-- dump date 20120504_154748 -- class Genbank::misc_feature -- table misc_feature_note -- id note 370438000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 370438000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 370438000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438000004 Walker A motif; other site 370438000005 ATP binding site [chemical binding]; other site 370438000006 Walker B motif; other site 370438000007 arginine finger; other site 370438000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 370438000009 DnaA box-binding interface [nucleotide binding]; other site 370438000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 370438000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 370438000012 putative DNA binding surface [nucleotide binding]; other site 370438000013 dimer interface [polypeptide binding]; other site 370438000014 beta-clamp/clamp loader binding surface; other site 370438000015 beta-clamp/translesion DNA polymerase binding surface; other site 370438000016 recombination protein F; Reviewed; Region: recF; PRK00064 370438000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 370438000018 Walker A/P-loop; other site 370438000019 ATP binding site [chemical binding]; other site 370438000020 Q-loop/lid; other site 370438000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000022 ABC transporter signature motif; other site 370438000023 Walker B; other site 370438000024 D-loop; other site 370438000025 H-loop/switch region; other site 370438000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 370438000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000028 Mg2+ binding site [ion binding]; other site 370438000029 G-X-G motif; other site 370438000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 370438000031 anchoring element; other site 370438000032 dimer interface [polypeptide binding]; other site 370438000033 ATP binding site [chemical binding]; other site 370438000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 370438000035 active site 370438000036 putative metal-binding site [ion binding]; other site 370438000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 370438000038 CHASE3 domain; Region: CHASE3; cl05000 370438000039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438000040 dimerization interface [polypeptide binding]; other site 370438000041 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 370438000042 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438000043 dimer interface [polypeptide binding]; other site 370438000044 putative CheW interface [polypeptide binding]; other site 370438000045 DNA gyrase subunit A; Validated; Region: PRK05560 370438000046 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 370438000047 CAP-like domain; other site 370438000048 active site 370438000049 primary dimer interface [polypeptide binding]; other site 370438000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370438000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370438000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370438000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370438000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370438000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370438000056 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 370438000057 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 370438000058 active site 370438000059 multimer interface [polypeptide binding]; other site 370438000060 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 370438000061 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 370438000062 predicted active site [active] 370438000063 catalytic triad [active] 370438000064 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 370438000065 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 370438000066 homodimer interface [polypeptide binding]; other site 370438000067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438000068 catalytic residue [active] 370438000069 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 370438000070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000071 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 370438000072 putative L-serine binding site [chemical binding]; other site 370438000073 seryl-tRNA synthetase; Provisional; Region: PRK05431 370438000074 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 370438000075 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 370438000076 dimer interface [polypeptide binding]; other site 370438000077 active site 370438000078 motif 1; other site 370438000079 motif 2; other site 370438000080 motif 3; other site 370438000081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 370438000082 active site 370438000083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438000084 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 370438000085 FAD binding site [chemical binding]; other site 370438000086 homotetramer interface [polypeptide binding]; other site 370438000087 substrate binding pocket [chemical binding]; other site 370438000088 catalytic base [active] 370438000089 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 370438000090 Ligand binding site [chemical binding]; other site 370438000091 Electron transfer flavoprotein domain; Region: ETF; pfam01012 370438000092 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 370438000093 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 370438000094 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 370438000095 oxidoreductase; Provisional; Region: PRK10015 370438000096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000097 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 370438000098 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438000099 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 370438000100 Helix-turn-helix domains; Region: HTH; cl00088 370438000101 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 370438000102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438000103 active site 370438000104 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 370438000105 active site 370438000106 NTP binding site [chemical binding]; other site 370438000107 metal binding triad [ion binding]; metal-binding site 370438000108 antibiotic binding site [chemical binding]; other site 370438000109 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 370438000110 nucleoside/Zn binding site; other site 370438000111 dimer interface [polypeptide binding]; other site 370438000112 catalytic motif [active] 370438000113 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 370438000114 dimer interface [polypeptide binding]; other site 370438000115 [2Fe-2S] cluster binding site [ion binding]; other site 370438000116 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 370438000117 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 370438000118 Putative Fe-S cluster; Region: FeS; pfam04060 370438000119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438000120 PAS domain; Region: PAS_9; pfam13426 370438000121 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 370438000122 Transcriptional regulator [Transcription]; Region: IclR; COG1414 370438000123 Helix-turn-helix domains; Region: HTH; cl00088 370438000124 Bacterial transcriptional regulator; Region: IclR; pfam01614 370438000125 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 370438000126 active site 370438000127 catalytic triad [active] 370438000128 dimer interface [polypeptide binding]; other site 370438000129 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 370438000130 synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299 370438000131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438000132 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438000133 YwpF-like protein; Region: YwpF; pfam14183 370438000134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438000136 active site 370438000137 phosphorylation site [posttranslational modification] 370438000138 intermolecular recognition site; other site 370438000139 dimerization interface [polypeptide binding]; other site 370438000140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438000141 DNA binding site [nucleotide binding] 370438000142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438000143 dimerization interface [polypeptide binding]; other site 370438000144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438000145 dimer interface [polypeptide binding]; other site 370438000146 phosphorylation site [posttranslational modification] 370438000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000148 ATP binding site [chemical binding]; other site 370438000149 Mg2+ binding site [ion binding]; other site 370438000150 G-X-G motif; other site 370438000151 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 370438000152 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 370438000153 E3 interaction surface; other site 370438000154 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438000155 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370438000156 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370438000157 Walker A/P-loop; other site 370438000158 ATP binding site [chemical binding]; other site 370438000159 Q-loop/lid; other site 370438000160 ABC transporter signature motif; other site 370438000161 Walker B; other site 370438000162 D-loop; other site 370438000163 H-loop/switch region; other site 370438000164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370438000165 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 370438000166 FtsX-like permease family; Region: FtsX; cl15850 370438000167 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 370438000168 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 370438000169 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 370438000170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438000171 active site 370438000172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438000173 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 370438000174 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 370438000175 metal binding site 2 [ion binding]; metal-binding site 370438000176 putative DNA binding helix; other site 370438000177 metal binding site 1 [ion binding]; metal-binding site 370438000178 dimer interface [polypeptide binding]; other site 370438000179 structural Zn2+ binding site [ion binding]; other site 370438000180 Rubredoxin [Energy production and conversion]; Region: COG1773 370438000181 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 370438000182 iron binding site [ion binding]; other site 370438000183 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 370438000184 diiron binding motif [ion binding]; other site 370438000185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438000186 dimer interface [polypeptide binding]; other site 370438000187 phosphorylation site [posttranslational modification] 370438000188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000189 ATP binding site [chemical binding]; other site 370438000190 Mg2+ binding site [ion binding]; other site 370438000191 G-X-G motif; other site 370438000192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438000193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438000194 active site 370438000195 phosphorylation site [posttranslational modification] 370438000196 intermolecular recognition site; other site 370438000197 dimerization interface [polypeptide binding]; other site 370438000198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438000199 DNA binding site [nucleotide binding] 370438000200 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 370438000201 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 370438000202 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370438000203 glutamate dehydrogenase; Provisional; Region: PRK09414 370438000204 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 370438000205 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 370438000206 NAD(P) binding site [chemical binding]; other site 370438000207 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 370438000208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000209 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 370438000210 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 370438000211 recombination protein RecR; Reviewed; Region: recR; PRK00076 370438000212 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 370438000213 RecR protein; Region: RecR; pfam02132 370438000214 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 370438000215 putative active site [active] 370438000216 putative metal-binding site [ion binding]; other site 370438000217 tetramer interface [polypeptide binding]; other site 370438000218 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 370438000219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000220 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 370438000221 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 370438000222 dimer interface [polypeptide binding]; other site 370438000223 PYR/PP interface [polypeptide binding]; other site 370438000224 TPP binding site [chemical binding]; other site 370438000225 substrate binding site [chemical binding]; other site 370438000226 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 370438000227 TPP-binding site [chemical binding]; other site 370438000228 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 370438000229 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438000230 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 370438000231 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 370438000232 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 370438000233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370438000234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370438000235 catalytic residue [active] 370438000236 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 370438000237 thymidylate kinase; Validated; Region: tmk; PRK00698 370438000238 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 370438000239 TMP-binding site; other site 370438000240 ATP-binding site [chemical binding]; other site 370438000241 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 370438000242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000243 DNA polymerase III subunit delta'; Validated; Region: PRK07940 370438000244 PSP1 C-terminal conserved region; Region: PSP1; cl00770 370438000245 Protein of unknown function (DUF972); Region: DUF972; pfam06156 370438000246 Predicted methyltransferases [General function prediction only]; Region: COG0313 370438000247 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438000248 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438000249 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 370438000250 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 370438000251 active site 370438000252 HIGH motif; other site 370438000253 KMSKS motif; other site 370438000254 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 370438000255 tRNA binding surface [nucleotide binding]; other site 370438000256 anticodon binding site; other site 370438000257 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 370438000258 active site 370438000259 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 370438000260 homodimer interface [polypeptide binding]; other site 370438000261 Walker A motif; other site 370438000262 ATP binding site [chemical binding]; other site 370438000263 hydroxycobalamin binding site [chemical binding]; other site 370438000264 Walker B motif; other site 370438000265 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 370438000266 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 370438000267 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 370438000268 Walker A/P-loop; other site 370438000269 ATP binding site [chemical binding]; other site 370438000270 Q-loop/lid; other site 370438000271 ABC transporter signature motif; other site 370438000272 Walker B; other site 370438000273 D-loop; other site 370438000274 H-loop/switch region; other site 370438000275 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 370438000276 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 370438000277 Walker A/P-loop; other site 370438000278 ATP binding site [chemical binding]; other site 370438000279 Q-loop/lid; other site 370438000280 ABC transporter signature motif; other site 370438000281 Walker B; other site 370438000282 D-loop; other site 370438000283 H-loop/switch region; other site 370438000284 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 370438000285 TM-ABC transporter signature motif; other site 370438000286 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 370438000287 TM-ABC transporter signature motif; other site 370438000288 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 370438000289 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 370438000290 putative ligand binding site [chemical binding]; other site 370438000291 Domain of unknown function (DUF348); Region: DUF348; pfam03990 370438000292 Domain of unknown function (DUF348); Region: DUF348; pfam03990 370438000293 G5 domain; Region: G5; pfam07501 370438000294 3D domain; Region: 3D; cl01439 370438000295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000296 Protein of unknown function (DUF458); Region: DUF458; cl00861 370438000297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 370438000298 active site 370438000299 YabG peptidase U57; Region: Peptidase_U57; cl05250 370438000300 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 370438000301 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 370438000302 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 370438000303 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 370438000304 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 370438000305 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438000306 putative peptidoglycan binding site; other site 370438000307 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 370438000308 Protein of unknown function, DUF606; Region: DUF606; cl01273 370438000309 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 370438000310 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 370438000311 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438000312 putative peptidoglycan binding site; other site 370438000313 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 370438000314 Transcriptional regulators [Transcription]; Region: GntR; COG1802 370438000315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370438000316 DNA-binding site [nucleotide binding]; DNA binding site 370438000317 FCD domain; Region: FCD; cl11656 370438000318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438000319 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 370438000320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370438000321 Coenzyme A binding pocket [chemical binding]; other site 370438000322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438000323 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 370438000324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438000325 dimer interface [polypeptide binding]; other site 370438000326 phosphorylation site [posttranslational modification] 370438000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000328 ATP binding site [chemical binding]; other site 370438000329 Mg2+ binding site [ion binding]; other site 370438000330 G-X-G motif; other site 370438000331 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 370438000332 threonine dehydratase; Provisional; Region: PRK08198 370438000333 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 370438000334 tetramer interface [polypeptide binding]; other site 370438000335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438000336 catalytic residue [active] 370438000337 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 370438000338 Region: SpoVG; cl00915 370438000339 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 370438000340 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 370438000341 Substrate binding site; other site 370438000342 Mg++ binding site; other site 370438000343 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 370438000344 active site 370438000345 substrate binding site [chemical binding]; other site 370438000346 CoA binding site [chemical binding]; other site 370438000347 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 370438000348 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 370438000349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438000350 active site 370438000351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438000352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 370438000353 putative substrate translocation pore; other site 370438000354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438000355 H+ Antiporter protein; Region: 2A0121; TIGR00900 370438000356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438000357 putative substrate translocation pore; other site 370438000358 PilZ domain; Region: PilZ; cl01260 370438000359 heat shock protein 90; Provisional; Region: PRK05218 370438000360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000361 ATP binding site [chemical binding]; other site 370438000362 Mg2+ binding site [ion binding]; other site 370438000363 G-X-G motif; other site 370438000364 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 370438000365 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370438000366 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 370438000367 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 370438000368 5S rRNA interface [nucleotide binding]; other site 370438000369 CTC domain interface [polypeptide binding]; other site 370438000370 L16 interface [polypeptide binding]; other site 370438000371 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 370438000372 putative active site [active] 370438000373 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 370438000374 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 370438000375 DEAD-like helicases superfamily; Region: DEXDc; smart00487 370438000376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438000377 ATP binding site [chemical binding]; other site 370438000378 putative Mg++ binding site [ion binding]; other site 370438000379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438000380 nucleotide binding region [chemical binding]; other site 370438000381 ATP-binding site [chemical binding]; other site 370438000382 TRCF domain; Region: TRCF; cl04088 370438000383 SurA N-terminal domain; Region: SurA_N_3; cl07813 370438000384 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 370438000385 PPIC-type PPIASE domain; Region: Rotamase; cl08278 370438000386 stage V sporulation protein T; Region: spore_V_T; TIGR02851 370438000387 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438000388 GAF domain; Region: GAF; cl15785 370438000389 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 370438000390 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438000391 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 370438000392 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 370438000393 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 370438000394 IHF dimer interface [polypeptide binding]; other site 370438000395 IHF - DNA interface [nucleotide binding]; other site 370438000396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370438000397 RNA binding surface [nucleotide binding]; other site 370438000398 Stage II sporulation protein; Region: SpoIID; pfam08486 370438000399 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 370438000400 YabP family; Region: YabP; cl06766 370438000401 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 370438000402 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 370438000403 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 370438000404 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 370438000405 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 370438000406 Probable Catalytic site; other site 370438000407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438000408 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 370438000409 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 370438000410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438000411 FeS/SAM binding site; other site 370438000412 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 370438000413 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 370438000414 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 370438000415 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 370438000416 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 370438000417 active site residue [active] 370438000418 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 370438000419 active site residue [active] 370438000420 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 370438000421 active site 370438000422 NTP binding site [chemical binding]; other site 370438000423 metal binding triad [ion binding]; metal-binding site 370438000424 HEPN domain; Region: HEPN; cl00824 370438000425 AAA domain; Region: AAA_21; pfam13304 370438000426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000427 ABC transporter signature motif; other site 370438000428 Walker B; other site 370438000429 D-loop; other site 370438000430 H-loop/switch region; other site 370438000431 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 370438000432 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 370438000433 Protein kinase domain; Region: Pkinase; pfam00069 370438000434 Catalytic domain of Protein Kinases; Region: PKc; cd00180 370438000435 active site 370438000436 ATP binding site [chemical binding]; other site 370438000437 substrate binding site [chemical binding]; other site 370438000438 activation loop (A-loop); other site 370438000439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000440 Predicted ATPase [General function prediction only]; Region: COG3899 370438000441 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 370438000442 GAF domain; Region: GAF; cl15785 370438000443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438000444 dimer interface [polypeptide binding]; other site 370438000445 phosphorylation site [posttranslational modification] 370438000446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000447 ATP binding site [chemical binding]; other site 370438000448 Mg2+ binding site [ion binding]; other site 370438000449 G-X-G motif; other site 370438000450 Response regulator receiver domain; Region: Response_reg; pfam00072 370438000451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438000452 active site 370438000453 phosphorylation site [posttranslational modification] 370438000454 intermolecular recognition site; other site 370438000455 dimerization interface [polypeptide binding]; other site 370438000456 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 370438000457 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438000458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 370438000459 active site 370438000460 phosphorylation site [posttranslational modification] 370438000461 intermolecular recognition site; other site 370438000462 dimerization interface [polypeptide binding]; other site 370438000463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438000464 DNA binding site [nucleotide binding] 370438000465 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438000466 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 370438000467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438000468 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 370438000469 dinuclear metal binding motif [ion binding]; other site 370438000470 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 370438000471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000472 ST7 protein; Region: ST7; pfam04184 370438000473 Transposase [DNA replication, recombination, and repair]; Region: COG5421 370438000474 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 370438000475 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 370438000476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000479 Restriction endonuclease [Defense mechanisms]; Region: COG3587 370438000480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000481 Protein of unknown function DUF262; Region: DUF262; cl14890 370438000482 Uncharacterized conserved protein [Function unknown]; Region: COG4938 370438000483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000484 Walker A/P-loop; other site 370438000485 ATP binding site [chemical binding]; other site 370438000486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000487 Walker B; other site 370438000488 D-loop; other site 370438000489 H-loop/switch region; other site 370438000490 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 370438000491 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 370438000492 NurA domain; Region: NurA; cl09134 370438000493 AAA-like domain; Region: AAA_10; pfam12846 370438000494 Domain of unknown function DUF87; Region: DUF87; pfam01935 370438000495 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370438000496 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 370438000497 catalytic residues [active] 370438000498 catalytic nucleophile [active] 370438000499 Presynaptic Site I dimer interface [polypeptide binding]; other site 370438000500 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 370438000501 Synaptic Flat tetramer interface [polypeptide binding]; other site 370438000502 Synaptic Site I dimer interface [polypeptide binding]; other site 370438000503 DNA binding site [nucleotide binding] 370438000504 Recombinase; Region: Recombinase; pfam07508 370438000505 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370438000506 phosphodiesterase; Provisional; Region: PRK12704 370438000507 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 370438000508 Helix-turn-helix domains; Region: HTH; cl00088 370438000509 RRXRR protein; Region: RRXRR; pfam14239 370438000510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438000511 non-specific DNA binding site [nucleotide binding]; other site 370438000512 salt bridge; other site 370438000513 sequence-specific DNA binding site [nucleotide binding]; other site 370438000514 Helix-turn-helix domains; Region: HTH; cl00088 370438000515 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 370438000516 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438000517 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438000518 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 370438000519 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 370438000520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438000521 active site 370438000522 Int/Topo IB signature motif; other site 370438000523 DNA binding site [nucleotide binding] 370438000524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438000525 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 370438000526 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370438000527 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 370438000528 catalytic residues [active] 370438000529 catalytic nucleophile [active] 370438000530 Recombinase; Region: Recombinase; pfam07508 370438000531 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370438000532 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 370438000533 CotJB protein; Region: CotJB; pfam12652 370438000534 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 370438000535 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 370438000536 S-layer homology domain; Region: SLH; pfam00395 370438000537 S-layer homology domain; Region: SLH; pfam00395 370438000538 Bacterial Ig-like domain; Region: Big_5; cl01012 370438000539 Bacterial Ig-like domain; Region: Big_5; cl01012 370438000540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438000541 Septum formation initiator; Region: DivIC; cl11433 370438000542 hypothetical protein; Provisional; Region: PRK08582 370438000543 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 370438000544 RNA binding site [nucleotide binding]; other site 370438000545 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 370438000546 stage II sporulation protein E; Region: spore_II_E; TIGR02865 370438000547 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 370438000548 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438000549 S-layer homology domain; Region: SLH; pfam00395 370438000550 S-layer homology domain; Region: SLH; pfam00395 370438000551 S-layer homology domain; Region: SLH; pfam00395 370438000552 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 370438000553 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 370438000554 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 370438000555 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 370438000556 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 370438000557 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 370438000558 Ligand Binding Site [chemical binding]; other site 370438000559 TilS substrate binding domain; Region: TilS; pfam09179 370438000560 B3/4 domain; Region: B3_4; cl11458 370438000561 FtsH Extracellular; Region: FtsH_ext; pfam06480 370438000562 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 370438000563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438000564 Walker A motif; other site 370438000565 ATP binding site [chemical binding]; other site 370438000566 Walker B motif; other site 370438000567 arginine finger; other site 370438000568 Peptidase family M41; Region: Peptidase_M41; pfam01434 370438000569 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 370438000570 active site 370438000571 multimer interface [polypeptide binding]; other site 370438000572 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 370438000573 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 370438000574 Potassium binding sites [ion binding]; other site 370438000575 Cesium cation binding sites [ion binding]; other site 370438000576 Cache domain; Region: Cache_1; pfam02743 370438000577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 370438000578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438000579 dimer interface [polypeptide binding]; other site 370438000580 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 370438000581 putative CheW interface [polypeptide binding]; other site 370438000582 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 370438000583 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 370438000584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438000585 dimerization interface [polypeptide binding]; other site 370438000586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438000587 dimer interface [polypeptide binding]; other site 370438000588 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 370438000589 putative CheW interface [polypeptide binding]; other site 370438000590 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 370438000591 dihydropteroate synthase; Region: DHPS; TIGR01496 370438000592 substrate binding pocket [chemical binding]; other site 370438000593 dimer interface [polypeptide binding]; other site 370438000594 inhibitor binding site; inhibition site 370438000595 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 370438000596 homooctamer interface [polypeptide binding]; other site 370438000597 active site 370438000598 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 370438000599 catalytic center binding site [active] 370438000600 ATP binding site [chemical binding]; other site 370438000601 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 370438000602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438000603 FeS/SAM binding site; other site 370438000604 NMT1-like family; Region: NMT1_2; cl15260 370438000605 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 370438000606 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 370438000607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438000608 FeS/SAM binding site; other site 370438000609 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370438000610 Helix-turn-helix domains; Region: HTH; cl00088 370438000611 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 370438000612 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 370438000613 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 370438000614 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 370438000615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438000616 active site 370438000617 DNA binding site [nucleotide binding] 370438000618 Int/Topo IB signature motif; other site 370438000619 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438000620 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438000621 active site 370438000622 DNA binding site [nucleotide binding] 370438000623 Int/Topo IB signature motif; other site 370438000624 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 370438000625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000627 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 370438000628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438000630 Restriction endonuclease [Defense mechanisms]; Region: COG3587 370438000631 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 370438000632 Uncharacterized conserved protein [Function unknown]; Region: COG5495 370438000633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000634 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 370438000635 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 370438000636 oligomerization interface [polypeptide binding]; other site 370438000637 active site 370438000638 metal binding site [ion binding]; metal-binding site 370438000639 pantoate--beta-alanine ligase; Region: panC; TIGR00018 370438000640 Pantoate-beta-alanine ligase; Region: PanC; cd00560 370438000641 active site 370438000642 ATP-binding site [chemical binding]; other site 370438000643 pantoate-binding site; other site 370438000644 HXXH motif; other site 370438000645 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 370438000646 tetramerization interface [polypeptide binding]; other site 370438000647 active site 370438000648 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 370438000649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000650 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 370438000651 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 370438000652 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 370438000653 dimerization interface [polypeptide binding]; other site 370438000654 active site 370438000655 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370438000656 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 370438000657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370438000658 catalytic residue [active] 370438000659 Quinolinate synthetase A protein; Region: NadA; cl00420 370438000660 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 370438000661 metal-binding site [ion binding] 370438000662 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 370438000663 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 370438000664 metal-binding site [ion binding] 370438000665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370438000666 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438000667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438000668 dimerization interface [polypeptide binding]; other site 370438000669 putative DNA binding site [nucleotide binding]; other site 370438000670 putative Zn2+ binding site [ion binding]; other site 370438000671 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 370438000672 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370438000673 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438000674 Helix-turn-helix domains; Region: HTH; cl00088 370438000675 Rrf2 family protein; Region: rrf2_super; TIGR00738 370438000676 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 370438000677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370438000678 substrate binding pocket [chemical binding]; other site 370438000679 membrane-bound complex binding site; other site 370438000680 hinge residues; other site 370438000681 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 370438000682 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 370438000683 Walker A/P-loop; other site 370438000684 ATP binding site [chemical binding]; other site 370438000685 Q-loop/lid; other site 370438000686 ABC transporter signature motif; other site 370438000687 Walker B; other site 370438000688 D-loop; other site 370438000689 H-loop/switch region; other site 370438000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 370438000691 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 370438000692 AAA domain; Region: AAA_18; pfam13238 370438000693 ligand-binding site [chemical binding]; other site 370438000694 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 370438000695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000696 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 370438000697 Ferredoxin [Energy production and conversion]; Region: COG1146 370438000698 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438000699 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 370438000700 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 370438000701 ATP-sulfurylase; Region: ATPS; cd00517 370438000702 active site 370438000703 HXXH motif; other site 370438000704 flexible loop; other site 370438000705 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 370438000706 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 370438000707 4Fe-4S binding domain; Region: Fer4; cl02805 370438000708 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 370438000709 CPxP motif; other site 370438000710 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 370438000711 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 370438000712 ATP binding site [chemical binding]; other site 370438000713 substrate interface [chemical binding]; other site 370438000714 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 370438000715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438000716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438000717 active site 370438000718 phosphorylation site [posttranslational modification] 370438000719 intermolecular recognition site; other site 370438000720 dimerization interface [polypeptide binding]; other site 370438000721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438000722 DNA binding site [nucleotide binding] 370438000723 two-component sensor protein; Provisional; Region: cpxA; PRK09470 370438000724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438000725 dimerization interface [polypeptide binding]; other site 370438000726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438000727 dimer interface [polypeptide binding]; other site 370438000728 phosphorylation site [posttranslational modification] 370438000729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438000730 ATP binding site [chemical binding]; other site 370438000731 Mg2+ binding site [ion binding]; other site 370438000732 G-X-G motif; other site 370438000733 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 370438000734 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 370438000735 dimer interface [polypeptide binding]; other site 370438000736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438000737 catalytic residue [active] 370438000738 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 370438000739 biotin synthase; Provisional; Region: PRK07094 370438000740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438000741 FeS/SAM binding site; other site 370438000742 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 370438000743 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 370438000744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370438000745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438000746 S-adenosylmethionine binding site [chemical binding]; other site 370438000747 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 370438000748 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 370438000749 Ligand Binding Site [chemical binding]; other site 370438000750 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 370438000751 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 370438000752 homodimer interface [polypeptide binding]; other site 370438000753 substrate-cofactor binding pocket; other site 370438000754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438000755 catalytic residue [active] 370438000756 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 370438000757 Helix-turn-helix domains; Region: HTH; cl00088 370438000758 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 370438000759 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370438000760 Late competence development protein ComFB; Region: ComFB; pfam10719 370438000761 Type III pantothenate kinase; Region: Pan_kinase; cl09130 370438000762 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 370438000763 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 370438000764 FMN binding site [chemical binding]; other site 370438000765 active site 370438000766 catalytic residues [active] 370438000767 substrate binding site [chemical binding]; other site 370438000768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438000769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000770 NAD(P) binding pocket [chemical binding]; other site 370438000771 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 370438000772 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 370438000773 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 370438000774 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 370438000775 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 370438000776 dimer interface [polypeptide binding]; other site 370438000777 putative anticodon binding site; other site 370438000778 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 370438000779 motif 1; other site 370438000780 active site 370438000781 motif 2; other site 370438000782 motif 3; other site 370438000783 PrcB C-terminal; Region: PrcB_C; pfam14343 370438000784 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438000785 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 370438000786 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 370438000787 Helix-turn-helix domains; Region: HTH; cl00088 370438000788 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 370438000789 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 370438000790 active site 370438000791 FMN binding site [chemical binding]; other site 370438000792 substrate binding site [chemical binding]; other site 370438000793 putative catalytic residue [active] 370438000794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370438000796 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438000797 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438000798 putative acyltransferase; Provisional; Region: PRK05790 370438000799 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 370438000800 dimer interface [polypeptide binding]; other site 370438000801 active site 370438000802 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 370438000803 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 370438000804 putative NAD(P) binding site [chemical binding]; other site 370438000805 catalytic Zn binding site [ion binding]; other site 370438000806 structural Zn binding site [ion binding]; other site 370438000807 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 370438000808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438000809 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 370438000810 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 370438000811 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 370438000812 Putative cyclase; Region: Cyclase; cl00814 370438000813 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 370438000814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 370438000815 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 370438000816 Walker A/P-loop; other site 370438000817 ATP binding site [chemical binding]; other site 370438000818 Q-loop/lid; other site 370438000819 ABC transporter signature motif; other site 370438000820 Walker B; other site 370438000821 D-loop; other site 370438000822 H-loop/switch region; other site 370438000823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370438000824 DNA-binding site [nucleotide binding]; DNA binding site 370438000825 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 370438000826 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 370438000827 UvrB/uvrC motif; Region: UVR; pfam02151 370438000828 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 370438000829 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 370438000830 ADP binding site [chemical binding]; other site 370438000831 phosphagen binding site; other site 370438000832 substrate specificity loop; other site 370438000833 Clp protease ATP binding subunit; Region: clpC; CHL00095 370438000834 Clp amino terminal domain; Region: Clp_N; pfam02861 370438000835 Clp amino terminal domain; Region: Clp_N; pfam02861 370438000836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438000837 Walker A motif; other site 370438000838 ATP binding site [chemical binding]; other site 370438000839 Walker B motif; other site 370438000840 arginine finger; other site 370438000841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438000842 Walker A motif; other site 370438000843 ATP binding site [chemical binding]; other site 370438000844 Walker B motif; other site 370438000845 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370438000846 Transposase IS200 like; Region: Y1_Tnp; cl00848 370438000847 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 370438000848 DnaA box-binding interface [nucleotide binding]; other site 370438000849 DNA repair protein RadA; Provisional; Region: PRK11823 370438000850 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 370438000851 Walker A motif/ATP binding site; other site 370438000852 ATP binding site [chemical binding]; other site 370438000853 Walker B motif; other site 370438000854 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370438000855 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 370438000856 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 370438000857 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 370438000858 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 370438000859 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 370438000860 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 370438000861 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 370438000862 putative active site [active] 370438000863 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 370438000864 substrate binding site; other site 370438000865 dimer interface; other site 370438000866 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 370438000867 homotrimer interaction site [polypeptide binding]; other site 370438000868 zinc binding site [ion binding]; other site 370438000869 CDP-binding sites; other site 370438000870 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 370438000871 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 370438000872 HIGH motif; other site 370438000873 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 370438000874 active site 370438000875 KMSKS motif; other site 370438000876 serine O-acetyltransferase; Region: cysE; TIGR01172 370438000877 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 370438000878 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 370438000879 trimer interface [polypeptide binding]; other site 370438000880 active site 370438000881 substrate binding site [chemical binding]; other site 370438000882 CoA binding site [chemical binding]; other site 370438000883 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 370438000884 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 370438000885 active site 370438000886 HIGH motif; other site 370438000887 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 370438000888 KMSKS motif; other site 370438000889 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 370438000890 tRNA binding surface [nucleotide binding]; other site 370438000891 anticodon binding site; other site 370438000892 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 370438000893 Thymidylate synthase complementing protein; Region: Thy1; cl03630 370438000894 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 370438000895 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 370438000896 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 370438000897 YacP-like NYN domain; Region: NYN_YacP; cl01491 370438000898 RNA polymerase factor sigma-70; Validated; Region: PRK08295 370438000899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438000900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438000901 elongation factor Tu; Reviewed; Region: PRK00049 370438000902 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 370438000903 G1 box; other site 370438000904 GEF interaction site [polypeptide binding]; other site 370438000905 GTP/Mg2+ binding site [chemical binding]; other site 370438000906 Switch I region; other site 370438000907 G2 box; other site 370438000908 G3 box; other site 370438000909 Switch II region; other site 370438000910 G4 box; other site 370438000911 G5 box; other site 370438000912 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 370438000913 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 370438000914 Antibiotic Binding Site [chemical binding]; other site 370438000915 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 370438000916 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 370438000917 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 370438000918 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 370438000919 putative homodimer interface [polypeptide binding]; other site 370438000920 KOW motif; Region: KOW; cl00354 370438000921 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 370438000922 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 370438000923 23S rRNA interface [nucleotide binding]; other site 370438000924 L7/L12 interface [polypeptide binding]; other site 370438000925 putative thiostrepton binding site; other site 370438000926 L25 interface [polypeptide binding]; other site 370438000927 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 370438000928 mRNA/rRNA interface [nucleotide binding]; other site 370438000929 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 370438000930 23S rRNA interface [nucleotide binding]; other site 370438000931 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 370438000932 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 370438000933 peripheral dimer interface [polypeptide binding]; other site 370438000934 core dimer interface [polypeptide binding]; other site 370438000935 L10 interface [polypeptide binding]; other site 370438000936 L11 interface [polypeptide binding]; other site 370438000937 putative EF-Tu interaction site [polypeptide binding]; other site 370438000938 putative EF-G interaction site [polypeptide binding]; other site 370438000939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438000940 metal binding site [ion binding]; metal-binding site 370438000941 active site 370438000942 I-site; other site 370438000943 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438000944 Zn2+ binding site [ion binding]; other site 370438000945 Mg2+ binding site [ion binding]; other site 370438000946 Uncharacterized conserved protein [Function unknown]; Region: COG3287 370438000947 FIST N domain; Region: FIST; cl10701 370438000948 FIST C domain; Region: FIST_C; pfam10442 370438000949 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 370438000950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 370438000951 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 370438000952 RPB10 interaction site [polypeptide binding]; other site 370438000953 RPB11 interaction site [polypeptide binding]; other site 370438000954 RPB3 interaction site [polypeptide binding]; other site 370438000955 RPB12 interaction site [polypeptide binding]; other site 370438000956 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 370438000957 RPB1 interaction site [polypeptide binding]; other site 370438000958 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 370438000959 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 370438000960 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 370438000961 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 370438000962 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 370438000963 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 370438000964 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 370438000965 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 370438000966 G-loop; other site 370438000967 DNA binding site [nucleotide binding] 370438000968 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 370438000969 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 370438000970 S17 interaction site [polypeptide binding]; other site 370438000971 S8 interaction site; other site 370438000972 16S rRNA interaction site [nucleotide binding]; other site 370438000973 streptomycin interaction site [chemical binding]; other site 370438000974 23S rRNA interaction site [nucleotide binding]; other site 370438000975 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 370438000976 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 370438000977 elongation factor G; Reviewed; Region: PRK00007 370438000978 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 370438000979 G1 box; other site 370438000980 putative GEF interaction site [polypeptide binding]; other site 370438000981 GTP/Mg2+ binding site [chemical binding]; other site 370438000982 Switch I region; other site 370438000983 G2 box; other site 370438000984 G3 box; other site 370438000985 Switch II region; other site 370438000986 G4 box; other site 370438000987 G5 box; other site 370438000988 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 370438000989 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 370438000990 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 370438000991 elongation factor Tu; Reviewed; Region: PRK00049 370438000992 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 370438000993 G1 box; other site 370438000994 GEF interaction site [polypeptide binding]; other site 370438000995 GTP/Mg2+ binding site [chemical binding]; other site 370438000996 Switch I region; other site 370438000997 G2 box; other site 370438000998 G3 box; other site 370438000999 Switch II region; other site 370438001000 G4 box; other site 370438001001 G5 box; other site 370438001002 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 370438001003 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 370438001004 Antibiotic Binding Site [chemical binding]; other site 370438001005 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 370438001006 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 370438001007 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 370438001008 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 370438001009 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 370438001010 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 370438001011 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 370438001012 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 370438001013 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 370438001014 putative translocon binding site; other site 370438001015 protein-rRNA interface [nucleotide binding]; other site 370438001016 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 370438001017 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 370438001018 G-X-X-G motif; other site 370438001019 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 370438001020 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 370438001021 23S rRNA interface [nucleotide binding]; other site 370438001022 5S rRNA interface [nucleotide binding]; other site 370438001023 putative antibiotic binding site [chemical binding]; other site 370438001024 L25 interface [polypeptide binding]; other site 370438001025 L27 interface [polypeptide binding]; other site 370438001026 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 370438001027 23S rRNA interface [nucleotide binding]; other site 370438001028 putative translocon interaction site; other site 370438001029 signal recognition particle (SRP54) interaction site; other site 370438001030 L23 interface [polypeptide binding]; other site 370438001031 trigger factor interaction site; other site 370438001032 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 370438001033 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 370438001034 KOW motif; Region: KOW; cl00354 370438001035 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 370438001036 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 370438001037 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 370438001038 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 370438001039 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 370438001040 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 370438001041 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 370438001042 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 370438001043 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 370438001044 5S rRNA interface [nucleotide binding]; other site 370438001045 L5 interface [polypeptide binding]; other site 370438001046 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 370438001047 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 370438001048 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 370438001049 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 370438001050 23S rRNA binding site [nucleotide binding]; other site 370438001051 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 370438001052 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 370438001053 SecY translocase; Region: SecY; pfam00344 370438001054 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 370438001055 active site 370438001056 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 370438001057 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 370438001058 rRNA binding site [nucleotide binding]; other site 370438001059 predicted 30S ribosome binding site; other site 370438001060 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 370438001061 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 370438001062 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 370438001063 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 370438001064 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 370438001065 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 370438001066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370438001067 RNA binding surface [nucleotide binding]; other site 370438001068 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 370438001069 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 370438001070 alphaNTD - beta interaction site [polypeptide binding]; other site 370438001071 alphaNTD homodimer interface [polypeptide binding]; other site 370438001072 alphaNTD - beta' interaction site [polypeptide binding]; other site 370438001073 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 370438001074 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 370438001075 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 370438001076 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438001077 Walker A/P-loop; other site 370438001078 ATP binding site [chemical binding]; other site 370438001079 Q-loop/lid; other site 370438001080 ABC transporter signature motif; other site 370438001081 Walker B; other site 370438001082 D-loop; other site 370438001083 H-loop/switch region; other site 370438001084 Protein of unknown function (DUF1602); Region: DUF1602; pfam07673 370438001085 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 370438001086 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438001087 Walker A/P-loop; other site 370438001088 ATP binding site [chemical binding]; other site 370438001089 Q-loop/lid; other site 370438001090 ABC transporter signature motif; other site 370438001091 Walker B; other site 370438001092 D-loop; other site 370438001093 H-loop/switch region; other site 370438001094 Cobalt transport protein; Region: CbiQ; cl00463 370438001095 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 370438001096 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 370438001097 dimerization interface 3.5A [polypeptide binding]; other site 370438001098 active site 370438001099 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 370438001100 23S rRNA interface [nucleotide binding]; other site 370438001101 L3 interface [polypeptide binding]; other site 370438001102 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 370438001103 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 370438001104 active site 370438001105 NTP binding site [chemical binding]; other site 370438001106 metal binding triad [ion binding]; metal-binding site 370438001107 antibiotic binding site [chemical binding]; other site 370438001108 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 370438001109 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 370438001110 active site 370438001111 metal binding site [ion binding]; metal-binding site 370438001112 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438001113 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 370438001114 putative active site [active] 370438001115 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 370438001116 HTH-like domain; Region: HTH_21; pfam13276 370438001117 Integrase core domain; Region: rve; cl01316 370438001118 Integrase core domain; Region: rve_3; cl15866 370438001119 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 370438001120 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 370438001121 Cupin domain; Region: Cupin_2; cl09118 370438001122 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438001123 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 370438001124 putative active site [active] 370438001125 Protein of unknown function (DUF1616); Region: DUF1616; cl01959 370438001126 CAAX protease self-immunity; Region: Abi; cl00558 370438001127 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 370438001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 370438001131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001132 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 370438001133 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 370438001134 putative trimer interface [polypeptide binding]; other site 370438001135 putative active site [active] 370438001136 putative substrate binding site [chemical binding]; other site 370438001137 putative CoA binding site [chemical binding]; other site 370438001138 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 370438001139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001140 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 370438001141 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 370438001142 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 370438001143 Ligand binding site; other site 370438001144 Putative Catalytic site; other site 370438001145 DXD motif; other site 370438001146 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 370438001147 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 370438001148 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 370438001149 active site 370438001150 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 370438001151 homodimer interface [polypeptide binding]; other site 370438001152 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 370438001153 AMP-binding enzyme; Region: AMP-binding; cl15778 370438001154 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 370438001155 Transposase domain (DUF772); Region: DUF772; cl15789 370438001156 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438001157 Transposase domain (DUF772); Region: DUF772; cl15789 370438001158 DDE superfamily endonuclease; Region: DDE_5; cl02413 370438001159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438001160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438001161 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370438001162 Transposase domain (DUF772); Region: DUF772; cl15789 370438001163 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438001164 Transposase domain (DUF772); Region: DUF772; cl15789 370438001165 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 370438001166 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 370438001167 inhibitor-cofactor binding pocket; inhibition site 370438001168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438001169 catalytic residue [active] 370438001170 MatE; Region: MatE; cl10513 370438001171 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438001172 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 370438001173 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 370438001174 active site 370438001175 substrate binding site [chemical binding]; other site 370438001176 metal binding site [ion binding]; metal-binding site 370438001177 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 370438001178 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438001179 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 370438001180 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 370438001181 putative active site [active] 370438001182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438001183 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 370438001184 ATP-binding site [chemical binding]; other site 370438001185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438001186 ATP-binding site [chemical binding]; other site 370438001187 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 370438001188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438001189 SWIM zinc finger; Region: SWIM; cl15408 370438001190 SNF2 Helicase protein; Region: DUF3670; pfam12419 370438001191 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 370438001192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438001193 ATP binding site [chemical binding]; other site 370438001194 putative Mg++ binding site [ion binding]; other site 370438001195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438001196 nucleotide binding region [chemical binding]; other site 370438001197 ATP-binding site [chemical binding]; other site 370438001198 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 370438001199 oligomeric interface; other site 370438001200 putative active site [active] 370438001201 homodimer interface [polypeptide binding]; other site 370438001202 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 370438001203 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438001204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370438001205 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370438001206 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370438001207 Walker A/P-loop; other site 370438001208 ATP binding site [chemical binding]; other site 370438001209 Q-loop/lid; other site 370438001210 ABC transporter signature motif; other site 370438001211 Walker B; other site 370438001212 D-loop; other site 370438001213 H-loop/switch region; other site 370438001214 S-layer homology domain; Region: SLH; pfam00395 370438001215 S-layer homology domain; Region: SLH; pfam00395 370438001216 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370438001217 S-layer homology domain; Region: SLH; pfam00395 370438001218 S-layer homology domain; Region: SLH; pfam00395 370438001219 S-layer homology domain; Region: SLH; pfam00395 370438001220 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 370438001221 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 370438001222 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 370438001223 YokU-like protein; Region: YokU; cl15819 370438001224 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 370438001225 Gas vesicle protein; Region: Gas_vesicle; cl02954 370438001226 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 370438001227 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 370438001228 Gas vesicle protein K; Region: GvpK; pfam05121 370438001229 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 370438001230 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 370438001231 Gas vesicle protein G; Region: GvpG; pfam05120 370438001232 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 370438001233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001234 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 370438001235 Walker A motif; other site 370438001236 ATP binding site [chemical binding]; other site 370438001237 Walker B motif; other site 370438001238 arginine finger; other site 370438001239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001240 Walker A motif; other site 370438001241 ATP binding site [chemical binding]; other site 370438001242 Walker B motif; other site 370438001243 arginine finger; other site 370438001244 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 370438001245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001246 Walker A motif; other site 370438001247 ATP binding site [chemical binding]; other site 370438001248 Walker B motif; other site 370438001249 arginine finger; other site 370438001250 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 370438001251 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 370438001252 Gas vesicle protein; Region: Gas_vesicle; cl02954 370438001253 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 370438001254 active site 370438001255 NTP binding site [chemical binding]; other site 370438001256 metal binding triad [ion binding]; metal-binding site 370438001257 HEPN domain; Region: HEPN; cl00824 370438001258 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 370438001259 active site 370438001260 metal binding site [ion binding]; metal-binding site 370438001261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438001262 putative DNA binding site [nucleotide binding]; other site 370438001263 putative Zn2+ binding site [ion binding]; other site 370438001264 Methyltransferase domain; Region: Methyltransf_31; pfam13847 370438001265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438001266 S-adenosylmethionine binding site [chemical binding]; other site 370438001267 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 370438001268 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 370438001269 NAD binding site [chemical binding]; other site 370438001270 homodimer interface [polypeptide binding]; other site 370438001271 active site 370438001272 substrate binding site [chemical binding]; other site 370438001273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 370438001274 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 370438001275 Domain of unknown function DUF20; Region: UPF0118; pfam01594 370438001276 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 370438001277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001278 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 370438001279 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 370438001280 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 370438001281 Helix-turn-helix domains; Region: HTH; cl00088 370438001282 dimerization interface [polypeptide binding]; other site 370438001283 putative Zn2+ binding site [ion binding]; other site 370438001284 putative DNA binding site [nucleotide binding]; other site 370438001285 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 370438001286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 370438001287 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 370438001288 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 370438001289 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 370438001290 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 370438001291 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 370438001292 protein binding site [polypeptide binding]; other site 370438001293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438001294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438001295 active site 370438001296 phosphorylation site [posttranslational modification] 370438001297 intermolecular recognition site; other site 370438001298 dimerization interface [polypeptide binding]; other site 370438001299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438001300 DNA binding site [nucleotide binding] 370438001301 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 370438001302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438001303 dimerization interface [polypeptide binding]; other site 370438001304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438001305 dimer interface [polypeptide binding]; other site 370438001306 phosphorylation site [posttranslational modification] 370438001307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438001308 ATP binding site [chemical binding]; other site 370438001309 Mg2+ binding site [ion binding]; other site 370438001310 G-X-G motif; other site 370438001311 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 370438001312 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 370438001313 transmembrane helices; other site 370438001314 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 370438001315 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 370438001316 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 370438001317 transmembrane helices; other site 370438001318 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 370438001319 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 370438001320 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 370438001321 Cation transport protein; Region: TrkH; cl10514 370438001322 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 370438001323 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 370438001324 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 370438001325 TM-ABC transporter signature motif; other site 370438001326 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 370438001327 TM-ABC transporter signature motif; other site 370438001328 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 370438001329 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 370438001330 Walker A/P-loop; other site 370438001331 ATP binding site [chemical binding]; other site 370438001332 Q-loop/lid; other site 370438001333 ABC transporter signature motif; other site 370438001334 Walker B; other site 370438001335 D-loop; other site 370438001336 H-loop/switch region; other site 370438001337 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 370438001338 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 370438001339 Walker A/P-loop; other site 370438001340 ATP binding site [chemical binding]; other site 370438001341 Q-loop/lid; other site 370438001342 ABC transporter signature motif; other site 370438001343 Walker B; other site 370438001344 D-loop; other site 370438001345 H-loop/switch region; other site 370438001346 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 370438001347 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 370438001348 LysE type translocator; Region: LysE; cl00565 370438001349 hypothetical protein; Provisional; Region: PRK03881 370438001350 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 370438001351 AMMECR1; Region: AMMECR1; cl00911 370438001352 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 370438001353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438001354 FeS/SAM binding site; other site 370438001355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438001356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438001357 G1 box; other site 370438001358 G1 box; other site 370438001359 GTP/Mg2+ binding site [chemical binding]; other site 370438001360 GTP/Mg2+ binding site [chemical binding]; other site 370438001361 G2 box; other site 370438001362 G2 box; other site 370438001363 Switch I region; other site 370438001364 G3 box; other site 370438001365 Switch II region; other site 370438001366 G4 box; other site 370438001367 G5 box; other site 370438001368 TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666 370438001369 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 370438001370 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 370438001371 DXD motif; other site 370438001372 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 370438001373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438001374 Walker A/P-loop; other site 370438001375 ATP binding site [chemical binding]; other site 370438001376 Q-loop/lid; other site 370438001377 ABC transporter signature motif; other site 370438001378 Walker B; other site 370438001379 D-loop; other site 370438001380 H-loop/switch region; other site 370438001381 AMP-binding enzyme; Region: AMP-binding; cl15778 370438001382 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 370438001383 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 370438001384 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 370438001385 NodB motif; other site 370438001386 active site 370438001387 catalytic site [active] 370438001388 Cd binding site [ion binding]; other site 370438001389 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 370438001390 putative FMN binding site [chemical binding]; other site 370438001391 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438001392 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438001393 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 370438001394 Transcriptional regulator [Transcription]; Region: IclR; COG1414 370438001395 Helix-turn-helix domains; Region: HTH; cl00088 370438001396 Bacterial transcriptional regulator; Region: IclR; pfam01614 370438001397 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 370438001398 4Fe-4S binding domain; Region: Fer4; cl02805 370438001399 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370438001400 active site 370438001401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 370438001402 acetaldehyde dehydrogenase; Validated; Region: PRK08300 370438001403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001404 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 370438001405 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 370438001406 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 370438001407 active site 370438001408 catalytic residues [active] 370438001409 metal binding site [ion binding]; metal-binding site 370438001410 DmpG-like communication domain; Region: DmpG_comm; pfam07836 370438001411 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438001412 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 370438001413 active site 370438001414 NAD binding site [chemical binding]; other site 370438001415 metal binding site [ion binding]; metal-binding site 370438001416 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 370438001417 MPT binding site; other site 370438001418 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 370438001419 4Fe-4S binding domain; Region: Fer4; cl02805 370438001420 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438001421 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438001422 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438001423 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438001424 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 370438001425 putative active site [active] 370438001426 metal binding site [ion binding]; metal-binding site 370438001427 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 370438001428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001429 CoA-ligase; Region: Ligase_CoA; cl02894 370438001430 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438001431 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 370438001432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438001433 DRTGG domain; Region: DRTGG; cl12147 370438001434 Sodium:solute symporter family; Region: SSF; cl00456 370438001435 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438001436 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438001437 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438001438 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 370438001439 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438001440 active site 370438001441 NAD binding site [chemical binding]; other site 370438001442 metal binding site [ion binding]; metal-binding site 370438001443 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 370438001444 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 370438001445 MoaE interaction surface [polypeptide binding]; other site 370438001446 MoeB interaction surface [polypeptide binding]; other site 370438001447 thiocarboxylated glycine; other site 370438001448 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 370438001449 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 370438001450 ATP binding site [chemical binding]; other site 370438001451 substrate interface [chemical binding]; other site 370438001452 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 370438001453 putative active site [active] 370438001454 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438001455 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 370438001456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001457 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 370438001458 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 370438001459 heterotetramer interface [polypeptide binding]; other site 370438001460 active site pocket [active] 370438001461 cleavage site 370438001462 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 370438001463 feedback inhibition sensing region; other site 370438001464 homohexameric interface [polypeptide binding]; other site 370438001465 nucleotide binding site [chemical binding]; other site 370438001466 N-acetyl-L-glutamate binding site [chemical binding]; other site 370438001467 acetylornithine aminotransferase; Provisional; Region: PRK02627 370438001468 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 370438001469 inhibitor-cofactor binding pocket; inhibition site 370438001470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438001471 catalytic residue [active] 370438001472 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 370438001473 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370438001474 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438001475 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 370438001476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370438001477 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438001478 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 370438001479 IMP binding site; other site 370438001480 dimer interface [polypeptide binding]; other site 370438001481 interdomain contacts; other site 370438001482 partial ornithine binding site; other site 370438001483 ornithine carbamoyltransferase; Provisional; Region: PRK00779 370438001484 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 370438001485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001486 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 370438001487 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 370438001488 ANP binding site [chemical binding]; other site 370438001489 Substrate Binding Site II [chemical binding]; other site 370438001490 Substrate Binding Site I [chemical binding]; other site 370438001491 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 370438001492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001493 Walker A motif; other site 370438001494 ATP binding site [chemical binding]; other site 370438001495 Walker B motif; other site 370438001496 arginine finger; other site 370438001497 Helix-turn-helix domains; Region: HTH; cl00088 370438001498 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438001499 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438001500 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438001501 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 370438001502 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438001503 dimer interface [polypeptide binding]; other site 370438001504 active site 370438001505 metal binding site [ion binding]; metal-binding site 370438001506 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 370438001507 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438001508 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438001509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438001510 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 370438001511 FAD binding site [chemical binding]; other site 370438001512 homotetramer interface [polypeptide binding]; other site 370438001513 substrate binding pocket [chemical binding]; other site 370438001514 catalytic base [active] 370438001515 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 370438001516 Ligand binding site [chemical binding]; other site 370438001517 Electron transfer flavoprotein domain; Region: ETF; pfam01012 370438001518 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 370438001519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 370438001520 substrate binding site [chemical binding]; other site 370438001521 oxyanion hole (OAH) forming residues; other site 370438001522 trimer interface [polypeptide binding]; other site 370438001523 argininosuccinate lyase; Provisional; Region: PRK00855 370438001524 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 370438001525 active sites [active] 370438001526 tetramer interface [polypeptide binding]; other site 370438001527 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 370438001528 Prephenate dehydratase; Region: PDT; pfam00800 370438001529 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 370438001530 putative L-Phe binding site [chemical binding]; other site 370438001531 Chorismate mutase type II; Region: CM_2; cl00693 370438001532 NeuB family; Region: NeuB; cl00496 370438001533 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 370438001534 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370438001535 biotin synthase; Region: bioB; TIGR00433 370438001536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438001537 FeS/SAM binding site; other site 370438001538 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 370438001539 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 370438001540 dinuclear metal binding motif [ion binding]; other site 370438001541 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 370438001542 homodimer interface [polypeptide binding]; other site 370438001543 substrate-cofactor binding pocket; other site 370438001544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438001545 catalytic residue [active] 370438001546 Dehydratase family; Region: ILVD_EDD; cl00340 370438001547 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 370438001548 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 370438001549 PYR/PP interface [polypeptide binding]; other site 370438001550 dimer interface [polypeptide binding]; other site 370438001551 TPP binding site [chemical binding]; other site 370438001552 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 370438001553 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 370438001554 TPP-binding site [chemical binding]; other site 370438001555 dimer interface [polypeptide binding]; other site 370438001556 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 370438001557 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 370438001558 putative valine binding site [chemical binding]; other site 370438001559 dimer interface [polypeptide binding]; other site 370438001560 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 370438001561 ketol-acid reductoisomerase; Provisional; Region: PRK05479 370438001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001563 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 370438001564 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 370438001565 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 370438001566 PYR/PP interface [polypeptide binding]; other site 370438001567 dimer interface [polypeptide binding]; other site 370438001568 TPP binding site [chemical binding]; other site 370438001569 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 370438001570 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 370438001571 TPP-binding site [chemical binding]; other site 370438001572 dimer interface [polypeptide binding]; other site 370438001573 2-isopropylmalate synthase; Validated; Region: PRK00915 370438001574 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 370438001575 active site 370438001576 catalytic residues [active] 370438001577 metal binding site [ion binding]; metal-binding site 370438001578 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 370438001579 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 370438001580 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 370438001581 substrate binding site [chemical binding]; other site 370438001582 ligand binding site [chemical binding]; other site 370438001583 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 370438001584 substrate binding site [chemical binding]; other site 370438001585 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 370438001586 tartrate dehydrogenase; Provisional; Region: PRK08194 370438001587 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 370438001588 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 370438001589 active site 370438001590 catalytic residues [active] 370438001591 metal binding site [ion binding]; metal-binding site 370438001592 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 370438001593 Uncharacterized conserved protein [Function unknown]; Region: COG1624 370438001594 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 370438001595 YbbR-like protein; Region: YbbR; pfam07949 370438001596 YbbR-like protein; Region: YbbR; pfam07949 370438001597 YbbR-like protein; Region: YbbR; pfam07949 370438001598 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 370438001599 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 370438001600 active site 370438001601 substrate binding site [chemical binding]; other site 370438001602 metal binding site [ion binding]; metal-binding site 370438001603 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 370438001604 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 370438001605 glutaminase active site [active] 370438001606 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 370438001607 dimer interface [polypeptide binding]; other site 370438001608 active site 370438001609 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 370438001610 dimer interface [polypeptide binding]; other site 370438001611 active site 370438001612 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438001613 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 370438001614 AzlC protein; Region: AzlC; cl00570 370438001615 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 370438001616 Predicted permease; Region: DUF318; pfam03773 370438001617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438001618 dimerization interface [polypeptide binding]; other site 370438001619 putative DNA binding site [nucleotide binding]; other site 370438001620 putative Zn2+ binding site [ion binding]; other site 370438001621 PAS domain; Region: PAS_9; pfam13426 370438001622 GAF domain; Region: GAF; cl15785 370438001623 GAF domain; Region: GAF_2; pfam13185 370438001624 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438001625 metal binding site [ion binding]; metal-binding site 370438001626 active site 370438001627 I-site; other site 370438001628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438001629 Zn2+ binding site [ion binding]; other site 370438001630 Mg2+ binding site [ion binding]; other site 370438001631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001632 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370438001633 Walker A motif; other site 370438001634 ATP binding site [chemical binding]; other site 370438001635 Walker B motif; other site 370438001636 arginine finger; other site 370438001637 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 370438001638 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 370438001639 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 370438001640 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 370438001641 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 370438001642 CPxP motif; other site 370438001643 Sulphur transport; Region: Sulf_transp; cl01018 370438001644 TOBE domain; Region: TOBE_2; cl01440 370438001645 Flagellin N-methylase; Region: FliB; cl00497 370438001646 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 370438001647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438001648 Walker A/P-loop; other site 370438001649 ATP binding site [chemical binding]; other site 370438001650 Q-loop/lid; other site 370438001651 ABC transporter signature motif; other site 370438001652 Walker B; other site 370438001653 D-loop; other site 370438001654 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 370438001655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438001657 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370438001658 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 370438001659 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 370438001660 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 370438001661 active site 370438001662 homotetramer interface [polypeptide binding]; other site 370438001663 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 370438001664 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438001665 NlpC/P60 family; Region: NLPC_P60; cl11438 370438001666 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 370438001667 active site 370438001668 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 370438001669 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 370438001670 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 370438001671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438001672 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370438001673 Predicted permeases [General function prediction only]; Region: COG0701 370438001674 Predicted permease; Region: DUF318; pfam03773 370438001675 NMT1-like family; Region: NMT1_2; cl15260 370438001676 NMT1/THI5 like; Region: NMT1; pfam09084 370438001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438001678 dimer interface [polypeptide binding]; other site 370438001679 conserved gate region; other site 370438001680 ABC-ATPase subunit interface; other site 370438001681 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 370438001682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 370438001683 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 370438001684 Walker A/P-loop; other site 370438001685 ATP binding site [chemical binding]; other site 370438001686 Q-loop/lid; other site 370438001687 ABC transporter signature motif; other site 370438001688 Walker B; other site 370438001689 D-loop; other site 370438001690 H-loop/switch region; other site 370438001691 DsrE/DsrF-like family; Region: DrsE; cl00672 370438001692 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 370438001693 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 370438001694 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 370438001695 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 370438001696 putative [Fe4-S4] binding site [ion binding]; other site 370438001697 putative molybdopterin cofactor binding site [chemical binding]; other site 370438001698 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 370438001699 molybdopterin cofactor binding site; other site 370438001700 MOSC domain; Region: MOSC; pfam03473 370438001701 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 370438001702 trimerization site [polypeptide binding]; other site 370438001703 active site 370438001704 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 370438001705 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 370438001706 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 370438001707 switch II; other site 370438001708 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 370438001709 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 370438001710 P loop nucleotide binding; other site 370438001711 switch II; other site 370438001712 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 370438001713 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 370438001714 Walker A motif; other site 370438001715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438001716 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 370438001717 classical (c) SDRs; Region: SDR_c; cd05233 370438001718 NAD(P) binding site [chemical binding]; other site 370438001719 active site 370438001720 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 370438001721 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 370438001722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438001723 FeS/SAM binding site; other site 370438001724 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438001725 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 370438001726 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 370438001727 putative active site [active] 370438001728 putative FMN binding site [chemical binding]; other site 370438001729 putative substrate binding site [chemical binding]; other site 370438001730 putative catalytic residue [active] 370438001731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001732 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 370438001733 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 370438001734 putative active site [active] 370438001735 putative FMN binding site [chemical binding]; other site 370438001736 putative substrate binding site [chemical binding]; other site 370438001737 putative catalytic residue [active] 370438001738 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 370438001739 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 370438001740 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 370438001741 oxidoreductase; Provisional; Region: PRK10015 370438001742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001743 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 370438001744 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 370438001745 Ligand Binding Site [chemical binding]; other site 370438001746 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 370438001747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438001748 active site 370438001749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438001750 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 370438001751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438001752 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 370438001753 Thiamine pyrophosphokinase; Region: TPK; cd07995 370438001754 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 370438001755 active site 370438001756 dimerization interface [polypeptide binding]; other site 370438001757 thiamine binding site [chemical binding]; other site 370438001758 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 370438001759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438001760 active site 370438001761 phosphorylation site [posttranslational modification] 370438001762 intermolecular recognition site; other site 370438001763 dimerization interface [polypeptide binding]; other site 370438001764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001765 Walker A motif; other site 370438001766 ATP binding site [chemical binding]; other site 370438001767 Walker B motif; other site 370438001768 Helix-turn-helix domains; Region: HTH; cl00088 370438001769 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 370438001770 putative alcohol dehydrogenase; Provisional; Region: PRK09860 370438001771 dimer interface [polypeptide binding]; other site 370438001772 active site 370438001773 metal binding site [ion binding]; metal-binding site 370438001774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438001775 Zn2+ binding site [ion binding]; other site 370438001776 Mg2+ binding site [ion binding]; other site 370438001777 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 370438001778 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 370438001779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438001780 catalytic residue [active] 370438001781 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 370438001782 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438001783 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438001784 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438001785 Ubiquitin-like proteins; Region: UBQ; cl00155 370438001786 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 370438001787 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 370438001788 ATP binding site [chemical binding]; other site 370438001789 substrate interface [chemical binding]; other site 370438001790 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438001791 Beta propeller domain; Region: Beta_propel; pfam09826 370438001792 S-layer homology domain; Region: SLH; pfam00395 370438001793 S-layer homology domain; Region: SLH; pfam00395 370438001794 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 370438001795 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 370438001796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438001797 FeS/SAM binding site; other site 370438001798 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 370438001799 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 370438001800 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 370438001801 putative ADP-binding pocket [chemical binding]; other site 370438001802 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 370438001803 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438001804 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 370438001805 Mechanosensitive ion channel; Region: MS_channel; pfam00924 370438001806 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 370438001807 Dynamin family; Region: Dynamin_N; pfam00350 370438001808 G1 box; other site 370438001809 GTP/Mg2+ binding site [chemical binding]; other site 370438001810 G2 box; other site 370438001811 Switch I region; other site 370438001812 G3 box; other site 370438001813 Switch II region; other site 370438001814 G4 box; other site 370438001815 G5 box; other site 370438001816 Flagellin N-methylase; Region: FliB; cl00497 370438001817 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 370438001818 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 370438001819 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 370438001820 active site 370438001821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 370438001822 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 370438001823 putative NAD(P) binding site [chemical binding]; other site 370438001824 catalytic Zn binding site [ion binding]; other site 370438001825 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 370438001826 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 370438001827 putative active site; other site 370438001828 catalytic residue [active] 370438001829 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 370438001830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438001831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 370438001832 putative substrate translocation pore; other site 370438001833 Ferritin-like domain; Region: Ferritin; pfam00210 370438001834 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 370438001835 dinuclear metal binding motif [ion binding]; other site 370438001836 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 370438001837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438001838 dimer interface [polypeptide binding]; other site 370438001839 putative CheW interface [polypeptide binding]; other site 370438001840 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 370438001841 stage V sporulation protein T; Region: spore_V_T; TIGR02851 370438001842 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438001843 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 370438001844 thiS-thiF/thiG interaction site; other site 370438001845 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 370438001846 ThiS interaction site; other site 370438001847 putative active site [active] 370438001848 tetramer interface [polypeptide binding]; other site 370438001849 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 370438001850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438001851 FeS/SAM binding site; other site 370438001852 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 370438001853 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 370438001854 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 370438001855 putative ATP binding site [chemical binding]; other site 370438001856 putative substrate interface [chemical binding]; other site 370438001857 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 370438001858 thiamine phosphate binding site [chemical binding]; other site 370438001859 active site 370438001860 pyrophosphate binding site [ion binding]; other site 370438001861 ThiC family; Region: ThiC; cl08031 370438001862 Flavin Reductases; Region: FlaRed; cl00801 370438001863 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 370438001864 putative ADP-ribose binding site [chemical binding]; other site 370438001865 putative active site [active] 370438001866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438001867 dimerization interface [polypeptide binding]; other site 370438001868 putative DNA binding site [nucleotide binding]; other site 370438001869 putative Zn2+ binding site [ion binding]; other site 370438001870 Predicted permease; Region: DUF318; pfam03773 370438001871 Predicted permeases [General function prediction only]; Region: COG0701 370438001872 DGC domain; Region: DGC; cl01742 370438001873 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 370438001874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438001875 dimerization interface [polypeptide binding]; other site 370438001876 putative DNA binding site [nucleotide binding]; other site 370438001877 putative Zn2+ binding site [ion binding]; other site 370438001878 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 370438001879 Membrane transport protein; Region: Mem_trans; cl09117 370438001880 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 370438001881 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438001882 GAF domain; Region: GAF; cl15785 370438001883 Histidine kinase; Region: His_kinase; pfam06580 370438001884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438001885 ATP binding site [chemical binding]; other site 370438001886 Mg2+ binding site [ion binding]; other site 370438001887 G-X-G motif; other site 370438001888 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 370438001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438001890 active site 370438001891 phosphorylation site [posttranslational modification] 370438001892 intermolecular recognition site; other site 370438001893 dimerization interface [polypeptide binding]; other site 370438001894 LytTr DNA-binding domain; Region: LytTR; cl04498 370438001895 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 370438001896 putative carbohydrate kinase; Provisional; Region: PRK10565 370438001897 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 370438001898 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 370438001899 putative substrate binding site [chemical binding]; other site 370438001900 putative ATP binding site [chemical binding]; other site 370438001901 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 370438001902 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 370438001903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438001904 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 370438001905 alanine racemase; Reviewed; Region: alr; PRK00053 370438001906 active site 370438001907 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 370438001908 dimer interface [polypeptide binding]; other site 370438001909 substrate binding site [chemical binding]; other site 370438001910 catalytic residues [active] 370438001911 Protein of unknown function DUF89; Region: DUF89; cl15397 370438001912 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 370438001913 FMN binding site [chemical binding]; other site 370438001914 dimer interface [polypeptide binding]; other site 370438001915 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 370438001916 Nitrogen regulatory protein P-II; Region: P-II; cl00412 370438001917 Nitrogen regulatory protein P-II; Region: P-II; smart00938 370438001918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 370438001919 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 370438001920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438001921 dimer interface [polypeptide binding]; other site 370438001922 putative CheW interface [polypeptide binding]; other site 370438001923 Cache domain; Region: Cache_1; pfam02743 370438001924 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 370438001925 4Fe-4S binding domain; Region: Fer4; cl02805 370438001926 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 370438001927 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 370438001928 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 370438001929 4Fe-4S binding domain; Region: Fer4; cl02805 370438001930 Polysulphide reductase, NrfD; Region: NrfD; cl01295 370438001931 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 370438001932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438001933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438001934 DNA binding residues [nucleotide binding] 370438001935 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 370438001936 Putative zinc-finger; Region: zf-HC2; cl15806 370438001937 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 370438001938 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 370438001939 active site 370438001940 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 370438001941 dimer interface [polypeptide binding]; other site 370438001942 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 370438001943 Ligand Binding Site [chemical binding]; other site 370438001944 Molecular Tunnel; other site 370438001945 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 370438001946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438001947 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 370438001948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438001949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438001950 dimer interface [polypeptide binding]; other site 370438001951 conserved gate region; other site 370438001952 putative PBP binding loops; other site 370438001953 ABC-ATPase subunit interface; other site 370438001954 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438001955 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370438001956 Walker A/P-loop; other site 370438001957 ATP binding site [chemical binding]; other site 370438001958 Q-loop/lid; other site 370438001959 ABC transporter signature motif; other site 370438001960 Walker B; other site 370438001961 D-loop; other site 370438001962 H-loop/switch region; other site 370438001963 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 370438001964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438001965 active site 370438001966 phosphorylation site [posttranslational modification] 370438001967 intermolecular recognition site; other site 370438001968 dimerization interface [polypeptide binding]; other site 370438001969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438001970 Walker A motif; other site 370438001971 ATP binding site [chemical binding]; other site 370438001972 Walker B motif; other site 370438001973 arginine finger; other site 370438001974 Helix-turn-helix domains; Region: HTH; cl00088 370438001975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 370438001976 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 370438001977 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 370438001978 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 370438001979 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 370438001980 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 370438001981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370438001982 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 370438001983 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438001984 Cysteine-rich domain; Region: CCG; pfam02754 370438001985 Cysteine-rich domain; Region: CCG; pfam02754 370438001986 Methyltransferase domain; Region: Methyltransf_31; pfam13847 370438001987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438001988 S-adenosylmethionine binding site [chemical binding]; other site 370438001989 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 370438001990 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 370438001991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438001992 FeS/SAM binding site; other site 370438001993 AMP-binding enzyme; Region: AMP-binding; cl15778 370438001994 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 370438001995 XdhC Rossmann domain; Region: XdhC_C; pfam13478 370438001996 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 370438001997 metal-binding site 370438001998 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 370438001999 putative MPT binding site; other site 370438002000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370438002001 catalytic core [active] 370438002002 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438002003 Cysteine-rich domain; Region: CCG; pfam02754 370438002004 hypothetical protein; Provisional; Region: PRK06851 370438002005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002006 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370438002007 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 370438002008 catalytic residues [active] 370438002009 catalytic nucleophile [active] 370438002010 Recombinase; Region: Recombinase; pfam07508 370438002011 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370438002012 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 370438002013 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 370438002014 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 370438002015 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 370438002016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438002017 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 370438002018 Helix-turn-helix domains; Region: HTH; cl00088 370438002019 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 370438002020 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438002021 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 370438002022 putative active site [active] 370438002023 Protein of unknown function (DUF433); Region: DUF433; cl01030 370438002024 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 370438002025 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 370438002026 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl15461 370438002027 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 370438002028 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370438002029 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 370438002030 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 370438002031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002033 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 370438002034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438002035 ATP binding site [chemical binding]; other site 370438002036 putative Mg++ binding site [ion binding]; other site 370438002037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438002038 nucleotide binding region [chemical binding]; other site 370438002039 ATP-dependent helicase HepA; Validated; Region: PRK04914 370438002040 ATP-binding site [chemical binding]; other site 370438002041 PglZ domain; Region: PglZ; pfam08665 370438002042 HTH-like domain; Region: HTH_21; pfam13276 370438002043 Integrase core domain; Region: rve; cl01316 370438002044 Integrase core domain; Region: rve_3; cl15866 370438002045 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438002046 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 370438002047 MULE transposase domain; Region: MULE; pfam10551 370438002048 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 370438002049 5' RNA guide strand anchoring site; other site 370438002050 active site 370438002051 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 370438002052 putative active site [active] 370438002053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438002054 sequence-specific DNA binding site [nucleotide binding]; other site 370438002055 salt bridge; other site 370438002056 Domain of unknown function (DUF955); Region: DUF955; cl01076 370438002057 hypothetical protein; Provisional; Region: PRK06851 370438002058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002059 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 370438002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438002061 active site 370438002062 phosphorylation site [posttranslational modification] 370438002063 intermolecular recognition site; other site 370438002064 dimerization interface [polypeptide binding]; other site 370438002065 ANTAR domain; Region: ANTAR; cl04297 370438002066 glutamine synthetase, type I; Region: GlnA; TIGR00653 370438002067 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 370438002068 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370438002069 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 370438002070 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 370438002071 active site 370438002072 FMN binding site [chemical binding]; other site 370438002073 substrate binding site [chemical binding]; other site 370438002074 3Fe-4S cluster binding site [ion binding]; other site 370438002075 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 370438002076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438002077 active site 370438002078 phosphorylation site [posttranslational modification] 370438002079 intermolecular recognition site; other site 370438002080 dimerization interface [polypeptide binding]; other site 370438002081 ANTAR domain; Region: ANTAR; cl04297 370438002082 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 370438002083 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370438002084 glutamine synthetase, type I; Region: GlnA; TIGR00653 370438002085 glutamine synthetase, type I; Region: GlnA; TIGR00653 370438002086 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 370438002087 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370438002088 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 370438002089 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 370438002090 active site 370438002091 dimer interface [polypeptide binding]; other site 370438002092 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 370438002093 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 370438002094 active site 370438002095 FMN binding site [chemical binding]; other site 370438002096 substrate binding site [chemical binding]; other site 370438002097 3Fe-4S cluster binding site [ion binding]; other site 370438002098 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 370438002099 domain interface; other site 370438002100 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 370438002101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370438002102 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 370438002103 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 370438002104 putative valine binding site [chemical binding]; other site 370438002105 dimer interface [polypeptide binding]; other site 370438002106 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 370438002107 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 370438002108 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 370438002109 PemK-like protein; Region: PemK; cl00995 370438002110 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 370438002111 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370438002112 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 370438002113 active site 370438002114 Response regulator receiver domain; Region: Response_reg; pfam00072 370438002115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438002116 active site 370438002117 phosphorylation site [posttranslational modification] 370438002118 intermolecular recognition site; other site 370438002119 dimerization interface [polypeptide binding]; other site 370438002120 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 370438002121 Glycoprotease family; Region: Peptidase_M22; pfam00814 370438002122 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 370438002123 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370438002124 Cell division protein FtsA; Region: FtsA; cl11496 370438002125 Cell division protein FtsA; Region: FtsA; cl11496 370438002126 Protein of unknown function DUF72; Region: DUF72; cl00777 370438002127 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 370438002128 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 370438002129 dimer interface [polypeptide binding]; other site 370438002130 NAD binding site [chemical binding]; other site 370438002131 substrate binding site [chemical binding]; other site 370438002132 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370438002133 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 370438002134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002135 Walker A motif; other site 370438002136 ATP binding site [chemical binding]; other site 370438002137 Walker B motif; other site 370438002138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002139 ATP binding site [chemical binding]; other site 370438002140 Walker B motif; other site 370438002141 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 370438002142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002143 Walker A motif; other site 370438002144 ATP binding site [chemical binding]; other site 370438002145 Walker B motif; other site 370438002146 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 370438002147 Heme NO binding; Region: HNOB; cl15268 370438002148 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 370438002149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438002150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438002151 dimer interface [polypeptide binding]; other site 370438002152 phosphorylation site [posttranslational modification] 370438002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438002154 ATP binding site [chemical binding]; other site 370438002155 Mg2+ binding site [ion binding]; other site 370438002156 G-X-G motif; other site 370438002157 PemK-like protein; Region: PemK; cl00995 370438002158 Transposase domain (DUF772); Region: DUF772; cl15789 370438002159 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 370438002160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002161 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 370438002162 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 370438002163 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370438002164 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 370438002165 VanW like protein; Region: VanW; pfam04294 370438002166 G5 domain; Region: G5; pfam07501 370438002167 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 370438002168 putative active site [active] 370438002169 NADH dehydrogenase subunit 5; Region: ndhF; CHL00025 370438002170 PrcB C-terminal; Region: PrcB_C; pfam14343 370438002171 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438002172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 370438002173 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 370438002174 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 370438002175 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 370438002176 structural tetrad; other site 370438002177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438002178 putative substrate translocation pore; other site 370438002179 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 370438002180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438002181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438002182 DNA binding residues [nucleotide binding] 370438002183 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 370438002184 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 370438002185 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 370438002186 Walker A/P-loop; other site 370438002187 ATP binding site [chemical binding]; other site 370438002188 Q-loop/lid; other site 370438002189 ABC transporter signature motif; other site 370438002190 Walker B; other site 370438002191 D-loop; other site 370438002192 H-loop/switch region; other site 370438002193 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438002194 translocation protein TolB; Provisional; Region: tolB; PRK00178 370438002195 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 370438002196 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438002197 DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the...; Region: ABC_DrrA; cd03265 370438002198 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 370438002199 Walker A/P-loop; other site 370438002200 ATP binding site [chemical binding]; other site 370438002201 Q-loop/lid; other site 370438002202 ABC transporter signature motif; other site 370438002203 Walker B; other site 370438002204 D-loop; other site 370438002205 H-loop/switch region; other site 370438002206 Transcriptional regulators [Transcription]; Region: MarR; COG1846 370438002207 Helix-turn-helix domains; Region: HTH; cl00088 370438002208 hybrid cluster protein; Provisional; Region: PRK05290 370438002209 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438002210 ACS interaction site; other site 370438002211 CODH interaction site; other site 370438002212 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438002213 ACS interaction site; other site 370438002214 CODH interaction site; other site 370438002215 metal cluster binding site [ion binding]; other site 370438002216 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 370438002217 4Fe-4S binding domain; Region: Fer4; cl02805 370438002218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 370438002219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 370438002220 ligand binding site [chemical binding]; other site 370438002221 Helix-turn-helix domains; Region: HTH; cl00088 370438002222 SCP-2 sterol transfer family; Region: SCP2; cl01225 370438002223 Amino acid permease; Region: AA_permease_2; pfam13520 370438002224 Bacterial SH3 domain; Region: SH3_3; cl02551 370438002225 Bacterial SH3 domain; Region: SH3_3; cl02551 370438002226 Bacterial SH3 domain; Region: SH3_3; cl02551 370438002227 AMIN domain; Region: AMIN; pfam11741 370438002228 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 370438002229 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 370438002230 active site 370438002231 metal binding site [ion binding]; metal-binding site 370438002232 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 370438002233 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 370438002234 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370438002235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438002236 ribonuclease PH; Reviewed; Region: rph; PRK00173 370438002237 Ribonuclease PH; Region: RNase_PH_bact; cd11362 370438002238 hexamer interface [polypeptide binding]; other site 370438002239 active site 370438002240 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 370438002241 active site 370438002242 dimerization interface [polypeptide binding]; other site 370438002243 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 370438002244 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 370438002245 active site 370438002246 metal binding site [ion binding]; metal-binding site 370438002247 homotetramer interface [polypeptide binding]; other site 370438002248 enoyl-CoA hydratase; Provisional; Region: PRK06688 370438002249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 370438002250 substrate binding site [chemical binding]; other site 370438002251 oxyanion hole (OAH) forming residues; other site 370438002252 trimer interface [polypeptide binding]; other site 370438002253 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 370438002254 nucleotide binding site/active site [active] 370438002255 HIT family signature motif; other site 370438002256 catalytic residue [active] 370438002257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438002258 dimerization interface [polypeptide binding]; other site 370438002259 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 370438002260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438002261 dimer interface [polypeptide binding]; other site 370438002262 putative CheW interface [polypeptide binding]; other site 370438002263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438002264 non-specific DNA binding site [nucleotide binding]; other site 370438002265 salt bridge; other site 370438002266 sequence-specific DNA binding site [nucleotide binding]; other site 370438002267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438002268 Zn2+ binding site [ion binding]; other site 370438002269 Mg2+ binding site [ion binding]; other site 370438002270 FOG: CBS domain [General function prediction only]; Region: COG0517 370438002271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc2; cd04599 370438002272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438002273 metal binding site [ion binding]; metal-binding site 370438002274 active site 370438002275 I-site; other site 370438002276 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 370438002277 trigger factor; Provisional; Region: tig; PRK01490 370438002278 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 370438002279 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 370438002280 Clp protease; Region: CLP_protease; pfam00574 370438002281 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 370438002282 oligomer interface [polypeptide binding]; other site 370438002283 active site residues [active] 370438002284 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 370438002285 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 370438002286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002287 Walker A motif; other site 370438002288 ATP binding site [chemical binding]; other site 370438002289 Walker B motif; other site 370438002290 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370438002291 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 370438002292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002293 Walker A motif; other site 370438002294 ATP binding site [chemical binding]; other site 370438002295 Walker B motif; other site 370438002296 arginine finger; other site 370438002297 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370438002298 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 370438002299 Found in ATP-dependent protease La (LON); Region: LON; smart00464 370438002300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002301 Walker A motif; other site 370438002302 ATP binding site [chemical binding]; other site 370438002303 Walker B motif; other site 370438002304 arginine finger; other site 370438002305 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370438002306 Predicted GTPase [General function prediction only]; Region: COG0218 370438002307 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 370438002308 G1 box; other site 370438002309 GTP/Mg2+ binding site [chemical binding]; other site 370438002310 Switch I region; other site 370438002311 G2 box; other site 370438002312 G3 box; other site 370438002313 Switch II region; other site 370438002314 G4 box; other site 370438002315 G5 box; other site 370438002316 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 370438002317 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 370438002318 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 370438002319 HIGH motif; other site 370438002320 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 370438002321 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 370438002322 active site 370438002323 KMSKS motif; other site 370438002324 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 370438002325 tRNA binding surface [nucleotide binding]; other site 370438002326 anticodon binding site; other site 370438002327 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 370438002328 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 370438002329 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370438002330 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370438002331 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 370438002332 Maf-like protein; Region: Maf; pfam02545 370438002333 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 370438002334 active site 370438002335 dimer interface [polypeptide binding]; other site 370438002336 hypothetical protein; Reviewed; Region: PRK00024 370438002337 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 370438002338 MPN+ (JAMM) motif; other site 370438002339 Zinc-binding site [ion binding]; other site 370438002340 rod shape-determining protein MreB; Provisional; Region: PRK13927 370438002341 Cell division protein FtsA; Region: FtsA; cl11496 370438002342 rod shape-determining protein MreC; Region: MreC; pfam04085 370438002343 rod shape-determining protein MreD; Region: MreD; cl01087 370438002344 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 370438002345 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 370438002346 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438002347 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 370438002348 septum site-determining protein MinD; Region: minD_bact; TIGR01968 370438002349 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 370438002350 Switch I; other site 370438002351 Switch II; other site 370438002352 Septum formation topological specificity factor MinE; Region: MinE; cl00538 370438002353 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 370438002354 Peptidase family M23; Region: Peptidase_M23; pfam01551 370438002355 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 370438002356 putative substrate binding region [chemical binding]; other site 370438002357 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 370438002358 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 370438002359 B12 binding site [chemical binding]; other site 370438002360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002361 FeS/SAM binding site; other site 370438002362 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 370438002363 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 370438002364 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 370438002365 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 370438002366 homodimer interface [polypeptide binding]; other site 370438002367 oligonucleotide binding site [chemical binding]; other site 370438002368 TRAM domain; Region: TRAM; cl01282 370438002369 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 370438002370 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 370438002371 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 370438002372 GTPase CgtA; Reviewed; Region: obgE; PRK12297 370438002373 GTP1/OBG; Region: GTP1_OBG; pfam01018 370438002374 Obg GTPase; Region: Obg; cd01898 370438002375 G1 box; other site 370438002376 GTP/Mg2+ binding site [chemical binding]; other site 370438002377 Switch I region; other site 370438002378 G2 box; other site 370438002379 G3 box; other site 370438002380 Switch II region; other site 370438002381 G4 box; other site 370438002382 G5 box; other site 370438002383 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 370438002384 gamma-glutamyl kinase; Provisional; Region: PRK05429 370438002385 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 370438002386 nucleotide binding site [chemical binding]; other site 370438002387 homotetrameric interface [polypeptide binding]; other site 370438002388 putative phosphate binding site [ion binding]; other site 370438002389 putative allosteric binding site; other site 370438002390 PUA domain; Region: PUA; cl00607 370438002391 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 370438002392 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 370438002393 active site 370438002394 (T/H)XGH motif; other site 370438002395 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 370438002396 RNA/DNA binding site [nucleotide binding]; other site 370438002397 RRM dimerization site [polypeptide binding]; other site 370438002398 Oligomerisation domain; Region: Oligomerisation; cl00519 370438002399 AMP-binding domain protein; Validated; Region: PRK08315 370438002400 AMP-binding enzyme; Region: AMP-binding; cl15778 370438002401 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 370438002402 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 370438002403 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 370438002404 HIGH motif; other site 370438002405 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 370438002406 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 370438002407 active site 370438002408 KMSKS motif; other site 370438002409 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 370438002410 tRNA binding surface [nucleotide binding]; other site 370438002411 Helix-turn-helix domains; Region: HTH; cl00088 370438002412 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 370438002413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438002414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438002415 dimer interface [polypeptide binding]; other site 370438002416 conserved gate region; other site 370438002417 putative PBP binding loops; other site 370438002418 ABC-ATPase subunit interface; other site 370438002419 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 370438002420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002421 Walker A/P-loop; other site 370438002422 ATP binding site [chemical binding]; other site 370438002423 Q-loop/lid; other site 370438002424 ABC transporter signature motif; other site 370438002425 Walker B; other site 370438002426 D-loop; other site 370438002427 H-loop/switch region; other site 370438002428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438002429 PAS domain; Region: PAS_9; pfam13426 370438002430 putative active site [active] 370438002431 heme pocket [chemical binding]; other site 370438002432 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370438002433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002434 Walker A motif; other site 370438002435 ATP binding site [chemical binding]; other site 370438002436 Walker B motif; other site 370438002437 Helix-turn-helix domains; Region: HTH; cl00088 370438002438 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 370438002439 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 370438002440 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 370438002441 TPP-binding site [chemical binding]; other site 370438002442 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 370438002443 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 370438002444 PYR/PP interface [polypeptide binding]; other site 370438002445 TPP binding site [chemical binding]; other site 370438002446 dimer interface [polypeptide binding]; other site 370438002447 substrate binding site [chemical binding]; other site 370438002448 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438002449 Ferredoxin [Energy production and conversion]; Region: COG1146 370438002450 Protein of unknown function (DUF421); Region: DUF421; cl00990 370438002451 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 370438002452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002453 Walker A motif; other site 370438002454 ATP binding site [chemical binding]; other site 370438002455 Walker B motif; other site 370438002456 arginine finger; other site 370438002457 Helix-turn-helix domains; Region: HTH; cl00088 370438002458 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438002459 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 370438002460 putative active site [active] 370438002461 metal binding site [ion binding]; metal-binding site 370438002462 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438002463 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438002464 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438002465 Permease family; Region: Xan_ur_permease; pfam00860 370438002466 SLBB domain; Region: SLBB; pfam10531 370438002467 comEA protein; Region: comE; TIGR01259 370438002468 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 370438002469 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 370438002470 N-acetyl-D-glucosamine binding site [chemical binding]; other site 370438002471 catalytic residue [active] 370438002472 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 370438002473 Competence protein; Region: Competence; cl00471 370438002474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438002475 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 370438002476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438002477 ATP binding site [chemical binding]; other site 370438002478 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 370438002479 putative Mg++ binding site [ion binding]; other site 370438002480 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 370438002481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438002482 nucleotide binding region [chemical binding]; other site 370438002483 ATP-binding site [chemical binding]; other site 370438002484 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 370438002485 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 370438002486 Mrr N-terminal domain; Region: Mrr_N; pfam14338 370438002487 Protein of unknown function (DUF499); Region: DUF499; pfam04465 370438002488 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 370438002489 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438002490 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438002491 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438002492 Domain of unknown function DUF77; Region: DUF77; cl00307 370438002493 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 370438002494 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 370438002495 putative uracil/xanthine transporter; Provisional; Region: PRK11412 370438002496 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 370438002497 Membrane protein of unknown function; Region: DUF360; cl00850 370438002498 stage II sporulation protein P; Region: spore_II_P; TIGR02867 370438002499 GTP-binding protein LepA; Provisional; Region: PRK05433 370438002500 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 370438002501 G1 box; other site 370438002502 putative GEF interaction site [polypeptide binding]; other site 370438002503 GTP/Mg2+ binding site [chemical binding]; other site 370438002504 Switch I region; other site 370438002505 G2 box; other site 370438002506 G3 box; other site 370438002507 Switch II region; other site 370438002508 G4 box; other site 370438002509 G5 box; other site 370438002510 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 370438002511 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 370438002512 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 370438002513 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 370438002514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002515 FeS/SAM binding site; other site 370438002516 HemN C-terminal domain; Region: HemN_C; pfam06969 370438002517 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 370438002518 Helix-turn-helix domains; Region: HTH; cl00088 370438002519 HrcA protein C terminal domain; Region: HrcA; pfam01628 370438002520 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 370438002521 ring oligomerisation interface [polypeptide binding]; other site 370438002522 TCP-1/cpn60 chaperonin family; Region: Cpn60_TCP1; pfam00118 370438002523 ATP/Mg binding site [chemical binding]; other site 370438002524 hinge regions; other site 370438002525 stacking interactions; other site 370438002526 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 370438002527 dimer interface [polypeptide binding]; other site 370438002528 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 370438002529 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 370438002530 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 370438002531 chaperone protein DnaJ; Provisional; Region: PRK10767 370438002532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 370438002533 HSP70 interaction site [polypeptide binding]; other site 370438002534 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 370438002535 substrate binding site [polypeptide binding]; other site 370438002536 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 370438002537 Zn binding sites [ion binding]; other site 370438002538 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 370438002539 dimer interface [polypeptide binding]; other site 370438002540 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 370438002541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 370438002542 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 370438002543 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 370438002544 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 370438002545 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 370438002546 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 370438002547 nucleotide binding site/active site [active] 370438002548 HIT family signature motif; other site 370438002549 catalytic residue [active] 370438002550 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 370438002551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002552 FeS/SAM binding site; other site 370438002553 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438002554 YabP family; Region: YabP; cl06766 370438002555 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 370438002556 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 370438002557 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 370438002558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002559 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 370438002560 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 370438002561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438002562 Zn2+ binding site [ion binding]; other site 370438002563 Mg2+ binding site [ion binding]; other site 370438002564 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 370438002565 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 370438002566 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 370438002567 active site 370438002568 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 370438002569 active site 370438002570 catalytic motif [active] 370438002571 Zn binding site [ion binding]; other site 370438002572 GTPase Era; Reviewed; Region: era; PRK00089 370438002573 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 370438002574 G1 box; other site 370438002575 GTP/Mg2+ binding site [chemical binding]; other site 370438002576 Switch I region; other site 370438002577 G2 box; other site 370438002578 Switch II region; other site 370438002579 G3 box; other site 370438002580 G4 box; other site 370438002581 G5 box; other site 370438002582 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 370438002583 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 370438002584 Flavoprotein; Region: Flavoprotein; cl08021 370438002585 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 370438002586 Recombination protein O N terminal; Region: RecO_N; cl15812 370438002587 Recombination protein O C terminal; Region: RecO_C; pfam02565 370438002588 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 370438002589 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 370438002590 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 370438002591 dimer interface [polypeptide binding]; other site 370438002592 motif 1; other site 370438002593 active site 370438002594 motif 2; other site 370438002595 motif 3; other site 370438002596 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 370438002597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438002598 Helix-turn-helix domains; Region: HTH; cl00088 370438002599 FOG: CBS domain [General function prediction only]; Region: COG0517 370438002600 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 370438002601 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 370438002602 pyruvate phosphate dikinase; Provisional; Region: PRK09279 370438002603 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 370438002604 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 370438002605 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 370438002606 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 370438002607 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 370438002608 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 370438002609 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 370438002610 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 370438002611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438002612 Zn2+ binding site [ion binding]; other site 370438002613 Mg2+ binding site [ion binding]; other site 370438002614 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 370438002615 DNA primase; Validated; Region: dnaG; PRK05667 370438002616 CHC2 zinc finger; Region: zf-CHC2; cl15369 370438002617 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 370438002618 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 370438002619 active site 370438002620 metal binding site [ion binding]; metal-binding site 370438002621 interdomain interaction site; other site 370438002622 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 370438002623 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 370438002624 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 370438002625 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 370438002626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438002627 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 370438002628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438002629 DNA binding residues [nucleotide binding] 370438002630 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 370438002631 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438002632 glutamine synthetase, type I; Region: GlnA; TIGR00653 370438002633 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 370438002634 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370438002635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002636 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370438002637 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370438002638 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370438002639 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 370438002640 Putative zinc ribbon domain; Region: DUF164; pfam02591 370438002641 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 370438002642 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 370438002643 nudix motif; other site 370438002644 NAD synthetase; Provisional; Region: PRK13981 370438002645 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 370438002646 multimer interface [polypeptide binding]; other site 370438002647 active site 370438002648 catalytic triad [active] 370438002649 protein interface 1 [polypeptide binding]; other site 370438002650 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 370438002651 Ligand Binding Site [chemical binding]; other site 370438002652 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 370438002653 intersubunit interface [polypeptide binding]; other site 370438002654 active site 370438002655 Zn2+ binding site [ion binding]; other site 370438002656 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438002657 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438002658 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438002659 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 370438002660 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926 370438002661 putative active site [active] 370438002662 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 370438002663 dimer interface [polypeptide binding]; other site 370438002664 substrate binding site [chemical binding]; other site 370438002665 ATP binding site [chemical binding]; other site 370438002666 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438002667 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 370438002668 GTP-binding protein YchF; Reviewed; Region: PRK09601 370438002669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002670 G1 box; other site 370438002671 GTP/Mg2+ binding site [chemical binding]; other site 370438002672 G2 box; other site 370438002673 Switch I region; other site 370438002674 G3 box; other site 370438002675 Switch II region; other site 370438002676 G4 box; other site 370438002677 G5 box; other site 370438002678 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 370438002679 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 370438002680 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 370438002681 S-layer homology domain; Region: SLH; pfam00395 370438002682 S-layer homology domain; Region: SLH; pfam00395 370438002683 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 370438002684 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 370438002685 putative dimer interface [polypeptide binding]; other site 370438002686 active site pocket [active] 370438002687 putative cataytic base [active] 370438002688 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 370438002689 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438002690 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 370438002691 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain [General function prediction only]; Region: COG1782 370438002692 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438002693 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 370438002694 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 370438002695 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438002696 YcfA-like protein; Region: YcfA; cl00752 370438002697 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 370438002698 Protein export membrane protein; Region: SecD_SecF; cl14618 370438002699 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 370438002700 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 370438002701 peptide binding site [polypeptide binding]; other site 370438002702 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 370438002703 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 370438002704 Metal-binding active site; metal-binding site 370438002705 AP (apurinic/apyrimidinic) site pocket; other site 370438002706 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 370438002707 spermidine synthase; Provisional; Region: PRK00811 370438002708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 370438002709 Arginase family; Region: Arginase; cl00306 370438002710 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370438002711 phosphate binding site [ion binding]; other site 370438002712 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370438002713 Uncharacterized conserved protein [Function unknown]; Region: COG1284 370438002714 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370438002715 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 370438002716 Cobalt transport protein; Region: CbiQ; cl00463 370438002717 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 370438002718 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438002719 Walker A/P-loop; other site 370438002720 ATP binding site [chemical binding]; other site 370438002721 Q-loop/lid; other site 370438002722 ABC transporter signature motif; other site 370438002723 Walker B; other site 370438002724 D-loop; other site 370438002725 H-loop/switch region; other site 370438002726 CbiD; Region: CbiD; cl00828 370438002727 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438002728 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 370438002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 370438002730 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 370438002731 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438002732 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 370438002733 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438002734 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 370438002735 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 370438002736 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 370438002737 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 370438002738 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 370438002739 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438002740 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 370438002741 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 370438002742 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 370438002743 putative active site [active] 370438002744 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 370438002745 cobyric acid synthase; Provisional; Region: PRK00784 370438002746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002747 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002748 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 370438002749 catalytic triad [active] 370438002750 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 370438002751 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 370438002752 catalytic triad [active] 370438002753 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 370438002754 ATP phosphoribosyltransferase; Region: HisG; cl15266 370438002755 HisG, C-terminal domain; Region: HisG_C; cl06867 370438002756 Uncharacterized conserved protein [Function unknown]; Region: COG1751 370438002757 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 370438002758 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 370438002759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002761 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 370438002762 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 370438002763 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 370438002764 putative active site [active] 370438002765 catalytic site [active] 370438002766 putative metal binding site [ion binding]; other site 370438002767 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 370438002768 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438002769 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438002770 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 370438002771 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 370438002772 substrate binding pocket [chemical binding]; other site 370438002773 chain length determination region; other site 370438002774 substrate-Mg2+ binding site; other site 370438002775 catalytic residues [active] 370438002776 aspartate-rich region 1; other site 370438002777 active site lid residues [active] 370438002778 aspartate-rich region 2; other site 370438002779 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 370438002780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002781 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 370438002782 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 370438002783 tRNA; other site 370438002784 putative tRNA binding site [nucleotide binding]; other site 370438002785 putative NADP binding site [chemical binding]; other site 370438002786 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 370438002787 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 370438002788 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 370438002789 domain interfaces; other site 370438002790 active site 370438002791 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370438002792 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 370438002793 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 370438002794 active site 370438002795 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 370438002796 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 370438002797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002798 FeS/SAM binding site; other site 370438002799 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438002800 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 370438002801 dimer interface [polypeptide binding]; other site 370438002802 active site 370438002803 Schiff base residues; other site 370438002804 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 370438002805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002806 FeS/SAM binding site; other site 370438002807 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438002808 Helix-turn-helix domains; Region: HTH; cl00088 370438002809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 370438002810 Helix-turn-helix domains; Region: HTH; cl00088 370438002811 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 370438002812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 370438002813 inhibitor-cofactor binding pocket; inhibition site 370438002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438002815 catalytic residue [active] 370438002816 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 370438002817 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 370438002818 Aspartase; Region: Aspartase; cd01357 370438002819 active sites [active] 370438002820 tetramer interface [polypeptide binding]; other site 370438002821 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 370438002822 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 370438002823 G1 box; other site 370438002824 GTP/Mg2+ binding site [chemical binding]; other site 370438002825 Switch I region; other site 370438002826 G2 box; other site 370438002827 Switch II region; other site 370438002828 G3 box; other site 370438002829 G4 box; other site 370438002830 G5 box; other site 370438002831 biotin synthase; Provisional; Region: PRK07094 370438002832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002833 FeS/SAM binding site; other site 370438002834 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 370438002835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002836 FeS/SAM binding site; other site 370438002837 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 370438002838 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 370438002839 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 370438002840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002841 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 370438002842 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 370438002843 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 370438002844 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 370438002845 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 370438002846 active site 370438002847 nucleophile elbow; other site 370438002848 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 370438002849 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 370438002850 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 370438002851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438002852 FeS/SAM binding site; other site 370438002853 Helix-turn-helix domains; Region: HTH; cl00088 370438002854 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 370438002855 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 370438002856 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438002857 Zn2+ binding site [ion binding]; other site 370438002858 Mg2+ binding site [ion binding]; other site 370438002859 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438002860 Zn2+ binding site [ion binding]; other site 370438002861 Mg2+ binding site [ion binding]; other site 370438002862 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 370438002863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002864 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 370438002865 Putative Fe-S cluster; Region: FeS; pfam04060 370438002866 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 370438002867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 370438002868 catalytic loop [active] 370438002869 iron binding site [ion binding]; other site 370438002870 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 370438002871 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 370438002872 substrate binding pocket [chemical binding]; other site 370438002873 dimer interface [polypeptide binding]; other site 370438002874 inhibitor binding site; inhibition site 370438002875 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 370438002876 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 370438002877 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 370438002878 FAD binding site [chemical binding]; other site 370438002879 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 370438002880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002881 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 370438002882 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 370438002883 active site 370438002884 metal-binding site [ion binding] 370438002885 nucleotide-binding site [chemical binding]; other site 370438002886 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 370438002887 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 370438002888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002889 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370438002890 Walker A motif; other site 370438002891 ATP binding site [chemical binding]; other site 370438002892 Walker B motif; other site 370438002893 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438002894 putative peptidoglycan binding site; other site 370438002895 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 370438002896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002897 Asp23 family; Region: Asp23; cl00574 370438002898 Transglycosylase; Region: Transgly; cl07896 370438002899 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 370438002900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438002901 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 370438002902 putative active site pocket [active] 370438002903 dimerization interface [polypeptide binding]; other site 370438002904 putative catalytic residue [active] 370438002905 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 370438002906 Iron-sulfur protein interface; other site 370438002907 proximal heme binding site [chemical binding]; other site 370438002908 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 370438002909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438002910 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 370438002911 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 370438002912 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 370438002913 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007 370438002914 SxDxEG motif; other site 370438002915 active site 370438002916 metal binding site [ion binding]; metal-binding site 370438002917 homopentamer interface [polypeptide binding]; other site 370438002918 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 370438002919 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 370438002920 active site 370438002921 HIGH motif; other site 370438002922 dimer interface [polypeptide binding]; other site 370438002923 KMSKS motif; other site 370438002924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370438002925 RNA binding surface [nucleotide binding]; other site 370438002926 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 370438002927 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 370438002928 CoenzymeA binding site [chemical binding]; other site 370438002929 subunit interaction site [polypeptide binding]; other site 370438002930 PHB binding site; other site 370438002931 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438002932 putative peptidoglycan binding site; other site 370438002933 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 370438002934 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438002935 putative peptidoglycan binding site; other site 370438002936 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 370438002937 Transcriptional regulator; Region: Transcrip_reg; cl00361 370438002938 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 370438002939 active site 370438002940 putative DNA-binding cleft [nucleotide binding]; other site 370438002941 dimer interface [polypeptide binding]; other site 370438002942 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 370438002943 RuvA N terminal domain; Region: RuvA_N; pfam01330 370438002944 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 370438002945 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 370438002946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438002947 Walker A motif; other site 370438002948 ATP binding site [chemical binding]; other site 370438002949 Walker B motif; other site 370438002950 arginine finger; other site 370438002951 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 370438002952 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 370438002953 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 370438002954 Stage II sporulation protein; Region: SpoIID; pfam08486 370438002955 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 370438002956 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 370438002957 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 370438002958 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 370438002959 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 370438002960 Preprotein translocase subunit; Region: YajC; cl00806 370438002961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438002962 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 370438002963 Protein export membrane protein; Region: SecD_SecF; cl14618 370438002964 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 370438002965 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 370438002966 Protein export membrane protein; Region: SecD_SecF; cl14618 370438002967 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 370438002968 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 370438002969 Ligand Binding Site [chemical binding]; other site 370438002970 Bifunctional nuclease; Region: DNase-RNase; cl00553 370438002971 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 370438002972 Cation efflux family; Region: Cation_efflux; cl00316 370438002973 Helix-turn-helix domains; Region: HTH; cl00088 370438002974 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 370438002975 DHH family; Region: DHH; pfam01368 370438002976 DHHA1 domain; Region: DHHA1; pfam02272 370438002977 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 370438002978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438002979 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 370438002980 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438002981 active site 370438002982 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 370438002983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438002984 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 370438002985 synthetase active site [active] 370438002986 NTP binding site [chemical binding]; other site 370438002987 metal binding site [ion binding]; metal-binding site 370438002988 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 370438002989 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 370438002990 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 370438002991 putative active site [active] 370438002992 dimerization interface [polypeptide binding]; other site 370438002993 putative tRNAtyr binding site [nucleotide binding]; other site 370438002994 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438002995 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 370438002996 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 370438002997 dimer interface [polypeptide binding]; other site 370438002998 motif 1; other site 370438002999 active site 370438003000 motif 2; other site 370438003001 motif 3; other site 370438003002 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 370438003003 anticodon binding site; other site 370438003004 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 370438003005 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 370438003006 dimer interface [polypeptide binding]; other site 370438003007 anticodon binding site; other site 370438003008 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 370438003009 homodimer interface [polypeptide binding]; other site 370438003010 motif 1; other site 370438003011 active site 370438003012 motif 2; other site 370438003013 GAD domain; Region: GAD; pfam02938 370438003014 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 370438003015 motif 3; other site 370438003016 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 370438003017 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 370438003018 putative ATP binding site [chemical binding]; other site 370438003019 putative substrate interface [chemical binding]; other site 370438003020 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 370438003021 catalytic residues [active] 370438003022 recombination factor protein RarA; Reviewed; Region: PRK13342 370438003023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438003024 Walker A motif; other site 370438003025 ATP binding site [chemical binding]; other site 370438003026 Walker B motif; other site 370438003027 arginine finger; other site 370438003028 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 370438003029 Helix-turn-helix domains; Region: HTH; cl00088 370438003030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370438003031 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 370438003032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370438003033 catalytic residue [active] 370438003034 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 370438003035 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 370438003036 trimerization site [polypeptide binding]; other site 370438003037 active site 370438003038 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 370438003039 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 370438003040 Ligand Binding Site [chemical binding]; other site 370438003041 Domain of unknown function DUF20; Region: UPF0118; pfam01594 370438003042 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 370438003043 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 370438003044 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 370438003045 motif 1; other site 370438003046 active site 370438003047 motif 2; other site 370438003048 motif 3; other site 370438003049 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 370438003050 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 370438003051 DHHA1 domain; Region: DHHA1; pfam02272 370438003052 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 370438003053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370438003054 Coenzyme A binding pocket [chemical binding]; other site 370438003055 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 370438003056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 370438003057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 370438003058 active site 370438003059 catalytic tetrad [active] 370438003060 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 370438003061 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 370438003062 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 370438003063 VanW like protein; Region: VanW; pfam04294 370438003064 G5 domain; Region: G5; pfam07501 370438003065 YceG-like family; Region: YceG; pfam02618 370438003066 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 370438003067 dimerization interface [polypeptide binding]; other site 370438003068 putative protease; Provisional; Region: PRK15452 370438003069 Peptidase family U32; Region: Peptidase_U32; cl03113 370438003070 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 370438003071 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 370438003072 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438003073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 370438003074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438003075 non-specific DNA binding site [nucleotide binding]; other site 370438003076 salt bridge; other site 370438003077 sequence-specific DNA binding site [nucleotide binding]; other site 370438003078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438003079 non-specific DNA binding site [nucleotide binding]; other site 370438003080 salt bridge; other site 370438003081 sequence-specific DNA binding site [nucleotide binding]; other site 370438003082 transcriptional repressor DicA; Reviewed; Region: PRK09706 370438003083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438003084 non-specific DNA binding site [nucleotide binding]; other site 370438003085 salt bridge; other site 370438003086 sequence-specific DNA binding site [nucleotide binding]; other site 370438003087 Short C-terminal domain; Region: SHOCT; cl01373 370438003088 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 370438003089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438003090 S-adenosylmethionine binding site [chemical binding]; other site 370438003091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003092 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 370438003093 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 370438003094 NAD(P) binding site [chemical binding]; other site 370438003095 homodimer interface [polypeptide binding]; other site 370438003096 substrate binding site [chemical binding]; other site 370438003097 active site 370438003098 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 370438003099 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 370438003100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003101 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 370438003102 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 370438003103 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 370438003104 substrate binding site; other site 370438003105 metal-binding site 370438003106 Oligomer interface; other site 370438003107 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 370438003108 Cupin domain; Region: Cupin_2; cl09118 370438003109 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 370438003110 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 370438003111 NADP binding site [chemical binding]; other site 370438003112 active site 370438003113 putative substrate binding site [chemical binding]; other site 370438003114 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 370438003115 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 370438003116 NAD binding site [chemical binding]; other site 370438003117 substrate binding site [chemical binding]; other site 370438003118 homodimer interface [polypeptide binding]; other site 370438003119 active site 370438003120 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438003121 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 370438003122 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 370438003123 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 370438003124 Probable Catalytic site; other site 370438003125 metal-binding site 370438003126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003127 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 370438003128 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 370438003129 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 370438003130 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 370438003131 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 370438003132 active site residue [active] 370438003133 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 370438003134 active site residue [active] 370438003135 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 370438003136 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 370438003137 active site residue [active] 370438003138 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 370438003139 active site residue [active] 370438003140 Bacterial SH3 domain; Region: SH3_3; cl02551 370438003141 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 370438003142 Chain length determinant protein; Region: Wzz; cl15801 370438003143 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 370438003144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438003145 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 370438003146 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 370438003147 NAD binding site [chemical binding]; other site 370438003148 substrate binding site [chemical binding]; other site 370438003149 homodimer interface [polypeptide binding]; other site 370438003150 active site 370438003151 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 370438003152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438003153 putative ADP-binding pocket [chemical binding]; other site 370438003154 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 370438003155 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 370438003156 putative ADP-binding pocket [chemical binding]; other site 370438003157 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 370438003158 putative active site [active] 370438003159 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370438003160 Bacterial sugar transferase; Region: Bac_transf; cl00939 370438003161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 370438003162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003163 NAD(P) binding site [chemical binding]; other site 370438003164 active site 370438003165 Right handed beta helix region; Region: Beta_helix; pfam13229 370438003166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 370438003167 Interdomain contacts; other site 370438003168 Cytokine receptor motif; other site 370438003169 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 370438003170 active site 370438003171 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 370438003172 homodimer interface [polypeptide binding]; other site 370438003173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438003174 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370438003175 O-Antigen ligase; Region: Wzy_C; cl04850 370438003176 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 370438003177 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 370438003178 putative ADP-binding pocket [chemical binding]; other site 370438003179 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 370438003180 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 370438003181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438003182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 370438003183 putative trimer interface [polypeptide binding]; other site 370438003184 putative CoA binding site [chemical binding]; other site 370438003185 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 370438003186 putative trimer interface [polypeptide binding]; other site 370438003187 putative active site [active] 370438003188 putative substrate binding site [chemical binding]; other site 370438003189 putative CoA binding site [chemical binding]; other site 370438003190 Chain length determinant protein; Region: Wzz; cl15801 370438003191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 370438003192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003193 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 370438003194 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 370438003195 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 370438003196 inhibitor-cofactor binding pocket; inhibition site 370438003197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438003198 catalytic residue [active] 370438003199 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 370438003200 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 370438003201 inhibitor-cofactor binding pocket; inhibition site 370438003202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438003203 catalytic residue [active] 370438003204 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 370438003205 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 370438003206 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 370438003207 putative metal binding site; other site 370438003208 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 370438003209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 370438003210 binding surface 370438003211 TPR motif; other site 370438003212 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 370438003213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 370438003214 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 370438003215 putative metal binding site; other site 370438003216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 370438003217 binding surface 370438003218 TPR motif; other site 370438003219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 370438003220 binding surface 370438003221 TPR repeat; Region: TPR_11; pfam13414 370438003222 TPR motif; other site 370438003223 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 370438003224 putative metal binding site; other site 370438003225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 370438003226 TPR motif; other site 370438003227 binding surface 370438003228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438003229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438003230 active site 370438003231 sporulation sigma factor SigK; Reviewed; Region: PRK05803 370438003232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438003233 DNA binding residues [nucleotide binding] 370438003234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003236 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 370438003237 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370438003238 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 370438003239 catalytic residues [active] 370438003240 catalytic nucleophile [active] 370438003241 Recombinase; Region: Recombinase; pfam07508 370438003242 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370438003243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438003244 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 370438003245 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 370438003246 GTP binding site; other site 370438003247 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 370438003248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370438003249 active site 370438003250 motif I; other site 370438003251 motif II; other site 370438003252 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 370438003253 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 370438003254 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 370438003255 NAD(P) binding site [chemical binding]; other site 370438003256 shikimate binding site; other site 370438003257 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 370438003258 Tetramer interface [polypeptide binding]; other site 370438003259 active site 370438003260 FMN-binding site [chemical binding]; other site 370438003261 shikimate kinase; Provisional; Region: PRK13947 370438003262 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 370438003263 ADP binding site [chemical binding]; other site 370438003264 magnesium binding site [ion binding]; other site 370438003265 putative shikimate binding site; other site 370438003266 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 370438003267 active site 370438003268 dimer interface [polypeptide binding]; other site 370438003269 metal binding site [ion binding]; metal-binding site 370438003270 DDE superfamily endonuclease; Region: DDE_5; cl02413 370438003271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438003272 Type II/IV secretion system protein; Region: T2SE; pfam00437 370438003273 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 370438003274 Walker A motif; other site 370438003275 ATP binding site [chemical binding]; other site 370438003276 Walker B motif; other site 370438003277 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 370438003278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438003279 Walker A motif; other site 370438003280 ATP binding site [chemical binding]; other site 370438003281 Walker B motif; other site 370438003282 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 370438003283 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370438003284 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370438003285 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 370438003286 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 370438003287 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 370438003288 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 370438003289 Pilus assembly protein, PilO; Region: PilO; cl01234 370438003290 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 370438003291 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 370438003292 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 370438003293 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 370438003294 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 370438003295 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 370438003296 Walker A motif; other site 370438003297 ATP binding site [chemical binding]; other site 370438003298 Walker B motif; other site 370438003299 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 370438003300 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 370438003301 Walker A motif; other site 370438003302 ATP binding site [chemical binding]; other site 370438003303 Walker B motif; other site 370438003304 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 370438003305 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370438003306 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370438003307 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 370438003308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438003309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438003310 DNA binding residues [nucleotide binding] 370438003311 Competence protein A; Region: Competence_A; pfam11104 370438003312 Pilus assembly protein, PilO; Region: PilO; cl01234 370438003313 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 370438003314 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 370438003315 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 370438003316 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 370438003317 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 370438003318 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 370438003319 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 370438003320 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 370438003321 trimer interface [polypeptide binding]; other site 370438003322 active site 370438003323 dimer interface [polypeptide binding]; other site 370438003324 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 370438003325 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 370438003326 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 370438003327 active site 370438003328 elongation factor P; Validated; Region: PRK00529 370438003329 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 370438003330 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 370438003331 RNA binding site [nucleotide binding]; other site 370438003332 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 370438003333 RNA binding site [nucleotide binding]; other site 370438003334 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 370438003335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370438003336 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 370438003337 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 370438003338 active site residue [active] 370438003339 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 370438003340 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 370438003341 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 370438003342 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 370438003343 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 370438003344 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 370438003345 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 370438003346 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 370438003347 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 370438003348 pyruvate carboxylase subunit B; Validated; Region: PRK09282 370438003349 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 370438003350 active site 370438003351 catalytic residues [active] 370438003352 metal binding site [ion binding]; metal-binding site 370438003353 homodimer binding site [polypeptide binding]; other site 370438003354 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 370438003355 carboxyltransferase (CT) interaction site; other site 370438003356 biotinylation site [posttranslational modification]; other site 370438003357 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 370438003358 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370438003359 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438003360 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 370438003361 Asp23 family; Region: Asp23; cl00574 370438003362 Asp23 family; Region: Asp23; cl00574 370438003363 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 370438003364 putative RNA binding site [nucleotide binding]; other site 370438003365 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 370438003366 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 370438003367 FAD binding pocket [chemical binding]; other site 370438003368 FAD binding motif [chemical binding]; other site 370438003369 phosphate binding motif [ion binding]; other site 370438003370 beta-alpha-beta structure motif; other site 370438003371 NAD binding pocket [chemical binding]; other site 370438003372 Iron coordination center [ion binding]; other site 370438003373 putative oxidoreductase; Provisional; Region: PRK12831 370438003374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003376 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 370438003377 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 370438003378 generic binding surface II; other site 370438003379 generic binding surface I; other site 370438003380 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370438003381 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 370438003382 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 370438003383 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 370438003384 homodimer interface [polypeptide binding]; other site 370438003385 NADP binding site [chemical binding]; other site 370438003386 substrate binding site [chemical binding]; other site 370438003387 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 370438003388 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 370438003389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 370438003390 inhibitor-cofactor binding pocket; inhibition site 370438003391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438003392 catalytic residue [active] 370438003393 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 370438003394 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 370438003395 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 370438003396 LamB/YcsF family; Region: LamB_YcsF; cl00664 370438003397 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 370438003398 carboxyltransferase (CT) interaction site; other site 370438003399 biotinylation site [posttranslational modification]; other site 370438003400 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 370438003401 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370438003402 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438003403 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 370438003404 PAS domain; Region: PAS_9; pfam13426 370438003405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438003406 putative active site [active] 370438003407 heme pocket [chemical binding]; other site 370438003408 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 370438003409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438003410 Walker A motif; other site 370438003411 ATP binding site [chemical binding]; other site 370438003412 Walker B motif; other site 370438003413 arginine finger; other site 370438003414 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 370438003415 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 370438003416 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 370438003417 substrate binding pocket [chemical binding]; other site 370438003418 chain length determination region; other site 370438003419 substrate-Mg2+ binding site; other site 370438003420 catalytic residues [active] 370438003421 aspartate-rich region 1; other site 370438003422 active site lid residues [active] 370438003423 aspartate-rich region 2; other site 370438003424 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 370438003425 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 370438003426 TPP-binding site; other site 370438003427 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 370438003428 PYR/PP interface [polypeptide binding]; other site 370438003429 dimer interface [polypeptide binding]; other site 370438003430 TPP binding site [chemical binding]; other site 370438003431 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 370438003432 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 370438003433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370438003434 RNA binding surface [nucleotide binding]; other site 370438003435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 370438003436 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 370438003437 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 370438003438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003440 arginine repressor; Provisional; Region: PRK04280 370438003441 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 370438003442 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 370438003443 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 370438003444 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 370438003445 Walker A/P-loop; other site 370438003446 ATP binding site [chemical binding]; other site 370438003447 Q-loop/lid; other site 370438003448 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 370438003449 ABC transporter signature motif; other site 370438003450 Walker B; other site 370438003451 D-loop; other site 370438003452 H-loop/switch region; other site 370438003453 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 370438003454 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 370438003455 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 370438003456 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 370438003457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438003458 active site 370438003459 phosphorylation site [posttranslational modification] 370438003460 intermolecular recognition site; other site 370438003461 dimerization interface [polypeptide binding]; other site 370438003462 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 370438003463 Ferredoxin [Energy production and conversion]; Region: COG1146 370438003464 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438003465 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 370438003466 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 370438003467 dimer interface [polypeptide binding]; other site 370438003468 PYR/PP interface [polypeptide binding]; other site 370438003469 TPP binding site [chemical binding]; other site 370438003470 substrate binding site [chemical binding]; other site 370438003471 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 370438003472 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 370438003473 TPP-binding site [chemical binding]; other site 370438003474 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 370438003475 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 370438003476 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 370438003477 peptidase T-like protein; Region: PepT-like; TIGR01883 370438003478 metal binding site [ion binding]; metal-binding site 370438003479 putative dimer interface [polypeptide binding]; other site 370438003480 Integral membrane protein DUF95; Region: DUF95; cl00572 370438003481 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 370438003482 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 370438003483 active site 370438003484 Int/Topo IB signature motif; other site 370438003485 Sulfatase; Region: Sulfatase; cl10460 370438003486 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 370438003487 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 370438003488 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 370438003489 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 370438003490 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 370438003491 Transposase domain (DUF772); Region: DUF772; cl15789 370438003492 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438003493 Transposase domain (DUF772); Region: DUF772; cl15789 370438003494 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 370438003495 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 370438003496 putative NTP binding site [chemical binding]; other site 370438003497 Helix-turn-helix domains; Region: HTH; cl00088 370438003498 Integrase core domain; Region: rve; cl01316 370438003499 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 370438003500 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 370438003501 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 370438003502 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438003503 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 370438003504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438003505 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 370438003506 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 370438003507 anti sigma factor interaction site; other site 370438003508 regulatory phosphorylation site [posttranslational modification]; other site 370438003509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438003510 ATP binding site [chemical binding]; other site 370438003511 Mg2+ binding site [ion binding]; other site 370438003512 G-X-G motif; other site 370438003513 sporulation sigma factor SigF; Validated; Region: PRK05572 370438003514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438003515 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 370438003516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438003517 DNA binding residues [nucleotide binding] 370438003518 Dodecin; Region: Dodecin; cl01328 370438003519 SpoVA protein; Region: SpoVA; cl04298 370438003520 stage V sporulation protein AD; Validated; Region: PRK08304 370438003521 stage V sporulation protein AD; Provisional; Region: PRK12404 370438003522 SpoVA protein; Region: SpoVA; cl04298 370438003523 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 370438003524 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 370438003525 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 370438003526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 370438003527 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 370438003528 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370438003529 diaminopimelate decarboxylase; Region: lysA; TIGR01048 370438003530 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 370438003531 active site 370438003532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 370438003533 substrate binding site [chemical binding]; other site 370438003534 catalytic residues [active] 370438003535 dimer interface [polypeptide binding]; other site 370438003536 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 370438003537 DHH family; Region: DHH; pfam01368 370438003538 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 370438003539 FOG: CBS domain [General function prediction only]; Region: COG0517 370438003540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 370438003541 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 370438003542 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 370438003543 active site 370438003544 NTP binding site [chemical binding]; other site 370438003545 metal binding triad [ion binding]; metal-binding site 370438003546 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 370438003547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438003548 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 370438003549 active site 370438003550 putative substrate binding region [chemical binding]; other site 370438003551 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 370438003552 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 370438003553 active site 370438003554 HIGH motif; other site 370438003555 dimer interface [polypeptide binding]; other site 370438003556 KMSKS motif; other site 370438003557 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 370438003558 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 370438003559 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 370438003560 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 370438003561 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 370438003562 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 370438003563 putative DNA binding site [nucleotide binding]; other site 370438003564 putative homodimer interface [polypeptide binding]; other site 370438003565 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 370438003566 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 370438003567 active site 370438003568 DNA binding site [nucleotide binding] 370438003569 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 370438003570 DNA binding site [nucleotide binding] 370438003571 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 370438003572 nucleotide binding site [chemical binding]; other site 370438003573 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 370438003574 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 370438003575 DNA topoisomerase I; Validated; Region: PRK05582 370438003576 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 370438003577 active site 370438003578 interdomain interaction site; other site 370438003579 putative metal-binding site [ion binding]; other site 370438003580 nucleotide binding site [chemical binding]; other site 370438003581 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 370438003582 domain I; other site 370438003583 DNA binding groove [nucleotide binding] 370438003584 phosphate binding site [ion binding]; other site 370438003585 domain II; other site 370438003586 domain III; other site 370438003587 nucleotide binding site [chemical binding]; other site 370438003588 catalytic site [active] 370438003589 domain IV; other site 370438003590 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 370438003591 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 370438003592 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 370438003593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438003595 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438003596 active site 370438003597 DNA binding site [nucleotide binding] 370438003598 Int/Topo IB signature motif; other site 370438003599 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 370438003600 active site 370438003601 HslU subunit interaction site [polypeptide binding]; other site 370438003602 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 370438003603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438003604 Walker A motif; other site 370438003605 ATP binding site [chemical binding]; other site 370438003606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438003607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370438003608 transcriptional repressor CodY; Validated; Region: PRK04158 370438003609 CodY GAF-like domain; Region: CodY; pfam06018 370438003610 Helix-turn-helix domains; Region: HTH; cl00088 370438003611 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 370438003612 rRNA interaction site [nucleotide binding]; other site 370438003613 S8 interaction site; other site 370438003614 putative laminin-1 binding site; other site 370438003615 elongation factor Ts; Reviewed; Region: tsf; PRK12332 370438003616 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 370438003617 Elongation factor TS; Region: EF_TS; pfam00889 370438003618 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 370438003619 putative nucleotide binding site [chemical binding]; other site 370438003620 uridine monophosphate binding site [chemical binding]; other site 370438003621 homohexameric interface [polypeptide binding]; other site 370438003622 ribosome recycling factor; Reviewed; Region: frr; PRK00083 370438003623 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 370438003624 hinge region; other site 370438003625 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438003626 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 370438003627 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 370438003628 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 370438003629 catalytic residue [active] 370438003630 putative FPP diphosphate binding site; other site 370438003631 putative FPP binding hydrophobic cleft; other site 370438003632 dimer interface [polypeptide binding]; other site 370438003633 putative IPP diphosphate binding site; other site 370438003634 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 370438003635 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 370438003636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 370438003637 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 370438003638 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 370438003639 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 370438003640 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 370438003641 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 370438003642 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 370438003643 active site 370438003644 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 370438003645 protein binding site [polypeptide binding]; other site 370438003646 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 370438003647 putative substrate binding region [chemical binding]; other site 370438003648 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 370438003649 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 370438003650 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 370438003651 prolyl-tRNA synthetase; Provisional; Region: PRK09194 370438003652 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 370438003653 dimer interface [polypeptide binding]; other site 370438003654 motif 1; other site 370438003655 active site 370438003656 motif 2; other site 370438003657 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 370438003658 putative deacylase active site [active] 370438003659 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 370438003660 active site 370438003661 motif 3; other site 370438003662 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 370438003663 anticodon binding site; other site 370438003664 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 370438003665 monogalactosyldiacylglycerol synthase; Region: PLN02605 370438003666 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438003667 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 370438003668 ribosome maturation protein RimP; Reviewed; Region: PRK00092 370438003669 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 370438003670 Sm1 motif; other site 370438003671 predicted subunit interaction site [polypeptide binding]; other site 370438003672 RNA binding pocket [nucleotide binding]; other site 370438003673 Sm2 motif; other site 370438003674 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 370438003675 NusA N-terminal domain; Region: NusA_N; pfam08529 370438003676 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 370438003677 RNA binding site [nucleotide binding]; other site 370438003678 homodimer interface [polypeptide binding]; other site 370438003679 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 370438003680 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 370438003681 G-X-X-G motif; other site 370438003682 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 370438003683 putative RNA binding cleft [nucleotide binding]; other site 370438003684 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 370438003685 translation initiation factor IF-2; Validated; Region: infB; PRK05306 370438003686 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 370438003687 translation initiation factor IF-2; Validated; Region: infB; PRK05306 370438003688 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 370438003689 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 370438003690 G1 box; other site 370438003691 putative GEF interaction site [polypeptide binding]; other site 370438003692 GTP/Mg2+ binding site [chemical binding]; other site 370438003693 Switch I region; other site 370438003694 G2 box; other site 370438003695 G3 box; other site 370438003696 Switch II region; other site 370438003697 G4 box; other site 370438003698 G5 box; other site 370438003699 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 370438003700 Translation-initiation factor 2; Region: IF-2; pfam11987 370438003701 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 370438003702 Ribosome-binding factor A; Region: RBFA; cl00542 370438003703 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 370438003704 DHH family; Region: DHH; pfam01368 370438003705 DHHA1 domain; Region: DHHA1; pfam02272 370438003706 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 370438003707 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 370438003708 RNA binding site [nucleotide binding]; other site 370438003709 active site 370438003710 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 370438003711 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 370438003712 active site 370438003713 Riboflavin kinase; Region: Flavokinase; cl03312 370438003714 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 370438003715 16S/18S rRNA binding site [nucleotide binding]; other site 370438003716 S13e-L30e interaction site [polypeptide binding]; other site 370438003717 25S rRNA binding site [nucleotide binding]; other site 370438003718 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 370438003719 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 370438003720 RNase E interface [polypeptide binding]; other site 370438003721 trimer interface [polypeptide binding]; other site 370438003722 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 370438003723 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 370438003724 RNase E interface [polypeptide binding]; other site 370438003725 trimer interface [polypeptide binding]; other site 370438003726 active site 370438003727 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 370438003728 putative nucleic acid binding region [nucleotide binding]; other site 370438003729 G-X-X-G motif; other site 370438003730 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 370438003731 RNA binding site [nucleotide binding]; other site 370438003732 domain interface; other site 370438003733 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 370438003734 NodB motif; other site 370438003735 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 370438003736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438003737 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 370438003738 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 370438003739 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 370438003740 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 370438003741 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 370438003742 trimer interface [polypeptide binding]; other site 370438003743 active site 370438003744 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370438003745 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 370438003746 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 370438003747 active site 370438003748 dihydrodipicolinate reductase; Provisional; Region: PRK00048 370438003749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003750 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 370438003751 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 370438003752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003753 Flavoprotein; Region: Flavoprotein; cl08021 370438003754 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 370438003755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003756 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 370438003757 aspartate kinase I; Reviewed; Region: PRK08210 370438003758 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 370438003759 nucleotide binding site [chemical binding]; other site 370438003760 substrate binding site [chemical binding]; other site 370438003761 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 370438003762 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 370438003763 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 370438003764 dihydrodipicolinate synthase; Region: dapA; TIGR00674 370438003765 dimer interface [polypeptide binding]; other site 370438003766 active site 370438003767 catalytic residue [active] 370438003768 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 370438003769 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438003770 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 370438003771 Clp protease; Region: CLP_protease; pfam00574 370438003772 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 370438003773 active site 370438003774 YlzJ-like protein; Region: YlzJ; pfam14035 370438003775 Bacitracin resistance protein BacA; Region: BacA; cl00858 370438003776 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 370438003777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438003778 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 370438003779 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 370438003780 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 370438003781 active site residue [active] 370438003782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438003783 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 370438003784 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 370438003785 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 370438003786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438003787 FeS/SAM binding site; other site 370438003788 TRAM domain; Region: TRAM; cl01282 370438003789 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 370438003790 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 370438003791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438003792 Walker A motif; other site 370438003793 ATP binding site [chemical binding]; other site 370438003794 Walker B motif; other site 370438003795 arginine finger; other site 370438003796 Peptidase family M41; Region: Peptidase_M41; pfam01434 370438003797 competence damage-inducible protein A; Provisional; Region: PRK00549 370438003798 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 370438003799 putative MPT binding site; other site 370438003800 Competence-damaged protein; Region: CinA; cl00666 370438003801 recombinase A; Provisional; Region: recA; PRK09354 370438003802 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 370438003803 hexamer interface [polypeptide binding]; other site 370438003804 Walker A motif; other site 370438003805 ATP binding site [chemical binding]; other site 370438003806 Walker B motif; other site 370438003807 phosphodiesterase; Provisional; Region: PRK12704 370438003808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438003809 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 370438003810 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 370438003811 putative active site [active] 370438003812 metal binding site [ion binding]; metal-binding site 370438003813 homodimer binding site [polypeptide binding]; other site 370438003814 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 370438003815 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 370438003816 active site 370438003817 dimer interface [polypeptide binding]; other site 370438003818 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 370438003819 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 370438003820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438003821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438003822 homodimer interface [polypeptide binding]; other site 370438003823 catalytic residue [active] 370438003824 proteasome-activating nucleotidase; Provisional; Region: PRK03992 370438003825 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 370438003826 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 370438003827 homotrimer interface [polypeptide binding]; other site 370438003828 Walker A motif; other site 370438003829 GTP binding site [chemical binding]; other site 370438003830 Walker B motif; other site 370438003831 CobD/Cbib protein; Region: CobD_Cbib; cl00561 370438003832 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 370438003833 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 370438003834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438003835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438003836 homodimer interface [polypeptide binding]; other site 370438003837 catalytic residue [active] 370438003838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370438003839 catalytic core [active] 370438003840 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 370438003841 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 370438003842 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370438003843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 370438003844 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 370438003845 active site 370438003846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370438003847 Coenzyme A binding pocket [chemical binding]; other site 370438003848 conserved hypothetical protein; Region: TIGR02231 370438003849 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 370438003850 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 370438003851 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 370438003852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370438003853 catalytic residue [active] 370438003854 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 370438003855 homodimer interface [polypeptide binding]; other site 370438003856 Walker A motif; other site 370438003857 ATP binding site [chemical binding]; other site 370438003858 hydroxycobalamin binding site [chemical binding]; other site 370438003859 Walker B motif; other site 370438003860 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370438003861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 370438003862 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 370438003863 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 370438003864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 370438003865 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 370438003866 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 370438003867 putative dimer interface [polypeptide binding]; other site 370438003868 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 370438003869 dimer interface [polypeptide binding]; other site 370438003870 active site 370438003871 ADP-ribose binding site [chemical binding]; other site 370438003872 nudix motif; other site 370438003873 metal binding site [ion binding]; metal-binding site 370438003874 septum formation inhibitor; Reviewed; Region: minC; PRK00513 370438003875 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 370438003876 ADP-glucose phosphorylase; Region: PLN02643 370438003877 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 370438003878 nucleotide binding site/active site [active] 370438003879 HIT family signature motif; other site 370438003880 catalytic residue [active] 370438003881 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438003882 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438003883 Domain of unknown function (DUF362); Region: DUF362; pfam04015 370438003884 Asp23 family; Region: Asp23; cl00574 370438003885 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 370438003886 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 370438003887 Ligand Binding Site [chemical binding]; other site 370438003888 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 370438003889 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 370438003890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438003891 FeS/SAM binding site; other site 370438003892 TRAM domain; Region: TRAM; cl01282 370438003893 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 370438003894 MutS domain I; Region: MutS_I; pfam01624 370438003895 MutS domain II; Region: MutS_II; pfam05188 370438003896 MutS family domain IV; Region: MutS_IV; pfam05190 370438003897 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 370438003898 Walker A/P-loop; other site 370438003899 ATP binding site [chemical binding]; other site 370438003900 Q-loop/lid; other site 370438003901 ABC transporter signature motif; other site 370438003902 Walker B; other site 370438003903 D-loop; other site 370438003904 H-loop/switch region; other site 370438003905 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 370438003906 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 370438003907 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 370438003908 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 370438003909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438003910 ATP binding site [chemical binding]; other site 370438003911 Mg2+ binding site [ion binding]; other site 370438003912 G-X-G motif; other site 370438003913 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 370438003914 ATP binding site [chemical binding]; other site 370438003915 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 370438003916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438003918 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 370438003919 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 370438003920 Sm1 motif; other site 370438003921 intra - hexamer interaction site; other site 370438003922 inter - hexamer interaction site [polypeptide binding]; other site 370438003923 nucleotide binding pocket [chemical binding]; other site 370438003924 Sm2 motif; other site 370438003925 stage V sporulation protein K; Region: spore_V_K; TIGR02881 370438003926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438003927 Walker A motif; other site 370438003928 ATP binding site [chemical binding]; other site 370438003929 Walker B motif; other site 370438003930 arginine finger; other site 370438003931 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 370438003932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370438003933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370438003934 catalytic residue [active] 370438003935 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 370438003936 Helix-turn-helix domains; Region: HTH; cl00088 370438003937 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 370438003938 putative dimerization interface [polypeptide binding]; other site 370438003939 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 370438003940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438003941 putative active site [active] 370438003942 heme pocket [chemical binding]; other site 370438003943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438003944 ATP binding site [chemical binding]; other site 370438003945 Mg2+ binding site [ion binding]; other site 370438003946 G-X-G motif; other site 370438003947 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 370438003948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438003949 active site 370438003950 phosphorylation site [posttranslational modification] 370438003951 intermolecular recognition site; other site 370438003952 dimerization interface [polypeptide binding]; other site 370438003953 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 370438003954 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 370438003955 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438003956 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 370438003957 MULE transposase domain; Region: MULE; pfam10551 370438003958 LexA repressor; Validated; Region: PRK00215 370438003959 Helix-turn-helix domains; Region: HTH; cl00088 370438003960 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 370438003961 Catalytic site [active] 370438003962 Transposase domain (DUF772); Region: DUF772; cl15789 370438003963 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438003964 putative CheW interface [polypeptide binding]; other site 370438003965 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438003966 Transposase domain (DUF772); Region: DUF772; cl15789 370438003967 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 370438003968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438003969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438003970 Walker A motif; other site 370438003971 ATP binding site [chemical binding]; other site 370438003972 Walker B motif; other site 370438003973 arginine finger; other site 370438003974 Helix-turn-helix domains; Region: HTH; cl00088 370438003975 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 370438003976 Fumarase C-terminus; Region: Fumerase_C; cl00795 370438003977 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 370438003978 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438003979 CoA-ligase; Region: Ligase_CoA; cl02894 370438003980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438003981 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 370438003982 CoA-ligase; Region: Ligase_CoA; cl02894 370438003983 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 370438003984 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 370438003985 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 370438003986 B12 binding site [chemical binding]; other site 370438003987 cobalt ligand [ion binding]; other site 370438003988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 370438003989 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 370438003990 dimer interface [polypeptide binding]; other site 370438003991 substrate binding site [chemical binding]; other site 370438003992 metal binding site [ion binding]; metal-binding site 370438003993 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 370438003994 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370438003995 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370438003996 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 370438003997 carboxyltransferase (CT) interaction site; other site 370438003998 biotinylation site [posttranslational modification]; other site 370438003999 malate dehydrogenase; Reviewed; Region: PRK06223 370438004000 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 370438004001 NAD(P) binding site [chemical binding]; other site 370438004002 dimer interface [polypeptide binding]; other site 370438004003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370438004004 substrate binding site [chemical binding]; other site 370438004005 oxaloacetate decarboxylase; Provisional; Region: PRK12331 370438004006 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 370438004007 active site 370438004008 catalytic residues [active] 370438004009 metal binding site [ion binding]; metal-binding site 370438004010 homodimer binding site [polypeptide binding]; other site 370438004011 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 370438004012 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 370438004013 dimer interface [polypeptide binding]; other site 370438004014 PYR/PP interface [polypeptide binding]; other site 370438004015 TPP binding site [chemical binding]; other site 370438004016 substrate binding site [chemical binding]; other site 370438004017 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 370438004018 Domain of unknown function; Region: EKR; cl11037 370438004019 4Fe-4S binding domain; Region: Fer4; cl02805 370438004020 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 370438004021 TPP-binding site [chemical binding]; other site 370438004022 dimer interface [polypeptide binding]; other site 370438004023 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 370438004024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438004025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 370438004026 putative substrate translocation pore; other site 370438004027 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438004028 nodulation ABC transporter NodI; Provisional; Region: PRK13537 370438004029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004030 Walker A/P-loop; other site 370438004031 ATP binding site [chemical binding]; other site 370438004032 Q-loop/lid; other site 370438004033 ABC transporter signature motif; other site 370438004034 Walker B; other site 370438004035 D-loop; other site 370438004036 H-loop/switch region; other site 370438004037 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 370438004038 AMP-binding enzyme; Region: AMP-binding; cl15778 370438004039 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 370438004040 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 370438004041 catalytic loop [active] 370438004042 iron binding site [ion binding]; other site 370438004043 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 370438004044 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 370438004045 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 370438004046 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 370438004047 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 370438004048 dimer interface [polypeptide binding]; other site 370438004049 [2Fe-2S] cluster binding site [ion binding]; other site 370438004050 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 370438004051 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 370438004052 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 370438004053 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 370438004054 4Fe-4S binding domain; Region: Fer4; cl02805 370438004055 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 370438004056 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 370438004057 putative dimer interface [polypeptide binding]; other site 370438004058 [2Fe-2S] cluster binding site [ion binding]; other site 370438004059 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 370438004060 ABC-ATPase subunit interface; other site 370438004061 dimer interface [polypeptide binding]; other site 370438004062 putative PBP binding regions; other site 370438004063 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370438004064 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 370438004065 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 370438004066 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 370438004067 metal binding site [ion binding]; metal-binding site 370438004068 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 370438004069 metal binding site 2 [ion binding]; metal-binding site 370438004070 putative DNA binding helix; other site 370438004071 metal binding site 1 [ion binding]; metal-binding site 370438004072 dimer interface [polypeptide binding]; other site 370438004073 structural Zn2+ binding site [ion binding]; other site 370438004074 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 370438004075 putative ADP-binding pocket [chemical binding]; other site 370438004076 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438004077 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 370438004078 active site 370438004079 ADP/pyrophosphate binding site [chemical binding]; other site 370438004080 dimerization interface [polypeptide binding]; other site 370438004081 allosteric effector site; other site 370438004082 fructose-1,6-bisphosphate binding site; other site 370438004083 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 370438004084 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 370438004085 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438004086 MULE transposase domain; Region: MULE; pfam10551 370438004087 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 370438004088 intersubunit interface [polypeptide binding]; other site 370438004089 active site 370438004090 catalytic residue [active] 370438004091 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 370438004092 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 370438004093 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 370438004094 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438004095 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 370438004096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438004097 active site 370438004098 DNA binding site [nucleotide binding] 370438004099 Int/Topo IB signature motif; other site 370438004100 Helix-turn-helix domains; Region: HTH; cl00088 370438004101 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 370438004102 polymerase nucleotide-binding site; other site 370438004103 DNA-binding residues [nucleotide binding]; DNA binding site 370438004104 nucleotide binding site [chemical binding]; other site 370438004105 primase nucleotide-binding site [nucleotide binding]; other site 370438004106 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 370438004107 AAA domain; Region: AAA_25; pfam13481 370438004108 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120 370438004109 ATP binding site [chemical binding]; other site 370438004110 Walker B motif; other site 370438004111 Repressor of nif and glnA expression [Transcription]; Region: COG1693 370438004112 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 370438004113 elongation factor G; Reviewed; Region: PRK12740 370438004114 G1 box; other site 370438004115 putative GEF interaction site [polypeptide binding]; other site 370438004116 GTP/Mg2+ binding site [chemical binding]; other site 370438004117 Switch I region; other site 370438004118 G2 box; other site 370438004119 G3 box; other site 370438004120 Switch II region; other site 370438004121 G4 box; other site 370438004122 G5 box; other site 370438004123 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 370438004124 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 370438004125 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 370438004126 stage V sporulation protein B; Region: spore_V_B; TIGR02900 370438004127 MatE; Region: MatE; cl10513 370438004128 MatE; Region: MatE; cl10513 370438004129 Survival protein SurE; Region: SurE; cl00448 370438004130 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 370438004131 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 370438004132 homodecamer interface [polypeptide binding]; other site 370438004133 GTP cyclohydrolase I; Provisional; Region: PLN03044 370438004134 active site 370438004135 putative catalytic site residues [active] 370438004136 zinc binding site [ion binding]; other site 370438004137 GTP-CH-I/GFRP interaction surface; other site 370438004138 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 370438004139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438004140 FeS/SAM binding site; other site 370438004141 Domain of unknown function (DUF366); Region: DUF366; cl00890 370438004142 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 370438004143 Ligand Binding Site [chemical binding]; other site 370438004144 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 370438004145 active site 370438004146 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 370438004147 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 370438004148 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 370438004149 FAD binding pocket [chemical binding]; other site 370438004150 FAD binding motif [chemical binding]; other site 370438004151 phosphate binding motif [ion binding]; other site 370438004152 beta-alpha-beta structure motif; other site 370438004153 NAD binding pocket [chemical binding]; other site 370438004154 Iron coordination center [ion binding]; other site 370438004155 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 370438004156 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 370438004157 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438004158 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 370438004159 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 370438004160 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 370438004161 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 370438004162 4Fe-4S binding domain; Region: Fer4; cl02805 370438004163 4Fe-4S binding domain; Region: Fer4; cl02805 370438004164 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 370438004165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004166 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 370438004167 Cysteine-rich domain; Region: CCG; pfam02754 370438004168 Cysteine-rich domain; Region: CCG; pfam02754 370438004169 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438004170 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438004171 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 370438004172 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 370438004173 active site 370438004174 catalytic site [active] 370438004175 substrate binding site [chemical binding]; other site 370438004176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438004179 ArgK protein; Region: ArgK; pfam03308 370438004180 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 370438004181 Walker A; other site 370438004182 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 370438004183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370438004185 adenylate kinase; Reviewed; Region: adk; PRK00279 370438004186 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 370438004187 AMP-binding site [chemical binding]; other site 370438004188 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 370438004189 Family description; Region: VCBS; pfam13517 370438004190 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 370438004191 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 370438004192 putative dimer interface [polypeptide binding]; other site 370438004193 putative anticodon binding site; other site 370438004194 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 370438004195 homodimer interface [polypeptide binding]; other site 370438004196 motif 1; other site 370438004197 motif 2; other site 370438004198 active site 370438004199 motif 3; other site 370438004200 aspartate aminotransferase; Provisional; Region: PRK06836 370438004201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438004202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438004203 homodimer interface [polypeptide binding]; other site 370438004204 catalytic residue [active] 370438004205 PAS domain; Region: PAS_9; pfam13426 370438004206 PAS domain; Region: PAS_9; pfam13426 370438004207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438004208 putative active site [active] 370438004209 heme pocket [chemical binding]; other site 370438004210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438004211 PAS domain S-box; Region: sensory_box; TIGR00229 370438004212 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 370438004213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438004214 putative active site [active] 370438004215 heme pocket [chemical binding]; other site 370438004216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438004217 dimer interface [polypeptide binding]; other site 370438004218 phosphorylation site [posttranslational modification] 370438004219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438004220 ATP binding site [chemical binding]; other site 370438004221 Mg2+ binding site [ion binding]; other site 370438004222 G-X-G motif; other site 370438004223 Protein of unknown function (DUF456); Region: DUF456; cl01069 370438004224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 370438004225 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 370438004226 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 370438004227 active site 370438004228 metal binding site [ion binding]; metal-binding site 370438004229 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 370438004230 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 370438004231 G1 box; other site 370438004232 putative GEF interaction site [polypeptide binding]; other site 370438004233 GTP/Mg2+ binding site [chemical binding]; other site 370438004234 Switch I region; other site 370438004235 G2 box; other site 370438004236 G3 box; other site 370438004237 Switch II region; other site 370438004238 G4 box; other site 370438004239 G5 box; other site 370438004240 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 370438004241 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 370438004242 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 370438004243 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 370438004244 selenocysteine synthase; Provisional; Region: PRK04311 370438004245 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 370438004246 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370438004247 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 370438004248 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 370438004249 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 370438004250 dimerization interface [polypeptide binding]; other site 370438004251 ATP binding site [chemical binding]; other site 370438004252 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 370438004253 dimerization interface [polypeptide binding]; other site 370438004254 ATP binding site [chemical binding]; other site 370438004255 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 370438004256 putative active site [active] 370438004257 catalytic triad [active] 370438004258 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 370438004259 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 370438004260 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 370438004261 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438004262 active site 370438004263 DNA binding site [nucleotide binding] 370438004264 Int/Topo IB signature motif; other site 370438004265 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438004266 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438004267 active site 370438004268 DNA binding site [nucleotide binding] 370438004269 Int/Topo IB signature motif; other site 370438004270 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438004271 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 370438004272 MULE transposase domain; Region: MULE; pfam10551 370438004273 NMT1-like family; Region: NMT1_2; cl15260 370438004274 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 370438004275 UbiA prenyltransferase family; Region: UbiA; cl00337 370438004276 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 370438004277 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 370438004278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438004279 S-adenosylmethionine binding site [chemical binding]; other site 370438004280 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 370438004281 substrate binding pocket [chemical binding]; other site 370438004282 aspartate-rich region 1; other site 370438004283 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 370438004284 hypothetical protein; Provisional; Region: PRK13795 370438004285 Sensor protein DegS; Region: DegS; pfam05384 370438004286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 370438004287 Histidine kinase; Region: HisKA_3; pfam07730 370438004288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438004289 ATP binding site [chemical binding]; other site 370438004290 Mg2+ binding site [ion binding]; other site 370438004291 G-X-G motif; other site 370438004292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 370438004293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438004294 active site 370438004295 phosphorylation site [posttranslational modification] 370438004296 intermolecular recognition site; other site 370438004297 dimerization interface [polypeptide binding]; other site 370438004298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 370438004299 DNA binding residues [nucleotide binding] 370438004300 dimerization interface [polypeptide binding]; other site 370438004301 Flp/Fap pilin component; Region: Flp_Fap; cl01585 370438004302 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 370438004303 TadE-like protein; Region: TadE; cl10688 370438004304 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 370438004305 SAF domain; Region: SAF; cl00555 370438004306 Response regulator receiver domain; Region: Response_reg; pfam00072 370438004307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438004308 active site 370438004309 phosphorylation site [posttranslational modification] 370438004310 intermolecular recognition site; other site 370438004311 dimerization interface [polypeptide binding]; other site 370438004312 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 370438004313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004314 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 370438004315 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 370438004316 ATP binding site [chemical binding]; other site 370438004317 Walker A motif; other site 370438004318 hexamer interface [polypeptide binding]; other site 370438004319 Walker B motif; other site 370438004320 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370438004321 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370438004322 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 370438004323 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 370438004324 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 370438004325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438004326 dimerization interface [polypeptide binding]; other site 370438004327 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 370438004328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370438004329 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 370438004330 FtsX-like permease family; Region: FtsX; cl15850 370438004331 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370438004332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370438004333 Walker A/P-loop; other site 370438004334 ATP binding site [chemical binding]; other site 370438004335 Q-loop/lid; other site 370438004336 ABC transporter signature motif; other site 370438004337 Walker B; other site 370438004338 D-loop; other site 370438004339 H-loop/switch region; other site 370438004340 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 370438004341 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438004342 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 370438004343 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 370438004344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370438004345 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 370438004346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370438004347 motif II; other site 370438004348 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 370438004349 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 370438004350 SpoOM protein; Region: Spo0M; pfam07070 370438004351 Methyltransferase domain; Region: Methyltransf_31; pfam13847 370438004352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438004353 S-adenosylmethionine binding site [chemical binding]; other site 370438004354 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370438004355 Ion channel; Region: Ion_trans_2; cl11596 370438004356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004357 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 370438004358 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 370438004359 GtrA-like protein; Region: GtrA; cl00971 370438004360 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 370438004361 Ligand binding site; other site 370438004362 Putative Catalytic site; other site 370438004363 DXD motif; other site 370438004364 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438004365 MULE transposase domain; Region: MULE; pfam10551 370438004366 Ubiquitin-like proteins; Region: UBQ; cl00155 370438004367 charged pocket; other site 370438004368 hydrophobic patch; other site 370438004369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438004370 non-specific DNA binding site [nucleotide binding]; other site 370438004371 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 370438004372 salt bridge; other site 370438004373 sequence-specific DNA binding site [nucleotide binding]; other site 370438004374 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 370438004375 Catalytic site [active] 370438004376 Domain of unknown function DUF39; Region: DUF39; cl14897 370438004377 NIL domain; Region: NIL; cl09633 370438004378 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 370438004379 4Fe-4S binding domain; Region: Fer4; cl02805 370438004380 4Fe-4S binding domain; Region: Fer4; cl02805 370438004381 ApbE family; Region: ApbE; cl00643 370438004382 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438004383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004384 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 370438004385 Walker A/P-loop; other site 370438004386 ATP binding site [chemical binding]; other site 370438004387 Q-loop/lid; other site 370438004388 ABC transporter signature motif; other site 370438004389 Walker B; other site 370438004390 D-loop; other site 370438004391 H-loop/switch region; other site 370438004392 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 370438004393 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 370438004394 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438004395 Q-loop/lid; other site 370438004396 ABC transporter signature motif; other site 370438004397 Walker B; other site 370438004398 D-loop; other site 370438004399 H-loop/switch region; other site 370438004400 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 370438004401 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438004402 Walker A/P-loop; other site 370438004403 ATP binding site [chemical binding]; other site 370438004404 Q-loop/lid; other site 370438004405 ABC transporter signature motif; other site 370438004406 Walker B; other site 370438004407 D-loop; other site 370438004408 H-loop/switch region; other site 370438004409 Cobalt transport protein; Region: CbiQ; cl00463 370438004410 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 370438004411 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 370438004412 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 370438004413 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438004414 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 370438004415 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 370438004416 S-layer homology domain; Region: SLH; pfam00395 370438004417 S-layer homology domain; Region: SLH; pfam00395 370438004418 S-layer homology domain; Region: SLH; pfam00395 370438004419 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 370438004420 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 370438004421 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 370438004422 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 370438004423 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 370438004424 Walker A/P-loop; other site 370438004425 ATP binding site [chemical binding]; other site 370438004426 Q-loop/lid; other site 370438004427 ABC transporter signature motif; other site 370438004428 Walker B; other site 370438004429 D-loop; other site 370438004430 H-loop/switch region; other site 370438004431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 370438004432 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 370438004433 Walker A/P-loop; other site 370438004434 ATP binding site [chemical binding]; other site 370438004435 Q-loop/lid; other site 370438004436 ABC transporter signature motif; other site 370438004437 Walker B; other site 370438004438 D-loop; other site 370438004439 H-loop/switch region; other site 370438004440 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 370438004441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 370438004442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 370438004443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 370438004444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 370438004445 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 370438004446 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 370438004447 Methyltransferase domain; Region: Methyltransf_31; pfam13847 370438004448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438004449 S-adenosylmethionine binding site [chemical binding]; other site 370438004450 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 370438004451 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 370438004452 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 370438004453 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 370438004454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004455 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 370438004456 coenzyme F420 hydrogenase, subunit gamma; Region: FrhG; TIGR03294 370438004457 4Fe-4S binding domain; Region: Fer4; cl02805 370438004458 coenzyme F420-reducing hydrogenase subunit beta; Validated; Region: PRK09325 370438004459 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 370438004460 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 370438004461 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 370438004462 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 370438004463 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 370438004464 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 370438004465 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438004466 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438004467 DNA polymerase IV; Reviewed; Region: PRK03103 370438004468 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 370438004469 active site 370438004470 DNA binding site [nucleotide binding] 370438004471 Predicted integral membrane protein [Function unknown]; Region: COG5658 370438004472 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 370438004473 SdpI/YhfL protein family; Region: SdpI; pfam13630 370438004474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438004475 dimerization interface [polypeptide binding]; other site 370438004476 putative DNA binding site [nucleotide binding]; other site 370438004477 putative Zn2+ binding site [ion binding]; other site 370438004478 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 370438004479 putative oxidoreductase; Provisional; Region: PRK12831 370438004480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004481 putative oxidoreductase; Provisional; Region: PRK12831 370438004482 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 370438004483 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 370438004484 CPxP motif; other site 370438004485 DsrE/DsrF-like family; Region: DrsE; cl00672 370438004486 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 370438004487 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 370438004488 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 370438004489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004490 CoA-ligase; Region: Ligase_CoA; cl02894 370438004491 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438004492 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 370438004493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004494 DRTGG domain; Region: DRTGG; cl12147 370438004495 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 370438004496 CoenzymeA binding site [chemical binding]; other site 370438004497 subunit interaction site [polypeptide binding]; other site 370438004498 PHB binding site; other site 370438004499 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 370438004500 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370438004501 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 370438004502 FMN binding site [chemical binding]; other site 370438004503 dimer interface [polypeptide binding]; other site 370438004504 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 370438004505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 370438004506 Helix-turn-helix domains; Region: HTH; cl00088 370438004507 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 370438004508 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438004509 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004510 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 370438004511 Walker A/P-loop; other site 370438004512 ATP binding site [chemical binding]; other site 370438004513 Q-loop/lid; other site 370438004514 ABC transporter signature motif; other site 370438004515 Walker B; other site 370438004516 D-loop; other site 370438004517 H-loop/switch region; other site 370438004518 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 370438004519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004520 Walker A/P-loop; other site 370438004521 ATP binding site [chemical binding]; other site 370438004522 Q-loop/lid; other site 370438004523 ABC transporter signature motif; other site 370438004524 Walker B; other site 370438004525 D-loop; other site 370438004526 H-loop/switch region; other site 370438004527 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 370438004528 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 370438004529 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438004530 TRAM domain; Region: TRAM; cl01282 370438004531 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 370438004532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438004533 S-adenosylmethionine binding site [chemical binding]; other site 370438004534 DDE superfamily endonuclease; Region: DDE_5; cl02413 370438004535 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438004536 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 370438004537 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370438004538 ABC transporter; Region: ABC_tran_2; pfam12848 370438004539 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370438004540 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 370438004541 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 370438004542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 370438004544 Integrase core domain; Region: rve; cl01316 370438004545 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 370438004546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004547 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 370438004548 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 370438004549 Ligand binding site; other site 370438004550 metal-binding site 370438004551 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 370438004552 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 370438004553 XdhC Rossmann domain; Region: XdhC_C; pfam13478 370438004554 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 370438004555 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 370438004556 putative MPT binding site; other site 370438004557 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 370438004558 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 370438004559 transmembrane helices; other site 370438004560 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 370438004561 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 370438004562 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 370438004563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 370438004564 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 370438004565 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 370438004566 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 370438004567 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 370438004568 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 370438004569 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438004570 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438004571 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 370438004572 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370438004573 transmembrane helices; other site 370438004574 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 370438004575 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 370438004576 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370438004577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438004578 Walker A motif; other site 370438004579 ATP binding site [chemical binding]; other site 370438004580 Walker B motif; other site 370438004581 arginine finger; other site 370438004582 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 370438004583 AMP-binding enzyme; Region: AMP-binding; cl15778 370438004584 AMP-binding enzyme; Region: AMP-binding; cl15778 370438004585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 370438004586 Helix-turn-helix domains; Region: HTH; cl00088 370438004587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 370438004588 dimerization interface [polypeptide binding]; other site 370438004589 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 370438004590 AMP-binding domain protein; Validated; Region: PRK08315 370438004591 AMP-binding enzyme; Region: AMP-binding; cl15778 370438004592 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 370438004593 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 370438004594 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 370438004595 putative MPT binding site; other site 370438004596 Helix-turn-helix domains; Region: HTH; cl00088 370438004597 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 370438004598 Ligand binding site [chemical binding]; other site 370438004599 Electron transfer flavoprotein domain; Region: ETF; pfam01012 370438004600 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 370438004601 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 370438004602 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 370438004603 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 370438004604 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438004605 Cysteine-rich domain; Region: CCG; pfam02754 370438004606 Cysteine-rich domain; Region: CCG; pfam02754 370438004607 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 370438004608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438004609 FeS/SAM binding site; other site 370438004610 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 370438004611 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 370438004612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438004613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438004614 DNA binding residues [nucleotide binding] 370438004615 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 370438004616 Helix-turn-helix domains; Region: HTH; cl00088 370438004617 Integrase core domain; Region: rve; cl01316 370438004618 Integrase core domain; Region: rve_3; cl15866 370438004619 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438004620 MULE transposase domain; Region: MULE; pfam10551 370438004621 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438004622 HTH-like domain; Region: HTH_21; pfam13276 370438004623 Integrase core domain; Region: rve; cl01316 370438004624 Integrase core domain; Region: rve_3; cl15866 370438004625 Helix-turn-helix domains; Region: HTH; cl00088 370438004626 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 370438004627 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 370438004628 Helix-turn-helix domains; Region: HTH; cl00088 370438004629 HTH-like domain; Region: HTH_21; pfam13276 370438004630 Integrase core domain; Region: rve; cl01316 370438004631 Integrase core domain; Region: rve_3; cl15866 370438004632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438004633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438004634 active site 370438004635 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 370438004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438004637 putative substrate translocation pore; other site 370438004638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438004639 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438004640 active site 370438004641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438004642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438004643 active site 370438004644 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438004645 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438004646 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 370438004647 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 370438004648 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 370438004649 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 370438004650 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 370438004651 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 370438004652 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 370438004653 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 370438004654 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 370438004655 hypothetical protein; Reviewed; Region: PRK09588 370438004656 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 370438004657 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 370438004658 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 370438004659 putative catalytic cysteine [active] 370438004660 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 370438004661 putative active site [active] 370438004662 metal binding site [ion binding]; metal-binding site 370438004663 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 370438004664 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 370438004665 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 370438004666 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 370438004667 catalytic site [active] 370438004668 active site 370438004669 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 370438004670 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 370438004671 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 370438004672 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 370438004673 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 370438004674 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 370438004675 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 370438004676 active site 370438004677 catalytic site [active] 370438004678 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 370438004679 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 370438004680 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 370438004681 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 370438004682 active site 370438004683 dimer interface [polypeptide binding]; other site 370438004684 effector binding site; other site 370438004685 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 370438004686 response regulator;containing CheY-like receiver domain and AraC-type DNA-binding domain; interrupted by transposase 370438004687 Transposase [DNA replication, recombination, and repair]; Region: COG5421 370438004688 GAF domain; Region: GAF_2; pfam13185 370438004689 GAF domain; Region: GAF; cl15785 370438004690 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 370438004691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438004692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438004693 dimer interface [polypeptide binding]; other site 370438004694 phosphorylation site [posttranslational modification] 370438004695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438004696 ATP binding site [chemical binding]; other site 370438004697 Mg2+ binding site [ion binding]; other site 370438004698 G-X-G motif; other site 370438004699 Response regulator receiver domain; Region: Response_reg; pfam00072 370438004700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438004701 active site 370438004702 phosphorylation site [posttranslational modification] 370438004703 intermolecular recognition site; other site 370438004704 dimerization interface [polypeptide binding]; other site 370438004705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 370438004706 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 370438004707 Sulfatase; Region: Sulfatase; cl10460 370438004708 aspartate kinase; Reviewed; Region: PRK06635 370438004709 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 370438004710 putative catalytic residues [active] 370438004711 putative nucleotide binding site [chemical binding]; other site 370438004712 putative aspartate binding site [chemical binding]; other site 370438004713 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 370438004714 putative allosteric regulatory site; other site 370438004715 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 370438004716 putative allosteric regulatory residue; other site 370438004717 homoserine kinase; Provisional; Region: PRK01212 370438004718 homoserine dehydrogenase; Provisional; Region: PRK06349 370438004719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004720 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 370438004721 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 370438004722 hypothetical protein; Provisional; Region: PRK04435 370438004723 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 370438004724 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 370438004725 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 370438004726 catalytic residues [active] 370438004727 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 370438004728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004729 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 370438004730 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 370438004731 GTP-binding protein Der; Reviewed; Region: PRK00093 370438004732 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 370438004733 G1 box; other site 370438004734 GTP/Mg2+ binding site [chemical binding]; other site 370438004735 Switch I region; other site 370438004736 G2 box; other site 370438004737 Switch II region; other site 370438004738 G3 box; other site 370438004739 G4 box; other site 370438004740 G5 box; other site 370438004741 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 370438004742 G1 box; other site 370438004743 GTP/Mg2+ binding site [chemical binding]; other site 370438004744 Switch I region; other site 370438004745 G2 box; other site 370438004746 G3 box; other site 370438004747 Switch II region; other site 370438004748 G4 box; other site 370438004749 G5 box; other site 370438004750 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 370438004751 Protein of unknown function (DUF512); Region: DUF512; pfam04459 370438004752 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 370438004753 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 370438004754 YIEGIA protein; Region: YIEGIA; pfam14045 370438004755 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 370438004756 stage II sporulation protein P; Region: spore_II_P; TIGR02867 370438004757 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 370438004758 cytidylate kinase; Provisional; Region: cmk; PRK00023 370438004759 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 370438004760 CMP-binding site; other site 370438004761 The sites determining sugar specificity; other site 370438004762 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 370438004763 putative acyl-acceptor binding pocket; other site 370438004764 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 370438004765 LytB protein; Region: LYTB; cl00507 370438004766 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 370438004767 RNA binding site [nucleotide binding]; other site 370438004768 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 370438004769 RNA binding site [nucleotide binding]; other site 370438004770 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 370438004771 RNA binding site [nucleotide binding]; other site 370438004772 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 370438004773 RNA binding site [nucleotide binding]; other site 370438004774 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 370438004775 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 370438004776 hinge; other site 370438004777 active site 370438004778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004779 prephenate dehydrogenase; Validated; Region: PRK06545 370438004780 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 370438004781 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 370438004782 NeuB family; Region: NeuB; cl00496 370438004783 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 370438004784 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 370438004785 substrate binding site [chemical binding]; other site 370438004786 active site 370438004787 catalytic residues [active] 370438004788 heterodimer interface [polypeptide binding]; other site 370438004789 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 370438004790 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 370438004791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438004792 catalytic residue [active] 370438004793 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 370438004794 active site 370438004795 ribulose/triose binding site [chemical binding]; other site 370438004796 phosphate binding site [ion binding]; other site 370438004797 substrate (anthranilate) binding pocket [chemical binding]; other site 370438004798 product (indole) binding pocket [chemical binding]; other site 370438004799 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 370438004800 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 370438004801 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 370438004802 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 370438004803 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 370438004804 glutamine binding [chemical binding]; other site 370438004805 catalytic triad [active] 370438004806 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 370438004807 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 370438004808 chorismate binding enzyme; Region: Chorismate_bind; cl10555 370438004809 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 370438004810 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 370438004811 homotrimer interaction site [polypeptide binding]; other site 370438004812 active site 370438004813 HutP; Region: HutP; cl07944 370438004814 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 370438004815 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 370438004816 active site 370438004817 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 370438004818 putative active site [active] 370438004819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004821 Nucleoside recognition; Region: Gate; cl00486 370438004822 Nucleoside recognition; Region: Gate; cl00486 370438004823 Glucose inhibited division protein A; Region: GIDA; pfam01134 370438004824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004826 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 370438004827 SpoVR like protein; Region: SpoVR; pfam04293 370438004828 Uncharacterized conserved protein [Function unknown]; Region: COG2718 370438004829 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 370438004830 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 370438004831 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 370438004832 Sporulation and spore germination; Region: Germane; cl11253 370438004833 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 370438004834 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 370438004835 catalytic triad [active] 370438004836 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 370438004837 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370438004838 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 370438004839 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 370438004840 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 370438004841 active site 370438004842 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 370438004843 catalytic triad [active] 370438004844 conserved cis-peptide bond; other site 370438004845 Acylphosphatase; Region: Acylphosphatase; cl00551 370438004846 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 370438004847 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438004848 Walker A/P-loop; other site 370438004849 ATP binding site [chemical binding]; other site 370438004850 Q-loop/lid; other site 370438004851 ABC transporter signature motif; other site 370438004852 Walker B; other site 370438004853 D-loop; other site 370438004854 H-loop/switch region; other site 370438004855 Cobalt transport protein; Region: CbiQ; cl00463 370438004856 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 370438004857 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438004858 Walker A/P-loop; other site 370438004859 ATP binding site [chemical binding]; other site 370438004860 Q-loop/lid; other site 370438004861 ABC transporter signature motif; other site 370438004862 Walker B; other site 370438004863 D-loop; other site 370438004864 H-loop/switch region; other site 370438004865 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 370438004866 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370438004867 Walker A/P-loop; other site 370438004868 ATP binding site [chemical binding]; other site 370438004869 Q-loop/lid; other site 370438004870 ABC transporter signature motif; other site 370438004871 Walker B; other site 370438004872 D-loop; other site 370438004873 H-loop/switch region; other site 370438004874 Cobalt transport protein; Region: CbiQ; cl00463 370438004875 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 370438004876 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 370438004877 dimer interface [polypeptide binding]; other site 370438004878 PYR/PP interface [polypeptide binding]; other site 370438004879 TPP binding site [chemical binding]; other site 370438004880 substrate binding site [chemical binding]; other site 370438004881 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 370438004882 TPP-binding site; other site 370438004883 4Fe-4S binding domain; Region: Fer4; cl02805 370438004884 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 370438004885 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 370438004886 AMP-binding enzyme; Region: AMP-binding; cl15778 370438004887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438004888 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 370438004889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438004890 putative active site [active] 370438004891 heme pocket [chemical binding]; other site 370438004892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438004893 metal binding site [ion binding]; metal-binding site 370438004894 active site 370438004895 I-site; other site 370438004896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438004897 Zn2+ binding site [ion binding]; other site 370438004898 Mg2+ binding site [ion binding]; other site 370438004899 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 370438004900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004901 Family description; Region: UvrD_C_2; cl15862 370438004902 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370438004903 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 370438004904 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370438004905 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 370438004906 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 370438004907 active site 370438004908 metal binding site [ion binding]; metal-binding site 370438004909 DNA binding site [nucleotide binding] 370438004910 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 370438004911 Protein of unknown function (DUF441); Region: DUF441; cl01041 370438004912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438004913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438004914 active site 370438004915 phosphorylation site [posttranslational modification] 370438004916 intermolecular recognition site; other site 370438004917 dimerization interface [polypeptide binding]; other site 370438004918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438004919 DNA binding site [nucleotide binding] 370438004920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438004921 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 370438004922 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 370438004923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438004924 dimer interface [polypeptide binding]; other site 370438004925 conserved gate region; other site 370438004926 putative PBP binding loops; other site 370438004927 ABC-ATPase subunit interface; other site 370438004928 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 370438004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438004930 dimer interface [polypeptide binding]; other site 370438004931 conserved gate region; other site 370438004932 putative PBP binding loops; other site 370438004933 ABC-ATPase subunit interface; other site 370438004934 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 370438004935 PhoU domain; Region: PhoU; pfam01895 370438004936 PhoU domain; Region: PhoU; pfam01895 370438004937 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 370438004938 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 370438004939 Walker A/P-loop; other site 370438004940 ATP binding site [chemical binding]; other site 370438004941 Q-loop/lid; other site 370438004942 ABC transporter signature motif; other site 370438004943 Walker B; other site 370438004944 D-loop; other site 370438004945 H-loop/switch region; other site 370438004946 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 370438004947 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 370438004948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438004949 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 370438004950 histidinol dehydrogenase; Region: hisD; TIGR00069 370438004951 NAD binding site [chemical binding]; other site 370438004952 dimerization interface [polypeptide binding]; other site 370438004953 product binding site; other site 370438004954 substrate binding site [chemical binding]; other site 370438004955 zinc binding site [ion binding]; other site 370438004956 catalytic residues [active] 370438004957 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 370438004958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438004959 NAD(P) binding site [chemical binding]; other site 370438004960 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 370438004961 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 370438004962 Walker A/P-loop; other site 370438004963 ATP binding site [chemical binding]; other site 370438004964 Q-loop/lid; other site 370438004965 ABC transporter signature motif; other site 370438004966 Walker B; other site 370438004967 D-loop; other site 370438004968 H-loop/switch region; other site 370438004969 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 370438004970 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 370438004971 TM-ABC transporter signature motif; other site 370438004972 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 370438004973 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 370438004974 ligand binding site [chemical binding]; other site 370438004975 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 370438004976 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512 370438004977 active site 370438004978 dimer interface [polypeptide binding]; other site 370438004979 catalytic nucleophile [active] 370438004980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370438004981 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 370438004982 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370438004983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438004984 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 370438004985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438004986 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 370438004987 Catalytic site [active] 370438004988 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 370438004989 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 370438004990 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 370438004991 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 370438004992 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 370438004993 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 370438004994 Walker A motif; other site 370438004995 Acylphosphatase; Region: Acylphosphatase; cl00551 370438004996 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 370438004997 HypF finger; Region: zf-HYPF; pfam07503 370438004998 HypF finger; Region: zf-HYPF; pfam07503 370438004999 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 370438005000 HupF/HypC family; Region: HupF_HypC; cl00394 370438005001 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 370438005002 Hydrogenase formation hypA family; Region: HypD; cl12072 370438005003 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 370438005004 dimerization interface [polypeptide binding]; other site 370438005005 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 370438005006 ATP binding site [chemical binding]; other site 370438005007 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 370438005008 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 370438005009 putative substrate-binding site; other site 370438005010 nickel binding site [ion binding]; other site 370438005011 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 370438005012 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 370438005013 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 370438005014 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 370438005015 Polysulphide reductase, NrfD; Region: NrfD; cl01295 370438005016 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 370438005017 active site 1 [active] 370438005018 dimer interface [polypeptide binding]; other site 370438005019 hexamer interface [polypeptide binding]; other site 370438005020 active site 2 [active] 370438005021 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 370438005022 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 370438005023 catalytic triad [active] 370438005024 Restriction endonuclease; Region: Mrr_cat; cl00516 370438005025 Nop14-like family; Region: Nop14; pfam04147 370438005026 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 370438005027 RNA/DNA hybrid binding site [nucleotide binding]; other site 370438005028 active site 370438005029 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 370438005030 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 370438005031 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438005032 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438005033 molybdopterin cofactor binding site; other site 370438005034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438005035 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 370438005036 molybdopterin cofactor binding site; other site 370438005037 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 370438005038 Polysulphide reductase, NrfD; Region: NrfD; cl01295 370438005039 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 370438005040 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 370438005041 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 370438005042 GTP/Mg2+ binding site [chemical binding]; other site 370438005043 G4 box; other site 370438005044 G5 box; other site 370438005045 G1 box; other site 370438005046 Switch I region; other site 370438005047 G2 box; other site 370438005048 G3 box; other site 370438005049 Switch II region; other site 370438005050 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 370438005051 Catalytic site [active] 370438005052 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 370438005053 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 370438005054 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 370438005055 RimM N-terminal domain; Region: RimM; pfam01782 370438005056 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370438005057 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 370438005058 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 370438005059 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 370438005060 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 370438005061 signal recognition particle protein; Provisional; Region: PRK10867 370438005062 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 370438005063 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 370438005064 P loop; other site 370438005065 GTP binding site [chemical binding]; other site 370438005066 Signal peptide binding domain; Region: SRP_SPB; pfam02978 370438005067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438005068 DNA binding residues [nucleotide binding] 370438005069 acetylornithine aminotransferase; Provisional; Region: PRK02627 370438005070 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 370438005071 inhibitor-cofactor binding pocket; inhibition site 370438005072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438005073 catalytic residue [active] 370438005074 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 370438005075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438005076 dimerization interface [polypeptide binding]; other site 370438005077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438005078 metal binding site [ion binding]; metal-binding site 370438005079 active site 370438005080 I-site; other site 370438005081 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 370438005082 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 370438005083 active site 370438005084 putative substrate binding pocket [chemical binding]; other site 370438005085 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 370438005086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005087 oligomerization interface [polypeptide binding]; other site 370438005088 active site 370438005089 NAD+ binding site [chemical binding]; other site 370438005090 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 370438005091 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 370438005092 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370438005093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370438005094 dimerization interface [polypeptide binding]; other site 370438005095 putative DNA binding site [nucleotide binding]; other site 370438005096 putative Zn2+ binding site [ion binding]; other site 370438005097 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 370438005098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370438005099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 370438005100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 370438005101 active site residue [active] 370438005102 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 370438005103 CPxP motif; other site 370438005104 DsrE/DsrF-like family; Region: DrsE; cl00672 370438005105 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 370438005106 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 370438005107 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 370438005108 P loop; other site 370438005109 GTP binding site [chemical binding]; other site 370438005110 ribonuclease III; Reviewed; Region: rnc; PRK00102 370438005111 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 370438005112 dimerization interface [polypeptide binding]; other site 370438005113 active site 370438005114 metal binding site [ion binding]; metal-binding site 370438005115 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 370438005116 dsRNA binding site [nucleotide binding]; other site 370438005117 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 370438005118 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 370438005119 dimer interface [polypeptide binding]; other site 370438005120 active site 370438005121 Phosphopantetheine attachment site; Region: PP-binding; cl09936 370438005122 Phosphopantetheine attachment site; Region: PP-binding; cl09936 370438005123 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 370438005124 NAD(P) binding site [chemical binding]; other site 370438005125 homotetramer interface [polypeptide binding]; other site 370438005126 homodimer interface [polypeptide binding]; other site 370438005127 active site 370438005128 Acyl transferase domain; Region: Acyl_transf_1; cl08282 370438005129 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 370438005130 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 370438005131 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 370438005132 FMN binding site [chemical binding]; other site 370438005133 substrate binding site [chemical binding]; other site 370438005134 putative catalytic residue [active] 370438005135 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 370438005136 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 370438005137 dimer interface [polypeptide binding]; other site 370438005138 active site 370438005139 CoA binding pocket [chemical binding]; other site 370438005140 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 370438005141 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 370438005142 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 370438005143 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 370438005144 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 370438005145 Nucleoside recognition; Region: Gate; cl00486 370438005146 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 370438005147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005148 CoA-ligase; Region: Ligase_CoA; cl02894 370438005149 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438005150 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 370438005151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005152 DRTGG domain; Region: DRTGG; cl12147 370438005153 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 370438005154 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 370438005155 active site 370438005156 (T/H)XGH motif; other site 370438005157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438005158 S-adenosylmethionine binding site [chemical binding]; other site 370438005159 Germination protease; Region: Peptidase_A25; cl04057 370438005160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 370438005161 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 370438005162 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 370438005163 generic binding surface II; other site 370438005164 ssDNA binding site; other site 370438005165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438005166 ATP binding site [chemical binding]; other site 370438005167 putative Mg++ binding site [ion binding]; other site 370438005168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438005169 nucleotide binding region [chemical binding]; other site 370438005170 ATP-binding site [chemical binding]; other site 370438005171 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 370438005172 homopentamer interface [polypeptide binding]; other site 370438005173 active site 370438005174 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 370438005175 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 370438005176 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 370438005177 dimerization interface [polypeptide binding]; other site 370438005178 active site 370438005179 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 370438005180 Lumazine binding domain; Region: Lum_binding; pfam00677 370438005181 Lumazine binding domain; Region: Lum_binding; pfam00677 370438005182 diaminohydroxyphosphoribosylaminopyrimidine deaminase; Region: PLN02807 370438005183 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 370438005184 catalytic motif [active] 370438005185 Zn binding site [ion binding]; other site 370438005186 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 370438005187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438005188 dimer interface [polypeptide binding]; other site 370438005189 putative CheW interface [polypeptide binding]; other site 370438005190 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 370438005191 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 370438005192 active site 370438005193 (T/H)XGH motif; other site 370438005194 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 370438005195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438005196 putative substrate translocation pore; other site 370438005197 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 370438005198 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438005199 oxidoreductase; Provisional; Region: PRK10015 370438005200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005201 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 370438005202 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 370438005203 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 370438005204 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 370438005205 Ligand binding site [chemical binding]; other site 370438005206 Electron transfer flavoprotein domain; Region: ETF; pfam01012 370438005207 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438005208 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 370438005209 FAD binding site [chemical binding]; other site 370438005210 homotetramer interface [polypeptide binding]; other site 370438005211 substrate binding pocket [chemical binding]; other site 370438005212 catalytic base [active] 370438005213 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 370438005214 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 370438005215 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 370438005216 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438005217 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438005218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438005219 PAS domain; Region: PAS_9; pfam13426 370438005220 putative active site [active] 370438005221 heme pocket [chemical binding]; other site 370438005222 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 370438005223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438005224 Walker A motif; other site 370438005225 ATP binding site [chemical binding]; other site 370438005226 Walker B motif; other site 370438005227 arginine finger; other site 370438005228 Helix-turn-helix domains; Region: HTH; cl00088 370438005229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370438005230 DNA-binding site [nucleotide binding]; DNA binding site 370438005231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005232 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 370438005233 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 370438005234 active site 370438005235 metal binding site [ion binding]; metal-binding site 370438005236 Accessory gene regulator B; Region: AgrB; cl01873 370438005237 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 370438005238 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 370438005239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438005240 putative active site [active] 370438005241 heme pocket [chemical binding]; other site 370438005242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438005243 dimer interface [polypeptide binding]; other site 370438005244 phosphorylation site [posttranslational modification] 370438005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438005246 ATP binding site [chemical binding]; other site 370438005247 Mg2+ binding site [ion binding]; other site 370438005248 G-X-G motif; other site 370438005249 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 370438005250 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 370438005251 substrate binding site [chemical binding]; other site 370438005252 hexamer interface [polypeptide binding]; other site 370438005253 metal binding site [ion binding]; metal-binding site 370438005254 GTPase RsgA; Reviewed; Region: PRK00098 370438005255 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 370438005256 RNA binding site [nucleotide binding]; other site 370438005257 homodimer interface [polypeptide binding]; other site 370438005258 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 370438005259 GTPase/Zn-binding domain interface [polypeptide binding]; other site 370438005260 GTP/Mg2+ binding site [chemical binding]; other site 370438005261 G4 box; other site 370438005262 G5 box; other site 370438005263 G1 box; other site 370438005264 Switch I region; other site 370438005265 G2 box; other site 370438005266 G3 box; other site 370438005267 Switch II region; other site 370438005268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 370438005269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 370438005270 active site 370438005271 ATP binding site [chemical binding]; other site 370438005272 substrate binding site [chemical binding]; other site 370438005273 activation loop (A-loop); other site 370438005274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 370438005275 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 370438005276 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 370438005277 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 370438005278 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 370438005279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438005280 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 370438005281 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 370438005282 Protein phosphatase 2C; Region: PP2C; pfam00481 370438005283 active site 370438005284 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 370438005285 phosphopeptide binding site; other site 370438005286 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 370438005287 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 370438005288 phosphopeptide binding site; other site 370438005289 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 370438005290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438005291 FeS/SAM binding site; other site 370438005292 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 370438005293 putative RNA binding site [nucleotide binding]; other site 370438005294 16S rRNA methyltransferase B; Provisional; Region: PRK14902 370438005295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438005296 S-adenosylmethionine binding site [chemical binding]; other site 370438005297 Protein of unknown function DUF116; Region: DUF116; cl00800 370438005298 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 370438005299 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 370438005300 putative active site [active] 370438005301 substrate binding site [chemical binding]; other site 370438005302 putative cosubstrate binding site; other site 370438005303 catalytic site [active] 370438005304 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 370438005305 substrate binding site [chemical binding]; other site 370438005306 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 370438005307 active site 370438005308 catalytic residues [active] 370438005309 metal binding site [ion binding]; metal-binding site 370438005310 primosome assembly protein PriA; Validated; Region: PRK05580 370438005311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438005312 ATP binding site [chemical binding]; other site 370438005313 putative Mg++ binding site [ion binding]; other site 370438005314 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438005315 ATP-binding site [chemical binding]; other site 370438005316 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 370438005317 Flavoprotein; Region: Flavoprotein; cl08021 370438005318 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 370438005319 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 370438005320 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 370438005321 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 370438005322 catalytic site [active] 370438005323 G-X2-G-X-G-K; other site 370438005324 Domain of unknown function (DUF370); Region: DUF370; cl00898 370438005325 hypothetical protein; Provisional; Region: PRK11820 370438005326 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 370438005327 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 370438005328 aspartate aminotransferase; Provisional; Region: PRK05764 370438005329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438005330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438005331 homodimer interface [polypeptide binding]; other site 370438005332 catalytic residue [active] 370438005333 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 370438005334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438005335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438005336 homodimer interface [polypeptide binding]; other site 370438005337 catalytic residue [active] 370438005338 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 370438005339 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 370438005340 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 370438005341 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 370438005342 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 370438005343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370438005344 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 370438005345 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438005346 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 370438005347 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 370438005348 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 370438005349 Domain of unknown function (DUF814); Region: DUF814; pfam05670 370438005350 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 370438005351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438005352 active site 370438005353 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 370438005354 active site 370438005355 dimer interface [polypeptide binding]; other site 370438005356 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 370438005357 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 370438005358 heterodimer interface [polypeptide binding]; other site 370438005359 active site 370438005360 FMN binding site [chemical binding]; other site 370438005361 homodimer interface [polypeptide binding]; other site 370438005362 substrate binding site [chemical binding]; other site 370438005363 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 370438005364 FAD binding pocket [chemical binding]; other site 370438005365 FAD binding motif [chemical binding]; other site 370438005366 phosphate binding motif [ion binding]; other site 370438005367 beta-alpha-beta structure motif; other site 370438005368 NAD binding pocket [chemical binding]; other site 370438005369 Iron coordination center [ion binding]; other site 370438005370 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 370438005371 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 370438005372 IMP binding site; other site 370438005373 dimer interface [polypeptide binding]; other site 370438005374 interdomain contacts; other site 370438005375 partial ornithine binding site; other site 370438005376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370438005377 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 370438005378 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438005379 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 370438005380 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 370438005381 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370438005382 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438005383 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 370438005384 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 370438005385 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 370438005386 catalytic site [active] 370438005387 subunit interface [polypeptide binding]; other site 370438005388 dihydroorotase; Validated; Region: pyrC; PRK09357 370438005389 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370438005390 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 370438005391 active site 370438005392 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 370438005393 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 370438005394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438005396 active site 370438005397 Protein of unknown function (DUF342); Region: DUF342; pfam03961 370438005398 Protein of unknown function (DUF342); Region: DUF342; pfam03961 370438005399 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 370438005400 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 370438005401 Protein of unknown function (DUF441); Region: DUF441; cl01041 370438005402 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 370438005403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370438005404 RNA binding surface [nucleotide binding]; other site 370438005405 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 370438005406 active site 370438005407 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 370438005408 lipoprotein signal peptidase; Provisional; Region: PRK14787 370438005409 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 370438005410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370438005411 active site 370438005412 HIGH motif; other site 370438005413 nucleotide binding site [chemical binding]; other site 370438005414 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 370438005415 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 370438005416 active site 370438005417 KMSKS motif; other site 370438005418 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 370438005419 tRNA binding surface [nucleotide binding]; other site 370438005420 anticodon binding site; other site 370438005421 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 370438005422 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 370438005423 PAC2 family; Region: PAC2; cl00847 370438005424 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 370438005425 putative active site [active] 370438005426 putative CoA binding site [chemical binding]; other site 370438005427 nudix motif; other site 370438005428 metal binding site [ion binding]; metal-binding site 370438005429 DivIVA protein; Region: DivIVA; pfam05103 370438005430 DivIVA domain; Region: DivI1A_domain; TIGR03544 370438005431 Plant ATP synthase F0; Region: YMF19; cl07975 370438005432 YGGT family; Region: YGGT; cl00508 370438005433 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 370438005434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005435 Protein of unknown function (DUF552); Region: DUF552; cl00775 370438005436 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 370438005437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 370438005438 catalytic residue [active] 370438005439 HlyD family secretion protein; Region: HlyD_2; pfam12700 370438005440 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438005441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438005442 dimerization interface [polypeptide binding]; other site 370438005443 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 370438005444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438005445 putative active site [active] 370438005446 heme pocket [chemical binding]; other site 370438005447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438005448 dimer interface [polypeptide binding]; other site 370438005449 phosphorylation site [posttranslational modification] 370438005450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438005451 ATP binding site [chemical binding]; other site 370438005452 Mg2+ binding site [ion binding]; other site 370438005453 G-X-G motif; other site 370438005454 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 370438005455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438005456 active site 370438005457 phosphorylation site [posttranslational modification] 370438005458 intermolecular recognition site; other site 370438005459 dimerization interface [polypeptide binding]; other site 370438005460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438005461 DNA binding site [nucleotide binding] 370438005462 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 370438005463 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 370438005464 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 370438005465 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438005466 Beta-Casp domain; Region: Beta-Casp; cl12567 370438005467 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 370438005468 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438005469 putative peptidoglycan binding site; other site 370438005470 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 370438005471 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 370438005472 Spore germination protein; Region: Spore_permease; cl15802 370438005473 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 370438005474 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 370438005475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438005476 FeS/SAM binding site; other site 370438005477 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 370438005478 ATP cone domain; Region: ATP-cone; pfam03477 370438005479 Class III ribonucleotide reductase; Region: RNR_III; cd01675 370438005480 effector binding site; other site 370438005481 active site 370438005482 Zn binding site [ion binding]; other site 370438005483 glycine loop; other site 370438005484 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 370438005485 ATP cone domain; Region: ATP-cone; pfam03477 370438005486 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370438005487 sporulation sigma factor SigG; Reviewed; Region: PRK08215 370438005488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438005489 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 370438005490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438005491 DNA binding residues [nucleotide binding] 370438005492 sporulation sigma factor SigE; Reviewed; Region: PRK08301 370438005493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438005494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438005495 DNA binding residues [nucleotide binding] 370438005496 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 370438005497 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 370438005498 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 370438005499 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 370438005500 dimerization interface [polypeptide binding]; other site 370438005501 putative ATP binding site [chemical binding]; other site 370438005502 cell division protein FtsZ; Validated; Region: PRK09330 370438005503 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 370438005504 nucleotide binding site [chemical binding]; other site 370438005505 SulA interaction site; other site 370438005506 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 370438005507 Cell division protein FtsA; Region: FtsA; cl11496 370438005508 Cell division protein FtsA; Region: FtsA; cl11496 370438005509 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 370438005510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 370438005511 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370438005512 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 370438005513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 370438005514 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 370438005515 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 370438005516 Cell division protein FtsQ; Region: FtsQ; pfam03799 370438005517 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 370438005518 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 370438005519 hinge; other site 370438005520 active site 370438005521 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 370438005522 FAD binding domain; Region: FAD_binding_4; pfam01565 370438005523 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 370438005524 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 370438005525 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 370438005526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370438005527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370438005528 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 370438005529 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 370438005530 active site 370438005531 homodimer interface [polypeptide binding]; other site 370438005532 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 370438005533 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 370438005534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370438005535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370438005536 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 370438005537 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 370438005538 Mg++ binding site [ion binding]; other site 370438005539 putative catalytic motif [active] 370438005540 putative substrate binding site [chemical binding]; other site 370438005541 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 370438005542 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 370438005543 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370438005544 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370438005545 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 370438005546 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 370438005547 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370438005548 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370438005549 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 370438005550 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 370438005551 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438005552 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 370438005553 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 370438005554 Septum formation initiator; Region: DivIC; cl11433 370438005555 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 370438005556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005557 cell division protein MraZ; Reviewed; Region: PRK00326 370438005558 MraZ protein; Region: MraZ; pfam02381 370438005559 MraZ protein; Region: MraZ; pfam02381 370438005560 histidinol-phosphatase; Provisional; Region: PRK07328 370438005561 PHP-associated; Region: PHP_C; pfam13263 370438005562 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 370438005563 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 370438005564 metal binding site 2 [ion binding]; metal-binding site 370438005565 putative DNA binding helix; other site 370438005566 metal binding site 1 [ion binding]; metal-binding site 370438005567 dimer interface [polypeptide binding]; other site 370438005568 structural Zn2+ binding site [ion binding]; other site 370438005569 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 370438005570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438005571 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 370438005572 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 370438005573 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 370438005574 G1 box; other site 370438005575 GTP/Mg2+ binding site [chemical binding]; other site 370438005576 Switch I region; other site 370438005577 G2 box; other site 370438005578 G3 box; other site 370438005579 Switch II region; other site 370438005580 G4 box; other site 370438005581 G5 box; other site 370438005582 Nucleoside recognition; Region: Gate; cl00486 370438005583 Nucleoside recognition; Region: Gate; cl00486 370438005584 FeoA domain; Region: FeoA; cl00838 370438005585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 370438005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438005587 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 370438005588 NodB motif; other site 370438005589 putative active site [active] 370438005590 putative catalytic site [active] 370438005591 putative Zn binding site [ion binding]; other site 370438005592 FAD binding domain; Region: FAD_binding_4; pfam01565 370438005593 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 370438005594 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438005595 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438005596 Cysteine-rich domain; Region: CCG; pfam02754 370438005597 Cysteine-rich domain; Region: CCG; pfam02754 370438005598 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 370438005599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 370438005600 protein binding site [polypeptide binding]; other site 370438005601 AAA domain; Region: AAA_32; pfam13654 370438005602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005603 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370438005604 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 370438005605 TM-ABC transporter signature motif; other site 370438005606 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 370438005607 active site 370438005608 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 370438005609 AMP-binding enzyme; Region: AMP-binding; cl15778 370438005610 AMP-binding enzyme; Region: AMP-binding; cl15778 370438005611 HTH-like domain; Region: HTH_21; pfam13276 370438005612 Integrase core domain; Region: rve; cl01316 370438005613 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 370438005614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438005615 DNA binding residues [nucleotide binding] 370438005616 Integrase core domain; Region: rve; cl01316 370438005617 Integrase core domain; Region: rve_3; cl15866 370438005618 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 370438005619 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 370438005620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438005621 Walker A motif; other site 370438005622 ATP binding site [chemical binding]; other site 370438005623 Walker B motif; other site 370438005624 arginine finger; other site 370438005625 HTH-like domain; Region: HTH_21; pfam13276 370438005626 Helix-turn-helix domains; Region: HTH; cl00088 370438005627 Transposase domain (DUF772); Region: DUF772; cl15789 370438005628 Transposase domain (DUF772); Region: DUF772; cl15789 370438005629 Integrase core domain; Region: rve; cl01316 370438005630 Integrase core domain; Region: rve_3; cl15866 370438005631 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 370438005632 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 370438005633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438005634 Walker A motif; other site 370438005635 ATP binding site [chemical binding]; other site 370438005636 Walker B motif; other site 370438005637 arginine finger; other site 370438005638 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438005639 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438005640 active site 370438005641 DNA binding site [nucleotide binding] 370438005642 Int/Topo IB signature motif; other site 370438005643 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 370438005644 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 370438005645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438005646 active site 370438005647 DNA binding site [nucleotide binding] 370438005648 Int/Topo IB signature motif; other site 370438005649 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 370438005650 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 370438005651 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370438005652 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 370438005653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005654 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 370438005655 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 370438005656 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 370438005657 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 370438005658 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 370438005659 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 370438005660 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 370438005661 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 370438005662 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682 370438005663 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 370438005664 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 370438005665 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 370438005666 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 370438005667 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 370438005668 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 370438005669 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 370438005670 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 370438005671 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 370438005672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 370438005673 DNA binding residues [nucleotide binding] 370438005674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438005675 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438005676 putative peptidoglycan binding site; other site 370438005677 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438005678 putative peptidoglycan binding site; other site 370438005679 Transglycosylase; Region: Transgly; cl07896 370438005680 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 370438005681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438005682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005683 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 370438005684 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 370438005685 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 370438005686 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 370438005687 Walker A/P-loop; other site 370438005688 ATP binding site [chemical binding]; other site 370438005689 Q-loop/lid; other site 370438005690 ABC transporter signature motif; other site 370438005691 Walker B; other site 370438005692 D-loop; other site 370438005693 H-loop/switch region; other site 370438005694 Smr domain; Region: Smr; cl02619 370438005695 manganese transport transcriptional regulator; Provisional; Region: PRK03902 370438005696 Helix-turn-helix domains; Region: HTH; cl00088 370438005697 Nucleoside recognition; Region: Gate; cl00486 370438005698 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 370438005699 Nucleoside recognition; Region: Gate; cl00486 370438005700 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 370438005701 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 370438005702 G1 box; other site 370438005703 GTP/Mg2+ binding site [chemical binding]; other site 370438005704 Switch I region; other site 370438005705 G2 box; other site 370438005706 G3 box; other site 370438005707 Switch II region; other site 370438005708 G4 box; other site 370438005709 G5 box; other site 370438005710 FeoA domain; Region: FeoA; cl00838 370438005711 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 370438005712 Peptidase family U32; Region: Peptidase_U32; cl03113 370438005713 Collagenase; Region: DUF3656; pfam12392 370438005714 Peptidase family U32; Region: Peptidase_U32; cl03113 370438005715 Uncharacterized conserved protein [Function unknown]; Region: COG0327 370438005716 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370438005717 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 370438005718 active site 370438005719 DNA binding site [nucleotide binding] 370438005720 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 370438005721 hypothetical protein; Provisional; Region: PRK08609 370438005722 active site 370438005723 primer binding site [nucleotide binding]; other site 370438005724 NTP binding site [chemical binding]; other site 370438005725 metal binding triad [ion binding]; metal-binding site 370438005726 Cell division protein ZapA; Region: ZapA; cl01146 370438005727 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 370438005728 B3/4 domain; Region: B3_4; cl11458 370438005729 tRNA synthetase B5 domain; Region: B5; cl08394 370438005730 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 370438005731 dimer interface [polypeptide binding]; other site 370438005732 motif 1; other site 370438005733 motif 3; other site 370438005734 motif 2; other site 370438005735 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 370438005736 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 370438005737 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 370438005738 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 370438005739 dimer interface [polypeptide binding]; other site 370438005740 motif 1; other site 370438005741 active site 370438005742 motif 2; other site 370438005743 motif 3; other site 370438005744 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 370438005745 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 370438005746 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 370438005747 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 370438005748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438005749 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370438005750 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 370438005751 23S rRNA binding site [nucleotide binding]; other site 370438005752 L21 binding site [polypeptide binding]; other site 370438005753 L13 binding site [polypeptide binding]; other site 370438005754 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 370438005755 translation initiation factor IF-3; Region: infC; TIGR00168 370438005756 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 370438005757 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 370438005758 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 370438005759 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 370438005760 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 370438005761 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 370438005762 active site 370438005763 dimer interface [polypeptide binding]; other site 370438005764 motif 1; other site 370438005765 motif 2; other site 370438005766 motif 3; other site 370438005767 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 370438005768 anticodon binding site; other site 370438005769 YtxC-like family; Region: YtxC; cl08500 370438005770 PDGLE domain; Region: PDGLE; cl07986 370438005771 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 370438005772 Peptidase family M48; Region: Peptidase_M48; cl12018 370438005773 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 370438005774 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 370438005775 DNA polymerase II large subunit; Provisional; Region: PRK14714 370438005776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438005777 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 370438005778 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370438005779 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 370438005780 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 370438005781 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 370438005782 AMIN domain; Region: AMIN; pfam11741 370438005783 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 370438005784 active site 370438005785 metal binding site [ion binding]; metal-binding site 370438005786 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 370438005787 active site 370438005788 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 370438005789 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 370438005790 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 370438005791 C-terminal peptidase (prc); Region: prc; TIGR00225 370438005792 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 370438005793 protein binding site [polypeptide binding]; other site 370438005794 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 370438005795 Catalytic dyad [active] 370438005796 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438005797 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438005798 DNA polymerase I; Provisional; Region: PRK05755 370438005799 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 370438005800 active site 370438005801 metal binding site 1 [ion binding]; metal-binding site 370438005802 putative 5' ssDNA interaction site; other site 370438005803 metal binding site 3; metal-binding site 370438005804 metal binding site 2 [ion binding]; metal-binding site 370438005805 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 370438005806 putative DNA binding site [nucleotide binding]; other site 370438005807 putative metal binding site [ion binding]; other site 370438005808 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 370438005809 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 370438005810 active site 370438005811 DNA binding site [nucleotide binding] 370438005812 catalytic site [active] 370438005813 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 370438005814 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 370438005815 DNA binding site [nucleotide binding] 370438005816 catalytic residue [active] 370438005817 H2TH interface [polypeptide binding]; other site 370438005818 putative catalytic residues [active] 370438005819 turnover-facilitating residue; other site 370438005820 intercalation triad [nucleotide binding]; other site 370438005821 8OG recognition residue [nucleotide binding]; other site 370438005822 putative reading head residues; other site 370438005823 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 370438005824 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 370438005825 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 370438005826 Domain of unknown function DUF; Region: DUF204; pfam02659 370438005827 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 370438005828 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 370438005829 CoA-binding site [chemical binding]; other site 370438005830 ATP-binding [chemical binding]; other site 370438005831 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 370438005832 N-acetyl-D-glucosamine binding site [chemical binding]; other site 370438005833 catalytic residue [active] 370438005834 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 370438005835 radical SAM protein, TIGR01212 family; Region: TIGR01212 370438005836 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 370438005837 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 370438005838 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 370438005839 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 370438005840 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 370438005841 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370438005842 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 370438005843 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 370438005844 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 370438005845 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 370438005846 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 370438005847 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 370438005848 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 370438005849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005850 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 370438005851 Predicted transcriptional regulator [Transcription]; Region: COG2378 370438005852 Helix-turn-helix domains; Region: HTH; cl00088 370438005853 WYL domain; Region: WYL; cl14852 370438005854 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 370438005855 generic binding surface II; other site 370438005856 generic binding surface I; other site 370438005857 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 370438005858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438005859 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 370438005860 L-ascorbate oxidase, plant type; Region: ascorbase; TIGR03388 370438005861 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 370438005862 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 370438005863 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 370438005864 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438005865 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438005866 active site 370438005867 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 370438005868 Ligand binding site [chemical binding]; other site 370438005869 Electron transfer flavoprotein domain; Region: ETF; pfam01012 370438005870 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 370438005871 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 370438005872 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 370438005873 PAS domain S-box; Region: sensory_box; TIGR00229 370438005874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438005875 putative active site [active] 370438005876 heme pocket [chemical binding]; other site 370438005877 PAS domain S-box; Region: sensory_box; TIGR00229 370438005878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438005879 putative active site [active] 370438005880 heme pocket [chemical binding]; other site 370438005881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438005882 PAS fold; Region: PAS_4; pfam08448 370438005883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438005884 metal binding site [ion binding]; metal-binding site 370438005885 active site 370438005886 I-site; other site 370438005887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438005888 Zn2+ binding site [ion binding]; other site 370438005889 Mg2+ binding site [ion binding]; other site 370438005890 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 370438005891 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 370438005892 homodimer interface [polypeptide binding]; other site 370438005893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438005894 catalytic residue [active] 370438005895 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 370438005896 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 370438005897 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 370438005898 active site 370438005899 metal binding site [ion binding]; metal-binding site 370438005900 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438005901 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 370438005902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005903 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005904 G4 box; other site 370438005905 G5 box; other site 370438005906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 370438005907 catalytic loop [active] 370438005908 iron binding site [ion binding]; other site 370438005909 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 370438005910 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 370438005911 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 370438005912 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 370438005913 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 370438005914 dimer interface [polypeptide binding]; other site 370438005915 [2Fe-2S] cluster binding site [ion binding]; other site 370438005916 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 370438005917 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 370438005918 SLBB domain; Region: SLBB; pfam10531 370438005919 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 370438005920 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 370438005921 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 370438005922 putative dimer interface [polypeptide binding]; other site 370438005923 [2Fe-2S] cluster binding site [ion binding]; other site 370438005924 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 370438005925 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 370438005926 Helix-turn-helix domains; Region: HTH; cl00088 370438005927 DEAD-like helicases superfamily; Region: DEXDc; smart00487 370438005928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438005929 ATP binding site [chemical binding]; other site 370438005930 putative Mg++ binding site [ion binding]; other site 370438005931 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 370438005932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005933 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 370438005934 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 370438005935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005936 G1 box; other site 370438005937 GTP/Mg2+ binding site [chemical binding]; other site 370438005938 G2 box; other site 370438005939 Switch I region; other site 370438005940 G3 box; other site 370438005941 Switch II region; other site 370438005942 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 370438005943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005944 G1 box; other site 370438005945 GTP/Mg2+ binding site [chemical binding]; other site 370438005946 G2 box; other site 370438005947 Switch I region; other site 370438005948 G3 box; other site 370438005949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438005950 G3 box; other site 370438005951 Switch II region; other site 370438005952 GTP/Mg2+ binding site [chemical binding]; other site 370438005953 G4 box; other site 370438005954 G5 box; other site 370438005955 Coat F domain; Region: Coat_F; cl15836 370438005956 Transposase domain (DUF772); Region: DUF772; cl15789 370438005957 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438005958 putative CheW interface [polypeptide binding]; other site 370438005959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438005960 Transposase domain (DUF772); Region: DUF772; cl15789 370438005961 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 370438005962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438005963 Walker A motif; other site 370438005964 ATP binding site [chemical binding]; other site 370438005965 Walker B motif; other site 370438005966 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370438005967 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370438005968 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370438005969 MgtC family; Region: MgtC; pfam02308 370438005970 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 370438005971 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 370438005972 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 370438005973 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 370438005974 active site 370438005975 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 370438005976 Phosphate transporter family; Region: PHO4; cl00396 370438005977 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 370438005978 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 370438005979 trimer interface [polypeptide binding]; other site 370438005980 putative metal binding site [ion binding]; other site 370438005981 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 370438005982 BON domain; Region: BON; cl02771 370438005983 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 370438005984 GAF domain; Region: GAF; cl15785 370438005985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438005986 dimer interface [polypeptide binding]; other site 370438005987 phosphorylation site [posttranslational modification] 370438005988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438005989 ATP binding site [chemical binding]; other site 370438005990 Mg2+ binding site [ion binding]; other site 370438005991 G-X-G motif; other site 370438005992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 370438005993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438005994 active site 370438005995 phosphorylation site [posttranslational modification] 370438005996 intermolecular recognition site; other site 370438005997 dimerization interface [polypeptide binding]; other site 370438005998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 370438005999 DNA binding residues [nucleotide binding] 370438006000 dimerization interface [polypeptide binding]; other site 370438006001 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438006002 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438006003 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438006004 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438006005 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 370438006006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438006007 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 370438006008 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 370438006009 NodB motif; other site 370438006010 putative active site [active] 370438006011 putative catalytic site [active] 370438006012 putative Zn binding site [ion binding]; other site 370438006013 Family description; Region: VCBS; pfam13517 370438006014 FG-GAP repeat; Region: FG-GAP; cl15299 370438006015 Family description; Region: VCBS; pfam13517 370438006016 FG-GAP repeat; Region: FG-GAP; cl15299 370438006017 Family description; Region: VCBS; pfam13517 370438006018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006019 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 370438006020 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 370438006021 Protein of unknown function (DUF503); Region: DUF503; cl00669 370438006022 pyrophosphatase PpaX; Provisional; Region: PRK13288 370438006023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370438006024 motif II; other site 370438006025 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 370438006026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 370438006027 active site 370438006028 metal binding site [ion binding]; metal-binding site 370438006029 flagellar motor switch protein; Validated; Region: PRK08119 370438006030 Chemotaxis phosphatase CheX; Region: CheX; cl15816 370438006031 Chemotaxis phosphatase CheX; Region: CheX; cl15816 370438006032 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 370438006033 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 370438006034 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 370438006035 Response regulator receiver domain; Region: Response_reg; pfam00072 370438006036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438006037 active site 370438006038 phosphorylation site [posttranslational modification] 370438006039 intermolecular recognition site; other site 370438006040 dimerization interface [polypeptide binding]; other site 370438006041 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 370438006042 Chemotaxis phosphatase CheX; Region: CheX; cl15816 370438006043 Chemotaxis phosphatase CheX; Region: CheX; cl15816 370438006044 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 370438006045 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 370438006046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438006047 CheD chemotactic sensory transduction; Region: CheD; cl00810 370438006048 flagellar basal-body rod protein FlgG, Gram-negative bacteria; Region: flgG_G_neg; TIGR02488 370438006049 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 370438006050 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 370438006051 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 370438006052 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 370438006053 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 370438006054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438006055 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 370438006056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438006057 DNA binding residues [nucleotide binding] 370438006058 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 370438006059 Flagellar protein YcgR; Region: YcgR_2; pfam12945 370438006060 PilZ domain; Region: PilZ; cl01260 370438006061 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 370438006062 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 370438006063 P-loop; other site 370438006064 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 370438006065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006066 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 370438006067 FHIPEP family; Region: FHIPEP; pfam00771 370438006068 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 370438006069 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 370438006070 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 370438006071 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 370438006072 FliP family; Region: FliP; cl00593 370438006073 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 370438006074 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 370438006075 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 370438006076 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 370438006077 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 370438006078 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 370438006079 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 370438006080 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 370438006081 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 370438006082 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 370438006083 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 370438006084 Flagellar FliJ protein; Region: FliJ; pfam02050 370438006085 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 370438006086 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370438006087 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 370438006088 Walker A motif/ATP binding site; other site 370438006089 Walker B motif; other site 370438006090 S-layer homology domain; Region: SLH; pfam00395 370438006091 S-layer homology domain; Region: SLH; pfam00395 370438006092 Plant ATP synthase F0; Region: YMF19; cl07975 370438006093 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 370438006094 Flagellar assembly protein FliH; Region: FliH; pfam02108 370438006095 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 370438006096 MgtE intracellular N domain; Region: MgtE_N; cl15244 370438006097 FliG C-terminal domain; Region: FliG_C; pfam01706 370438006098 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 370438006099 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 370438006100 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 370438006101 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 370438006102 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 370438006103 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 370438006104 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 370438006105 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 370438006106 FlaG protein; Region: FlaG; cl00591 370438006107 FlgN protein; Region: FlgN; cl09176 370438006108 Flagellar protein FliS; Region: FliS; cl00654 370438006109 flagellar capping protein; Validated; Region: fliD; PRK07737 370438006110 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 370438006111 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 370438006112 FliW protein; Region: FliW; cl00740 370438006113 Global regulator protein family; Region: CsrA; cl00670 370438006114 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 370438006115 active site 370438006116 NTP binding site [chemical binding]; other site 370438006117 metal binding triad [ion binding]; metal-binding site 370438006118 antibiotic binding site [chemical binding]; other site 370438006119 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 370438006120 active site 370438006121 catalytic triad [active] 370438006122 dimer interface [polypeptide binding]; other site 370438006123 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 370438006124 putative active site [active] 370438006125 putative NTP binding site [chemical binding]; other site 370438006126 putative nucleic acid binding site [nucleotide binding]; other site 370438006127 flagellin; Validated; Region: PRK08026 370438006128 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 370438006129 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 370438006130 Restriction endonuclease; Region: Mrr_cat; cl00516 370438006131 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 370438006132 Protein of unknown function DUF86; Region: DUF86; cl01031 370438006133 Transposase IS200 like; Region: Y1_Tnp; cl00848 370438006134 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 370438006135 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 370438006136 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 370438006137 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 370438006138 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 370438006139 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 370438006140 FlgN protein; Region: FlgN; cl09176 370438006141 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 370438006142 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 370438006143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438006144 active site 370438006145 phosphorylation site [posttranslational modification] 370438006146 intermolecular recognition site; other site 370438006147 dimerization interface [polypeptide binding]; other site 370438006148 CheB methylesterase; Region: CheB_methylest; pfam01339 370438006149 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 370438006150 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 370438006151 putative binding surface; other site 370438006152 active site 370438006153 P2 response regulator binding domain; Region: P2; pfam07194 370438006154 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 370438006155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438006156 ATP binding site [chemical binding]; other site 370438006157 Mg2+ binding site [ion binding]; other site 370438006158 G-X-G motif; other site 370438006159 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 370438006160 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 370438006161 putative CheA interaction surface; other site 370438006162 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 370438006163 flagellar motor protein MotS; Reviewed; Region: PRK06925 370438006164 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 370438006165 ligand binding site [chemical binding]; other site 370438006166 flagellar motor protein MotA; Validated; Region: PRK08124 370438006167 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 370438006168 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 370438006169 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 370438006170 HflX GTPase family; Region: HflX; cd01878 370438006171 G1 box; other site 370438006172 GTP/Mg2+ binding site [chemical binding]; other site 370438006173 Switch I region; other site 370438006174 G2 box; other site 370438006175 G3 box; other site 370438006176 Switch II region; other site 370438006177 G4 box; other site 370438006178 G5 box; other site 370438006179 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 370438006180 4Fe-4S binding domain; Region: Fer4; cl02805 370438006181 4Fe-4S binding domain; Region: Fer4; cl02805 370438006182 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 370438006183 Clp amino terminal domain; Region: Clp_N; pfam02861 370438006184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006185 Walker A motif; other site 370438006186 ATP binding site [chemical binding]; other site 370438006187 Walker B motif; other site 370438006188 arginine finger; other site 370438006189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006190 Walker A motif; other site 370438006191 ATP binding site [chemical binding]; other site 370438006192 Walker B motif; other site 370438006193 arginine finger; other site 370438006194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370438006195 chaperone protein DnaJ; Provisional; Region: PRK14299 370438006196 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 370438006197 HSP70 interaction site [polypeptide binding]; other site 370438006198 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 370438006199 substrate binding site [polypeptide binding]; other site 370438006200 dimer interface [polypeptide binding]; other site 370438006201 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 370438006202 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 370438006203 putative dimer interface [polypeptide binding]; other site 370438006204 FOG: CBS domain [General function prediction only]; Region: COG0517 370438006205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 370438006206 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 370438006207 Coat F domain; Region: Coat_F; cl15836 370438006208 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438006209 metal binding site [ion binding]; metal-binding site 370438006210 active site 370438006211 I-site; other site 370438006212 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438006213 Zn2+ binding site [ion binding]; other site 370438006214 Mg2+ binding site [ion binding]; other site 370438006215 acetyl-CoA synthetase; Provisional; Region: PRK00174 370438006216 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 370438006217 AMP-binding enzyme; Region: AMP-binding; cl15778 370438006218 AMP-binding enzyme; Region: AMP-binding; cl15778 370438006219 NifU-like domain; Region: NifU; cl00484 370438006220 Putative zinc-finger; Region: zf-HC2; cl15806 370438006221 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 370438006222 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 370438006223 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 370438006224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438006225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438006226 DNA binding residues [nucleotide binding] 370438006227 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 370438006228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438006229 active site 370438006230 DNA binding site [nucleotide binding] 370438006231 Int/Topo IB signature motif; other site 370438006232 Transposase domain (DUF772); Region: DUF772; cl15789 370438006233 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 370438006234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006235 Walker A motif; other site 370438006236 ATP binding site [chemical binding]; other site 370438006237 Walker B motif; other site 370438006238 arginine finger; other site 370438006239 Integrase core domain; Region: rve; cl01316 370438006240 Integrase core domain; Region: rve_3; cl15866 370438006241 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 370438006242 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 370438006243 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438006244 Transposase domain (DUF772); Region: DUF772; cl15789 370438006245 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 370438006246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438006247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438006248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438006249 DNA binding residues [nucleotide binding] 370438006250 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 370438006251 dephospho-CoA kinase; Region: TIGR00152 370438006252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438006253 non-specific DNA binding site [nucleotide binding]; other site 370438006254 salt bridge; other site 370438006255 sequence-specific DNA binding site [nucleotide binding]; other site 370438006256 Thymidylate synthase complementing protein; Region: Thy1; cl03630 370438006257 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438006258 putative peptidoglycan binding site; other site 370438006259 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438006260 putative peptidoglycan binding site; other site 370438006261 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 370438006262 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 370438006263 trimer interface [polypeptide binding]; other site 370438006264 active site 370438006265 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 370438006266 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 370438006267 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 370438006268 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 370438006269 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 370438006270 putative active site [active] 370438006271 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 370438006272 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 370438006273 active site 370438006274 catalytic site [active] 370438006275 substrate binding site [chemical binding]; other site 370438006276 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 370438006277 active site 370438006278 DNA binding site [nucleotide binding] 370438006279 catalytic site [active] 370438006280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438006282 non-specific DNA binding site [nucleotide binding]; other site 370438006283 salt bridge; other site 370438006284 sequence-specific DNA binding site [nucleotide binding]; other site 370438006285 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 370438006286 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 370438006287 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 370438006288 active site 370438006289 metal binding site [ion binding]; metal-binding site 370438006290 interdomain interaction site; other site 370438006291 AAA domain; Region: AAA_25; pfam13481 370438006292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006293 Walker A motif; other site 370438006294 ATP binding site [chemical binding]; other site 370438006295 Walker B motif; other site 370438006296 hypothetical protein; Validated; Region: PRK08116 370438006297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006298 Helix-turn-helix domains; Region: HTH; cl00088 370438006299 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 370438006300 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 370438006301 amidase catalytic site [active] 370438006302 Zn binding residues [ion binding]; other site 370438006303 substrate binding site [chemical binding]; other site 370438006304 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438006305 putative peptidoglycan binding site; other site 370438006306 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 370438006307 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 370438006308 amidase catalytic site [active] 370438006309 Zn binding residues [ion binding]; other site 370438006310 substrate binding site [chemical binding]; other site 370438006311 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 370438006312 Phage-related protein [Function unknown]; Region: COG4722; cl15832 370438006313 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 370438006314 Phage tail protein; Region: Sipho_tail; pfam05709 370438006315 Mu-like prophage protein [General function prediction only]; Region: COG3941 370438006316 tape measure domain; Region: tape_meas_nterm; TIGR02675 370438006317 Phage-related protein [Function unknown]; Region: COG5412 370438006318 membrane protein P6; Region: PHA01399 370438006319 Phage-related protein [Function unknown]; Region: COG5412 370438006320 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774 370438006321 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 370438006322 Phage major tail protein 2; Region: Phage_tail_2; cl11463 370438006323 Minor capsid protein; Region: Minor_capsid_1; pfam10665 370438006324 DNA polymerase II large subunit; Provisional; Region: PRK14715 370438006325 Transposase domain (DUF772); Region: DUF772; cl15789 370438006326 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438006327 Transposase domain (DUF772); Region: DUF772; cl15789 370438006328 major capsid protein; Region: PHA00665 370438006329 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 370438006330 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 370438006331 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 370438006332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 370438006333 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 370438006334 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 370438006335 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 370438006336 putative active site pocket [active] 370438006337 dimerization interface [polypeptide binding]; other site 370438006338 putative catalytic residue [active] 370438006339 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 370438006340 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 370438006341 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006342 Walker A/P-loop; other site 370438006343 ATP binding site [chemical binding]; other site 370438006344 Q-loop/lid; other site 370438006345 ABC transporter signature motif; other site 370438006346 Walker B; other site 370438006347 D-loop; other site 370438006348 H-loop/switch region; other site 370438006349 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370438006350 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 370438006351 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 370438006352 P-loop; other site 370438006353 Magnesium ion binding site [ion binding]; other site 370438006354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 370438006355 Magnesium ion binding site [ion binding]; other site 370438006356 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438006357 Transposase domain (DUF772); Region: DUF772; cl15789 370438006358 Transposase domain (DUF772); Region: DUF772; cl15789 370438006359 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438006360 Helix-turn-helix domains; Region: HTH; cl00088 370438006361 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438006362 Amino acid permease; Region: AA_permease_2; pfam13520 370438006363 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 370438006364 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 370438006365 putative ADP-ribose binding site [chemical binding]; other site 370438006366 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 370438006367 active site 370438006368 catalytic triad [active] 370438006369 oxyanion hole [active] 370438006370 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 370438006371 pyruvate kinase; Provisional; Region: PRK06354 370438006372 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 370438006373 domain interfaces; other site 370438006374 active site 370438006375 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 370438006376 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 370438006377 active site 370438006378 ADP/pyrophosphate binding site [chemical binding]; other site 370438006379 dimerization interface [polypeptide binding]; other site 370438006380 allosteric effector site; other site 370438006381 fructose-1,6-bisphosphate binding site; other site 370438006382 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370438006383 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 370438006384 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 370438006385 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370438006386 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 370438006387 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 370438006388 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 370438006389 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 370438006390 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 370438006391 generic binding surface II; other site 370438006392 generic binding surface I; other site 370438006393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 370438006394 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 370438006395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438006396 dimer interface [polypeptide binding]; other site 370438006397 putative CheW interface [polypeptide binding]; other site 370438006398 Uncharacterized conserved protein [Function unknown]; Region: COG3287 370438006399 FIST N domain; Region: FIST; cl10701 370438006400 FIST C domain; Region: FIST_C; pfam10442 370438006401 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 370438006402 putative deacylase active site [active] 370438006403 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 370438006404 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 370438006405 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 370438006406 minor groove reading motif; other site 370438006407 helix-hairpin-helix signature motif; other site 370438006408 substrate binding pocket [chemical binding]; other site 370438006409 active site 370438006410 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 370438006411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 370438006412 Uncharacterized conserved protein [Function unknown]; Region: COG1543 370438006413 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 370438006414 glycolate transporter; Provisional; Region: PRK09695 370438006415 L-lactate permease; Region: Lactate_perm; cl00701 370438006416 FAD binding domain; Region: FAD_binding_4; pfam01565 370438006417 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 370438006418 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438006419 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 370438006420 Cysteine-rich domain; Region: CCG; pfam02754 370438006421 Cysteine-rich domain; Region: CCG; pfam02754 370438006422 Transcriptional regulators [Transcription]; Region: FadR; COG2186 370438006423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370438006424 DNA-binding site [nucleotide binding]; DNA binding site 370438006425 FCD domain; Region: FCD; cl11656 370438006426 Transcriptional regulators [Transcription]; Region: FadR; COG2186 370438006427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370438006428 DNA-binding site [nucleotide binding]; DNA binding site 370438006429 FCD domain; Region: FCD; cl11656 370438006430 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 370438006431 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 370438006432 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438006433 Cysteine-rich domain; Region: CCG; pfam02754 370438006434 Cysteine-rich domain; Region: CCG; pfam02754 370438006435 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 370438006436 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 370438006437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006438 DRTGG domain; Region: DRTGG; cl12147 370438006439 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 370438006440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438006441 CoA-ligase; Region: Ligase_CoA; cl02894 370438006442 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438006443 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 370438006444 putative trimer interface [polypeptide binding]; other site 370438006445 putative CoA binding site [chemical binding]; other site 370438006446 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 370438006447 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 370438006448 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 370438006449 catalytic residues [active] 370438006450 catalytic nucleophile [active] 370438006451 Recombinase; Region: Recombinase; pfam07508 370438006452 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370438006453 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 370438006454 Abi-like protein; Region: Abi_2; cl01988 370438006455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438006456 Zn2+ binding site [ion binding]; other site 370438006457 Mg2+ binding site [ion binding]; other site 370438006458 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438006459 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 370438006460 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 370438006461 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438006462 Low molecular weight phosphatase family; Region: LMWPc; cl00105 370438006463 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4871 370438006464 Putative Fe-S cluster; Region: FeS; pfam04060 370438006465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 370438006466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 370438006467 sensory histidine kinase AtoS; Provisional; Region: PRK11360 370438006468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438006469 putative active site [active] 370438006470 heme pocket [chemical binding]; other site 370438006471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438006472 phosphorylation site [posttranslational modification] 370438006473 dimer interface [polypeptide binding]; other site 370438006474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438006475 ATP binding site [chemical binding]; other site 370438006476 Mg2+ binding site [ion binding]; other site 370438006477 G-X-G motif; other site 370438006478 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 370438006479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438006480 active site 370438006481 phosphorylation site [posttranslational modification] 370438006482 intermolecular recognition site; other site 370438006483 dimerization interface [polypeptide binding]; other site 370438006484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006485 Walker A motif; other site 370438006486 ATP binding site [chemical binding]; other site 370438006487 Walker B motif; other site 370438006488 arginine finger; other site 370438006489 Helix-turn-helix domains; Region: HTH; cl00088 370438006490 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 370438006491 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 370438006492 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 370438006493 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 370438006494 Walker A/P-loop; other site 370438006495 ATP binding site [chemical binding]; other site 370438006496 Q-loop/lid; other site 370438006497 ABC transporter signature motif; other site 370438006498 Walker B; other site 370438006499 D-loop; other site 370438006500 H-loop/switch region; other site 370438006501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438006502 dimer interface [polypeptide binding]; other site 370438006503 conserved gate region; other site 370438006504 putative PBP binding loops; other site 370438006505 ABC-ATPase subunit interface; other site 370438006506 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 370438006507 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 370438006508 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 370438006509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438006510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438006511 DNA binding residues [nucleotide binding] 370438006512 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 370438006513 xanthine permease; Region: pbuX; TIGR03173 370438006514 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 370438006515 anti sigma factor interaction site; other site 370438006516 regulatory phosphorylation site [posttranslational modification]; other site 370438006517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 370438006518 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370438006519 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 370438006520 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 370438006521 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 370438006522 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 370438006523 anti sigma factor interaction site; other site 370438006524 regulatory phosphorylation site [posttranslational modification]; other site 370438006525 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 370438006526 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 370438006527 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 370438006528 Walker A/P-loop; other site 370438006529 ATP binding site [chemical binding]; other site 370438006530 Q-loop/lid; other site 370438006531 ABC transporter signature motif; other site 370438006532 Walker B; other site 370438006533 D-loop; other site 370438006534 H-loop/switch region; other site 370438006535 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006536 ABC transporter signature motif; other site 370438006537 Walker B; other site 370438006538 D-loop; other site 370438006539 H-loop/switch region; other site 370438006540 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 370438006541 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 370438006542 putative ligand binding site [chemical binding]; other site 370438006543 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 370438006544 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 370438006545 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 370438006546 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 370438006547 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 370438006548 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 370438006549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438006550 FeS/SAM binding site; other site 370438006551 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438006552 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006553 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006554 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438006556 DNA binding residues [nucleotide binding] 370438006557 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 370438006558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438006559 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 370438006560 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 370438006561 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 370438006562 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 370438006563 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370438006564 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 370438006565 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438006566 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438006567 active site 370438006568 DNA binding site [nucleotide binding] 370438006569 Int/Topo IB signature motif; other site 370438006570 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 370438006571 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 370438006572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438006573 active site 370438006574 DNA binding site [nucleotide binding] 370438006575 Int/Topo IB signature motif; other site 370438006576 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 370438006577 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 370438006578 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 370438006579 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370438006580 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006581 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006582 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006583 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 370438006584 putative active site [active] 370438006585 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 370438006586 putative active site [active] 370438006587 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 370438006588 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 370438006589 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438006590 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006591 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006592 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006593 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006594 Peptidase family M23; Region: Peptidase_M23; pfam01551 370438006595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438006596 D-galactonate transporter; Region: 2A0114; TIGR00893 370438006597 putative substrate translocation pore; other site 370438006598 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 370438006599 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 370438006600 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370438006601 guanine deaminase; Region: guan_deamin; TIGR02967 370438006602 active site 370438006603 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 370438006604 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006605 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006606 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 370438006607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006608 Transposase [DNA replication, recombination, and repair]; Region: COG5421 370438006609 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006610 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 370438006611 YcaO-like family; Region: YcaO; pfam02624 370438006612 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 370438006613 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 370438006614 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 370438006615 Walker A/P-loop; other site 370438006616 ATP binding site [chemical binding]; other site 370438006617 Q-loop/lid; other site 370438006618 ABC transporter signature motif; other site 370438006619 Walker B; other site 370438006620 D-loop; other site 370438006621 H-loop/switch region; other site 370438006622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370438006623 substrate binding pocket [chemical binding]; other site 370438006624 membrane-bound complex binding site; other site 370438006625 hinge residues; other site 370438006626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370438006627 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370438006628 substrate binding pocket [chemical binding]; other site 370438006629 membrane-bound complex binding site; other site 370438006630 hinge residues; other site 370438006631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370438006632 substrate binding pocket [chemical binding]; other site 370438006633 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 370438006634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370438006635 dimer interface [polypeptide binding]; other site 370438006636 conserved gate region; other site 370438006637 putative PBP binding loops; other site 370438006638 ABC-ATPase subunit interface; other site 370438006639 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 370438006640 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 370438006641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370438006642 active site 370438006643 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006644 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 370438006645 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438006646 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006647 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438006648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438006649 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 370438006650 FeS/SAM binding site; other site 370438006651 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438006652 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006654 Walker A/P-loop; other site 370438006655 ATP binding site [chemical binding]; other site 370438006656 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 370438006657 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 370438006658 Walker A/P-loop; other site 370438006659 ATP binding site [chemical binding]; other site 370438006660 Q-loop/lid; other site 370438006661 ABC transporter signature motif; other site 370438006662 Walker B; other site 370438006663 D-loop; other site 370438006664 H-loop/switch region; other site 370438006665 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 370438006666 TM-ABC transporter signature motif; other site 370438006667 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 370438006668 TM-ABC transporter signature motif; other site 370438006669 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 370438006670 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 370438006671 putative ligand binding site [chemical binding]; other site 370438006672 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006673 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006674 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006675 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006676 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006677 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438006678 MULE transposase domain; Region: MULE; pfam10551 370438006679 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 370438006680 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370438006681 guanine deaminase; Region: guan_deamin; TIGR02967 370438006682 active site 370438006683 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438006684 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 370438006685 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 370438006686 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 370438006687 S-layer homology domain; Region: SLH; pfam00395 370438006688 S-layer homology domain; Region: SLH; pfam00395 370438006689 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438006690 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 370438006691 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 370438006692 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370438006693 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 370438006694 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 370438006695 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 370438006696 active site 370438006697 metal binding site [ion binding]; metal-binding site 370438006698 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 370438006699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438006700 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006701 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 370438006702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438006703 FeS/SAM binding site; other site 370438006704 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438006705 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 370438006706 nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064 370438006707 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438006708 nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064 370438006709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 370438006710 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438006711 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370438006712 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 370438006713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438006714 S-adenosylmethionine binding site [chemical binding]; other site 370438006715 phosphoenolpyruvate synthase; Validated; Region: PRK06241 370438006716 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 370438006717 phosphoenolpyruvate synthase; Validated; Region: PRK06241 370438006718 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 370438006719 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 370438006720 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370438006721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006722 Walker A/P-loop; other site 370438006723 ATP binding site [chemical binding]; other site 370438006724 Q-loop/lid; other site 370438006725 ABC transporter signature motif; other site 370438006726 Walker B; other site 370438006727 D-loop; other site 370438006728 H-loop/switch region; other site 370438006729 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 370438006730 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39D; cd02420 370438006731 putative active site [active] 370438006732 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370438006733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006734 Walker A/P-loop; other site 370438006735 ATP binding site [chemical binding]; other site 370438006736 Q-loop/lid; other site 370438006737 ABC transporter signature motif; other site 370438006738 Walker B; other site 370438006739 D-loop; other site 370438006740 H-loop/switch region; other site 370438006741 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 370438006742 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438006743 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438006744 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 370438006745 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 370438006746 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 370438006747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438006748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438006749 DNA binding residues [nucleotide binding] 370438006750 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 370438006751 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 370438006752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438006753 dimer interface [polypeptide binding]; other site 370438006754 phosphorylation site [posttranslational modification] 370438006755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438006756 ATP binding site [chemical binding]; other site 370438006757 Mg2+ binding site [ion binding]; other site 370438006758 G-X-G motif; other site 370438006759 Response regulator receiver domain; Region: Response_reg; pfam00072 370438006760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438006761 active site 370438006762 phosphorylation site [posttranslational modification] 370438006763 intermolecular recognition site; other site 370438006764 dimerization interface [polypeptide binding]; other site 370438006765 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 370438006766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438006767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438006768 active site 370438006769 phosphorylation site [posttranslational modification] 370438006770 intermolecular recognition site; other site 370438006771 dimerization interface [polypeptide binding]; other site 370438006772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438006773 DNA binding site [nucleotide binding] 370438006774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370438006775 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 370438006776 Coenzyme A binding pocket [chemical binding]; other site 370438006777 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 370438006778 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438006779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 370438006780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 370438006781 DNA-binding interface [nucleotide binding]; DNA binding site 370438006782 Integrase core domain; Region: rve; cl01316 370438006783 Integrase core domain; Region: rve_3; cl15866 370438006784 transposase; Provisional; Region: PRK06526 370438006785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006786 Walker A motif; other site 370438006787 ATP binding site [chemical binding]; other site 370438006788 Walker B motif; other site 370438006789 arginine finger; other site 370438006790 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438006791 MULE transposase domain; Region: MULE; pfam10551 370438006792 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 370438006793 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 370438006794 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 370438006795 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370438006796 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 370438006797 Integrase core domain; Region: rve; cl01316 370438006798 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 370438006799 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 370438006800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438006801 Protein of unknown function DUF45; Region: DUF45; cl00636 370438006802 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 370438006803 Protein of unknown function (DUF499); Region: DUF499; pfam04465 370438006804 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 370438006805 Helix-turn-helix domains; Region: HTH; cl00088 370438006806 Winged helix-turn helix; Region: HTH_29; pfam13551 370438006807 Helix-turn-helix domains; Region: HTH; cl00088 370438006808 Integrase core domain; Region: rve; cl01316 370438006809 Integrase core domain; Region: rve_3; cl15866 370438006810 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 370438006811 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438006812 putative peptidoglycan binding site; other site 370438006813 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438006814 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 370438006815 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 370438006816 catalytic Zn binding site [ion binding]; other site 370438006817 structural Zn binding site [ion binding]; other site 370438006818 tetramer interface [polypeptide binding]; other site 370438006819 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438006820 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438006821 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438006822 Transposase domain (DUF772); Region: DUF772; cl15789 370438006823 Transposase domain (DUF772); Region: DUF772; cl15789 370438006824 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438006825 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 370438006826 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 370438006827 putative active site [active] 370438006828 putative NTP binding site [chemical binding]; other site 370438006829 putative nucleic acid binding site [nucleotide binding]; other site 370438006830 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 370438006831 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438006832 MULE transposase domain; Region: MULE; pfam10551 370438006833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438006834 Integrase core domain; Region: rve; cl01316 370438006835 DDE domain; Region: DDE_Tnp_IS240; pfam13610 370438006836 Integrase core domain; Region: rve_3; cl15866 370438006837 Helix-turn-helix domains; Region: HTH; cl00088 370438006838 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 370438006839 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 370438006840 putative active site [active] 370438006841 putative NTP binding site [chemical binding]; other site 370438006842 putative nucleic acid binding site [nucleotide binding]; other site 370438006843 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 370438006844 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5...; Region: Glm_B12_BD; cd02072 370438006845 B12 binding site [chemical binding]; other site 370438006846 heterodimer interface [polypeptide binding]; other site 370438006847 cobalt ligand [ion binding]; other site 370438006848 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 370438006849 substrate binding site [chemical binding]; other site 370438006850 B12 cofactor binding site [chemical binding]; other site 370438006851 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 370438006852 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 370438006853 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 370438006854 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 370438006855 4Fe-4S binding domain; Region: Fer4; cl02805 370438006856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438006857 FeS/SAM binding site; other site 370438006858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 370438006859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438006860 putative substrate translocation pore; other site 370438006861 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 370438006862 putative FMN binding site [chemical binding]; other site 370438006863 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 370438006864 Integrase core domain; Region: rve; cl01316 370438006865 Integrase core domain; Region: rve_3; cl15866 370438006866 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 370438006867 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 370438006868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006869 Walker A motif; other site 370438006870 ATP binding site [chemical binding]; other site 370438006871 Walker B motif; other site 370438006872 arginine finger; other site 370438006873 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438006874 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370438006875 oxidoreductase; Provisional; Region: PRK10015 370438006876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438006877 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 370438006878 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 370438006879 Ligand binding site [chemical binding]; other site 370438006880 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 370438006881 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 370438006882 Ligand binding site [chemical binding]; other site 370438006883 Electron transfer flavoprotein domain; Region: ETF; pfam01012 370438006884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438006885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438006886 active site 370438006887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 370438006888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 370438006889 active site 370438006890 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 370438006891 MutL protein; Region: MutL; pfam13941 370438006892 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 370438006893 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 370438006894 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370438006895 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 370438006896 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 370438006897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006898 Walker A motif; other site 370438006899 ATP binding site [chemical binding]; other site 370438006900 Walker B motif; other site 370438006901 arginine finger; other site 370438006902 Helix-turn-helix domains; Region: HTH; cl00088 370438006903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438006904 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 370438006905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438006906 ATP binding site [chemical binding]; other site 370438006907 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 370438006908 putative Mg++ binding site [ion binding]; other site 370438006909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438006910 nucleotide binding region [chemical binding]; other site 370438006911 ATP-binding site [chemical binding]; other site 370438006912 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 370438006913 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 370438006914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438006915 non-specific DNA binding site [nucleotide binding]; other site 370438006916 salt bridge; other site 370438006917 sequence-specific DNA binding site [nucleotide binding]; other site 370438006918 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370438006919 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 370438006920 catalytic residues [active] 370438006921 catalytic nucleophile [active] 370438006922 Presynaptic Site I dimer interface [polypeptide binding]; other site 370438006923 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 370438006924 Synaptic Flat tetramer interface [polypeptide binding]; other site 370438006925 Synaptic Site I dimer interface [polypeptide binding]; other site 370438006926 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 370438006927 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370438006928 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 370438006929 MULE transposase domain; Region: MULE; pfam10551 370438006930 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438006931 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438006932 active site 370438006933 DNA binding site [nucleotide binding] 370438006934 Int/Topo IB signature motif; other site 370438006935 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 370438006936 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438006937 active site 370438006938 DNA binding site [nucleotide binding] 370438006939 Int/Topo IB signature motif; other site 370438006940 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 370438006941 RNA/DNA hybrid binding site [nucleotide binding]; other site 370438006942 active site 370438006943 Fic family protein [Function unknown]; Region: COG3177 370438006944 Fic/DOC family; Region: Fic; cl00960 370438006945 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 370438006946 Zn binding site [ion binding]; other site 370438006947 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 370438006948 MPN+ (JAMM) motif; other site 370438006949 Zinc-binding site [ion binding]; other site 370438006950 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 370438006951 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 370438006952 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 370438006953 metal binding site [ion binding]; metal-binding site 370438006954 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 370438006955 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 370438006956 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 370438006957 putative active site [active] 370438006958 putative NTP binding site [chemical binding]; other site 370438006959 putative nucleic acid binding site [nucleotide binding]; other site 370438006960 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 370438006961 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 370438006962 putative active site [active] 370438006963 putative NTP binding site [chemical binding]; other site 370438006964 putative nucleic acid binding site [nucleotide binding]; other site 370438006965 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 370438006966 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 370438006967 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 370438006968 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370438006969 RNA binding site [nucleotide binding]; other site 370438006970 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370438006971 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370438006972 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438006973 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 370438006974 stage V sporulation protein K; Region: spore_V_K; TIGR02881 370438006975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438006976 Walker A motif; other site 370438006977 ATP binding site [chemical binding]; other site 370438006978 Walker B motif; other site 370438006979 arginine finger; other site 370438006980 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 370438006981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438006982 Walker A motif; other site 370438006983 ATP binding site [chemical binding]; other site 370438006984 Walker B motif; other site 370438006985 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 370438006986 IHF dimer interface [polypeptide binding]; other site 370438006987 IHF - DNA interface [nucleotide binding]; other site 370438006988 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438006989 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438006990 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 370438006991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438006992 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438006993 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 370438006994 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 370438006995 IHF - DNA interface [nucleotide binding]; other site 370438006996 IHF dimer interface [polypeptide binding]; other site 370438006997 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 370438006998 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 370438006999 polymerase nucleotide-binding site; other site 370438007000 DNA-binding residues [nucleotide binding]; DNA binding site 370438007001 nucleotide binding site [chemical binding]; other site 370438007002 primase nucleotide-binding site [nucleotide binding]; other site 370438007003 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 370438007004 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 370438007005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007006 Walker A motif; other site 370438007007 ATP binding site [chemical binding]; other site 370438007008 Walker B motif; other site 370438007009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 370438007010 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 370438007011 Transposase IS200 like; Region: Y1_Tnp; cl00848 370438007012 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438007013 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 370438007014 active site 370438007015 Substrate binding site; other site 370438007016 Mg++ binding site; other site 370438007017 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438007018 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370438007019 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 370438007020 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 370438007021 isocitrate dehydrogenase; Validated; Region: PRK07362 370438007022 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 370438007023 substrate binding site [chemical binding]; other site 370438007024 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 370438007025 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 370438007026 substrate binding site [chemical binding]; other site 370438007027 ligand binding site [chemical binding]; other site 370438007028 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 370438007029 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 370438007030 active site 370438007031 catalytic residues [active] 370438007032 metal binding site [ion binding]; metal-binding site 370438007033 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 370438007034 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 370438007035 GatB domain; Region: GatB_Yqey; cl11497 370438007036 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 370438007037 Amidase; Region: Amidase; cl11426 370438007038 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 370438007039 FOG: CBS domain [General function prediction only]; Region: COG0517 370438007040 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 370438007041 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 370438007042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438007043 putative substrate translocation pore; other site 370438007044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438007045 Transposase [DNA replication, recombination, and repair]; Region: COG5421 370438007046 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 370438007047 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 370438007048 nucleotide binding pocket [chemical binding]; other site 370438007049 K-X-D-G motif; other site 370438007050 catalytic site [active] 370438007051 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 370438007052 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 370438007053 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 370438007054 Dimer interface [polypeptide binding]; other site 370438007055 BRCT sequence motif; other site 370438007056 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 370438007057 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 370438007058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007059 Family description; Region: UvrD_C_2; cl15862 370438007060 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 370438007061 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 370438007062 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 370438007063 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 370438007064 substrate binding site [chemical binding]; other site 370438007065 glutamase interaction surface [polypeptide binding]; other site 370438007066 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 370438007067 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 370438007068 catalytic residues [active] 370438007069 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 370438007070 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 370438007071 putative active site [active] 370438007072 oxyanion strand; other site 370438007073 catalytic triad [active] 370438007074 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 370438007075 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 370438007076 putative active site pocket [active] 370438007077 4-fold oligomerization interface [polypeptide binding]; other site 370438007078 metal binding residues [ion binding]; metal-binding site 370438007079 3-fold/trimer interface [polypeptide binding]; other site 370438007080 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 370438007081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438007082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438007083 homodimer interface [polypeptide binding]; other site 370438007084 catalytic residue [active] 370438007085 histidinol dehydrogenase; Region: hisD; TIGR00069 370438007086 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 370438007087 NAD binding site [chemical binding]; other site 370438007088 dimerization interface [polypeptide binding]; other site 370438007089 product binding site; other site 370438007090 substrate binding site [chemical binding]; other site 370438007091 zinc binding site [ion binding]; other site 370438007092 catalytic residues [active] 370438007093 Helix-turn-helix domains; Region: HTH; cl00088 370438007094 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 370438007095 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 370438007096 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370438007097 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 370438007098 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 370438007099 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 370438007100 purine monophosphate binding site [chemical binding]; other site 370438007101 dimer interface [polypeptide binding]; other site 370438007102 putative catalytic residues [active] 370438007103 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 370438007104 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 370438007105 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 370438007106 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 370438007107 active site 370438007108 substrate binding site [chemical binding]; other site 370438007109 cosubstrate binding site; other site 370438007110 catalytic site [active] 370438007111 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 370438007112 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 370438007113 dimerization interface [polypeptide binding]; other site 370438007114 putative ATP binding site [chemical binding]; other site 370438007115 amidophosphoribosyltransferase; Provisional; Region: PRK05793 370438007116 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 370438007117 active site 370438007118 tetramer interface [polypeptide binding]; other site 370438007119 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438007120 active site 370438007121 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 370438007122 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 370438007123 ATP binding site [chemical binding]; other site 370438007124 active site 370438007125 substrate binding site [chemical binding]; other site 370438007126 adenylosuccinate lyase; Provisional; Region: PRK07492 370438007127 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 370438007128 tetramer interface [polypeptide binding]; other site 370438007129 active site 370438007130 AIR carboxylase; Region: AIRC; cl00310 370438007131 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 370438007132 putative active site [active] 370438007133 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 370438007134 GMP synthase; Reviewed; Region: guaA; PRK00074 370438007135 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 370438007136 AMP/PPi binding site [chemical binding]; other site 370438007137 candidate oxyanion hole; other site 370438007138 catalytic triad [active] 370438007139 potential glutamine specificity residues [chemical binding]; other site 370438007140 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 370438007141 ATP Binding subdomain [chemical binding]; other site 370438007142 Ligand Binding sites [chemical binding]; other site 370438007143 Dimerization subdomain; other site 370438007144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438007145 active site 370438007146 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 370438007147 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 370438007148 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 370438007149 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 370438007150 putative active site [active] 370438007151 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 370438007152 putative active site [active] 370438007153 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 370438007154 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438007155 Zn2+ binding site [ion binding]; other site 370438007156 Mg2+ binding site [ion binding]; other site 370438007157 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 370438007158 Bacterial sugar transferase; Region: Bac_transf; cl00939 370438007159 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 370438007160 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 370438007161 putative ADP-binding pocket [chemical binding]; other site 370438007162 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 370438007163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438007164 Zn2+ binding site [ion binding]; other site 370438007165 Mg2+ binding site [ion binding]; other site 370438007166 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438007167 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438007168 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438007169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438007170 FeS/SAM binding site; other site 370438007171 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438007172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007173 Transposase domain (DUF772); Region: DUF772; cl15789 370438007174 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 370438007175 Transposase domain (DUF772); Region: DUF772; cl15789 370438007176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370438007177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438007178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370438007179 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 370438007180 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 370438007181 inhibitor-cofactor binding pocket; inhibition site 370438007182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438007183 catalytic residue [active] 370438007184 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 370438007185 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 370438007186 Walker A/P-loop; other site 370438007187 ATP binding site [chemical binding]; other site 370438007188 Q-loop/lid; other site 370438007189 ABC transporter signature motif; other site 370438007190 Walker B; other site 370438007191 D-loop; other site 370438007192 H-loop/switch region; other site 370438007193 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438007194 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 370438007195 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 370438007196 NADP binding site [chemical binding]; other site 370438007197 active site 370438007198 putative substrate binding site [chemical binding]; other site 370438007199 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 370438007200 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 370438007201 NAD binding site [chemical binding]; other site 370438007202 substrate binding site [chemical binding]; other site 370438007203 homodimer interface [polypeptide binding]; other site 370438007204 active site 370438007205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370438007206 active site 370438007207 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 370438007208 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 370438007209 Probable Catalytic site; other site 370438007210 metal-binding site 370438007211 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 370438007212 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 370438007213 Probable Catalytic site; other site 370438007214 metal-binding site 370438007215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 370438007216 putative homodimer interface [polypeptide binding]; other site 370438007217 O-Antigen ligase; Region: Wzy_C; cl04850 370438007218 O-Antigen ligase; Region: Wzy_C; cl04850 370438007219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 370438007220 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 370438007221 TPR motif; other site 370438007222 binding surface 370438007223 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 370438007224 active site 370438007225 NTP binding site [chemical binding]; other site 370438007226 metal binding triad [ion binding]; metal-binding site 370438007227 antibiotic binding site [chemical binding]; other site 370438007228 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438007229 CHASE3 domain; Region: CHASE3; cl05000 370438007230 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 370438007231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438007232 dimerization interface [polypeptide binding]; other site 370438007233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438007234 dimer interface [polypeptide binding]; other site 370438007235 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 370438007236 putative CheW interface [polypeptide binding]; other site 370438007237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 370438007238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370438007239 non-specific DNA binding site [nucleotide binding]; other site 370438007240 salt bridge; other site 370438007241 sequence-specific DNA binding site [nucleotide binding]; other site 370438007242 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 370438007243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438007244 putative substrate translocation pore; other site 370438007245 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 370438007246 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438007247 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 370438007248 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 370438007249 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 370438007250 putative catalytic cysteine [active] 370438007251 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438007252 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 370438007253 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 370438007254 dimer interface [polypeptide binding]; other site 370438007255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438007256 catalytic residue [active] 370438007257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438007258 dimer interface [polypeptide binding]; other site 370438007259 putative CheW interface [polypeptide binding]; other site 370438007260 Radical SAM superfamily; Region: Radical_SAM; pfam04055 370438007261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438007262 FeS/SAM binding site; other site 370438007263 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438007264 putative peptidoglycan binding site; other site 370438007265 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 370438007266 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438007267 putative peptidoglycan binding site; other site 370438007268 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 370438007269 Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389 370438007270 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 370438007271 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 370438007272 RNA/DNA hybrid binding site [nucleotide binding]; other site 370438007273 active site 370438007274 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 370438007275 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 370438007276 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 370438007277 DNA binding site [nucleotide binding] 370438007278 active site 370438007279 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438007280 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438007281 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438007282 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 370438007283 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 370438007284 ring oligomerisation interface [polypeptide binding]; other site 370438007285 ATP/Mg binding site [chemical binding]; other site 370438007286 stacking interactions; other site 370438007287 hinge regions; other site 370438007288 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370438007289 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 370438007290 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 370438007291 oligomerisation interface [polypeptide binding]; other site 370438007292 mobile loop; other site 370438007293 roof hairpin; other site 370438007294 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 370438007295 MPT binding site; other site 370438007296 trimer interface [polypeptide binding]; other site 370438007297 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 370438007298 trimer interface [polypeptide binding]; other site 370438007299 dimer interface [polypeptide binding]; other site 370438007300 putative active site [active] 370438007301 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 370438007302 S-layer homology domain; Region: SLH; pfam00395 370438007303 S-layer homology domain; Region: SLH; pfam00395 370438007304 cyclase homology domain; Region: CHD; cd07302 370438007305 dimer interface [polypeptide binding]; other site 370438007306 CHASE2 domain; Region: CHASE2; cl01732 370438007307 cyclase homology domain; Region: CHD; cd07302 370438007308 metal binding site [ion binding]; metal-binding site 370438007309 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 370438007310 GAF domain; Region: GAF_2; pfam13185 370438007311 GAF domain; Region: GAF; cl15785 370438007312 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 370438007313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438007314 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 370438007315 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 370438007316 dimer interface [polypeptide binding]; other site 370438007317 putative functional site; other site 370438007318 putative MPT binding site; other site 370438007319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370438007320 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 370438007321 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 370438007322 dimer interface [polypeptide binding]; other site 370438007323 putative functional site; other site 370438007324 putative MPT binding site; other site 370438007325 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 370438007326 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 370438007327 ATP binding site [chemical binding]; other site 370438007328 substrate interface [chemical binding]; other site 370438007329 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 370438007330 Walker A motif; other site 370438007331 MOSC domain; Region: MOSC; pfam03473 370438007332 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 370438007333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438007334 FeS/SAM binding site; other site 370438007335 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 370438007336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 370438007337 Helix-turn-helix domains; Region: HTH; cl00088 370438007338 Ubiquitin-like proteins; Region: UBQ; cl00155 370438007339 charged pocket; other site 370438007340 hydrophobic patch; other site 370438007341 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 370438007342 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 370438007343 Ligand Binding Site [chemical binding]; other site 370438007344 Protein of unknown function DUF111; Region: DUF111; cl03398 370438007345 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 370438007346 AIR carboxylase; Region: AIRC; cl00310 370438007347 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 370438007348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007349 NAD(P) binding site [chemical binding]; other site 370438007350 active site 370438007351 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 370438007352 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 370438007353 Walker A motif; other site 370438007354 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 370438007355 4Fe-4S binding domain; Region: Fer4; cl02805 370438007356 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 370438007357 Uncharacterized conserved protein [Function unknown]; Region: COG2006 370438007358 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438007359 DDE superfamily endonuclease; Region: DDE_5; cl02413 370438007360 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438007361 Response regulator receiver domain; Region: Response_reg; pfam00072 370438007362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438007363 active site 370438007364 phosphorylation site [posttranslational modification] 370438007365 intermolecular recognition site; other site 370438007366 dimerization interface [polypeptide binding]; other site 370438007367 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370438007368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438007369 Walker A motif; other site 370438007370 ATP binding site [chemical binding]; other site 370438007371 Walker B motif; other site 370438007372 arginine finger; other site 370438007373 Helix-turn-helix domains; Region: HTH; cl00088 370438007374 GAF domain; Region: GAF_2; pfam13185 370438007375 GAF domain; Region: GAF; cl15785 370438007376 sensory histidine kinase AtoS; Provisional; Region: PRK11360 370438007377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438007378 dimer interface [polypeptide binding]; other site 370438007379 phosphorylation site [posttranslational modification] 370438007380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438007381 ATP binding site [chemical binding]; other site 370438007382 Mg2+ binding site [ion binding]; other site 370438007383 G-X-G motif; other site 370438007384 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 370438007385 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438007386 putative active site [active] 370438007387 metal binding site [ion binding]; metal-binding site 370438007388 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 370438007389 putative active site [active] 370438007390 putative metal binding site [ion binding]; other site 370438007391 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 370438007392 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438007393 molybdopterin cofactor binding site; other site 370438007394 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 370438007395 molybdopterin cofactor binding site; other site 370438007396 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 370438007397 catalytic loop [active] 370438007398 iron binding site [ion binding]; other site 370438007399 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 370438007400 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438007401 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 370438007402 4Fe-4S binding domain; Region: Fer4; cl02805 370438007403 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 370438007404 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438007405 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 370438007406 catalytic loop [active] 370438007407 iron binding site [ion binding]; other site 370438007408 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 370438007409 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 370438007410 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 370438007411 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 370438007412 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438007413 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 370438007414 dimer interface [polypeptide binding]; other site 370438007415 [2Fe-2S] cluster binding site [ion binding]; other site 370438007416 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 370438007417 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 370438007418 SLBB domain; Region: SLBB; pfam10531 370438007419 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 370438007420 4Fe-4S binding domain; Region: Fer4; cl02805 370438007421 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 370438007422 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 370438007423 putative dimer interface [polypeptide binding]; other site 370438007424 [2Fe-2S] cluster binding site [ion binding]; other site 370438007425 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 370438007426 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 370438007427 ACT domain-containing protein [General function prediction only]; Region: COG4747 370438007428 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 370438007429 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 370438007430 Radical SAM superfamily; Region: Radical_SAM; pfam04055 370438007431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438007432 FeS/SAM binding site; other site 370438007433 Protein of unknown function (DUF512); Region: DUF512; pfam04459 370438007434 UGMP family protein; Validated; Region: PRK09604 370438007435 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 370438007436 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 370438007437 Thioesterase domain; Region: Thioesterase; pfam00975 370438007438 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 370438007439 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 370438007440 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438007441 active site 370438007442 DNA binding site [nucleotide binding] 370438007443 Int/Topo IB signature motif; other site 370438007444 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 370438007445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438007446 active site 370438007447 DNA binding site [nucleotide binding] 370438007448 Int/Topo IB signature motif; other site 370438007449 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 370438007450 Rhomboid family; Region: Rhomboid; cl11446 370438007451 NAD-dependent deacetylase; Provisional; Region: PRK00481 370438007452 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 370438007453 NAD+ binding site [chemical binding]; other site 370438007454 substrate binding site [chemical binding]; other site 370438007455 Zn binding site [ion binding]; other site 370438007456 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 370438007457 Ligand Binding Site [chemical binding]; other site 370438007458 Restriction endonuclease; Region: Mrr_cat; cl00516 370438007459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007460 XcyI restriction endonuclease; Region: RE_XcyI; pfam09571 370438007461 DDE superfamily endonuclease; Region: DDE_5; cl02413 370438007462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370438007463 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 370438007464 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 370438007465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438007466 catalytic residue [active] 370438007467 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 370438007468 nudix motif; other site 370438007469 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 370438007470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438007471 Zn2+ binding site [ion binding]; other site 370438007472 Mg2+ binding site [ion binding]; other site 370438007473 NlpC/P60 family; Region: NLPC_P60; cl11438 370438007474 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 370438007475 active site clefts [active] 370438007476 zinc binding site [ion binding]; other site 370438007477 dimer interface [polypeptide binding]; other site 370438007478 FAT domain; Region: FAT; pfam02259 370438007479 RmuC family; Region: RmuC; pfam02646 370438007480 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 370438007481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438007482 S-adenosylmethionine binding site [chemical binding]; other site 370438007483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 370438007484 ligand binding site [chemical binding]; other site 370438007485 flexible hinge region; other site 370438007486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 370438007487 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 370438007488 YKOF-related Family; Region: Ykof; pfam07615 370438007489 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 370438007490 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 370438007491 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007492 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 370438007494 Helix-turn-helix domains; Region: HTH; cl00088 370438007495 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 370438007496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 370438007497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370438007498 dimerization interface [polypeptide binding]; other site 370438007499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438007500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370438007501 dimer interface [polypeptide binding]; other site 370438007502 phosphorylation site [posttranslational modification] 370438007503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370438007504 ATP binding site [chemical binding]; other site 370438007505 Mg2+ binding site [ion binding]; other site 370438007506 G-X-G motif; other site 370438007507 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370438007508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438007509 active site 370438007510 phosphorylation site [posttranslational modification] 370438007511 intermolecular recognition site; other site 370438007512 dimerization interface [polypeptide binding]; other site 370438007513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370438007514 DNA binding site [nucleotide binding] 370438007515 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 370438007516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 370438007517 active site 370438007518 catalytic tetrad [active] 370438007519 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438007520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370438007521 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 370438007522 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 370438007523 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 370438007524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007525 Protein of unknown function (DUF342); Region: DUF342; pfam03961 370438007526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438007527 Zn2+ binding site [ion binding]; other site 370438007528 Mg2+ binding site [ion binding]; other site 370438007529 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 370438007530 putative active site [active] 370438007531 Protein of unknown function DUF45; Region: DUF45; cl00636 370438007532 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 370438007533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007534 HsdM N-terminal domain; Region: HsdM_N; pfam12161 370438007535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007536 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370438007537 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 370438007538 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 370438007539 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 370438007540 DNA binding residues [nucleotide binding] 370438007541 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 370438007542 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 370438007543 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 370438007544 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438007545 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 370438007546 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 370438007547 putative [Fe4-S4] binding site [ion binding]; other site 370438007548 putative molybdopterin cofactor binding site [chemical binding]; other site 370438007549 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 370438007550 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 370438007551 putative molybdopterin cofactor binding site; other site 370438007552 Recombinase; Region: Recombinase; pfam07508 370438007553 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370438007554 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 370438007555 SmpB-tmRNA interface; other site 370438007556 Helix-turn-helix domains; Region: HTH; cl00088 370438007557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370438007558 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 370438007559 CoenzymeA binding site [chemical binding]; other site 370438007560 subunit interaction site [polypeptide binding]; other site 370438007561 PHB binding site; other site 370438007562 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 370438007563 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 370438007564 Preprotein translocase SecG subunit; Region: SecG; cl09123 370438007565 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370438007566 metal binding site [ion binding]; metal-binding site 370438007567 substrate binding pocket [chemical binding]; other site 370438007568 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 370438007569 dimer interface [polypeptide binding]; other site 370438007570 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 370438007571 Sulfatase; Region: Sulfatase; cl10460 370438007572 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 370438007573 substrate binding site [chemical binding]; other site 370438007574 dimer interface [polypeptide binding]; other site 370438007575 catalytic triad [active] 370438007576 Phosphoglycerate kinase; Region: PGK; pfam00162 370438007577 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 370438007578 substrate binding site [chemical binding]; other site 370438007579 hinge regions; other site 370438007580 ADP binding site [chemical binding]; other site 370438007581 catalytic site [active] 370438007582 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 370438007583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007584 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 370438007585 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 370438007586 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 370438007587 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 370438007588 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 370438007589 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 370438007590 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 370438007591 trimer interface [polypeptide binding]; other site 370438007592 active site 370438007593 substrate binding site [chemical binding]; other site 370438007594 CoA binding site [chemical binding]; other site 370438007595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 370438007596 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 370438007597 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 370438007598 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 370438007599 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 370438007600 phosphate binding site [ion binding]; other site 370438007601 putative substrate binding pocket [chemical binding]; other site 370438007602 dimer interface [polypeptide binding]; other site 370438007603 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 370438007604 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 370438007605 putative hydrolase; Validated; Region: PRK09248 370438007606 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 370438007607 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 370438007608 active site 370438007609 dimer interface [polypeptide binding]; other site 370438007610 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 370438007611 dimer interface [polypeptide binding]; other site 370438007612 active site 370438007613 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 370438007614 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 370438007615 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370438007616 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370438007617 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370438007618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370438007619 motif II; other site 370438007620 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370438007621 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 370438007622 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 370438007623 GIY-YIG motif/motif A; other site 370438007624 active site 370438007625 catalytic site [active] 370438007626 putative DNA binding site [nucleotide binding]; other site 370438007627 metal binding site [ion binding]; metal-binding site 370438007628 UvrB/uvrC motif; Region: UVR; pfam02151 370438007629 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 370438007630 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 370438007631 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 370438007632 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 370438007633 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 370438007634 excinuclease ABC subunit B; Provisional; Region: PRK05298 370438007635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370438007636 ATP binding site [chemical binding]; other site 370438007637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370438007638 nucleotide binding region [chemical binding]; other site 370438007639 ATP-binding site [chemical binding]; other site 370438007640 Ultra-violet resistance protein B; Region: UvrB; pfam12344 370438007641 UvrB/uvrC motif; Region: UVR; pfam02151 370438007642 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 370438007643 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 370438007644 ligand binding site [chemical binding]; other site 370438007645 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 370438007646 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 370438007647 Fe-S cluster binding site [ion binding]; other site 370438007648 active site 370438007649 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 370438007650 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 370438007651 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 370438007652 C-terminal peptidase (prc); Region: prc; TIGR00225 370438007653 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 370438007654 protein binding site [polypeptide binding]; other site 370438007655 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 370438007656 Catalytic dyad [active] 370438007657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 370438007658 Peptidase family M23; Region: Peptidase_M23; pfam01551 370438007659 FtsX-like permease family; Region: FtsX; cl15850 370438007660 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 370438007661 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007662 Walker A/P-loop; other site 370438007663 ATP binding site [chemical binding]; other site 370438007664 Q-loop/lid; other site 370438007665 ABC transporter signature motif; other site 370438007666 Walker B; other site 370438007667 D-loop; other site 370438007668 H-loop/switch region; other site 370438007669 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 370438007670 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 370438007671 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 370438007672 PYR/PP interface [polypeptide binding]; other site 370438007673 dimer interface [polypeptide binding]; other site 370438007674 TPP binding site [chemical binding]; other site 370438007675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 370438007676 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 370438007677 TPP-binding site [chemical binding]; other site 370438007678 dimer interface [polypeptide binding]; other site 370438007679 Uncharacterized conserved protein [Function unknown]; Region: COG1284 370438007680 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370438007681 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370438007682 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370438007683 peptide chain release factor 2; Validated; Region: prfB; PRK00578 370438007684 RF-1 domain; Region: RF-1; cl02875 370438007685 RF-1 domain; Region: RF-1; cl02875 370438007686 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 370438007687 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007688 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 370438007689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007690 nucleotide binding region [chemical binding]; other site 370438007691 SEC-C motif; Region: SEC-C; pfam02810 370438007692 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 370438007693 30S subunit binding site; other site 370438007694 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 370438007695 DNA-binding site [nucleotide binding]; DNA binding site 370438007696 RNA-binding motif; other site 370438007697 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 370438007698 GAF domain; Region: GAF; cl15785 370438007699 GAF domain; Region: GAF_2; pfam13185 370438007700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 370438007701 metal binding site [ion binding]; metal-binding site 370438007702 active site 370438007703 I-site; other site 370438007704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 370438007705 active site 370438007706 S-adenosylmethionine synthetase; Validated; Region: PRK05250 370438007707 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 370438007708 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 370438007709 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 370438007710 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370438007711 integral membrane protein MviN; Region: mviN; TIGR01695 370438007712 MatE; Region: MatE; cl10513 370438007713 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 370438007714 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 370438007715 active site 370438007716 substrate binding site [chemical binding]; other site 370438007717 metal binding site [ion binding]; metal-binding site 370438007718 Protein of unknown function (DUF421); Region: DUF421; cl00990 370438007719 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 370438007720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438007721 NAD(P) binding site [chemical binding]; other site 370438007722 active site 370438007723 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 370438007724 active site 370438007725 tetramer interface; other site 370438007726 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 370438007727 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 370438007728 Mg++ binding site [ion binding]; other site 370438007729 putative catalytic motif [active] 370438007730 substrate binding site [chemical binding]; other site 370438007731 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 370438007732 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 370438007733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 370438007734 putative homodimer interface [polypeptide binding]; other site 370438007735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370438007736 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370438007737 O-Antigen ligase; Region: Wzy_C; cl04850 370438007738 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 370438007739 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 370438007740 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 370438007741 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 370438007742 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 370438007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438007744 putative substrate translocation pore; other site 370438007745 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438007746 HicB family; Region: HicB; pfam05534 370438007747 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 370438007748 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 370438007749 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 370438007750 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007751 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007752 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 370438007753 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007754 Helix-turn-helix domains; Region: HTH; cl00088 370438007755 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438007756 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438007757 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 370438007758 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 370438007759 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 370438007760 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 370438007761 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 370438007762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370438007763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370438007764 DNA binding residues [nucleotide binding] 370438007765 Putative zinc-finger; Region: zf-HC2; cl15806 370438007766 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 370438007767 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 370438007768 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 370438007769 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 370438007770 putative active site [active] 370438007771 S-layer homology domain; Region: SLH; pfam00395 370438007772 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 370438007773 active site 370438007774 catalytic triad [active] 370438007775 rod shape-determining protein Mbl; Provisional; Region: PRK13928 370438007776 Cell division protein FtsA; Region: FtsA; cl11496 370438007777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370438007778 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 370438007779 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007780 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370438007781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438007782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370438007783 Walker A/P-loop; other site 370438007784 ATP binding site [chemical binding]; other site 370438007785 Q-loop/lid; other site 370438007786 ABC transporter signature motif; other site 370438007787 Walker B; other site 370438007788 D-loop; other site 370438007789 H-loop/switch region; other site 370438007790 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 370438007791 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438007792 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 370438007793 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370438007794 S-layer homology domain; Region: SLH; pfam00395 370438007795 S-layer homology domain; Region: SLH; pfam00395 370438007796 S-layer homology domain; Region: SLH; pfam00395 370438007797 FecR protein; Region: FecR; pfam04773 370438007798 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 370438007799 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 370438007800 Leucine rich repeat; Region: LRR_8; pfam13855 370438007801 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 370438007802 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 370438007803 ligand binding site [chemical binding]; other site 370438007804 flexible hinge region; other site 370438007805 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 370438007806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438007807 Walker A motif; other site 370438007808 ATP binding site [chemical binding]; other site 370438007809 Walker B motif; other site 370438007810 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 370438007811 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 370438007812 putative active site [active] 370438007813 stage II sporulation protein D; Region: spore_II_D; TIGR02870 370438007814 Stage II sporulation protein; Region: SpoIID; pfam08486 370438007815 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 370438007816 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 370438007817 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 370438007818 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370438007819 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 370438007820 alpha subunit interaction interface [polypeptide binding]; other site 370438007821 Walker A motif; other site 370438007822 ATP binding site [chemical binding]; other site 370438007823 Walker B motif; other site 370438007824 inhibitor binding site; inhibition site 370438007825 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 370438007826 ATP synthase; Region: ATP-synt; cl00365 370438007827 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 370438007828 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 370438007829 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370438007830 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 370438007831 beta subunit interaction interface [polypeptide binding]; other site 370438007832 Walker A motif; other site 370438007833 ATP binding site [chemical binding]; other site 370438007834 Walker B motif; other site 370438007835 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 370438007836 Plant ATP synthase F0; Region: YMF19; cl07975 370438007837 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 370438007838 Plant ATP synthase F0; Region: YMF19; cl07975 370438007839 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 370438007840 ATP synthase subunit C; Region: ATP-synt_C; cl00466 370438007841 ATP synthase A chain; Region: ATP-synt_A; cl00413 370438007842 ATP synthase I chain; Region: ATP_synt_I; cl09170 370438007843 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 370438007844 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 370438007845 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 370438007846 active site 370438007847 homodimer interface [polypeptide binding]; other site 370438007848 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 370438007849 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 370438007850 catalytic motif [active] 370438007851 Zn binding site [ion binding]; other site 370438007852 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 370438007853 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 370438007854 dimer interface [polypeptide binding]; other site 370438007855 active site 370438007856 glycine-pyridoxal phosphate binding site [chemical binding]; other site 370438007857 folate binding site [chemical binding]; other site 370438007858 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 370438007859 Low molecular weight phosphatase family; Region: LMWPc; cd00115 370438007860 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 370438007861 active site 370438007862 Predicted membrane protein [Function unknown]; Region: COG1971 370438007863 Domain of unknown function DUF; Region: DUF204; pfam02659 370438007864 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 370438007865 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 370438007866 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 370438007867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370438007868 S-adenosylmethionine binding site [chemical binding]; other site 370438007869 peptide chain release factor 1; Validated; Region: prfA; PRK00591 370438007870 RF-1 domain; Region: RF-1; cl02875 370438007871 RF-1 domain; Region: RF-1; cl02875 370438007872 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 370438007873 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 370438007874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438007875 Radical SAM superfamily; Region: Radical_SAM; pfam04055 370438007876 FeS/SAM binding site; other site 370438007877 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438007878 putative peptidoglycan binding site; other site 370438007879 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 370438007880 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438007881 putative peptidoglycan binding site; other site 370438007882 Peptidase family M23; Region: Peptidase_M23; pfam01551 370438007883 transcription termination factor Rho; Provisional; Region: rho; PRK09376 370438007884 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 370438007885 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 370438007886 RNA binding site [nucleotide binding]; other site 370438007887 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 370438007888 multimer interface [polypeptide binding]; other site 370438007889 Walker A motif; other site 370438007890 ATP binding site [chemical binding]; other site 370438007891 Walker B motif; other site 370438007892 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 370438007893 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 370438007894 active site 370438007895 intersubunit interactions; other site 370438007896 catalytic residue [active] 370438007897 hypothetical protein; Provisional; Region: PRK08185 370438007898 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 370438007899 intersubunit interface [polypeptide binding]; other site 370438007900 active site 370438007901 zinc binding site [ion binding]; other site 370438007902 Na+ binding site [ion binding]; other site 370438007903 Response regulator receiver domain; Region: Response_reg; pfam00072 370438007904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370438007905 active site 370438007906 phosphorylation site [posttranslational modification] 370438007907 intermolecular recognition site; other site 370438007908 dimerization interface [polypeptide binding]; other site 370438007909 Yip1 domain; Region: Yip1; cl12048 370438007910 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 370438007911 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 370438007912 tandem repeat interface [polypeptide binding]; other site 370438007913 oligomer interface [polypeptide binding]; other site 370438007914 active site residues [active] 370438007915 CTP synthetase; Validated; Region: pyrG; PRK05380 370438007916 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 370438007917 Catalytic site [active] 370438007918 active site 370438007919 UTP binding site [chemical binding]; other site 370438007920 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 370438007921 active site 370438007922 putative oxyanion hole; other site 370438007923 catalytic triad [active] 370438007924 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 370438007925 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 370438007926 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 370438007927 active site 370438007928 HIGH motif; other site 370438007929 KMSK motif region; other site 370438007930 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 370438007931 tRNA binding surface [nucleotide binding]; other site 370438007932 anticodon binding site; other site 370438007933 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 370438007934 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 370438007935 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 370438007936 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 370438007937 dimer interface [polypeptide binding]; other site 370438007938 PYR/PP interface [polypeptide binding]; other site 370438007939 TPP binding site [chemical binding]; other site 370438007940 substrate binding site [chemical binding]; other site 370438007941 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 370438007942 TPP-binding site; other site 370438007943 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370438007944 AMP-binding enzyme; Region: AMP-binding; cl15778 370438007945 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 370438007946 AMP-binding enzyme; Region: AMP-binding; cl15778 370438007947 Sodium:solute symporter family; Region: SSF; cl00456 370438007948 hypothetical protein; Validated; Region: PRK07682 370438007949 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370438007950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370438007951 homodimer interface [polypeptide binding]; other site 370438007952 catalytic residue [active] 370438007953 Helix-turn-helix domains; Region: HTH; cl00088 370438007954 Sodium:solute symporter family; Region: SSF; cl00456 370438007955 germination protein YpeB; Region: spore_YpeB; TIGR02889 370438007956 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 370438007957 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 370438007958 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 370438007959 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 370438007960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438007961 dimer interface [polypeptide binding]; other site 370438007962 putative CheW interface [polypeptide binding]; other site 370438007963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 370438007964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 370438007965 dimer interface [polypeptide binding]; other site 370438007966 putative CheW interface [polypeptide binding]; other site 370438007967 DsrC like protein; Region: DsrC; cl01101 370438007968 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 370438007969 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 370438007970 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 370438007971 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 370438007972 hinge; other site 370438007973 active site 370438007974 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 370438007975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 370438007976 binding surface 370438007977 Tetratricopeptide repeat; Region: TPR_16; pfam13432 370438007978 TPR motif; other site 370438007979 Tetratricopeptide repeat; Region: TPR_16; pfam13432 370438007980 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 370438007981 putative peptidoglycan binding site; other site 370438007982 G5 domain; Region: G5; pfam07501 370438007983 Peptidase family M23; Region: Peptidase_M23; pfam01551 370438007984 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 370438007985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370438007986 FeS/SAM binding site; other site 370438007987 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 370438007988 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 370438007989 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370438007990 active site 370438007991 HIGH motif; other site 370438007992 nucleotide binding site [chemical binding]; other site 370438007993 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 370438007994 KMSKS motif; other site 370438007995 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 370438007996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370438007997 Zn2+ binding site [ion binding]; other site 370438007998 Mg2+ binding site [ion binding]; other site 370438007999 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 370438008000 PAS domain S-box; Region: sensory_box; TIGR00229 370438008001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 370438008002 putative active site [active] 370438008003 heme pocket [chemical binding]; other site 370438008004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 370438008005 GAF domain; Region: GAF; cl15785 370438008006 GAF domain; Region: GAF_2; pfam13185 370438008007 GAF domain; Region: GAF; cl15785 370438008008 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional; Region: PRK06259 370438008009 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 370438008010 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 370438008011 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 370438008012 CHC2 zinc finger; Region: zf-CHC2; cl15369 370438008013 hypothetical protein; Validated; Region: PRK07078 370438008014 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 370438008015 active site 370438008016 metal binding site [ion binding]; metal-binding site 370438008017 interdomain interaction site; other site 370438008018 AAA domain; Region: AAA_25; pfam13481 370438008019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370438008020 Walker A motif; other site 370438008021 ATP binding site [chemical binding]; other site 370438008022 Walker B motif; other site 370438008023 chromosome segregation protein; Provisional; Region: PRK03918 370438008024 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370438008025 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 370438008026 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 370438008027 GDP-binding site [chemical binding]; other site 370438008028 ACT binding site; other site 370438008029 IMP binding site; other site 370438008030 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 370438008031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438008032 replicative DNA helicase; Region: DnaB; TIGR00665 370438008033 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 370438008034 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 370438008035 Walker A motif; other site 370438008036 ATP binding site [chemical binding]; other site 370438008037 Walker B motif; other site 370438008038 DNA binding loops [nucleotide binding] 370438008039 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 370438008040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438008041 Walker A motif; other site 370438008042 ATP binding site [chemical binding]; other site 370438008043 Walker B motif; other site 370438008044 arginine finger; other site 370438008045 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370438008046 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 370438008047 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 370438008048 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 370438008049 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 370438008050 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 370438008051 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 370438008052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 370438008053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 370438008054 dimer interface [polypeptide binding]; other site 370438008055 ssDNA binding site [nucleotide binding]; other site 370438008056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370438008057 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 370438008058 benzoate transport; Region: 2A0115; TIGR00895 370438008059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438008060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370438008061 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 370438008062 classical (c) SDRs; Region: SDR_c; cd05233 370438008063 NAD(P) binding site [chemical binding]; other site 370438008064 active site 370438008065 Putative cyclase; Region: Cyclase; cl00814 370438008066 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 370438008067 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 370438008068 putative active site [active] 370438008069 metal binding site [ion binding]; metal-binding site 370438008070 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 370438008071 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 370438008072 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 370438008073 Ubiquitin-like proteins; Region: UBQ; cl00155 370438008074 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 370438008075 Malic enzyme, N-terminal domain; Region: malic; pfam00390 370438008076 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 370438008077 putative NAD(P) binding site [chemical binding]; other site 370438008078 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 370438008079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370438008080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370438008081 Walker A motif; other site 370438008082 ATP binding site [chemical binding]; other site 370438008083 Walker B motif; other site 370438008084 arginine finger; other site 370438008085 Helix-turn-helix domains; Region: HTH; cl00088 370438008086 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 370438008087 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 370438008088 Mechanosensitive ion channel; Region: MS_channel; pfam00924 370438008089 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 370438008090 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 370438008091 oligomer interface [polypeptide binding]; other site 370438008092 putative active site [active] 370438008093 metal binding site [ion binding]; metal-binding site 370438008094 Transposase IS200 like; Region: Y1_Tnp; cl00848 370438008095 Colicin V production protein; Region: Colicin_V; cl00567 370438008096 Colicin V production protein; Region: Colicin_V; cl00567 370438008097 Uncharacterized membrane protein [Function unknown]; Region: COG3949 370438008098 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 370438008099 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 370438008100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370438008101 active site 370438008102 Protein of unknown function DUF111; Region: DUF111; cl03398 370438008103 Protein of unknown function (DUF554); Region: DUF554; cl00784 370438008104 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 370438008105 ParB-like nuclease domain; Region: ParBc; cl02129 370438008106 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 370438008107 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 370438008108 P-loop; other site 370438008109 Magnesium ion binding site [ion binding]; other site 370438008110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 370438008111 Magnesium ion binding site [ion binding]; other site 370438008112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 370438008113 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 370438008114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370438008115 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 370438008116 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 370438008117 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 370438008118 trmE is a tRNA modification GTPase; Region: trmE; cd04164 370438008119 G1 box; other site 370438008120 GTP/Mg2+ binding site [chemical binding]; other site 370438008121 Switch I region; other site 370438008122 G2 box; other site 370438008123 Switch II region; other site 370438008124 G3 box; other site 370438008125 G4 box; other site 370438008126 G5 box; other site 370438008127 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 370438008128 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 370438008129 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 370438008130 G-X-X-G motif; other site 370438008131 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 370438008132 RxxxH motif; other site 370438008133 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 370438008134 Ribonuclease P; Region: Ribonuclease_P; cl00457