNA binding site [nucleotide binding]; other site 278197000094 salt bridge; other site 278197000095 sequence-specific DNA binding site [nucleotide binding]; other site 278197000096 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 278197000097 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197000098 Sterol carrier protein domain; Region: SCP2_2; pfam13530 278197000099 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197000100 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197000101 Helix-turn-helix domains; Region: HTH; cl00088 278197000102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000103 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000104 active site 278197000105 catalytic tetrad [active] 278197000106 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278197000107 classical (c) SDRs; Region: SDR_c; cd05233 278197000108 NAD(P) binding site [chemical binding]; other site 278197000109 active site 278197000110 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197000111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278197000112 dimerization interface [polypeptide binding]; other site 278197000113 putative DNA binding site [nucleotide binding]; other site 278197000114 putative Zn2+ binding site [ion binding]; other site 278197000115 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 278197000116 Cadmium resistance transporter; Region: Cad; cl04177 278197000117 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197000118 putative peptidoglycan binding site; other site 278197000119 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 278197000120 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 278197000121 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 278197000122 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 278197000123 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197000124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000125 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197000127 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 278197000128 Haemolysin-III related; Region: HlyIII; cl03831 278197000129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 278197000130 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197000131 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 278197000132 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 278197000133 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 278197000134 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 278197000135 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 278197000136 putative active site [active] 278197000137 catalytic site [active] 278197000138 putative metal binding site [ion binding]; other site 278197000139 Colicin V production protein; Region: Colicin_V; cl00567 278197000140 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 278197000141 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 278197000142 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 278197000143 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 278197000144 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197000145 Ligand Binding Site [chemical binding]; other site 278197000146 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 278197000147 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278197000148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197000149 Helix-turn-helix domains; Region: HTH; cl00088 278197000150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197000151 dimerization interface [polypeptide binding]; other site 278197000152 maltose O-acetyltransferase; Provisional; Region: PRK10092 278197000153 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 278197000154 trimer interface [polypeptide binding]; other site 278197000155 active site 278197000156 substrate binding site [chemical binding]; other site 278197000157 CoA binding site [chemical binding]; other site 278197000158 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278197000159 classical (c) SDRs; Region: SDR_c; cd05233 278197000160 NAD(P) binding site [chemical binding]; other site 278197000161 active site 278197000162 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000163 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000164 active site 278197000165 catalytic tetrad [active] 278197000166 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 278197000167 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 278197000168 Walker A/P-loop; other site 278197000169 ATP binding site [chemical binding]; other site 278197000170 Q-loop/lid; other site 278197000171 ABC transporter signature motif; other site 278197000172 Walker B; other site 278197000173 D-loop; other site 278197000174 H-loop/switch region; other site 278197000175 Predicted transcriptional regulators [Transcription]; Region: COG1725 278197000176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000177 DNA-binding site [nucleotide binding]; DNA binding site 278197000178 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 278197000179 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197000180 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 278197000181 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 278197000182 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 278197000183 active site 278197000184 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 278197000185 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 278197000186 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 278197000187 DNA binding residues [nucleotide binding] 278197000188 putative dimer interface [polypeptide binding]; other site 278197000189 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 278197000190 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000191 active site 278197000192 catalytic tetrad [active] 278197000193 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 278197000194 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 278197000195 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 278197000196 SecY translocase; Region: SecY; pfam00344 278197000197 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 278197000198 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 278197000199 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278197000200 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 278197000201 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 278197000202 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 278197000203 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 278197000204 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 278197000205 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 278197000206 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 278197000207 Gram positive anchor; Region: Gram_pos_anchor; cl15427 278197000208 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 278197000209 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 278197000210 glucose-1-dehydrogenase; Provisional; Region: PRK08936 278197000211 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 278197000212 NAD binding site [chemical binding]; other site 278197000213 homodimer interface [polypeptide binding]; other site 278197000214 active site 278197000215 Helix-turn-helix domains; Region: HTH; cl00088 278197000216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278197000217 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000218 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000219 active site 278197000220 catalytic tetrad [active] 278197000221 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 278197000222 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278197000223 catalytic Zn binding site [ion binding]; other site 278197000224 NAD(P) binding site [chemical binding]; other site 278197000225 structural Zn binding site [ion binding]; other site 278197000226 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 278197000227 HPr interaction site; other site 278197000228 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197000229 active site 278197000230 phosphorylation site [posttranslational modification] 278197000231 CAT RNA binding domain; Region: CAT_RBD; cl03904 278197000232 transcriptional antiterminator BglG; Provisional; Region: PRK09772 278197000233 PRD domain; Region: PRD; cl15445 278197000234 PRD domain; Region: PRD; cl15445 278197000235 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 278197000236 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197000237 active site turn [active] 278197000238 phosphorylation site [posttranslational modification] 278197000239 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197000240 YdjC-like protein; Region: YdjC; cl01344 278197000241 Enterocin A Immunity; Region: EntA_Immun; pfam08951 278197000242 Class II bacteriocin; Region: Bacteriocin_II; pfam01721 278197000243 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 278197000244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278197000245 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 278197000246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197000247 active site 278197000248 phosphorylation site [posttranslational modification] 278197000249 intermolecular recognition site; other site 278197000250 dimerization interface [polypeptide binding]; other site 278197000251 LytTr DNA-binding domain; Region: LytTR; cl04498 278197000252 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 278197000253 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 278197000254 putative active site [active] 278197000255 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278197000256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197000257 Walker A/P-loop; other site 278197000258 ATP binding site [chemical binding]; other site 278197000259 Q-loop/lid; other site 278197000260 ABC transporter signature motif; other site 278197000261 Walker B; other site 278197000262 D-loop; other site 278197000263 H-loop/switch region; other site 278197000264 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 278197000265 intersubunit interface [polypeptide binding]; other site 278197000266 putative acetyltransferase YhhY; Provisional; Region: PRK10140 278197000267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197000268 Coenzyme A binding pocket [chemical binding]; other site 278197000269 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 278197000270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197000271 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197000272 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197000273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197000274 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197000275 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000276 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000277 putative active site [active] 278197000278 putative oxidoreductase; Provisional; Region: PRK10206 278197000279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000280 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 278197000281 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278197000282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000283 maltose O-acetyltransferase; Provisional; Region: PRK10092 278197000284 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 278197000285 active site 278197000286 substrate binding site [chemical binding]; other site 278197000287 trimer interface [polypeptide binding]; other site 278197000288 CoA binding site [chemical binding]; other site 278197000289 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197000290 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 278197000291 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197000292 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 278197000293 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278197000294 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197000295 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278197000296 catalytic residues [active] 278197000297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197000298 N-glycosyltransferase; Provisional; Region: PRK11204 278197000299 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 278197000300 DXD motif; other site 278197000301 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197000302 hypothetical protein; Provisional; Region: PRK07329 278197000303 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 278197000304 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 278197000305 metal binding site [ion binding]; metal-binding site 278197000306 dimer interface [polypeptide binding]; other site 278197000307 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 278197000308 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000309 active site 278197000310 catalytic tetrad [active] 278197000311 galactokinase; Provisional; Region: PRK05322 278197000312 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 278197000313 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197000314 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197000315 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 278197000316 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 278197000317 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 278197000318 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 278197000319 MucBP domain; Region: MucBP; pfam06458 278197000320 MucBP domain; Region: MucBP; pfam06458 278197000321 MucBP domain; Region: MucBP; pfam06458 278197000322 MucBP domain; Region: MucBP; pfam06458 278197000323 MucBP domain; Region: MucBP; pfam06458 278197000324 MucBP domain; Region: MucBP; pfam06458 278197000325 MucBP domain; Region: MucBP; pfam06458 278197000326 MucBP domain; Region: MucBP; pfam06458 278197000327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 278197000328 CCC1-related family of proteins; Region: CCC1_like; cl00278 278197000329 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 278197000330 LytTr DNA-binding domain; Region: LytTR; cl04498 278197000331 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 278197000332 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197000333 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 278197000334 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 278197000335 DXD motif; other site 278197000336 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 278197000337 Collagen binding domain; Region: Collagen_bind; pfam05737 278197000338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000339 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197000340 putative substrate translocation pore; other site 278197000341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278197000342 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 278197000343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000344 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 278197000345 aromatic amino acid aminotransferase; Validated; Region: PRK07309 278197000346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278197000347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278197000348 homodimer interface [polypeptide binding]; other site 278197000349 catalytic residue [active] 278197000350 dihydrodipicolinate reductase; Provisional; Region: PRK00048 278197000351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000352 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 278197000353 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 278197000354 dihydrodipicolinate synthase; Region: dapA; TIGR00674 278197000355 dimer interface [polypeptide binding]; other site 278197000356 active site 278197000357 catalytic residue [active] 278197000358 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 278197000359 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 278197000360 metal binding site [ion binding]; metal-binding site 278197000361 putative dimer interface [polypeptide binding]; other site 278197000362 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 278197000363 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 278197000364 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278197000365 putative trimer interface [polypeptide binding]; other site 278197000366 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278197000367 putative trimer interface [polypeptide binding]; other site 278197000368 putative CoA binding site [chemical binding]; other site 278197000369 diaminopimelate decarboxylase; Region: lysA; TIGR01048 278197000370 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 278197000371 active site 278197000372 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278197000373 substrate binding site [chemical binding]; other site 278197000374 catalytic residues [active] 278197000375 dimer interface [polypeptide binding]; other site 278197000376 aspartate kinase; Reviewed; Region: PRK09034 278197000377 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 278197000378 putative catalytic residues [active] 278197000379 putative nucleotide binding site [chemical binding]; other site 278197000380 putative aspartate binding site [chemical binding]; other site 278197000381 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 278197000382 allosteric regulatory residue; other site 278197000383 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 278197000384 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 278197000385 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 278197000386 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 278197000387 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 278197000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000389 putative substrate translocation pore; other site 278197000390 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000391 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000392 putative active site [active] 278197000393 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 278197000394 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 278197000395 putative substrate binding site [chemical binding]; other site 278197000396 putative ATP binding site [chemical binding]; other site 278197000397 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 278197000398 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 278197000399 active site 278197000400 P-loop; other site 278197000401 phosphorylation site [posttranslational modification] 278197000402 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197000403 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278197000404 active site 278197000405 phosphorylation site [posttranslational modification] 278197000406 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278197000407 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 278197000408 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278197000409 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 278197000410 oxidoreductase; Provisional; Region: PRK07985 278197000411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000412 NAD(P) binding site [chemical binding]; other site 278197000413 active site 278197000414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 278197000415 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 278197000416 MgtC family; Region: MgtC; pfam02308 278197000417 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197000418 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000419 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000420 putative active site [active] 278197000421 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 278197000422 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 278197000423 putative active site cavity [active] 278197000424 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 278197000425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000427 Cupin domain; Region: Cupin_2; cl09118 278197000428 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197000429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197000430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 278197000431 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 278197000432 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 278197000433 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197000434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000435 DNA-binding site [nucleotide binding]; DNA binding site 278197000436 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 278197000437 putative dimerization interface [polypeptide binding]; other site 278197000438 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 278197000439 putative ligand binding site [chemical binding]; other site 278197000440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000441 DNA-binding site [nucleotide binding]; DNA binding site 278197000442 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 278197000443 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 278197000444 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 278197000445 active site 278197000446 tetramer interface [polypeptide binding]; other site 278197000447 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 278197000448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000449 putative substrate translocation pore; other site 278197000450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000451 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 278197000452 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 278197000453 putative N- and C-terminal domain interface [polypeptide binding]; other site 278197000454 putative active site [active] 278197000455 putative MgATP binding site [chemical binding]; other site 278197000456 catalytic site [active] 278197000457 metal binding site [ion binding]; metal-binding site 278197000458 putative carbohydrate binding site [chemical binding]; other site 278197000459 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 278197000460 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 278197000461 intersubunit interface [polypeptide binding]; other site 278197000462 active site 278197000463 Zn2+ binding site [ion binding]; other site 278197000464 L-arabinose isomerase; Provisional; Region: PRK02929 278197000465 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 278197000466 hexamer (dimer of trimers) interface [polypeptide binding]; other site 278197000467 trimer interface [polypeptide binding]; other site 278197000468 substrate binding site [chemical binding]; other site 278197000469 Mn binding site [ion binding]; other site 278197000470 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 278197000471 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 278197000472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000473 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 278197000474 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 278197000475 tetramer interface [polypeptide binding]; other site 278197000476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278197000477 catalytic residue [active] 278197000478 OPT oligopeptide transporter protein; Region: OPT; cl14607 278197000479 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 278197000480 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 278197000481 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197000482 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 278197000483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000484 DNA-binding site [nucleotide binding]; DNA binding site 278197000485 UTRA domain; Region: UTRA; cl01230 278197000486 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197000487 active site 278197000488 phosphorylation site [posttranslational modification] 278197000489 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 278197000490 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 278197000491 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 278197000492 active pocket/dimerization site; other site 278197000493 active site 278197000494 phosphorylation site [posttranslational modification] 278197000495 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000497 DNA-binding site [nucleotide binding]; DNA binding site 278197000498 UTRA domain; Region: UTRA; cl01230 278197000499 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000501 DNA-binding site [nucleotide binding]; DNA binding site 278197000502 UTRA domain; Region: UTRA; cl01230 278197000503 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 278197000504 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 278197000505 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 278197000506 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 278197000507 catalytic Zn binding site [ion binding]; other site 278197000508 NAD binding site [chemical binding]; other site 278197000509 structural Zn binding site [ion binding]; other site 278197000510 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197000511 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197000512 putative alpha-glucosidase; Provisional; Region: PRK10658 278197000513 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 278197000514 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 278197000515 active site 278197000516 homotrimer interface [polypeptide binding]; other site 278197000517 catalytic site [active] 278197000518 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 278197000519 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197000520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000521 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197000522 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197000523 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 278197000524 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 278197000525 N- and C-terminal domain interface [polypeptide binding]; other site 278197000526 D-xylulose kinase; Region: XylB; TIGR01312 278197000527 active site 278197000528 catalytic site [active] 278197000529 metal binding site [ion binding]; metal-binding site 278197000530 xylulose binding site [chemical binding]; other site 278197000531 putative ATP binding site [chemical binding]; other site 278197000532 homodimer interface [polypeptide binding]; other site 278197000533 putrescine carbamoyltransferase; Provisional; Region: PRK02255 278197000534 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278197000535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000536 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 278197000537 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 278197000538 agmatine deiminase; Region: agmatine_aguA; TIGR03380 278197000539 carbamate kinase; Reviewed; Region: PRK12686 278197000540 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 278197000541 putative substrate binding site [chemical binding]; other site 278197000542 nucleotide binding site [chemical binding]; other site 278197000543 nucleotide binding site [chemical binding]; other site 278197000544 homodimer interface [polypeptide binding]; other site 278197000545 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 278197000546 agmatine deiminase; Region: agmatine_aguA; TIGR03380 278197000547 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000548 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000549 putative active site [active] 278197000550 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 278197000551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197000552 Walker A motif; other site 278197000553 ATP binding site [chemical binding]; other site 278197000554 Walker B motif; other site 278197000555 arginine finger; other site 278197000556 Transcriptional antiterminator [Transcription]; Region: COG3933 278197000557 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 278197000558 active pocket/dimerization site; other site 278197000559 active site 278197000560 phosphorylation site [posttranslational modification] 278197000561 PRD domain; Region: PRD; cl15445 278197000562 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 278197000563 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 278197000564 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 278197000565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197000566 DNA binding site [nucleotide binding] 278197000567 domain linker motif; other site 278197000568 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 278197000569 putative dimerization interface [polypeptide binding]; other site 278197000570 putative ligand binding site [chemical binding]; other site 278197000571 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 278197000572 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 278197000573 active site 278197000574 catalytic residues [active] 278197000575 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 278197000576 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197000577 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 278197000578 HPr interaction site; other site 278197000579 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197000580 active site 278197000581 phosphorylation site [posttranslational modification] 278197000582 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 278197000583 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 278197000584 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 278197000585 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 278197000586 galactokinase; Provisional; Region: PRK05322 278197000587 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 278197000588 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197000589 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197000590 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 278197000591 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 278197000592 NAD binding site [chemical binding]; other site 278197000593 homodimer interface [polypeptide binding]; other site 278197000594 active site 278197000595 substrate binding site [chemical binding]; other site 278197000596 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 278197000597 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 278197000598 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 278197000599 fumarate hydratase; Reviewed; Region: fumC; PRK00485 278197000600 Class II fumarases; Region: Fumarase_classII; cd01362 278197000601 active site 278197000602 tetramer interface [polypeptide binding]; other site 278197000603 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 278197000604 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 278197000605 transmembrane helices; other site 278197000606 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 278197000607 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 278197000608 active site 278197000609 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 278197000610 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 278197000611 active site 278197000612 nucleophile elbow; other site 278197000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000614 putative substrate translocation pore; other site 278197000615 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 278197000616 Helix-turn-helix domains; Region: HTH; cl00088 278197000617 3H domain; Region: 3H; pfam02829 278197000618 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 278197000619 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 278197000620 Ligand binding site; other site 278197000621 metal-binding site 278197000622 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 278197000623 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 278197000624 Ligand binding site; other site 278197000625 metal-binding site 278197000626 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 278197000627 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197000628 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 278197000629 NAD binding site [chemical binding]; other site 278197000630 dimer interface [polypeptide binding]; other site 278197000631 substrate binding site [chemical binding]; other site 278197000632 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 278197000633 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 278197000634 putative active site [active] 278197000635 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 278197000636 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 278197000637 active site 278197000638 catalytic residues [active] 278197000639 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 278197000640 EamA-like transporter family; Region: EamA; cl01037 278197000641 EamA-like transporter family; Region: EamA; cl01037 278197000642 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 278197000643 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 278197000644 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 278197000645 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 278197000646 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 278197000647 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 278197000648 dimer interface [polypeptide binding]; other site 278197000649 FMN binding site [chemical binding]; other site 278197000650 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 278197000651 dimer interface [polypeptide binding]; other site 278197000652 substrate binding site [chemical binding]; other site 278197000653 ATP binding site [chemical binding]; other site 278197000654 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 278197000655 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 278197000656 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197000657 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197000658 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 278197000659 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197000660 putative NAD(P) binding site [chemical binding]; other site 278197000661 dipeptidase PepV; Reviewed; Region: PRK07318 278197000662 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 278197000663 active site 278197000664 metal binding site [ion binding]; metal-binding site 278197000665 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 278197000666 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 278197000667 active site 278197000668 HIGH motif; other site 278197000669 dimer interface [polypeptide binding]; other site 278197000670 KMSKS motif; other site 278197000671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 278197000672 Sodium:solute symporter family; Region: SSF; cl00456 278197000673 cytosine deaminase; Provisional; Region: PRK09230 278197000674 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 278197000675 active site 278197000676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197000677 ABC-ATPase subunit interface; other site 278197000678 NMT1-like family; Region: NMT1_2; cl15260 278197000679 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 278197000680 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 278197000681 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197000682 Walker A/P-loop; other site 278197000683 ATP binding site [chemical binding]; other site 278197000684 Q-loop/lid; other site 278197000685 ABC transporter signature motif; other site 278197000686 Walker B; other site 278197000687 D-loop; other site 278197000688 H-loop/switch region; other site 278197000689 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 278197000690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000691 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000692 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 278197000693 pyruvate carboxylase; Reviewed; Region: PRK12999 278197000694 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197000695 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197000696 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 278197000697 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 278197000698 active site 278197000699 catalytic residues [active] 278197000700 metal binding site [ion binding]; metal-binding site 278197000701 homodimer binding site [polypeptide binding]; other site 278197000702 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278197000703 carboxyltransferase (CT) interaction site; other site 278197000704 biotinylation site [posttranslational modification]; other site 278197000705 aspartate aminotransferase; Provisional; Region: PRK05764 278197000706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278197000707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278197000708 homodimer interface [polypeptide binding]; other site 278197000709 catalytic residue [active] 278197000710 Protein of unknown function (DUF554); Region: DUF554; cl00784 278197000711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197000712 Helix-turn-helix domains; Region: HTH; cl00088 278197000713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197000714 dimerization interface [polypeptide binding]; other site 278197000715 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 278197000716 aromatic acid decarboxylase; Validated; Region: PRK05920 278197000717 Flavoprotein; Region: Flavoprotein; cl08021 278197000718 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278197000719 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 278197000720 putative NAD(P) binding site [chemical binding]; other site 278197000721 Protein of unknown function, DUF606; Region: DUF606; cl01273 278197000722 Protein of unknown function, DUF606; Region: DUF606; cl01273 278197000723 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 278197000724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197000725 Family description; Region: UvrD_C_2; cl15862 278197000726 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 278197000727 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 278197000728 active site 278197000729 HIGH motif; other site 278197000730 dimer interface [polypeptide binding]; other site 278197000731 KMSKS motif; other site 278197000732 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 278197000733 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 278197000734 homodimer interface [polypeptide binding]; other site 278197000735 catalytic residues [active] 278197000736 NAD binding site [chemical binding]; other site 278197000737 substrate binding pocket [chemical binding]; other site 278197000738 flexible flap; other site 278197000739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197000740 non-specific DNA binding site [nucleotide binding]; other site 278197000741 salt bridge; other site 278197000742 sequence-specific DNA binding site [nucleotide binding]; other site 278197000743 PspC domain; Region: PspC; cl00864 278197000744 Protein of unknown function DUF72; Region: DUF72; cl00777 278197000745 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 278197000746 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 278197000747 HIGH motif; other site 278197000748 active site 278197000749 KMSKS motif; other site 278197000750 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 278197000751 tRNA binding surface [nucleotide binding]; other site 278197000752 anticodon binding site; other site 278197000753 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 278197000754 dimer interface [polypeptide binding]; other site 278197000755 putative tRNA-binding site [nucleotide binding]; other site 278197000756 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 278197000757 active site 278197000758 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 278197000759 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 278197000760 putative active site [active] 278197000761 putative metal binding site [ion binding]; other site 278197000762 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 278197000763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000764 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 278197000765 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 278197000766 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197000767 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197000768 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 278197000769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197000770 Ligand Binding Site [chemical binding]; other site 278197000771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197000772 Ligand Binding Site [chemical binding]; other site 278197000773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197000775 putative substrate translocation pore; other site 278197000776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000777 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 278197000778 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 278197000779 dimer interface [polypeptide binding]; other site 278197000780 active site 278197000781 metal binding site [ion binding]; metal-binding site 278197000782 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 278197000783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197000784 Walker A/P-loop; other site 278197000785 ATP binding site [chemical binding]; other site 278197000786 Q-loop/lid; other site 278197000787 ABC transporter signature motif; other site 278197000788 Walker B; other site 278197000789 D-loop; other site 278197000790 H-loop/switch region; other site 278197000791 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 278197000792 TM-ABC transporter signature motif; other site 278197000793 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 278197000794 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 278197000795 zinc binding site [ion binding]; other site 278197000796 putative ligand binding site [chemical binding]; other site 278197000797 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000799 DNA-binding site [nucleotide binding]; DNA binding site 278197000800 UTRA domain; Region: UTRA; cl01230 278197000801 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 278197000802 active site 278197000803 P-loop; other site 278197000804 phosphorylation site [posttranslational modification] 278197000805 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 278197000806 active site 278197000807 methionine cluster; other site 278197000808 phosphorylation site [posttranslational modification] 278197000809 metal binding site [ion binding]; metal-binding site 278197000810 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197000811 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000812 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000813 putative active site [active] 278197000814 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197000815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000816 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000817 acetoin reductase; Validated; Region: PRK08643 278197000818 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 278197000819 NAD binding site [chemical binding]; other site 278197000820 homotetramer interface [polypeptide binding]; other site 278197000821 homodimer interface [polypeptide binding]; other site 278197000822 active site 278197000823 substrate binding site [chemical binding]; other site 278197000824 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 278197000825 putative uracil binding site [chemical binding]; other site 278197000826 putative active site [active] 278197000827 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197000828 Sterol carrier protein domain; Region: SCP2_2; pfam13530 278197000829 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 278197000830 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 278197000831 metal binding site [ion binding]; metal-binding site 278197000832 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 278197000833 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 278197000834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 278197000835 ABC-ATPase subunit interface; other site 278197000836 dimer interface [polypeptide binding]; other site 278197000837 putative PBP binding regions; other site 278197000838 pur operon repressor; Provisional; Region: PRK09213 278197000839 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 278197000840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197000841 active site 278197000842 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 278197000843 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 278197000844 Substrate binding site; other site 278197000845 Mg++ binding site; other site 278197000846 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 278197000847 active site 278197000848 substrate binding site [chemical binding]; other site 278197000849 CoA binding site [chemical binding]; other site 278197000850 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 278197000851 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 278197000852 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 278197000853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197000854 active site 278197000855 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 278197000856 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 278197000857 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 278197000858 amphipathic channel; other site 278197000859 Asn-Pro-Ala signature motifs; other site 278197000860 Ion transport protein; Region: Ion_trans; pfam00520 278197000861 Ion channel; Region: Ion_trans_2; cl11596 278197000862 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 278197000863 active site 278197000864 homotetramer interface [polypeptide binding]; other site 278197000865 homodimer interface [polypeptide binding]; other site 278197000866 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 278197000867 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 278197000868 active site 278197000869 Zn binding site [ion binding]; other site 278197000870 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 278197000871 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 278197000872 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 278197000873 RNA/DNA hybrid binding site [nucleotide binding]; other site 278197000874 active site 278197000875 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197000876 Helix-turn-helix domains; Region: HTH; cl00088 278197000877 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 278197000878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197000879 dimerization interface [polypeptide binding]; other site 278197000880 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 278197000881 Membrane transport protein; Region: Mem_trans; cl09117 278197000882 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197000883 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197000884 active site 278197000885 motif I; other site 278197000886 motif II; other site 278197000887 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197000888 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 278197000889 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278197000890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000891 dihydroorotase; Validated; Region: pyrC; PRK09357 278197000892 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 278197000893 active site 278197000894 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 278197000895 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 278197000896 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 278197000897 catalytic site [active] 278197000898 subunit interface [polypeptide binding]; other site 278197000899 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 278197000900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197000901 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197000902 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 278197000903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197000904 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197000905 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 278197000906 IMP binding site; other site 278197000907 dimer interface [polypeptide binding]; other site 278197000908 interdomain contacts; other site 278197000909 partial ornithine binding site; other site 278197000910 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 278197000911 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 278197000912 heterodimer interface [polypeptide binding]; other site 278197000913 active site 278197000914 FMN binding site [chemical binding]; other site 278197000915 homodimer interface [polypeptide binding]; other site 278197000916 substrate binding site [chemical binding]; other site 278197000917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000918 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 278197000919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000920 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 278197000921 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 278197000922 N-glycosyltransferase; Provisional; Region: PRK11204 278197000923 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 278197000924 DXD motif; other site 278197000925 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 278197000926 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 278197000927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278197000928 putative metal binding site [ion binding]; other site 278197000929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197000930 Helix-turn-helix domains; Region: HTH; cl00088 278197000931 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278197000932 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 278197000933 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197000934 NAD binding site [chemical binding]; other site 278197000935 substrate binding site [chemical binding]; other site 278197000936 putative active site [active] 278197000937 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 278197000938 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 278197000939 Walker A/P-loop; other site 278197000940 ATP binding site [chemical binding]; other site 278197000941 Q-loop/lid; other site 278197000942 ABC transporter signature motif; other site 278197000943 Walker B; other site 278197000944 D-loop; other site 278197000945 H-loop/switch region; other site 278197000946 NMT1-like family; Region: NMT1_2; cl15260 278197000947 NMT1/THI5 like; Region: NMT1; pfam09084 278197000948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197000949 dimer interface [polypeptide binding]; other site 278197000950 conserved gate region; other site 278197000951 putative PBP binding loops; other site 278197000952 ABC-ATPase subunit interface; other site 278197000953 Domain of unknown function DUF77; Region: DUF77; cl00307 278197000954 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 278197000955 active site 278197000956 trimer interface [polypeptide binding]; other site 278197000957 allosteric site; other site 278197000958 active site lid [active] 278197000959 hexamer (dimer of trimers) interface [polypeptide binding]; other site 278197000960 Acetokinase family; Region: Acetate_kinase; cl01029 278197000961 propionate/acetate kinase; Provisional; Region: PRK12379 278197000962 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 278197000963 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 278197000964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 278197000965 metal binding site 2 [ion binding]; metal-binding site 278197000966 putative DNA binding helix; other site 278197000967 metal binding site 1 [ion binding]; metal-binding site 278197000968 dimer interface [polypeptide binding]; other site 278197000969 structural Zn2+ binding site [ion binding]; other site 278197000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278197000971 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197000972 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 278197000973 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 278197000974 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 278197000975 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 278197000976 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 278197000977 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 278197000978 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 278197000979 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 278197000980 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197000981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197000982 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197000983 active site 278197000984 motif I; other site 278197000985 motif II; other site 278197000986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197000987 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 278197000988 Domain of unknown function DUF21; Region: DUF21; pfam01595 278197000989 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278197000990 Transporter associated domain; Region: CorC_HlyC; cl08393 278197000991 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000992 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000993 active site 278197000994 catalytic tetrad [active] 278197000995 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 278197000996 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 278197000997 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 278197000998 putative deacylase active site [active] 278197000999 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197001000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197001001 DNA-binding site [nucleotide binding]; DNA binding site 278197001002 UTRA domain; Region: UTRA; cl01230 278197001003 putative phosphoketolase; Provisional; Region: PRK05261 278197001004 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 278197001005 TPP-binding site; other site 278197001006 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 278197001007 XFP C-terminal domain; Region: XFP_C; pfam09363 278197001008 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 278197001009 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 278197001010 active site 278197001011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197001012 Ligand Binding Site [chemical binding]; other site 278197001013 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 278197001014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001015 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278197001016 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278197001017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197001018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197001019 non-specific DNA binding site [nucleotide binding]; other site 278197001020 salt bridge; other site 278197001021 sequence-specific DNA binding site [nucleotide binding]; other site 278197001022 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197001023 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 278197001024 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 278197001025 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 278197001026 active site 278197001027 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 278197001028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197001030 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 278197001031 Sulfatase; Region: Sulfatase; cl10460 278197001032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001033 Coenzyme A binding pocket [chemical binding]; other site 278197001034 YibE/F-like protein; Region: YibE_F; cl02259 278197001035 YibE/F-like protein; Region: YibE_F; cl02259 278197001036 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 278197001037 Integral membrane protein TerC family; Region: TerC; cl10468 278197001038 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278197001039 catalytic residues [active] 278197001040 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278197001041 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 278197001042 active site 278197001043 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 278197001044 dimer interface [polypeptide binding]; other site 278197001045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278197001046 metal binding site [ion binding]; metal-binding site 278197001047 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278197001048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001049 Walker A/P-loop; other site 278197001050 ATP binding site [chemical binding]; other site 278197001051 Q-loop/lid; other site 278197001052 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197001053 ABC transporter signature motif; other site 278197001054 Walker B; other site 278197001055 D-loop; other site 278197001056 ABC transporter; Region: ABC_tran_2; pfam12848 278197001057 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197001058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197001059 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197001060 active site 278197001061 catalytic tetrad [active] 278197001062 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 278197001063 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197001064 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 278197001065 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 278197001066 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 278197001067 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 278197001068 amino acid transporter; Region: 2A0306; TIGR00909 278197001069 Spore germination protein; Region: Spore_permease; cl15802 278197001070 Spore germination protein; Region: Spore_permease; cl15802 278197001071 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 278197001072 active site 278197001073 Ap4A binding cleft/pocket [chemical binding]; other site 278197001074 P4 phosphate binding site; other site 278197001075 nudix motif; other site 278197001076 putative P2/P3 phosphate binding site [ion binding]; other site 278197001077 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 278197001078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001079 active site 278197001080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001081 ferric uptake regulator; Provisional; Region: fur; PRK09462 278197001082 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 278197001083 metal binding site 2 [ion binding]; metal-binding site 278197001084 putative DNA binding helix; other site 278197001085 metal binding site 1 [ion binding]; metal-binding site 278197001086 dimer interface [polypeptide binding]; other site 278197001087 structural Zn2+ binding site [ion binding]; other site 278197001088 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278197001089 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278197001090 Walker A/P-loop; other site 278197001091 ATP binding site [chemical binding]; other site 278197001092 Q-loop/lid; other site 278197001093 ABC transporter signature motif; other site 278197001094 Walker B; other site 278197001095 D-loop; other site 278197001096 H-loop/switch region; other site 278197001097 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197001098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197001099 substrate binding pocket [chemical binding]; other site 278197001100 membrane-bound complex binding site; other site 278197001101 hinge residues; other site 278197001102 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001104 dimer interface [polypeptide binding]; other site 278197001105 conserved gate region; other site 278197001106 putative PBP binding loops; other site 278197001107 ABC-ATPase subunit interface; other site 278197001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001109 dimer interface [polypeptide binding]; other site 278197001110 conserved gate region; other site 278197001111 putative PBP binding loops; other site 278197001112 ABC-ATPase subunit interface; other site 278197001113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197001114 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197001115 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 278197001116 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197001117 DNA binding residues [nucleotide binding] 278197001118 drug binding residues [chemical binding]; other site 278197001119 dimer interface [polypeptide binding]; other site 278197001120 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 278197001121 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 278197001122 HflX GTPase family; Region: HflX; cd01878 278197001123 G1 box; other site 278197001124 GTP/Mg2+ binding site [chemical binding]; other site 278197001125 Switch I region; other site 278197001126 G2 box; other site 278197001127 G3 box; other site 278197001128 Switch II region; other site 278197001129 G4 box; other site 278197001130 G5 box; other site 278197001131 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 278197001132 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 278197001133 peptide binding site [polypeptide binding]; other site 278197001134 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 278197001135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001136 dimer interface [polypeptide binding]; other site 278197001137 conserved gate region; other site 278197001138 putative PBP binding loops; other site 278197001139 ABC-ATPase subunit interface; other site 278197001140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 278197001141 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 278197001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001143 dimer interface [polypeptide binding]; other site 278197001144 conserved gate region; other site 278197001145 putative PBP binding loops; other site 278197001146 ABC-ATPase subunit interface; other site 278197001147 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 278197001148 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278197001149 Walker A/P-loop; other site 278197001150 ATP binding site [chemical binding]; other site 278197001151 Q-loop/lid; other site 278197001152 ABC transporter signature motif; other site 278197001153 Walker B; other site 278197001154 D-loop; other site 278197001155 H-loop/switch region; other site 278197001156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 278197001157 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 278197001158 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278197001159 Walker A/P-loop; other site 278197001160 ATP binding site [chemical binding]; other site 278197001161 Q-loop/lid; other site 278197001162 ABC transporter signature motif; other site 278197001163 Walker B; other site 278197001164 D-loop; other site 278197001165 H-loop/switch region; other site 278197001166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 278197001167 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197001168 catalytic core [active] 278197001169 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 278197001170 Amino acid permease; Region: AA_permease_2; pfam13520 278197001171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197001172 catalytic core [active] 278197001173 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197001174 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 278197001175 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001176 Family description; Region: UvrD_C_2; cl15862 278197001177 acetolactate synthase; Reviewed; Region: PRK08617 278197001178 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 278197001179 PYR/PP interface [polypeptide binding]; other site 278197001180 dimer interface [polypeptide binding]; other site 278197001181 TPP binding site [chemical binding]; other site 278197001182 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278197001183 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 278197001184 TPP-binding site [chemical binding]; other site 278197001185 dimer interface [polypeptide binding]; other site 278197001186 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 278197001187 pantothenate kinase; Provisional; Region: PRK05439 278197001188 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 278197001189 ATP-binding site [chemical binding]; other site 278197001190 CoA-binding site [chemical binding]; other site 278197001191 Mg2+-binding site [ion binding]; other site 278197001192 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278197001193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278197001194 ligand binding site [chemical binding]; other site 278197001195 flexible hinge region; other site 278197001196 Helix-turn-helix domains; Region: HTH; cl00088 278197001197 putative switch regulator; other site 278197001198 non-specific DNA interactions [nucleotide binding]; other site 278197001199 DNA binding site [nucleotide binding] 278197001200 sequence specific DNA binding site [nucleotide binding]; other site 278197001201 putative cAMP binding site [chemical binding]; other site 278197001202 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 278197001203 metal-binding site [ion binding] 278197001204 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 278197001205 dimerization interface [polypeptide binding]; other site 278197001206 DPS ferroxidase diiron center [ion binding]; other site 278197001207 ion pore; other site 278197001208 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 278197001209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197001210 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197001211 GMP synthase; Reviewed; Region: guaA; PRK00074 278197001212 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 278197001213 AMP/PPi binding site [chemical binding]; other site 278197001214 candidate oxyanion hole; other site 278197001215 catalytic triad [active] 278197001216 potential glutamine specificity residues [chemical binding]; other site 278197001217 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 278197001218 ATP Binding subdomain [chemical binding]; other site 278197001219 Dimerization subdomain; other site 278197001220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197001221 non-specific DNA binding site [nucleotide binding]; other site 278197001222 salt bridge; other site 278197001223 sequence-specific DNA binding site [nucleotide binding]; other site 278197001224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197001226 putative substrate translocation pore; other site 278197001227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001228 Peptidase family M1; Region: Peptidase_M1; pfam01433 278197001229 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 278197001230 Zn binding site [ion binding]; other site 278197001231 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 278197001232 CAAX protease self-immunity; Region: Abi; cl00558 278197001233 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 278197001234 oligomerisation interface [polypeptide binding]; other site 278197001235 mobile loop; other site 278197001236 roof hairpin; other site 278197001237 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 278197001238 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 278197001239 ring oligomerisation interface [polypeptide binding]; other site 278197001240 ATP/Mg binding site [chemical binding]; other site 278197001241 stacking interactions; other site 278197001242 hinge regions; other site 278197001243 Amino acid permease; Region: AA_permease_2; pfam13520 278197001244 K+ potassium transporter; Region: K_trans; cl15781 278197001245 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 278197001246 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 278197001247 Mg++ binding site [ion binding]; other site 278197001248 putative catalytic motif [active] 278197001249 substrate binding site [chemical binding]; other site 278197001250 Uncharacterized conserved protein [Function unknown]; Region: COG1739 278197001251 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 278197001252 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 278197001253 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 278197001254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197001255 ATP binding site [chemical binding]; other site 278197001256 putative Mg++ binding site [ion binding]; other site 278197001257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001258 nucleotide binding region [chemical binding]; other site 278197001259 ATP-binding site [chemical binding]; other site 278197001260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197001261 active site 278197001262 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 278197001263 30S subunit binding site; other site 278197001264 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 278197001265 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 278197001266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001267 nucleotide binding region [chemical binding]; other site 278197001268 ATP-binding site [chemical binding]; other site 278197001269 peptide chain release factor 2; Validated; Region: prfB; PRK00578 278197001270 RF-1 domain; Region: RF-1; cl02875 278197001271 RF-1 domain; Region: RF-1; cl02875 278197001272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197001273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197001274 active site 278197001275 phosphorylation site [posttranslational modification] 278197001276 intermolecular recognition site; other site 278197001277 dimerization interface [polypeptide binding]; other site 278197001278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197001279 DNA binding site [nucleotide binding] 278197001280 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 278197001281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197001282 dimer interface [polypeptide binding]; other site 278197001283 phosphorylation site [posttranslational modification] 278197001284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197001285 ATP binding site [chemical binding]; other site 278197001286 Mg2+ binding site [ion binding]; other site 278197001287 G-X-G motif; other site 278197001288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197001289 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 278197001290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001291 dimer interface [polypeptide binding]; other site 278197001292 conserved gate region; other site 278197001293 putative PBP binding loops; other site 278197001294 ABC-ATPase subunit interface; other site 278197001295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001296 dimer interface [polypeptide binding]; other site 278197001297 conserved gate region; other site 278197001298 putative PBP binding loops; other site 278197001299 ABC-ATPase subunit interface; other site 278197001300 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 278197001301 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 278197001302 Walker A/P-loop; other site 278197001303 ATP binding site [chemical binding]; other site 278197001304 Q-loop/lid; other site 278197001305 ABC transporter signature motif; other site 278197001306 Walker B; other site 278197001307 D-loop; other site 278197001308 H-loop/switch region; other site 278197001309 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 278197001310 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 278197001311 Walker A/P-loop; other site 278197001312 ATP binding site [chemical binding]; other site 278197001313 Q-loop/lid; other site 278197001314 ABC transporter signature motif; other site 278197001315 Walker B; other site 278197001316 D-loop; other site 278197001317 H-loop/switch region; other site 278197001318 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 278197001319 PhoU domain; Region: PhoU; pfam01895 278197001320 PhoU domain; Region: PhoU; pfam01895 278197001321 PspC domain; Region: PspC; cl00864 278197001322 Membrane protein of unknown function; Region: DUF360; cl00850 278197001323 HPr kinase/phosphorylase; Provisional; Region: PRK05428 278197001324 DRTGG domain; Region: DRTGG; cl12147 278197001325 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 278197001326 Hpr binding site; other site 278197001327 active site 278197001328 homohexamer subunit interaction site [polypeptide binding]; other site 278197001329 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 278197001330 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 278197001331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001332 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 278197001333 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 278197001334 active site 278197001335 tetramer interface; other site 278197001336 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 278197001337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197001339 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 278197001340 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 278197001341 active site 278197001342 substrate binding site [chemical binding]; other site 278197001343 metal binding site [ion binding]; metal-binding site 278197001344 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197001345 excinuclease ABC subunit B; Provisional; Region: PRK05298 278197001346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197001347 ATP binding site [chemical binding]; other site 278197001348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001349 nucleotide binding region [chemical binding]; other site 278197001350 ATP-binding site [chemical binding]; other site 278197001351 Ultra-violet resistance protein B; Region: UvrB; pfam12344 278197001352 UvrB/uvrC motif; Region: UVR; pfam02151 278197001353 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 278197001354 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 278197001355 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 278197001356 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 278197001357 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 278197001358 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 278197001359 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 278197001360 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 278197001361 putative substrate binding pocket [chemical binding]; other site 278197001362 dimer interface [polypeptide binding]; other site 278197001363 phosphate binding site [ion binding]; other site 278197001364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 278197001365 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 278197001366 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 278197001367 amidase catalytic site [active] 278197001368 Zn binding residues [ion binding]; other site 278197001369 substrate binding site [chemical binding]; other site 278197001370 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278197001371 Clp protease; Region: CLP_protease; pfam00574 278197001372 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 278197001373 oligomer interface [polypeptide binding]; other site 278197001374 active site residues [active] 278197001375 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 278197001376 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 278197001377 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 278197001378 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 278197001379 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 278197001380 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 278197001381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001382 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 278197001383 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 278197001384 Phosphoglycerate kinase; Region: PGK; pfam00162 278197001385 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 278197001386 substrate binding site [chemical binding]; other site 278197001387 hinge regions; other site 278197001388 ADP binding site [chemical binding]; other site 278197001389 catalytic site [active] 278197001390 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 278197001391 substrate binding site [chemical binding]; other site 278197001392 dimer interface [polypeptide binding]; other site 278197001393 catalytic triad [active] 278197001394 enolase; Provisional; Region: eno; PRK00077 278197001395 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 278197001396 dimer interface [polypeptide binding]; other site 278197001397 metal binding site [ion binding]; metal-binding site 278197001398 substrate binding pocket [chemical binding]; other site 278197001399 Preprotein translocase SecG subunit; Region: SecG; cl09123 278197001400 ribonuclease R; Region: RNase_R; TIGR02063 278197001401 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278197001402 RNB domain; Region: RNB; pfam00773 278197001403 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 278197001404 RNA binding site [nucleotide binding]; other site 278197001405 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 278197001406 SmpB-tmRNA interface; other site 278197001407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197001408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001409 Coenzyme A binding pocket [chemical binding]; other site 278197001410 Scramblase; Region: Scramblase; cl02043 278197001411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001412 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197001413 active site 278197001414 motif I; other site 278197001415 motif II; other site 278197001416 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197001417 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 278197001418 ligand binding site [chemical binding]; other site 278197001419 active site 278197001420 UGI interface [polypeptide binding]; other site 278197001421 catalytic site [active] 278197001422 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 278197001423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197001424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001425 Coenzyme A binding pocket [chemical binding]; other site 278197001426 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197001427 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 278197001428 active site 278197001429 catalytic site [active] 278197001430 substrate binding site [chemical binding]; other site 278197001431 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278197001432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001433 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 278197001434 FAD binding domain; Region: FAD_binding_4; pfam01565 278197001435 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 278197001436 Uncharacterized conserved protein [Function unknown]; Region: COG1624 278197001437 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 278197001438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 278197001439 YbbR-like protein; Region: YbbR; pfam07949 278197001440 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 278197001441 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 278197001442 active site 278197001443 substrate binding site [chemical binding]; other site 278197001444 metal binding site [ion binding]; metal-binding site 278197001445 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 278197001446 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 278197001447 glutaminase active site [active] 278197001448 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 278197001449 dimer interface [polypeptide binding]; other site 278197001450 active site 278197001451 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 278197001452 dimer interface [polypeptide binding]; other site 278197001453 active site 278197001454 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 278197001455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001456 motif II; other site 278197001457 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 278197001458 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 278197001459 Class III ribonucleotide reductase; Region: RNR_III; cd01675 278197001460 effector binding site; other site 278197001461 active site 278197001462 Zn binding site [ion binding]; other site 278197001463 glycine loop; other site 278197001464 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 278197001465 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 278197001466 FeS assembly ATPase SufC; Region: sufC; TIGR01978 278197001467 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 278197001468 Walker A/P-loop; other site 278197001469 ATP binding site [chemical binding]; other site 278197001470 Q-loop/lid; other site 278197001471 ABC transporter signature motif; other site 278197001472 Walker B; other site 278197001473 D-loop; other site 278197001474 H-loop/switch region; other site 278197001475 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 278197001476 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 278197001477 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 278197001478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197001479 catalytic residue [active] 278197001480 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 278197001481 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 278197001482 trimerization site [polypeptide binding]; other site 278197001483 active site 278197001484 FeS assembly protein SufB; Region: sufB; TIGR01980 278197001485 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 278197001486 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 278197001487 Helix-turn-helix domains; Region: HTH; cl00088 278197001488 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 278197001489 Spore germination protein; Region: Spore_permease; cl15802 278197001490 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 278197001491 substrate binding site [chemical binding]; other site 278197001492 THF binding site; other site 278197001493 zinc-binding site [ion binding]; other site 278197001494 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 278197001495 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 278197001496 catalytic residues [active] 278197001497 catalytic nucleophile [active] 278197001498 Presynaptic Site I dimer interface [polypeptide binding]; other site 278197001499 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 278197001500 Synaptic Flat tetramer interface [polypeptide binding]; other site 278197001501 Synaptic Site I dimer interface [polypeptide binding]; other site 278197001502 DNA binding site [nucleotide binding] 278197001503 Helix-turn-helix domains; Region: HTH; cl00088 278197001504 DNA-binding interface [nucleotide binding]; DNA binding site 278197001505 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 278197001506 Helix-turn-helix domains; Region: HTH; cl00088 278197001507 Integrase core domain; Region: rve; cl01316 278197001508 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278197001509 multicopper oxidase; Provisional; Region: PRK10965 278197001510 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278197001511 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278197001512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001513 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197001514 putative substrate translocation pore; other site 278197001515 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 278197001516 Cupin domain; Region: Cupin_2; cl09118 278197001517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197001518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197001519 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 278197001520 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197001521 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 278197001522 HPr interaction site; other site 278197001523 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197001524 active site 278197001525 phosphorylation site [posttranslational modification] 278197001526 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 278197001527 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 278197001528 PQ loop repeat; Region: PQ-loop; cl12056 278197001529 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197001530 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197001531 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 278197001532 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 278197001533 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 278197001534 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197001535 active site turn [active] 278197001536 phosphorylation site [posttranslational modification] 278197001537 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197001538 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 278197001539 HPr interaction site; other site 278197001540 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197001541 active site 278197001542 phosphorylation site [posttranslational modification] 278197001543 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 278197001544 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 278197001545 substrate binding [chemical binding]; other site 278197001546 active site 278197001547 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 278197001548 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197001549 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197001550 DNA binding site [nucleotide binding] 278197001551 domain linker motif; other site 278197001552 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 278197001553 dimerization interface [polypeptide binding]; other site 278197001554 ligand binding site [chemical binding]; other site 278197001555 sodium binding site [ion binding]; other site 278197001556 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 278197001557 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 278197001558 Ca binding site [ion binding]; other site 278197001559 active site 278197001560 catalytic site [active] 278197001561 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 278197001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001563 Helix-turn-helix domains; Region: HTH; cl00088 278197001564 DDE domain; Region: DDE_Tnp_IS240; pfam13610 278197001565 Integrase core domain; Region: rve; cl01316 278197001566 Integrase core domain; Region: rve_3; cl15866 278197001567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197001568 non-specific DNA binding site [nucleotide binding]; other site 278197001569 salt bridge; other site 278197001570 sequence-specific DNA binding site [nucleotide binding]; other site 278197001571 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 278197001572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197001573 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197001574 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 278197001575 putative active site [active] 278197001576 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) [Translation, ribosomal structure and biogenesis]; Region: GatE; COG2511 278197001577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 278197001578 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 278197001579 cofactor binding site; other site 278197001580 DNA binding site [nucleotide binding] 278197001581 substrate interaction site [chemical binding]; other site 278197001582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 278197001583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197001584 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 278197001585 PLD-like domain; Region: PLDc_2; pfam13091 278197001586 putative active site [active] 278197001587 catalytic site [active] 278197001588 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 278197001589 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001590 ATP binding site [chemical binding]; other site 278197001591 putative Mg++ binding site [ion binding]; other site 278197001592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001593 nucleotide binding region [chemical binding]; other site 278197001594 ATP-binding site [chemical binding]; other site 278197001595 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 278197001596 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001597 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278197001598 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 278197001599 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278197001600 Int/Topo IB signature motif; other site 278197001601 LicD family; Region: LicD; cl01378 278197001602 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 278197001603 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 278197001604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001605 NAD(P) binding site [chemical binding]; other site 278197001606 active site 278197001607 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 278197001608 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197001609 DNA binding residues [nucleotide binding] 278197001610 putative dimer interface [polypeptide binding]; other site 278197001611 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 278197001612 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 278197001613 putative dimer interface [polypeptide binding]; other site 278197001614 putative anticodon binding site; other site 278197001615 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 278197001616 homodimer interface [polypeptide binding]; other site 278197001617 motif 1; other site 278197001618 motif 2; other site 278197001619 active site 278197001620 motif 3; other site 278197001621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197001622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001623 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197001624 Coenzyme A binding pocket [chemical binding]; other site 278197001625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197001626 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197001627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197001628 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 278197001629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278197001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001631 putative substrate translocation pore; other site 278197001632 MarC family integral membrane protein; Region: MarC; cl00919 278197001633 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 278197001634 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 278197001635 CsbD-like; Region: CsbD; cl15799 278197001636 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 278197001637 substrate binding site [chemical binding]; other site 278197001638 multimerization interface [polypeptide binding]; other site 278197001639 ATP binding site [chemical binding]; other site 278197001640 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 278197001641 dimer interface [polypeptide binding]; other site 278197001642 substrate binding site [chemical binding]; other site 278197001643 ATP binding site [chemical binding]; other site 278197001644 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 278197001645 thiamine phosphate binding site [chemical binding]; other site 278197001646 active site 278197001647 pyrophosphate binding site [ion binding]; other site 278197001648 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 278197001649 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 278197001650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197001651 ATP binding site [chemical binding]; other site 278197001652 putative Mg++ binding site [ion binding]; other site 278197001653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001654 nucleotide binding region [chemical binding]; other site 278197001655 ATP-binding site [chemical binding]; other site 278197001656 RQC domain; Region: RQC; cl09632 278197001657 HRDC domain; Region: HRDC; cl02578 278197001658 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 278197001659 active site 278197001660 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197001661 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 278197001662 Chain length determinant protein; Region: Wzz; cl15801 278197001663 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 278197001664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001665 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 278197001666 Bacterial sugar transferase; Region: Bac_transf; cl00939 278197001667 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 278197001668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197001669 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 278197001670 putative ADP-binding pocket [chemical binding]; other site 278197001671 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 278197001672 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 278197001673 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278197001674 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 278197001675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001676 UDP-galactopyranose mutase; Region: GLF; pfam03275 278197001677 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 278197001678 MatE; Region: MatE; cl10513 278197001679 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 278197001680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 278197001681 active site 278197001682 OpgC protein; Region: OpgC_C; cl00792 278197001683 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278197001684 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 278197001685 active site 278197001686 P-loop; other site 278197001687 phosphorylation site [posttranslational modification] 278197001688 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197001689 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197001690 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 278197001691 active site 278197001692 methionine cluster; other site 278197001693 phosphorylation site [posttranslational modification] 278197001694 metal binding site [ion binding]; metal-binding site 278197001695 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197001696 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 278197001697 PRD domain; Region: PRD; cl15445 278197001698 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278197001699 active site 278197001700 phosphorylation site [posttranslational modification] 278197001701 VanZ like family; Region: VanZ; cl01971 278197001702 L-type amino acid transporter; Region: 2A0308; TIGR00911 278197001703 Predicted transcriptional regulator [Transcription]; Region: COG2378 278197001704 Helix-turn-helix domains; Region: HTH; cl00088 278197001705 WYL domain; Region: WYL; cl14852 278197001706 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197001707 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 278197001708 active site 278197001709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278197001710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001712 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 278197001713 ATP binding site [chemical binding]; other site 278197001714 putative Mg++ binding site [ion binding]; other site 278197001715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001716 nucleotide binding region [chemical binding]; other site 278197001717 ATP-binding site [chemical binding]; other site 278197001718 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278197001719 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 278197001720 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 278197001721 active site 278197001722 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 278197001723 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 278197001724 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 278197001725 active site 278197001726 homodimer interface [polypeptide binding]; other site 278197001727 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197001728 RecX family; Region: RecX; cl00936 278197001729 Protein of unknown function (DUF402); Region: DUF402; cl00979 278197001730 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278197001731 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 278197001732 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197001733 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 278197001734 active site 278197001735 nucleotide binding site [chemical binding]; other site 278197001736 HIGH motif; other site 278197001737 KMSKS motif; other site 278197001738 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 278197001739 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 278197001740 G1 box; other site 278197001741 putative GEF interaction site [polypeptide binding]; other site 278197001742 GTP/Mg2+ binding site [chemical binding]; other site 278197001743 Switch I region; other site 278197001744 G2 box; other site 278197001745 G3 box; other site 278197001746 Switch II region; other site 278197001747 G4 box; other site 278197001748 G5 box; other site 278197001749 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 278197001750 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 278197001751 Sulfatase; Region: Sulfatase; cl10460 278197001752 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278197001753 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 278197001754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197001755 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278197001756 Walker A motif; other site 278197001757 ATP binding site [chemical binding]; other site 278197001758 Walker B motif; other site 278197001759 arginine finger; other site 278197001760 excinuclease ABC, B subunit; Region: uvrb; TIGR00631 278197001761 UvrB/uvrC motif; Region: UVR; pfam02151 278197001762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197001763 Walker A motif; other site 278197001764 ATP binding site [chemical binding]; other site 278197001765 Walker B motif; other site 278197001766 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278197001767 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 278197001768 dimerization domain swap beta strand [polypeptide binding]; other site 278197001769 regulatory protein interface [polypeptide binding]; other site 278197001770 active site 278197001771 regulatory phosphorylation site [posttranslational modification]; other site 278197001772 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 278197001773 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 278197001774 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 278197001775 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278197001776 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278197001777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197001778 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 278197001779 putative ADP-binding pocket [chemical binding]; other site 278197001780 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278197001781 Predicted integral membrane protein [Function unknown]; Region: COG0392 278197001782 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 278197001783 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 278197001784 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 278197001785 PYR/PP interface [polypeptide binding]; other site 278197001786 dimer interface [polypeptide binding]; other site 278197001787 tetramer interface [polypeptide binding]; other site 278197001788 TPP binding site [chemical binding]; other site 278197001789 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278197001790 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 278197001791 TPP-binding site [chemical binding]; other site 278197001792 S-adenosylmethionine synthetase; Validated; Region: PRK05250 278197001793 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 278197001794 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 278197001795 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 278197001796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197001797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001798 putative substrate translocation pore; other site 278197001799 Methyltransferase domain; Region: Methyltransf_31; pfam13847 278197001800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001801 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 278197001802 active site 278197001803 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 278197001804 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 278197001805 HIGH motif; other site 278197001806 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278197001807 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 278197001808 active site 278197001809 KMSKS motif; other site 278197001810 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 278197001811 tRNA binding surface [nucleotide binding]; other site 278197001812 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 278197001813 MatE; Region: MatE; cl10513 278197001814 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 278197001815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197001816 RNA binding surface [nucleotide binding]; other site 278197001817 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 278197001818 active site 278197001819 uracil binding [chemical binding]; other site 278197001820 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 278197001821 putative substrate binding site [chemical binding]; other site 278197001822 putative ATP binding site [chemical binding]; other site 278197001823 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197001824 Ligand Binding Site [chemical binding]; other site 278197001825 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 278197001826 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 278197001827 Substrate-binding site [chemical binding]; other site 278197001828 Substrate specificity [chemical binding]; other site 278197001829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001830 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197001831 active site 278197001832 motif I; other site 278197001833 motif II; other site 278197001834 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197001835 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 278197001836 active site 278197001837 zinc binding site [ion binding]; other site 278197001838 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 278197001839 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 278197001840 active site 278197001841 dimer interface [polypeptide binding]; other site 278197001842 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 278197001843 Ligand Binding Site [chemical binding]; other site 278197001844 Molecular Tunnel; other site 278197001845 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 278197001846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278197001847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197001848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197001849 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 278197001850 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197001851 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 278197001852 aspartate racemase; Region: asp_race; TIGR00035 278197001853 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 278197001854 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 278197001855 inner membrane transporter YjeM; Provisional; Region: PRK15238 278197001856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001857 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197001858 active site 278197001859 motif I; other site 278197001860 motif II; other site 278197001861 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197001862 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 278197001863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197001864 active site 278197001865 catalytic tetrad [active] 278197001866 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 278197001867 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 278197001868 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 278197001869 active site 278197001870 HIGH motif; other site 278197001871 KMSK motif region; other site 278197001872 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 278197001873 tRNA binding surface [nucleotide binding]; other site 278197001874 anticodon binding site; other site 278197001875 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278197001876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278197001877 ligand binding site [chemical binding]; other site 278197001878 flexible hinge region; other site 278197001879 Arginine repressor [Transcription]; Region: ArgR; COG1438 278197001880 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 278197001881 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 278197001882 Transglycosylase; Region: Transgly; cl07896 278197001883 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 278197001884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197001885 Protein of unknown function (DUF964); Region: DUF964; cl01483 278197001886 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 278197001887 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 278197001888 active site 278197001889 metal binding site [ion binding]; metal-binding site 278197001890 DNA binding site [nucleotide binding] 278197001891 Uncharacterized conserved protein [Function unknown]; Region: COG4717 278197001892 Uncharacterized conserved protein [Function unknown]; Region: COG4717 278197001893 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 278197001894 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 278197001895 generic binding surface II; other site 278197001896 generic binding surface I; other site 278197001897 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 278197001898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197001899 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 278197001900 PPIC-type PPIASE domain; Region: Rotamase; cl08278 278197001901 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 278197001902 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 278197001903 HIT family signature motif; other site 278197001904 catalytic residue [active] 278197001905 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 278197001906 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 278197001907 Walker A/P-loop; other site 278197001908 ATP binding site [chemical binding]; other site 278197001909 Q-loop/lid; other site 278197001910 ABC transporter signature motif; other site 278197001911 Walker B; other site 278197001912 D-loop; other site 278197001913 H-loop/switch region; other site 278197001914 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 278197001915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197001916 S-adenosylmethionine binding site [chemical binding]; other site 278197001917 Predicted small secreted protein [Function unknown]; Region: COG5584 278197001918 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 278197001919 putative tRNA-binding site [nucleotide binding]; other site 278197001920 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 278197001921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197001922 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 278197001923 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 278197001924 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278197001925 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197001926 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197001927 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 278197001928 DNA polymerase I; Provisional; Region: PRK05755 278197001929 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 278197001930 active site 278197001931 metal binding site 1 [ion binding]; metal-binding site 278197001932 putative 5' ssDNA interaction site; other site 278197001933 metal binding site 3; metal-binding site 278197001934 metal binding site 2 [ion binding]; metal-binding site 278197001935 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 278197001936 putative DNA binding site [nucleotide binding]; other site 278197001937 putative metal binding site [ion binding]; other site 278197001938 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 278197001939 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 278197001940 active site 278197001941 DNA binding site [nucleotide binding] 278197001942 catalytic site [active] 278197001943 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 278197001944 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 278197001945 DNA binding site [nucleotide binding] 278197001946 catalytic residue [active] 278197001947 H2TH interface [polypeptide binding]; other site 278197001948 putative catalytic residues [active] 278197001949 turnover-facilitating residue; other site 278197001950 intercalation triad [nucleotide binding]; other site 278197001951 8OG recognition residue [nucleotide binding]; other site 278197001952 putative reading head residues; other site 278197001953 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 278197001954 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278197001955 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 278197001956 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 278197001957 CoA-binding site [chemical binding]; other site 278197001958 ATP-binding [chemical binding]; other site 278197001959 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 278197001960 ATP cone domain; Region: ATP-cone; pfam03477 278197001961 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 278197001962 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 278197001963 primosomal protein DnaI; Reviewed; Region: PRK08939 278197001964 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 278197001965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197001966 Walker A motif; other site 278197001967 ATP binding site [chemical binding]; other site 278197001968 Walker B motif; other site 278197001969 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 278197001970 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 278197001971 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 278197001972 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 278197001973 active site 278197001974 dimer interface [polypeptide binding]; other site 278197001975 motif 1; other site 278197001976 motif 2; other site 278197001977 motif 3; other site 278197001978 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 278197001979 anticodon binding site; other site 278197001980 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 278197001981 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 278197001982 GAF domain; Region: GAF; cl15785 278197001983 Histidine kinase; Region: His_kinase; pfam06580 278197001984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197001985 ATP binding site [chemical binding]; other site 278197001986 Mg2+ binding site [ion binding]; other site 278197001987 G-X-G motif; other site 278197001988 two-component response regulator; Provisional; Region: PRK14084 278197001989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197001990 active site 278197001991 phosphorylation site [posttranslational modification] 278197001992 intermolecular recognition site; other site 278197001993 dimerization interface [polypeptide binding]; other site 278197001994 LytTr DNA-binding domain; Region: LytTR; cl04498 278197001995 LrgA family; Region: LrgA; cl00608 278197001996 LrgB-like family; Region: LrgB; cl00596 278197001997 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 278197001998 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 278197001999 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 278197002000 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 278197002001 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 278197002002 23S rRNA binding site [nucleotide binding]; other site 278197002003 L21 binding site [polypeptide binding]; other site 278197002004 L13 binding site [polypeptide binding]; other site 278197002005 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278197002006 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 278197002007 putative NAD(P) binding site [chemical binding]; other site 278197002008 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 278197002009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197002010 active site 278197002011 motif I; other site 278197002012 motif II; other site 278197002013 GTPase YqeH; Provisional; Region: PRK13796 278197002014 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 278197002015 GTP/Mg2+ binding site [chemical binding]; other site 278197002016 G4 box; other site 278197002017 G5 box; other site 278197002018 G1 box; other site 278197002019 Switch I region; other site 278197002020 G2 box; other site 278197002021 G3 box; other site 278197002022 Switch II region; other site 278197002023 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 278197002024 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 278197002025 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 278197002026 active site 278197002027 (T/H)XGH motif; other site 278197002028 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 278197002029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197002030 Zn2+ binding site [ion binding]; other site 278197002031 Mg2+ binding site [ion binding]; other site 278197002032 Oligomerisation domain; Region: Oligomerisation; cl00519 278197002033 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278197002034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002035 S-adenosylmethionine binding site [chemical binding]; other site 278197002036 hypothetical protein; Provisional; Region: PRK13670 278197002037 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197002038 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 278197002039 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 278197002040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197002041 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 278197002042 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 278197002043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197002044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197002045 active site 278197002046 phosphorylation site [posttranslational modification] 278197002047 intermolecular recognition site; other site 278197002048 dimerization interface [polypeptide binding]; other site 278197002049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197002050 DNA binding site [nucleotide binding] 278197002051 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 278197002052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278197002053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197002054 dimer interface [polypeptide binding]; other site 278197002055 phosphorylation site [posttranslational modification] 278197002056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197002057 ATP binding site [chemical binding]; other site 278197002058 Mg2+ binding site [ion binding]; other site 278197002059 G-X-G motif; other site 278197002060 OxaA-like protein precursor; Provisional; Region: PRK02463 278197002061 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 278197002062 Acylphosphatase; Region: Acylphosphatase; cl00551 278197002063 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 278197002064 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 278197002065 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278197002066 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 278197002067 Helix-turn-helix domains; Region: HTH; cl00088 278197002068 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 278197002069 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 278197002070 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 278197002071 dimer interface [polypeptide binding]; other site 278197002072 motif 1; other site 278197002073 active site 278197002074 motif 2; other site 278197002075 motif 3; other site 278197002076 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 278197002077 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 278197002078 putative tRNA-binding site [nucleotide binding]; other site 278197002079 B3/4 domain; Region: B3_4; cl11458 278197002080 tRNA synthetase B5 domain; Region: B5; cl08394 278197002081 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 278197002082 dimer interface [polypeptide binding]; other site 278197002083 motif 1; other site 278197002084 motif 3; other site 278197002085 motif 2; other site 278197002086 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 278197002087 YceG-like family; Region: YceG; pfam02618 278197002088 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 278197002089 dimerization interface [polypeptide binding]; other site 278197002090 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 278197002091 Sugar specificity; other site 278197002092 Pyrimidine base specificity; other site 278197002093 ATP-binding site [chemical binding]; other site 278197002094 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 278197002095 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 278197002096 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 278197002097 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 278197002098 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 278197002099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197002100 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 278197002101 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 278197002102 Rhomboid family; Region: Rhomboid; cl11446 278197002103 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 278197002104 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 278197002105 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197002106 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278197002107 active site residue [active] 278197002108 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 278197002109 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 278197002110 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 278197002111 active site 278197002112 catalytic site [active] 278197002113 metal binding site [ion binding]; metal-binding site 278197002114 dimer interface [polypeptide binding]; other site 278197002115 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 278197002116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197002117 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278197002118 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 278197002119 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 278197002120 DNA binding residues [nucleotide binding] 278197002121 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197002122 putative dimer interface [polypeptide binding]; other site 278197002123 glutamine synthetase, type I; Region: GlnA; TIGR00653 278197002124 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 278197002125 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278197002126 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 278197002127 dUTPase; Region: dUTPase_2; pfam08761 278197002128 integrase; Provisional; Region: int; PHA02601 278197002129 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278197002130 Int/Topo IB signature motif; other site 278197002131 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197002132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197002133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197002134 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 278197002135 ORF6C domain; Region: ORF6C; pfam10552 278197002136 Domain of unknown function (DUF771); Region: DUF771; cl09962 278197002137 ERF superfamily; Region: ERF; pfam04404 278197002138 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278197002139 dimer interface [polypeptide binding]; other site 278197002140 ssDNA binding site [nucleotide binding]; other site 278197002141 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197002142 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 278197002143 replicative DNA helicase; Region: DnaB; TIGR00665 278197002144 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 278197002145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197002146 Walker A motif; other site 278197002147 ATP binding site [chemical binding]; other site 278197002148 Walker B motif; other site 278197002149 Endodeoxyribonuclease RusA; Region: RusA; cl01885 278197002150 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 278197002151 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 278197002152 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 278197002153 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 278197002154 YfbU domain; Region: YfbU; cl01137 278197002155 Helix-turn-helix domains; Region: HTH; cl00088 278197002156 Phage terminase large subunit; Region: Terminase_3; cl12054 278197002157 Terminase-like family; Region: Terminase_6; pfam03237 278197002158 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 278197002159 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 278197002160 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 278197002161 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 278197002162 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 278197002163 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 278197002164 Phage major tail protein 2; Region: Phage_tail_2; cl11463 278197002165 Phage protein; Region: DUF3647; cl10335 278197002166 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 278197002167 Phage-related protein [Function unknown]; Region: COG5412 278197002168 Phage tail protein; Region: Sipho_tail; pfam05709 278197002169 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278197002170 Peptidase family M23; Region: Peptidase_M23; pfam01551 278197002171 NlpC/P60 family; Region: NLPC_P60; cl11438 278197002172 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 278197002173 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 278197002174 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278197002175 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 278197002176 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 278197002177 Holin family; Region: Phage_holin_4; cl01989 278197002178 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 278197002179 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 278197002180 active site 278197002181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197002182 Helix-turn-helix domains; Region: HTH; cl00088 278197002183 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 278197002184 Protein of unknown function (DUF464); Region: DUF464; cl01080 278197002185 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 278197002186 elongation factor P; Validated; Region: PRK00529 278197002187 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 278197002188 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 278197002189 RNA binding site [nucleotide binding]; other site 278197002190 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 278197002191 RNA binding site [nucleotide binding]; other site 278197002192 Asp23 family; Region: Asp23; cl00574 278197002193 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 278197002194 putative RNA binding site [nucleotide binding]; other site 278197002195 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 278197002196 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 278197002197 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 278197002198 homodimer interface [polypeptide binding]; other site 278197002199 NADP binding site [chemical binding]; other site 278197002200 substrate binding site [chemical binding]; other site 278197002201 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 278197002202 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 278197002203 generic binding surface II; other site 278197002204 generic binding surface I; other site 278197002205 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 278197002206 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 278197002207 substrate binding pocket [chemical binding]; other site 278197002208 chain length determination region; other site 278197002209 substrate-Mg2+ binding site; other site 278197002210 catalytic residues [active] 278197002211 aspartate-rich region 1; other site 278197002212 active site lid residues [active] 278197002213 aspartate-rich region 2; other site 278197002214 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 278197002215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197002216 RNA binding surface [nucleotide binding]; other site 278197002217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 278197002218 Arginine repressor [Transcription]; Region: ArgR; COG1438 278197002219 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 278197002220 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 278197002221 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 278197002222 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 278197002223 Walker A/P-loop; other site 278197002224 ATP binding site [chemical binding]; other site 278197002225 Q-loop/lid; other site 278197002226 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 278197002227 ABC transporter signature motif; other site 278197002228 Walker B; other site 278197002229 D-loop; other site 278197002230 H-loop/switch region; other site 278197002231 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 278197002232 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 278197002233 catalytic site [active] 278197002234 G-X2-G-X-G-K; other site 278197002235 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 278197002236 Flavoprotein; Region: Flavoprotein; cl08021 278197002237 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 278197002238 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 278197002239 primosome assembly protein PriA; Validated; Region: PRK05580 278197002240 primosome assembly protein PriA; Validated; Region: PRK05580 278197002241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002242 ATP binding site [chemical binding]; other site 278197002243 putative Mg++ binding site [ion binding]; other site 278197002244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197002245 nucleotide binding region [chemical binding]; other site 278197002246 ATP-binding site [chemical binding]; other site 278197002247 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 278197002248 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 278197002249 putative active site [active] 278197002250 substrate binding site [chemical binding]; other site 278197002251 putative cosubstrate binding site; other site 278197002252 catalytic site [active] 278197002253 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 278197002254 substrate binding site [chemical binding]; other site 278197002255 16S rRNA methyltransferase B; Provisional; Region: PRK14902 278197002256 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 278197002257 putative RNA binding site [nucleotide binding]; other site 278197002258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002259 S-adenosylmethionine binding site [chemical binding]; other site 278197002260 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 278197002261 active site 278197002262 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278197002263 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278197002264 active site 278197002265 ATP binding site [chemical binding]; other site 278197002266 substrate binding site [chemical binding]; other site 278197002267 activation loop (A-loop); other site 278197002268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278197002269 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278197002270 GTPase RsgA; Reviewed; Region: PRK00098 278197002271 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 278197002272 RNA binding site [nucleotide binding]; other site 278197002273 homodimer interface [polypeptide binding]; other site 278197002274 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 278197002275 GTPase/Zn-binding domain interface [polypeptide binding]; other site 278197002276 GTP/Mg2+ binding site [chemical binding]; other site 278197002277 G4 box; other site 278197002278 G5 box; other site 278197002279 G1 box; other site 278197002280 Switch I region; other site 278197002281 G2 box; other site 278197002282 G3 box; other site 278197002283 Switch II region; other site 278197002284 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 278197002285 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 278197002286 substrate binding site [chemical binding]; other site 278197002287 hexamer interface [polypeptide binding]; other site 278197002288 metal binding site [ion binding]; metal-binding site 278197002289 Thiamine pyrophosphokinase; Region: TPK; cd07995 278197002290 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 278197002291 active site 278197002292 dimerization interface [polypeptide binding]; other site 278197002293 thiamine binding site [chemical binding]; other site 278197002294 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 278197002295 Asp23 family; Region: Asp23; cl00574 278197002296 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 278197002297 DAK2 domain; Region: Dak2; cl03685 278197002298 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278197002299 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 278197002300 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 278197002301 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 278197002302 generic binding surface II; other site 278197002303 ssDNA binding site; other site 278197002304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002305 ATP binding site [chemical binding]; other site 278197002306 putative Mg++ binding site [ion binding]; other site 278197002307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197002308 nucleotide binding region [chemical binding]; other site 278197002309 ATP-binding site [chemical binding]; other site 278197002310 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 278197002311 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278197002312 ribonuclease III; Reviewed; Region: rnc; PRK00102 278197002313 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 278197002314 dimerization interface [polypeptide binding]; other site 278197002315 active site 278197002316 metal binding site [ion binding]; metal-binding site 278197002317 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 278197002318 dsRNA binding site [nucleotide binding]; other site 278197002319 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 278197002320 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 278197002321 Walker A/P-loop; other site 278197002322 ATP binding site [chemical binding]; other site 278197002323 Q-loop/lid; other site 278197002324 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 278197002325 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 278197002326 ABC transporter signature motif; other site 278197002327 Walker B; other site 278197002328 D-loop; other site 278197002329 H-loop/switch region; other site 278197002330 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 278197002331 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 278197002332 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 278197002333 P loop; other site 278197002334 GTP binding site [chemical binding]; other site 278197002335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197002336 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 278197002337 signal recognition particle protein; Provisional; Region: PRK10867 278197002338 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 278197002339 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 278197002340 GTP binding site [chemical binding]; other site 278197002341 Signal peptide binding domain; Region: SRP_SPB; pfam02978 278197002342 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 278197002343 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 278197002344 RimM N-terminal domain; Region: RimM; pfam01782 278197002345 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 278197002346 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 278197002347 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 278197002348 DsrE/DsrF-like family; Region: DrsE; cl00672 278197002349 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 278197002350 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 278197002351 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 278197002352 dimer interface [polypeptide binding]; other site 278197002353 active site 278197002354 CoA binding pocket [chemical binding]; other site 278197002355 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278197002356 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278197002357 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278197002358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197002359 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278197002360 NAD(P) binding site [chemical binding]; other site 278197002361 active site 278197002362 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 278197002363 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 278197002364 dimer interface [polypeptide binding]; other site 278197002365 active site 278197002366 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 278197002367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278197002368 carboxyltransferase (CT) interaction site; other site 278197002369 biotinylation site [posttranslational modification]; other site 278197002370 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 278197002371 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 278197002372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197002373 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197002374 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 278197002375 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 278197002376 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278197002377 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278197002378 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 278197002379 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 278197002380 NAD binding site [chemical binding]; other site 278197002381 homotetramer interface [polypeptide binding]; other site 278197002382 homodimer interface [polypeptide binding]; other site 278197002383 substrate binding site [chemical binding]; other site 278197002384 active site 278197002385 putative transport protein YifK; Provisional; Region: PRK10746 278197002386 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 278197002387 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 278197002388 dimer interface [polypeptide binding]; other site 278197002389 active site 278197002390 Helix-turn-helix domains; Region: HTH; cl00088 278197002391 LexA repressor; Validated; Region: PRK00215 278197002392 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 278197002393 Catalytic site [active] 278197002394 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 278197002395 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 278197002396 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278197002397 putative acyl-acceptor binding pocket; other site 278197002398 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 278197002399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002400 S-adenosylmethionine binding site [chemical binding]; other site 278197002401 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 278197002402 GIY-YIG motif/motif A; other site 278197002403 putative active site [active] 278197002404 putative metal binding site [ion binding]; other site 278197002405 D-lactate dehydrogenase; Validated; Region: PRK08605 278197002406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197002407 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 278197002408 rRNA interaction site [nucleotide binding]; other site 278197002409 S8 interaction site; other site 278197002410 putative laminin-1 binding site; other site 278197002411 elongation factor Ts; Provisional; Region: tsf; PRK09377 278197002412 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 278197002413 Elongation factor TS; Region: EF_TS; pfam00889 278197002414 Elongation factor TS; Region: EF_TS; pfam00889 278197002415 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 278197002416 putative nucleotide binding site [chemical binding]; other site 278197002417 uridine monophosphate binding site [chemical binding]; other site 278197002418 homohexameric interface [polypeptide binding]; other site 278197002419 ribosome recycling factor; Reviewed; Region: frr; PRK00083 278197002420 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 278197002421 hinge region; other site 278197002422 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 278197002423 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 278197002424 catalytic residue [active] 278197002425 putative FPP diphosphate binding site; other site 278197002426 putative FPP binding hydrophobic cleft; other site 278197002427 dimer interface [polypeptide binding]; other site 278197002428 putative IPP diphosphate binding site; other site 278197002429 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 278197002430 RIP metalloprotease RseP; Region: TIGR00054 278197002431 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 278197002432 active site 278197002433 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 278197002434 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 278197002435 protein binding site [polypeptide binding]; other site 278197002436 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 278197002437 putative substrate binding region [chemical binding]; other site 278197002438 prolyl-tRNA synthetase; Provisional; Region: PRK09194 278197002439 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 278197002440 dimer interface [polypeptide binding]; other site 278197002441 motif 1; other site 278197002442 active site 278197002443 motif 2; other site 278197002444 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 278197002445 putative deacylase active site [active] 278197002446 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278197002447 active site 278197002448 motif 3; other site 278197002449 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 278197002450 anticodon binding site; other site 278197002451 DNA polymerase III PolC; Validated; Region: polC; PRK00448 278197002452 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 278197002453 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 278197002454 generic binding surface II; other site 278197002455 generic binding surface I; other site 278197002456 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 278197002457 active site 278197002458 catalytic site [active] 278197002459 substrate binding site [chemical binding]; other site 278197002460 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 278197002461 ribosome maturation protein RimP; Reviewed; Region: PRK00092 278197002462 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 278197002463 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 278197002464 Sm1 motif; other site 278197002465 predicted subunit interaction site [polypeptide binding]; other site 278197002466 RNA binding pocket [nucleotide binding]; other site 278197002467 Sm2 motif; other site 278197002468 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 278197002469 NusA N-terminal domain; Region: NusA_N; pfam08529 278197002470 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 278197002471 RNA binding site [nucleotide binding]; other site 278197002472 homodimer interface [polypeptide binding]; other site 278197002473 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278197002474 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 278197002475 G-X-X-G motif; other site 278197002476 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 278197002477 putative RNA binding cleft [nucleotide binding]; other site 278197002478 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 278197002479 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278197002480 translation initiation factor IF-2; Region: IF-2; TIGR00487 278197002481 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278197002482 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 278197002483 G1 box; other site 278197002484 putative GEF interaction site [polypeptide binding]; other site 278197002485 GTP/Mg2+ binding site [chemical binding]; other site 278197002486 Switch I region; other site 278197002487 G2 box; other site 278197002488 G3 box; other site 278197002489 Switch II region; other site 278197002490 G4 box; other site 278197002491 G5 box; other site 278197002492 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 278197002493 Translation-initiation factor 2; Region: IF-2; pfam11987 278197002494 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 278197002495 Ribosome-binding factor A; Region: RBFA; cl00542 278197002496 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 278197002497 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 278197002498 RNA binding site [nucleotide binding]; other site 278197002499 active site 278197002500 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 278197002501 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 278197002502 active site 278197002503 Riboflavin kinase; Region: Flavokinase; cl03312 278197002504 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 278197002505 Helix-turn-helix domains; Region: HTH; cl00088 278197002506 HrcA protein C terminal domain; Region: HrcA; pfam01628 278197002507 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 278197002508 dimer interface [polypeptide binding]; other site 278197002509 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 278197002510 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 278197002511 chaperone protein DnaJ; Provisional; Region: PRK14276 278197002512 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 278197002513 HSP70 interaction site [polypeptide binding]; other site 278197002514 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 278197002515 substrate binding site [polypeptide binding]; other site 278197002516 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 278197002517 Zn binding sites [ion binding]; other site 278197002518 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 278197002519 substrate binding site [polypeptide binding]; other site 278197002520 dimer interface [polypeptide binding]; other site 278197002521 Domain of unknown function (DUF378); Region: DUF378; cl00943 278197002522 TspO/MBR family; Region: TspO_MBR; cl01379 278197002523 QueT transporter; Region: QueT; cl01932 278197002524 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 278197002525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278197002526 classical (c) SDRs; Region: SDR_c; cd05233 278197002527 NAD(P) binding site [chemical binding]; other site 278197002528 active site 278197002529 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 278197002530 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 278197002531 dimanganese center [ion binding]; other site 278197002532 GTP-binding protein LepA; Provisional; Region: PRK05433 278197002533 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 278197002534 G1 box; other site 278197002535 putative GEF interaction site [polypeptide binding]; other site 278197002536 GTP/Mg2+ binding site [chemical binding]; other site 278197002537 Switch I region; other site 278197002538 G2 box; other site 278197002539 G3 box; other site 278197002540 Switch II region; other site 278197002541 G4 box; other site 278197002542 G5 box; other site 278197002543 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 278197002544 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 278197002545 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 278197002546 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278197002547 transmembrane helices; other site 278197002548 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197002549 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 278197002550 active site 1 [active] 278197002551 dimer interface [polypeptide binding]; other site 278197002552 hexamer interface [polypeptide binding]; other site 278197002553 active site 2 [active] 278197002554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197002555 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197002556 active site 278197002557 motif I; other site 278197002558 motif II; other site 278197002559 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 278197002560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002561 S-adenosylmethionine binding site [chemical binding]; other site 278197002562 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 278197002563 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 278197002564 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 278197002565 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278197002566 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278197002567 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278197002568 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 278197002569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197002570 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197002571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278197002572 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197002573 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 278197002574 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 278197002575 teramer interface [polypeptide binding]; other site 278197002576 active site 278197002577 FMN binding site [chemical binding]; other site 278197002578 catalytic residues [active] 278197002579 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 278197002580 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 278197002581 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 278197002582 homotetramer interface [polypeptide binding]; other site 278197002583 FMN binding site [chemical binding]; other site 278197002584 homodimer contacts [polypeptide binding]; other site 278197002585 putative active site [active] 278197002586 putative substrate binding site [chemical binding]; other site 278197002587 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 278197002588 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197002589 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 278197002590 mevalonate kinase; Region: mevalon_kin; TIGR00549 278197002591 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197002592 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197002593 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 278197002594 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 278197002595 active site 278197002596 catalytic site [active] 278197002597 substrate binding site [chemical binding]; other site 278197002598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002599 ATP binding site [chemical binding]; other site 278197002600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197002601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 278197002602 Helix-turn-helix domains; Region: HTH; cl00088 278197002603 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 278197002604 Transglycosylase; Region: Transgly; cl07896 278197002605 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 278197002606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197002607 Recombination protein U; Region: RecU; cl01314 278197002608 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 278197002609 cell division protein GpsB; Provisional; Region: PRK14127 278197002610 DivIVA domain; Region: DivI1A_domain; TIGR03544 278197002611 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 278197002612 THUMP domain; Region: THUMP; cl12076 278197002613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197002614 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 278197002615 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 278197002616 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 278197002617 Potassium binding sites [ion binding]; other site 278197002618 Cesium cation binding sites [ion binding]; other site 278197002619 lipoprotein signal peptidase; Provisional; Region: PRK14787 278197002620 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 278197002621 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 278197002622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197002623 RNA binding surface [nucleotide binding]; other site 278197002624 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 278197002625 active site 278197002626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197002627 active site 278197002628 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 278197002629 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 278197002630 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 278197002631 catalytic site [active] 278197002632 subunit interface [polypeptide binding]; other site 278197002633 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 278197002634 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197002635 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 278197002636 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 278197002637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197002638 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 278197002639 Domain of unknown function (DUF814); Region: DUF814; pfam05670 278197002640 Helix-turn-helix domains; Region: HTH; cl00088 278197002641 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197002642 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278197002643 CrcB-like protein; Region: CRCB; cl09114 278197002644 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 278197002645 inner membrane transporter YjeM; Provisional; Region: PRK15238 278197002646 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 278197002647 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 278197002648 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 278197002649 Glycerate kinase family; Region: Gly_kinase; cl00841 278197002650 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 278197002651 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 278197002652 DHHA2 domain; Region: DHHA2; pfam02833 278197002653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197002654 Helix-turn-helix domains; Region: HTH; cl00088 278197002655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197002656 dimerization interface [polypeptide binding]; other site 278197002657 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 278197002658 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 278197002659 CAP-like domain; other site 278197002660 active site 278197002661 primary dimer interface [polypeptide binding]; other site 278197002662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197002663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197002664 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197002665 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 278197002666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197002667 ATP binding site [chemical binding]; other site 278197002668 Mg2+ binding site [ion binding]; other site 278197002669 G-X-G motif; other site 278197002670 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 278197002671 anchoring element; other site 278197002672 dimer interface [polypeptide binding]; other site 278197002673 ATP binding site [chemical binding]; other site 278197002674 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 278197002675 active site 278197002676 putative metal-binding site [ion binding]; other site 278197002677 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 278197002678 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 278197002679 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 278197002680 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 278197002681 active site 278197002682 catalytic residues [active] 278197002683 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 278197002684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002685 Walker A motif; other site 278197002686 ATP binding site [chemical binding]; other site 278197002687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197002688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278197002689 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 278197002690 active site 278197002691 HslU subunit interaction site [polypeptide binding]; other site 278197002692 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278197002693 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278197002694 active site 278197002695 DNA binding site [nucleotide binding] 278197002696 Int/Topo IB signature motif; other site 278197002697 DNA topoisomerase I; Validated; Region: PRK05582 278197002698 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 278197002699 active site 278197002700 interdomain interaction site; other site 278197002701 putative metal-binding site [ion binding]; other site 278197002702 nucleotide binding site [chemical binding]; other site 278197002703 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 278197002704 domain I; other site 278197002705 DNA binding groove [nucleotide binding] 278197002706 phosphate binding site [ion binding]; other site 278197002707 domain II; other site 278197002708 domain III; other site 278197002709 nucleotide binding site [chemical binding]; other site 278197002710 catalytic site [active] 278197002711 domain IV; other site 278197002712 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 278197002713 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 278197002714 beta-phosphoglucomutase; Region: bPGM; TIGR01990 278197002715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197002716 motif II; other site 278197002717 maltose phosphorylase; Provisional; Region: PRK13807 278197002718 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 278197002719 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 278197002720 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 278197002721 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 278197002722 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197002723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197002724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197002725 DNA binding site [nucleotide binding] 278197002726 domain linker motif; other site 278197002727 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 278197002728 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 278197002729 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 278197002730 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 278197002731 RNA/DNA hybrid binding site [nucleotide binding]; other site 278197002732 active site 278197002733 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 278197002734 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 278197002735 GTP/Mg2+ binding site [chemical binding]; other site 278197002736 G4 box; other site 278197002737 G5 box; other site 278197002738 G1 box; other site 278197002739 Switch I region; other site 278197002740 G2 box; other site 278197002741 G3 box; other site 278197002742 Switch II region; other site 278197002743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002744 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278197002745 Walker A motif; other site 278197002746 ATP binding site [chemical binding]; other site 278197002747 Walker B motif; other site 278197002748 arginine finger; other site 278197002749 MoxR-like ATPases [General function prediction only]; Region: COG0714 278197002750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002751 Walker A motif; other site 278197002752 ATP binding site [chemical binding]; other site 278197002753 Walker B motif; other site 278197002754 arginine finger; other site 278197002755 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278197002756 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 278197002757 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 278197002758 WxL domain surface cell wall-binding; Region: WxL; pfam13731 278197002759 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 278197002760 Haemolysin XhlA; Region: XhlA; pfam10779 278197002761 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 278197002762 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 278197002763 active site 278197002764 Bacterial SH3 domain; Region: SH3_3; cl02551 278197002765 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197002766 putative peptidoglycan binding site; other site 278197002767 Protein of unknown function (DUF724); Region: DUF724; pfam05266 278197002768 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 278197002769 Phage tail protein; Region: Sipho_tail; pfam05709 278197002770 Phage-related tail protein [Function unknown]; Region: COG5283 278197002771 adenylate kinase; Provisional; Region: PRK13808 278197002772 Phage-related protein [Function unknown]; Region: COG5412 278197002773 Peptidase family M23; Region: Peptidase_M23; pfam01551 278197002774 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 278197002775 N-acetyl-D-glucosamine binding site [chemical binding]; other site 278197002776 catalytic residue [active] 278197002777 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 278197002778 Phage major tail protein; Region: Phage_tail; pfam04630 278197002779 Protein of unknown function (DUF806); Region: DUF806; pfam05657 278197002780 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 278197002781 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 278197002782 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 278197002783 oligomerization interface [polypeptide binding]; other site 278197002784 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 278197002785 Phage capsid family; Region: Phage_capsid; pfam05065 278197002786 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 278197002787 oligomer interface [polypeptide binding]; other site 278197002788 active site residues [active] 278197002789 Phage portal protein; Region: Phage_portal; pfam04860 278197002790 Phage-related protein [Function unknown]; Region: COG4695; cl01923 278197002791 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 278197002792 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 278197002793 Phage Terminase; Region: Terminase_1; pfam03354 278197002794 Phage terminase, small subunit; Region: Terminase_4; cl01525 278197002795 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278197002796 active site 278197002797 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 278197002798 Endodeoxyribonuclease RusA; Region: RusA; cl01885 278197002799 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 278197002800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002801 Walker A motif; other site 278197002802 ATP binding site [chemical binding]; other site 278197002803 Walker B motif; other site 278197002804 arginine finger; other site 278197002805 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 278197002806 Protein of unknown function (DUF968); Region: DUF968; pfam06147 278197002807 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278197002808 dimer interface [polypeptide binding]; other site 278197002809 ssDNA binding site [nucleotide binding]; other site 278197002810 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197002811 ERF superfamily; Region: ERF; pfam04404 278197002812 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 278197002813 BRO family, N-terminal domain; Region: Bro-N; cl10591 278197002814 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 278197002815 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197002816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197002817 non-specific DNA binding site [nucleotide binding]; other site 278197002818 salt bridge; other site 278197002819 sequence-specific DNA binding site [nucleotide binding]; other site 278197002820 Domain of unknown function (DUF955); Region: DUF955; cl01076 278197002821 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 278197002822 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278197002823 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278197002824 Int/Topo IB signature motif; other site 278197002825 Helix-turn-helix domains; Region: HTH; cl00088 278197002826 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 278197002827 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197002828 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197002829 putative active site [active] 278197002830 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197002831 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 278197002832 active site turn [active] 278197002833 phosphorylation site [posttranslational modification] 278197002834 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197002835 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 278197002836 HPr interaction site; other site 278197002837 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197002838 active site 278197002839 phosphorylation site [posttranslational modification] 278197002840 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 278197002841 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 278197002842 putative active site [active] 278197002843 Predicted acyl esterases [General function prediction only]; Region: COG2936 278197002844 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 278197002845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197002846 Helix-turn-helix domains; Region: HTH; cl00088 278197002847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197002848 dimerization interface [polypeptide binding]; other site 278197002849 Helix-turn-helix domains; Region: HTH; cl00088 278197002850 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197002851 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197002852 MucBP domain; Region: MucBP; pfam06458 278197002853 MucBP domain; Region: MucBP; pfam06458 278197002854 MucBP domain; Region: MucBP; pfam06458 278197002855 MucBP domain; Region: MucBP; pfam06458 278197002856 legume lectins; Region: lectin_L-type; cl14058 278197002857 homotetramer interaction site [polypeptide binding]; other site 278197002858 homodimer interaction site [polypeptide binding]; other site 278197002859 carbohydrate binding site [chemical binding]; other site 278197002860 metal binding site [ion binding]; metal-binding site 278197002861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197002862 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 278197002863 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 278197002864 active site 278197002865 multimer interface [polypeptide binding]; other site 278197002866 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197002867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197002868 amino acid transporter; Region: 2A0306; TIGR00909 278197002869 Spore germination protein; Region: Spore_permease; cl15802 278197002870 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 278197002871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197002872 putative substrate translocation pore; other site 278197002873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197002874 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 278197002875 nudix motif; other site 278197002876 Cupin domain; Region: Cupin_2; cl09118 278197002877 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 278197002878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197002879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002880 TPR motif; other site 278197002881 binding surface 278197002882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002883 binding surface 278197002884 TPR motif; other site 278197002885 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 278197002886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002887 binding surface 278197002888 TPR motif; other site 278197002889 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 278197002890 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 278197002891 active site 278197002892 catalytic residues [active] 278197002893 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 278197002894 ArsC family; Region: ArsC; pfam03960 278197002895 putative ArsC-like catalytic residues; other site 278197002896 putative TRX-like catalytic residues [active] 278197002897 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 278197002898 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 278197002899 C-terminal peptidase (prc); Region: prc; TIGR00225 278197002900 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 278197002901 protein binding site [polypeptide binding]; other site 278197002902 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 278197002903 Catalytic dyad [active] 278197002904 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 278197002905 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 278197002906 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 278197002907 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 278197002908 active site 278197002909 catalytic triad [active] 278197002910 oxyanion hole [active] 278197002911 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278197002912 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278197002913 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278197002914 Walker A/P-loop; other site 278197002915 ATP binding site [chemical binding]; other site 278197002916 Q-loop/lid; other site 278197002917 ABC transporter signature motif; other site 278197002918 Walker B; other site 278197002919 D-loop; other site 278197002920 H-loop/switch region; other site 278197002921 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197002922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197002923 substrate binding pocket [chemical binding]; other site 278197002924 membrane-bound complex binding site; other site 278197002925 hinge residues; other site 278197002926 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197002927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197002928 dimer interface [polypeptide binding]; other site 278197002929 conserved gate region; other site 278197002930 putative PBP binding loops; other site 278197002931 ABC-ATPase subunit interface; other site 278197002932 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 278197002933 folate binding site [chemical binding]; other site 278197002934 NADP+ binding site [chemical binding]; other site 278197002935 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 278197002936 dimerization interface [polypeptide binding]; other site 278197002937 active site 278197002938 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278197002939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197002940 Walker A/P-loop; other site 278197002941 ATP binding site [chemical binding]; other site 278197002942 Q-loop/lid; other site 278197002943 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197002944 ABC transporter signature motif; other site 278197002945 Walker B; other site 278197002946 D-loop; other site 278197002947 ABC transporter; Region: ABC_tran_2; pfam12848 278197002948 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197002949 chromosome segregation protein; Provisional; Region: PRK03918 278197002950 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 278197002951 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 278197002952 active site 278197002953 NTP binding site [chemical binding]; other site 278197002954 metal binding triad [ion binding]; metal-binding site 278197002955 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 278197002956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197002957 Uncharacterized conserved protein [Function unknown]; Region: COG1284 278197002958 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197002959 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197002960 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 278197002961 TIR domain; Region: TIR_2; cl15770 278197002962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002963 binding surface 278197002964 TPR motif; other site 278197002965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002966 binding surface 278197002967 TPR motif; other site 278197002968 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 278197002969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002970 binding surface 278197002971 TPR motif; other site 278197002972 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 278197002973 IHF dimer interface [polypeptide binding]; other site 278197002974 IHF - DNA interface [nucleotide binding]; other site 278197002975 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 278197002976 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 278197002977 RNA binding site [nucleotide binding]; other site 278197002978 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 278197002979 RNA binding site [nucleotide binding]; other site 278197002980 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 278197002981 RNA binding site [nucleotide binding]; other site 278197002982 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 278197002983 RNA binding site [nucleotide binding]; other site 278197002984 cytidylate kinase; Provisional; Region: cmk; PRK00023 278197002985 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 278197002986 CMP-binding site; other site 278197002987 The sites determining sugar specificity; other site 278197002988 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197002989 putative peptidoglycan binding site; other site 278197002990 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197002991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002992 ATP binding site [chemical binding]; other site 278197002993 putative Mg++ binding site [ion binding]; other site 278197002994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197002995 nucleotide binding region [chemical binding]; other site 278197002996 ATP-binding site [chemical binding]; other site 278197002997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 278197002998 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 278197002999 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197003000 RNA binding surface [nucleotide binding]; other site 278197003001 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 278197003002 active site 278197003003 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 278197003004 ScpA/B protein; Region: ScpA_ScpB; cl00598 278197003005 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 278197003006 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 278197003007 active site 278197003008 Int/Topo IB signature motif; other site 278197003009 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 278197003010 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278197003011 Protein of unknown function (DUF441); Region: DUF441; cl01041 278197003012 Protein of unknown function (DUF805); Region: DUF805; cl01224 278197003013 pyruvate kinase; Provisional; Region: PRK06354 278197003014 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278197003015 domain interfaces; other site 278197003016 active site 278197003017 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 278197003018 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 278197003019 active site 278197003020 ADP/pyrophosphate binding site [chemical binding]; other site 278197003021 dimerization interface [polypeptide binding]; other site 278197003022 allosteric effector site; other site 278197003023 fructose-1,6-bisphosphate binding site; other site 278197003024 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 278197003025 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 278197003026 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 278197003027 generic binding surface II; other site 278197003028 generic binding surface I; other site 278197003029 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 278197003030 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 278197003031 Clp amino terminal domain; Region: Clp_N; pfam02861 278197003032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003033 Walker A motif; other site 278197003034 ATP binding site [chemical binding]; other site 278197003035 Walker B motif; other site 278197003036 arginine finger; other site 278197003037 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 278197003038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003039 Walker A motif; other site 278197003040 ATP binding site [chemical binding]; other site 278197003041 Walker B motif; other site 278197003042 arginine finger; other site 278197003043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278197003044 Uncharacterized conserved protein [Function unknown]; Region: COG0327 278197003045 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 278197003046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003047 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 278197003048 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 278197003049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278197003050 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278197003051 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278197003052 DNA binding residues [nucleotide binding] 278197003053 DNA primase; Validated; Region: dnaG; PRK05667 278197003054 CHC2 zinc finger; Region: zf-CHC2; cl15369 278197003055 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 278197003056 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 278197003057 active site 278197003058 metal binding site [ion binding]; metal-binding site 278197003059 interdomain interaction site; other site 278197003060 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 278197003061 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 278197003062 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 278197003063 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 278197003064 dimer interface [polypeptide binding]; other site 278197003065 motif 1; other site 278197003066 active site 278197003067 motif 2; other site 278197003068 motif 3; other site 278197003069 DNA repair protein RecO; Region: reco; TIGR00613 278197003070 Recombination protein O N terminal; Region: RecO_N; cl15812 278197003071 Recombination protein O C terminal; Region: RecO_C; pfam02565 278197003072 GTPase Era; Reviewed; Region: era; PRK00089 278197003073 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 278197003074 G1 box; other site 278197003075 GTP/Mg2+ binding site [chemical binding]; other site 278197003076 Switch I region; other site 278197003077 G2 box; other site 278197003078 Switch II region; other site 278197003079 G3 box; other site 278197003080 G4 box; other site 278197003081 G5 box; other site 278197003082 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278197003083 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 278197003084 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 278197003085 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 278197003086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003087 GatB domain; Region: GatB_Yqey; cl11497 278197003088 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 278197003089 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 278197003090 endonuclease IV; Provisional; Region: PRK01060 278197003091 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 278197003092 AP (apurinic/apyrimidinic) site pocket; other site 278197003093 DNA interaction; other site 278197003094 Metal-binding active site; metal-binding site 278197003095 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197003096 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197003097 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197003098 Uncharacterized conserved protein [Function unknown]; Region: COG1284 278197003099 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197003100 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 278197003101 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 278197003102 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 278197003103 dimer interface [polypeptide binding]; other site 278197003104 anticodon binding site; other site 278197003105 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 278197003106 homodimer interface [polypeptide binding]; other site 278197003107 motif 1; other site 278197003108 active site 278197003109 motif 2; other site 278197003110 GAD domain; Region: GAD; pfam02938 278197003111 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278197003112 active site 278197003113 motif 3; other site 278197003114 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 278197003115 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 278197003116 dimer interface [polypeptide binding]; other site 278197003117 motif 1; other site 278197003118 active site 278197003119 motif 2; other site 278197003120 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 278197003121 anticodon binding site; other site 278197003122 Bacterial SH3 domain; Region: SH3_3; cl02551 278197003123 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 278197003124 active site 278197003125 metal binding site [ion binding]; metal-binding site 278197003126 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 278197003127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197003128 motif II; other site 278197003129 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 278197003130 putative active site [active] 278197003131 dimerization interface [polypeptide binding]; other site 278197003132 putative tRNAtyr binding site [nucleotide binding]; other site 278197003133 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 278197003134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197003135 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278197003136 synthetase active site [active] 278197003137 NTP binding site [chemical binding]; other site 278197003138 metal binding site [ion binding]; metal-binding site 278197003139 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 278197003140 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 278197003141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 278197003142 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 278197003143 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 278197003144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003145 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 278197003146 uracil transporter; Provisional; Region: PRK10720 278197003147 EamA-like transporter family; Region: EamA; cl01037 278197003148 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 278197003149 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 278197003150 dimer interface [polypeptide binding]; other site 278197003151 FMN binding site [chemical binding]; other site 278197003152 NADPH bind site [chemical binding]; other site 278197003153 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 278197003154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003155 active site 278197003156 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 278197003157 DHH family; Region: DHH; pfam01368 278197003158 DHHA1 domain; Region: DHHA1; pfam02272 278197003159 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 278197003160 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278197003161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003162 NAD(P) binding site [chemical binding]; other site 278197003163 active site 278197003164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278197003165 GTPase CgtA; Reviewed; Region: obgE; PRK12297 278197003166 GTP1/OBG; Region: GTP1_OBG; pfam01018 278197003167 Obg GTPase; Region: Obg; cd01898 278197003168 G1 box; other site 278197003169 GTP/Mg2+ binding site [chemical binding]; other site 278197003170 Switch I region; other site 278197003171 G2 box; other site 278197003172 G3 box; other site 278197003173 Switch II region; other site 278197003174 G4 box; other site 278197003175 G5 box; other site 278197003176 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 278197003177 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 278197003178 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 278197003179 GIY-YIG motif/motif A; other site 278197003180 active site 278197003181 catalytic site [active] 278197003182 putative DNA binding site [nucleotide binding]; other site 278197003183 metal binding site [ion binding]; metal-binding site 278197003184 UvrB/uvrC motif; Region: UVR; pfam02151 278197003185 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 278197003186 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 278197003187 DNA binding site [nucleotide binding] 278197003188 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278197003189 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278197003190 Walker A/P-loop; other site 278197003191 ATP binding site [chemical binding]; other site 278197003192 Q-loop/lid; other site 278197003193 ABC transporter signature motif; other site 278197003194 Walker B; other site 278197003195 D-loop; other site 278197003196 H-loop/switch region; other site 278197003197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197003198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197003199 substrate binding pocket [chemical binding]; other site 278197003200 membrane-bound complex binding site; other site 278197003201 hinge residues; other site 278197003202 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197003203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003204 dimer interface [polypeptide binding]; other site 278197003205 conserved gate region; other site 278197003206 putative PBP binding loops; other site 278197003207 ABC-ATPase subunit interface; other site 278197003208 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 278197003209 Predicted GTPase [General function prediction only]; Region: COG0218 278197003210 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 278197003211 G1 box; other site 278197003212 GTP/Mg2+ binding site [chemical binding]; other site 278197003213 Switch I region; other site 278197003214 G2 box; other site 278197003215 G3 box; other site 278197003216 Switch II region; other site 278197003217 G4 box; other site 278197003218 G5 box; other site 278197003219 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 278197003220 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 278197003221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003222 Walker A motif; other site 278197003223 ATP binding site [chemical binding]; other site 278197003224 Walker B motif; other site 278197003225 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278197003226 trigger factor; Provisional; Region: tig; PRK01490 278197003227 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 278197003228 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 278197003229 elongation factor Tu; Reviewed; Region: PRK00049 278197003230 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 278197003231 G1 box; other site 278197003232 GEF interaction site [polypeptide binding]; other site 278197003233 GTP/Mg2+ binding site [chemical binding]; other site 278197003234 Switch I region; other site 278197003235 G2 box; other site 278197003236 G3 box; other site 278197003237 Switch II region; other site 278197003238 G4 box; other site 278197003239 G5 box; other site 278197003240 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 278197003241 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 278197003242 Antibiotic Binding Site [chemical binding]; other site 278197003243 Ebola nucleoprotein; Region: Ebola_NP; pfam05505 278197003244 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 278197003245 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278197003246 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 278197003247 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 278197003248 16S/18S rRNA binding site [nucleotide binding]; other site 278197003249 S13e-L30e interaction site [polypeptide binding]; other site 278197003250 25S rRNA binding site [nucleotide binding]; other site 278197003251 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 278197003252 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 278197003253 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 278197003254 Competence protein; Region: Competence; cl00471 278197003255 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278197003256 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 278197003257 catalytic motif [active] 278197003258 Zn binding site [ion binding]; other site 278197003259 SLBB domain; Region: SLBB; pfam10531 278197003260 comEA protein; Region: comE; TIGR01259 278197003261 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 278197003262 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 278197003263 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 278197003264 active site 278197003265 (T/H)XGH motif; other site 278197003266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197003267 S-adenosylmethionine binding site [chemical binding]; other site 278197003268 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 278197003269 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 278197003270 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 278197003271 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 278197003272 G1 box; other site 278197003273 putative GEF interaction site [polypeptide binding]; other site 278197003274 GTP/Mg2+ binding site [chemical binding]; other site 278197003275 Switch I region; other site 278197003276 G2 box; other site 278197003277 G3 box; other site 278197003278 Switch II region; other site 278197003279 G4 box; other site 278197003280 G5 box; other site 278197003281 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 278197003282 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278197003283 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 278197003284 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 278197003285 active site 278197003286 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 278197003287 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 278197003288 active site 278197003289 catalytic residues [active] 278197003290 metal binding site [ion binding]; metal-binding site 278197003291 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 278197003292 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 278197003293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278197003294 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 278197003295 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197003296 putative peptidoglycan binding site; other site 278197003297 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 278197003298 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197003299 putative peptidoglycan binding site; other site 278197003300 NlpC/P60 family; Region: NLPC_P60; cl11438 278197003301 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278197003302 active site 278197003303 phosphorylation site [posttranslational modification] 278197003304 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 278197003305 active site 278197003306 P-loop; other site 278197003307 phosphorylation site [posttranslational modification] 278197003308 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197003309 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 278197003310 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 278197003311 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 278197003312 putative substrate binding site [chemical binding]; other site 278197003313 putative ATP binding site [chemical binding]; other site 278197003314 Helix-turn-helix domains; Region: HTH; cl00088 278197003315 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278197003316 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 278197003317 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278197003318 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 278197003319 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 278197003320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003321 active site 278197003322 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 278197003323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003324 Family description; Region: UvrD_C_2; cl15862 278197003325 Tetratricopeptide repeat; Region: TPR_12; pfam13424 278197003326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 278197003327 binding surface 278197003328 TPR motif; other site 278197003329 Tetratricopeptide repeat; Region: TPR_16; pfam13432 278197003330 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197003331 catalytic core [active] 278197003332 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 278197003333 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 278197003334 Putative amino acid metabolism; Region: DUF1831; pfam08866 278197003335 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278197003336 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 278197003337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197003338 catalytic residue [active] 278197003339 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 278197003340 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 278197003341 dimer interface [polypeptide binding]; other site 278197003342 ADP-ribose binding site [chemical binding]; other site 278197003343 active site 278197003344 nudix motif; other site 278197003345 metal binding site [ion binding]; metal-binding site 278197003346 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 278197003347 DNA-binding site [nucleotide binding]; DNA binding site 278197003348 RNA-binding motif; other site 278197003349 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 278197003350 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197003351 active site 278197003352 HIGH motif; other site 278197003353 nucleotide binding site [chemical binding]; other site 278197003354 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278197003355 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 278197003356 active site 278197003357 KMSKS motif; other site 278197003358 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 278197003359 tRNA binding surface [nucleotide binding]; other site 278197003360 anticodon binding site; other site 278197003361 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278197003362 DivIVA protein; Region: DivIVA; pfam05103 278197003363 DivIVA domain; Region: DivI1A_domain; TIGR03544 278197003364 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 278197003365 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 278197003366 YGGT family; Region: YGGT; cl00508 278197003367 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 278197003368 nucleotide binding site [chemical binding]; other site 278197003369 SulA interaction site; other site 278197003370 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 278197003371 Cell division protein FtsA; Region: FtsA; cl11496 278197003372 Cell division protein FtsA; Region: FtsA; cl11496 278197003373 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 278197003374 Cell division protein FtsQ; Region: FtsQ; pfam03799 278197003375 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 278197003376 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 278197003377 active site 278197003378 homodimer interface [polypeptide binding]; other site 278197003379 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 278197003380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197003381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197003382 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 278197003383 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 278197003384 Mg++ binding site [ion binding]; other site 278197003385 putative catalytic motif [active] 278197003386 putative substrate binding site [chemical binding]; other site 278197003387 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 278197003388 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 278197003389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197003390 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 278197003391 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 278197003392 Septum formation initiator; Region: DivIC; cl11433 278197003393 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 278197003394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003395 cell division protein MraZ; Reviewed; Region: PRK00326 278197003396 MraZ protein; Region: MraZ; pfam02381 278197003397 MraZ protein; Region: MraZ; pfam02381 278197003398 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 278197003399 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 278197003400 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 278197003401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003402 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 278197003403 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278197003404 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278197003405 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 278197003406 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 278197003407 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 278197003408 CutC family; Region: CutC; cl01218 278197003409 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 278197003410 MgtE intracellular N domain; Region: MgtE_N; cl15244 278197003411 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 278197003412 Divalent cation transporter; Region: MgtE; cl00786 278197003413 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 278197003414 active site 278197003415 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278197003416 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 278197003417 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278197003418 synthetase active site [active] 278197003419 NTP binding site [chemical binding]; other site 278197003420 metal binding site [ion binding]; metal-binding site 278197003421 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 278197003422 Thioredoxin; Region: Thioredoxin_5; pfam13743 278197003423 catalytic residues [active] 278197003424 Competence protein CoiA-like family; Region: CoiA; cl11541 278197003425 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 278197003426 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 278197003427 ArsC family; Region: ArsC; pfam03960 278197003428 putative catalytic residues [active] 278197003429 thiol/disulfide switch; other site 278197003430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278197003431 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278197003432 RNA binding site [nucleotide binding]; other site 278197003433 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278197003434 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 278197003435 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 278197003436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197003437 active site 278197003438 motif I; other site 278197003439 motif II; other site 278197003440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197003441 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 278197003442 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 278197003443 putative active site [active] 278197003444 putative metal binding site [ion binding]; other site 278197003445 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 278197003446 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 278197003447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003448 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 278197003449 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 278197003450 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 278197003451 Type II/IV secretion system protein; Region: T2SE; pfam00437 278197003452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003453 Walker A motif; other site 278197003454 ATP binding site [chemical binding]; other site 278197003455 Walker B motif; other site 278197003456 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278197003457 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 278197003458 substrate binding site [chemical binding]; other site 278197003459 dimer interface [polypeptide binding]; other site 278197003460 ATP binding site [chemical binding]; other site 278197003461 Transcriptional regulator; Region: Transcrip_reg; cl00361 278197003462 DNA polymerase IV; Reviewed; Region: PRK03103 278197003463 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 278197003464 active site 278197003465 DNA binding site [nucleotide binding] 278197003466 elongation factor P; Validated; Region: PRK00529 278197003467 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 278197003468 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 278197003469 RNA binding site [nucleotide binding]; other site 278197003470 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 278197003471 RNA binding site [nucleotide binding]; other site 278197003472 Isochorismatase family; Region: Isochorismatase; pfam00857 278197003473 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 278197003474 catalytic triad [active] 278197003475 conserved cis-peptide bond; other site 278197003476 adenylosuccinate lyase; Provisional; Region: PRK07492 278197003477 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 278197003478 tetramer interface [polypeptide binding]; other site 278197003479 active site 278197003480 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 278197003481 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 278197003482 GDP-binding site [chemical binding]; other site 278197003483 ACT binding site; other site 278197003484 IMP binding site; other site 278197003485 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 278197003486 amphipathic channel; other site 278197003487 Asn-Pro-Ala signature motifs; other site 278197003488 catabolite control protein A; Region: ccpA; TIGR01481 278197003489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197003490 DNA binding site [nucleotide binding] 278197003491 domain linker motif; other site 278197003492 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 278197003493 dimerization interface [polypeptide binding]; other site 278197003494 effector binding site; other site 278197003495 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 278197003496 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 278197003497 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 278197003498 active site 278197003499 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 278197003500 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 278197003501 PYR/PP interface [polypeptide binding]; other site 278197003502 dimer interface [polypeptide binding]; other site 278197003503 tetramer interface [polypeptide binding]; other site 278197003504 TPP binding site [chemical binding]; other site 278197003505 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278197003506 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 278197003507 TPP-binding site [chemical binding]; other site 278197003508 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 278197003509 Mechanosensitive ion channel; Region: MS_channel; pfam00924 278197003510 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 278197003511 active site 278197003512 dimerization interface [polypeptide binding]; other site 278197003513 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 278197003514 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278197003515 catalytic residues [active] 278197003516 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 278197003517 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 278197003518 Walker A/P-loop; other site 278197003519 ATP binding site [chemical binding]; other site 278197003520 Q-loop/lid; other site 278197003521 ABC transporter signature motif; other site 278197003522 Walker B; other site 278197003523 D-loop; other site 278197003524 H-loop/switch region; other site 278197003525 Smr domain; Region: Smr; cl02619 278197003526 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 278197003527 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 278197003528 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 278197003529 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 278197003530 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 278197003531 motif 1; other site 278197003532 active site 278197003533 motif 2; other site 278197003534 motif 3; other site 278197003535 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 278197003536 DHHA1 domain; Region: DHHA1; pfam02272 278197003537 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278197003538 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197003539 ATP binding site [chemical binding]; other site 278197003540 Mg++ binding site [ion binding]; other site 278197003541 motif III; other site 278197003542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197003543 nucleotide binding region [chemical binding]; other site 278197003544 ATP-binding site [chemical binding]; other site 278197003545 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 278197003546 DHH family; Region: DHH; pfam01368 278197003547 DHHA1 domain; Region: DHHA1; pfam02272 278197003548 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 278197003549 active site 278197003550 DNA polymerase IV; Validated; Region: PRK02406 278197003551 DNA binding site [nucleotide binding] 278197003552 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 278197003553 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 278197003554 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 278197003555 Preprotein translocase subunit; Region: YajC; cl00806 278197003556 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 278197003557 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 278197003558 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 278197003559 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 278197003560 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 278197003561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003562 Walker A motif; other site 278197003563 ATP binding site [chemical binding]; other site 278197003564 Walker B motif; other site 278197003565 arginine finger; other site 278197003566 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 278197003567 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 278197003568 RuvA N terminal domain; Region: RuvA_N; pfam01330 278197003569 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 278197003570 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 278197003571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197003572 ATP binding site [chemical binding]; other site 278197003573 Mg2+ binding site [ion binding]; other site 278197003574 G-X-G motif; other site 278197003575 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 278197003576 ATP binding site [chemical binding]; other site 278197003577 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 278197003578 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 278197003579 MutS domain I; Region: MutS_I; pfam01624 278197003580 MutS domain II; Region: MutS_II; pfam05188 278197003581 MutS family domain IV; Region: MutS_IV; pfam05190 278197003582 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 278197003583 Walker A/P-loop; other site 278197003584 ATP binding site [chemical binding]; other site 278197003585 Q-loop/lid; other site 278197003586 ABC transporter signature motif; other site 278197003587 Walker B; other site 278197003588 D-loop; other site 278197003589 H-loop/switch region; other site 278197003590 phosphodiesterase; Provisional; Region: PRK12704 278197003591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197003592 recombinase A; Provisional; Region: recA; PRK09354 278197003593 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 278197003594 hexamer interface [polypeptide binding]; other site 278197003595 Walker A motif; other site 278197003596 ATP binding site [chemical binding]; other site 278197003597 Walker B motif; other site 278197003598 competence damage-inducible protein A; Provisional; Region: PRK00549 278197003599 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 278197003600 putative MPT binding site; other site 278197003601 Competence-damaged protein; Region: CinA; cl00666 278197003602 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 278197003603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197003604 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 278197003605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003606 NAD(P) binding site [chemical binding]; other site 278197003607 active site 278197003608 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 278197003609 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 278197003610 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 278197003611 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 278197003612 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 278197003613 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 278197003614 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 278197003615 putative active site [active] 278197003616 catalytic site [active] 278197003617 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 278197003618 putative active site [active] 278197003619 catalytic site [active] 278197003620 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197003621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197003622 substrate binding pocket [chemical binding]; other site 278197003623 membrane-bound complex binding site; other site 278197003624 hinge residues; other site 278197003625 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197003626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003627 Walker A/P-loop; other site 278197003628 ATP binding site [chemical binding]; other site 278197003629 Q-loop/lid; other site 278197003630 ABC transporter signature motif; other site 278197003631 Walker B; other site 278197003632 D-loop; other site 278197003633 H-loop/switch region; other site 278197003634 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197003635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003636 dimer interface [polypeptide binding]; other site 278197003637 conserved gate region; other site 278197003638 putative PBP binding loops; other site 278197003639 ABC-ATPase subunit interface; other site 278197003640 rod shape-determining protein MreD; Region: MreD; cl01087 278197003641 rod shape-determining protein MreC; Provisional; Region: PRK13922 278197003642 rod shape-determining protein MreC; Region: MreC; pfam04085 278197003643 hypothetical protein; Reviewed; Region: PRK00024 278197003644 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 278197003645 MPN+ (JAMM) motif; other site 278197003646 Zinc-binding site [ion binding]; other site 278197003647 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 278197003648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197003649 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 278197003650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197003651 active site 278197003652 HIGH motif; other site 278197003653 nucleotide binding site [chemical binding]; other site 278197003654 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278197003655 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 278197003656 active site 278197003657 KMSKS motif; other site 278197003658 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 278197003659 tRNA binding surface [nucleotide binding]; other site 278197003660 anticodon binding site; other site 278197003661 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 278197003662 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 278197003663 dimer interface [polypeptide binding]; other site 278197003664 catalytic triad [active] 278197003665 peroxidatic and resolving cysteines [active] 278197003666 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 278197003667 THUMP domain; Region: THUMP; cl12076 278197003668 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 278197003669 Ligand Binding Site [chemical binding]; other site 278197003670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278197003671 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 278197003672 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197003673 catalytic residue [active] 278197003674 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 278197003675 GAF domain; Region: GAF; cl15785 278197003676 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 278197003677 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 278197003678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197003679 RNA binding surface [nucleotide binding]; other site 278197003680 recombination factor protein RarA; Reviewed; Region: PRK13342 278197003681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003682 Walker A motif; other site 278197003683 ATP binding site [chemical binding]; other site 278197003684 Walker B motif; other site 278197003685 arginine finger; other site 278197003686 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 278197003687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197003688 Ligand Binding Site [chemical binding]; other site 278197003689 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 278197003690 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 278197003691 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 278197003692 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197003693 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 278197003694 amino acid transporter; Region: 2A0306; TIGR00909 278197003695 Spore germination protein; Region: Spore_permease; cl15802 278197003696 Spore germination protein; Region: Spore_permease; cl15802 278197003697 Protein of unknown function (DUF975); Region: DUF975; cl10504 278197003698 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278197003699 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 278197003700 Walker A/P-loop; other site 278197003701 ATP binding site [chemical binding]; other site 278197003702 Q-loop/lid; other site 278197003703 ABC transporter signature motif; other site 278197003704 Walker B; other site 278197003705 D-loop; other site 278197003706 H-loop/switch region; other site 278197003707 Predicted transcriptional regulators [Transcription]; Region: COG1725 278197003708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197003709 DNA-binding site [nucleotide binding]; DNA binding site 278197003710 NMT1-like family; Region: NMT1_2; cl15260 278197003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003712 dimer interface [polypeptide binding]; other site 278197003713 conserved gate region; other site 278197003714 ABC-ATPase subunit interface; other site 278197003715 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 278197003716 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 278197003717 Walker A/P-loop; other site 278197003718 ATP binding site [chemical binding]; other site 278197003719 Q-loop/lid; other site 278197003720 ABC transporter signature motif; other site 278197003721 Walker B; other site 278197003722 D-loop; other site 278197003723 H-loop/switch region; other site 278197003724 NIL domain; Region: NIL; cl09633 278197003725 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 278197003726 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 278197003727 Haemolytic domain; Region: Haemolytic; cl00506 278197003728 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 278197003729 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 278197003730 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 278197003731 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 278197003732 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 278197003733 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 278197003734 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 278197003735 alpha subunit interaction interface [polypeptide binding]; other site 278197003736 Walker A motif; other site 278197003737 ATP binding site [chemical binding]; other site 278197003738 Walker B motif; other site 278197003739 inhibitor binding site; inhibition site 278197003740 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 278197003741 ATP synthase; Region: ATP-synt; cl00365 278197003742 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 278197003743 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 278197003744 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 278197003745 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 278197003746 beta subunit interaction interface [polypeptide binding]; other site 278197003747 Walker A motif; other site 278197003748 ATP binding site [chemical binding]; other site 278197003749 Walker B motif; other site 278197003750 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 278197003751 Plant ATP synthase F0; Region: YMF19; cl07975 278197003752 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 278197003753 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 278197003754 Plant ATP synthase F0; Region: YMF19; cl07975 278197003755 ATP synthase subunit C; Region: ATP-synt_C; cl00466 278197003756 ATP synthase A chain; Region: ATP-synt_A; cl00413 278197003757 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197003758 phosphodiesterase; Provisional; Region: PRK12704 278197003759 FtsX-like permease family; Region: FtsX; cl15850 278197003760 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197003761 FtsX-like permease family; Region: FtsX; cl15850 278197003762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197003763 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 278197003764 Walker A/P-loop; other site 278197003765 ATP binding site [chemical binding]; other site 278197003766 Q-loop/lid; other site 278197003767 ABC transporter signature motif; other site 278197003768 Walker B; other site 278197003769 D-loop; other site 278197003770 H-loop/switch region; other site 278197003771 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003772 active site 278197003773 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 278197003774 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 278197003775 dimer interface [polypeptide binding]; other site 278197003776 active site 278197003777 glycine-pyridoxal phosphate binding site [chemical binding]; other site 278197003778 folate binding site [chemical binding]; other site 278197003779 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 278197003780 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 278197003781 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 278197003782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197003783 S-adenosylmethionine binding site [chemical binding]; other site 278197003784 peptide chain release factor 1; Validated; Region: prfA; PRK00591 278197003785 RF-1 domain; Region: RF-1; cl02875 278197003786 RF-1 domain; Region: RF-1; cl02875 278197003787 thymidine kinase; Provisional; Region: PRK04296 278197003788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003789 ATP binding site [chemical binding]; other site 278197003790 Walker A motif; other site 278197003791 Walker B motif; other site 278197003792 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 278197003793 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197003794 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 278197003795 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 278197003796 catalytic triad [active] 278197003797 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 278197003798 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 278197003799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197003800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278197003801 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278197003802 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 278197003803 Walker A/P-loop; other site 278197003804 ATP binding site [chemical binding]; other site 278197003805 Q-loop/lid; other site 278197003806 ABC transporter signature motif; other site 278197003807 Walker B; other site 278197003808 D-loop; other site 278197003809 H-loop/switch region; other site 278197003810 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278197003811 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278197003812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003813 Walker A/P-loop; other site 278197003814 ATP binding site [chemical binding]; other site 278197003815 Q-loop/lid; other site 278197003816 ABC transporter signature motif; other site 278197003817 Walker B; other site 278197003818 D-loop; other site 278197003819 H-loop/switch region; other site 278197003820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197003821 Helix-turn-helix domains; Region: HTH; cl00088 278197003822 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 278197003823 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 278197003824 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 278197003825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278197003826 active site residue [active] 278197003827 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 278197003828 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 278197003829 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197003830 PAS domain; Region: PAS_10; pfam13596 278197003831 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197003832 ApbE family; Region: ApbE; cl00643 278197003833 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 278197003834 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 278197003835 active site 278197003836 dimer interface [polypeptide binding]; other site 278197003837 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 278197003838 dimer interface [polypeptide binding]; other site 278197003839 active site 278197003840 Sugar transport protein; Region: Sugar_transport; pfam06800 278197003841 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 278197003842 hypothetical protein; Provisional; Region: PRK08185 278197003843 intersubunit interface [polypeptide binding]; other site 278197003844 active site 278197003845 zinc binding site [ion binding]; other site 278197003846 Na+ binding site [ion binding]; other site 278197003847 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 278197003848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278197003849 dimerization interface [polypeptide binding]; other site 278197003850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197003851 dimer interface [polypeptide binding]; other site 278197003852 phosphorylation site [posttranslational modification] 278197003853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197003854 ATP binding site [chemical binding]; other site 278197003855 Mg2+ binding site [ion binding]; other site 278197003856 G-X-G motif; other site 278197003857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197003858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197003859 active site 278197003860 phosphorylation site [posttranslational modification] 278197003861 intermolecular recognition site; other site 278197003862 dimerization interface [polypeptide binding]; other site 278197003863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197003864 DNA binding site [nucleotide binding] 278197003865 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197003866 putative peptidoglycan binding site; other site 278197003867 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 278197003868 putative peptidoglycan binding site; other site 278197003869 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278197003870 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 278197003871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197003872 Coenzyme A binding pocket [chemical binding]; other site 278197003873 polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591 278197003874 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 278197003875 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 278197003876 Citrate transporter; Region: CitMHS; pfam03600 278197003877 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 278197003878 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 278197003879 N- and C-terminal domain interface [polypeptide binding]; other site 278197003880 putative active site [active] 278197003881 catalytic site [active] 278197003882 metal binding site [ion binding]; metal-binding site 278197003883 carbohydrate binding site [chemical binding]; other site 278197003884 ATP binding site [chemical binding]; other site 278197003885 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 278197003886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003887 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197003888 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197003889 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197003890 putative active site [active] 278197003891 Mrr N-terminal domain; Region: Mrr_N; pfam14338 278197003892 Restriction endonuclease; Region: Mrr_cat; cl00516 278197003893 TRAM domain; Region: TRAM; cl01282 278197003894 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 278197003895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197003897 S-adenosylmethionine binding site [chemical binding]; other site 278197003898 putative lipid kinase; Reviewed; Region: PRK13055 278197003899 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278197003900 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 278197003901 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 278197003902 GatB domain; Region: GatB_Yqey; cl11497 278197003903 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 278197003904 Amidase; Region: Amidase; cl11426 278197003905 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 278197003906 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 278197003907 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 278197003908 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197003909 Family description; Region: UvrD_C_2; cl15862 278197003910 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 278197003911 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197003912 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 278197003913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003914 active site 278197003915 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278197003916 Predicted membrane protein [Function unknown]; Region: COG4684 278197003917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003918 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 278197003919 PLD-like domain; Region: PLDc_2; pfam13091 278197003920 putative homodimer interface [polypeptide binding]; other site 278197003921 putative active site [active] 278197003922 catalytic site [active] 278197003923 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197003924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197003925 ATP binding site [chemical binding]; other site 278197003926 putative Mg++ binding site [ion binding]; other site 278197003927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197003928 nucleotide binding region [chemical binding]; other site 278197003929 ATP-binding site [chemical binding]; other site 278197003930 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 278197003931 Ferritin-like domain; Region: Ferritin; pfam00210 278197003932 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 278197003933 dimerization interface [polypeptide binding]; other site 278197003934 DPS ferroxidase diiron center [ion binding]; other site 278197003935 ion pore; other site 278197003936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278197003937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197003938 salt bridge; other site 278197003939 non-specific DNA binding site [nucleotide binding]; other site 278197003940 sequence-specific DNA binding site [nucleotide binding]; other site 278197003941 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 278197003942 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 278197003943 23S rRNA interface [nucleotide binding]; other site 278197003944 L3 interface [polypeptide binding]; other site 278197003945 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 278197003946 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 278197003947 dimerization interface 3.5A [polypeptide binding]; other site 278197003948 active site 278197003949 Cobalt transport protein; Region: CbiQ; cl00463 278197003950 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278197003951 Q-loop/lid; other site 278197003952 ABC transporter signature motif; other site 278197003953 Walker B; other site 278197003954 D-loop; other site 278197003955 H-loop/switch region; other site 278197003956 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 278197003957 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278197003958 Walker A/P-loop; other site 278197003959 ATP binding site [chemical binding]; other site 278197003960 Q-loop/lid; other site 278197003961 ABC transporter signature motif; other site 278197003962 Walker B; other site 278197003963 D-loop; other site 278197003964 H-loop/switch region; other site 278197003965 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 278197003966 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 278197003967 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 278197003968 alphaNTD homodimer interface [polypeptide binding]; other site 278197003969 alphaNTD - beta interaction site [polypeptide binding]; other site 278197003970 alphaNTD - beta' interaction site [polypeptide binding]; other site 278197003971 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 278197003972 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 278197003973 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 278197003974 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 278197003975 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 278197003976 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 278197003977 rRNA binding site [nucleotide binding]; other site 278197003978 predicted 30S ribosome binding site; other site 278197003979 adenylate kinase; Reviewed; Region: adk; PRK00279 278197003980 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 278197003981 AMP-binding site [chemical binding]; other site 278197003982 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 278197003983 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 278197003984 SecY translocase; Region: SecY; pfam00344 278197003985 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 278197003986 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 278197003987 23S rRNA binding site [nucleotide binding]; other site 278197003988 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 278197003989 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 278197003990 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 278197003991 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 278197003992 5S rRNA interface [nucleotide binding]; other site 278197003993 L27 interface [polypeptide binding]; other site 278197003994 23S rRNA interface [nucleotide binding]; other site 278197003995 L5 interface [polypeptide binding]; other site 278197003996 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 278197003997 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 278197003998 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 278197003999 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 278197004000 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 278197004001 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 278197004002 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 278197004003 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 278197004004 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 278197004005 KOW motif; Region: KOW; cl00354 278197004006 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 278197004007 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 278197004008 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 278197004009 23S rRNA interface [nucleotide binding]; other site 278197004010 putative translocon interaction site; other site 278197004011 signal recognition particle (SRP54) interaction site; other site 278197004012 L23 interface [polypeptide binding]; other site 278197004013 trigger factor interaction site; other site 278197004014 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 278197004015 23S rRNA interface [nucleotide binding]; other site 278197004016 5S rRNA interface [nucleotide binding]; other site 278197004017 putative antibiotic binding site [chemical binding]; other site 278197004018 L25 interface [polypeptide binding]; other site 278197004019 L27 interface [polypeptide binding]; other site 278197004020 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 278197004021 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 278197004022 G-X-X-G motif; other site 278197004023 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 278197004024 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 278197004025 putative translocon binding site; other site 278197004026 protein-rRNA interface [nucleotide binding]; other site 278197004027 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 278197004028 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 278197004029 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 278197004030 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 278197004031 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 278197004032 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 278197004033 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 278197004034 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 278197004035 elongation factor G; Reviewed; Region: PRK12739 278197004036 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 278197004037 G1 box; other site 278197004038 putative GEF interaction site [polypeptide binding]; other site 278197004039 GTP/Mg2+ binding site [chemical binding]; other site 278197004040 Switch I region; other site 278197004041 G2 box; other site 278197004042 G3 box; other site 278197004043 Switch II region; other site 278197004044 G4 box; other site 278197004045 G5 box; other site 278197004046 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 278197004047 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 278197004048 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 278197004049 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 278197004050 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 278197004051 16S rRNA interaction site [nucleotide binding]; other site 278197004052 streptomycin interaction site [chemical binding]; other site 278197004053 23S rRNA interaction site [nucleotide binding]; other site 278197004054 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 278197004055 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 278197004056 active site 278197004057 dimerization interface [polypeptide binding]; other site 278197004058 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 278197004059 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 278197004060 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 278197004061 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 278197004062 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 278197004063 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 278197004064 cleft; other site 278197004065 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 278197004066 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 278197004067 DNA binding site [nucleotide binding] 278197004068 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 278197004069 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 278197004070 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 278197004071 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 278197004072 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 278197004073 RPB1 interaction site [polypeptide binding]; other site 278197004074 RPB10 interaction site [polypeptide binding]; other site 278197004075 RPB11 interaction site [polypeptide binding]; other site 278197004076 RPB3 interaction site [polypeptide binding]; other site 278197004077 RPB12 interaction site [polypeptide binding]; other site 278197004078 Clp protease ATP binding subunit; Region: clpC; CHL00095 278197004079 Clp amino terminal domain; Region: Clp_N; pfam02861 278197004080 Clp amino terminal domain; Region: Clp_N; pfam02861 278197004081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004082 Walker A motif; other site 278197004083 ATP binding site [chemical binding]; other site 278197004084 Walker B motif; other site 278197004085 arginine finger; other site 278197004086 UvrB/uvrC motif; Region: UVR; pfam02151 278197004087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004088 Walker A motif; other site 278197004089 ATP binding site [chemical binding]; other site 278197004090 Walker B motif; other site 278197004091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278197004092 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 278197004093 seryl-tRNA synthetase; Provisional; Region: PRK05431 278197004094 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 278197004095 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 278197004096 dimer interface [polypeptide binding]; other site 278197004097 active site 278197004098 motif 1; other site 278197004099 motif 2; other site 278197004100 motif 3; other site 278197004101 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 278197004102 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 278197004103 Substrate-binding site [chemical binding]; other site 278197004104 Substrate specificity [chemical binding]; other site 278197004105 lysine transporter; Provisional; Region: PRK10836 278197004106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197004107 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278197004108 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 278197004109 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278197004110 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197004111 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197004112 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 278197004113 Uncharacterized conserved protein [Function unknown]; Region: COG2966 278197004114 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 278197004115 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 278197004116 DNA-binding site [nucleotide binding]; DNA binding site 278197004117 RNA-binding motif; other site 278197004118 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 278197004119 active site 278197004120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197004121 phosphodiesterase; Provisional; Region: PRK12704 278197004122 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278197004123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278197004124 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 278197004125 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 278197004126 active site 278197004127 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 278197004128 xanthine permease; Region: pbuX; TIGR03173 278197004129 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 278197004130 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197004131 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 278197004132 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 278197004133 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197004134 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 278197004135 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 278197004136 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 278197004137 purine monophosphate binding site [chemical binding]; other site 278197004138 dimer interface [polypeptide binding]; other site 278197004139 putative catalytic residues [active] 278197004140 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 278197004141 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 278197004142 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 278197004143 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 278197004144 active site 278197004145 substrate binding site [chemical binding]; other site 278197004146 cosubstrate binding site; other site 278197004147 catalytic site [active] 278197004148 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 278197004149 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 278197004150 dimerization interface [polypeptide binding]; other site 278197004151 putative ATP binding site [chemical binding]; other site 278197004152 amidophosphoribosyltransferase; Provisional; Region: PRK07272 278197004153 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 278197004154 active site 278197004155 tetramer interface [polypeptide binding]; other site 278197004156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197004157 active site 278197004158 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 278197004159 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 278197004160 dimerization interface [polypeptide binding]; other site 278197004161 ATP binding site [chemical binding]; other site 278197004162 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 278197004163 dimerization interface [polypeptide binding]; other site 278197004164 ATP binding site [chemical binding]; other site 278197004165 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 278197004166 putative active site [active] 278197004167 catalytic triad [active] 278197004168 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 278197004169 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 278197004170 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 278197004171 ATP binding site [chemical binding]; other site 278197004172 active site 278197004173 substrate binding site [chemical binding]; other site 278197004174 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 278197004175 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278197004176 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197004177 AIR carboxylase; Region: AIRC; cl00310 278197004178 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 278197004179 catalytic triad [active] 278197004180 conserved cis-peptide bond; other site 278197004181 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 278197004182 dimer interface [polypeptide binding]; other site 278197004183 active site 278197004184 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 278197004185 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 278197004186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197004187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197004188 UGMP family protein; Validated; Region: PRK09604 278197004189 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 278197004190 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 278197004191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004192 Coenzyme A binding pocket [chemical binding]; other site 278197004193 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 278197004194 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 278197004195 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 278197004196 NAD binding site [chemical binding]; other site 278197004197 homodimer interface [polypeptide binding]; other site 278197004198 active site 278197004199 substrate binding site [chemical binding]; other site 278197004200 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 278197004201 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 278197004202 active site 278197004203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278197004204 Predicted methyltransferases [General function prediction only]; Region: COG0313 278197004205 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278197004206 Protein of unknown function (DUF972); Region: DUF972; pfam06156 278197004207 DNA polymerase III subunit delta'; Validated; Region: PRK08058 278197004208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197004209 Nitrogen regulatory protein P-II; Region: P-II; cl00412 278197004210 thymidylate kinase; Validated; Region: tmk; PRK00698 278197004211 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 278197004212 TMP-binding site; other site 278197004213 ATP-binding site [chemical binding]; other site 278197004214 recombination protein RecR; Reviewed; Region: recR; PRK00076 278197004215 RecR protein; Region: RecR; pfam02132 278197004216 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 278197004217 putative active site [active] 278197004218 putative metal-binding site [ion binding]; other site 278197004219 tetramer interface [polypeptide binding]; other site 278197004220 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 278197004221 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 278197004222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004223 Walker A motif; other site 278197004224 ATP binding site [chemical binding]; other site 278197004225 Walker B motif; other site 278197004226 arginine finger; other site 278197004227 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 278197004228 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 278197004229 nucleoside/Zn binding site; other site 278197004230 dimer interface [polypeptide binding]; other site 278197004231 catalytic motif [active] 278197004232 Methyltransferase domain; Region: Methyltransf_31; pfam13847 278197004233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197004234 S-adenosylmethionine binding site [chemical binding]; other site 278197004235 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 278197004236 catalytic residues [active] 278197004237 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 278197004238 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 278197004239 Class I ribonucleotide reductase; Region: RNR_I; cd01679 278197004240 active site 278197004241 dimer interface [polypeptide binding]; other site 278197004242 catalytic residues [active] 278197004243 effector binding site; other site 278197004244 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 278197004245 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 278197004246 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 278197004247 dimer interface [polypeptide binding]; other site 278197004248 putative radical transfer pathway; other site 278197004249 diiron center [ion binding]; other site 278197004250 tyrosyl radical; other site 278197004251 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 278197004252 core dimer interface [polypeptide binding]; other site 278197004253 peripheral dimer interface [polypeptide binding]; other site 278197004254 L10 interface [polypeptide binding]; other site 278197004255 L11 interface [polypeptide binding]; other site 278197004256 putative EF-Tu interaction site [polypeptide binding]; other site 278197004257 putative EF-G interaction site [polypeptide binding]; other site 278197004258 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 278197004259 23S rRNA interface [nucleotide binding]; other site 278197004260 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 278197004261 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 278197004262 mRNA/rRNA interface [nucleotide binding]; other site 278197004263 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 278197004264 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 278197004265 23S rRNA interface [nucleotide binding]; other site 278197004266 L7/L12 interface [polypeptide binding]; other site 278197004267 putative thiostrepton binding site; other site 278197004268 L25 interface [polypeptide binding]; other site 278197004269 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 278197004270 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 278197004271 putative homodimer interface [polypeptide binding]; other site 278197004272 KOW motif; Region: KOW; cl00354 278197004273 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 278197004274 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 278197004275 RNA polymerase factor sigma-70; Validated; Region: PRK08295 278197004276 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 278197004277 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 278197004278 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278197004279 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 278197004280 active site 278197004281 metal binding site [ion binding]; metal-binding site 278197004282 dimerization interface [polypeptide binding]; other site 278197004283 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 278197004284 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 278197004285 active site 278197004286 HIGH motif; other site 278197004287 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 278197004288 KMSKS motif; other site 278197004289 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 278197004290 tRNA binding surface [nucleotide binding]; other site 278197004291 anticodon binding site; other site 278197004292 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 278197004293 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 278197004294 active site 278197004295 HIGH motif; other site 278197004296 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 278197004297 active site 278197004298 KMSKS motif; other site 278197004299 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 278197004300 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 278197004301 putative active site [active] 278197004302 DNA repair protein RadA; Provisional; Region: PRK11823 278197004303 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 278197004304 Walker A motif/ATP binding site; other site 278197004305 ATP binding site [chemical binding]; other site 278197004306 Walker B motif; other site 278197004307 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 278197004308 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 278197004309 trimer interface [polypeptide binding]; other site 278197004310 active site 278197004311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004312 Coenzyme A binding pocket [chemical binding]; other site 278197004313 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 278197004314 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197004315 active site 278197004316 dimer interface [polypeptide binding]; other site 278197004317 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 278197004318 trimer interface [polypeptide binding]; other site 278197004319 active site 278197004320 G bulge; other site 278197004321 Helix-turn-helix domains; Region: HTH; cl00088 278197004322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004323 putative substrate translocation pore; other site 278197004324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197004325 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004326 catalytic core [active] 278197004327 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004328 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 278197004329 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 278197004330 dimer interface [polypeptide binding]; other site 278197004331 active site 278197004332 CoA binding pocket [chemical binding]; other site 278197004333 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197004334 active site 278197004335 phosphorylation site [posttranslational modification] 278197004336 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 278197004337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004338 Walker A motif; other site 278197004339 ATP binding site [chemical binding]; other site 278197004340 Walker B motif; other site 278197004341 arginine finger; other site 278197004342 Transcriptional antiterminator [Transcription]; Region: COG3933 278197004343 PRD domain; Region: PRD; cl15445 278197004344 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 278197004345 active pocket/dimerization site; other site 278197004346 active site 278197004347 phosphorylation site [posttranslational modification] 278197004348 Domain of unknown function (DUF956); Region: DUF956; cl01917 278197004349 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 278197004350 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 278197004351 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 278197004352 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 278197004353 active pocket/dimerization site; other site 278197004354 active site 278197004355 phosphorylation site [posttranslational modification] 278197004356 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197004357 active site 278197004358 phosphorylation site [posttranslational modification] 278197004359 hypothetical protein; Provisional; Region: PRK04351 278197004360 SprT homologues; Region: SprT; cl01182 278197004361 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 278197004362 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 278197004363 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 278197004364 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 278197004365 RNA binding site [nucleotide binding]; other site 278197004366 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 278197004367 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 278197004368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197004369 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 278197004370 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197004371 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 278197004372 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 278197004373 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 278197004374 homodimer interface [polypeptide binding]; other site 278197004375 NAD binding pocket [chemical binding]; other site 278197004376 ATP binding pocket [chemical binding]; other site 278197004377 Mg binding site [ion binding]; other site 278197004378 active-site loop [active] 278197004379 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 278197004380 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 278197004381 active site 278197004382 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 278197004383 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197004384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197004385 DNA-binding site [nucleotide binding]; DNA binding site 278197004386 UTRA domain; Region: UTRA; cl01230 278197004387 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 278197004388 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 278197004389 active site 278197004390 dimer interface [polypeptide binding]; other site 278197004391 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 278197004392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197004393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278197004394 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278197004395 active site 278197004396 metal binding site [ion binding]; metal-binding site 278197004397 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 278197004398 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278197004399 folate binding site [chemical binding]; other site 278197004400 NADP+ binding site [chemical binding]; other site 278197004401 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 278197004402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278197004403 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 278197004404 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 278197004405 dimer interface [polypeptide binding]; other site 278197004406 putative anticodon binding site; other site 278197004407 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 278197004408 motif 1; other site 278197004409 active site 278197004410 motif 2; other site 278197004411 motif 3; other site 278197004412 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 278197004413 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 278197004414 FMN binding site [chemical binding]; other site 278197004415 active site 278197004416 catalytic residues [active] 278197004417 substrate binding site [chemical binding]; other site 278197004418 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 278197004419 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 278197004420 dimerization interface [polypeptide binding]; other site 278197004421 domain crossover interface; other site 278197004422 redox-dependent activation switch; other site 278197004423 FtsH Extracellular; Region: FtsH_ext; pfam06480 278197004424 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 278197004425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004426 Walker A motif; other site 278197004427 ATP binding site [chemical binding]; other site 278197004428 Walker B motif; other site 278197004429 arginine finger; other site 278197004430 Peptidase family M41; Region: Peptidase_M41; pfam01434 278197004431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197004432 active site 278197004433 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 278197004434 Ligand Binding Site [chemical binding]; other site 278197004435 B3/4 domain; Region: B3_4; cl11458 278197004436 hypothetical protein; Provisional; Region: PRK08582 278197004437 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 278197004438 RNA binding site [nucleotide binding]; other site 278197004439 Septum formation initiator; Region: DivIC; cl11433 278197004440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 278197004441 stage V sporulation protein B; Region: spore_V_B; TIGR02900 278197004442 MatE; Region: MatE; cl10513 278197004443 MatE; Region: MatE; cl10513 278197004444 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 278197004445 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 278197004446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197004447 ATP binding site [chemical binding]; other site 278197004448 putative Mg++ binding site [ion binding]; other site 278197004449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197004450 nucleotide binding region [chemical binding]; other site 278197004451 ATP-binding site [chemical binding]; other site 278197004452 TRCF domain; Region: TRCF; cl04088 278197004453 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 278197004454 putative active site [active] 278197004455 catalytic residue [active] 278197004456 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 278197004457 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 278197004458 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197004459 NAD binding site [chemical binding]; other site 278197004460 dimer interface [polypeptide binding]; other site 278197004461 substrate binding site [chemical binding]; other site 278197004462 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 278197004463 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278197004464 FOG: CBS domain [General function prediction only]; Region: COG0517 278197004465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 278197004466 PemK-like protein; Region: PemK; cl00995 278197004467 alanine racemase; Reviewed; Region: alr; PRK00053 278197004468 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 278197004469 active site 278197004470 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278197004471 dimer interface [polypeptide binding]; other site 278197004472 substrate binding site [chemical binding]; other site 278197004473 catalytic residues [active] 278197004474 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 278197004475 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278197004476 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197004477 ATP binding site [chemical binding]; other site 278197004478 Mg++ binding site [ion binding]; other site 278197004479 motif III; other site 278197004480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197004481 nucleotide binding region [chemical binding]; other site 278197004482 ATP-binding site [chemical binding]; other site 278197004483 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 278197004484 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278197004485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197004486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197004487 Peptidase family M48; Region: Peptidase_M48; cl12018 278197004488 LemA family; Region: LemA; cl00742 278197004489 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 278197004490 active site 278197004491 catalytic site [active] 278197004492 drug efflux system protein MdtG; Provisional; Region: PRK09874 278197004493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004494 putative substrate translocation pore; other site 278197004495 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 278197004496 transcription termination factor Rho; Provisional; Region: rho; PRK09376 278197004497 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 278197004498 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 278197004499 RNA binding site [nucleotide binding]; other site 278197004500 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 278197004501 multimer interface [polypeptide binding]; other site 278197004502 Walker A motif; other site 278197004503 ATP binding site [chemical binding]; other site 278197004504 Walker B motif; other site 278197004505 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 278197004506 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 278197004507 hinge; other site 278197004508 active site 278197004509 CTP synthetase; Validated; Region: pyrG; PRK05380 278197004510 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 278197004511 Catalytic site [active] 278197004512 active site 278197004513 UTP binding site [chemical binding]; other site 278197004514 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 278197004515 active site 278197004516 putative oxyanion hole; other site 278197004517 catalytic triad [active] 278197004518 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 278197004519 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 278197004520 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 278197004521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197004522 Zn2+ binding site [ion binding]; other site 278197004523 Mg2+ binding site [ion binding]; other site 278197004524 sugar phosphate phosphatase; Provisional; Region: PRK10513 278197004525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004526 active site 278197004527 motif I; other site 278197004528 motif II; other site 278197004529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004530 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 278197004531 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197004532 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197004533 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 278197004534 MatE; Region: MatE; cl10513 278197004535 MatE; Region: MatE; cl10513 278197004536 CAAX protease self-immunity; Region: Abi; cl00558 278197004537 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 278197004538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004539 motif II; other site 278197004540 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 278197004541 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 278197004542 peptide binding site [polypeptide binding]; other site 278197004543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197004544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 278197004545 Uncharacterized conserved protein [Function unknown]; Region: COG1284 278197004546 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197004547 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 278197004548 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 278197004549 DltD N-terminal region; Region: DltD_N; pfam04915 278197004550 DltD central region; Region: DltD_M; pfam04918 278197004551 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 278197004552 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278197004553 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 278197004554 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 278197004555 AMP-binding enzyme; Region: AMP-binding; cl15778 278197004556 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278197004557 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 278197004558 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 278197004559 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 278197004560 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 278197004561 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 278197004562 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197004563 DNA binding residues [nucleotide binding] 278197004564 putative dimer interface [polypeptide binding]; other site 278197004565 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197004566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004567 putative substrate translocation pore; other site 278197004568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004569 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 278197004570 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197004571 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 278197004572 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 278197004573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197004574 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278197004575 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278197004576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197004577 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278197004578 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197004579 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197004580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197004581 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 278197004582 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 278197004583 Walker A/P-loop; other site 278197004584 ATP binding site [chemical binding]; other site 278197004585 Q-loop/lid; other site 278197004586 ABC transporter signature motif; other site 278197004587 Walker B; other site 278197004588 D-loop; other site 278197004589 H-loop/switch region; other site 278197004590 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278197004591 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 278197004592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 278197004593 active site 278197004594 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197004595 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197004596 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 278197004597 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 278197004598 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 278197004599 Ligand binding site; other site 278197004600 Putative Catalytic site; other site 278197004601 DXD motif; other site 278197004602 GtrA-like protein; Region: GtrA; cl00971 278197004603 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 278197004604 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 278197004605 nucleotide binding pocket [chemical binding]; other site 278197004606 K-X-D-G motif; other site 278197004607 catalytic site [active] 278197004608 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 278197004609 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 278197004610 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 278197004611 Dimer interface [polypeptide binding]; other site 278197004612 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 278197004613 active site 278197004614 putative catalytic site [active] 278197004615 DNA binding site [nucleotide binding] 278197004616 putative phosphate binding site [ion binding]; other site 278197004617 metal binding site A [ion binding]; metal-binding site 278197004618 AP binding site [nucleotide binding]; other site 278197004619 metal binding site B [ion binding]; metal-binding site 278197004620 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 278197004621 substrate binding site [chemical binding]; other site 278197004622 Membrane transport protein; Region: Mem_trans; cl09117 278197004623 malate dehydrogenase; Provisional; Region: PRK13529 278197004624 Malic enzyme, N-terminal domain; Region: malic; pfam00390 278197004625 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 278197004626 NAD(P) binding site [chemical binding]; other site 278197004627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197004628 Helix-turn-helix domains; Region: HTH; cl00088 278197004629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197004630 dimerization interface [polypeptide binding]; other site 278197004631 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197004632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197004633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197004634 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 278197004635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197004636 active site 278197004637 catalytic tetrad [active] 278197004638 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 278197004639 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197004640 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 278197004641 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 278197004642 Cl- selectivity filter; other site 278197004643 Cl- binding residues [ion binding]; other site 278197004644 pore gating glutamate residue; other site 278197004645 dimer interface [polypeptide binding]; other site 278197004646 H+/Cl- coupling transport residue; other site 278197004647 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278197004648 glycerol kinase; Provisional; Region: glpK; PRK00047 278197004649 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 278197004650 N- and C-terminal domain interface [polypeptide binding]; other site 278197004651 active site 278197004652 MgATP binding site [chemical binding]; other site 278197004653 catalytic site [active] 278197004654 metal binding site [ion binding]; metal-binding site 278197004655 glycerol binding site [chemical binding]; other site 278197004656 homotetramer interface [polypeptide binding]; other site 278197004657 homodimer interface [polypeptide binding]; other site 278197004658 FBP binding site [chemical binding]; other site 278197004659 protein IIAGlc interface [polypeptide binding]; other site 278197004660 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 278197004661 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 278197004662 amphipathic channel; other site 278197004663 Asn-Pro-Ala signature motifs; other site 278197004664 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 278197004665 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278197004666 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 278197004667 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 278197004668 Amidinotransferase; Region: Amidinotransf; cl12043 278197004669 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 278197004670 carbamate kinase; Reviewed; Region: PRK12686 278197004671 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 278197004672 putative substrate binding site [chemical binding]; other site 278197004673 nucleotide binding site [chemical binding]; other site 278197004674 nucleotide binding site [chemical binding]; other site 278197004675 homodimer interface [polypeptide binding]; other site 278197004676 ornithine carbamoyltransferase; Provisional; Region: PRK04284 278197004677 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278197004678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197004679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 278197004680 Response regulator receiver domain; Region: Response_reg; pfam00072 278197004681 active site 278197004682 phosphorylation site [posttranslational modification] 278197004683 intermolecular recognition site; other site 278197004684 dimerization interface [polypeptide binding]; other site 278197004685 YcbB domain; Region: YcbB; pfam08664 278197004686 oligoendopeptidase F; Region: pepF; TIGR00181 278197004687 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 278197004688 active site 278197004689 Zn binding site [ion binding]; other site 278197004690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197004692 putative substrate translocation pore; other site 278197004693 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 278197004694 Helix-turn-helix domains; Region: HTH; cl00088 278197004695 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 278197004696 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 278197004697 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 278197004698 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 278197004699 BCCT family transporter; Region: BCCT; cl00569 278197004700 maltose O-acetyltransferase; Provisional; Region: PRK10092 278197004701 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 278197004702 active site 278197004703 substrate binding site [chemical binding]; other site 278197004704 trimer interface [polypeptide binding]; other site 278197004705 CoA binding site [chemical binding]; other site 278197004706 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197004707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197004708 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197004709 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197004710 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 278197004711 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 278197004712 putative dimer interface [polypeptide binding]; other site 278197004713 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 278197004714 active site 278197004715 multimer interface [polypeptide binding]; other site 278197004716 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 278197004717 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197004718 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197004719 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 278197004720 Helix-turn-helix domains; Region: HTH; cl00088 278197004721 EamA-like transporter family; Region: EamA; cl01037 278197004722 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 278197004723 EamA-like transporter family; Region: EamA; cl01037 278197004724 Helix-turn-helix domains; Region: HTH; cl00088 278197004725 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 278197004726 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197004727 Walker A/P-loop; other site 278197004728 ATP binding site [chemical binding]; other site 278197004729 Q-loop/lid; other site 278197004730 ABC transporter signature motif; other site 278197004731 Walker B; other site 278197004732 D-loop; other site 278197004733 H-loop/switch region; other site 278197004734 ABC transporter; Region: ABC_tran_2; pfam12848 278197004735 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278197004736 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197004737 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 278197004738 Walker A/P-loop; other site 278197004739 ATP binding site [chemical binding]; other site 278197004740 Q-loop/lid; other site 278197004741 ABC transporter signature motif; other site 278197004742 Walker B; other site 278197004743 D-loop; other site 278197004744 H-loop/switch region; other site 278197004745 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 278197004746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197004747 FtsX-like permease family; Region: FtsX; cl15850 278197004748 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 278197004749 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 278197004750 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197004751 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 278197004752 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197004753 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 278197004754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278197004755 NMT1-like family; Region: NMT1_2; cl15260 278197004756 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 278197004757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197004758 dimer interface [polypeptide binding]; other site 278197004759 conserved gate region; other site 278197004760 putative PBP binding loops; other site 278197004761 ABC-ATPase subunit interface; other site 278197004762 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 278197004763 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 278197004764 Walker A/P-loop; other site 278197004765 ATP binding site [chemical binding]; other site 278197004766 Q-loop/lid; other site 278197004767 ABC transporter signature motif; other site 278197004768 Walker B; other site 278197004769 D-loop; other site 278197004770 H-loop/switch region; other site 278197004771 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 278197004772 peptidase T; Region: peptidase-T; TIGR01882 278197004773 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 278197004774 metal binding site [ion binding]; metal-binding site 278197004775 dimer interface [polypeptide binding]; other site 278197004776 putative oxidoreductase; Provisional; Region: PRK10206 278197004777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197004778 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 278197004779 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278197004780 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278197004781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197004782 Walker A/P-loop; other site 278197004783 ATP binding site [chemical binding]; other site 278197004784 Q-loop/lid; other site 278197004785 ABC transporter signature motif; other site 278197004786 Walker B; other site 278197004787 D-loop; other site 278197004788 H-loop/switch region; other site 278197004789 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197004790 Helix-turn-helix domains; Region: HTH; cl00088 278197004791 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 278197004792 DAK2 domain; Region: Dak2; cl03685 278197004793 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 278197004794 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 278197004795 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278197004796 synthetase active site [active] 278197004797 NTP binding site [chemical binding]; other site 278197004798 metal binding site [ion binding]; metal-binding site 278197004799 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197004800 Asp23 family; Region: Asp23; cl00574 278197004801 Asp23 family; Region: Asp23; cl00574 278197004802 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 278197004803 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197004804 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 278197004805 active site 278197004806 dimer interface [polypeptide binding]; other site 278197004807 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 278197004808 active site 278197004809 catalytic residues [active] 278197004810 metal binding site [ion binding]; metal-binding site 278197004811 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 278197004812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004813 Coenzyme A binding pocket [chemical binding]; other site 278197004814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197004815 Helix-turn-helix domains; Region: HTH; cl00088 278197004816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197004817 Helix-turn-helix domains; Region: HTH; cl00088 278197004818 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 278197004819 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278197004820 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 278197004821 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 278197004822 Walker A/P-loop; other site 278197004823 ATP binding site [chemical binding]; other site 278197004824 Q-loop/lid; other site 278197004825 ABC transporter signature motif; other site 278197004826 Walker B; other site 278197004827 D-loop; other site 278197004828 H-loop/switch region; other site 278197004829 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278197004830 Cupin domain; Region: Cupin_2; cl09118 278197004831 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278197004832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197004833 Helix-turn-helix domains; Region: HTH; cl00088 278197004834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197004835 dimerization interface [polypeptide binding]; other site 278197004836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197004837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004838 Coenzyme A binding pocket [chemical binding]; other site 278197004839 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 278197004840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004841 putative substrate translocation pore; other site 278197004842 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 278197004843 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 278197004844 Ligand Binding Site [chemical binding]; other site 278197004845 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 278197004846 amphipathic channel; other site 278197004847 Asn-Pro-Ala signature motifs; other site 278197004848 Protein of unknown function DUF111; Region: DUF111; cl03398 278197004849 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 278197004850 AIR carboxylase; Region: AIRC; cl00310 278197004851 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 278197004852 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278197004853 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 278197004854 Helix-turn-helix domains; Region: HTH; cl00088 278197004855 High-affinity nickel-transport protein; Region: NicO; cl00964 278197004856 Sugar transport protein; Region: Sugar_transport; pfam06800 278197004857 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 278197004858 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278197004859 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 278197004860 substrate binding site [chemical binding]; other site 278197004861 dimer interface [polypeptide binding]; other site 278197004862 ATP binding site [chemical binding]; other site 278197004863 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197004864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197004865 DNA binding site [nucleotide binding] 278197004866 domain linker motif; other site 278197004867 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 278197004868 dimerization interface [polypeptide binding]; other site 278197004869 ligand binding site [chemical binding]; other site 278197004870 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 278197004871 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 278197004872 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 278197004873 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 278197004874 DXD motif; other site 278197004875 PilZ domain; Region: PilZ; cl01260 278197004876 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 278197004877 Ligand binding site; other site 278197004878 Putative Catalytic site; other site 278197004879 DXD motif; other site 278197004880 GtrA-like protein; Region: GtrA; cl00971 278197004881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004882 catalytic core [active] 278197004883 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 278197004884 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 278197004885 catalytic residues [active] 278197004886 catalytic nucleophile [active] 278197004887 Presynaptic Site I dimer interface [polypeptide binding]; other site 278197004888 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 278197004889 Synaptic Flat tetramer interface [polypeptide binding]; other site 278197004890 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 278197004891 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197004892 NAD(P) binding site [chemical binding]; other site 278197004893 putative active site [active] 278197004894 B3/4 domain; Region: B3_4; cl11458 278197004895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004896 catalytic core [active] 278197004897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004898 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278197004899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197004900 S-adenosylmethionine binding site [chemical binding]; other site 278197004901 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 278197004902 AzlC protein; Region: AzlC; cl00570 278197004903 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 278197004904 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197004905 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 278197004906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197004907 dimer interface [polypeptide binding]; other site 278197004908 phosphorylation site [posttranslational modification] 278197004909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197004910 ATP binding site [chemical binding]; other site 278197004911 Mg2+ binding site [ion binding]; other site 278197004912 G-X-G motif; other site 278197004913 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197004914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197004915 active site 278197004916 phosphorylation site [posttranslational modification] 278197004917 intermolecular recognition site; other site 278197004918 dimerization interface [polypeptide binding]; other site 278197004919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197004920 DNA binding site [nucleotide binding] 278197004921 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 278197004922 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 278197004923 DNA binding site [nucleotide binding] 278197004924 active site 278197004925 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 278197004926 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 278197004927 active site 278197004928 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 278197004929 GTP-binding protein YchF; Reviewed; Region: PRK09601 278197004930 YchF GTPase; Region: YchF; cd01900 278197004931 G1 box; other site 278197004932 GTP/Mg2+ binding site [chemical binding]; other site 278197004933 Switch I region; other site 278197004934 G2 box; other site 278197004935 Switch II region; other site 278197004936 G3 box; other site 278197004937 G4 box; other site 278197004938 G5 box; other site 278197004939 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 278197004940 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 278197004941 ParB-like partition proteins; Region: parB_part; TIGR00180 278197004942 ParB-like nuclease domain; Region: ParBc; cl02129 278197004943 KorB domain; Region: KorB; pfam08535 278197004944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 278197004945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004946 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 278197004947 Coenzyme A binding pocket [chemical binding]; other site 278197004948 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 278197004949 active site 278197004950 tetramer interface [polypeptide binding]; other site 278197004951 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 278197004952 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 278197004953 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 278197004954 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 278197004955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197004956 DEAD_2; Region: DEAD_2; pfam06733 278197004957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197004958 NlpC/P60 family; Region: NLPC_P60; cl11438 278197004959 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278197004960 Protein of unknown function (DUF972); Region: DUF972; pfam06156 278197004961 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 278197004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004963 putative substrate translocation pore; other site 278197004964 TRAM domain; Region: TRAM; cl01282 278197004965 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 278197004966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 278197004967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278197004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197004969 active site 278197004970 phosphorylation site [posttranslational modification] 278197004971 intermolecular recognition site; other site 278197004972 dimerization interface [polypeptide binding]; other site 278197004973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278197004974 DNA binding residues [nucleotide binding] 278197004975 dimerization interface [polypeptide binding]; other site 278197004976 Histidine kinase; Region: HisKA_3; pfam07730 278197004977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278197004978 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 278197004979 Rhomboid family; Region: Rhomboid; cl11446 278197004980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278197004981 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 278197004982 Walker A/P-loop; other site 278197004983 ATP binding site [chemical binding]; other site 278197004984 Q-loop/lid; other site 278197004985 ABC transporter signature motif; other site 278197004986 Walker B; other site 278197004987 D-loop; other site 278197004988 H-loop/switch region; other site 278197004989 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 278197004990 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278197004991 OpgC protein; Region: OpgC_C; cl00792 278197004992 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278197004993 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 278197004994 catalytic triad [active] 278197004995 catalytic triad [active] 278197004996 oxyanion hole [active] 278197004997 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 278197004998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197004999 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 278197005000 Walker A/P-loop; other site 278197005001 ATP binding site [chemical binding]; other site 278197005002 Q-loop/lid; other site 278197005003 ABC transporter signature motif; other site 278197005004 Walker B; other site 278197005005 D-loop; other site 278197005006 H-loop/switch region; other site 278197005007 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 278197005008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197005009 catalytic residue [active] 278197005010 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 278197005011 endonuclease III; Region: ENDO3c; smart00478 278197005012 minor groove reading motif; other site 278197005013 helix-hairpin-helix signature motif; other site 278197005014 substrate binding pocket [chemical binding]; other site 278197005015 active site 278197005016 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197005017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278197005018 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 278197005019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197005020 Helix-turn-helix domains; Region: HTH; cl00088 278197005021 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 278197005022 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 278197005023 active site 278197005024 dimer interface [polypeptide binding]; other site 278197005025 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 278197005026 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 278197005027 dimer interface [polypeptide binding]; other site 278197005028 active site 278197005029 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 278197005030 putative active site [active] 278197005031 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197005032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197005033 DNA-binding site [nucleotide binding]; DNA binding site 278197005034 UTRA domain; Region: UTRA; cl01230 278197005035 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 278197005036 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 278197005037 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197005038 active site 278197005039 phosphorylation site [posttranslational modification] 278197005040 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 278197005041 active pocket/dimerization site; other site 278197005042 active site 278197005043 phosphorylation site [posttranslational modification] 278197005044 Domain of unknown function (DUF303); Region: DUF303; pfam03629 278197005045 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 278197005046 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 278197005047 active site 278197005048 catalytic residues [active] 278197005049 QueT transporter; Region: QueT; cl01932 278197005050 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 278197005051 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 278197005052 putative NAD(P) binding site [chemical binding]; other site 278197005053 dimer interface [polypeptide binding]; other site 278197005054 Predicted transcriptional regulator [Transcription]; Region: COG1959 278197005055 Helix-turn-helix domains; Region: HTH; cl00088 278197005056 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 278197005057 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 278197005058 NADP binding site [chemical binding]; other site 278197005059 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 278197005060 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 278197005061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197005062 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197005063 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197005064 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 278197005065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 278197005066 E3 interaction surface; other site 278197005067 lipoyl attachment site [posttranslational modification]; other site 278197005068 e3 binding domain; Region: E3_binding; pfam02817 278197005069 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 278197005070 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 278197005071 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 278197005072 alpha subunit interface [polypeptide binding]; other site 278197005073 TPP binding site [chemical binding]; other site 278197005074 heterodimer interface [polypeptide binding]; other site 278197005075 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 278197005076 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 278197005077 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 278197005078 TPP-binding site [chemical binding]; other site 278197005079 tetramer interface [polypeptide binding]; other site 278197005080 heterodimer interface [polypeptide binding]; other site 278197005081 phosphorylation loop region [posttranslational modification] 278197005082 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 278197005083 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 278197005084 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 278197005085 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197005086 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197005087 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197005088 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197005089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197005090 DNA-binding site [nucleotide binding]; DNA binding site 278197005091 UTRA domain; Region: UTRA; cl01230 278197005092 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 278197005093 putative FMN binding site [chemical binding]; other site 278197005094 Predicted membrane protein [Function unknown]; Region: COG1511 278197005095 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 278197005096 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 278197005097 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 278197005098 Predicted membrane protein [Function unknown]; Region: COG1511 278197005099 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 278197005100 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278197005101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278197005102 dimerization interface [polypeptide binding]; other site 278197005103 putative DNA binding site [nucleotide binding]; other site 278197005104 putative Zn2+ binding site [ion binding]; other site 278197005105 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 278197005106 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278197005107 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 278197005108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197005109 S-adenosylmethionine binding site [chemical binding]; other site 278197005110 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 278197005111 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 278197005112 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 278197005113 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 278197005114 dimanganese center [ion binding]; other site 278197005115 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197005116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278197005117 metal binding site [ion binding]; metal-binding site 278197005118 active site 278197005119 I-site; other site 278197005120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197005121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197005122 putative substrate translocation pore; other site 278197005123 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 278197005124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 278197005125 protein binding site [polypeptide binding]; other site 278197005126 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278197005127 YycH protein; Region: YycI; cl02015 278197005128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 278197005129 YycH protein; Region: YycH; pfam07435 278197005130 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278197005131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 278197005132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278197005133 dimerization interface [polypeptide binding]; other site 278197005134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 278197005135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197005136 dimer interface [polypeptide binding]; other site 278197005137 phosphorylation site [posttranslational modification] 278197005138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197005139 ATP binding site [chemical binding]; other site 278197005140 Mg2+ binding site [ion binding]; other site 278197005141 G-X-G motif; other site 278197005142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197005143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197005144 active site 278197005145 phosphorylation site [posttranslational modification] 278197005146 intermolecular recognition site; other site 278197005147 dimerization interface [polypeptide binding]; other site 278197005148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197005149 DNA binding site [nucleotide binding] 278197005150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197005151 Helix-turn-helix domains; Region: HTH; cl00088 278197005152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197005153 dimerization interface [polypeptide binding]; other site 278197005154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197005155 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197005156 NAD(P) binding site [chemical binding]; other site 278197005157 active site 278197005158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197005159 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197005160 putative substrate translocation pore; other site 278197005161 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278197005162 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197005163 active site 278197005164 motif I; other site 278197005165 motif II; other site 278197005166 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 278197005167 HPr interaction site; other site 278197005168 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197005169 active site 278197005170 phosphorylation site [posttranslational modification] 278197005171 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 278197005172 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197005173 active site turn [active] 278197005174 phosphorylation site [posttranslational modification] 278197005175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197005176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197005177 DNA-binding site [nucleotide binding]; DNA binding site 278197005178 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 278197005179 UTRA domain; Region: UTRA; cl01230 278197005180 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 278197005181 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 278197005182 Ca binding site [ion binding]; other site 278197005183 active site 278197005184 catalytic site [active] 278197005185 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 278197005186 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 278197005187 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 278197005188 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 278197005189 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 278197005190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197005191 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 278197005192 Walker A/P-loop; other site 278197005193 ATP binding site [chemical binding]; other site 278197005194 Q-loop/lid; other site 278197005195 ABC transporter signature motif; other site 278197005196 Walker B; other site 278197005197 D-loop; other site 278197005198 H-loop/switch region; other site 278197005199 FtsX-like permease family; Region: FtsX; cl15850 278197005200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197005201 Helix-turn-helix domains; Region: HTH; cl00088 278197005202 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 278197005203 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278197005204 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197005205 active site turn [active] 278197005206 phosphorylation site [posttranslational modification] 278197005207 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 278197005208 HPr interaction site; other site 278197005209 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197005210 active site 278197005211 phosphorylation site [posttranslational modification] 278197005212 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 278197005213 homopentamer interface [polypeptide binding]; other site 278197005214 active site 278197005215 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 278197005216 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 278197005217 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 278197005218 dimerization interface [polypeptide binding]; other site 278197005219 active site 278197005220 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 278197005221 Lumazine binding domain; Region: Lum_binding; pfam00677 278197005222 Lumazine binding domain; Region: Lum_binding; pfam00677 278197005223 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 278197005224 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 278197005225 catalytic motif [active] 278197005226 Zn binding site [ion binding]; other site 278197005227 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278197005228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278197005229 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 278197005230 NAD(P) binding site [chemical binding]; other site 278197005231 catalytic residues [active] 278197005232 Acetokinase family; Region: Acetate_kinase; cl01029 278197005233 propionate/acetate kinase; Provisional; Region: PRK12379 278197005234 Helix-turn-helix domains; Region: HTH; cl00088 278197005235 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 278197005236 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 278197005237 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 278197005238 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 278197005239 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 278197005240 putative dimer interface [polypeptide binding]; other site 278197005241 catalytic triad [active] 278197005242 Protein of unknown function (DUF454); Region: DUF454; cl01063 278197005243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197005244 non-specific DNA binding site [nucleotide binding]; other site 278197005245 salt bridge; other site 278197005246 sequence-specific DNA binding site [nucleotide binding]; other site 278197005247 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 278197005248 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 278197005249 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 278197005250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278197005251 Family description; Region: UvrD_C_2; cl15862 278197005252 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 278197005253 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 278197005254 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 278197005255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197005256 NAD(P) binding site [chemical binding]; other site 278197005257 active site 278197005258 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 278197005259 xanthine permease; Region: pbuX; TIGR03173 278197005260 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 278197005261 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 278197005262 active site 278197005263 catalytic triad [active] 278197005264 oxyanion hole [active] 278197005265 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 278197005266 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 278197005267 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 278197005268 putative active site [active] 278197005269 catalytic site [active] 278197005270 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 278197005271 putative active site [active] 278197005272 catalytic site [active] 278197005273 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 278197005274 nucleotide binding site/active site [active] 278197005275 HIT family signature motif; other site 278197005276 catalytic residue [active] 278197005277 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 278197005278 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278197005279 Catalytic site [active] 278197005280 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278197005281 Protein of unknown function (DUF328); Region: DUF328; cl01143 278197005282 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 278197005283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197005284 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 278197005285 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 278197005286 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 278197005287 trmE is a tRNA modification GTPase; Region: trmE; cd04164 278197005288 G1 box; other site 278197005289 GTP/Mg2+ binding site [chemical binding]; other site 278197005290 Switch I region; other site 278197005291 G2 box; other site 278197005292 Switch II region; other site 278197005293 G3 box; other site 278197005294 G4 box; other site 278197005295 G5 box; other site 278197005296 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 278197005297 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 278197005298 Ribonuclease P; Region: Ribonuclease_P; cl00457 278197005299 Ribosomal protein L34; Region: Ribosomal_L34; cl00370