-- dump date   	20120504_154904
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
365044000001	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044000002	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044000003	catalytic residues [active]
365044000004	catalytic nucleophile [active]
365044000005	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044000006	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044000007	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044000008	Synaptic Site I dimer interface [polypeptide binding]; other site
365044000009	DNA binding site [nucleotide binding]
365044000010	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365044000011	DNA-binding interface [nucleotide binding]; DNA binding site
365044000012	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
365044000013	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
365044000014	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000015	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
365044000016	active site
365044000017	metal binding site [ion binding]; metal-binding site
365044000018	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044000019	putative active site [active]
365044000020	catalytic site [active]
365044000021	Helix-turn-helix domains; Region: HTH; cl00088
365044000022	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044000023	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000024	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000025	zinc-finger of acetyl-transferase ESCO; Region: zf-C2H2_3; pfam13878
365044000026	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
365044000027	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000028	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365044000029	active site
365044000030	DNA binding site [nucleotide binding]
365044000031	Int/Topo IB signature motif; other site
365044000032	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
365044000033	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044000034	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044000035	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
365044000036	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044000037	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
365044000038	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
365044000039	active site
365044000040	catalytic residues [active]
365044000041	metal binding site [ion binding]; metal-binding site
365044000042	DmpG-like communication domain; Region: DmpG_comm; pfam07836
365044000043	acetaldehyde dehydrogenase; Validated; Region: PRK08300
365044000044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044000045	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
365044000046	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044000047	glutathionine S-transferase; Provisional; Region: PRK10542
365044000048	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
365044000049	C-terminal domain interface [polypeptide binding]; other site
365044000050	GSH binding site (G-site) [chemical binding]; other site
365044000051	dimer interface [polypeptide binding]; other site
365044000052	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
365044000053	dimer interface [polypeptide binding]; other site
365044000054	N-terminal domain interface [polypeptide binding]; other site
365044000055	substrate binding pocket (H-site) [chemical binding]; other site
365044000056	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
365044000057	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
365044000058	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
365044000059	active site
365044000060	Fe binding site [ion binding]; other site
365044000061	cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Region: BphB_TodD; TIGR03325
365044000062	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
365044000063	NAD binding site [chemical binding]; other site
365044000064	active site
365044000065	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
365044000066	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044000067	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
365044000068	[2Fe-2S] cluster binding site [ion binding]; other site
365044000069	BphX-like; Region: BphX; pfam06139
365044000070	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044000071	inter-subunit interface; other site
365044000072	Rieske non-heme iron oxygenase (RO) family, Biphenyl dioxygenase (BPDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of BPDO and similar proteins including cumene dioxygenase (CumDO); Region: Rieske_RO_Alpha_BPDO_like; cd03472
365044000073	beta subunit interaction site [polypeptide binding]; other site
365044000074	alpha subunit interaction site [polypeptide binding]; other site
365044000075	iron-sulfur cluster [ion binding]; other site
365044000076	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
365044000077	beta subunit interface [polypeptide binding]; other site
365044000078	alpha subunit interface [polypeptide binding]; other site
365044000079	active site
365044000080	substrate binding site [chemical binding]; other site
365044000081	Fe binding site [ion binding]; other site
365044000082	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
365044000083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044000084	DNA-binding site [nucleotide binding]; DNA binding site
365044000085	FCD domain; Region: FCD; cl11656
365044000086	Abortive infection C-terminus; Region: Abi_C; pfam14355
365044000087	Domain of unknown function (DUF932); Region: DUF932; cl12129
365044000088	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
365044000089	MPN+ (JAMM) motif; other site
365044000090	Zinc-binding site [ion binding]; other site
365044000091	ParB-like nuclease domain; Region: ParBc; cl02129
365044000092	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
365044000093	Protein of unknown function (DUF736); Region: DUF736; cl02303
365044000094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044000095	non-specific DNA binding site [nucleotide binding]; other site
365044000096	salt bridge; other site
365044000097	sequence-specific DNA binding site [nucleotide binding]; other site
365044000098	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
365044000099	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
365044000100	Replication initiator protein A; Region: RPA; cl02339
365044000101	ParA-like protein; Provisional; Region: PHA02518
365044000102	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000103	P-loop; other site
365044000104	Magnesium ion binding site [ion binding]; other site
365044000105	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
365044000106	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
365044000107	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
365044000108	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
365044000109	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
365044000110	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044000111	Helix-turn-helix domains; Region: HTH; cl00088
365044000112	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
365044000113	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044000114	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
365044000115	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365044000116	hypothetical protein; Provisional; Region: PRK10279
365044000117	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
365044000118	nucleophile elbow; other site
365044000119	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
365044000120	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044000121	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044000122	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044000123	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044000124	Protein export membrane protein; Region: SecD_SecF; cl14618
365044000125	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
365044000126	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
365044000127	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
365044000128	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044000129	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044000130	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
365044000131	catalytic loop [active]
365044000132	iron binding site [ion binding]; other site
365044000133	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213
365044000134	FAD binding pocket [chemical binding]; other site
365044000135	FAD binding motif [chemical binding]; other site
365044000136	phosphate binding motif [ion binding]; other site
365044000137	beta-alpha-beta structure motif; other site
365044000138	NAD binding pocket [chemical binding]; other site
365044000139	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
365044000140	Fatty acid desaturase; Region: FA_desaturase; pfam00487
365044000141	Di-iron ligands [ion binding]; other site
365044000142	choline dehydrogenase; Validated; Region: PRK02106
365044000143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044000144	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
365044000145	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
365044000146	AMP-binding enzyme; Region: AMP-binding; cl15778
365044000147	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044000148	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044000149	NAD(P) binding site [chemical binding]; other site
365044000150	catalytic residues [active]
365044000151	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044000152	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
365044000153	Helix-turn-helix domains; Region: HTH; cl00088
365044000154	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
365044000155	dimerization interface [polypeptide binding]; other site
365044000156	substrate binding pocket [chemical binding]; other site
365044000157	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
365044000158	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
365044000159	Walker A motif; other site
365044000160	ATP binding site [chemical binding]; other site
365044000161	Walker B motif; other site
365044000162	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
365044000163	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
365044000164	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
365044000165	ATP binding site [chemical binding]; other site
365044000166	Walker A motif; other site
365044000167	hexamer interface [polypeptide binding]; other site
365044000168	Walker B motif; other site
365044000169	TrbC/VIRB2 family; Region: TrbC; cl01583
365044000170	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
365044000171	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
365044000172	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
365044000173	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
365044000174	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
365044000175	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
365044000176	conjugal transfer protein TrbL; Provisional; Region: PRK13875
365044000177	VirB8 protein; Region: VirB8; cl01500
365044000178	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
365044000179	VirB7 interaction site; other site
365044000180	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
365044000181	Protein of unknown function (DUF2274); Region: DUF2274; cl02406
365044000182	Protein of unknown function (DUF805); Region: DUF805; cl01224
365044000183	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044000184	Active Sites [active]
365044000185	H-NS histone family; Region: Histone_HNS; pfam00816
365044000186	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
365044000187	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
365044000188	Restriction endonuclease; Region: Mrr_cat; cl00516
365044000189	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
365044000190	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000191	Walker A motif; other site
365044000192	ATP binding site [chemical binding]; other site
365044000193	Walker B motif; other site
365044000194	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
365044000195	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
365044000196	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
365044000197	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
365044000198	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
365044000199	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
365044000200	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
365044000201	Type II/IV secretion system protein; Region: T2SE; pfam00437
365044000202	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000203	Walker A motif; other site
365044000204	ATP binding site [chemical binding]; other site
365044000205	Walker B motif; other site
365044000206	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
365044000207	VirB8 protein; Region: VirB8; cl01500
365044000208	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
365044000209	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
365044000210	VirB7 interaction site; other site
365044000211	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
365044000212	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000213	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000214	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044000215	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044000216	catalytic residue [active]
365044000217	Initiator Replication protein; Region: Rep_3; cl03080
365044000218	Transposase domain (DUF772); Region: DUF772; pfam05598
365044000219	ParB-like partition proteins; Region: parB_part; TIGR00180
365044000220	ParB-like nuclease domain; Region: ParBc; cl02129
365044000221	ParA-like protein; Provisional; Region: PHA02518
365044000222	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000223	P-loop; other site
365044000224	Magnesium ion binding site [ion binding]; other site
365044000225	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000226	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000227	Phage integrase protein; Region: DUF3701; pfam12482
365044000228	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
365044000229	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000230	active site
365044000231	Int/Topo IB signature motif; other site
365044000232	DNA binding site [nucleotide binding]
365044000233	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
365044000234	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044000235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000236	Walker A motif; other site
365044000237	ATP binding site [chemical binding]; other site
365044000238	Walker B motif; other site
365044000239	arginine finger; other site
365044000240	Helix-turn-helix domains; Region: HTH; cl00088
365044000241	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
365044000242	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044000243	metal ion-dependent adhesion site (MIDAS); other site
365044000244	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
365044000245	Protein kinase domain; Region: Pkinase; pfam00069
365044000246	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044000247	active site
365044000248	ATP binding site [chemical binding]; other site
365044000249	substrate binding site [chemical binding]; other site
365044000250	activation loop (A-loop); other site
365044000251	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044000252	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000253	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000254	Family description; Region: UvrD_C_2; cl15862
365044000255	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044000256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000257	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
365044000258	homodimer interface [polypeptide binding]; other site
365044000259	putative active site [active]
365044000260	catalytic site [active]
365044000261	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
365044000262	putative homodimer interface [polypeptide binding]; other site
365044000263	putative active site [active]
365044000264	catalytic site [active]
365044000265	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
365044000266	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000267	ATP binding site [chemical binding]; other site
365044000268	putative Mg++ binding site [ion binding]; other site
365044000269	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044000270	nucleotide binding region [chemical binding]; other site
365044000271	ATP-binding site [chemical binding]; other site
365044000272	Restriction endonuclease; Region: Mrr_cat; cl00516
365044000273	cell division protein DamX; Validated; Region: PRK10905
365044000274	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044000275	ligand binding site [chemical binding]; other site
365044000276	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
365044000277	DNA binding site [nucleotide binding]
365044000278	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
365044000279	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
365044000280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000281	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044000282	Walker A motif; other site
365044000283	ATP binding site [chemical binding]; other site
365044000284	Walker B motif; other site
365044000285	arginine finger; other site
365044000286	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000287	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000288	Family description; Region: UvrD_C_2; cl15862
365044000289	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
365044000290	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000291	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365044000292	putative active site [active]
365044000293	putative metal-binding site [ion binding]; other site
365044000294	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
365044000295	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000296	ATP binding site [chemical binding]; other site
365044000297	putative Mg++ binding site [ion binding]; other site
365044000298	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044000299	nucleotide binding region [chemical binding]; other site
365044000300	ATP-binding site [chemical binding]; other site
365044000301	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
365044000302	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000303	primosomal protein DnaI; Reviewed; Region: PRK08939
365044000304	AAA domain; Region: AAA_21; pfam13304
365044000305	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000306	Walker B; other site
365044000307	D-loop; other site
365044000308	H-loop/switch region; other site
365044000309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044000310	Restriction endonuclease; Region: Mrr_cat; cl00516
365044000311	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044000312	active site
365044000313	ATP binding site [chemical binding]; other site
365044000314	substrate binding site [chemical binding]; other site
365044000315	activation loop (A-loop); other site
365044000316	Protein kinase domain; Region: Pkinase; pfam00069
365044000317	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044000318	active site
365044000319	ATP binding site [chemical binding]; other site
365044000320	substrate binding site [chemical binding]; other site
365044000321	activation loop (A-loop); other site
365044000322	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044000323	Protein of unknown function DUF262; Region: DUF262; cl14890
365044000324	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044000325	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
365044000326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000327	Walker A motif; other site
365044000328	ATP binding site [chemical binding]; other site
365044000329	Walker B motif; other site
365044000330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000331	Integrase core domain; Region: rve; cl01316
365044000332	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000333	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
365044000334	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
365044000335	ParB-like nuclease domain; Region: ParBc; cl02129
365044000336	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
365044000337	PRTRC system protein F; Region: PRTRC_F; TIGR03742
365044000338	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
365044000339	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
365044000340	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
365044000341	PRTRC system protein A; Region: PRTRC_A; TIGR03735
365044000342	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
365044000343	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
365044000344	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
365044000345	ATP binding site [chemical binding]; other site
365044000346	substrate interface [chemical binding]; other site
365044000347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044000348	S-adenosylmethionine binding site [chemical binding]; other site
365044000349	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
365044000350	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000351	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000352	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
365044000354	Peptidase M15; Region: Peptidase_M15_3; cl01194
365044000355	Domain of unknown function (DUF932); Region: DUF932; cl12129
365044000356	DNA polymerase sliding clamp subunit (PCNA homolog) [DNA replication, recombination, and repair]; Region: DnaN; COG0592
365044000357	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl02940
365044000358	putative DNA binding surface [nucleotide binding]; other site
365044000359	dimer interface [polypeptide binding]; other site
365044000360	beta-clamp/clamp loader binding surface; other site
365044000361	beta-clamp/translesion DNA polymerase binding surface; other site
365044000362	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044000363	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
365044000364	Predicted transcriptional regulator [Transcription]; Region: COG2944
365044000365	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000366	AAA domain; Region: AAA_18; pfam13238
365044000367	active site
365044000368	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000369	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000370	Family description; Region: UvrD_C_2; cl15862
365044000371	ParB-like nuclease domain; Region: ParBc; cl02129
365044000372	KorB domain; Region: KorB; pfam08535
365044000373	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044000374	active site
365044000375	metal binding site [ion binding]; metal-binding site
365044000376	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
365044000377	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000378	Q-loop/lid; other site
365044000379	ABC transporter signature motif; other site
365044000380	Walker B; other site
365044000381	D-loop; other site
365044000382	H-loop/switch region; other site
365044000383	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044000384	dimer interface [polypeptide binding]; other site
365044000385	ssDNA binding site [nucleotide binding]; other site
365044000386	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044000387	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
365044000388	CHC2 zinc finger; Region: zf-CHC2; cl15369
365044000389	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
365044000390	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
365044000391	DivIVA protein; Region: DivIVA; pfam05103
365044000392	Putative helicase; Region: TraI_2; pfam07514
365044000393	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
365044000394	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
365044000395	RRXRR protein; Region: RRXRR; pfam14239
365044000396	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
365044000397	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000398	active site
365044000399	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
365044000400	RRXRR protein; Region: RRXRR; pfam14239
365044000401	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000402	active site
365044000403	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
365044000404	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044000405	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000406	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000407	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
365044000408	PRTRC system protein D; Region: PRTRC_D; TIGR03739
365044000409	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
365044000410	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000411	active site
365044000412	catalytic residues [active]
365044000413	DNA binding site [nucleotide binding]
365044000414	Int/Topo IB signature motif; other site
365044000415	AntA/AntB antirepressor; Region: AntA; cl01430
365044000416	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044000417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
365044000418	active site
365044000419	phosphorylation site [posttranslational modification]
365044000420	intermolecular recognition site; other site
365044000421	transcriptional regulator FimZ; Provisional; Region: PRK09935
365044000422	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044000423	DNA binding residues [nucleotide binding]
365044000424	dimerization interface [polypeptide binding]; other site
365044000425	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044000426	Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457
365044000427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044000428	ATP binding site [chemical binding]; other site
365044000429	substrate interface [chemical binding]; other site
365044000430	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023
365044000431	putative transposase OrfB; Reviewed; Region: PHA02517
365044000432	HTH-like domain; Region: HTH_21; pfam13276
365044000433	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000434	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044000435	Helix-turn-helix domains; Region: HTH; cl00088
365044000436	Y-family of DNA polymerases; Region: PolY; cl12025
365044000437	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
365044000438	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
365044000439	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
365044000440	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
365044000441	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044000442	Endonuclease I; Region: Endonuclease_1; cl01003
365044000443	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044000444	Putative phage integrase; Region: Phage_Integr_2; pfam13009
365044000445	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000446	DNA binding site [nucleotide binding]
365044000447	active site
365044000448	Int/Topo IB signature motif; other site
365044000449	catalytic residues [active]
365044000450	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000451	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044000452	active site
365044000453	Mg2+ binding site [ion binding]; other site
365044000454	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
365044000455	ski2-like helicase; Provisional; Region: PRK00254
365044000456	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000457	ATP binding site [chemical binding]; other site
365044000458	putative Mg++ binding site [ion binding]; other site
365044000459	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044000460	nucleotide binding region [chemical binding]; other site
365044000461	ATP-binding site [chemical binding]; other site
365044000462	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000463	AAA domain; Region: AAA_23; pfam13476
365044000464	Walker A/P-loop; other site
365044000465	ATP binding site [chemical binding]; other site
365044000466	AAA ATPase domain; Region: AAA_15; pfam13175
365044000467	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000468	ABC transporter signature motif; other site
365044000469	Walker B; other site
365044000470	D-loop; other site
365044000471	H-loop/switch region; other site
365044000472	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
365044000473	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000474	Family description; Region: UvrD_C_2; cl15862
365044000475	Tim44-like domain; Region: Tim44; cl09208
365044000476	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000477	Integrase core domain; Region: rve; cl01316
365044000478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044000479	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044000480	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
365044000481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000482	Walker A motif; other site
365044000483	ATP binding site [chemical binding]; other site
365044000484	Walker B motif; other site
365044000485	TrfA protein; Region: TrfA; pfam07042
365044000486	Replication initiator protein A; Region: RPA; cl02339
365044000487	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
365044000488	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000489	RRXRR protein; Region: RRXRR; pfam14239
365044000490	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044000491	active site
365044000492	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000493	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
365044000494	putative methyltransferase; Provisional; Region: PRK14968
365044000495	aspartate carbamoyltransferase; Provisional; Region: PRK11891
365044000496	Fic family protein [Function unknown]; Region: COG3177
365044000497	Fic/DOC family; Region: Fic; cl00960
365044000498	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044000499	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000500	DNA binding site [nucleotide binding]
365044000501	active site
365044000502	Int/Topo IB signature motif; other site
365044000503	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
365044000504	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000505	Helix-turn-helix domains; Region: HTH; cl00088
365044000506	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044000507	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044000508	active site
365044000509	substrate binding site [chemical binding]; other site
365044000510	Mg2+ binding site [ion binding]; other site
365044000511	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000512	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
365044000513	active site
365044000514	catalytic residues [active]
365044000515	Dynein, heavy chain [Cytoskeleton]; Region: DYN1; COG5245
365044000516	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000517	Helix-turn-helix domains; Region: HTH; cl00088
365044000518	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044000519	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044000520	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044000521	Integrase core domain; Region: rve; cl01316
365044000522	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044000523	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044000524	RelB antitoxin; Region: RelB; cl01171
365044000525	Predicted ATPase [General function prediction only]; Region: COG5293
365044000526	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
365044000527	ParB-like partition proteins; Region: parB_part; TIGR00180
365044000528	ParB-like nuclease domain; Region: ParBc; cl02129
365044000529	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
365044000530	TrfA protein; Region: TrfA; pfam07042
365044000531	Replication initiator protein A; Region: RPA; cl02339
365044000532	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
365044000533	ParB-like nuclease domain; Region: ParBc; cl02129
365044000534	ParA-like protein; Provisional; Region: PHA02518
365044000535	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000536	P-loop; other site
365044000537	Magnesium ion binding site [ion binding]; other site
365044000538	Phage integrase protein; Region: DUF3701; pfam12482
365044000539	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000540	active site
365044000541	DNA binding site [nucleotide binding]
365044000542	Int/Topo IB signature motif; other site
365044000543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044000544	dimer interface [polypeptide binding]; other site
365044000545	phosphorylation site [posttranslational modification]
365044000546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044000547	ATP binding site [chemical binding]; other site
365044000548	Mg2+ binding site [ion binding]; other site
365044000549	G-X-G motif; other site
365044000550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044000551	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
365044000552	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
365044000553	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000554	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
365044000555	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044000556	motif II; other site
365044000557	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365044000558	Integrase core domain; Region: rve; cl01316
365044000559	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044000560	Integrase core domain; Region: rve; cl01316
365044000561	Winged helix-turn helix; Region: HTH_33; pfam13592
365044000562	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000563	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044000564	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000565	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044000566	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000567	metal-binding site [ion binding]
365044000568	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
365044000569	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000570	metal-binding site [ion binding]
365044000571	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000572	metal-binding site [ion binding]
365044000573	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
365044000574	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000575	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044000576	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
365044000577	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
365044000578	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
365044000579	active site
365044000580	dimer interface [polypeptide binding]; other site
365044000581	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
365044000582	Ligand Binding Site [chemical binding]; other site
365044000583	Molecular Tunnel; other site
365044000584	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
365044000585	putative active site [active]
365044000586	catalytic residue [active]
365044000587	phosphoglucomutase; Validated; Region: PRK07564
365044000588	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
365044000589	active site
365044000590	substrate binding site [chemical binding]; other site
365044000591	metal binding site [ion binding]; metal-binding site
365044000592	putative phosphoketolase; Provisional; Region: PRK05261
365044000593	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
365044000594	TPP-binding site; other site
365044000595	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
365044000596	XFP C-terminal domain; Region: XFP_C; pfam09363
365044000597	Acetokinase family; Region: Acetate_kinase; cl01029
365044000598	transketolase; Reviewed; Region: PRK05899
365044000599	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365044000600	TPP-binding site [chemical binding]; other site
365044000601	dimer interface [polypeptide binding]; other site
365044000602	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044000603	PYR/PP interface [polypeptide binding]; other site
365044000604	dimer interface [polypeptide binding]; other site
365044000605	TPP binding site [chemical binding]; other site
365044000606	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044000607	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
365044000608	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
365044000609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044000610	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
365044000611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
365044000612	Putative glucoamylase; Region: Glycoamylase; pfam10091
365044000613	Integrase core domain; Region: rve; cl01316
365044000614	Winged helix-turn helix; Region: HTH_29; pfam13551
365044000615	Helix-turn-helix domains; Region: HTH; cl00088
365044000616	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
365044000617	putative active site [active]
365044000618	catalytic site [active]
365044000619	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
365044000620	PLD-like domain; Region: PLDc_2; pfam13091
365044000621	putative active site [active]
365044000622	catalytic site [active]
365044000623	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
365044000624	Outer membrane efflux protein; Region: OEP; pfam02321
365044000625	Outer membrane efflux protein; Region: OEP; pfam02321
365044000626	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
365044000627	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044000628	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
365044000629	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
365044000630	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044000631	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044000632	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044000633	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
365044000634	Phospholipid methyltransferase; Region: PEMT; cl00763
365044000635	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000636	metal-binding site [ion binding]
365044000637	Short C-terminal domain; Region: SHOCT; cl01373
365044000638	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000639	metal-binding site [ion binding]
365044000640	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
365044000641	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000642	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
365044000643	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000644	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044000645	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
365044000646	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
365044000647	NAD binding site [chemical binding]; other site
365044000648	homotetramer interface [polypeptide binding]; other site
365044000649	homodimer interface [polypeptide binding]; other site
365044000650	substrate binding site [chemical binding]; other site
365044000651	active site
365044000652	Acetokinase family; Region: Acetate_kinase; cl01029
365044000653	acetate kinase; Region: ackA; TIGR00016
365044000654	Propanediol utilisation protein PduL; Region: PduL; pfam06130
365044000655	Propanediol utilisation protein PduL; Region: PduL; pfam06130
365044000656	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
365044000657	copper exporting ATPase; Provisional; Region: copA; PRK10671
365044000658	Creatinine amidohydrolase; Region: Creatininase; cl00618
365044000659	Helix-turn-helix domains; Region: HTH; cl00088
365044000660	Helix-turn-helix domains; Region: HTH; cl00088
365044000661	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044000662	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044000663	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044000664	Integrase core domain; Region: rve; cl01316
365044000665	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044000666	Domain of unknown function (DUF305); Region: DUF305; cl15795
365044000667	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
365044000668	Phospholipid methyltransferase; Region: PEMT; cl00763
365044000669	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044000670	metal-binding site [ion binding]
365044000671	LemA family; Region: LemA; cl00742
365044000672	Repair protein; Region: Repair_PSII; cl01535
365044000673	Repair protein; Region: Repair_PSII; cl01535
365044000674	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
365044000675	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044000676	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044000677	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044000678	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044000679	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000680	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000681	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000682	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044000683	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
365044000684	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044000685	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044000686	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044000687	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
365044000688	Copper resistance protein K; Region: CopK; pfam11525
365044000689	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
365044000690	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044000691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044000692	dimer interface [polypeptide binding]; other site
365044000693	phosphorylation site [posttranslational modification]
365044000694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044000695	ATP binding site [chemical binding]; other site
365044000696	Mg2+ binding site [ion binding]; other site
365044000697	G-X-G motif; other site
365044000698	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
365044000699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044000700	active site
365044000701	phosphorylation site [posttranslational modification]
365044000702	intermolecular recognition site; other site
365044000703	dimerization interface [polypeptide binding]; other site
365044000704	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044000705	DNA binding site [nucleotide binding]
365044000706	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
365044000707	Domain of unknown function (DUF305); Region: DUF305; cl15795
365044000708	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
365044000709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044000710	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
365044000711	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044000712	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044000713	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044000714	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000715	active site
365044000716	Int/Topo IB signature motif; other site
365044000717	DNA binding site [nucleotide binding]
365044000718	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
365044000719	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
365044000720	H-NS histone family; Region: Histone_HNS; pfam00816
365044000721	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
365044000722	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
365044000723	RNA/DNA binding site [nucleotide binding]; other site
365044000724	RRM dimerization site [polypeptide binding]; other site
365044000725	putative S-transferase; Provisional; Region: PRK11752
365044000726	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
365044000727	C-terminal domain interface [polypeptide binding]; other site
365044000728	GSH binding site (G-site) [chemical binding]; other site
365044000729	dimer interface [polypeptide binding]; other site
365044000730	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
365044000731	dimer interface [polypeptide binding]; other site
365044000732	N-terminal domain interface [polypeptide binding]; other site
365044000733	active site
365044000734	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044000735	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
365044000736	putative C-terminal domain interface [polypeptide binding]; other site
365044000737	putative GSH binding site (G-site) [chemical binding]; other site
365044000738	putative dimer interface [polypeptide binding]; other site
365044000739	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044000740	N-terminal domain interface [polypeptide binding]; other site
365044000741	dimer interface [polypeptide binding]; other site
365044000742	substrate binding pocket (H-site) [chemical binding]; other site
365044000743	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
365044000744	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044000745	Active Sites [active]
365044000746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044000747	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
365044000748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044000749	ATP binding site [chemical binding]; other site
365044000750	Mg2+ binding site [ion binding]; other site
365044000751	G-X-G motif; other site
365044000752	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
365044000753	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000754	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000755	Helix-turn-helix domains; Region: HTH; cl00088
365044000756	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
365044000757	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000758	Integrase core domain; Region: rve; cl01316
365044000759	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
365044000760	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
365044000761	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
365044000762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044000763	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044000764	Walker A motif; other site
365044000765	ATP binding site [chemical binding]; other site
365044000766	Walker B motif; other site
365044000767	arginine finger; other site
365044000768	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
365044000769	PIN domain; Region: PIN_Smg5-Smg6-like; cd09880
365044000770	putative active site [active]
365044000771	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000772	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000773	Family description; Region: UvrD_C_2; cl15862
365044000774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044000775	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044000776	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044000777	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
365044000778	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
365044000779	active site
365044000780	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
365044000781	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000782	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000783	AAA domain; Region: AAA_27; pfam13514
365044000784	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044000785	AAA domain; Region: AAA_25; pfam13481
365044000786	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000787	Walker A motif; other site
365044000788	ATP binding site [chemical binding]; other site
365044000789	Walker B motif; other site
365044000790	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
365044000791	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044000792	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
365044000793	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044000794	putative active site [active]
365044000795	putative metal binding site [ion binding]; other site
365044000796	Acylphosphatase; Region: Acylphosphatase; cl00551
365044000797	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
365044000798	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
365044000799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044000800	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
365044000801	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
365044000802	homodimer interface [polypeptide binding]; other site
365044000803	chemical substrate binding site [chemical binding]; other site
365044000804	oligomer interface [polypeptide binding]; other site
365044000805	metal binding site [ion binding]; metal-binding site
365044000806	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
365044000807	putative active site [active]
365044000808	Zn binding site [ion binding]; other site
365044000809	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
365044000810	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000811	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000812	Protein of unknown function (DUF433); Region: DUF433; cl01030
365044000813	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365044000814	Cation efflux family; Region: Cation_efflux; cl00316
365044000815	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353
365044000816	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
365044000817	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
365044000818	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
365044000819	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
365044000820	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
365044000821	FixH; Region: FixH; cl01254
365044000822	C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; Region: W2; cl00692
365044000823	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
365044000824	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
365044000825	nucleotide binding site/active site [active]
365044000826	HIT family signature motif; other site
365044000827	catalytic residue [active]
365044000828	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
365044000829	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
365044000830	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
365044000831	generic binding surface II; other site
365044000832	generic binding surface I; other site
365044000833	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
365044000834	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044000835	dimer interface [polypeptide binding]; other site
365044000836	ssDNA binding site [nucleotide binding]; other site
365044000837	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044000838	TfoX N-terminal domain; Region: TfoX_N; cl01167
365044000839	Cupin domain; Region: Cupin_2; cl09118
365044000840	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
365044000841	H-NS histone family; Region: Histone_HNS; pfam00816
365044000842	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
365044000843	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
365044000844	Restriction endonuclease; Region: Mrr_cat; cl00516
365044000845	Cell division inhibitor SulA; Region: SulA; cl01880
365044000846	Y-family of DNA polymerases; Region: PolY; cl12025
365044000847	DNA binding site [nucleotide binding]
365044000848	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
365044000849	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
365044000850	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
365044000851	generic binding surface II; other site
365044000852	generic binding surface I; other site
365044000853	Y-family of DNA polymerases; Region: PolY; cl12025
365044000854	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
365044000855	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044000856	active site
365044000857	substrate binding site [chemical binding]; other site
365044000858	Mg2+ binding site [ion binding]; other site
365044000859	Y-family of DNA polymerases; Region: PolY; cl12025
365044000860	DNA binding site [nucleotide binding]
365044000861	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044000862	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000863	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000864	Walker A/P-loop; other site
365044000865	ATP binding site [chemical binding]; other site
365044000866	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
365044000867	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365044000868	putative active site [active]
365044000869	putative metal-binding site [ion binding]; other site
365044000870	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
365044000871	RNA binding site [nucleotide binding]; other site
365044000872	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
365044000873	putative metal binding site [ion binding]; other site
365044000874	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
365044000875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044000876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044000877	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000878	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138
365044000879	PLD-like domain; Region: PLDc_2; pfam13091
365044000880	putative active site [active]
365044000881	catalytic site [active]
365044000882	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365044000883	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
365044000884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044000885	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
365044000886	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044000887	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044000888	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044000889	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
365044000890	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
365044000891	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
365044000892	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
365044000893	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044000894	ATP binding site [chemical binding]; other site
365044000895	putative Mg++ binding site [ion binding]; other site
365044000896	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044000897	Phage integrase protein; Region: DUF3701; pfam12482
365044000898	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044000899	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
365044000900	active site
365044000901	DNA binding site [nucleotide binding]
365044000902	Int/Topo IB signature motif; other site
365044000903	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
365044000904	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044000905	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044000906	P loop; other site
365044000907	P-loop; other site
365044000908	Nucleotide binding site [chemical binding]; other site
365044000909	Magnesium ion binding site [ion binding]; other site
365044000910	DTAP/Switch II; other site
365044000911	Switch I; other site
365044000912	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
365044000913	ParB-like nuclease domain; Region: ParBc; cl02129
365044000914	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000915	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000916	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044000917	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044000918	Initiator Replication protein; Region: Rep_3; cl03080
365044000919	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
365044000920	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044000921	active site
365044000922	Int/Topo IB signature motif; other site
365044000923	catalytic residues [active]
365044000924	DNA binding site [nucleotide binding]
365044000925	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
365044000926	Fic family protein [Function unknown]; Region: COG3177
365044000927	Fic/DOC family; Region: Fic; cl00960
365044000928	Archaeal ATPase; Region: Arch_ATPase; pfam01637
365044000929	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
365044000930	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
365044000931	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
365044000932	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
365044000933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
365044000934	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
365044000935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044000936	S-adenosylmethionine binding site [chemical binding]; other site
365044000937	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
365044000938	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044000939	active site
365044000940	ATP binding site [chemical binding]; other site
365044000941	substrate binding site [chemical binding]; other site
365044000942	activation loop (A-loop); other site
365044000943	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044000944	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
365044000945	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
365044000946	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044000947	DNA helicase IV; Provisional; Region: helD; PRK11054
365044000948	Family description; Region: UvrD_C_2; cl15862
365044000949	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365044000950	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
365044000951	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365044000952	PLD-like domain; Region: PLDc_2; pfam13091
365044000953	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044000954	putative active site [active]
365044000955	catalytic site [active]
365044000956	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
365044000957	putative homodimer interface [polypeptide binding]; other site
365044000958	putative active site [active]
365044000959	catalytic site [active]
365044000960	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
365044000961	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365044000962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044000963	NMT1-like family; Region: NMT1_2; cl15260
365044000964	amidase; Provisional; Region: PRK07486
365044000965	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
365044000966	Helix-turn-helix domains; Region: HTH; cl00088
365044000967	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
365044000968	dimerization interface [polypeptide binding]; other site
365044000969	substrate binding pocket [chemical binding]; other site
365044000970	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
365044000971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044000972	catalytic residue [active]
365044000973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044000974	NMT1-like family; Region: NMT1_2; cl15260
365044000975	amidase; Provisional; Region: PRK07486
365044000976	Amidase; Region: Amidase; cl11426
365044000977	enoyl-CoA hydratase; Provisional; Region: PRK07509
365044000978	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
365044000979	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044000980	Helix-turn-helix domains; Region: HTH; cl00088
365044000981	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044000982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044000983	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
365044000984	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
365044000985	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
365044000986	FMN-binding pocket [chemical binding]; other site
365044000987	flavin binding motif; other site
365044000988	phosphate binding motif [ion binding]; other site
365044000989	beta-alpha-beta structure motif; other site
365044000990	NAD binding pocket [chemical binding]; other site
365044000991	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044000992	catalytic loop [active]
365044000993	iron binding site [ion binding]; other site
365044000994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044000995	NMT1-like family; Region: NMT1_2; cl15260
365044000996	NMT1-like family; Region: NMT1_2; cl15260
365044000997	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
365044000998	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
365044000999	hydrophobic ligand binding site; other site
365044001000	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044001001	octamerization interface [polypeptide binding]; other site
365044001002	diferric-oxygen binding site [ion binding]; other site
365044001003	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044001004	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044001005	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
365044001006	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
365044001007	dimerization interface [polypeptide binding]; other site
365044001008	active site
365044001009	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
365044001010	YokU-like protein; Region: YokU; cl15819
365044001011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001012	non-specific DNA binding site [nucleotide binding]; other site
365044001013	salt bridge; other site
365044001014	sequence-specific DNA binding site [nucleotide binding]; other site
365044001015	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044001016	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044001017	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044001018	catalytic residues [active]
365044001019	catalytic nucleophile [active]
365044001020	Recombinase; Region: Recombinase; pfam07508
365044001021	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044001022	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044001023	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044001024	Integrase core domain; Region: rve; cl01316
365044001025	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044001026	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044001027	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001028	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001029	putative metal binding site [ion binding]; other site
365044001030	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044001031	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044001032	Transposase domain (DUF772); Region: DUF772; pfam05598
365044001033	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044001034	Transposase domain (DUF772); Region: DUF772; pfam05598
365044001035	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044001036	HTH-like domain; Region: HTH_21; pfam13276
365044001037	Integrase core domain; Region: rve; cl01316
365044001038	Helix-turn-helix domains; Region: HTH; cl00088
365044001039	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
365044001040	Integral membrane protein TerC family; Region: TerC; cl10468
365044001041	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001042	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001043	putative metal binding site [ion binding]; other site
365044001044	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001045	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001046	putative metal binding site [ion binding]; other site
365044001047	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001048	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001049	putative metal binding site [ion binding]; other site
365044001050	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044001051	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044001052	active site
365044001053	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
365044001054	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
365044001055	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
365044001056	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044001057	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001058	putative metal binding site [ion binding]; other site
365044001059	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
365044001060	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001061	putative metal binding site [ion binding]; other site
365044001062	Protein kinase domain; Region: Pkinase; pfam00069
365044001063	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044001064	substrate binding site [chemical binding]; other site
365044001065	activation loop (A-loop); other site
365044001066	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
365044001067	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
365044001068	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044001069	metal ion-dependent adhesion site (MIDAS); other site
365044001070	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
365044001071	metal ion-dependent adhesion site (MIDAS); other site
365044001072	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
365044001073	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
365044001074	putative metal binding site [ion binding]; other site
365044001075	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
365044001076	metal ion-dependent adhesion site (MIDAS); other site
365044001077	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
365044001078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
365044001079	TolB amino-terminal domain; Region: TolB_N; cl00639
365044001080	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044001081	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
365044001082	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
365044001083	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
365044001084	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044001085	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001086	AAA domain; Region: AAA_22; pfam13401
365044001087	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
365044001088	Helix-turn-helix domains; Region: HTH; cl00088
365044001089	Integrase core domain; Region: rve; cl01316
365044001090	Protein of unknown function (DUF465); Region: DUF465; cl01070
365044001091	Phage integrase protein; Region: DUF3701; pfam12482
365044001092	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
365044001093	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044001094	active site
365044001095	DNA binding site [nucleotide binding]
365044001096	Int/Topo IB signature motif; other site
365044001097	ParB-like nuclease domain; Region: ParBc; cl02129
365044001098	ParB-like partition proteins; Region: parB_part; TIGR00180
365044001099	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
365044001100	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001101	P-loop; other site
365044001102	Magnesium ion binding site [ion binding]; other site
365044001103	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001104	Initiator Replication protein; Region: Rep_3; cl03080
365044001105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001106	non-specific DNA binding site [nucleotide binding]; other site
365044001107	salt bridge; other site
365044001108	sequence-specific DNA binding site [nucleotide binding]; other site
365044001109	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044001110	ParB-like partition proteins; Region: parB_part; TIGR00180
365044001111	ParB-like nuclease domain; Region: ParBc; cl02129
365044001112	NeuB family; Region: NeuB; cl00496
365044001113	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365044001114	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044001115	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044001116	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044001117	catalytic residues [active]
365044001118	catalytic nucleophile [active]
365044001119	Recombinase; Region: Recombinase; pfam07508
365044001120	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044001121	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044001122	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044001123	Integrase core domain; Region: rve; cl01316
365044001124	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044001125	Helix-turn-helix domains; Region: HTH; cl00088
365044001126	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044001127	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044001128	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044001129	Integrase core domain; Region: rve; cl01316
365044001130	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044001131	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044001132	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044001133	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044001134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044001135	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044001136	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044001137	H-NS histone family; Region: Histone_HNS; pfam00816
365044001138	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
365044001139	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
365044001140	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044001141	Ligand Binding Site [chemical binding]; other site
365044001142	Dodecin; Region: Dodecin; cl01328
365044001143	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044001144	dimer interface [polypeptide binding]; other site
365044001145	ssDNA binding site [nucleotide binding]; other site
365044001146	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044001147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
365044001148	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044001149	Phage Tail Collar Domain; Region: Collar; pfam07484
365044001150	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044001151	Integrase core domain; Region: rve; cl01316
365044001152	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001153	Helix-turn-helix domains; Region: HTH; cl00088
365044001154	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
365044001155	Calcium binding; Region: Calci_bind_CcbP; pfam11535
365044001156	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044001157	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044001158	H-NS histone family; Region: Histone_HNS; pfam00816
365044001159	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
365044001160	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
365044001161	RNA/DNA binding site [nucleotide binding]; other site
365044001162	RRM dimerization site [polypeptide binding]; other site
365044001163	putative S-transferase; Provisional; Region: PRK11752
365044001164	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
365044001165	C-terminal domain interface [polypeptide binding]; other site
365044001166	GSH binding site (G-site) [chemical binding]; other site
365044001167	dimer interface [polypeptide binding]; other site
365044001168	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
365044001169	dimer interface [polypeptide binding]; other site
365044001170	N-terminal domain interface [polypeptide binding]; other site
365044001171	active site
365044001172	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044001173	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
365044001174	putative C-terminal domain interface [polypeptide binding]; other site
365044001175	putative GSH binding site (G-site) [chemical binding]; other site
365044001176	putative dimer interface [polypeptide binding]; other site
365044001177	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044001178	N-terminal domain interface [polypeptide binding]; other site
365044001179	dimer interface [polypeptide binding]; other site
365044001180	substrate binding pocket (H-site) [chemical binding]; other site
365044001181	Helix-turn-helix domains; Region: HTH; cl00088
365044001182	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001183	Helix-turn-helix domains; Region: HTH; cl00088
365044001184	Integrase core domain; Region: rve; cl01316
365044001185	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044001186	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001187	ABC transporter signature motif; other site
365044001188	Walker B; other site
365044001189	D-loop; other site
365044001190	H-loop/switch region; other site
365044001191	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
365044001192	threonine and homoserine efflux system; Provisional; Region: PRK10532
365044001193	EamA-like transporter family; Region: EamA; cl01037
365044001194	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
365044001195	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044001196	Putative transposase; Region: Y2_Tnp; pfam04986
365044001197	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044001198	Helix-turn-helix domains; Region: HTH; cl00088
365044001199	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044001200	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044001201	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
365044001202	putative active site [active]
365044001203	catalytic triad [active]
365044001204	putative dimer interface [polypeptide binding]; other site
365044001205	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044001206	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
365044001207	putative ligand binding site [chemical binding]; other site
365044001208	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044001209	TM-ABC transporter signature motif; other site
365044001210	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044001211	TM-ABC transporter signature motif; other site
365044001212	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044001213	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044001214	Walker A/P-loop; other site
365044001215	ATP binding site [chemical binding]; other site
365044001216	Q-loop/lid; other site
365044001217	ABC transporter signature motif; other site
365044001218	Walker B; other site
365044001219	D-loop; other site
365044001220	H-loop/switch region; other site
365044001221	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044001222	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044001223	Walker A/P-loop; other site
365044001224	ATP binding site [chemical binding]; other site
365044001225	Q-loop/lid; other site
365044001226	ABC transporter signature motif; other site
365044001227	Walker B; other site
365044001228	D-loop; other site
365044001229	H-loop/switch region; other site
365044001230	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
365044001231	Integrase core domain; Region: rve; cl01316
365044001232	Helix-turn-helix domains; Region: HTH; cl00088
365044001233	Winged helix-turn helix; Region: HTH_29; pfam13551
365044001234	Helix-turn-helix domains; Region: HTH; cl00088
365044001235	Winged helix-turn helix; Region: HTH_33; pfam13592
365044001236	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044001237	Dodecin; Region: Dodecin; cl01328
365044001238	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044001239	DNA-binding site [nucleotide binding]; DNA binding site
365044001240	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044001241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044001242	homodimer interface [polypeptide binding]; other site
365044001243	catalytic residue [active]
365044001244	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
365044001245	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
365044001246	dimer interface [polypeptide binding]; other site
365044001247	TPP-binding site [chemical binding]; other site
365044001248	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
365044001249	Helix-turn-helix domains; Region: HTH; cl00088
365044001250	Helix-turn-helix domains; Region: HTH; cl00088
365044001251	AsnC family; Region: AsnC_trans_reg; pfam01037
365044001252	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
365044001253	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044001254	oligomeric interface; other site
365044001255	putative active site [active]
365044001256	homodimer interface [polypeptide binding]; other site
365044001257	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
365044001258	Phage Tail Collar Domain; Region: Collar; pfam07484
365044001259	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
365044001260	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
365044001261	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
365044001262	Replication initiator protein A; Region: RPA; cl02339
365044001263	ParA-like protein; Provisional; Region: PHA02518
365044001264	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001265	P-loop; other site
365044001266	Magnesium ion binding site [ion binding]; other site
365044001267	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365044001268	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
365044001269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044001270	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365044001271	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
365044001272	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
365044001273	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
365044001274	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
365044001275	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
365044001276	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
365044001277	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
365044001278	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
365044001279	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044001280	ATP binding site [chemical binding]; other site
365044001281	putative Mg++ binding site [ion binding]; other site
365044001282	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
365044001283	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
365044001284	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
365044001285	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044001286	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
365044001287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001288	Walker A motif; other site
365044001289	ATP binding site [chemical binding]; other site
365044001290	Walker B motif; other site
365044001291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044001292	Integrase core domain; Region: rve; cl01316
365044001293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
365044001294	Domain of unknown function (DUF955); Region: DUF955; cl01076
365044001295	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001296	non-specific DNA binding site [nucleotide binding]; other site
365044001297	salt bridge; other site
365044001298	sequence-specific DNA binding site [nucleotide binding]; other site
365044001299	Domain of unknown function (DUF955); Region: DUF955; cl01076
365044001300	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365044001301	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044001302	catalytic residues [active]
365044001303	catalytic nucleophile [active]
365044001304	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044001305	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044001306	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044001307	Synaptic Site I dimer interface [polypeptide binding]; other site
365044001308	DNA binding site [nucleotide binding]
365044001309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001310	Walker A motif; other site
365044001311	ATP binding site [chemical binding]; other site
365044001312	Walker B motif; other site
365044001313	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
365044001314	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044001315	active site
365044001316	DNA binding site [nucleotide binding]
365044001317	Int/Topo IB signature motif; other site
365044001318	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044001319	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044001320	active site
365044001321	substrate binding site [chemical binding]; other site
365044001322	Mg2+ binding site [ion binding]; other site
365044001323	CHC2 zinc finger; Region: zf-CHC2; cl15369
365044001324	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
365044001325	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
365044001326	active site
365044001327	metal binding site [ion binding]; metal-binding site
365044001328	interdomain interaction site; other site
365044001329	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044001330	putative active site [active]
365044001331	putative NTP binding site [chemical binding]; other site
365044001332	putative nucleic acid binding site [nucleotide binding]; other site
365044001333	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044001334	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
365044001335	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044001336	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044001337	putative active site [active]
365044001338	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
365044001339	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
365044001340	putative active site [active]
365044001341	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
365044001342	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044001343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044001344	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
365044001345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044001346	cofactor binding site; other site
365044001347	DNA binding site [nucleotide binding]
365044001348	substrate interaction site [chemical binding]; other site
365044001349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044001350	Protein of unknown function DUF262; Region: DUF262; cl14890
365044001351	Predicted transcriptional regulator [Transcription]; Region: COG2932
365044001352	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365044001353	Catalytic site [active]
365044001354	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
365044001355	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001356	AAA domain; Region: AAA_31; pfam13614
365044001357	P-loop; other site
365044001358	Magnesium ion binding site [ion binding]; other site
365044001359	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
365044001360	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
365044001361	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
365044001362	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001363	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
365044001364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044001365	Replication initiator protein A; Region: RPA; cl02339
365044001366	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
365044001367	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044001368	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365044001369	catalytic residues [active]
365044001370	catalytic nucleophile [active]
365044001371	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044001372	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044001373	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044001374	Synaptic Site I dimer interface [polypeptide binding]; other site
365044001375	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365044001376	DNA-binding interface [nucleotide binding]; DNA binding site
365044001377	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001378	Walker A motif; other site
365044001379	ATP binding site [chemical binding]; other site
365044001380	Walker B motif; other site
365044001381	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
365044001382	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001383	non-specific DNA binding site [nucleotide binding]; other site
365044001384	salt bridge; other site
365044001385	sequence-specific DNA binding site [nucleotide binding]; other site
365044001386	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044001387	non-specific DNA binding site [nucleotide binding]; other site
365044001388	salt bridge; other site
365044001389	sequence-specific DNA binding site [nucleotide binding]; other site
365044001390	ParA-like protein; Provisional; Region: PHA02518
365044001391	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001392	P-loop; other site
365044001393	Magnesium ion binding site [ion binding]; other site
365044001394	MobA/MobL family; Region: MobA_MobL; pfam03389
365044001395	Domain of unknown function DUF29; Region: DUF29; pfam01724
365044001396	Replication protein C (RepC); Region: RepC; pfam06504
365044001397	AAA domain; Region: AAA_25; pfam13481
365044001398	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001399	Walker A motif; other site
365044001400	ATP binding site [chemical binding]; other site
365044001401	Walker B motif; other site
365044001402	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
365044001403	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
365044001404	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
365044001405	active site
365044001406	metal binding site [ion binding]; metal-binding site
365044001407	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
365044001408	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
365044001409	Phospholipid methyltransferase; Region: PEMT; cl00763
365044001410	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
365044001411	Septum formation topological specificity factor MinE; Region: MinE; cl00538
365044001412	cell division inhibitor MinD; Provisional; Region: PRK10818
365044001413	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
365044001414	Switch I; other site
365044001415	Switch II; other site
365044001416	septum formation inhibitor; Reviewed; Region: PRK01973
365044001417	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
365044001418	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
365044001419	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001420	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
365044001421	trimer interface [polypeptide binding]; other site
365044001422	putative Zn binding site [ion binding]; other site
365044001423	Predicted integral membrane protein [Function unknown]; Region: COG0392
365044001424	cardiolipin synthase 2; Provisional; Region: PRK11263
365044001425	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
365044001426	putative active site [active]
365044001427	catalytic site [active]
365044001428	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044001429	putative active site [active]
365044001430	catalytic site [active]
365044001431	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
365044001432	putative catalytic site [active]
365044001433	putative metal binding site [ion binding]; other site
365044001434	putative phosphate binding site [ion binding]; other site
365044001435	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044001436	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
365044001437	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
365044001438	ThiC-associated domain; Region: ThiC-associated; pfam13667
365044001439	ThiC family; Region: ThiC; cl08031
365044001440	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
365044001441	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
365044001442	thiS-thiF/thiG interaction site; other site
365044001443	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
365044001444	ThiS interaction site; other site
365044001445	putative active site [active]
365044001446	tetramer interface [polypeptide binding]; other site
365044001447	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
365044001448	active site
365044001449	thiamine phosphate binding site [chemical binding]; other site
365044001450	pyrophosphate binding site [ion binding]; other site
365044001451	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
365044001452	Transglycosylase; Region: Transgly; cl07896
365044001453	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
365044001454	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
365044001455	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
365044001456	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044001457	metal ion-dependent adhesion site (MIDAS); other site
365044001458	sensory histidine kinase CreC; Provisional; Region: PRK11100
365044001459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001460	dimer interface [polypeptide binding]; other site
365044001461	phosphorylation site [posttranslational modification]
365044001462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001463	ATP binding site [chemical binding]; other site
365044001464	Mg2+ binding site [ion binding]; other site
365044001465	G-X-G motif; other site
365044001466	DNA-binding response regulator CreB; Provisional; Region: PRK11083
365044001467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001468	active site
365044001469	phosphorylation site [posttranslational modification]
365044001470	intermolecular recognition site; other site
365044001471	dimerization interface [polypeptide binding]; other site
365044001472	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044001473	DNA binding site [nucleotide binding]
365044001474	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
365044001475	FMN binding site [chemical binding]; other site
365044001476	active site
365044001477	substrate binding site [chemical binding]; other site
365044001478	catalytic residue [active]
365044001479	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044001480	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044001481	allophanate hydrolase; Provisional; Region: PRK08186
365044001482	Amidase; Region: Amidase; cl11426
365044001483	urea carboxylase; Region: urea_carbox; TIGR02712
365044001484	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044001485	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044001486	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
365044001487	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
365044001488	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
365044001489	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044001490	carboxyltransferase (CT) interaction site; other site
365044001491	biotinylation site [posttranslational modification]; other site
365044001492	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
365044001493	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
365044001494	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
365044001495	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
365044001496	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044001497	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
365044001498	Walker A/P-loop; other site
365044001499	ATP binding site [chemical binding]; other site
365044001500	Q-loop/lid; other site
365044001501	ABC transporter signature motif; other site
365044001502	Walker B; other site
365044001503	D-loop; other site
365044001504	H-loop/switch region; other site
365044001505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044001506	dimer interface [polypeptide binding]; other site
365044001507	conserved gate region; other site
365044001508	putative PBP binding loops; other site
365044001509	ABC-ATPase subunit interface; other site
365044001510	NMT1-like family; Region: NMT1_2; cl15260
365044001511	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044001512	ykkC-yxkD element as predicted by Rfam (RF00442), score 69.07
365044001513	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
365044001514	active site
365044001515	dimer interfaces [polypeptide binding]; other site
365044001516	catalytic residues [active]
365044001517	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044001518	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044001519	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
365044001520	DctM-like transporters; Region: DctM; pfam06808
365044001521	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
365044001522	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
365044001523	Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
365044001524	ATP-binding site [chemical binding]; other site
365044001525	Gluconate-6-phosphate binding site [chemical binding]; other site
365044001526	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044001527	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044001528	DNA binding site [nucleotide binding]
365044001529	domain linker motif; other site
365044001530	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
365044001531	putative ligand binding site [chemical binding]; other site
365044001532	putative dimerization interface [polypeptide binding]; other site
365044001533	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
365044001534	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
365044001535	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
365044001536	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
365044001537	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
365044001538	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044001539	Ubiquitin-like proteins; Region: UBQ; cl00155
365044001540	charged pocket; other site
365044001541	hydrophobic patch; other site
365044001542	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
365044001543	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
365044001544	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044001545	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
365044001546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044001547	CoA-ligase; Region: Ligase_CoA; cl02894
365044001548	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044001549	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
365044001550	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044001551	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
365044001552	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
365044001553	beta-ketothiolase; Provisional; Region: PRK09051
365044001554	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044001555	dimer interface [polypeptide binding]; other site
365044001556	active site
365044001557	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
365044001558	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044001559	putative active site [active]
365044001560	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
365044001561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044001562	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
365044001563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044001564	S-adenosylmethionine binding site [chemical binding]; other site
365044001565	LysE type translocator; Region: LysE; cl00565
365044001566	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
365044001567	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001568	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
365044001569	Magnesium ion binding site [ion binding]; other site
365044001570	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044001571	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044001572	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
365044001573	ParB-like nuclease domain; Region: ParBc; cl02129
365044001574	D-lactate dehydrogenase [cytochrome]; Region: PLN02805
365044001575	FAD binding domain; Region: FAD_binding_4; pfam01565
365044001576	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
365044001577	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
365044001578	Helix-turn-helix domains; Region: HTH; cl00088
365044001579	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
365044001580	substrate binding site [chemical binding]; other site
365044001581	dimerization interface [polypeptide binding]; other site
365044001582	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
365044001583	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
365044001584	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044001585	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
365044001586	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
365044001587	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
365044001588	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001589	ATP binding site [chemical binding]; other site
365044001590	Walker A motif; other site
365044001591	Walker B motif; other site
365044001592	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044001593	Probable transposase; Region: OrfB_IS605; pfam01385
365044001594	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044001595	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044001596	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044001597	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044001598	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
365044001599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044001600	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044001601	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044001602	Walker A/P-loop; other site
365044001603	ATP binding site [chemical binding]; other site
365044001604	Q-loop/lid; other site
365044001605	ABC transporter signature motif; other site
365044001606	Walker B; other site
365044001607	D-loop; other site
365044001608	H-loop/switch region; other site
365044001609	Haemolytic domain; Region: Haemolytic; cl00506
365044001610	Uncharacterized conserved protein [Function unknown]; Region: COG3025
365044001611	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
365044001612	putative active site [active]
365044001613	putative metal binding residues [ion binding]; other site
365044001614	signature motif; other site
365044001615	putative triphosphate binding site [ion binding]; other site
365044001616	CHAD domain; Region: CHAD; cl10506
365044001617	PAS fold; Region: PAS_4; pfam08448
365044001618	PAS fold; Region: PAS_4; pfam08448
365044001619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001620	PAS fold; Region: PAS_3; pfam08447
365044001621	putative active site [active]
365044001622	heme pocket [chemical binding]; other site
365044001623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001624	dimer interface [polypeptide binding]; other site
365044001625	phosphorylation site [posttranslational modification]
365044001626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001627	ATP binding site [chemical binding]; other site
365044001628	G-X-G motif; other site
365044001629	Response regulator receiver domain; Region: Response_reg; pfam00072
365044001630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001631	active site
365044001632	phosphorylation site [posttranslational modification]
365044001633	intermolecular recognition site; other site
365044001634	dimerization interface [polypeptide binding]; other site
365044001635	Flavin Reductases; Region: FlaRed; cl00801
365044001636	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
365044001637	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044001638	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
365044001639	Helix-turn-helix domains; Region: HTH; cl00088
365044001640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044001641	dimerization interface [polypeptide binding]; other site
365044001642	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044001643	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
365044001644	putative ligand binding site [chemical binding]; other site
365044001645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044001646	sensory histidine kinase AtoS; Provisional; Region: PRK11360
365044001647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044001648	GAF domain; Region: GAF_2; pfam13185
365044001649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001650	PAS fold; Region: PAS_3; pfam08447
365044001651	putative active site [active]
365044001652	heme pocket [chemical binding]; other site
365044001653	GAF domain; Region: GAF_2; pfam13185
365044001654	GAF domain; Region: GAF; cl15785
365044001655	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044001656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001657	dimer interface [polypeptide binding]; other site
365044001658	phosphorylation site [posttranslational modification]
365044001659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001660	ATP binding site [chemical binding]; other site
365044001661	Mg2+ binding site [ion binding]; other site
365044001662	G-X-G motif; other site
365044001663	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044001664	Ligand Binding Site [chemical binding]; other site
365044001665	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001666	active site
365044001667	metal binding site [ion binding]; metal-binding site
365044001668	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001669	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
365044001670	Helix-turn-helix domains; Region: HTH; cl00088
365044001671	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
365044001672	substrate binding pocket [chemical binding]; other site
365044001673	dimerization interface [polypeptide binding]; other site
365044001674	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
365044001675	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
365044001676	active site
365044001677	substrate-binding site [chemical binding]; other site
365044001678	metal-binding site [ion binding]
365044001679	GTP binding site [chemical binding]; other site
365044001680	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044001681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001682	active site
365044001683	phosphorylation site [posttranslational modification]
365044001684	intermolecular recognition site; other site
365044001685	dimerization interface [polypeptide binding]; other site
365044001686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044001687	DNA binding residues [nucleotide binding]
365044001688	dimerization interface [polypeptide binding]; other site
365044001689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001690	dimer interface [polypeptide binding]; other site
365044001691	phosphorylation site [posttranslational modification]
365044001692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001693	ATP binding site [chemical binding]; other site
365044001694	Mg2+ binding site [ion binding]; other site
365044001695	G-X-G motif; other site
365044001696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001697	active site
365044001698	phosphorylation site [posttranslational modification]
365044001699	intermolecular recognition site; other site
365044001700	dimerization interface [polypeptide binding]; other site
365044001701	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001702	Walker A/P-loop; other site
365044001703	ATP binding site [chemical binding]; other site
365044001704	ABC transporter; Region: ABC_tran; pfam00005
365044001705	Q-loop/lid; other site
365044001706	ABC transporter signature motif; other site
365044001707	Walker B; other site
365044001708	D-loop; other site
365044001709	H-loop/switch region; other site
365044001710	MOSC domain; Region: MOSC; pfam03473
365044001711	threonine dehydratase; Provisional; Region: PRK07334
365044001712	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
365044001713	tetramer interface [polypeptide binding]; other site
365044001714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044001715	catalytic residue [active]
365044001716	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
365044001717	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
365044001718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001719	Walker A motif; other site
365044001720	ATP binding site [chemical binding]; other site
365044001721	Walker B motif; other site
365044001722	arginine finger; other site
365044001723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044001724	Walker A motif; other site
365044001725	ATP binding site [chemical binding]; other site
365044001726	Walker B motif; other site
365044001727	arginine finger; other site
365044001728	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
365044001729	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044001730	ATP binding site [chemical binding]; other site
365044001731	putative Mg++ binding site [ion binding]; other site
365044001732	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044001733	nucleotide binding region [chemical binding]; other site
365044001734	ATP-binding site [chemical binding]; other site
365044001735	RQC domain; Region: RQC; cl09632
365044001736	HRDC domain; Region: HRDC; cl02578
365044001737	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
365044001738	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
365044001739	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044001740	ligand binding site [chemical binding]; other site
365044001741	flexible hinge region; other site
365044001742	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
365044001743	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
365044001744	substrate binding pocket [chemical binding]; other site
365044001745	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
365044001746	B12 binding site [chemical binding]; other site
365044001747	cobalt ligand [ion binding]; other site
365044001748	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
365044001749	Uncharacterized conserved protein [Function unknown]; Region: COG3391
365044001750	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044001751	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
365044001752	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
365044001753	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001754	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
365044001755	Nitrogen regulatory protein P-II; Region: P-II; cl00412
365044001756	Nitrogen regulatory protein P-II; Region: P-II; smart00938
365044001757	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
365044001758	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
365044001759	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
365044001760	FAD binding domain; Region: FAD_binding_4; pfam01565
365044001761	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
365044001762	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
365044001763	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044001764	Cysteine-rich domain; Region: CCG; pfam02754
365044001765	Cysteine-rich domain; Region: CCG; pfam02754
365044001766	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044001767	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
365044001768	catalytic residues [active]
365044001769	dimer interface [polypeptide binding]; other site
365044001770	EamA-like transporter family; Region: EamA; cl01037
365044001771	lysophospholipid transporter LplT; Provisional; Region: PRK11195
365044001772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044001773	alanine racemase; Reviewed; Region: dadX; PRK03646
365044001774	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
365044001775	active site
365044001776	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044001777	substrate binding site [chemical binding]; other site
365044001778	catalytic residues [active]
365044001779	dimer interface [polypeptide binding]; other site
365044001780	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365044001781	active site
365044001782	NTP binding site [chemical binding]; other site
365044001783	metal binding triad [ion binding]; metal-binding site
365044001784	antibiotic binding site [chemical binding]; other site
365044001785	Protein of unknown function DUF86; Region: DUF86; cl01031
365044001786	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044001787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044001788	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044001789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044001790	NMT1-like family; Region: NMT1_2; cl15260
365044001791	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
365044001792	putative substrate binding pocket [chemical binding]; other site
365044001793	trimer interface [polypeptide binding]; other site
365044001794	DNA repair protein RadA; Provisional; Region: PRK11823
365044001795	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
365044001796	Walker A motif/ATP binding site; other site
365044001797	ATP binding site [chemical binding]; other site
365044001798	Walker B motif; other site
365044001799	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
365044001800	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044001801	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044001802	active site
365044001803	metal binding site [ion binding]; metal-binding site
365044001804	Integrase core domain; Region: rve; cl01316
365044001805	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044001806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044001807	Spore Coat Protein U domain; Region: SCPU; cl02253
365044001808	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
365044001809	PapC C-terminal domain; Region: PapC_C; pfam13953
365044001810	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
365044001811	Spore Coat Protein U domain; Region: SCPU; cl02253
365044001812	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
365044001813	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
365044001814	homodimer interface [polypeptide binding]; other site
365044001815	substrate-cofactor binding pocket; other site
365044001816	catalytic residue [active]
365044001817	Zinc-finger domain; Region: zf-CHCC; cl01821
365044001818	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
365044001819	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
365044001820	putative active site [active]
365044001821	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044001822	dimerization interface [polypeptide binding]; other site
365044001823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001824	dimer interface [polypeptide binding]; other site
365044001825	phosphorylation site [posttranslational modification]
365044001826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001827	ATP binding site [chemical binding]; other site
365044001828	G-X-G motif; other site
365044001829	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044001830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044001831	active site
365044001832	phosphorylation site [posttranslational modification]
365044001833	intermolecular recognition site; other site
365044001834	dimerization interface [polypeptide binding]; other site
365044001835	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044001836	DNA binding site [nucleotide binding]
365044001837	AmpG-like permease; Region: 2A0125; TIGR00901
365044001838	muropeptide transporter; Validated; Region: ampG; PRK11010
365044001839	Peptidase family M48; Region: Peptidase_M48; cl12018
365044001840	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044001841	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
365044001842	NAD(P) binding site [chemical binding]; other site
365044001843	catalytic residues [active]
365044001844	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
365044001845	FMN binding site [chemical binding]; other site
365044001846	active site
365044001847	substrate binding site [chemical binding]; other site
365044001848	catalytic residue [active]
365044001849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044001850	Helix-turn-helix domains; Region: HTH; cl00088
365044001851	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
365044001852	ATP binding site [chemical binding]; other site
365044001853	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044001854	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
365044001855	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044001856	Walker A/P-loop; other site
365044001857	ATP binding site [chemical binding]; other site
365044001858	Q-loop/lid; other site
365044001859	ABC transporter signature motif; other site
365044001860	Walker B; other site
365044001861	D-loop; other site
365044001862	H-loop/switch region; other site
365044001863	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044001864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044001865	PAS domain S-box; Region: sensory_box; TIGR00229
365044001866	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
365044001867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044001868	putative active site [active]
365044001869	heme pocket [chemical binding]; other site
365044001870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044001871	dimer interface [polypeptide binding]; other site
365044001872	phosphorylation site [posttranslational modification]
365044001873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044001874	ATP binding site [chemical binding]; other site
365044001875	Mg2+ binding site [ion binding]; other site
365044001876	G-X-G motif; other site
365044001877	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
365044001878	putative active site [active]
365044001879	putative catalytic site [active]
365044001880	putative DNA binding site [nucleotide binding]; other site
365044001881	putative phosphate binding site [ion binding]; other site
365044001882	metal binding site A [ion binding]; metal-binding site
365044001883	putative AP binding site [nucleotide binding]; other site
365044001884	putative metal binding site B [ion binding]; other site
365044001885	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044001886	active site
365044001887	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
365044001888	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
365044001889	GatB domain; Region: GatB_Yqey; cl11497
365044001890	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
365044001891	Amidase; Region: Amidase; cl11426
365044001892	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
365044001893	rod shape-determining protein MreB; Provisional; Region: PRK13927
365044001894	Cell division protein FtsA; Region: FtsA; cl11496
365044001895	rod shape-determining protein MreC; Provisional; Region: PRK13922
365044001896	rod shape-determining protein MreC; Region: MreC; pfam04085
365044001897	rod shape-determining protein MreD; Region: MreD; cl01087
365044001898	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
365044001899	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365044001900	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044001901	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
365044001902	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
365044001903	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
365044001904	choline dehydrogenase; Validated; Region: PRK02106
365044001905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044001906	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
365044001907	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044001908	Helix-turn-helix domains; Region: HTH; cl00088
365044001909	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044001910	dimerization interface [polypeptide binding]; other site
365044001911	Permease; Region: Permease; cl00510
365044001912	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
365044001913	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
365044001914	Walker A/P-loop; other site
365044001915	ATP binding site [chemical binding]; other site
365044001916	Q-loop/lid; other site
365044001917	ABC transporter signature motif; other site
365044001918	Walker B; other site
365044001919	D-loop; other site
365044001920	H-loop/switch region; other site
365044001921	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
365044001922	mce related protein; Region: MCE; pfam02470
365044001923	MarC family integral membrane protein; Region: MarC; cl00919
365044001924	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
365044001925	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
365044001926	putative catalytic residue [active]
365044001927	Dienelactone hydrolase family; Region: DLH; pfam01738
365044001928	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044001929	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
365044001930	Protein of unknown function DUF72; Region: DUF72; cl00777
365044001931	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
365044001932	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
365044001933	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
365044001934	dimer interface [polypeptide binding]; other site
365044001935	allosteric magnesium binding site [ion binding]; other site
365044001936	active site
365044001937	aspartate-rich active site metal binding site; other site
365044001938	Schiff base residues; other site
365044001939	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
365044001940	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
365044001941	dimer interface [polypeptide binding]; other site
365044001942	[2Fe-2S] cluster binding site [ion binding]; other site
365044001943	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
365044001944	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
365044001945	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044001946	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
365044001947	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
365044001948	S17 interaction site [polypeptide binding]; other site
365044001949	S8 interaction site; other site
365044001950	16S rRNA interaction site [nucleotide binding]; other site
365044001951	streptomycin interaction site [chemical binding]; other site
365044001952	23S rRNA interaction site [nucleotide binding]; other site
365044001953	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
365044001954	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
365044001955	elongation factor G; Reviewed; Region: PRK00007
365044001956	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
365044001957	G1 box; other site
365044001958	putative GEF interaction site [polypeptide binding]; other site
365044001959	GTP/Mg2+ binding site [chemical binding]; other site
365044001960	Switch I region; other site
365044001961	G2 box; other site
365044001962	G3 box; other site
365044001963	Switch II region; other site
365044001964	G4 box; other site
365044001965	G5 box; other site
365044001966	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
365044001967	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
365044001968	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
365044001969	elongation factor Tu; Reviewed; Region: PRK00049
365044001970	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
365044001971	G1 box; other site
365044001972	GEF interaction site [polypeptide binding]; other site
365044001973	GTP/Mg2+ binding site [chemical binding]; other site
365044001974	Switch I region; other site
365044001975	G2 box; other site
365044001976	G3 box; other site
365044001977	Switch II region; other site
365044001978	G4 box; other site
365044001979	G5 box; other site
365044001980	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
365044001981	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
365044001982	Antibiotic Binding Site [chemical binding]; other site
365044001983	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
365044001984	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
365044001985	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
365044001986	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
365044001987	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
365044001988	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
365044001989	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
365044001990	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
365044001991	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
365044001992	putative translocon binding site; other site
365044001993	protein-rRNA interface [nucleotide binding]; other site
365044001994	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
365044001995	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
365044001996	G-X-X-G motif; other site
365044001997	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
365044001998	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
365044001999	23S rRNA interface [nucleotide binding]; other site
365044002000	5S rRNA interface [nucleotide binding]; other site
365044002001	putative antibiotic binding site [chemical binding]; other site
365044002002	L25 interface [polypeptide binding]; other site
365044002003	L27 interface [polypeptide binding]; other site
365044002004	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
365044002005	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
365044002006	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
365044002007	catalytic triad [active]
365044002008	dimer interface [polypeptide binding]; other site
365044002009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044002010	Coenzyme A binding pocket [chemical binding]; other site
365044002011	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044002012	Cytochrome C'; Region: Cytochrom_C_2; cl01610
365044002013	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044002014	catalytic residues [active]
365044002015	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
365044002016	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
365044002017	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365044002018	homodimer interface [polypeptide binding]; other site
365044002019	substrate-cofactor binding pocket; other site
365044002020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002021	catalytic residue [active]
365044002022	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044002023	Protein of unknown function (DUF445); Region: DUF445; pfam04286
365044002024	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044002025	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044002026	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044002027	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044002028	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044002029	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044002030	DNA binding site [nucleotide binding]
365044002031	domain linker motif; other site
365044002032	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
365044002033	ligand binding site [chemical binding]; other site
365044002034	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044002035	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044002036	DNA binding site [nucleotide binding]
365044002037	domain linker motif; other site
365044002038	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
365044002039	putative dimerization interface [polypeptide binding]; other site
365044002040	putative ligand binding site [chemical binding]; other site
365044002041	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044002042	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044002043	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044002044	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
365044002045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044002046	putative PBP binding loops; other site
365044002047	ABC-ATPase subunit interface; other site
365044002048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044002049	dimer interface [polypeptide binding]; other site
365044002050	conserved gate region; other site
365044002051	putative PBP binding loops; other site
365044002052	ABC-ATPase subunit interface; other site
365044002053	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
365044002054	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
365044002055	Walker A/P-loop; other site
365044002056	ATP binding site [chemical binding]; other site
365044002057	Q-loop/lid; other site
365044002058	ABC transporter signature motif; other site
365044002059	Walker B; other site
365044002060	D-loop; other site
365044002061	H-loop/switch region; other site
365044002062	TOBE domain; Region: TOBE_2; cl01440
365044002063	sucrose phosphorylase; Provisional; Region: PRK13840
365044002064	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
365044002065	active site
365044002066	homodimer interface [polypeptide binding]; other site
365044002067	catalytic site [active]
365044002068	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044002069	Ligand Binding Site [chemical binding]; other site
365044002070	Dodecin; Region: Dodecin; cl01328
365044002071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044002072	putative substrate translocation pore; other site
365044002073	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
365044002074	active pocket/dimerization site; other site
365044002075	active site
365044002076	phosphorylation site [posttranslational modification]
365044002077	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
365044002078	dimerization domain swap beta strand [polypeptide binding]; other site
365044002079	regulatory protein interface [polypeptide binding]; other site
365044002080	active site
365044002081	regulatory phosphorylation site [posttranslational modification]; other site
365044002082	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
365044002083	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
365044002084	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
365044002085	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044002086	EamA-like transporter family; Region: EamA; cl01037
365044002087	aromatic amino acid exporter; Provisional; Region: PRK11689
365044002088	lipoyl synthase; Provisional; Region: PRK05481
365044002089	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044002090	FeS/SAM binding site; other site
365044002091	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
365044002092	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
365044002093	Protein of unknown function (DUF493); Region: DUF493; cl01102
365044002094	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
365044002095	homodimer interface [polypeptide binding]; other site
365044002096	substrate-cofactor binding pocket; other site
365044002097	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002098	catalytic residue [active]
365044002099	ATP synthase I chain; Region: ATP_synt_I; cl09170
365044002100	ATP synthase A chain; Region: ATP-synt_A; cl00413
365044002101	ATP synthase subunit C; Region: ATP-synt_C; cl00466
365044002102	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
365044002103	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
365044002104	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
365044002105	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
365044002106	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
365044002107	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
365044002108	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
365044002109	beta subunit interaction interface [polypeptide binding]; other site
365044002110	Walker A motif; other site
365044002111	ATP binding site [chemical binding]; other site
365044002112	Walker B motif; other site
365044002113	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044002114	ATP synthase; Region: ATP-synt; cl00365
365044002115	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
365044002116	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
365044002117	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
365044002118	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
365044002119	alpha subunit interaction interface [polypeptide binding]; other site
365044002120	Walker A motif; other site
365044002121	ATP binding site [chemical binding]; other site
365044002122	Walker B motif; other site
365044002123	inhibitor binding site; inhibition site
365044002124	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044002125	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
365044002126	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
365044002127	Repair protein; Region: Repair_PSII; cl01535
365044002128	Repair protein; Region: Repair_PSII; cl01535
365044002129	LemA family; Region: LemA; cl00742
365044002130	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044002131	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
365044002132	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
365044002133	Cytochrome c; Region: Cytochrom_C; cl11414
365044002134	Cytochrome c; Region: Cytochrom_C; cl11414
365044002135	High potential iron-sulfur protein; Region: HIPIP; pfam01355
365044002136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044002137	NMT1-like family; Region: NMT1_2; cl15260
365044002138	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044002139	AMP-binding enzyme; Region: AMP-binding; cl15778
365044002140	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
365044002141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044002142	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
365044002143	putative substrate translocation pore; other site
365044002144	Predicted methyltransferases [General function prediction only]; Region: COG0313
365044002145	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044002146	Restriction endonuclease; Region: Mrr_cat; cl00516
365044002147	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
365044002148	dimer interface [polypeptide binding]; other site
365044002149	active site
365044002150	outer membrane lipoprotein; Provisional; Region: PRK11023
365044002151	BON domain; Region: BON; cl02771
365044002152	BON domain; Region: BON; cl02771
365044002153	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
365044002154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044002155	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
365044002156	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044002157	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044002158	ligand binding site [chemical binding]; other site
365044002159	flexible hinge region; other site
365044002160	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
365044002161	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
365044002162	Walker A motif; other site
365044002163	ATP binding site [chemical binding]; other site
365044002164	Walker B motif; other site
365044002165	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044002166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044002167	Probable transposase; Region: OrfB_IS605; pfam01385
365044002168	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044002169	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
365044002170	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044002171	catalytic residue [active]
365044002172	putative diguanylate cyclase; Provisional; Region: PRK09776
365044002173	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044002174	PAS fold; Region: PAS_4; pfam08448
365044002175	PAS domain; Region: PAS_9; pfam13426
365044002176	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002177	putative active site [active]
365044002178	heme pocket [chemical binding]; other site
365044002179	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
365044002180	metal binding site [ion binding]; metal-binding site
365044002181	active site
365044002182	I-site; other site
365044002183	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
365044002184	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
365044002185	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
365044002186	DXD motif; other site
365044002187	Predicted acyltransferase [General function prediction only]; Region: COG4801
365044002188	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
365044002189	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312
365044002190	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
365044002191	LrgB-like family; Region: LrgB; cl00596
365044002192	LrgA family; Region: LrgA; cl00608
365044002193	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
365044002194	FAD binding domain; Region: FAD_binding_4; pfam01565
365044002195	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
365044002196	putative active site [active]
365044002197	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
365044002198	Helix-turn-helix domains; Region: HTH; cl00088
365044002199	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
365044002200	dimerization interface [polypeptide binding]; other site
365044002201	substrate binding pocket [chemical binding]; other site
365044002202	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
365044002203	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
365044002204	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
365044002205	putative active site [active]
365044002206	putative substrate binding site [chemical binding]; other site
365044002207	putative cosubstrate binding site; other site
365044002208	catalytic site [active]
365044002209	Protein of unknown function, DUF399; Region: DUF399; cl01139
365044002210	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044002211	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044002212	putative ligand binding site [chemical binding]; other site
365044002213	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
365044002214	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
365044002215	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044002216	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044002217	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
365044002218	putative active site [active]
365044002219	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
365044002220	FIST N domain; Region: FIST; cl10701
365044002221	FIST C domain; Region: FIST_C; pfam10442
365044002222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044002223	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
365044002224	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044002225	putative acyl-acceptor binding pocket; other site
365044002226	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
365044002227	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
365044002228	yiaA/B two helix domain; Region: YiaAB; cl01759
365044002229	Double zinc ribbon; Region: DZR; pfam12773
365044002230	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
365044002231	GtrA-like protein; Region: GtrA; cl00971
365044002232	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
365044002233	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365044002234	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
365044002235	putative active site [active]
365044002236	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
365044002237	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
365044002238	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
365044002239	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
365044002240	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
365044002241	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
365044002242	generic binding surface II; other site
365044002243	ssDNA binding site; other site
365044002244	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044002245	putative Mg++ binding site [ion binding]; other site
365044002246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044002247	nucleotide binding region [chemical binding]; other site
365044002248	ATP-binding site [chemical binding]; other site
365044002249	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
365044002250	Helix-turn-helix domains; Region: HTH; cl00088
365044002251	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
365044002252	dimerization interface [polypeptide binding]; other site
365044002253	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
365044002254	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
365044002255	dimerization interface [polypeptide binding]; other site
365044002256	DPS ferroxidase diiron center [ion binding]; other site
365044002257	ion pore; other site
365044002258	UbiA prenyltransferase family; Region: UbiA; cl00337
365044002259	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
365044002260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044002261	glycerol kinase; Provisional; Region: glpK; PRK00047
365044002262	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
365044002263	N- and C-terminal domain interface [polypeptide binding]; other site
365044002264	active site
365044002265	MgATP binding site [chemical binding]; other site
365044002266	catalytic site [active]
365044002267	metal binding site [ion binding]; metal-binding site
365044002268	glycerol binding site [chemical binding]; other site
365044002269	homotetramer interface [polypeptide binding]; other site
365044002270	homodimer interface [polypeptide binding]; other site
365044002271	FBP binding site [chemical binding]; other site
365044002272	protein IIAGlc interface [polypeptide binding]; other site
365044002273	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
365044002274	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044002275	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
365044002276	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
365044002277	KOW motif; Region: KOW; cl00354
365044002278	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
365044002279	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
365044002280	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
365044002281	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
365044002282	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
365044002283	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
365044002284	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
365044002285	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
365044002286	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
365044002287	5S rRNA interface [nucleotide binding]; other site
365044002288	23S rRNA interface [nucleotide binding]; other site
365044002289	L5 interface [polypeptide binding]; other site
365044002290	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
365044002291	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
365044002292	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
365044002293	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
365044002294	23S rRNA binding site [nucleotide binding]; other site
365044002295	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
365044002296	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
365044002297	SecY translocase; Region: SecY; pfam00344
365044002298	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
365044002299	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
365044002300	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
365044002301	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
365044002302	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
365044002303	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
365044002304	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044002305	RNA binding surface [nucleotide binding]; other site
365044002306	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
365044002307	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
365044002308	alphaNTD homodimer interface [polypeptide binding]; other site
365044002309	alphaNTD - beta interaction site [polypeptide binding]; other site
365044002310	alphaNTD - beta' interaction site [polypeptide binding]; other site
365044002311	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
365044002312	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
365044002313	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044002314	Integrase core domain; Region: rve; cl01316
365044002315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044002316	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
365044002317	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
365044002318	dimerization interface [polypeptide binding]; other site
365044002319	substrate binding site [chemical binding]; other site
365044002320	active site
365044002321	calcium binding site [ion binding]; other site
365044002322	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
365044002323	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044002324	Family description; Region: UvrD_C_2; cl15862
365044002325	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
365044002326	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
365044002327	metal binding site [ion binding]; metal-binding site
365044002328	putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590
365044002329	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
365044002330	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
365044002331	active site
365044002332	metal binding site [ion binding]; metal-binding site
365044002333	dimer interface [polypeptide binding]; other site
365044002334	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
365044002335	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
365044002336	active site
365044002337	catalytic site [active]
365044002338	tetramer interface [polypeptide binding]; other site
365044002339	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
365044002340	active site
365044002341	homotetramer interface [polypeptide binding]; other site
365044002342	Protein of unknown function (DUF989); Region: DUF989; pfam06181
365044002343	Predicted membrane protein [Function unknown]; Region: COG3748
365044002344	Cytochrome c; Region: Cytochrom_C; cl11414
365044002345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002346	Walker A motif; other site
365044002347	ATP binding site [chemical binding]; other site
365044002348	Walker B motif; other site
365044002349	arginine finger; other site
365044002350	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002351	PAS fold; Region: PAS_3; pfam08447
365044002352	putative active site [active]
365044002353	heme pocket [chemical binding]; other site
365044002354	PAS fold; Region: PAS_3; pfam08447
365044002355	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
365044002356	PAS fold; Region: PAS_4; pfam08448
365044002357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044002358	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044002359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044002360	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002361	putative active site [active]
365044002362	heme pocket [chemical binding]; other site
365044002363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002364	dimer interface [polypeptide binding]; other site
365044002365	phosphorylation site [posttranslational modification]
365044002366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002367	ATP binding site [chemical binding]; other site
365044002368	Mg2+ binding site [ion binding]; other site
365044002369	G-X-G motif; other site
365044002370	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365044002371	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
365044002372	primosome assembly protein PriA; Validated; Region: PRK05580
365044002373	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044002374	ATP binding site [chemical binding]; other site
365044002375	putative Mg++ binding site [ion binding]; other site
365044002376	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
365044002377	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
365044002378	substrate binding site [chemical binding]; other site
365044002379	active site
365044002380	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
365044002381	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
365044002382	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044002383	Walker A/P-loop; other site
365044002384	ATP binding site [chemical binding]; other site
365044002385	Q-loop/lid; other site
365044002386	ABC transporter signature motif; other site
365044002387	Walker B; other site
365044002388	D-loop; other site
365044002389	H-loop/switch region; other site
365044002390	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
365044002391	active site
365044002392	catalytic residues [active]
365044002393	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
365044002394	G1 box; other site
365044002395	GTP/Mg2+ binding site [chemical binding]; other site
365044002396	G2 box; other site
365044002397	Switch I region; other site
365044002398	G3 box; other site
365044002399	Switch II region; other site
365044002400	G4 box; other site
365044002401	G5 box; other site
365044002402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044002403	S-adenosylmethionine binding site [chemical binding]; other site
365044002404	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
365044002405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044002406	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
365044002407	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
365044002408	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
365044002409	DsbD alpha interface [polypeptide binding]; other site
365044002410	catalytic residues [active]
365044002411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044002412	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
365044002413	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
365044002414	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044002415	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
365044002416	Helix-turn-helix domains; Region: HTH; cl00088
365044002417	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044002418	putative active site [active]
365044002419	putative NTP binding site [chemical binding]; other site
365044002420	putative nucleic acid binding site [nucleotide binding]; other site
365044002421	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044002422	salt bridge; other site
365044002423	non-specific DNA binding site [nucleotide binding]; other site
365044002424	sequence-specific DNA binding site [nucleotide binding]; other site
365044002425	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
365044002426	B12 binding site [chemical binding]; other site
365044002427	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
365044002428	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044002429	FeS/SAM binding site; other site
365044002430	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
365044002431	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
365044002432	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
365044002433	ring oligomerisation interface [polypeptide binding]; other site
365044002434	ATP/Mg binding site [chemical binding]; other site
365044002435	stacking interactions; other site
365044002436	hinge regions; other site
365044002437	Protein required for attachment to host cells; Region: Host_attach; cl02398
365044002438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044002439	Ligand Binding Site [chemical binding]; other site
365044002440	FtsH Extracellular; Region: FtsH_ext; pfam06480
365044002441	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
365044002442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002443	Walker A motif; other site
365044002444	ATP binding site [chemical binding]; other site
365044002445	Walker B motif; other site
365044002446	arginine finger; other site
365044002447	Peptidase family M41; Region: Peptidase_M41; pfam01434
365044002448	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
365044002449	Creatinine amidohydrolase; Region: Creatininase; cl00618
365044002450	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
365044002451	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044002452	catalytic core [active]
365044002453	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
365044002454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002455	dimer interface [polypeptide binding]; other site
365044002456	phosphorylation site [posttranslational modification]
365044002457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002458	ATP binding site [chemical binding]; other site
365044002459	Mg2+ binding site [ion binding]; other site
365044002460	G-X-G motif; other site
365044002461	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002463	active site
365044002464	phosphorylation site [posttranslational modification]
365044002465	intermolecular recognition site; other site
365044002466	dimerization interface [polypeptide binding]; other site
365044002467	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044002468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002469	active site
365044002470	phosphorylation site [posttranslational modification]
365044002471	intermolecular recognition site; other site
365044002472	dimerization interface [polypeptide binding]; other site
365044002473	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
365044002474	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
365044002475	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044002476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002477	homodimer interface [polypeptide binding]; other site
365044002478	catalytic residue [active]
365044002479	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044002480	EamA-like transporter family; Region: EamA; cl01037
365044002481	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044002482	DNA-binding site [nucleotide binding]; DNA binding site
365044002483	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044002484	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044002485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002486	homodimer interface [polypeptide binding]; other site
365044002487	catalytic residue [active]
365044002488	Fibronectin type III-like domain; Region: Fn3-like; cl15273
365044002489	Fibronectin type III-like domain; Region: Fn3-like; cl15273
365044002490	Calx-beta domain; Region: Calx-beta; cl02522
365044002491	Integrase core domain; Region: rve; cl01316
365044002492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044002493	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044002494	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
365044002495	PLD-like domain; Region: PLDc_2; pfam13091
365044002496	putative active site [active]
365044002497	catalytic site [active]
365044002498	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
365044002499	PLD-like domain; Region: PLDc_2; pfam13091
365044002500	putative active site [active]
365044002501	catalytic site [active]
365044002502	ABC transporter ATPase component; Reviewed; Region: PRK11147
365044002503	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
365044002504	Walker A/P-loop; other site
365044002505	ATP binding site [chemical binding]; other site
365044002506	Q-loop/lid; other site
365044002507	ABC transporter signature motif; other site
365044002508	Walker B; other site
365044002509	D-loop; other site
365044002510	H-loop/switch region; other site
365044002511	ABC transporter; Region: ABC_tran_2; pfam12848
365044002512	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
365044002513	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
365044002514	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044002515	catalytic residues [active]
365044002516	catalytic nucleophile [active]
365044002517	Recombinase; Region: Recombinase; pfam07508
365044002518	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044002519	Integrase core domain; Region: rve; cl01316
365044002520	Helix-turn-helix domains; Region: HTH; cl00088
365044002521	Winged helix-turn helix; Region: HTH_29; pfam13551
365044002522	Winged helix-turn helix; Region: HTH_33; pfam13592
365044002523	Integrase core domain; Region: rve; cl01316
365044002524	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044002525	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044002526	Mediator complex subunit 23; Region: Med23; pfam11573
365044002527	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044002528	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044002529	Integrase core domain; Region: rve; cl01316
365044002530	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044002531	Helix-turn-helix domains; Region: HTH; cl00088
365044002532	Transposase domain (DUF772); Region: DUF772; pfam05598
365044002533	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044002534	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044002535	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044002536	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044002537	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044002538	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044002539	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044002540	HTH-like domain; Region: HTH_21; pfam13276
365044002541	Integrase core domain; Region: rve; cl01316
365044002542	Integrase core domain; Region: rve_3; cl15866
365044002543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
365044002544	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044002545	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
365044002546	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
365044002547	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
365044002548	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
365044002549	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002551	active site
365044002552	phosphorylation site [posttranslational modification]
365044002553	intermolecular recognition site; other site
365044002554	dimerization interface [polypeptide binding]; other site
365044002555	cyclase homology domain; Region: CHD; cd07302
365044002556	nucleotidyl binding site; other site
365044002557	metal binding site [ion binding]; metal-binding site
365044002558	dimer interface [polypeptide binding]; other site
365044002559	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
365044002560	Cache domain; Region: Cache_1; pfam02743
365044002561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002562	dimer interface [polypeptide binding]; other site
365044002563	phosphorylation site [posttranslational modification]
365044002564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002565	ATP binding site [chemical binding]; other site
365044002566	Mg2+ binding site [ion binding]; other site
365044002567	G-X-G motif; other site
365044002568	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002570	active site
365044002571	phosphorylation site [posttranslational modification]
365044002572	intermolecular recognition site; other site
365044002573	dimerization interface [polypeptide binding]; other site
365044002574	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002576	active site
365044002577	phosphorylation site [posttranslational modification]
365044002578	intermolecular recognition site; other site
365044002579	dimerization interface [polypeptide binding]; other site
365044002580	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044002581	putative binding surface; other site
365044002582	active site
365044002583	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044002584	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
365044002585	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365044002586	Transporter associated domain; Region: CorC_HlyC; cl08393
365044002587	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
365044002588	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
365044002589	putative active site [active]
365044002590	catalytic triad [active]
365044002591	putative dimer interface [polypeptide binding]; other site
365044002592	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044002593	Helix-turn-helix domains; Region: HTH; cl00088
365044002594	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044002595	dimerization interface [polypeptide binding]; other site
365044002596	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
365044002597	homodimer interface [polypeptide binding]; other site
365044002598	active site
365044002599	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
365044002600	dimer interface [polypeptide binding]; other site
365044002601	motif 1; other site
365044002602	active site
365044002603	motif 2; other site
365044002604	motif 3; other site
365044002605	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
365044002606	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
365044002607	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044002608	active site
365044002609	motif I; other site
365044002610	motif II; other site
365044002611	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
365044002612	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044002613	putative acyl-acceptor binding pocket; other site
365044002614	Protein of unknown function DUF45; Region: DUF45; cl00636
365044002615	Response regulator receiver domain; Region: Response_reg; pfam00072
365044002616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002617	active site
365044002618	phosphorylation site [posttranslational modification]
365044002619	intermolecular recognition site; other site
365044002620	dimerization interface [polypeptide binding]; other site
365044002621	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
365044002622	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044002623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002624	PAS fold; Region: PAS_3; pfam08447
365044002625	putative active site [active]
365044002626	heme pocket [chemical binding]; other site
365044002627	PAS domain S-box; Region: sensory_box; TIGR00229
365044002628	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044002629	GAF domain; Region: GAF_2; pfam13185
365044002630	GAF domain; Region: GAF; cl15785
365044002631	PAS domain S-box; Region: sensory_box; TIGR00229
365044002632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044002633	putative active site [active]
365044002634	heme pocket [chemical binding]; other site
365044002635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044002636	dimer interface [polypeptide binding]; other site
365044002637	phosphorylation site [posttranslational modification]
365044002638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002639	ATP binding site [chemical binding]; other site
365044002640	Mg2+ binding site [ion binding]; other site
365044002641	G-X-G motif; other site
365044002642	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044002643	DNA binding residues [nucleotide binding]
365044002644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044002645	active site
365044002646	phosphorylation site [posttranslational modification]
365044002647	intermolecular recognition site; other site
365044002648	dimerization interface [polypeptide binding]; other site
365044002649	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
365044002650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044002651	sensory histidine kinase AtoS; Provisional; Region: PRK11360
365044002652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
365044002653	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044002654	ATP binding site [chemical binding]; other site
365044002655	Mg2+ binding site [ion binding]; other site
365044002656	G-X-G motif; other site
365044002657	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
365044002658	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
365044002659	DNA binding residues [nucleotide binding]
365044002660	putative dimer interface [polypeptide binding]; other site
365044002661	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044002662	CoenzymeA binding site [chemical binding]; other site
365044002663	subunit interaction site [polypeptide binding]; other site
365044002664	PHB binding site; other site
365044002665	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
365044002666	isovaleryl-CoA dehydrogenase; Region: PLN02519
365044002667	substrate binding site [chemical binding]; other site
365044002668	FAD binding site [chemical binding]; other site
365044002669	catalytic base [active]
365044002670	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
365044002671	active site clefts [active]
365044002672	zinc binding site [ion binding]; other site
365044002673	dimer interface [polypeptide binding]; other site
365044002674	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891
365044002675	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
365044002676	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
365044002677	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044002678	dimer interface [polypeptide binding]; other site
365044002679	active site
365044002680	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044002681	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044002682	active site
365044002683	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
365044002684	active site
365044002685	catalytic residue [active]
365044002686	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
365044002687	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044002688	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044002689	catalytic residue [active]
365044002690	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
365044002691	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
365044002692	hypothetical protein; Provisional; Region: PRK01842
365044002693	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
365044002694	Ion channel; Region: Ion_trans_2; cl11596
365044002695	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
365044002696	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044002697	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044002698	AMP-binding domain protein; Validated; Region: PRK08315
365044002699	AMP-binding enzyme; Region: AMP-binding; cl15778
365044002700	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044002701	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
365044002702	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044002703	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
365044002704	DinB superfamily; Region: DinB_2; pfam12867
365044002705	enoyl-CoA hydratase; Provisional; Region: PRK05995
365044002706	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044002707	substrate binding site [chemical binding]; other site
365044002708	oxyanion hole (OAH) forming residues; other site
365044002709	trimer interface [polypeptide binding]; other site
365044002710	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
365044002711	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
365044002712	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044002713	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044002714	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
365044002715	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
365044002716	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044002717	carboxyltransferase (CT) interaction site; other site
365044002718	biotinylation site [posttranslational modification]; other site
365044002719	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
365044002720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044002721	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044002722	active site
365044002723	catalytic residues [active]
365044002724	metal binding site [ion binding]; metal-binding site
365044002725	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
365044002726	putative deacylase active site [active]
365044002727	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
365044002728	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
365044002729	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
365044002730	putative catalytic residue [active]
365044002731	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
365044002732	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044002733	ligand binding site [chemical binding]; other site
365044002734	flexible hinge region; other site
365044002735	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
365044002736	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044002737	metal binding triad; other site
365044002738	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365044002739	active site
365044002740	catalytic site [active]
365044002741	substrate binding site [chemical binding]; other site
365044002742	BON domain; Region: BON; cl02771
365044002743	Protein of unknown function, DUF485; Region: DUF485; cl01231
365044002744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044002745	putative substrate translocation pore; other site
365044002746	metabolite-proton symporter; Region: 2A0106; TIGR00883
365044002747	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044002748	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044002749	putative ligand binding site [chemical binding]; other site
365044002750	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
365044002751	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044002752	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044002753	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044002754	Walker A/P-loop; other site
365044002755	ATP binding site [chemical binding]; other site
365044002756	Q-loop/lid; other site
365044002757	ABC transporter signature motif; other site
365044002758	Walker B; other site
365044002759	D-loop; other site
365044002760	H-loop/switch region; other site
365044002761	excinuclease ABC, A subunit; Region: uvra; TIGR00630
365044002762	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044002763	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
365044002764	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044002765	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
365044002766	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
365044002767	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
365044002768	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
365044002769	oligomerization interface [polypeptide binding]; other site
365044002770	active site
365044002771	NAD+ binding site [chemical binding]; other site
365044002772	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
365044002773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044002774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044002775	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
365044002776	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
365044002777	FAD binding site [chemical binding]; other site
365044002778	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
365044002779	Predicted transcriptional regulators [Transcription]; Region: COG1510
365044002780	Helix-turn-helix domains; Region: HTH; cl00088
365044002781	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
365044002782	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
365044002783	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
365044002784	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
365044002785	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
365044002786	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
365044002787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002788	Walker A motif; other site
365044002789	ATP binding site [chemical binding]; other site
365044002790	Walker B motif; other site
365044002791	arginine finger; other site
365044002792	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
365044002793	hypothetical protein; Reviewed; Region: PRK09588
365044002794	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
365044002795	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288
365044002796	putative active site [active]
365044002797	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
365044002798	23S rRNA interface [nucleotide binding]; other site
365044002799	L3 interface [polypeptide binding]; other site
365044002800	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
365044002801	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044002802	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
365044002803	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044002804	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044002805	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
365044002806	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044002807	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
365044002808	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
365044002809	active site
365044002810	HIGH motif; other site
365044002811	dimer interface [polypeptide binding]; other site
365044002812	KMSKS motif; other site
365044002813	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
365044002814	putative active site [active]
365044002815	dimerization interface [polypeptide binding]; other site
365044002816	putative tRNAtyr binding site [nucleotide binding]; other site
365044002817	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
365044002818	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044002819	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
365044002820	RuvA N terminal domain; Region: RuvA_N; pfam01330
365044002821	Protein of unknown function (DUF511); Region: DUF511; cl01114
365044002822	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
365044002823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002824	Walker A motif; other site
365044002825	ATP binding site [chemical binding]; other site
365044002826	Walker B motif; other site
365044002827	arginine finger; other site
365044002828	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
365044002829	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
365044002830	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
365044002831	dimer interface [polypeptide binding]; other site
365044002832	active site
365044002833	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044002834	substrate binding site [chemical binding]; other site
365044002835	catalytic residue [active]
365044002836	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044002837	catalytic core [active]
365044002838	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
365044002839	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
365044002840	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
365044002841	Ligand Binding Site [chemical binding]; other site
365044002842	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
365044002843	active site
365044002844	pteridine reductase; Provisional; Region: PRK09135
365044002845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044002846	NAD(P) binding site [chemical binding]; other site
365044002847	active site
365044002848	Uncharacterized conserved protein [Function unknown]; Region: COG1565
365044002849	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
365044002850	HipA N-terminal domain; Region: Couple_hipA; cl11853
365044002851	HipA-like N-terminal domain; Region: HipA_N; pfam07805
365044002852	HipA-like C-terminal domain; Region: HipA_C; pfam07804
365044002853	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
365044002854	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044002855	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044002856	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
365044002857	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
365044002858	active site
365044002859	homotetramer interface [polypeptide binding]; other site
365044002860	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
365044002861	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
365044002862	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044002863	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
365044002864	lytic murein transglycosylase; Provisional; Region: PRK11619
365044002865	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044002866	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044002867	catalytic residue [active]
365044002868	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
365044002869	Helix-turn-helix domains; Region: HTH; cl00088
365044002870	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
365044002871	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
365044002872	dimerization interface [polypeptide binding]; other site
365044002873	substrate binding pocket [chemical binding]; other site
365044002874	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
365044002875	Sensors of blue-light using FAD; Region: BLUF; cl04855
365044002876	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044002877	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044002878	ligand binding site [chemical binding]; other site
365044002879	flexible hinge region; other site
365044002880	Helix-turn-helix domains; Region: HTH; cl00088
365044002881	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
365044002882	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
365044002883	Substrate binding site; other site
365044002884	Mg++ binding site; other site
365044002885	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
365044002886	active site
365044002887	substrate binding site [chemical binding]; other site
365044002888	CoA binding site [chemical binding]; other site
365044002889	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044002890	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044002891	putative DNA binding site [nucleotide binding]; other site
365044002892	putative Zn2+ binding site [ion binding]; other site
365044002893	AsnC family; Region: AsnC_trans_reg; pfam01037
365044002894	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
365044002895	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
365044002896	glutaminase active site [active]
365044002897	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
365044002898	dimer interface [polypeptide binding]; other site
365044002899	active site
365044002900	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
365044002901	dimer interface [polypeptide binding]; other site
365044002902	active site
365044002903	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044002904	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
365044002905	active site residue [active]
365044002906	serine O-acetyltransferase; Region: cysE; TIGR01172
365044002907	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365044002908	trimer interface [polypeptide binding]; other site
365044002909	active site
365044002910	substrate binding site [chemical binding]; other site
365044002911	CoA binding site [chemical binding]; other site
365044002912	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044002913	non-specific DNA binding site [nucleotide binding]; other site
365044002914	salt bridge; other site
365044002915	sequence-specific DNA binding site [nucleotide binding]; other site
365044002916	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044002917	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
365044002918	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
365044002919	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044002920	catalytic residue [active]
365044002921	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044002922	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044002923	substrate binding pocket [chemical binding]; other site
365044002924	membrane-bound complex binding site; other site
365044002925	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044002926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044002927	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044002928	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
365044002929	Walker A/P-loop; other site
365044002930	ATP binding site [chemical binding]; other site
365044002931	Q-loop/lid; other site
365044002932	ABC transporter signature motif; other site
365044002933	Walker B; other site
365044002934	D-loop; other site
365044002935	H-loop/switch region; other site
365044002936	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
365044002937	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
365044002938	active site
365044002939	dimer interface [polypeptide binding]; other site
365044002940	non-prolyl cis peptide bond; other site
365044002941	insertion regions; other site
365044002942	AMP-binding enzyme; Region: AMP-binding; cl15778
365044002943	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044002944	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044002945	Walker A/P-loop; other site
365044002946	ATP binding site [chemical binding]; other site
365044002947	Q-loop/lid; other site
365044002948	ABC transporter signature motif; other site
365044002949	Walker B; other site
365044002950	D-loop; other site
365044002951	H-loop/switch region; other site
365044002952	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044002953	TM-ABC transporter signature motif; other site
365044002954	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044002955	TM-ABC transporter signature motif; other site
365044002956	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
365044002957	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044002958	putative ligand binding site [chemical binding]; other site
365044002959	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
365044002960	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
365044002961	Flavin binding site [chemical binding]; other site
365044002962	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
365044002963	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044002964	active site
365044002965	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044002966	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044002967	Walker A/P-loop; other site
365044002968	ATP binding site [chemical binding]; other site
365044002969	Q-loop/lid; other site
365044002970	ABC transporter signature motif; other site
365044002971	Walker B; other site
365044002972	D-loop; other site
365044002973	H-loop/switch region; other site
365044002974	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044002975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044002976	Walker A motif; other site
365044002977	ATP binding site [chemical binding]; other site
365044002978	Walker B motif; other site
365044002979	arginine finger; other site
365044002980	Helix-turn-helix domains; Region: HTH; cl00088
365044002981	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
365044002982	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
365044002983	Flavin binding site [chemical binding]; other site
365044002984	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044002985	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
365044002986	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
365044002987	active site
365044002988	dimer interface [polypeptide binding]; other site
365044002989	non-prolyl cis peptide bond; other site
365044002990	insertion regions; other site
365044002991	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044002992	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
365044002993	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365044002994	dimer interface [polypeptide binding]; other site
365044002995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044002996	catalytic residue [active]
365044002997	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306
365044002998	substrate binding pocket [chemical binding]; other site
365044002999	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044003000	membrane-bound complex binding site; other site
365044003001	hinge residues; other site
365044003002	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044003003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003004	Walker A motif; other site
365044003005	ATP binding site [chemical binding]; other site
365044003006	Walker B motif; other site
365044003007	arginine finger; other site
365044003008	Helix-turn-helix domains; Region: HTH; cl00088
365044003009	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
365044003010	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365044003011	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
365044003012	DsbD alpha interface [polypeptide binding]; other site
365044003013	catalytic residues [active]
365044003014	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044003015	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044003016	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044003017	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044003018	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044003019	Cytochrome C'; Region: Cytochrom_C_2; cl01610
365044003020	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
365044003021	Strictosidine synthase; Region: Str_synth; pfam03088
365044003022	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
365044003023	catalytic triad [active]
365044003024	Cytochrome c; Region: Cytochrom_C; cl11414
365044003025	Cytochrome c; Region: Cytochrom_C; cl11414
365044003026	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
365044003027	Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583
365044003028	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
365044003029	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
365044003030	NMT1-like family; Region: NMT1_2; cl15260
365044003031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044003032	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044003033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044003034	dimer interface [polypeptide binding]; other site
365044003035	putative PBP binding loops; other site
365044003036	ABC-ATPase subunit interface; other site
365044003037	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
365044003038	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
365044003039	Walker A/P-loop; other site
365044003040	ATP binding site [chemical binding]; other site
365044003041	Q-loop/lid; other site
365044003042	ABC transporter signature motif; other site
365044003043	Walker B; other site
365044003044	D-loop; other site
365044003045	H-loop/switch region; other site
365044003046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044003047	TPR motif; other site
365044003048	binding surface
365044003049	Cytochrome C biogenesis protein; Region: CcmH; cl01179
365044003050	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
365044003051	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
365044003052	catalytic residues [active]
365044003053	central insert; other site
365044003054	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
365044003055	CcmE; Region: CcmE; cl00994
365044003056	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
365044003057	CcmB protein; Region: CcmB; cl01016
365044003058	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
365044003059	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044003060	Walker A/P-loop; other site
365044003061	ATP binding site [chemical binding]; other site
365044003062	Q-loop/lid; other site
365044003063	ABC transporter signature motif; other site
365044003064	Walker B; other site
365044003065	D-loop; other site
365044003066	H-loop/switch region; other site
365044003067	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044003068	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044003069	active site residue [active]
365044003070	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044003071	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044003072	Phage Tail Collar Domain; Region: Collar; pfam07484
365044003073	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
365044003074	FAD binding domain; Region: FAD_binding_4; pfam01565
365044003075	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
365044003076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003077	NMT1-like family; Region: NMT1_2; cl15260
365044003078	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
365044003079	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
365044003080	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044003081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044003082	DNA-binding site [nucleotide binding]; DNA binding site
365044003083	FCD domain; Region: FCD; cl11656
365044003084	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044003085	Helix-turn-helix domains; Region: HTH; cl00088
365044003086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003087	NMT1-like family; Region: NMT1_2; cl15260
365044003088	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044003089	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044003090	substrate binding site [chemical binding]; other site
365044003091	oxyanion hole (OAH) forming residues; other site
365044003092	trimer interface [polypeptide binding]; other site
365044003093	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044003094	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
365044003095	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
365044003096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044003097	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044003098	putative substrate translocation pore; other site
365044003099	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044003100	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
365044003101	NAD(P) binding site [chemical binding]; other site
365044003102	catalytic residues [active]
365044003103	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
365044003104	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
365044003105	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044003106	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
365044003107	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044003108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044003109	Probable transposase; Region: OrfB_IS605; pfam01385
365044003110	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044003111	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044003112	active site
365044003113	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044003114	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
365044003115	active site
365044003116	metal binding site [ion binding]; metal-binding site
365044003117	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044003118	Helix-turn-helix domains; Region: HTH; cl00088
365044003119	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044003120	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
365044003121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044003122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003123	NMT1-like family; Region: NMT1_2; cl15260
365044003124	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044003125	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044003126	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
365044003127	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044003128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003129	Walker A motif; other site
365044003130	ATP binding site [chemical binding]; other site
365044003131	Walker B motif; other site
365044003132	arginine finger; other site
365044003133	Helix-turn-helix domains; Region: HTH; cl00088
365044003134	Helix-turn-helix domains; Region: HTH; cl00088
365044003135	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
365044003136	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
365044003137	NADP binding site [chemical binding]; other site
365044003138	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044003139	active site
365044003140	substrate binding site [chemical binding]; other site
365044003141	Endonuclease I; Region: Endonuclease_1; cl01003
365044003142	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044003143	Putative phage integrase; Region: Phage_Integr_2; pfam13009
365044003144	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
365044003145	DNA binding site [nucleotide binding]
365044003146	active site
365044003147	Int/Topo IB signature motif; other site
365044003148	catalytic residues [active]
365044003149	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044003150	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
365044003151	active site
365044003152	Mg2+ binding site [ion binding]; other site
365044003153	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
365044003154	putative cation:proton antiport protein; Provisional; Region: PRK10669
365044003155	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
365044003156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044003157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
365044003158	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
365044003159	AAA domain; Region: AAA_33; pfam13671
365044003160	ATP-binding site [chemical binding]; other site
365044003161	Gluconate-6-phosphate binding site [chemical binding]; other site
365044003162	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
365044003163	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
365044003164	Ligand Binding Site [chemical binding]; other site
365044003165	Transmembrane secretion effector; Region: MFS_3; pfam05977
365044003166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044003167	putative substrate translocation pore; other site
365044003168	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044003169	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
365044003170	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044003171	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
365044003172	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
365044003173	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
365044003174	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
365044003175	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
365044003176	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
365044003177	putative dimer interface [polypeptide binding]; other site
365044003178	active site pocket [active]
365044003179	putative cataytic base [active]
365044003180	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
365044003181	threonine dehydratase; Reviewed; Region: PRK09224
365044003182	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
365044003183	tetramer interface [polypeptide binding]; other site
365044003184	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044003185	catalytic residue [active]
365044003186	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
365044003187	putative Ile/Val binding site [chemical binding]; other site
365044003188	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
365044003189	putative Ile/Val binding site [chemical binding]; other site
365044003190	OsmC-like protein; Region: OsmC; cl00767
365044003191	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
365044003192	diiron binding motif [ion binding]; other site
365044003193	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003194	trimer interface [polypeptide binding]; other site
365044003195	eyelet of channel; other site
365044003196	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003197	eyelet of channel; other site
365044003198	trimer interface [polypeptide binding]; other site
365044003199	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003200	trimer interface [polypeptide binding]; other site
365044003201	eyelet of channel; other site
365044003202	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
365044003203	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
365044003204	metal binding site [ion binding]; metal-binding site
365044003205	putative dimer interface [polypeptide binding]; other site
365044003206	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
365044003207	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
365044003208	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
365044003209	putative active site [active]
365044003210	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
365044003211	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
365044003212	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
365044003213	transaldolase-like protein; Provisional; Region: PTZ00411
365044003214	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
365044003215	active site
365044003216	dimer interface [polypeptide binding]; other site
365044003217	catalytic residue [active]
365044003218	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
365044003219	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
365044003220	active site
365044003221	dimer interface [polypeptide binding]; other site
365044003222	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
365044003223	dimer interface [polypeptide binding]; other site
365044003224	active site
365044003225	Protein of unknown function (DUF805); Region: DUF805; cl01224
365044003226	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
365044003227	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
365044003228	ring oligomerisation interface [polypeptide binding]; other site
365044003229	ATP/Mg binding site [chemical binding]; other site
365044003230	stacking interactions; other site
365044003231	hinge regions; other site
365044003232	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
365044003233	oligomerisation interface [polypeptide binding]; other site
365044003234	mobile loop; other site
365044003235	roof hairpin; other site
365044003236	S-adenosylmethionine synthetase; Validated; Region: PRK05250
365044003237	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
365044003238	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
365044003239	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
365044003240	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
365044003241	putative acyl-acceptor binding pocket; other site
365044003242	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
365044003243	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
365044003244	putative acyl-acceptor binding pocket; other site
365044003245	Predicted GTPase [General function prediction only]; Region: COG0218
365044003246	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
365044003247	G1 box; other site
365044003248	GTP/Mg2+ binding site [chemical binding]; other site
365044003249	Switch I region; other site
365044003250	G2 box; other site
365044003251	G3 box; other site
365044003252	Switch II region; other site
365044003253	G4 box; other site
365044003254	G5 box; other site
365044003255	Cytochrome c; Region: Cytochrom_C; cl11414
365044003256	Cytochrome c; Region: Cytochrom_C; cl11414
365044003257	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
365044003258	ResB-like family; Region: ResB; pfam05140
365044003259	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
365044003260	TMAO/DMSO reductase; Reviewed; Region: PRK05363
365044003261	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
365044003262	Moco binding site; other site
365044003263	metal coordination site [ion binding]; other site
365044003264	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
365044003265	diaminopimelate decarboxylase; Region: lysA; TIGR01048
365044003266	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
365044003267	active site
365044003268	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
365044003269	substrate binding site [chemical binding]; other site
365044003270	catalytic residues [active]
365044003271	dimer interface [polypeptide binding]; other site
365044003272	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503
365044003273	putative iron binding site [ion binding]; other site
365044003274	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
365044003275	Transglycosylase; Region: Transgly; cl07896
365044003276	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044003277	Competence protein A; Region: Competence_A; pfam11104
365044003278	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
365044003279	Pilus assembly protein, PilO; Region: PilO; cl01234
365044003280	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
365044003281	Pilus assembly protein, PilP; Region: PilP; pfam04351
365044003282	AMIN domain; Region: AMIN; pfam11741
365044003283	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
365044003284	Secretin and TonB N terminus short domain; Region: STN; cl06624
365044003285	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003286	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
365044003287	shikimate kinase; Reviewed; Region: aroK; PRK00131
365044003288	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
365044003289	ADP binding site [chemical binding]; other site
365044003290	magnesium binding site [ion binding]; other site
365044003291	putative shikimate binding site; other site
365044003292	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
365044003293	active site
365044003294	dimer interface [polypeptide binding]; other site
365044003295	metal binding site [ion binding]; metal-binding site
365044003296	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
365044003297	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365044003298	Zn2+ binding site [ion binding]; other site
365044003299	Mg2+ binding site [ion binding]; other site
365044003300	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
365044003301	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044003302	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044003303	putative ligand binding site [chemical binding]; other site
365044003304	Transposase IS200 like; Region: Y1_Tnp; cl00848
365044003305	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
365044003306	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
365044003307	active site
365044003308	dimer interface [polypeptide binding]; other site
365044003309	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
365044003310	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
365044003311	active site
365044003312	FMN binding site [chemical binding]; other site
365044003313	substrate binding site [chemical binding]; other site
365044003314	3Fe-4S cluster binding site [ion binding]; other site
365044003315	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
365044003316	domain interface; other site
365044003317	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
365044003318	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044003319	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
365044003320	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
365044003321	Walker A/P-loop; other site
365044003322	ATP binding site [chemical binding]; other site
365044003323	Q-loop/lid; other site
365044003324	ABC transporter signature motif; other site
365044003325	Walker B; other site
365044003326	D-loop; other site
365044003327	H-loop/switch region; other site
365044003328	Permease; Region: Permease; cl00510
365044003329	mce related protein; Region: MCE; pfam02470
365044003330	VacJ like lipoprotein; Region: VacJ; cl01073
365044003331	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
365044003332	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
365044003333	anti sigma factor interaction site; other site
365044003334	regulatory phosphorylation site [posttranslational modification]; other site
365044003335	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
365044003336	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
365044003337	Walker A/P-loop; other site
365044003338	ATP binding site [chemical binding]; other site
365044003339	Q-loop/lid; other site
365044003340	ABC transporter signature motif; other site
365044003341	Walker B; other site
365044003342	D-loop; other site
365044003343	H-loop/switch region; other site
365044003344	ABC-2 type transporter; Region: ABC2_membrane; cl11417
365044003345	BolA-like protein; Region: BolA; cl00386
365044003346	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
365044003347	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
365044003348	hinge; other site
365044003349	active site
365044003350	ATP phosphoribosyltransferase; Region: HisG; cl15266
365044003351	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
365044003352	histidinol dehydrogenase; Region: hisD; TIGR00069
365044003353	NAD binding site [chemical binding]; other site
365044003354	dimerization interface [polypeptide binding]; other site
365044003355	product binding site; other site
365044003356	substrate binding site [chemical binding]; other site
365044003357	zinc binding site [ion binding]; other site
365044003358	catalytic residues [active]
365044003359	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
365044003360	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044003361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044003362	homodimer interface [polypeptide binding]; other site
365044003363	catalytic residue [active]
365044003364	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
365044003365	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
365044003366	putative active site pocket [active]
365044003367	4-fold oligomerization interface [polypeptide binding]; other site
365044003368	metal binding residues [ion binding]; metal-binding site
365044003369	3-fold/trimer interface [polypeptide binding]; other site
365044003370	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
365044003371	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
365044003372	putative active site [active]
365044003373	oxyanion strand; other site
365044003374	catalytic triad [active]
365044003375	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
365044003376	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
365044003377	catalytic residues [active]
365044003378	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
365044003379	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
365044003380	substrate binding site [chemical binding]; other site
365044003381	glutamase interaction surface [polypeptide binding]; other site
365044003382	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
365044003383	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
365044003384	metal binding site [ion binding]; metal-binding site
365044003385	Predicted membrane protein [Function unknown]; Region: COG3671
365044003386	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
365044003387	nucleotide binding site/active site [active]
365044003388	HIT family signature motif; other site
365044003389	catalytic residue [active]
365044003390	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
365044003391	twin arginine translocase protein A; Validated; Region: tatE; PRK01614
365044003392	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
365044003393	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
365044003394	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
365044003395	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044003396	protein binding site [polypeptide binding]; other site
365044003397	Uncharacterized conserved protein [Function unknown]; Region: COG0327
365044003398	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
365044003399	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
365044003400	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
365044003401	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
365044003402	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
365044003403	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
365044003404	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
365044003405	[2Fe-2S] cluster binding site [ion binding]; other site
365044003406	cytochrome b; Provisional; Region: CYTB; MTH00145
365044003407	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
365044003408	Qi binding site; other site
365044003409	intrachain domain interface; other site
365044003410	interchain domain interface [polypeptide binding]; other site
365044003411	heme bH binding site [chemical binding]; other site
365044003412	heme bL binding site [chemical binding]; other site
365044003413	Qo binding site; other site
365044003414	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
365044003415	interchain domain interface [polypeptide binding]; other site
365044003416	intrachain domain interface; other site
365044003417	Qi binding site; other site
365044003418	Qo binding site; other site
365044003419	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
365044003420	stringent starvation protein A; Provisional; Region: sspA; PRK09481
365044003421	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
365044003422	C-terminal domain interface [polypeptide binding]; other site
365044003423	putative GSH binding site (G-site) [chemical binding]; other site
365044003424	dimer interface [polypeptide binding]; other site
365044003425	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
365044003426	dimer interface [polypeptide binding]; other site
365044003427	N-terminal domain interface [polypeptide binding]; other site
365044003428	Stringent starvation protein B; Region: SspB; cl01120
365044003429	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
365044003430	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044003431	Walker A/P-loop; other site
365044003432	ATP binding site [chemical binding]; other site
365044003433	Q-loop/lid; other site
365044003434	ABC transporter signature motif; other site
365044003435	Walker B; other site
365044003436	D-loop; other site
365044003437	H-loop/switch region; other site
365044003438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003439	NMT1-like family; Region: NMT1_2; cl15260
365044003440	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044003441	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003442	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003443	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003444	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
365044003445	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
365044003446	ligand binding site [chemical binding]; other site
365044003447	ABC-2 type transporter; Region: ABC2_membrane; cl11417
365044003448	Predicted secreted protein [Function unknown]; Region: COG5501
365044003449	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
365044003450	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
365044003451	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044003452	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
365044003453	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
365044003454	dimer interface [polypeptide binding]; other site
365044003455	Trp docking motif [polypeptide binding]; other site
365044003456	active site
365044003457	Cytochrome c; Region: Cytochrom_C; cl11414
365044003458	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
365044003459	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044003460	FeS/SAM binding site; other site
365044003461	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
365044003462	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
365044003463	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
365044003464	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044003465	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044003466	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044003467	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044003468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003469	Walker A motif; other site
365044003470	ATP binding site [chemical binding]; other site
365044003471	Walker B motif; other site
365044003472	arginine finger; other site
365044003473	Helix-turn-helix domains; Region: HTH; cl00088
365044003474	Cytochrome c; Region: Cytochrom_C; cl11414
365044003475	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044003476	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044003477	substrate binding pocket [chemical binding]; other site
365044003478	membrane-bound complex binding site; other site
365044003479	hinge residues; other site
365044003480	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
365044003481	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
365044003482	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
365044003483	SEC-C motif; Region: SEC-C; pfam02810
365044003484	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
365044003485	heterotetramer interface [polypeptide binding]; other site
365044003486	active site pocket [active]
365044003487	cleavage site
365044003488	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
365044003489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003490	Walker A motif; other site
365044003491	ATP binding site [chemical binding]; other site
365044003492	Walker B motif; other site
365044003493	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
365044003494	active site
365044003495	8-oxo-dGMP binding site [chemical binding]; other site
365044003496	nudix motif; other site
365044003497	metal binding site [ion binding]; metal-binding site
365044003498	patatin-related protein; Region: TIGR03607
365044003499	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
365044003500	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
365044003501	Domain of unknown function DUF21; Region: DUF21; pfam01595
365044003502	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365044003503	Transporter associated domain; Region: CorC_HlyC; cl08393
365044003504	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
365044003505	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044003506	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044003507	catalytic residue [active]
365044003508	prolyl-tRNA synthetase; Provisional; Region: PRK09194
365044003509	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
365044003510	dimer interface [polypeptide binding]; other site
365044003511	motif 1; other site
365044003512	active site
365044003513	motif 2; other site
365044003514	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
365044003515	putative deacylase active site [active]
365044003516	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
365044003517	active site
365044003518	motif 3; other site
365044003519	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
365044003520	anticodon binding site; other site
365044003521	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
365044003522	putative active site [active]
365044003523	Ap4A binding site [chemical binding]; other site
365044003524	nudix motif; other site
365044003525	putative metal binding site [ion binding]; other site
365044003526	CNP1-like family; Region: CNP1; pfam08750
365044003527	gamma-glutamyl kinase; Provisional; Region: PRK05429
365044003528	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
365044003529	nucleotide binding site [chemical binding]; other site
365044003530	homotetrameric interface [polypeptide binding]; other site
365044003531	putative phosphate binding site [ion binding]; other site
365044003532	putative allosteric binding site; other site
365044003533	PUA domain; Region: PUA; cl00607
365044003534	GTPase CgtA; Reviewed; Region: obgE; PRK12299
365044003535	GTP1/OBG; Region: GTP1_OBG; pfam01018
365044003536	Obg GTPase; Region: Obg; cd01898
365044003537	G1 box; other site
365044003538	GTP/Mg2+ binding site [chemical binding]; other site
365044003539	Switch I region; other site
365044003540	G2 box; other site
365044003541	G3 box; other site
365044003542	Switch II region; other site
365044003543	G4 box; other site
365044003544	G5 box; other site
365044003545	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
365044003546	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
365044003547	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
365044003548	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
365044003549	substrate binding pocket [chemical binding]; other site
365044003550	chain length determination region; other site
365044003551	substrate-Mg2+ binding site; other site
365044003552	catalytic residues [active]
365044003553	aspartate-rich region 1; other site
365044003554	active site lid residues [active]
365044003555	aspartate-rich region 2; other site
365044003556	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
365044003557	type II secretion system protein F; Region: GspF; TIGR02120
365044003558	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
365044003559	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
365044003560	type II secretion system protein E; Region: type_II_gspE; TIGR02533
365044003561	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
365044003562	Walker A motif; other site
365044003563	ATP binding site [chemical binding]; other site
365044003564	Walker B motif; other site
365044003565	type II secretion system protein D; Region: type_II_gspD; TIGR02517
365044003566	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003567	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003568	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
365044003569	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
365044003570	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
365044003571	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
365044003572	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
365044003573	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
365044003574	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
365044003575	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
365044003576	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
365044003577	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
365044003578	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044003579	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
365044003580	Walker A motif; other site
365044003581	ATP binding site [chemical binding]; other site
365044003582	Walker B motif; other site
365044003583	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
365044003584	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
365044003585	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
365044003586	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
365044003587	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
365044003588	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
365044003589	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
365044003590	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
365044003591	CoA-binding site [chemical binding]; other site
365044003592	ATP-binding [chemical binding]; other site
365044003593	Protein of unknown function (DUF1342); Region: DUF1342; cl01892
365044003594	Domain of unknown function (DUF329); Region: DUF329; cl01144
365044003595	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
365044003596	putative GSH binding site [chemical binding]; other site
365044003597	catalytic residues [active]
365044003598	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
365044003599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044003600	peptide chain release factor 1; Validated; Region: prfA; PRK00591
365044003601	RF-1 domain; Region: RF-1; cl02875
365044003602	RF-1 domain; Region: RF-1; cl02875
365044003603	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
365044003604	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
365044003605	tRNA; other site
365044003606	putative tRNA binding site [nucleotide binding]; other site
365044003607	putative NADP binding site [chemical binding]; other site
365044003608	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
365044003609	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
365044003610	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044003611	FAD binding domain; Region: FAD_binding_4; pfam01565
365044003612	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044003613	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
365044003614	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
365044003615	Cysteine-rich domain; Region: CCG; pfam02754
365044003616	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
365044003617	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
365044003618	HIT family signature motif; other site
365044003619	catalytic residue [active]
365044003620	Protein of unknown function (DUF971); Region: DUF971; cl01414
365044003621	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
365044003622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044003623	S-adenosylmethionine binding site [chemical binding]; other site
365044003624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044003625	Tim44-like domain; Region: Tim44; cl09208
365044003626	SCP-2 sterol transfer family; Region: SCP2; cl01225
365044003627	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044003628	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
365044003629	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
365044003630	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
365044003631	Protein of unknown function (DUF502); Region: DUF502; cl01107
365044003632	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
365044003633	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
365044003634	dimer interface [polypeptide binding]; other site
365044003635	anticodon binding site; other site
365044003636	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
365044003637	homodimer interface [polypeptide binding]; other site
365044003638	motif 1; other site
365044003639	active site
365044003640	motif 2; other site
365044003641	GAD domain; Region: GAD; pfam02938
365044003642	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
365044003643	motif 3; other site
365044003644	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044003645	Ligand Binding Site [chemical binding]; other site
365044003646	Histidine kinase; Region: HisKA_3; pfam07730
365044003647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044003648	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044003649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044003650	active site
365044003651	phosphorylation site [posttranslational modification]
365044003652	intermolecular recognition site; other site
365044003653	dimerization interface [polypeptide binding]; other site
365044003654	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044003655	DNA binding residues [nucleotide binding]
365044003656	dimerization interface [polypeptide binding]; other site
365044003657	Response regulator receiver domain; Region: Response_reg; pfam00072
365044003658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044003659	active site
365044003660	phosphorylation site [posttranslational modification]
365044003661	intermolecular recognition site; other site
365044003662	dimerization interface [polypeptide binding]; other site
365044003663	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
365044003664	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044003665	ligand binding site [chemical binding]; other site
365044003666	flexible hinge region; other site
365044003667	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044003668	putative switch regulator; other site
365044003669	non-specific DNA interactions [nucleotide binding]; other site
365044003670	DNA binding site [nucleotide binding]
365044003671	sequence specific DNA binding site [nucleotide binding]; other site
365044003672	putative cAMP binding site [chemical binding]; other site
365044003673	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044003674	feruloyl-CoA synthase; Reviewed; Region: PRK08180
365044003675	AMP-binding enzyme; Region: AMP-binding; cl15778
365044003676	putative acyltransferase; Provisional; Region: PRK05790
365044003677	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044003678	dimer interface [polypeptide binding]; other site
365044003679	active site
365044003680	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
365044003681	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
365044003682	NAD binding site [chemical binding]; other site
365044003683	homodimer interface [polypeptide binding]; other site
365044003684	homotetramer interface [polypeptide binding]; other site
365044003685	active site
365044003686	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044003687	active site
365044003688	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044003689	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
365044003690	putative ligand binding site [chemical binding]; other site
365044003691	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
365044003692	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044003693	TM-ABC transporter signature motif; other site
365044003694	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044003695	TM-ABC transporter signature motif; other site
365044003696	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044003697	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044003698	Walker A/P-loop; other site
365044003699	ATP binding site [chemical binding]; other site
365044003700	Q-loop/lid; other site
365044003701	ABC transporter signature motif; other site
365044003702	Walker B; other site
365044003703	D-loop; other site
365044003704	H-loop/switch region; other site
365044003705	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044003706	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044003707	Walker A/P-loop; other site
365044003708	ATP binding site [chemical binding]; other site
365044003709	Q-loop/lid; other site
365044003710	ABC transporter signature motif; other site
365044003711	Walker B; other site
365044003712	D-loop; other site
365044003713	H-loop/switch region; other site
365044003714	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044003715	trimer interface [polypeptide binding]; other site
365044003716	eyelet of channel; other site
365044003717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003718	NMT1-like family; Region: NMT1_2; cl15260
365044003719	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044003720	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044003721	active site
365044003722	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044003723	Helix-turn-helix domains; Region: HTH; cl00088
365044003724	Helix-turn-helix domains; Region: HTH; cl00088
365044003725	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
365044003726	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
365044003727	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365044003728	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
365044003729	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
365044003730	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
365044003731	synthetase active site [active]
365044003732	NTP binding site [chemical binding]; other site
365044003733	metal binding site [ion binding]; metal-binding site
365044003734	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
365044003735	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
365044003736	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
365044003737	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
365044003738	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
365044003739	catalytic site [active]
365044003740	G-X2-G-X-G-K; other site
365044003741	hypothetical protein; Provisional; Region: PRK11820
365044003742	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
365044003743	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
365044003744	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
365044003745	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044003746	active site
365044003747	ATP binding site [chemical binding]; other site
365044003748	substrate binding site [chemical binding]; other site
365044003749	activation loop (A-loop); other site
365044003750	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044003751	Protein phosphatase 2C; Region: PP2C; pfam00481
365044003752	active site
365044003753	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
365044003754	active site
365044003755	dimerization interface [polypeptide binding]; other site
365044003756	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
365044003757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044003758	FeS/SAM binding site; other site
365044003759	HemN C-terminal domain; Region: HemN_C; pfam06969
365044003760	ADP-dependent glucokinase; Provisional; Region: PRK14039
365044003761	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
365044003762	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
365044003763	active site
365044003764	HIGH motif; other site
365044003765	KMSKS motif; other site
365044003766	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
365044003767	anticodon binding site; other site
365044003768	tRNA binding surface [nucleotide binding]; other site
365044003769	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
365044003770	dimer interface [polypeptide binding]; other site
365044003771	putative tRNA-binding site [nucleotide binding]; other site
365044003772	Found in ATP-dependent protease La (LON); Region: LON; smart00464
365044003773	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
365044003774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003775	Walker A motif; other site
365044003776	ATP binding site [chemical binding]; other site
365044003777	Walker B motif; other site
365044003778	arginine finger; other site
365044003779	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
365044003780	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
365044003781	hypothetical protein; Provisional; Region: PRK08609
365044003782	active site
365044003783	primer binding site [nucleotide binding]; other site
365044003784	NTP  binding site [chemical binding]; other site
365044003785	metal binding triad [ion binding]; metal-binding site
365044003786	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
365044003787	30S subunit binding site; other site
365044003788	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
365044003789	DNA-binding site [nucleotide binding]; DNA binding site
365044003790	RNA-binding motif; other site
365044003791	antiporter inner membrane protein; Provisional; Region: PRK11670
365044003792	Domain of unknown function DUF59; Region: DUF59; cl00941
365044003793	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
365044003794	Walker A motif; other site
365044003795	Helix-turn-helix domains; Region: HTH; cl00088
365044003796	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
365044003797	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044003798	dimerization interface [polypeptide binding]; other site
365044003799	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
365044003800	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
365044003801	putative dimer interface [polypeptide binding]; other site
365044003802	[2Fe-2S] cluster binding site [ion binding]; other site
365044003803	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
365044003804	SLBB domain; Region: SLBB; pfam10531
365044003805	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
365044003806	NlpC/P60 family; Region: NLPC_P60; cl11438
365044003807	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
365044003808	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
365044003809	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
365044003810	4Fe-4S binding domain; Region: Fer4; cl02805
365044003811	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044003812	4Fe-4S binding domain; Region: Fer4; cl02805
365044003813	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
365044003814	4Fe-4S binding domain; Region: Fer4; cl02805
365044003815	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
365044003816	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
365044003817	[4Fe-4S] binding site [ion binding]; other site
365044003818	molybdopterin cofactor binding site; other site
365044003819	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044003820	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
365044003821	molybdopterin cofactor binding site; other site
365044003822	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
365044003823	4Fe-4S binding domain; Region: Fer4; cl02805
365044003824	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044003825	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
365044003826	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
365044003827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003828	NMT1-like family; Region: NMT1_2; cl15260
365044003829	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
365044003830	classical (c) SDRs; Region: SDR_c; cd05233
365044003831	NAD(P) binding site [chemical binding]; other site
365044003832	active site
365044003833	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044003834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003835	NMT1-like family; Region: NMT1_2; cl15260
365044003836	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
365044003837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044003838	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044003839	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
365044003840	dimer interface [polypeptide binding]; other site
365044003841	active site
365044003842	coenzyme A binding site [chemical binding]; other site
365044003843	citrylCoA binding site [chemical binding]; other site
365044003844	Citrate synthase; Region: Citrate_synt; pfam00285
365044003845	oxalacetate/citrate binding site [chemical binding]; other site
365044003846	catalytic triad [active]
365044003847	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
365044003848	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044003849	apolar tunnel; other site
365044003850	heme binding site [chemical binding]; other site
365044003851	dimerization interface [polypeptide binding]; other site
365044003852	phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185
365044003853	MORN repeat; Region: MORN; cl14787
365044003854	MORN repeat; Region: MORN; cl14787
365044003855	MORN repeat; Region: MORN; cl14787
365044003856	MORN repeat; Region: MORN; cl14787
365044003857	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365044003858	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
365044003859	Walker A/P-loop; other site
365044003860	ATP binding site [chemical binding]; other site
365044003861	Q-loop/lid; other site
365044003862	ABC transporter signature motif; other site
365044003863	Walker B; other site
365044003864	D-loop; other site
365044003865	H-loop/switch region; other site
365044003866	TOBE domain; Region: TOBE_2; cl01440
365044003867	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044003868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044003869	CsbD-like; Region: CsbD; cl15799
365044003870	PAS fold; Region: PAS_4; pfam08448
365044003871	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044003872	GAF domain; Region: GAF; cl15785
365044003873	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044003874	dimer interface [polypeptide binding]; other site
365044003875	phosphorylation site [posttranslational modification]
365044003876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044003877	ATP binding site [chemical binding]; other site
365044003878	Mg2+ binding site [ion binding]; other site
365044003879	G-X-G motif; other site
365044003880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044003881	Response regulator receiver domain; Region: Response_reg; pfam00072
365044003882	active site
365044003883	phosphorylation site [posttranslational modification]
365044003884	intermolecular recognition site; other site
365044003885	dimerization interface [polypeptide binding]; other site
365044003886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
365044003887	Family of unknown function (DUF490); Region: DUF490; pfam04357
365044003888	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
365044003889	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044003890	Surface antigen; Region: Bac_surface_Ag; cl03097
365044003891	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044003892	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
365044003893	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044003894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044003895	Walker A motif; other site
365044003896	ATP binding site [chemical binding]; other site
365044003897	Walker B motif; other site
365044003898	arginine finger; other site
365044003899	Cytochrome c; Region: Cytochrom_C; cl11414
365044003900	Cytochrome c; Region: Cytochrom_C; cl11414
365044003901	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
365044003902	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
365044003903	Helix-turn-helix domains; Region: HTH; cl00088
365044003904	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044003905	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044003906	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044003907	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
365044003908	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044003909	dimer interface [polypeptide binding]; other site
365044003910	active site
365044003911	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
365044003912	classical (c) SDRs; Region: SDR_c; cd05233
365044003913	NAD(P) binding site [chemical binding]; other site
365044003914	active site
365044003915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044003916	NMT1-like family; Region: NMT1_2; cl15260
365044003917	Predicted membrane protein [Function unknown]; Region: COG2860
365044003918	UPF0126 domain; Region: UPF0126; pfam03458
365044003919	Helix-turn-helix domains; Region: HTH; cl00088
365044003920	Winged helix-turn helix; Region: HTH_29; pfam13551
365044003921	Winged helix-turn helix; Region: HTH_33; pfam13592
365044003922	Integrase core domain; Region: rve; cl01316
365044003923	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
365044003924	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
365044003925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044003926	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
365044003927	putative active site [active]
365044003928	putative catalytic site [active]
365044003929	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
365044003930	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
365044003931	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044003932	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
365044003933	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168
365044003934	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
365044003935	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044003936	Cytochrome c; Region: Cytochrom_C; cl11414
365044003937	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
365044003938	Subunit I/III interface [polypeptide binding]; other site
365044003939	D-pathway; other site
365044003940	Subunit I/VIIc interface [polypeptide binding]; other site
365044003941	Subunit I/IV interface [polypeptide binding]; other site
365044003942	Subunit I/II interface [polypeptide binding]; other site
365044003943	Low-spin heme (heme a) binding site [chemical binding]; other site
365044003944	Subunit I/VIIa interface [polypeptide binding]; other site
365044003945	Subunit I/VIa interface [polypeptide binding]; other site
365044003946	Dimer interface; other site
365044003947	Putative water exit pathway; other site
365044003948	Binuclear center (heme a3/CuB) [ion binding]; other site
365044003949	K-pathway; other site
365044003950	Subunit I/Vb interface [polypeptide binding]; other site
365044003951	Putative proton exit pathway; other site
365044003952	Subunit I/VIb interface; other site
365044003953	Subunit I/VIc interface [polypeptide binding]; other site
365044003954	Electron transfer pathway; other site
365044003955	Subunit I/VIIIb interface [polypeptide binding]; other site
365044003956	Subunit I/VIIb interface [polypeptide binding]; other site
365044003957	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
365044003958	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
365044003959	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
365044003960	Subunit III/VIIa interface [polypeptide binding]; other site
365044003961	Phospholipid binding site [chemical binding]; other site
365044003962	Subunit I/III interface [polypeptide binding]; other site
365044003963	Subunit III/VIb interface [polypeptide binding]; other site
365044003964	Subunit III/VIa interface; other site
365044003965	Subunit III/Vb interface [polypeptide binding]; other site
365044003966	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
365044003967	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
365044003968	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
365044003969	UbiA prenyltransferase family; Region: UbiA; cl00337
365044003970	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
365044003971	Cu(I) binding site [ion binding]; other site
365044003972	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
365044003973	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044003974	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044003975	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
365044003976	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
365044003977	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044003978	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
365044003979	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
365044003980	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
365044003981	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
365044003982	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
365044003983	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
365044003984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044003985	S-adenosylmethionine binding site [chemical binding]; other site
365044003986	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
365044003987	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
365044003988	active site
365044003989	(T/H)XGH motif; other site
365044003990	ferredoxin; Validated; Region: PRK07118
365044003991	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
365044003992	putative active site [active]
365044003993	catalytic residue [active]
365044003994	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
365044003995	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
365044003996	5S rRNA interface [nucleotide binding]; other site
365044003997	CTC domain interface [polypeptide binding]; other site
365044003998	L16 interface [polypeptide binding]; other site
365044003999	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
365044004000	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
365044004001	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044004002	active site
365044004003	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
365044004004	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
365044004005	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
365044004006	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
365044004007	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
365044004008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044004009	binding surface
365044004010	TPR motif; other site
365044004011	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044004012	binding surface
365044004013	TPR motif; other site
365044004014	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
365044004015	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
365044004016	DNA binding site [nucleotide binding]
365044004017	catalytic residue [active]
365044004018	H2TH interface [polypeptide binding]; other site
365044004019	putative catalytic residues [active]
365044004020	turnover-facilitating residue; other site
365044004021	intercalation triad [nucleotide binding]; other site
365044004022	8OG recognition residue [nucleotide binding]; other site
365044004023	putative reading head residues; other site
365044004024	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
365044004025	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
365044004026	Dynamin family; Region: Dynamin_N; pfam00350
365044004027	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004028	G1 box; other site
365044004029	GTP/Mg2+ binding site [chemical binding]; other site
365044004030	G2 box; other site
365044004031	Switch I region; other site
365044004032	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
365044004033	G3 box; other site
365044004034	Switch II region; other site
365044004035	GTP/Mg2+ binding site [chemical binding]; other site
365044004036	G4 box; other site
365044004037	G5 box; other site
365044004038	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
365044004039	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044004040	minor groove reading motif; other site
365044004041	helix-hairpin-helix signature motif; other site
365044004042	substrate binding pocket [chemical binding]; other site
365044004043	active site
365044004044	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
365044004045	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
365044004046	DNA binding and oxoG recognition site [nucleotide binding]
365044004047	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
365044004048	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
365044004049	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
365044004050	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
365044004051	Walker A/P-loop; other site
365044004052	ATP binding site [chemical binding]; other site
365044004053	Q-loop/lid; other site
365044004054	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
365044004055	ABC transporter signature motif; other site
365044004056	Walker B; other site
365044004057	D-loop; other site
365044004058	H-loop/switch region; other site
365044004059	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
365044004060	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
365044004061	Helix-turn-helix domains; Region: HTH; cl00088
365044004062	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
365044004063	nudix motif; other site
365044004064	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
365044004065	putative active site [active]
365044004066	catalytic site [active]
365044004067	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
365044004068	PLD-like domain; Region: PLDc_2; pfam13091
365044004069	putative active site [active]
365044004070	catalytic site [active]
365044004071	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
365044004072	active site
365044004073	Sensors of blue-light using FAD; Region: BLUF; cl04855
365044004074	BON domain; Region: BON; cl02771
365044004075	outer membrane lipoprotein; Provisional; Region: PRK11023
365044004076	BON domain; Region: BON; cl02771
365044004077	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
365044004078	CHASE3 domain; Region: CHASE3; cl05000
365044004079	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044004080	Histidine kinase; Region: HisKA_3; pfam07730
365044004081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004082	ATP binding site [chemical binding]; other site
365044004083	Mg2+ binding site [ion binding]; other site
365044004084	G-X-G motif; other site
365044004085	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044004086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004087	active site
365044004088	phosphorylation site [posttranslational modification]
365044004089	intermolecular recognition site; other site
365044004090	dimerization interface [polypeptide binding]; other site
365044004091	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044004092	DNA binding residues [nucleotide binding]
365044004093	dimerization interface [polypeptide binding]; other site
365044004094	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044004095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004096	active site
365044004097	phosphorylation site [posttranslational modification]
365044004098	intermolecular recognition site; other site
365044004099	dimerization interface [polypeptide binding]; other site
365044004100	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
365044004101	AsmA-like C-terminal region; Region: AsmA_2; cl15864
365044004102	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
365044004103	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
365044004104	ATP binding site [chemical binding]; other site
365044004105	substrate interface [chemical binding]; other site
365044004106	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
365044004107	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
365044004108	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
365044004109	protein binding site [polypeptide binding]; other site
365044004110	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
365044004111	Catalytic dyad [active]
365044004112	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044004113	catalytic core [active]
365044004114	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044004115	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
365044004116	active site residue [active]
365044004117	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
365044004118	GSH binding site [chemical binding]; other site
365044004119	catalytic residues [active]
365044004120	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
365044004121	SecA binding site; other site
365044004122	Preprotein binding site; other site
365044004123	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
365044004124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044004125	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
365044004126	Cupin domain; Region: Cupin_2; cl09118
365044004127	pantoate--beta-alanine ligase; Region: panC; TIGR00018
365044004128	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044004129	active site
365044004130	nucleotide binding site [chemical binding]; other site
365044004131	HIGH motif; other site
365044004132	KMSKS motif; other site
365044004133	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
365044004134	oligomerization interface [polypeptide binding]; other site
365044004135	active site
365044004136	metal binding site [ion binding]; metal-binding site
365044004137	Short C-terminal domain; Region: SHOCT; cl01373
365044004138	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
365044004139	tetramerization interface [polypeptide binding]; other site
365044004140	active site
365044004141	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
365044004142	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
365044004143	dimerization interface [polypeptide binding]; other site
365044004144	active site
365044004145	Quinolinate synthetase A protein; Region: NadA; cl00420
365044004146	aminodeoxychorismate synthase; Provisional; Region: PRK07508
365044004147	chorismate binding enzyme; Region: Chorismate_bind; cl10555
365044004148	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
365044004149	substrate-cofactor binding pocket; other site
365044004150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044004151	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
365044004152	SecA binding site; other site
365044004153	Preprotein binding site; other site
365044004154	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
365044004155	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
365044004156	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
365044004157	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
365044004158	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044004159	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
365044004160	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044004161	GAF domain; Region: GAF; cl15785
365044004162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044004163	Walker A motif; other site
365044004164	ATP binding site [chemical binding]; other site
365044004165	Walker B motif; other site
365044004166	arginine finger; other site
365044004167	Helix-turn-helix domains; Region: HTH; cl00088
365044004168	DTW domain; Region: DTW; cl01221
365044004169	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
365044004170	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044004171	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
365044004172	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
365044004173	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044004174	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044004175	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913
365044004176	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
365044004177	Acyl transferase domain; Region: Acyl_transf_1; cl08282
365044004178	Malonate/sodium symporter MadM subunit; Region: MadM; cl04274
365044004179	Malonate transporter MadL subunit; Region: MadL; cl04273
365044004180	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004181	Helix-turn-helix domains; Region: HTH; cl00088
365044004182	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
365044004183	putative dimerization interface [polypeptide binding]; other site
365044004184	L-aspartate oxidase; Provisional; Region: PRK09077
365044004185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044004186	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
365044004187	ScpA/B protein; Region: ScpA_ScpB; cl00598
365044004188	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
365044004189	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
365044004190	Sulfate transporter family; Region: Sulfate_transp; cl15842
365044004191	putative transporter; Provisional; Region: PRK11660
365044004192	Sulfate transporter family; Region: Sulfate_transp; cl15842
365044004193	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
365044004194	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
365044004195	oligomer interface [polypeptide binding]; other site
365044004196	active site residues [active]
365044004197	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
365044004198	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
365044004199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
365044004200	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044004201	active site
365044004202	metal binding site [ion binding]; metal-binding site
365044004203	interdomain interaction site; other site
365044004204	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
365044004205	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365044004206	active site
365044004207	Int/Topo IB signature motif; other site
365044004208	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004209	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
365044004210	UreF; Region: UreF; pfam01730
365044004211	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
365044004212	dimer interface [polypeptide binding]; other site
365044004213	catalytic residues [active]
365044004214	urease subunit alpha; Reviewed; Region: ureC; PRK13207
365044004215	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
365044004216	subunit interactions [polypeptide binding]; other site
365044004217	active site
365044004218	flap region; other site
365044004219	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
365044004220	gamma-beta subunit interface [polypeptide binding]; other site
365044004221	alpha-beta subunit interface [polypeptide binding]; other site
365044004222	HupE / UreJ protein; Region: HupE_UreJ; cl01011
365044004223	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
365044004224	alpha-gamma subunit interface [polypeptide binding]; other site
365044004225	beta-gamma subunit interface [polypeptide binding]; other site
365044004226	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
365044004227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044004228	dimer interface [polypeptide binding]; other site
365044004229	phosphorylation site [posttranslational modification]
365044004230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004231	ATP binding site [chemical binding]; other site
365044004232	Mg2+ binding site [ion binding]; other site
365044004233	G-X-G motif; other site
365044004234	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004236	active site
365044004237	phosphorylation site [posttranslational modification]
365044004238	intermolecular recognition site; other site
365044004239	dimerization interface [polypeptide binding]; other site
365044004240	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004242	active site
365044004243	phosphorylation site [posttranslational modification]
365044004244	intermolecular recognition site; other site
365044004245	dimerization interface [polypeptide binding]; other site
365044004246	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
365044004247	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044004248	DNA binding residues [nucleotide binding]
365044004249	dimerization interface [polypeptide binding]; other site
365044004250	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
365044004251	rRNA binding site [nucleotide binding]; other site
365044004252	predicted 30S ribosome binding site; other site
365044004253	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
365044004254	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
365044004255	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
365044004256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004257	DEAD_2; Region: DEAD_2; pfam06733
365044004258	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004259	Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A...; Region: EH; cd00052
365044004260	pseudo EF-hand loop; other site
365044004261	EF-hand domain pair; Region: EF_hand_5; pfam13499
365044004262	peptide binding pocket; other site
365044004263	Ca2+ binding site [ion binding]; other site
365044004264	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365044004265	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
365044004266	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
365044004267	putative catalytic site [active]
365044004268	putative metal binding site [ion binding]; other site
365044004269	putative phosphate binding site [ion binding]; other site
365044004270	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
365044004271	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
365044004272	active site residues [active]
365044004273	dimer interface [polypeptide binding]; other site
365044004274	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
365044004275	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
365044004276	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
365044004277	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
365044004278	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
365044004279	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
365044004280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044004281	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044004282	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
365044004283	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004284	Walker A/P-loop; other site
365044004285	ATP binding site [chemical binding]; other site
365044004286	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
365044004287	putative active site [active]
365044004288	putative metal-binding site [ion binding]; other site
365044004289	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044004290	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
365044004291	putative ligand binding site [chemical binding]; other site
365044004292	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044004293	TM-ABC transporter signature motif; other site
365044004294	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044004295	TM-ABC transporter signature motif; other site
365044004296	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
365044004297	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044004298	Walker A/P-loop; other site
365044004299	ATP binding site [chemical binding]; other site
365044004300	Q-loop/lid; other site
365044004301	ABC transporter signature motif; other site
365044004302	Walker B; other site
365044004303	D-loop; other site
365044004304	H-loop/switch region; other site
365044004305	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
365044004306	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044004307	Walker A/P-loop; other site
365044004308	ATP binding site [chemical binding]; other site
365044004309	Q-loop/lid; other site
365044004310	ABC transporter signature motif; other site
365044004311	Walker B; other site
365044004312	D-loop; other site
365044004313	H-loop/switch region; other site
365044004314	UreD urease accessory protein; Region: UreD; cl00530
365044004315	cyanophycin synthetase; Provisional; Region: PRK14016
365044004316	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044004317	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044004318	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044004319	cyanophycin synthetase; Provisional; Region: PRK14016
365044004320	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044004321	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
365044004322	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044004323	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
365044004324	Walker A/P-loop; other site
365044004325	ATP binding site [chemical binding]; other site
365044004326	Q-loop/lid; other site
365044004327	ABC transporter signature motif; other site
365044004328	Walker B; other site
365044004329	D-loop; other site
365044004330	H-loop/switch region; other site
365044004331	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
365044004332	malic enzyme; Reviewed; Region: PRK12862
365044004333	Malic enzyme, N-terminal domain; Region: malic; pfam00390
365044004334	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
365044004335	putative NAD(P) binding site [chemical binding]; other site
365044004336	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
365044004337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044004338	NMT1-like family; Region: NMT1_2; cl15260
365044004339	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
365044004340	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
365044004341	XdhC Rossmann domain; Region: XdhC_C; pfam13478
365044004342	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044004343	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044004344	putative ligand binding site [chemical binding]; other site
365044004345	transcriptional regulator; Provisional; Region: PRK10632
365044004346	Helix-turn-helix domains; Region: HTH; cl00088
365044004347	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
365044004348	putative effector binding pocket; other site
365044004349	putative dimerization interface [polypeptide binding]; other site
365044004350	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
365044004351	tartrate dehydrogenase; Provisional; Region: PRK08194
365044004352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044004353	NMT1-like family; Region: NMT1_2; cl15260
365044004354	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
365044004355	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
365044004356	MOFRL family; Region: MOFRL; pfam05161
365044004357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044004358	NMT1-like family; Region: NMT1_2; cl15260
365044004359	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
365044004360	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
365044004361	phosphate binding site [ion binding]; other site
365044004362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044004363	NMT1-like family; Region: NMT1_2; cl15260
365044004364	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044004365	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044004366	NAD(P) binding site [chemical binding]; other site
365044004367	catalytic residues [active]
365044004368	benzoylformate decarboxylase; Reviewed; Region: PRK07092
365044004369	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365044004370	PYR/PP interface [polypeptide binding]; other site
365044004371	dimer interface [polypeptide binding]; other site
365044004372	TPP binding site [chemical binding]; other site
365044004373	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
365044004374	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
365044004375	TPP-binding site [chemical binding]; other site
365044004376	dimer interface [polypeptide binding]; other site
365044004377	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004378	Helix-turn-helix domains; Region: HTH; cl00088
365044004379	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
365044004380	substrate binding pocket [chemical binding]; other site
365044004381	dimerization interface [polypeptide binding]; other site
365044004382	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044004383	apolar tunnel; other site
365044004384	heme binding site [chemical binding]; other site
365044004385	dimerization interface [polypeptide binding]; other site
365044004386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004387	S-adenosylmethionine binding site [chemical binding]; other site
365044004388	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
365044004389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044004390	non-specific DNA binding site [nucleotide binding]; other site
365044004391	salt bridge; other site
365044004392	sequence-specific DNA binding site [nucleotide binding]; other site
365044004393	Cupin domain; Region: Cupin_2; cl09118
365044004394	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044004395	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044004396	substrate binding pocket [chemical binding]; other site
365044004397	membrane-bound complex binding site; other site
365044004398	hinge residues; other site
365044004399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044004400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044004401	dimer interface [polypeptide binding]; other site
365044004402	conserved gate region; other site
365044004403	putative PBP binding loops; other site
365044004404	ABC-ATPase subunit interface; other site
365044004405	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044004406	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
365044004407	Walker A/P-loop; other site
365044004408	ATP binding site [chemical binding]; other site
365044004409	Q-loop/lid; other site
365044004410	ABC transporter signature motif; other site
365044004411	Walker B; other site
365044004412	D-loop; other site
365044004413	H-loop/switch region; other site
365044004414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044004415	FAD dependent oxidoreductase; Region: DAO; pfam01266
365044004416	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
365044004417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004418	S-adenosylmethionine binding site [chemical binding]; other site
365044004419	Cytochrome c; Region: Cytochrom_C; cl11414
365044004420	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
365044004421	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
365044004422	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
365044004423	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
365044004424	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
365044004425	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
365044004426	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
365044004427	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
365044004428	Walker A/P-loop; other site
365044004429	ATP binding site [chemical binding]; other site
365044004430	Q-loop/lid; other site
365044004431	ABC transporter signature motif; other site
365044004432	Walker B; other site
365044004433	D-loop; other site
365044004434	H-loop/switch region; other site
365044004435	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
365044004436	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
365044004437	TM-ABC transporter signature motif; other site
365044004438	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
365044004439	TM-ABC transporter signature motif; other site
365044004440	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
365044004441	putative ligand binding site [chemical binding]; other site
365044004442	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
365044004443	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
365044004444	active site
365044004445	purine riboside binding site [chemical binding]; other site
365044004446	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
365044004447	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
365044004448	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
365044004449	putative ligand binding site [chemical binding]; other site
365044004450	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
365044004451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044004452	FeS/SAM binding site; other site
365044004453	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
365044004454	active site
365044004455	guanine deaminase; Provisional; Region: PRK09228
365044004456	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044004457	active site
365044004458	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
365044004459	trimer interface [polypeptide binding]; other site
365044004460	active site
365044004461	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
365044004462	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
365044004463	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
365044004464	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
365044004465	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044004466	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
365044004467	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044004468	Probable transposase; Region: OrfB_IS605; pfam01385
365044004469	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044004470	UDP-glucose 4-epimerase; Region: PLN02240
365044004471	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
365044004472	NAD binding site [chemical binding]; other site
365044004473	homodimer interface [polypeptide binding]; other site
365044004474	active site
365044004475	substrate binding site [chemical binding]; other site
365044004476	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044004477	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044004478	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004479	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044004480	Short C-terminal domain; Region: SHOCT; cl01373
365044004481	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004482	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044004483	Uncharacterized conserved protein [Function unknown]; Region: COG2308
365044004484	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
365044004485	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
365044004486	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044004487	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004488	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044004489	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
365044004490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
365044004491	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
365044004492	AMP binding site [chemical binding]; other site
365044004493	metal binding site [ion binding]; metal-binding site
365044004494	active site
365044004495	aminopeptidase N; Provisional; Region: pepN; PRK14015
365044004496	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
365044004497	active site
365044004498	Zn binding site [ion binding]; other site
365044004499	peptide chain release factor 2; Validated; Region: prfB; PRK00578
365044004500	RF-1 domain; Region: RF-1; cl02875
365044004501	RF-1 domain; Region: RF-1; cl02875
365044004502	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004504	active site
365044004505	phosphorylation site [posttranslational modification]
365044004506	intermolecular recognition site; other site
365044004507	dimerization interface [polypeptide binding]; other site
365044004508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044004509	dimer interface [polypeptide binding]; other site
365044004510	phosphorylation site [posttranslational modification]
365044004511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004512	ATP binding site [chemical binding]; other site
365044004513	Mg2+ binding site [ion binding]; other site
365044004514	G-X-G motif; other site
365044004515	CheB methylesterase; Region: CheB_methylest; pfam01339
365044004516	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
365044004517	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
365044004518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044004519	CHASE3 domain; Region: CHASE3; cl05000
365044004520	GAF domain; Region: GAF; cl15785
365044004521	GAF domain; Region: GAF_2; pfam13185
365044004522	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
365044004523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004524	ATP binding site [chemical binding]; other site
365044004525	Mg2+ binding site [ion binding]; other site
365044004526	G-X-G motif; other site
365044004527	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004529	active site
365044004530	phosphorylation site [posttranslational modification]
365044004531	intermolecular recognition site; other site
365044004532	dimerization interface [polypeptide binding]; other site
365044004533	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004535	active site
365044004536	phosphorylation site [posttranslational modification]
365044004537	intermolecular recognition site; other site
365044004538	Response regulator receiver domain; Region: Response_reg; pfam00072
365044004539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044004540	active site
365044004541	phosphorylation site [posttranslational modification]
365044004542	intermolecular recognition site; other site
365044004543	dimerization interface [polypeptide binding]; other site
365044004544	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044004545	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044004546	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044004547	ligand binding site [chemical binding]; other site
365044004548	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
365044004549	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365044004550	active site
365044004551	catalytic tetrad [active]
365044004552	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
365044004553	putative deacylase active site [active]
365044004554	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
365044004555	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
365044004556	catalytic motif [active]
365044004557	Catalytic residue [active]
365044004558	Protein of unknown function (DUF520); Region: DUF520; cl00723
365044004559	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
365044004560	FAD binding domain; Region: FAD_binding_4; pfam01565
365044004561	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
365044004562	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
365044004563	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
365044004564	Ligand Binding Site [chemical binding]; other site
365044004565	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
365044004566	RNA polymerase sigma factor; Provisional; Region: PRK12514
365044004567	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044004568	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044004569	DNA binding residues [nucleotide binding]
365044004570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
365044004571	Anti-sigma-K factor rskA; Region: RskA; pfam10099
365044004572	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
365044004573	ArsC family; Region: ArsC; pfam03960
365044004574	putative catalytic residues [active]
365044004575	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
365044004576	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
365044004577	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044004578	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044004579	Sporulation related domain; Region: SPOR; cl10051
365044004580	Colicin V production protein; Region: Colicin_V; cl00567
365044004581	amidophosphoribosyltransferase; Provisional; Region: PRK09246
365044004582	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
365044004583	active site
365044004584	tetramer interface [polypeptide binding]; other site
365044004585	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044004586	active site
365044004587	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
365044004588	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365044004589	homodimer interface [polypeptide binding]; other site
365044004590	substrate-cofactor binding pocket; other site
365044004591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044004592	catalytic residue [active]
365044004593	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
365044004594	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
365044004595	active site
365044004596	HIGH motif; other site
365044004597	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
365044004598	active site
365044004599	KMSKS motif; other site
365044004600	SWIM zinc finger; Region: SWIM; cl15408
365044004601	SNF2 Helicase protein; Region: DUF3670; pfam12419
365044004602	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
365044004603	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044004604	ATP binding site [chemical binding]; other site
365044004605	putative Mg++ binding site [ion binding]; other site
365044004606	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044004607	nucleotide binding region [chemical binding]; other site
365044004608	ATP-binding site [chemical binding]; other site
365044004609	Ion channel; Region: Ion_trans_2; cl11596
365044004610	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
365044004611	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
365044004612	EamA-like transporter family; Region: EamA; cl01037
365044004613	EamA-like transporter family; Region: EamA; cl01037
365044004614	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
365044004615	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
365044004616	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
365044004617	DNA binding site [nucleotide binding]
365044004618	active site
365044004619	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
365044004620	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
365044004621	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044004622	AlkA N-terminal domain; Region: AlkA_N; cl05528
365044004623	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
365044004624	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044004625	minor groove reading motif; other site
365044004626	helix-hairpin-helix signature motif; other site
365044004627	substrate binding pocket [chemical binding]; other site
365044004628	active site
365044004629	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
365044004630	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
365044004631	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
365044004632	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
365044004633	active site
365044004634	catalytic site [active]
365044004635	glycogen branching enzyme; Provisional; Region: PRK05402
365044004636	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
365044004637	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
365044004638	active site
365044004639	catalytic site [active]
365044004640	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
365044004641	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
365044004642	homodimer interface [polypeptide binding]; other site
365044004643	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
365044004644	active site pocket [active]
365044004645	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
365044004646	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
365044004647	ligand binding site; other site
365044004648	oligomer interface; other site
365044004649	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
365044004650	dimer interface [polypeptide binding]; other site
365044004651	N-terminal domain interface [polypeptide binding]; other site
365044004652	sulfate 1 binding site; other site
365044004653	glycogen synthase; Provisional; Region: glgA; PRK00654
365044004654	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
365044004655	ADP-binding pocket [chemical binding]; other site
365044004656	homodimer interface [polypeptide binding]; other site
365044004657	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
365044004658	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
365044004659	active site
365044004660	substrate binding site [chemical binding]; other site
365044004661	metal binding site [ion binding]; metal-binding site
365044004662	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
365044004663	putative active site [active]
365044004664	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
365044004665	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
365044004666	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044004667	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
365044004668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044004669	NAD(P) binding site [chemical binding]; other site
365044004670	active site
365044004671	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
365044004672	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044004673	classical (c) SDRs; Region: SDR_c; cd05233
365044004674	NAD(P) binding site [chemical binding]; other site
365044004675	active site
365044004676	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
365044004677	cofactor binding site; other site
365044004678	metal binding site [ion binding]; metal-binding site
365044004679	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
365044004680	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
365044004681	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044004682	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
365044004683	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044004684	Zn binding site [ion binding]; other site
365044004685	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
365044004686	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
365044004687	dimer interface [polypeptide binding]; other site
365044004688	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
365044004689	active site
365044004690	Fe binding site [ion binding]; other site
365044004691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044004692	NMT1-like family; Region: NMT1_2; cl15260
365044004693	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044004694	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044004695	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044004696	active site
365044004697	catalytic residues [active]
365044004698	metal binding site [ion binding]; metal-binding site
365044004699	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044004700	Helix-turn-helix domains; Region: HTH; cl00088
365044004701	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
365044004702	putative dimerization interface [polypeptide binding]; other site
365044004703	tellurium resistance terB-like protein; Region: terB_like; cd07177
365044004704	metal binding site [ion binding]; metal-binding site
365044004705	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
365044004706	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044004707	active site residue [active]
365044004708	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
365044004709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004710	S-adenosylmethionine binding site [chemical binding]; other site
365044004711	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044004712	Helix-turn-helix domains; Region: HTH; cl00088
365044004713	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
365044004714	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
365044004715	active site
365044004716	tetramer interface [polypeptide binding]; other site
365044004717	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044004718	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044004719	DNA binding site [nucleotide binding]
365044004720	domain linker motif; other site
365044004721	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
365044004722	putative dimerization interface [polypeptide binding]; other site
365044004723	putative ligand binding site [chemical binding]; other site
365044004724	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
365044004725	putative active site [active]
365044004726	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
365044004727	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044004728	FAD binding site [chemical binding]; other site
365044004729	substrate binding pocket [chemical binding]; other site
365044004730	catalytic base [active]
365044004731	Helix-turn-helix domains; Region: HTH; cl00088
365044004732	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
365044004733	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448
365044004734	putative dimerization interface [polypeptide binding]; other site
365044004735	putative substrate binding pocket [chemical binding]; other site
365044004736	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
365044004737	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044004738	Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693
365044004739	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044004740	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044004741	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044004742	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535
365044004743	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004744	AAA domain; Region: AAA_21; pfam13304
365044004745	Walker A/P-loop; other site
365044004746	ATP binding site [chemical binding]; other site
365044004747	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
365044004748	Q-loop/lid; other site
365044004749	ABC transporter signature motif; other site
365044004750	Walker B; other site
365044004751	D-loop; other site
365044004752	H-loop/switch region; other site
365044004753	FOG: CBS domain [General function prediction only]; Region: COG0517
365044004754	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
365044004755	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
365044004756	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
365044004757	metal binding site [ion binding]; metal-binding site
365044004758	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
365044004759	ABC-ATPase subunit  interface; other site
365044004760	dimer interface [polypeptide binding]; other site
365044004761	putative PBP binding regions; other site
365044004762	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
365044004763	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
365044004764	Helix-turn-helix domains; Region: HTH; cl00088
365044004765	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044004766	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004767	Walker A/P-loop; other site
365044004768	ATP binding site [chemical binding]; other site
365044004769	Q-loop/lid; other site
365044004770	ABC transporter signature motif; other site
365044004771	Walker B; other site
365044004772	D-loop; other site
365044004773	H-loop/switch region; other site
365044004774	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044004775	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
365044004776	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
365044004777	Protein of unknown function, DUF486; Region: DUF486; cl01236
365044004778	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
365044004779	Phosphate transporter family; Region: PHO4; cl00396
365044004780	FtsX-like permease family; Region: FtsX; cl15850
365044004781	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044004782	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044004783	Walker A/P-loop; other site
365044004784	ATP binding site [chemical binding]; other site
365044004785	Q-loop/lid; other site
365044004786	ABC transporter signature motif; other site
365044004787	Walker B; other site
365044004788	D-loop; other site
365044004789	H-loop/switch region; other site
365044004790	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
365044004791	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004792	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044004793	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
365044004794	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
365044004795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004796	ATP binding site [chemical binding]; other site
365044004797	Mg2+ binding site [ion binding]; other site
365044004798	G-X-G motif; other site
365044004799	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
365044004800	ATP binding site [chemical binding]; other site
365044004801	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
365044004802	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
365044004803	beta-ketothiolase; Provisional; Region: PRK09051
365044004804	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044004805	dimer interface [polypeptide binding]; other site
365044004806	active site
365044004807	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
365044004808	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004809	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
365044004810	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
365044004811	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
365044004812	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044004813	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
365044004814	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
365044004815	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
365044004816	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
365044004817	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044004818	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
365044004819	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
365044004820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044004821	Walker A motif; other site
365044004822	ATP binding site [chemical binding]; other site
365044004823	Walker B motif; other site
365044004824	arginine finger; other site
365044004825	Helix-turn-helix domains; Region: HTH; cl00088
365044004826	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
365044004827	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
365044004828	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044004829	AMP-binding enzyme; Region: AMP-binding; cl15778
365044004830	AMIN domain; Region: AMIN; pfam11741
365044004831	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
365044004832	active site
365044004833	metal binding site [ion binding]; metal-binding site
365044004834	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
365044004835	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
365044004836	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
365044004837	Membrane transport protein; Region: Mem_trans; cl09117
365044004838	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
365044004839	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044004840	active site
365044004841	DNA binding site [nucleotide binding]
365044004842	Int/Topo IB signature motif; other site
365044004843	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
365044004844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044004845	S-adenosylmethionine binding site [chemical binding]; other site
365044004846	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
365044004847	dinuclear metal binding motif [ion binding]; other site
365044004848	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
365044004849	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
365044004850	trimer interface [polypeptide binding]; other site
365044004851	putative metal binding site [ion binding]; other site
365044004852	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
365044004853	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
365044004854	dimerization interface [polypeptide binding]; other site
365044004855	domain crossover interface; other site
365044004856	redox-dependent activation switch; other site
365044004857	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
365044004858	Septum formation initiator; Region: DivIC; cl11433
365044004859	enolase; Provisional; Region: eno; PRK00077
365044004860	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
365044004861	dimer interface [polypeptide binding]; other site
365044004862	metal binding site [ion binding]; metal-binding site
365044004863	substrate binding pocket [chemical binding]; other site
365044004864	NeuB family; Region: NeuB; cl00496
365044004865	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365044004866	CTP synthetase; Validated; Region: pyrG; PRK05380
365044004867	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
365044004868	Catalytic site [active]
365044004869	active site
365044004870	UTP binding site [chemical binding]; other site
365044004871	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
365044004872	active site
365044004873	putative oxyanion hole; other site
365044004874	catalytic triad [active]
365044004875	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
365044004876	Flavoprotein; Region: Flavoprotein; cl08021
365044004877	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
365044004878	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
365044004879	trimer interface [polypeptide binding]; other site
365044004880	active site
365044004881	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
365044004882	Uncharacterized conserved protein [Function unknown]; Region: COG2850
365044004883	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044004884	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
365044004885	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
365044004886	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
365044004887	dihydrodipicolinate synthase; Region: dapA; TIGR00674
365044004888	dimer interface [polypeptide binding]; other site
365044004889	active site
365044004890	catalytic residue [active]
365044004891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044004892	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044004893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044004894	putative substrate translocation pore; other site
365044004895	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
365044004896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044004897	ATP binding site [chemical binding]; other site
365044004898	Mg2+ binding site [ion binding]; other site
365044004899	G-X-G motif; other site
365044004900	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
365044004901	anchoring element; other site
365044004902	dimer interface [polypeptide binding]; other site
365044004903	ATP binding site [chemical binding]; other site
365044004904	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
365044004905	active site
365044004906	metal binding site [ion binding]; metal-binding site
365044004907	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
365044004908	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044004909	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044004910	catalytic residue [active]
365044004911	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
365044004912	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
365044004913	CAP-like domain; other site
365044004914	active site
365044004915	primary dimer interface [polypeptide binding]; other site
365044004916	Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598
365044004917	Zn binding site [ion binding]; other site
365044004918	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
365044004919	amidase catalytic site [active]
365044004920	Zn binding residues [ion binding]; other site
365044004921	substrate binding site [chemical binding]; other site
365044004922	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
365044004923	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
365044004924	homotrimer interaction site [polypeptide binding]; other site
365044004925	putative active site [active]
365044004926	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
365044004927	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
365044004928	Competence protein; Region: Competence; cl00471
365044004929	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044004930	Uncharacterized conserved protein [Function unknown]; Region: COG2308
365044004931	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
365044004932	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
365044004933	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044004934	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044004935	PhoD-like phosphatase; Region: PhoD; pfam09423
365044004936	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
365044004937	putative active site [active]
365044004938	PhoD-like phosphatase; Region: PhoD; pfam09423
365044004939	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044004940	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
365044004941	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
365044004942	NADP binding site [chemical binding]; other site
365044004943	dimer interface [polypeptide binding]; other site
365044004944	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
365044004945	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004946	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044004947	Family description; Region: UvrD_C_2; cl15862
365044004948	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044004949	putative active site [active]
365044004950	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
365044004951	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
365044004952	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044004953	oligomeric interface; other site
365044004954	putative active site [active]
365044004955	homodimer interface [polypeptide binding]; other site
365044004956	KWG Leptospira; Region: KWG; pfam07656
365044004957	KWG Leptospira; Region: KWG; pfam07656
365044004958	KWG Leptospira; Region: KWG; pfam07656
365044004959	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
365044004960	Transglycosylase SLT domain; Region: SLT_2; pfam13406
365044004961	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044004962	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044004963	catalytic residue [active]
365044004964	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
365044004965	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044004966	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
365044004967	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044004968	MoxR-like ATPases [General function prediction only]; Region: COG0714
365044004969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044004970	Walker A motif; other site
365044004971	ATP binding site [chemical binding]; other site
365044004972	Walker B motif; other site
365044004973	arginine finger; other site
365044004974	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
365044004975	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
365044004976	enoyl-CoA hydratase; Validated; Region: PRK08139
365044004977	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044004978	substrate binding site [chemical binding]; other site
365044004979	oxyanion hole (OAH) forming residues; other site
365044004980	trimer interface [polypeptide binding]; other site
365044004981	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
365044004982	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365044004983	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
365044004984	Ligand binding site [chemical binding]; other site
365044004985	Electron transfer flavoprotein domain; Region: ETF; pfam01012
365044004986	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
365044004987	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
365044004988	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
365044004989	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
365044004990	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
365044004991	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044004992	active site
365044004993	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
365044004994	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
365044004995	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365044004996	FMN binding site [chemical binding]; other site
365044004997	substrate binding site [chemical binding]; other site
365044004998	putative catalytic residue [active]
365044004999	putative metal dependent hydrolase; Provisional; Region: PRK11598
365044005000	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
365044005001	Sulfatase; Region: Sulfatase; cl10460
365044005002	Predicted esterase [General function prediction only]; Region: COG0627
365044005003	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044005004	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
365044005005	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
365044005006	substrate binding site [chemical binding]; other site
365044005007	catalytic Zn binding site [ion binding]; other site
365044005008	NAD binding site [chemical binding]; other site
365044005009	structural Zn binding site [ion binding]; other site
365044005010	dimer interface [polypeptide binding]; other site
365044005011	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044005012	RNA binding surface [nucleotide binding]; other site
365044005013	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
365044005014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044005015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
365044005016	dimer interface [polypeptide binding]; other site
365044005017	phosphorylation site [posttranslational modification]
365044005018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044005019	ATP binding site [chemical binding]; other site
365044005020	Mg2+ binding site [ion binding]; other site
365044005021	G-X-G motif; other site
365044005022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044005023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044005024	active site
365044005025	phosphorylation site [posttranslational modification]
365044005026	intermolecular recognition site; other site
365044005027	dimerization interface [polypeptide binding]; other site
365044005028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044005029	DNA binding site [nucleotide binding]
365044005030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044005031	NMT1-like family; Region: NMT1_2; cl15260
365044005032	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
365044005033	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
365044005034	NMT1-like family; Region: NMT1_2; cl15260
365044005035	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
365044005036	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044005037	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
365044005038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044005039	Integrase core domain; Region: rve; cl01316
365044005040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044005041	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
365044005042	classical (c) SDRs; Region: SDR_c; cd05233
365044005043	NAD(P) binding site [chemical binding]; other site
365044005044	active site
365044005045	UbiA prenyltransferase family; Region: UbiA; cl00337
365044005046	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044005047	octamerization interface [polypeptide binding]; other site
365044005048	diferric-oxygen binding site [ion binding]; other site
365044005049	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
365044005050	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044005051	ATP binding site [chemical binding]; other site
365044005052	Mg++ binding site [ion binding]; other site
365044005053	motif III; other site
365044005054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044005055	nucleotide binding region [chemical binding]; other site
365044005056	ATP-binding site [chemical binding]; other site
365044005057	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
365044005058	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044005059	Walker A/P-loop; other site
365044005060	ATP binding site [chemical binding]; other site
365044005061	Q-loop/lid; other site
365044005062	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
365044005063	ABC transporter signature motif; other site
365044005064	Walker B; other site
365044005065	D-loop; other site
365044005066	ABC transporter; Region: ABC_tran_2; pfam12848
365044005067	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
365044005068	Protein of unknown function (DUF1415); Region: DUF1415; cl01301
365044005069	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
365044005070	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
365044005071	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
365044005072	metal binding site [ion binding]; metal-binding site
365044005073	putative dimer interface [polypeptide binding]; other site
365044005074	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
365044005075	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
365044005076	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044005077	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
365044005078	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044005079	motif II; other site
365044005080	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365044005081	NMT1-like family; Region: NMT1_2; cl15260
365044005082	NMT1/THI5 like; Region: NMT1; pfam09084
365044005083	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
365044005084	Phospholipid methyltransferase; Region: PEMT; cl00763
365044005085	Fe2+ transport protein; Region: Iron_transport; cl01377
365044005086	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
365044005087	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044005088	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044005089	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044005090	motif II; other site
365044005091	Protein of unknown function, DUF; Region: DUF411; cl01142
365044005092	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044005093	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
365044005094	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044005095	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044005096	Herpesvirus UL21; Region: Herpes_UL21; pfam03252
365044005097	Ion transport protein; Region: Ion_trans; pfam00520
365044005098	Ion channel; Region: Ion_trans_2; cl11596
365044005099	YaeQ protein; Region: YaeQ; cl01913
365044005100	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
365044005101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044005102	FeS/SAM binding site; other site
365044005103	HemN C-terminal domain; Region: HemN_C; pfam06969
365044005104	Domain of unknown function (DUF427); Region: DUF427; cl00998
365044005105	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044005106	Ligand Binding Site [chemical binding]; other site
365044005107	Protein of unknown function (DUF465); Region: DUF465; cl01070
365044005108	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
365044005109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005110	short chain dehydrogenase; Provisional; Region: PRK07023
365044005111	NAD(P) binding site [chemical binding]; other site
365044005112	active site
365044005113	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365044005114	active site
365044005115	Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894
365044005116	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044005117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044005118	Probable transposase; Region: OrfB_IS605; pfam01385
365044005119	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044005120	Transposase IS200 like; Region: Y1_Tnp; cl00848
365044005121	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
365044005122	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044005123	H+ Antiporter protein; Region: 2A0121; TIGR00900
365044005124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005125	putative substrate translocation pore; other site
365044005126	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044005127	Cytochrome c; Region: Cytochrom_C; cl11414
365044005128	Cytochrome c; Region: Cytochrom_C; cl11414
365044005129	Cytochrome c; Region: Cytochrom_C; cl11414
365044005130	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044005131	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044005132	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
365044005133	putative active site [active]
365044005134	Zn binding site [ion binding]; other site
365044005135	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044005136	catalytic loop [active]
365044005137	iron binding site [ion binding]; other site
365044005138	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
365044005139	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044005140	Coenzyme A binding pocket [chemical binding]; other site
365044005141	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
365044005142	Protein of unknown function (DUF808); Region: DUF808; cl01002
365044005143	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
365044005144	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005145	NAD(P) binding site [chemical binding]; other site
365044005146	active site
365044005147	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365044005148	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
365044005149	putative NAD(P) binding site [chemical binding]; other site
365044005150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005151	short chain dehydrogenase; Provisional; Region: PRK06179
365044005152	Helix-turn-helix domains; Region: HTH; cl00088
365044005153	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044005154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044005155	Probable transposase; Region: OrfB_IS605; pfam01385
365044005156	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044005157	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044005158	Helix-turn-helix domains; Region: HTH; cl00088
365044005159	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
365044005160	putative effector binding pocket; other site
365044005161	putative dimerization interface [polypeptide binding]; other site
365044005162	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
365044005163	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044005164	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
365044005165	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044005166	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
365044005167	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044005168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044005169	S-adenosylmethionine binding site [chemical binding]; other site
365044005170	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
365044005171	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365044005172	FMN binding site [chemical binding]; other site
365044005173	active site
365044005174	catalytic residues [active]
365044005175	substrate binding site [chemical binding]; other site
365044005176	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
365044005177	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
365044005178	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
365044005179	heme-binding site [chemical binding]; other site
365044005180	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
365044005181	FAD binding pocket [chemical binding]; other site
365044005182	FAD binding motif [chemical binding]; other site
365044005183	phosphate binding motif [ion binding]; other site
365044005184	beta-alpha-beta structure motif; other site
365044005185	NAD binding pocket [chemical binding]; other site
365044005186	Heme binding  pocket [chemical binding]; other site
365044005187	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
365044005188	GAF domain; Region: GAF; cl15785
365044005189	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044005190	Walker A motif; other site
365044005191	ATP binding site [chemical binding]; other site
365044005192	Walker B motif; other site
365044005193	arginine finger; other site
365044005194	Helix-turn-helix domains; Region: HTH; cl00088
365044005195	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044005196	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
365044005197	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
365044005198	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
365044005199	Phosphate-starvation-inducible E; Region: PsiE; cl01264
365044005200	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
365044005201	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
365044005202	GTP/Mg2+ binding site [chemical binding]; other site
365044005203	G4 box; other site
365044005204	G5 box; other site
365044005205	G1 box; other site
365044005206	Switch I region; other site
365044005207	G2 box; other site
365044005208	G3 box; other site
365044005209	Switch II region; other site
365044005210	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044005211	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044005212	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044005213	ligand binding site [chemical binding]; other site
365044005214	flexible hinge region; other site
365044005215	Helix-turn-helix domains; Region: HTH; cl00088
365044005216	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044005217	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
365044005218	ligand binding site [chemical binding]; other site
365044005219	flexible hinge region; other site
365044005220	Helix-turn-helix domains; Region: HTH; cl00088
365044005221	Bacterial Ig-like domain; Region: Big_5; cl01012
365044005222	Bacterial Ig-like domain; Region: Big_5; cl01012
365044005223	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
365044005224	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044005225	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044005226	ligand binding site [chemical binding]; other site
365044005227	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044005228	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
365044005229	putative dimer interface [polypeptide binding]; other site
365044005230	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
365044005231	putative dimer interface [polypeptide binding]; other site
365044005232	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
365044005233	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044005234	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
365044005235	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044005236	Helix-turn-helix domains; Region: HTH; cl00088
365044005237	Rrf2 family protein; Region: rrf2_super; TIGR00738
365044005238	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
365044005239	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
365044005240	Binuclear center (active site) [active]
365044005241	K-pathway; other site
365044005242	Putative proton exit pathway; other site
365044005243	Putative water exit pathway; other site
365044005244	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
365044005245	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
365044005246	thioredoxin 2; Provisional; Region: PRK10996
365044005247	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044005248	catalytic residues [active]
365044005249	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044005250	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
365044005251	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044005252	pseudouridine synthase; Region: TIGR00093
365044005253	active site
365044005254	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
365044005255	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
365044005256	active site
365044005257	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044005258	Isochorismatase family; Region: Isochorismatase; pfam00857
365044005259	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
365044005260	catalytic triad [active]
365044005261	dimer interface [polypeptide binding]; other site
365044005262	conserved cis-peptide bond; other site
365044005263	Helix-turn-helix domains; Region: HTH; cl00088
365044005264	transcriptional activator TtdR; Provisional; Region: PRK09801
365044005265	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044005266	putative effector binding pocket; other site
365044005267	dimerization interface [polypeptide binding]; other site
365044005268	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
365044005269	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044005270	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
365044005271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005272	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
365044005273	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365044005274	active site
365044005275	NTP binding site [chemical binding]; other site
365044005276	metal binding triad [ion binding]; metal-binding site
365044005277	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
365044005278	DNA-binding site [nucleotide binding]; DNA binding site
365044005279	RNA-binding motif; other site
365044005280	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
365044005281	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
365044005282	putative active site [active]
365044005283	putative NTP binding site [chemical binding]; other site
365044005284	putative nucleic acid binding site [nucleotide binding]; other site
365044005285	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
365044005286	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
365044005287	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
365044005288	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044005289	active site
365044005290	HIGH motif; other site
365044005291	nucleotide binding site [chemical binding]; other site
365044005292	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
365044005293	KMSKS motif; other site
365044005294	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
365044005295	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
365044005296	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044005297	trimer interface [polypeptide binding]; other site
365044005298	eyelet of channel; other site
365044005299	Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
365044005300	Bacitracin resistance protein BacA; Region: BacA; cl00858
365044005301	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044005302	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
365044005303	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
365044005304	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
365044005305	MutS domain I; Region: MutS_I; pfam01624
365044005306	MutS domain II; Region: MutS_II; pfam05188
365044005307	MutS family domain IV; Region: MutS_IV; pfam05190
365044005308	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044005309	Walker A/P-loop; other site
365044005310	ATP binding site [chemical binding]; other site
365044005311	Q-loop/lid; other site
365044005312	ABC transporter signature motif; other site
365044005313	Walker B; other site
365044005314	D-loop; other site
365044005315	H-loop/switch region; other site
365044005316	EamA-like transporter family; Region: EamA; cl01037
365044005317	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044005318	EamA-like transporter family; Region: EamA; cl01037
365044005319	transcriptional regulator; Provisional; Region: PRK10632
365044005320	Helix-turn-helix domains; Region: HTH; cl00088
365044005321	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044005322	putative effector binding pocket; other site
365044005323	dimerization interface [polypeptide binding]; other site
365044005324	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
365044005325	Fusaric acid resistance protein family; Region: FUSC; pfam04632
365044005326	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
365044005327	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044005328	putative acyl-acceptor binding pocket; other site
365044005329	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
365044005330	Ligand binding site; other site
365044005331	Putative Catalytic site; other site
365044005332	DXD motif; other site
365044005333	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044005334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005335	NAD(P) binding site [chemical binding]; other site
365044005336	active site
365044005337	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
365044005338	putative active site 1 [active]
365044005339	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
365044005340	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
365044005341	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365044005342	dimer interface [polypeptide binding]; other site
365044005343	active site
365044005344	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
365044005345	active site
365044005346	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
365044005347	NodB motif; other site
365044005348	active site
365044005349	catalytic site [active]
365044005350	metal binding site [ion binding]; metal-binding site
365044005351	Predicted exporter [General function prediction only]; Region: COG4258
365044005352	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
365044005353	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
365044005354	putative acyl-acceptor binding pocket; other site
365044005355	Predicted membrane protein [Function unknown]; Region: COG4648
365044005356	Phosphopantetheine attachment site; Region: PP-binding; cl09936
365044005357	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
365044005358	active site
365044005359	dimerization interface [polypeptide binding]; other site
365044005360	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
365044005361	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
365044005362	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
365044005363	serine O-acetyltransferase; Region: cysE; TIGR01172
365044005364	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365044005365	trimer interface [polypeptide binding]; other site
365044005366	active site
365044005367	substrate binding site [chemical binding]; other site
365044005368	CoA binding site [chemical binding]; other site
365044005369	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
365044005370	MPT binding site; other site
365044005371	trimer interface [polypeptide binding]; other site
365044005372	Protein of unknown function (DUF615); Region: DUF615; cl01147
365044005373	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
365044005374	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
365044005375	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
365044005376	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
365044005377	GatB domain; Region: GatB_Yqey; cl11497
365044005378	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
365044005379	HI0933-like protein; Region: HI0933_like; pfam03486
365044005380	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
365044005381	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
365044005382	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
365044005383	Helix-turn-helix domains; Region: HTH; cl00088
365044005384	Winged helix-turn helix; Region: HTH_29; pfam13551
365044005385	Winged helix-turn helix; Region: HTH_33; pfam13592
365044005386	Integrase core domain; Region: rve; cl01316
365044005387	Transposase domain (DUF772); Region: DUF772; pfam05598
365044005388	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044005389	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044005390	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044005391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044005392	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044005393	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044005394	Predicted transcriptional regulator [Transcription]; Region: COG2378
365044005395	WYL domain; Region: WYL; cl14852
365044005396	HI0933-like protein; Region: HI0933_like; pfam03486
365044005397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005399	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044005400	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044005401	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
365044005402	glycosyl transferase family protein; Provisional; Region: PRK08136
365044005403	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
365044005404	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
365044005405	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
365044005406	[4Fe-4S] binding site [ion binding]; other site
365044005407	molybdopterin cofactor binding site; other site
365044005408	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
365044005409	molybdopterin cofactor binding site; other site
365044005410	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
365044005411	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
365044005412	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
365044005413	[2Fe-2S] cluster binding site [ion binding]; other site
365044005414	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044005415	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044005416	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
365044005417	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044005418	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
365044005419	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
365044005420	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
365044005421	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
365044005422	FOG: CBS domain [General function prediction only]; Region: COG0517
365044005423	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044005424	Protein phosphatase 2C; Region: PP2C; pfam00481
365044005425	active site
365044005426	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044005427	active site
365044005428	ATP binding site [chemical binding]; other site
365044005429	substrate binding site [chemical binding]; other site
365044005430	activation loop (A-loop); other site
365044005431	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
365044005432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005433	putative substrate translocation pore; other site
365044005434	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
365044005435	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
365044005436	Walker A/P-loop; other site
365044005437	ATP binding site [chemical binding]; other site
365044005438	Q-loop/lid; other site
365044005439	ABC transporter signature motif; other site
365044005440	Walker B; other site
365044005441	D-loop; other site
365044005442	H-loop/switch region; other site
365044005443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005444	dimer interface [polypeptide binding]; other site
365044005445	conserved gate region; other site
365044005446	putative PBP binding loops; other site
365044005447	ABC-ATPase subunit interface; other site
365044005448	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
365044005449	NMT1-like family; Region: NMT1_2; cl15260
365044005450	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
365044005451	ANTAR domain; Region: ANTAR; cl04297
365044005452	UGMP family protein; Validated; Region: PRK09604
365044005453	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
365044005454	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
365044005455	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044005456	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
365044005457	putative ligand binding site [chemical binding]; other site
365044005458	aspartate aminotransferase; Provisional; Region: PRK06108
365044005459	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044005460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044005461	homodimer interface [polypeptide binding]; other site
365044005462	catalytic residue [active]
365044005463	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
365044005464	16S/18S rRNA binding site [nucleotide binding]; other site
365044005465	S13e-L30e interaction site [polypeptide binding]; other site
365044005466	25S rRNA binding site [nucleotide binding]; other site
365044005467	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
365044005468	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
365044005469	RNase E interface [polypeptide binding]; other site
365044005470	trimer interface [polypeptide binding]; other site
365044005471	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
365044005472	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
365044005473	RNase E interface [polypeptide binding]; other site
365044005474	trimer interface [polypeptide binding]; other site
365044005475	active site
365044005476	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
365044005477	putative nucleic acid binding region [nucleotide binding]; other site
365044005478	G-X-X-G motif; other site
365044005479	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
365044005480	RNA binding site [nucleotide binding]; other site
365044005481	domain interface; other site
365044005482	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
365044005483	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
365044005484	NAD(P) binding site [chemical binding]; other site
365044005485	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
365044005486	dimer interface [polypeptide binding]; other site
365044005487	substrate binding site [chemical binding]; other site
365044005488	catalytic triad [active]
365044005489	Preprotein translocase SecG subunit; Region: SecG; cl09123
365044005490	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
365044005491	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
365044005492	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
365044005493	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
365044005494	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
365044005495	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
365044005496	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
365044005497	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
365044005498	putative dimer interface [polypeptide binding]; other site
365044005499	[2Fe-2S] cluster binding site [ion binding]; other site
365044005500	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
365044005501	SLBB domain; Region: SLBB; pfam10531
365044005502	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
365044005503	NADH dehydrogenase subunit G; Validated; Region: PRK09129
365044005504	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044005505	catalytic loop [active]
365044005506	iron binding site [ion binding]; other site
365044005507	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
365044005508	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
365044005509	NADH dehydrogenase; Region: NADHdh; cl00469
365044005510	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
365044005511	4Fe-4S binding domain; Region: Fer4; cl02805
365044005512	4Fe-4S binding domain; Region: Fer4; cl02805
365044005513	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
365044005514	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
365044005515	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
365044005516	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
365044005517	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
365044005518	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
365044005519	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
365044005520	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
365044005521	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
365044005522	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
365044005523	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
365044005524	dimer interface [polypeptide binding]; other site
365044005525	ADP-ribose binding site [chemical binding]; other site
365044005526	active site
365044005527	nudix motif; other site
365044005528	metal binding site [ion binding]; metal-binding site
365044005529	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
365044005530	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
365044005531	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
365044005532	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
365044005533	NAD(P) binding site [chemical binding]; other site
365044005534	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
365044005535	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044005536	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
365044005537	Walker A/P-loop; other site
365044005538	ATP binding site [chemical binding]; other site
365044005539	Q-loop/lid; other site
365044005540	ABC transporter signature motif; other site
365044005541	Walker B; other site
365044005542	D-loop; other site
365044005543	H-loop/switch region; other site
365044005544	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044005545	Helix-turn-helix domains; Region: HTH; cl00088
365044005546	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044005547	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
365044005548	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044005549	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044005550	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
365044005551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044005552	putative substrate translocation pore; other site
365044005553	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
365044005554	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
365044005555	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
365044005556	DNA binding residues [nucleotide binding]
365044005557	B12 binding domain; Region: B12-binding_2; cl03653
365044005558	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
365044005559	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
365044005560	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005561	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
365044005562	Uncharacterized conserved protein [Function unknown]; Region: COG3496
365044005563	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
365044005564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044005565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044005566	S-adenosylmethionine binding site [chemical binding]; other site
365044005567	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
365044005568	MFS/sugar transport protein; Region: MFS_2; pfam13347
365044005569	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
365044005570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005571	short chain dehydrogenase; Provisional; Region: PRK06101
365044005572	NAD(P) binding site [chemical binding]; other site
365044005573	active site
365044005574	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044005575	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
365044005576	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
365044005577	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
365044005578	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044005579	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
365044005580	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
365044005581	RimM N-terminal domain; Region: RimM; pfam01782
365044005582	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
365044005583	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
365044005584	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
365044005585	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
365044005586	putative active site [active]
365044005587	putative CoA binding site [chemical binding]; other site
365044005588	nudix motif; other site
365044005589	metal binding site [ion binding]; metal-binding site
365044005590	CobD/Cbib protein; Region: CobD_Cbib; cl00561
365044005591	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
365044005592	GTPase RsgA; Reviewed; Region: PRK00098
365044005593	RNA binding site [nucleotide binding]; other site
365044005594	homodimer interface [polypeptide binding]; other site
365044005595	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
365044005596	GTPase/Zn-binding domain interface [polypeptide binding]; other site
365044005597	GTP/Mg2+ binding site [chemical binding]; other site
365044005598	G4 box; other site
365044005599	G5 box; other site
365044005600	G1 box; other site
365044005601	Switch I region; other site
365044005602	G2 box; other site
365044005603	G3 box; other site
365044005604	Switch II region; other site
365044005605	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
365044005606	aromatic arch; other site
365044005607	DCoH dimer interaction site [polypeptide binding]; other site
365044005608	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
365044005609	DCoH tetramer interaction site [polypeptide binding]; other site
365044005610	substrate binding site [chemical binding]; other site
365044005611	Peptidase family M48; Region: Peptidase_M48; cl12018
365044005612	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
365044005613	catalytic site [active]
365044005614	putative active site [active]
365044005615	putative substrate binding site [chemical binding]; other site
365044005616	dimer interface [polypeptide binding]; other site
365044005617	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044005618	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044005619	ATP binding site [chemical binding]; other site
365044005620	Mg++ binding site [ion binding]; other site
365044005621	motif III; other site
365044005622	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044005623	nucleotide binding region [chemical binding]; other site
365044005624	ATP-binding site [chemical binding]; other site
365044005625	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
365044005626	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
365044005627	active site
365044005628	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
365044005629	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044005630	Family description; Region: UvrD_C_2; cl15862
365044005631	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
365044005632	Phosphotransferase enzyme family; Region: APH; pfam01636
365044005633	putative active site [active]
365044005634	putative substrate binding site [chemical binding]; other site
365044005635	ATP binding site [chemical binding]; other site
365044005636	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
365044005637	DNA polymerase I; Provisional; Region: PRK05755
365044005638	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
365044005639	active site
365044005640	metal binding site 1 [ion binding]; metal-binding site
365044005641	putative 5' ssDNA interaction site; other site
365044005642	metal binding site 3; metal-binding site
365044005643	metal binding site 2 [ion binding]; metal-binding site
365044005644	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
365044005645	putative DNA binding site [nucleotide binding]; other site
365044005646	putative metal binding site [ion binding]; other site
365044005647	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
365044005648	active site
365044005649	catalytic site [active]
365044005650	substrate binding site [chemical binding]; other site
365044005651	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
365044005652	active site
365044005653	DNA binding site [nucleotide binding]
365044005654	catalytic site [active]
365044005655	Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335
365044005656	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
365044005657	putative NAD(P) binding site [chemical binding]; other site
365044005658	active site
365044005659	Protein of unknown function, DUF393; Region: DUF393; cl01136
365044005660	Predicted transcriptional regulators [Transcription]; Region: COG1510
365044005661	Helix-turn-helix domains; Region: HTH; cl00088
365044005662	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
365044005663	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
365044005664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005665	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044005666	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
365044005667	substrate binding site [chemical binding]; other site
365044005668	ATP binding site [chemical binding]; other site
365044005669	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
365044005670	Glycine reductase complex selenoprotein A; Region: GRDA; cl04705
365044005671	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044005672	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
365044005673	Walker A/P-loop; other site
365044005674	ATP binding site [chemical binding]; other site
365044005675	Q-loop/lid; other site
365044005676	ABC transporter signature motif; other site
365044005677	Walker B; other site
365044005678	D-loop; other site
365044005679	H-loop/switch region; other site
365044005680	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044005681	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044005682	substrate binding pocket [chemical binding]; other site
365044005683	membrane-bound complex binding site; other site
365044005684	hinge residues; other site
365044005685	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044005686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005687	dimer interface [polypeptide binding]; other site
365044005688	conserved gate region; other site
365044005689	putative PBP binding loops; other site
365044005690	ABC-ATPase subunit interface; other site
365044005691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005692	dimer interface [polypeptide binding]; other site
365044005693	conserved gate region; other site
365044005694	ABC-ATPase subunit interface; other site
365044005695	Transcriptional regulators [Transcription]; Region: PurR; COG1609
365044005696	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
365044005697	DNA binding site [nucleotide binding]
365044005698	domain linker motif; other site
365044005699	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
365044005700	putative dimerization interface [polypeptide binding]; other site
365044005701	putative ligand binding site [chemical binding]; other site
365044005702	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
365044005703	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
365044005704	active site residue [active]
365044005705	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
365044005706	active site residue [active]
365044005707	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044005708	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
365044005709	[2Fe-2S] cluster binding site [ion binding]; other site
365044005710	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
365044005711	alpha subunit interface [polypeptide binding]; other site
365044005712	active site
365044005713	substrate binding site [chemical binding]; other site
365044005714	Fe binding site [ion binding]; other site
365044005715	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
365044005716	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
365044005717	substrate binding pocket [chemical binding]; other site
365044005718	chain length determination region; other site
365044005719	substrate-Mg2+ binding site; other site
365044005720	catalytic residues [active]
365044005721	aspartate-rich region 1; other site
365044005722	active site lid residues [active]
365044005723	aspartate-rich region 2; other site
365044005724	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
365044005725	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
365044005726	TPP-binding site; other site
365044005727	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044005728	PYR/PP interface [polypeptide binding]; other site
365044005729	dimer interface [polypeptide binding]; other site
365044005730	TPP binding site [chemical binding]; other site
365044005731	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044005732	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
365044005733	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044005734	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
365044005735	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
365044005736	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
365044005737	selenophosphate synthetase; Provisional; Region: PRK00943
365044005738	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
365044005739	dimerization interface [polypeptide binding]; other site
365044005740	putative ATP binding site [chemical binding]; other site
365044005741	TIGR03440 family protein; Region: unchr_TIGR03440
365044005742	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
365044005743	Helix-turn-helix domains; Region: HTH; cl00088
365044005744	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044005745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044005746	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044005747	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
365044005748	Walker A/P-loop; other site
365044005749	ATP binding site [chemical binding]; other site
365044005750	Q-loop/lid; other site
365044005751	ABC transporter signature motif; other site
365044005752	Walker B; other site
365044005753	D-loop; other site
365044005754	H-loop/switch region; other site
365044005755	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
365044005756	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044005757	dimerization interface [polypeptide binding]; other site
365044005758	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
365044005759	Protein of unknown function (DUF461); Region: DUF461; cl01071
365044005760	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044005761	CrcB-like protein; Region: CRCB; cl09114
365044005762	5-oxoprolinase; Region: PLN02666
365044005763	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
365044005764	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
365044005765	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
365044005766	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
365044005767	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
365044005768	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
365044005769	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
365044005770	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
365044005771	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
365044005772	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
365044005773	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
365044005774	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
365044005775	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
365044005776	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
365044005777	chaperone protein DnaJ; Provisional; Region: PRK10767
365044005778	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044005779	HSP70 interaction site [polypeptide binding]; other site
365044005780	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
365044005781	Zn binding sites [ion binding]; other site
365044005782	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
365044005783	dimer interface [polypeptide binding]; other site
365044005784	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
365044005785	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
365044005786	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
365044005787	dimer interface [polypeptide binding]; other site
365044005788	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
365044005789	Helix-turn-helix domains; Region: HTH; cl00088
365044005790	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
365044005791	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
365044005792	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365044005793	Cation efflux family; Region: Cation_efflux; cl00316
365044005794	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
365044005795	Dihaem cytochrome c; Region: DHC; pfam09626
365044005796	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044005797	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
365044005798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044005799	active site
365044005800	phosphorylation site [posttranslational modification]
365044005801	intermolecular recognition site; other site
365044005802	dimerization interface [polypeptide binding]; other site
365044005803	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044005804	DNA binding site [nucleotide binding]
365044005805	sensor protein QseC; Provisional; Region: PRK10337
365044005806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044005807	dimer interface [polypeptide binding]; other site
365044005808	phosphorylation site [posttranslational modification]
365044005809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044005810	ATP binding site [chemical binding]; other site
365044005811	Mg2+ binding site [ion binding]; other site
365044005812	G-X-G motif; other site
365044005813	CCC1-related family of proteins; Region: CCC1_like; cl00278
365044005814	CCC1-related family of proteins; Region: CCC1_like; cl00278
365044005815	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365044005816	FMN binding site [chemical binding]; other site
365044005817	substrate binding site [chemical binding]; other site
365044005818	putative catalytic residue [active]
365044005819	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044005820	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044005821	LysR family transcriptional regulator; Provisional; Region: PRK14997
365044005822	Helix-turn-helix domains; Region: HTH; cl00088
365044005823	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
365044005824	putative effector binding pocket; other site
365044005825	putative dimerization interface [polypeptide binding]; other site
365044005826	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044005827	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044005828	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044005829	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044005830	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
365044005831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005832	dimer interface [polypeptide binding]; other site
365044005833	conserved gate region; other site
365044005834	putative PBP binding loops; other site
365044005835	ABC-ATPase subunit interface; other site
365044005836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044005837	dimer interface [polypeptide binding]; other site
365044005838	conserved gate region; other site
365044005839	putative PBP binding loops; other site
365044005840	ABC-ATPase subunit interface; other site
365044005841	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
365044005842	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
365044005843	Walker A/P-loop; other site
365044005844	ATP binding site [chemical binding]; other site
365044005845	Q-loop/lid; other site
365044005846	ABC transporter signature motif; other site
365044005847	Walker B; other site
365044005848	D-loop; other site
365044005849	H-loop/switch region; other site
365044005850	TOBE-like domain; Region: TOBE_3; pfam12857
365044005851	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
365044005852	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
365044005853	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044005854	active site
365044005855	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044005856	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044005857	Helix-turn-helix domains; Region: HTH; cl00088
365044005858	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
365044005859	substrate binding pocket [chemical binding]; other site
365044005860	dimerization interface [polypeptide binding]; other site
365044005861	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044005862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005863	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044005864	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044005865	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044005866	active site
365044005867	metal binding site [ion binding]; metal-binding site
365044005868	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
365044005869	active site
365044005870	catalytic site [active]
365044005871	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044005872	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044005873	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
365044005874	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044005875	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044005876	shikimate binding site; other site
365044005877	NAD(P) binding site [chemical binding]; other site
365044005878	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
365044005879	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
365044005880	DctM-like transporters; Region: DctM; pfam06808
365044005881	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044005882	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044005883	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
365044005884	trimer interface [polypeptide binding]; other site
365044005885	active site
365044005886	dimer interface [polypeptide binding]; other site
365044005887	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
365044005888	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
365044005889	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
365044005890	dimer interface [polypeptide binding]; other site
365044005891	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
365044005892	active site
365044005893	Fe binding site [ion binding]; other site
365044005894	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
365044005895	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044005896	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044005897	shikimate binding site; other site
365044005898	NAD(P) binding site [chemical binding]; other site
365044005899	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
365044005900	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044005901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044005902	homodimer interface [polypeptide binding]; other site
365044005903	catalytic residue [active]
365044005904	excinuclease ABC subunit B; Provisional; Region: PRK05298
365044005905	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044005906	ATP binding site [chemical binding]; other site
365044005907	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044005908	nucleotide binding region [chemical binding]; other site
365044005909	ATP-binding site [chemical binding]; other site
365044005910	Ultra-violet resistance protein B; Region: UvrB; pfam12344
365044005911	UvrB/uvrC motif; Region: UVR; pfam02151
365044005912	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044005913	catalytic loop [active]
365044005914	iron binding site [ion binding]; other site
365044005915	chaperone protein HscA; Provisional; Region: hscA; PRK05183
365044005916	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044005917	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044005918	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
365044005919	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
365044005920	trimerization site [polypeptide binding]; other site
365044005921	active site
365044005922	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044005923	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
365044005924	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044005925	catalytic residue [active]
365044005926	Nif-specific regulatory protein; Region: nifA; TIGR01817
365044005927	GAF domain; Region: GAF; cl15785
365044005928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044005929	Walker A motif; other site
365044005930	ATP binding site [chemical binding]; other site
365044005931	Walker B motif; other site
365044005932	arginine finger; other site
365044005933	Helix-turn-helix domains; Region: HTH; cl00088
365044005934	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044005935	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
365044005936	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
365044005937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044005938	FeS/SAM binding site; other site
365044005939	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
365044005940	hypothetical protein; Provisional; Region: PRK13795
365044005941	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044005942	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
365044005943	NifZ domain; Region: NifZ; pfam04319
365044005944	NifZ domain; Region: NifZ; pfam04319
365044005945	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
365044005946	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
365044005947	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044005948	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044005949	catalytic residue [active]
365044005950	NifT/FixU protein; Region: NifT; cl02351
365044005951	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
365044005952	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365044005953	inhibitor-cofactor binding pocket; inhibition site
365044005954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044005955	catalytic residue [active]
365044005956	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
365044005957	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044005958	catalytic loop [active]
365044005959	iron binding site [ion binding]; other site
365044005960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005962	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
365044005963	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
365044005964	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
365044005965	Transcriptional regulators [Transcription]; Region: FadR; COG2186
365044005966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044005967	DNA-binding site [nucleotide binding]; DNA binding site
365044005968	FCD domain; Region: FCD; cl11656
365044005969	extended (e) SDRs; Region: SDR_e; cd08946
365044005970	NAD(P) binding site [chemical binding]; other site
365044005971	active site
365044005972	substrate binding site [chemical binding]; other site
365044005973	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
365044005974	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044005975	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044005976	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
365044005977	DctM-like transporters; Region: DctM; pfam06808
365044005978	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
365044005979	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
365044005980	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365044005981	putative active site [active]
365044005982	catalytic residue [active]
365044005983	galactarate dehydratase; Region: galactar-dH20; TIGR03248
365044005984	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
365044005985	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
365044005986	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
365044005987	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044005988	NAD(P) binding site [chemical binding]; other site
365044005989	catalytic residues [active]
365044005990	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044005991	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
365044005992	tartronate semialdehyde reductase; Provisional; Region: PRK15059
365044005993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044005994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044005995	NMT1-like family; Region: NMT1_2; cl15260
365044005996	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044005997	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044005998	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
365044005999	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
365044006000	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
365044006001	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
365044006002	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
365044006003	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044006004	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
365044006005	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044006006	DNA binding residues [nucleotide binding]
365044006007	DNA primase, catalytic core; Region: dnaG; TIGR01391
365044006008	CHC2 zinc finger; Region: zf-CHC2; cl15369
365044006009	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
365044006010	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
365044006011	active site
365044006012	metal binding site [ion binding]; metal-binding site
365044006013	interdomain interaction site; other site
365044006014	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
365044006015	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
365044006016	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
365044006017	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
365044006018	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044006019	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
365044006020	NAD binding site [chemical binding]; other site
365044006021	homodimer interface [polypeptide binding]; other site
365044006022	homotetramer interface [polypeptide binding]; other site
365044006023	active site
365044006024	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044006025	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
365044006026	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
365044006027	nucleophile elbow; other site
365044006028	Phasin protein; Region: Phasin_2; cl11491
365044006029	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
365044006030	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044006031	active site
365044006032	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
365044006033	putative FMN binding site [chemical binding]; other site
365044006034	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044006035	TM-ABC transporter signature motif; other site
365044006036	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044006037	TM-ABC transporter signature motif; other site
365044006038	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044006039	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044006040	Walker A/P-loop; other site
365044006041	ATP binding site [chemical binding]; other site
365044006042	Q-loop/lid; other site
365044006043	ABC transporter signature motif; other site
365044006044	Walker B; other site
365044006045	D-loop; other site
365044006046	H-loop/switch region; other site
365044006047	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044006048	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044006049	Walker A/P-loop; other site
365044006050	ATP binding site [chemical binding]; other site
365044006051	Q-loop/lid; other site
365044006052	ABC transporter signature motif; other site
365044006053	Walker B; other site
365044006054	D-loop; other site
365044006055	H-loop/switch region; other site
365044006056	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
365044006057	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
365044006058	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
365044006059	active site
365044006060	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
365044006061	transmembrane helices; other site
365044006062	glyoxylate reductase; Reviewed; Region: PRK13243
365044006063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006064	RmuC family; Region: RmuC; pfam02646
365044006065	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
365044006066	elongation factor P; Validated; Region: PRK00529
365044006067	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
365044006068	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
365044006069	RNA binding site [nucleotide binding]; other site
365044006070	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
365044006071	RNA binding site [nucleotide binding]; other site
365044006072	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823
365044006073	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
365044006074	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
365044006075	GIY-YIG motif/motif A; other site
365044006076	active site
365044006077	catalytic site [active]
365044006078	putative DNA binding site [nucleotide binding]; other site
365044006079	metal binding site [ion binding]; metal-binding site
365044006080	UvrB/uvrC motif; Region: UVR; pfam02151
365044006081	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
365044006082	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
365044006083	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
365044006084	transcriptional activator TtdR; Provisional; Region: PRK09801
365044006085	Helix-turn-helix domains; Region: HTH; cl00088
365044006086	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
365044006087	putative effector binding pocket; other site
365044006088	putative dimerization interface [polypeptide binding]; other site
365044006089	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044006090	tartrate dehydrogenase; Provisional; Region: PRK08194
365044006091	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
365044006092	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365044006093	IHF dimer interface [polypeptide binding]; other site
365044006094	IHF - DNA interface [nucleotide binding]; other site
365044006095	SurA N-terminal domain; Region: SurA_N_3; cl07813
365044006096	periplasmic folding chaperone; Provisional; Region: PRK10788
365044006097	PPIC-type PPIASE domain; Region: Rotamase; cl08278
365044006098	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
365044006099	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
365044006100	elongation factor G; Reviewed; Region: PRK00007
365044006101	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
365044006102	G1 box; other site
365044006103	putative GEF interaction site [polypeptide binding]; other site
365044006104	GTP/Mg2+ binding site [chemical binding]; other site
365044006105	Switch I region; other site
365044006106	G2 box; other site
365044006107	G3 box; other site
365044006108	Switch II region; other site
365044006109	G4 box; other site
365044006110	G5 box; other site
365044006111	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
365044006112	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
365044006113	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
365044006114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006115	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006116	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006117	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
365044006118	Predicted membrane protein [Function unknown]; Region: COG4267
365044006119	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
365044006120	GAF domain; Region: GAF; cl15785
365044006121	Tetratricopeptide repeat; Region: TPR_15; pfam13429
365044006122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
365044006123	binding surface
365044006124	TPR motif; other site
365044006125	TM1410 hypothetical-related protein; Region: DUF297; cl00997
365044006126	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
365044006127	Helix-turn-helix domains; Region: HTH; cl00088
365044006128	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044006129	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
365044006130	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044006131	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044006132	shikimate binding site; other site
365044006133	NAD(P) binding site [chemical binding]; other site
365044006134	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044006135	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
365044006136	ligand binding site [chemical binding]; other site
365044006137	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044006138	TM-ABC transporter signature motif; other site
365044006139	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044006140	TM-ABC transporter signature motif; other site
365044006141	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044006142	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044006143	Walker A/P-loop; other site
365044006144	ATP binding site [chemical binding]; other site
365044006145	Q-loop/lid; other site
365044006146	ABC transporter signature motif; other site
365044006147	Walker B; other site
365044006148	D-loop; other site
365044006149	H-loop/switch region; other site
365044006150	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044006151	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044006152	Walker A/P-loop; other site
365044006153	ATP binding site [chemical binding]; other site
365044006154	Q-loop/lid; other site
365044006155	ABC transporter signature motif; other site
365044006156	Walker B; other site
365044006157	D-loop; other site
365044006158	H-loop/switch region; other site
365044006159	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
365044006160	dimer interface [polypeptide binding]; other site
365044006161	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044006162	active site
365044006163	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
365044006164	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
365044006165	Lyase; Region: Lyase_1; pfam00206
365044006166	tetramer interface [polypeptide binding]; other site
365044006167	active site
365044006168	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044006169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006170	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
365044006171	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044006172	Helix-turn-helix domains; Region: HTH; cl00088
365044006173	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
365044006174	putative substrate binding pocket [chemical binding]; other site
365044006175	putative dimerization interface [polypeptide binding]; other site
365044006176	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
365044006177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044006178	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
365044006179	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
365044006180	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044006181	active site
365044006182	metal binding site [ion binding]; metal-binding site
365044006183	DNA binding site [nucleotide binding]
365044006184	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044006185	AAA domain; Region: AAA_27; pfam13514
365044006186	Walker A/P-loop; other site
365044006187	ATP binding site [chemical binding]; other site
365044006188	AAA domain; Region: AAA_27; pfam13514
365044006189	AAA domain; Region: AAA_27; pfam13514
365044006190	Cytochrome c; Region: Cytochrom_C; cl11414
365044006191	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
365044006192	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
365044006193	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
365044006194	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
365044006195	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
365044006196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044006197	Walker A motif; other site
365044006198	ATP binding site [chemical binding]; other site
365044006199	Walker B motif; other site
365044006200	arginine finger; other site
365044006201	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
365044006202	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
365044006203	recombination protein RecR; Reviewed; Region: recR; PRK00076
365044006204	RecR protein; Region: RecR; pfam02132
365044006205	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
365044006206	putative active site [active]
365044006207	putative metal-binding site [ion binding]; other site
365044006208	tetramer interface [polypeptide binding]; other site
365044006209	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
365044006210	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
365044006211	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
365044006212	NMT1-like family; Region: NMT1_2; cl15260
365044006213	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044006214	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
365044006215	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044006216	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044006217	catalytic residue [active]
365044006218	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044006219	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044006220	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044006221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044006222	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
365044006223	RNA/DNA hybrid binding site [nucleotide binding]; other site
365044006224	active site
365044006225	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044006226	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044006227	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044006228	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044006229	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
365044006230	active site
365044006231	catalytic triad [active]
365044006232	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
365044006233	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044006234	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044006235	DNA binding residues [nucleotide binding]
365044006236	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
365044006237	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
365044006238	dimer interface [polypeptide binding]; other site
365044006239	putative functional site; other site
365044006240	putative MPT binding site; other site
365044006241	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
365044006242	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
365044006243	GTP binding site; other site
365044006244	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
365044006245	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044006246	FeS/SAM binding site; other site
365044006247	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
365044006248	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044006249	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044006250	putative ligand binding site [chemical binding]; other site
365044006251	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044006252	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
365044006253	NAD(P) binding site [chemical binding]; other site
365044006254	catalytic residues [active]
365044006255	catalytic residues [active]
365044006256	Chemotaxis phosphatase CheX; Region: CheX; cl15816
365044006257	Response regulator receiver domain; Region: Response_reg; pfam00072
365044006258	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006259	active site
365044006260	phosphorylation site [posttranslational modification]
365044006261	intermolecular recognition site; other site
365044006262	dimerization interface [polypeptide binding]; other site
365044006263	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044006264	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044006265	putative binding surface; other site
365044006266	active site
365044006267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006268	ATP binding site [chemical binding]; other site
365044006269	Mg2+ binding site [ion binding]; other site
365044006270	G-X-G motif; other site
365044006271	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
365044006272	XAP5, circadian clock regulator; Region: XAP5; pfam04921
365044006273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044006274	NMT1-like family; Region: NMT1_2; cl15260
365044006275	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
365044006276	Dehydratase family; Region: ILVD_EDD; cl00340
365044006277	RRXRR protein; Region: RRXRR; pfam14239
365044006278	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
365044006279	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044006280	active site
365044006281	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044006282	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044006283	DNA-binding site [nucleotide binding]; DNA binding site
365044006284	FCD domain; Region: FCD; cl11656
365044006285	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
365044006286	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
365044006287	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
365044006288	dimer interface [polypeptide binding]; other site
365044006289	substrate binding site [chemical binding]; other site
365044006290	metal binding sites [ion binding]; metal-binding site
365044006291	CheB methylesterase; Region: CheB_methylest; pfam01339
365044006292	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
365044006293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044006294	Autophagy protein 16 (ATG16); Region: ATG16; pfam08614
365044006295	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
365044006296	PAS domain; Region: PAS_10; pfam13596
365044006297	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044006298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044006299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044006300	dimer interface [polypeptide binding]; other site
365044006301	phosphorylation site [posttranslational modification]
365044006302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006303	ATP binding site [chemical binding]; other site
365044006304	Mg2+ binding site [ion binding]; other site
365044006305	G-X-G motif; other site
365044006306	Response regulator receiver domain; Region: Response_reg; pfam00072
365044006307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006308	active site
365044006309	phosphorylation site [posttranslational modification]
365044006310	intermolecular recognition site; other site
365044006311	dimerization interface [polypeptide binding]; other site
365044006312	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
365044006313	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044006314	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044006315	Protein of unknown function, DUF482; Region: DUF482; pfam04339
365044006316	NAD synthetase; Provisional; Region: PRK13981
365044006317	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
365044006318	multimer interface [polypeptide binding]; other site
365044006319	active site
365044006320	catalytic triad [active]
365044006321	protein interface 1 [polypeptide binding]; other site
365044006322	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
365044006323	homodimer interface [polypeptide binding]; other site
365044006324	NAD binding pocket [chemical binding]; other site
365044006325	ATP binding pocket [chemical binding]; other site
365044006326	Mg binding site [ion binding]; other site
365044006327	active-site loop [active]
365044006328	Nitrogen regulatory protein P-II; Region: P-II; cl00412
365044006329	Nitrogen regulatory protein P-II; Region: P-II; smart00938
365044006330	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
365044006331	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
365044006332	RDD family; Region: RDD; cl00746
365044006333	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
365044006334	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
365044006335	RNA polymerase factor sigma-70; Validated; Region: PRK09047
365044006336	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044006337	DNA binding residues [nucleotide binding]
365044006338	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
365044006339	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365044006340	PYR/PP interface [polypeptide binding]; other site
365044006341	dimer interface [polypeptide binding]; other site
365044006342	TPP binding site [chemical binding]; other site
365044006343	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
365044006344	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
365044006345	TPP-binding site [chemical binding]; other site
365044006346	dimer interface [polypeptide binding]; other site
365044006347	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
365044006348	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
365044006349	putative valine binding site [chemical binding]; other site
365044006350	dimer interface [polypeptide binding]; other site
365044006351	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
365044006352	ketol-acid reductoisomerase; Provisional; Region: PRK05479
365044006353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006354	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
365044006355	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
365044006356	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
365044006357	2-isopropylmalate synthase; Validated; Region: PRK00915
365044006358	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
365044006359	active site
365044006360	catalytic residues [active]
365044006361	metal binding site [ion binding]; metal-binding site
365044006362	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
365044006363	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
365044006364	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044006365	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044006366	Helix-turn-helix domains; Region: HTH; cl00088
365044006367	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044006368	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
365044006369	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
365044006370	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044006371	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044006372	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044006373	active site
365044006374	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
365044006375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044006376	Walker A motif; other site
365044006377	ATP binding site [chemical binding]; other site
365044006378	Transcriptional regulator; Region: Transcrip_reg; cl00361
365044006379	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
365044006380	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
365044006381	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044006382	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
365044006383	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
365044006384	Oligomerisation domain; Region: Oligomerisation; cl00519
365044006385	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
365044006386	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
365044006387	Maf-like protein; Region: Maf; pfam02545
365044006388	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
365044006389	active site
365044006390	dimer interface [polypeptide binding]; other site
365044006391	ribonuclease G; Provisional; Region: PRK11712
365044006392	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
365044006393	homodimer interface [polypeptide binding]; other site
365044006394	oligonucleotide binding site [chemical binding]; other site
365044006395	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
365044006396	putative active site [active]
365044006397	putative metal binding site [ion binding]; other site
365044006398	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044006399	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
365044006400	Helix-turn-helix domains; Region: HTH; cl00088
365044006401	Winged helix-turn helix; Region: HTH_29; pfam13551
365044006402	Winged helix-turn helix; Region: HTH_33; pfam13592
365044006403	Integrase core domain; Region: rve; cl01316
365044006404	Helix-turn-helix domains; Region: HTH; cl00088
365044006405	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044006406	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044006407	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044006408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
365044006409	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
365044006410	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
365044006411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006412	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006413	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
365044006415	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006416	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006417	Transposase domain (DUF772); Region: DUF772; pfam05598
365044006418	Helix-turn-helix domains; Region: HTH; cl00088
365044006419	putative transposase OrfB; Reviewed; Region: PHA02517
365044006420	HTH-like domain; Region: HTH_21; pfam13276
365044006421	Integrase core domain; Region: rve; cl01316
365044006422	Integrase core domain; Region: rve_3; cl15866
365044006423	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044006424	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044006425	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
365044006426	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044006427	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044006428	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
365044006429	BON domain; Region: BON; cl02771
365044006430	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044006431	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
365044006432	amidase; Provisional; Region: PRK07056
365044006433	Amidase; Region: Amidase; cl11426
365044006434	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
365044006435	rRNA interaction site [nucleotide binding]; other site
365044006436	S8 interaction site; other site
365044006437	putative laminin-1 binding site; other site
365044006438	elongation factor Ts; Provisional; Region: tsf; PRK09377
365044006439	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
365044006440	Elongation factor TS; Region: EF_TS; pfam00889
365044006441	Elongation factor TS; Region: EF_TS; pfam00889
365044006442	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
365044006443	putative nucleotide binding site [chemical binding]; other site
365044006444	uridine monophosphate binding site [chemical binding]; other site
365044006445	homohexameric interface [polypeptide binding]; other site
365044006446	ribosome recycling factor; Reviewed; Region: frr; PRK00083
365044006447	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
365044006448	hinge region; other site
365044006449	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
365044006450	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
365044006451	catalytic residue [active]
365044006452	putative FPP diphosphate  binding site; other site
365044006453	putative FPP binding hydrophobic cleft; other site
365044006454	dimer interface [polypeptide binding]; other site
365044006455	putative IPP diphosphate binding site; other site
365044006456	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
365044006457	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
365044006458	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
365044006459	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
365044006460	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
365044006461	zinc metallopeptidase RseP; Provisional; Region: PRK10779
365044006462	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
365044006463	active site
365044006464	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
365044006465	protein binding site [polypeptide binding]; other site
365044006466	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
365044006467	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
365044006468	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044006469	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044006470	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044006471	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044006472	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044006473	Surface antigen; Region: Bac_surface_Ag; cl03097
365044006474	periplasmic chaperone; Provisional; Region: PRK10780
365044006475	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
365044006476	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
365044006477	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
365044006478	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
365044006479	trimer interface [polypeptide binding]; other site
365044006480	active site
365044006481	UDP-GlcNAc binding site [chemical binding]; other site
365044006482	lipid binding site [chemical binding]; lipid-binding site
365044006483	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
365044006484	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
365044006485	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
365044006486	active site
365044006487	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
365044006488	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
365044006489	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
365044006490	RNA/DNA hybrid binding site [nucleotide binding]; other site
365044006491	active site
365044006492	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
365044006493	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
365044006494	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
365044006495	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
365044006496	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
365044006497	catalytic site [active]
365044006498	subunit interface [polypeptide binding]; other site
365044006499	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
365044006500	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044006501	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044006502	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
365044006503	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044006504	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044006505	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
365044006506	substrate binding site [chemical binding]; other site
365044006507	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
365044006508	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
365044006509	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
365044006510	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
365044006511	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
365044006512	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
365044006513	homodimer interface [polypeptide binding]; other site
365044006514	NADP binding site [chemical binding]; other site
365044006515	substrate binding site [chemical binding]; other site
365044006516	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
365044006517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006518	active site
365044006519	phosphorylation site [posttranslational modification]
365044006520	intermolecular recognition site; other site
365044006521	dimerization interface [polypeptide binding]; other site
365044006522	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044006523	DNA binding residues [nucleotide binding]
365044006524	dimerization interface [polypeptide binding]; other site
365044006525	PAS domain S-box; Region: sensory_box; TIGR00229
365044006526	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044006527	putative active site [active]
365044006528	heme pocket [chemical binding]; other site
365044006529	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
365044006530	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044006531	dimer interface [polypeptide binding]; other site
365044006532	phosphorylation site [posttranslational modification]
365044006533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044006534	ATP binding site [chemical binding]; other site
365044006535	Mg2+ binding site [ion binding]; other site
365044006536	G-X-G motif; other site
365044006537	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
365044006538	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
365044006539	dimer interface [polypeptide binding]; other site
365044006540	TPP-binding site [chemical binding]; other site
365044006541	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
365044006542	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006543	E3 interaction surface; other site
365044006544	lipoyl attachment site [posttranslational modification]; other site
365044006545	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006546	E3 interaction surface; other site
365044006547	lipoyl attachment site [posttranslational modification]; other site
365044006548	e3 binding domain; Region: E3_binding; pfam02817
365044006549	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
365044006550	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
365044006551	active site
365044006552	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006553	E3 interaction surface; other site
365044006554	lipoyl attachment site [posttranslational modification]; other site
365044006555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006556	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
365044006557	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044006558	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
365044006559	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044006560	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
365044006561	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
365044006562	NlpC/P60 family; Region: NLPC_P60; cl11438
365044006563	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
365044006564	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
365044006565	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
365044006566	Permease; Region: Permease; cl00510
365044006567	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
365044006568	mce related protein; Region: MCE; pfam02470
365044006569	putative chaperone; Provisional; Region: PRK11678
365044006570	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
365044006571	catalytic triad [active]
365044006572	dimer interface [polypeptide binding]; other site
365044006573	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044006574	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
365044006575	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
365044006576	Isochorismatase family; Region: Isochorismatase; pfam00857
365044006577	catalytic triad [active]
365044006578	dimer interface [polypeptide binding]; other site
365044006579	conserved cis-peptide bond; other site
365044006580	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
365044006581	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044006582	metal binding site [ion binding]; metal-binding site
365044006583	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
365044006584	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
365044006585	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044006586	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
365044006587	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
365044006588	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
365044006589	AMP-binding enzyme; Region: AMP-binding; cl15778
365044006590	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044006591	Integrase core domain; Region: rve; cl01316
365044006592	Winged helix-turn helix; Region: HTH_33; pfam13592
365044006593	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
365044006594	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
365044006595	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
365044006596	ABC transporter; Region: ABC_tran_2; pfam12848
365044006597	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
365044006598	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
365044006599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044006600	S-adenosylmethionine binding site [chemical binding]; other site
365044006601	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
365044006602	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
365044006603	metal binding site [ion binding]; metal-binding site
365044006604	dimer interface [polypeptide binding]; other site
365044006605	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
365044006606	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044006607	Walker A motif; other site
365044006608	ATP binding site [chemical binding]; other site
365044006609	Walker B motif; other site
365044006610	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
365044006611	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
365044006612	active site
365044006613	substrate binding site [chemical binding]; other site
365044006614	trimer interface [polypeptide binding]; other site
365044006615	CoA binding site [chemical binding]; other site
365044006616	succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538
365044006617	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044006618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044006619	homodimer interface [polypeptide binding]; other site
365044006620	catalytic residue [active]
365044006621	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044006622	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
365044006623	Walker A/P-loop; other site
365044006624	ATP binding site [chemical binding]; other site
365044006625	Q-loop/lid; other site
365044006626	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044006627	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
365044006628	ABC transporter signature motif; other site
365044006629	Walker B; other site
365044006630	D-loop; other site
365044006631	H-loop/switch region; other site
365044006632	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
365044006633	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
365044006634	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
365044006635	nucleotide binding pocket [chemical binding]; other site
365044006636	K-X-D-G motif; other site
365044006637	catalytic site [active]
365044006638	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
365044006639	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
365044006640	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
365044006641	Dimer interface [polypeptide binding]; other site
365044006642	BRCT sequence motif; other site
365044006643	Protein of unknown function (DUF454); Region: DUF454; cl01063
365044006644	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
365044006645	active site
365044006646	catalytic residues [active]
365044006647	metal binding site [ion binding]; metal-binding site
365044006648	PII uridylyl-transferase; Provisional; Region: PRK03059
365044006649	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044006650	metal binding triad; other site
365044006651	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
365044006652	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
365044006653	Zn2+ binding site [ion binding]; other site
365044006654	Mg2+ binding site [ion binding]; other site
365044006655	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
365044006656	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
365044006657	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
365044006658	active site
365044006659	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
365044006660	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
365044006661	dimerization interface [polypeptide binding]; other site
365044006662	ATP binding site [chemical binding]; other site
365044006663	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
365044006664	dimerization interface [polypeptide binding]; other site
365044006665	ATP binding site [chemical binding]; other site
365044006666	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
365044006667	putative active site [active]
365044006668	catalytic triad [active]
365044006669	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
365044006670	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044006671	oligomeric interface; other site
365044006672	putative active site [active]
365044006673	homodimer interface [polypeptide binding]; other site
365044006674	Integrase core domain; Region: rve; cl01316
365044006675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044006676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044006677	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
365044006678	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
365044006679	active site
365044006680	phosphate binding residues; other site
365044006681	catalytic residues [active]
365044006682	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044006683	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
365044006684	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
365044006685	hydroperoxidase II; Provisional; Region: katE; PRK11249
365044006686	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
365044006687	tetramer interface [polypeptide binding]; other site
365044006688	heme binding pocket [chemical binding]; other site
365044006689	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
365044006690	domain interactions; other site
365044006691	SurA N-terminal domain; Region: SurA_N_3; cl07813
365044006692	PPIC-type PPIASE domain; Region: Rotamase; cl08278
365044006693	BolA-like protein; Region: BolA; cl00386
365044006694	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044006695	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
365044006696	Probable transposase; Region: OrfB_IS605; pfam01385
365044006697	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044006698	Intracellular septation protein A; Region: IspA; cl01098
365044006699	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
365044006700	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
365044006701	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
365044006702	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
365044006703	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
365044006704	AMP-binding enzyme; Region: AMP-binding; cl15778
365044006705	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044006706	TM-ABC transporter signature motif; other site
365044006707	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044006708	TM-ABC transporter signature motif; other site
365044006709	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044006710	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044006711	Walker A/P-loop; other site
365044006712	ATP binding site [chemical binding]; other site
365044006713	Q-loop/lid; other site
365044006714	ABC transporter signature motif; other site
365044006715	Walker B; other site
365044006716	D-loop; other site
365044006717	H-loop/switch region; other site
365044006718	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044006719	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044006720	Walker A/P-loop; other site
365044006721	ATP binding site [chemical binding]; other site
365044006722	Q-loop/lid; other site
365044006723	ABC transporter signature motif; other site
365044006724	Walker B; other site
365044006725	D-loop; other site
365044006726	H-loop/switch region; other site
365044006727	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044006728	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
365044006729	substrate binding site [chemical binding]; other site
365044006730	oxyanion hole (OAH) forming residues; other site
365044006731	trimer interface [polypeptide binding]; other site
365044006732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006733	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044006734	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044006735	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
365044006736	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044006737	dimer interface [polypeptide binding]; other site
365044006738	active site
365044006739	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
365044006740	classical (c) SDRs; Region: SDR_c; cd05233
365044006741	NAD(P) binding site [chemical binding]; other site
365044006742	active site
365044006743	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044006744	CoenzymeA binding site [chemical binding]; other site
365044006745	subunit interaction site [polypeptide binding]; other site
365044006746	PHB binding site; other site
365044006747	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
365044006748	Prostaglandin dehydrogenases; Region: PGDH; cd05288
365044006749	NAD(P) binding site [chemical binding]; other site
365044006750	substrate binding site [chemical binding]; other site
365044006751	dimer interface [polypeptide binding]; other site
365044006752	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044006753	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044006754	active site
365044006755	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044006756	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
365044006757	C-terminal domain interface [polypeptide binding]; other site
365044006758	GSH binding site (G-site) [chemical binding]; other site
365044006759	dimer interface [polypeptide binding]; other site
365044006760	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
365044006761	N-terminal domain interface [polypeptide binding]; other site
365044006762	dimer interface [polypeptide binding]; other site
365044006763	substrate binding pocket (H-site) [chemical binding]; other site
365044006764	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044006765	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044006766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044006767	active site
365044006768	phosphorylation site [posttranslational modification]
365044006769	intermolecular recognition site; other site
365044006770	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044006771	DNA binding residues [nucleotide binding]
365044006772	dimerization interface [polypeptide binding]; other site
365044006773	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044006774	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
365044006775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006776	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
365044006777	L-serine binding site [chemical binding]; other site
365044006778	ACT domain interface; other site
365044006779	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
365044006780	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
365044006781	TPP-binding site [chemical binding]; other site
365044006782	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
365044006783	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
365044006784	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
365044006785	E3 interaction surface; other site
365044006786	lipoyl attachment site [posttranslational modification]; other site
365044006787	e3 binding domain; Region: E3_binding; pfam02817
365044006788	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
365044006789	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
365044006790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044006791	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044006792	Predicted ATPase [General function prediction only]; Region: COG1485
365044006793	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044006794	active site
365044006795	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
365044006796	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044006797	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044006798	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
365044006799	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365044006800	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044006801	RNA binding surface [nucleotide binding]; other site
365044006802	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365044006803	active site
365044006804	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
365044006805	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044006806	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044006807	RNA binding surface [nucleotide binding]; other site
365044006808	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044006809	active site
365044006810	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
365044006811	active site
365044006812	multimer interface [polypeptide binding]; other site
365044006813	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
365044006814	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
365044006815	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044006816	binding surface
365044006817	TPR motif; other site
365044006818	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044006819	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
365044006820	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
365044006821	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
365044006822	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
365044006823	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
365044006824	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
365044006825	dimer interface [polypeptide binding]; other site
365044006826	motif 1; other site
365044006827	active site
365044006828	motif 2; other site
365044006829	motif 3; other site
365044006830	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
365044006831	anticodon binding site; other site
365044006832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
365044006833	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
365044006834	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
365044006835	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
365044006836	Trp docking motif [polypeptide binding]; other site
365044006837	active site
365044006838	GTP-binding protein Der; Reviewed; Region: PRK00093
365044006839	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
365044006840	G1 box; other site
365044006841	GTP/Mg2+ binding site [chemical binding]; other site
365044006842	Switch I region; other site
365044006843	G2 box; other site
365044006844	Switch II region; other site
365044006845	G3 box; other site
365044006846	G4 box; other site
365044006847	G5 box; other site
365044006848	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
365044006849	G1 box; other site
365044006850	GTP/Mg2+ binding site [chemical binding]; other site
365044006851	Switch I region; other site
365044006852	G2 box; other site
365044006853	G3 box; other site
365044006854	Switch II region; other site
365044006855	G4 box; other site
365044006856	G5 box; other site
365044006857	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
365044006858	Sm1 motif; other site
365044006859	intra - hexamer interaction site; other site
365044006860	inter - hexamer interaction site [polypeptide binding]; other site
365044006861	nucleotide binding pocket [chemical binding]; other site
365044006862	Sm2 motif; other site
365044006863	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
365044006864	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
365044006865	HflX GTPase family; Region: HflX; cd01878
365044006866	G1 box; other site
365044006867	GTP/Mg2+ binding site [chemical binding]; other site
365044006868	Switch I region; other site
365044006869	G2 box; other site
365044006870	G3 box; other site
365044006871	Switch II region; other site
365044006872	G4 box; other site
365044006873	G5 box; other site
365044006874	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
365044006875	HflK protein; Region: hflK; TIGR01933
365044006876	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
365044006877	HflK protein; Region: hflK; TIGR01933
365044006878	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
365044006879	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
365044006880	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
365044006881	dimer interface [polypeptide binding]; other site
365044006882	motif 1; other site
365044006883	active site
365044006884	motif 2; other site
365044006885	motif 3; other site
365044006886	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
365044006887	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
365044006888	GDP-binding site [chemical binding]; other site
365044006889	ACT binding site; other site
365044006890	IMP binding site; other site
365044006891	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044006892	active site
365044006893	cystathionine beta-lyase; Provisional; Region: PRK07050
365044006894	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044006895	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044006896	catalytic residue [active]
365044006897	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
365044006898	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044006899	active site residue [active]
365044006900	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044006901	Walker A motif; other site
365044006902	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
365044006903	active site
365044006904	catalytic triad [active]
365044006905	oxyanion hole [active]
365044006906	switch loop; other site
365044006907	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
365044006908	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044006909	Walker A/P-loop; other site
365044006910	ATP binding site [chemical binding]; other site
365044006911	Q-loop/lid; other site
365044006912	ABC transporter signature motif; other site
365044006913	Walker B; other site
365044006914	D-loop; other site
365044006915	H-loop/switch region; other site
365044006916	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
365044006917	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
365044006918	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
365044006919	Cytochrome c; Region: Cytochrom_C; cl11414
365044006920	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
365044006921	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
365044006922	putative DNA binding site [nucleotide binding]; other site
365044006923	putative homodimer interface [polypeptide binding]; other site
365044006924	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
365044006925	intracellular protease, PfpI family; Region: PfpI; TIGR01382
365044006926	proposed catalytic triad [active]
365044006927	conserved cys residue [active]
365044006928	CHRD domain; Region: CHRD; cl06473
365044006929	hypothetical protein; Provisional; Region: PRK01254
365044006930	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
365044006931	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
365044006932	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
365044006933	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
365044006934	Fic family protein [Function unknown]; Region: COG3177
365044006935	Fic/DOC family; Region: Fic; cl00960
365044006936	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
365044006937	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044006938	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
365044006939	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006940	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
365044006941	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044006942	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044006943	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044006944	Walker A/P-loop; other site
365044006945	ATP binding site [chemical binding]; other site
365044006946	Q-loop/lid; other site
365044006947	ABC transporter signature motif; other site
365044006948	Walker B; other site
365044006949	D-loop; other site
365044006950	H-loop/switch region; other site
365044006951	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044006952	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044006953	Walker A/P-loop; other site
365044006954	ATP binding site [chemical binding]; other site
365044006955	Q-loop/lid; other site
365044006956	ABC transporter signature motif; other site
365044006957	Walker B; other site
365044006958	D-loop; other site
365044006959	H-loop/switch region; other site
365044006960	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044006961	TM-ABC transporter signature motif; other site
365044006962	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044006963	TM-ABC transporter signature motif; other site
365044006964	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044006965	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
365044006966	putative ligand binding site [chemical binding]; other site
365044006967	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044006968	Integrase core domain; Region: rve; cl01316
365044006969	Winged helix-turn helix; Region: HTH_29; pfam13551
365044006970	Helix-turn-helix domains; Region: HTH; cl00088
365044006971	Winged helix-turn helix; Region: HTH_33; pfam13592
365044006972	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044006973	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
365044006974	FAD binding site [chemical binding]; other site
365044006975	substrate binding site [chemical binding]; other site
365044006976	catalytic base [active]
365044006977	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
365044006978	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
365044006979	putative active site [active]
365044006980	putative substrate binding site [chemical binding]; other site
365044006981	ATP binding site [chemical binding]; other site
365044006982	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044006983	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044006984	ligand binding site [chemical binding]; other site
365044006985	flexible hinge region; other site
365044006986	Helix-turn-helix domains; Region: HTH; cl00088
365044006987	enoyl-CoA hydratase; Provisional; Region: PRK07511
365044006988	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044006989	substrate binding site [chemical binding]; other site
365044006990	oxyanion hole (OAH) forming residues; other site
365044006991	trimer interface [polypeptide binding]; other site
365044006992	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
365044006993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006994	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044006995	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044006996	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
365044006997	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044006998	LexA repressor; Validated; Region: PRK00215
365044006999	Helix-turn-helix domains; Region: HTH; cl00088
365044007000	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
365044007001	Catalytic site [active]
365044007002	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
365044007003	active site
365044007004	homotetramer interface [polypeptide binding]; other site
365044007005	homodimer interface [polypeptide binding]; other site
365044007006	adenylate kinase; Reviewed; Region: adk; PRK00279
365044007007	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
365044007008	AMP-binding site [chemical binding]; other site
365044007009	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
365044007010	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
365044007011	Ligand binding site; other site
365044007012	oligomer interface; other site
365044007013	Trm112p-like protein; Region: Trm112p; cl01066
365044007014	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
365044007015	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
365044007016	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
365044007017	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
365044007018	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
365044007019	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
365044007020	generic binding surface II; other site
365044007021	generic binding surface I; other site
365044007022	superoxide dismutase; Provisional; Region: PRK10543
365044007023	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
365044007024	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
365044007025	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
365044007026	isocitrate dehydrogenase; Validated; Region: PRK07362
365044007027	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
365044007028	Integrase core domain; Region: rve; cl01316
365044007029	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
365044007030	RNA/DNA binding site [nucleotide binding]; other site
365044007031	RRM dimerization site [polypeptide binding]; other site
365044007032	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
365044007033	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
365044007034	Clp amino terminal domain; Region: Clp_N; pfam02861
365044007035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007036	Walker A motif; other site
365044007037	ATP binding site [chemical binding]; other site
365044007038	Walker B motif; other site
365044007039	arginine finger; other site
365044007040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007041	Walker A motif; other site
365044007042	ATP binding site [chemical binding]; other site
365044007043	Walker B motif; other site
365044007044	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
365044007045	exonuclease I; Provisional; Region: sbcB; PRK11779
365044007046	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
365044007047	active site
365044007048	catalytic site [active]
365044007049	substrate binding site [chemical binding]; other site
365044007050	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
365044007051	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
365044007052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007053	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044007054	Helix-turn-helix domains; Region: HTH; cl00088
365044007055	AsnC family; Region: AsnC_trans_reg; pfam01037
365044007056	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044007057	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
365044007058	putative GSH binding site (G-site) [chemical binding]; other site
365044007059	active site cysteine [active]
365044007060	putative C-terminal domain interface [polypeptide binding]; other site
365044007061	putative dimer interface [polypeptide binding]; other site
365044007062	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
365044007063	putative N-terminal domain interface [polypeptide binding]; other site
365044007064	putative dimer interface [polypeptide binding]; other site
365044007065	putative substrate binding pocket (H-site) [chemical binding]; other site
365044007066	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
365044007067	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
365044007068	active site residue [active]
365044007069	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044007070	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
365044007071	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
365044007072	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
365044007073	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
365044007074	RNA binding site [nucleotide binding]; other site
365044007075	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
365044007076	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
365044007077	putative active site [active]
365044007078	metal binding site [ion binding]; metal-binding site
365044007079	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044007080	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
365044007081	substrate binding pocket [chemical binding]; other site
365044007082	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044007083	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
365044007084	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
365044007085	YceG-like family; Region: YceG; pfam02618
365044007086	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
365044007087	dimerization interface [polypeptide binding]; other site
365044007088	thymidylate kinase; Validated; Region: tmk; PRK00698
365044007089	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
365044007090	TMP-binding site; other site
365044007091	ATP-binding site [chemical binding]; other site
365044007092	DNA polymerase III subunit delta'; Validated; Region: PRK06964
365044007093	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044007094	PilZ domain; Region: PilZ; cl01260
365044007095	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
365044007096	active site
365044007097	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044007098	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044007099	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044007100	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044007101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044007102	putative active site [active]
365044007103	heme pocket [chemical binding]; other site
365044007104	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044007105	dimer interface [polypeptide binding]; other site
365044007106	phosphorylation site [posttranslational modification]
365044007107	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
365044007108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044007109	ATP binding site [chemical binding]; other site
365044007110	G-X-G motif; other site
365044007111	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
365044007112	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
365044007113	hydrogenase 2 small subunit; Provisional; Region: PRK10468
365044007114	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044007115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044007116	active site
365044007117	phosphorylation site [posttranslational modification]
365044007118	intermolecular recognition site; other site
365044007119	dimerization interface [polypeptide binding]; other site
365044007120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007121	Walker A motif; other site
365044007122	ATP binding site [chemical binding]; other site
365044007123	Walker B motif; other site
365044007124	arginine finger; other site
365044007125	Helix-turn-helix domains; Region: HTH; cl00088
365044007126	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
365044007127	putative active site [active]
365044007128	putative substrate binding site [chemical binding]; other site
365044007129	putative cosubstrate binding site; other site
365044007130	catalytic site [active]
365044007131	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
365044007132	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
365044007133	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007134	substrate binding site [chemical binding]; other site
365044007135	oxyanion hole (OAH) forming residues; other site
365044007136	trimer interface [polypeptide binding]; other site
365044007137	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
365044007138	dimerization interface [polypeptide binding]; other site
365044007139	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
365044007140	ATP binding site [chemical binding]; other site
365044007141	Hydrogenase formation hypA family; Region: HypD; cl12072
365044007142	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
365044007143	HupF/HypC family; Region: HupF_HypC; cl00394
365044007144	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
365044007145	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044007146	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
365044007147	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
365044007148	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
365044007149	Protein of unknown function (DUF3457); Region: DUF3457; cl08122
365044007150	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
365044007151	Rubredoxin; Region: Rubredoxin; pfam00301
365044007152	iron binding site [ion binding]; other site
365044007153	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
365044007154	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
365044007155	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
365044007156	HupF/HypC family; Region: HupF_HypC; cl00394
365044007157	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
365044007158	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
365044007159	putative substrate-binding site; other site
365044007160	nickel binding site [ion binding]; other site
365044007161	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044007162	HupE / UreJ protein; Region: HupE_UreJ; cl01011
365044007163	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
365044007164	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
365044007165	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
365044007166	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
365044007167	metal ion-dependent adhesion site (MIDAS); other site
365044007168	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044007169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044007170	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
365044007171	ribulose bisphosphate carboxylase; Provisional; Region: PRK13475
365044007172	Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211
365044007173	dimer interface [polypeptide binding]; other site
365044007174	active site
365044007175	catalytic residue [active]
365044007176	metal binding site [ion binding]; metal-binding site
365044007177	Helix-turn-helix domains; Region: HTH; cl00088
365044007178	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
365044007179	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
365044007180	putative dimerization interface [polypeptide binding]; other site
365044007181	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
365044007182	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044007183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044007184	motif II; other site
365044007185	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
365044007186	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
365044007187	substrate binding site [chemical binding]; other site
365044007188	hexamer interface [polypeptide binding]; other site
365044007189	metal binding site [ion binding]; metal-binding site
365044007190	fructose-1,6-bisphosphatase family protein; Region: PLN02628
365044007191	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
365044007192	AMP binding site [chemical binding]; other site
365044007193	metal binding site [ion binding]; metal-binding site
365044007194	active site
365044007195	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044007196	transketolase; Reviewed; Region: PRK12753
365044007197	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365044007198	TPP-binding site [chemical binding]; other site
365044007199	dimer interface [polypeptide binding]; other site
365044007200	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044007201	PYR/PP interface [polypeptide binding]; other site
365044007202	dimer interface [polypeptide binding]; other site
365044007203	TPP binding site [chemical binding]; other site
365044007204	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044007205	phosphoglycolate phosphatase; Provisional; Region: PRK13222
365044007206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044007207	motif II; other site
365044007208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007209	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
365044007210	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
365044007211	Phosphoglycerate kinase; Region: PGK; pfam00162
365044007212	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
365044007213	substrate binding site [chemical binding]; other site
365044007214	hinge regions; other site
365044007215	ADP binding site [chemical binding]; other site
365044007216	catalytic site [active]
365044007217	hypothetical protein; Provisional; Region: PRK08185
365044007218	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
365044007219	intersubunit interface [polypeptide binding]; other site
365044007220	active site
365044007221	zinc binding site [ion binding]; other site
365044007222	Na+ binding site [ion binding]; other site
365044007223	Helix-turn-helix domains; Region: HTH; cl00088
365044007224	Winged helix-turn helix; Region: HTH_29; pfam13551
365044007225	Helix-turn-helix domains; Region: HTH; cl00088
365044007226	Integrase core domain; Region: rve; cl01316
365044007227	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
365044007228	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
365044007229	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044007230	active site
365044007231	DNA binding site [nucleotide binding]
365044007232	Int/Topo IB signature motif; other site
365044007233	hydroperoxidase II; Provisional; Region: katE; PRK11249
365044007234	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
365044007235	heme binding pocket [chemical binding]; other site
365044007236	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
365044007237	domain interactions; other site
365044007238	cyclase homology domain; Region: CHD; cd07302
365044007239	nucleotidyl binding site; other site
365044007240	metal binding site [ion binding]; metal-binding site
365044007241	dimer interface [polypeptide binding]; other site
365044007242	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
365044007243	phosphopeptide binding site; other site
365044007244	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
365044007245	dimer interface [polypeptide binding]; other site
365044007246	catalytic triad [active]
365044007247	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
365044007248	nucleoside/Zn binding site; other site
365044007249	dimer interface [polypeptide binding]; other site
365044007250	catalytic motif [active]
365044007251	haloalkane dehalogenase; Provisional; Region: PRK00870
365044007252	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
365044007253	GMP synthase; Reviewed; Region: guaA; PRK00074
365044007254	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
365044007255	AMP/PPi binding site [chemical binding]; other site
365044007256	candidate oxyanion hole; other site
365044007257	catalytic triad [active]
365044007258	potential glutamine specificity residues [chemical binding]; other site
365044007259	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
365044007260	ATP Binding subdomain [chemical binding]; other site
365044007261	Ligand Binding sites [chemical binding]; other site
365044007262	Dimerization subdomain; other site
365044007263	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
365044007264	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
365044007265	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
365044007266	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
365044007267	active site
365044007268	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
365044007269	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
365044007270	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
365044007271	putative coenzyme Q binding site [chemical binding]; other site
365044007272	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
365044007273	SmpB-tmRNA interface; other site
365044007274	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
365044007275	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007276	substrate binding site [chemical binding]; other site
365044007277	oxyanion hole (OAH) forming residues; other site
365044007278	trimer interface [polypeptide binding]; other site
365044007279	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
365044007280	Predicted permeases [General function prediction only]; Region: RarD; COG2962
365044007281	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
365044007282	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
365044007283	G1 box; other site
365044007284	putative GEF interaction site [polypeptide binding]; other site
365044007285	GTP/Mg2+ binding site [chemical binding]; other site
365044007286	Switch I region; other site
365044007287	G2 box; other site
365044007288	G3 box; other site
365044007289	Switch II region; other site
365044007290	G4 box; other site
365044007291	G5 box; other site
365044007292	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
365044007293	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
365044007294	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
365044007295	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
365044007296	RNA binding site [nucleotide binding]; other site
365044007297	active site
365044007298	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
365044007299	Ribosome-binding factor A; Region: RBFA; cl00542
365044007300	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
365044007301	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
365044007302	translation initiation factor IF-2; Region: IF-2; TIGR00487
365044007303	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
365044007304	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
365044007305	G1 box; other site
365044007306	putative GEF interaction site [polypeptide binding]; other site
365044007307	GTP/Mg2+ binding site [chemical binding]; other site
365044007308	Switch I region; other site
365044007309	G2 box; other site
365044007310	G3 box; other site
365044007311	Switch II region; other site
365044007312	G4 box; other site
365044007313	G5 box; other site
365044007314	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
365044007315	Translation-initiation factor 2; Region: IF-2; pfam11987
365044007316	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
365044007317	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
365044007318	NusA N-terminal domain; Region: NusA_N; pfam08529
365044007319	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
365044007320	RNA binding site [nucleotide binding]; other site
365044007321	homodimer interface [polypeptide binding]; other site
365044007322	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
365044007323	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
365044007324	G-X-X-G motif; other site
365044007325	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
365044007326	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
365044007327	ribosome maturation protein RimP; Reviewed; Region: PRK00092
365044007328	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
365044007329	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
365044007330	Sm1 motif; other site
365044007331	D1 - D2 interaction site; other site
365044007332	D3 - B interaction site; other site
365044007333	Hfq - Hfq interaction site; other site
365044007334	RNA binding pocket [nucleotide binding]; other site
365044007335	Sm2 motif; other site
365044007336	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
365044007337	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
365044007338	Walker A/P-loop; other site
365044007339	ATP binding site [chemical binding]; other site
365044007340	Q-loop/lid; other site
365044007341	ABC transporter signature motif; other site
365044007342	Walker B; other site
365044007343	D-loop; other site
365044007344	H-loop/switch region; other site
365044007345	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044007346	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
365044007347	Walker A/P-loop; other site
365044007348	ATP binding site [chemical binding]; other site
365044007349	Q-loop/lid; other site
365044007350	ABC transporter signature motif; other site
365044007351	Walker B; other site
365044007352	D-loop; other site
365044007353	H-loop/switch region; other site
365044007354	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044007355	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
365044007356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007357	dimer interface [polypeptide binding]; other site
365044007358	conserved gate region; other site
365044007359	putative PBP binding loops; other site
365044007360	ABC-ATPase subunit interface; other site
365044007361	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
365044007362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007363	dimer interface [polypeptide binding]; other site
365044007364	conserved gate region; other site
365044007365	putative PBP binding loops; other site
365044007366	ABC-ATPase subunit interface; other site
365044007367	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
365044007368	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
365044007369	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
365044007370	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
365044007371	NAD binding site [chemical binding]; other site
365044007372	homotetramer interface [polypeptide binding]; other site
365044007373	homodimer interface [polypeptide binding]; other site
365044007374	substrate binding site [chemical binding]; other site
365044007375	active site
365044007376	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
365044007377	DNA binding site [nucleotide binding]
365044007378	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
365044007379	active site
365044007380	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
365044007381	DNA binding site [nucleotide binding]
365044007382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
365044007383	lysine decarboxylase LdcC; Provisional; Region: PRK15399
365044007384	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044007385	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044007386	catalytic residue [active]
365044007387	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
365044007388	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
365044007389	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
365044007390	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
365044007391	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
365044007392	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
365044007393	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365044007394	active site
365044007395	catalytic tetrad [active]
365044007396	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044007397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007398	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
365044007399	active site
365044007400	Fe(II) binding site [ion binding]; other site
365044007401	dimer interface [polypeptide binding]; other site
365044007402	tetramer interface [polypeptide binding]; other site
365044007403	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
365044007404	dimer interface [polypeptide binding]; other site
365044007405	tetramer interface [polypeptide binding]; other site
365044007406	active site
365044007407	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
365044007408	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
365044007409	active site
365044007410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044007411	NMT1-like family; Region: NMT1_2; cl15260
365044007412	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
365044007413	hypothetical protein; Validated; Region: PRK06201
365044007414	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044007415	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
365044007416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
365044007417	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044007418	Helix-turn-helix domains; Region: HTH; cl00088
365044007419	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
365044007420	putative dimerization interface [polypeptide binding]; other site
365044007421	Helix-turn-helix domains; Region: HTH; cl00088
365044007422	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
365044007423	TOBE domain; Region: TOBE_2; cl01440
365044007424	TOBE domain; Region: TOBE_2; cl01440
365044007425	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044007426	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044007427	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
365044007428	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
365044007429	active site
365044007430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007431	dimer interface [polypeptide binding]; other site
365044007432	conserved gate region; other site
365044007433	putative PBP binding loops; other site
365044007434	ABC-ATPase subunit interface; other site
365044007435	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
365044007436	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044007437	Walker A/P-loop; other site
365044007438	ATP binding site [chemical binding]; other site
365044007439	Q-loop/lid; other site
365044007440	ABC transporter signature motif; other site
365044007441	Walker B; other site
365044007442	D-loop; other site
365044007443	H-loop/switch region; other site
365044007444	TOBE domain; Region: TOBE_2; cl01440
365044007445	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
365044007446	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
365044007447	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
365044007448	catalytic residues [active]
365044007449	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
365044007450	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
365044007451	iron-sulfur cluster [ion binding]; other site
365044007452	[2Fe-2S] cluster binding site [ion binding]; other site
365044007453	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
365044007454	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
365044007455	putative ATP binding site [chemical binding]; other site
365044007456	putative substrate interface [chemical binding]; other site
365044007457	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
365044007458	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
365044007459	Tetratricopeptide repeat; Region: TPR_6; pfam13174
365044007460	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044007461	ligand binding site [chemical binding]; other site
365044007462	translocation protein TolB; Provisional; Region: tolB; PRK02889
365044007463	TolB amino-terminal domain; Region: TolB_N; cl00639
365044007464	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007465	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007466	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007467	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
365044007468	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
365044007469	Substrate binding site; other site
365044007470	metal-binding site
365044007471	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
365044007472	putative metal binding site; other site
365044007473	O-Antigen ligase; Region: Wzy_C; cl04850
365044007474	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
365044007475	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044007476	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
365044007477	Walker A/P-loop; other site
365044007478	ATP binding site [chemical binding]; other site
365044007479	Q-loop/lid; other site
365044007480	ABC transporter signature motif; other site
365044007481	Walker B; other site
365044007482	D-loop; other site
365044007483	H-loop/switch region; other site
365044007484	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
365044007485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007486	dimer interface [polypeptide binding]; other site
365044007487	conserved gate region; other site
365044007488	putative PBP binding loops; other site
365044007489	ABC-ATPase subunit interface; other site
365044007490	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044007491	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
365044007492	Walker A/P-loop; other site
365044007493	ATP binding site [chemical binding]; other site
365044007494	Q-loop/lid; other site
365044007495	ABC transporter signature motif; other site
365044007496	Walker B; other site
365044007497	D-loop; other site
365044007498	H-loop/switch region; other site
365044007499	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
365044007500	translation initiation factor Sui1; Validated; Region: PRK06824
365044007501	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
365044007502	putative rRNA binding site [nucleotide binding]; other site
365044007503	Transglycosylase; Region: Transgly; cl07896
365044007504	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
365044007505	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044007506	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
365044007507	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
365044007508	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
365044007509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044007510	putative substrate translocation pore; other site
365044007511	Transglycosylase; Region: Transgly; cl07896
365044007512	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
365044007513	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044007514	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
365044007515	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044007516	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
365044007517	substrate binding site [chemical binding]; other site
365044007518	ATP binding site [chemical binding]; other site
365044007519	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
365044007520	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
365044007521	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
365044007522	altronate oxidoreductase; Provisional; Region: PRK03643
365044007523	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
365044007524	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
365044007525	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
365044007526	putative NAD(P) binding site [chemical binding]; other site
365044007527	catalytic Zn binding site [ion binding]; other site
365044007528	structural Zn binding site [ion binding]; other site
365044007529	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044007530	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044007531	substrate binding pocket [chemical binding]; other site
365044007532	membrane-bound complex binding site; other site
365044007533	hinge residues; other site
365044007534	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044007535	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
365044007536	Walker A/P-loop; other site
365044007537	ATP binding site [chemical binding]; other site
365044007538	Q-loop/lid; other site
365044007539	ABC transporter signature motif; other site
365044007540	Walker B; other site
365044007541	D-loop; other site
365044007542	H-loop/switch region; other site
365044007543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044007544	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365044007545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007546	dimer interface [polypeptide binding]; other site
365044007547	conserved gate region; other site
365044007548	putative PBP binding loops; other site
365044007549	ABC-ATPase subunit interface; other site
365044007550	Transcriptional regulators [Transcription]; Region: FadR; COG2186
365044007551	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044007552	DNA-binding site [nucleotide binding]; DNA binding site
365044007553	FCD domain; Region: FCD; cl11656
365044007554	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
365044007555	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007557	homodimer interface [polypeptide binding]; other site
365044007558	catalytic residue [active]
365044007559	RRXRR protein; Region: RRXRR; pfam14239
365044007560	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044007561	active site
365044007562	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
365044007563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007564	endonuclease III; Provisional; Region: PRK10702
365044007565	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044007566	minor groove reading motif; other site
365044007567	helix-hairpin-helix signature motif; other site
365044007568	substrate binding pocket [chemical binding]; other site
365044007569	active site
365044007570	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
365044007571	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
365044007572	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
365044007573	putative substrate binding site [chemical binding]; other site
365044007574	putative ATP binding site [chemical binding]; other site
365044007575	phosphoenolpyruvate synthase; Validated; Region: PRK06464
365044007576	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
365044007577	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
365044007578	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044007579	FOG: CBS domain [General function prediction only]; Region: COG0517
365044007580	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
365044007581	Integrase core domain; Region: rve; cl01316
365044007582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044007583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044007584	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
365044007585	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044007586	Ligand Binding Site [chemical binding]; other site
365044007587	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
365044007588	LabA_like proteins; Region: LabA_like; cd06167
365044007589	putative metal binding site [ion binding]; other site
365044007590	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
365044007591	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
365044007592	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044007593	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
365044007594	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
365044007595	putative active site [active]
365044007596	catalytic site [active]
365044007597	putative metal binding site [ion binding]; other site
365044007598	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044007599	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044007600	DNA-binding site [nucleotide binding]; DNA binding site
365044007601	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007602	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007603	homodimer interface [polypeptide binding]; other site
365044007604	catalytic residue [active]
365044007605	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
365044007606	Cytochrome c; Region: Cytochrom_C; cl11414
365044007607	Cytochrome c; Region: Cytochrom_C; cl11414
365044007608	Cytochrome c; Region: Cytochrom_C; cl11414
365044007609	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
365044007610	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044007611	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044007612	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
365044007613	biosynthesis cluster domain; Region: biosyn_clust_1; cl14822
365044007614	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
365044007615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007616	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
365044007617	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
365044007618	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
365044007619	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
365044007620	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
365044007621	dimerization interface [polypeptide binding]; other site
365044007622	putative ATP binding site [chemical binding]; other site
365044007623	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044007624	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
365044007625	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044007626	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
365044007627	putative active site [active]
365044007628	catalytic triad [active]
365044007629	putative dimer interface [polypeptide binding]; other site
365044007630	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
365044007631	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044007632	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044007633	DNA-binding site [nucleotide binding]; DNA binding site
365044007634	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007636	homodimer interface [polypeptide binding]; other site
365044007637	catalytic residue [active]
365044007638	benzoate transporter; Region: benE; TIGR00843
365044007639	Benzoate membrane transport protein; Region: BenE; pfam03594
365044007640	benzoate transport; Region: 2A0115; TIGR00895
365044007641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044007642	putative substrate translocation pore; other site
365044007643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044007644	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044007645	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
365044007646	putative NAD(P) binding site [chemical binding]; other site
365044007647	active site
365044007648	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
365044007649	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044007650	catalytic loop [active]
365044007651	iron binding site [ion binding]; other site
365044007652	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
365044007653	FAD binding pocket [chemical binding]; other site
365044007654	FAD binding motif [chemical binding]; other site
365044007655	phosphate binding motif [ion binding]; other site
365044007656	beta-alpha-beta structure motif; other site
365044007657	NAD binding pocket [chemical binding]; other site
365044007658	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044007659	inter-subunit interface; other site
365044007660	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
365044007661	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
365044007662	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
365044007663	putative alpha subunit interface [polypeptide binding]; other site
365044007664	putative active site [active]
365044007665	putative substrate binding site [chemical binding]; other site
365044007666	Fe binding site [ion binding]; other site
365044007667	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
365044007668	Helix-turn-helix domains; Region: HTH; cl00088
365044007669	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
365044007670	dimerizarion interface [polypeptide binding]; other site
365044007671	CrgA pocket; other site
365044007672	substrate binding pocket [chemical binding]; other site
365044007673	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044007674	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
365044007675	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
365044007676	dimer interface [polypeptide binding]; other site
365044007677	active site
365044007678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044007679	NMT1-like family; Region: NMT1_2; cl15260
365044007680	Muconolactone delta-isomerase; Region: MIase; cl01992
365044007681	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
365044007682	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
365044007683	octamer interface [polypeptide binding]; other site
365044007684	active site
365044007685	Helix-turn-helix domains; Region: HTH; cl00088
365044007686	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
365044007687	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044007688	dimerization interface [polypeptide binding]; other site
365044007689	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
365044007690	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044007691	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044007692	Helix-turn-helix domains; Region: HTH; cl00088
365044007693	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044007694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007695	NAD(P) binding site [chemical binding]; other site
365044007696	active site
365044007697	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007698	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
365044007699	substrate binding site [chemical binding]; other site
365044007700	oxyanion hole (OAH) forming residues; other site
365044007701	trimer interface [polypeptide binding]; other site
365044007702	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
365044007703	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044007704	active site
365044007705	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
365044007706	AMP-binding enzyme; Region: AMP-binding; cl15778
365044007707	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044007708	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044007709	NMT1-like family; Region: NMT1_2; cl15260
365044007710	enoyl-CoA hydratase; Provisional; Region: PRK05862
365044007711	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007712	substrate binding site [chemical binding]; other site
365044007713	oxyanion hole (OAH) forming residues; other site
365044007714	trimer interface [polypeptide binding]; other site
365044007715	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044007716	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044007717	active site
365044007718	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
365044007719	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044007720	FAD binding site [chemical binding]; other site
365044007721	substrate binding pocket [chemical binding]; other site
365044007722	catalytic base [active]
365044007723	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
365044007724	Ligand binding site [chemical binding]; other site
365044007725	Electron transfer flavoprotein domain; Region: ETF; pfam01012
365044007726	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
365044007727	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
365044007728	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
365044007729	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
365044007730	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
365044007731	AMP-binding enzyme; Region: AMP-binding; cl15778
365044007732	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365044007733	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
365044007734	putative NAD(P) binding site [chemical binding]; other site
365044007735	structural Zn binding site [ion binding]; other site
365044007736	fatty acid oxidation complex, alpha subunit, mitochondrial; Region: fa_ox_alpha_mit; TIGR02441
365044007737	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044007738	substrate binding site [chemical binding]; other site
365044007739	oxyanion hole (OAH) forming residues; other site
365044007740	trimer interface [polypeptide binding]; other site
365044007741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007742	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044007743	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044007744	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
365044007745	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044007746	dimer interface [polypeptide binding]; other site
365044007747	active site
365044007748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044007749	NMT1-like family; Region: NMT1_2; cl15260
365044007750	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044007751	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
365044007752	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044007753	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044007754	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044007755	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044007756	active site
365044007757	Uncharacterized conserved protein [Function unknown]; Region: COG3777
365044007758	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
365044007759	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
365044007760	putative active site [active]
365044007761	putative catalytic site [active]
365044007762	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044007763	Helix-turn-helix domains; Region: HTH; cl00088
365044007764	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
365044007765	putative dimerization interface [polypeptide binding]; other site
365044007766	cobyric acid synthase; Provisional; Region: PRK00784
365044007767	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044007768	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
365044007769	catalytic triad [active]
365044007770	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
365044007771	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007773	homodimer interface [polypeptide binding]; other site
365044007774	catalytic residue [active]
365044007775	CobD/Cbib protein; Region: CobD_Cbib; cl00561
365044007776	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
365044007777	putative FMN binding site [chemical binding]; other site
365044007778	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
365044007779	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
365044007780	homodimer interface [polypeptide binding]; other site
365044007781	Walker A motif; other site
365044007782	ATP binding site [chemical binding]; other site
365044007783	hydroxycobalamin binding site [chemical binding]; other site
365044007784	Walker B motif; other site
365044007785	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044007786	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
365044007787	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
365044007788	dimer interface [polypeptide binding]; other site
365044007789	[2Fe-2S] cluster binding site [ion binding]; other site
365044007790	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
365044007791	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044007792	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
365044007793	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
365044007794	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
365044007795	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
365044007796	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
365044007797	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044007798	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
365044007799	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044007800	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
365044007801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044007802	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
365044007803	CbiD; Region: CbiD; cl00828
365044007804	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
365044007805	Precorrin-8X methylmutase; Region: CbiC; pfam02570
365044007806	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
365044007807	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
365044007808	putative active site [active]
365044007809	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
365044007810	putative active site [active]
365044007811	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
365044007812	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
365044007813	Membrane transport protein; Region: Mem_trans; cl09117
365044007814	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
365044007815	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
365044007816	leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404
365044007817	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
365044007818	dimerization interface [polypeptide binding]; other site
365044007819	ligand binding site [chemical binding]; other site
365044007820	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
365044007821	multifunctional aminopeptidase A; Provisional; Region: PRK00913
365044007822	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
365044007823	interface (dimer of trimers) [polypeptide binding]; other site
365044007824	Substrate-binding/catalytic site; other site
365044007825	Zn-binding sites [ion binding]; other site
365044007826	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
365044007827	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
365044007828	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
365044007829	putative active site [active]
365044007830	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
365044007831	Helix-turn-helix domains; Region: HTH; cl00088
365044007832	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
365044007833	substrate binding site [chemical binding]; other site
365044007834	dimerization interface [polypeptide binding]; other site
365044007835	methionine aminotransferase; Validated; Region: PRK09082
365044007836	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044007837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044007838	homodimer interface [polypeptide binding]; other site
365044007839	catalytic residue [active]
365044007840	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
365044007841	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
365044007842	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044007843	ATP binding site [chemical binding]; other site
365044007844	putative Mg++ binding site [ion binding]; other site
365044007845	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044007846	nucleotide binding region [chemical binding]; other site
365044007847	ATP-binding site [chemical binding]; other site
365044007848	Helicase associated domain (HA2); Region: HA2; cl04503
365044007849	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
365044007850	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
365044007851	N-acetylglutamate synthase; Validated; Region: PRK05279
365044007852	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
365044007853	putative feedback inhibition sensing region; other site
365044007854	putative nucleotide binding site [chemical binding]; other site
365044007855	putative substrate binding site [chemical binding]; other site
365044007856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044007857	Coenzyme A binding pocket [chemical binding]; other site
365044007858	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
365044007859	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
365044007860	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044007861	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
365044007862	Protein export membrane protein; Region: SecD_SecF; cl14618
365044007863	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044007864	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044007865	active site
365044007866	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
365044007867	Erythromycin esterase; Region: Erythro_esteras; pfam05139
365044007868	HI0933-like protein; Region: HI0933_like; pfam03486
365044007869	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044007870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044007871	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
365044007872	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
365044007873	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365044007874	DNA binding residues [nucleotide binding]
365044007875	putative dimer interface [polypeptide binding]; other site
365044007876	Helix-turn-helix domains; Region: HTH; cl00088
365044007877	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
365044007878	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
365044007879	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
365044007880	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044007881	catalytic residues [active]
365044007882	transcription termination factor Rho; Provisional; Region: rho; PRK09376
365044007883	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
365044007884	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
365044007885	RNA binding site [nucleotide binding]; other site
365044007886	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
365044007887	multimer interface [polypeptide binding]; other site
365044007888	Walker A motif; other site
365044007889	ATP binding site [chemical binding]; other site
365044007890	Walker B motif; other site
365044007891	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
365044007892	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
365044007893	putative efflux protein, MATE family; Region: matE; TIGR00797
365044007894	MatE; Region: MatE; cl10513
365044007895	MatE; Region: MatE; cl10513
365044007896	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044007897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044007898	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044007899	dimer interface [polypeptide binding]; other site
365044007900	phosphorylation site [posttranslational modification]
365044007901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044007902	ATP binding site [chemical binding]; other site
365044007903	Mg2+ binding site [ion binding]; other site
365044007904	G-X-G motif; other site
365044007905	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
365044007906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044007907	active site
365044007908	phosphorylation site [posttranslational modification]
365044007909	intermolecular recognition site; other site
365044007910	dimerization interface [polypeptide binding]; other site
365044007911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044007912	DNA binding site [nucleotide binding]
365044007913	transcriptional regulator PhoU; Provisional; Region: PRK11115
365044007914	PhoU domain; Region: PhoU; pfam01895
365044007915	PhoU domain; Region: PhoU; pfam01895
365044007916	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
365044007917	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
365044007918	Walker A/P-loop; other site
365044007919	ATP binding site [chemical binding]; other site
365044007920	Q-loop/lid; other site
365044007921	ABC transporter signature motif; other site
365044007922	Walker B; other site
365044007923	D-loop; other site
365044007924	H-loop/switch region; other site
365044007925	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
365044007926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007927	dimer interface [polypeptide binding]; other site
365044007928	conserved gate region; other site
365044007929	putative PBP binding loops; other site
365044007930	ABC-ATPase subunit interface; other site
365044007931	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044007932	dimer interface [polypeptide binding]; other site
365044007933	conserved gate region; other site
365044007934	putative PBP binding loops; other site
365044007935	ABC-ATPase subunit interface; other site
365044007936	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044007937	Fasciclin domain; Region: Fasciclin; cl02663
365044007938	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044007939	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
365044007940	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
365044007941	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
365044007942	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
365044007943	catalytic core [active]
365044007944	polyphosphate kinase; Provisional; Region: PRK05443
365044007945	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
365044007946	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
365044007947	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
365044007948	putative active site [active]
365044007949	catalytic site [active]
365044007950	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
365044007951	putative domain interface [polypeptide binding]; other site
365044007952	putative active site [active]
365044007953	catalytic site [active]
365044007954	thiamine pyrophosphate protein; Validated; Region: PRK08199
365044007955	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
365044007956	PYR/PP interface [polypeptide binding]; other site
365044007957	dimer interface [polypeptide binding]; other site
365044007958	TPP binding site [chemical binding]; other site
365044007959	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
365044007960	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
365044007961	TPP-binding site [chemical binding]; other site
365044007962	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
365044007963	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
365044007964	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365044007965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044007966	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044007967	putative substrate translocation pore; other site
365044007968	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044007969	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
365044007970	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044007971	NAD(P) binding site [chemical binding]; other site
365044007972	catalytic residues [active]
365044007973	CreA protein; Region: CreA; pfam05981
365044007974	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
365044007975	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044007976	HSP70 interaction site [polypeptide binding]; other site
365044007977	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
365044007978	substrate binding site [polypeptide binding]; other site
365044007979	dimer interface [polypeptide binding]; other site
365044007980	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
365044007981	Fic/DOC family; Region: Fic; cl00960
365044007982	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
365044007983	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
365044007984	Clp amino terminal domain; Region: Clp_N; pfam02861
365044007985	Clp amino terminal domain; Region: Clp_N; pfam02861
365044007986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007987	Walker A motif; other site
365044007988	ATP binding site [chemical binding]; other site
365044007989	Walker B motif; other site
365044007990	arginine finger; other site
365044007991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044007992	Walker A motif; other site
365044007993	ATP binding site [chemical binding]; other site
365044007994	Walker B motif; other site
365044007995	arginine finger; other site
365044007996	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
365044007997	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
365044007998	MoaE homodimer interface [polypeptide binding]; other site
365044007999	MoaD interaction [polypeptide binding]; other site
365044008000	active site residues [active]
365044008001	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
365044008002	MoaE interaction surface [polypeptide binding]; other site
365044008003	MoeB interaction surface [polypeptide binding]; other site
365044008004	thiocarboxylated glycine; other site
365044008005	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
365044008006	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
365044008007	dimer interface [polypeptide binding]; other site
365044008008	putative functional site; other site
365044008009	putative MPT binding site; other site
365044008010	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
365044008011	Walker A motif; other site
365044008012	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
365044008013	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
365044008014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008015	catalytic residue [active]
365044008016	homoserine dehydrogenase; Provisional; Region: PRK06349
365044008017	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044008018	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
365044008019	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
365044008020	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
365044008021	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044008022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008023	homodimer interface [polypeptide binding]; other site
365044008024	catalytic residue [active]
365044008025	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
365044008026	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
365044008027	catalytic triad [active]
365044008028	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
365044008029	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
365044008030	putative active site [active]
365044008031	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008032	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
365044008033	catalytic residue [active]
365044008034	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
365044008035	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
365044008036	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
365044008037	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
365044008038	oligomer interface [polypeptide binding]; other site
365044008039	active site residues [active]
365044008040	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
365044008041	Mor transcription activator family; Region: Mor; cl02360
365044008042	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448
365044008043	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
365044008044	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
365044008045	Helix-turn-helix domains; Region: HTH; cl00088
365044008046	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044008047	IMP-specific 5'-nucleotidase; Region: ISN1; pfam06437
365044008048	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
365044008049	ParB-like nuclease domain; Region: ParBc; cl02129
365044008050	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
365044008051	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
365044008052	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044008053	active site
365044008054	DNA binding site [nucleotide binding]
365044008055	Int/Topo IB signature motif; other site
365044008056	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
365044008057	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
365044008058	active site
365044008059	catalytic site [active]
365044008060	substrate binding site [chemical binding]; other site
365044008061	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044008062	catalytic loop [active]
365044008063	iron binding site [ion binding]; other site
365044008064	chaperone protein HscA; Provisional; Region: hscA; PRK05183
365044008065	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
365044008066	co-chaperone HscB; Provisional; Region: hscB; PRK03578
365044008067	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
365044008068	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
365044008069	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
365044008070	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
365044008071	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
365044008072	trimerization site [polypeptide binding]; other site
365044008073	active site
365044008074	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044008075	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
365044008076	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044008077	catalytic residue [active]
365044008078	Helix-turn-helix domains; Region: HTH; cl00088
365044008079	Rrf2 family protein; Region: rrf2_super; TIGR00738
365044008080	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
365044008081	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
365044008082	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
365044008083	catalytic residues [active]
365044008084	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
365044008085	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044008086	Beta-Casp domain; Region: Beta-Casp; cl12567
365044008087	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
365044008088	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044008089	Ligand Binding Site [chemical binding]; other site
365044008090	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
365044008091	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
365044008092	putative NAD(P) binding site [chemical binding]; other site
365044008093	putative substrate binding site [chemical binding]; other site
365044008094	catalytic Zn binding site [ion binding]; other site
365044008095	structural Zn binding site [ion binding]; other site
365044008096	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
365044008097	BON domain; Region: BON; cl02771
365044008098	BON domain; Region: BON; cl02771
365044008099	BON domain; Region: BON; cl02771
365044008100	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
365044008101	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
365044008102	putative dimer interface [polypeptide binding]; other site
365044008103	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044008104	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044008105	Walker A/P-loop; other site
365044008106	ATP binding site [chemical binding]; other site
365044008107	Q-loop/lid; other site
365044008108	ABC transporter signature motif; other site
365044008109	Walker B; other site
365044008110	D-loop; other site
365044008111	H-loop/switch region; other site
365044008112	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044008113	FtsX-like permease family; Region: FtsX; cl15850
365044008114	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044008115	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044008116	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044008117	Ligand Binding Site [chemical binding]; other site
365044008118	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
365044008119	Ligand Binding Site [chemical binding]; other site
365044008120	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
365044008121	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
365044008122	NAD(P) binding site [chemical binding]; other site
365044008123	homotetramer interface [polypeptide binding]; other site
365044008124	homodimer interface [polypeptide binding]; other site
365044008125	active site
365044008126	Chromate transporter; Region: Chromate_transp; pfam02417
365044008127	Chromate transporter; Region: Chromate_transp; pfam02417
365044008128	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
365044008129	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
365044008130	active site
365044008131	catalytic residues [active]
365044008132	metal binding site [ion binding]; metal-binding site
365044008133	serine O-acetyltransferase; Region: cysE; TIGR01172
365044008134	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
365044008135	trimer interface [polypeptide binding]; other site
365044008136	active site
365044008137	substrate binding site [chemical binding]; other site
365044008138	CoA binding site [chemical binding]; other site
365044008139	Nitrogen fixation protein NifW; Region: NifW; cl03935
365044008140	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
365044008141	Ligand binding site [chemical binding]; other site
365044008142	Electron transfer flavoprotein domain; Region: ETF; pfam01012
365044008143	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
365044008144	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
365044008145	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
365044008146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044008147	oxidoreductase; Provisional; Region: PRK10015
365044008148	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
365044008149	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
365044008150	dimer interface [polypeptide binding]; other site
365044008151	[2Fe-2S] cluster binding site [ion binding]; other site
365044008152	NifQ; Region: NifQ; pfam04891
365044008153	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
365044008154	4Fe-4S binding domain; Region: Fer4; cl02805
365044008155	Rop-like; Region: Rop-like; cl02247
365044008156	Protein of unknown function, DUF269; Region: DUF269; cl03973
365044008157	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
365044008158	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
365044008159	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
365044008160	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
365044008161	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
365044008162	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
365044008163	ATP synthase; Region: ATP-synt; cl00365
365044008164	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
365044008165	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
365044008166	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
365044008167	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008168	Walker A motif; other site
365044008169	ATP binding site [chemical binding]; other site
365044008170	Walker B motif; other site
365044008171	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044008172	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
365044008173	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
365044008174	ATP synthase subunit C; Region: ATP-synt_C; cl00466
365044008175	ATP synthase A chain; Region: ATP-synt_A; cl00413
365044008176	N-ATPase, AtpR subunit; Region: AtpR; cl11871
365044008177	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
365044008178	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
365044008179	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
365044008180	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
365044008181	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
365044008182	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
365044008183	alpha subunit interaction interface [polypeptide binding]; other site
365044008184	Walker A motif; other site
365044008185	ATP binding site [chemical binding]; other site
365044008186	Walker B motif; other site
365044008187	inhibitor binding site; inhibition site
365044008188	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
365044008189	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
365044008190	diiron binding motif [ion binding]; other site
365044008191	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044008192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008193	Walker A motif; other site
365044008194	ATP binding site [chemical binding]; other site
365044008195	Walker B motif; other site
365044008196	arginine finger; other site
365044008197	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044008198	catalytic loop [active]
365044008199	iron binding site [ion binding]; other site
365044008200	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
365044008201	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
365044008202	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
365044008203	MoFe protein beta/alpha subunit interactions; other site
365044008204	Beta subunit P cluster binding residues; other site
365044008205	MoFe protein beta subunit/Fe protein contacts; other site
365044008206	MoFe protein dimer/ dimer interactions; other site
365044008207	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
365044008208	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
365044008209	MoFe protein alpha/beta subunit interactions; other site
365044008210	Alpha subunit P cluster binding residues; other site
365044008211	FeMoco binding residues [chemical binding]; other site
365044008212	MoFe protein alpha subunit/Fe protein contacts; other site
365044008213	MoFe protein dimer/ dimer interactions; other site
365044008214	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
365044008215	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
365044008216	Nucleotide-binding sites [chemical binding]; other site
365044008217	Walker A motif; other site
365044008218	Switch I region of nucleotide binding site; other site
365044008219	Fe4S4 binding sites [ion binding]; other site
365044008220	Switch II region of nucleotide binding site; other site
365044008221	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044008222	apolar tunnel; other site
365044008223	heme binding site [chemical binding]; other site
365044008224	dimerization interface [polypeptide binding]; other site
365044008225	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044008226	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044008227	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
365044008228	NADPH bind site [chemical binding]; other site
365044008229	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
365044008230	putative FMN binding site [chemical binding]; other site
365044008231	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
365044008232	active site residue [active]
365044008233	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044008234	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044008235	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044008236	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
365044008237	OsmC-like protein; Region: OsmC; cl00767
365044008238	RNA polymerase sigma factor; Provisional; Region: PRK12520
365044008239	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044008240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044008241	DNA binding residues [nucleotide binding]
365044008242	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044008243	catalytic residues [active]
365044008244	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
365044008245	Protein of unknown function (DUF692); Region: DUF692; cl01263
365044008246	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
365044008247	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
365044008248	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008249	Walker A/P-loop; other site
365044008250	ATP binding site [chemical binding]; other site
365044008251	Q-loop/lid; other site
365044008252	ABC transporter signature motif; other site
365044008253	Walker B; other site
365044008254	D-loop; other site
365044008255	H-loop/switch region; other site
365044008256	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
365044008257	dimer interface [polypeptide binding]; other site
365044008258	putative PBP binding regions; other site
365044008259	ABC-ATPase subunit  interface; other site
365044008260	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
365044008261	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
365044008262	intersubunit interface [polypeptide binding]; other site
365044008263	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
365044008264	homotrimer interface [polypeptide binding]; other site
365044008265	Walker A motif; other site
365044008266	GTP binding site [chemical binding]; other site
365044008267	Walker B motif; other site
365044008268	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
365044008269	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
365044008270	cobalamin binding residues [chemical binding]; other site
365044008271	putative BtuC binding residues; other site
365044008272	dimer interface [polypeptide binding]; other site
365044008273	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
365044008274	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008275	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
365044008276	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
365044008277	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
365044008278	N-terminal plug; other site
365044008279	ligand-binding site [chemical binding]; other site
365044008280	Cell division protein ZapA; Region: ZapA; cl01146
365044008281	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
365044008282	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
365044008283	SWIB/MDM2 domain; Region: SWIB; cl02489
365044008284	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
365044008285	putative active site [active]
365044008286	metal binding site [ion binding]; metal-binding site
365044008287	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
365044008288	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
365044008289	ferredoxin; Provisional; Region: PRK06991
365044008290	Putative Fe-S cluster; Region: FeS; pfam04060
365044008291	4Fe-4S binding domain; Region: Fer4; cl02805
365044008292	4Fe-4S binding domain; Region: Fer4; cl02805
365044008293	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044008294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044008295	dimer interface [polypeptide binding]; other site
365044008296	phosphorylation site [posttranslational modification]
365044008297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044008298	ATP binding site [chemical binding]; other site
365044008299	Mg2+ binding site [ion binding]; other site
365044008300	G-X-G motif; other site
365044008301	Response regulator receiver domain; Region: Response_reg; pfam00072
365044008302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044008303	active site
365044008304	phosphorylation site [posttranslational modification]
365044008305	intermolecular recognition site; other site
365044008306	dimerization interface [polypeptide binding]; other site
365044008307	Response regulator receiver domain; Region: Response_reg; pfam00072
365044008308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044008309	active site
365044008310	phosphorylation site [posttranslational modification]
365044008311	intermolecular recognition site; other site
365044008312	dimerization interface [polypeptide binding]; other site
365044008313	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
365044008314	dimer interface [polypeptide binding]; other site
365044008315	substrate binding site [chemical binding]; other site
365044008316	metal binding site [ion binding]; metal-binding site
365044008317	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
365044008318	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044008319	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044008320	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
365044008321	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044008322	carboxyltransferase (CT) interaction site; other site
365044008323	biotinylation site [posttranslational modification]; other site
365044008324	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
365044008325	putative active site [active]
365044008326	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
365044008327	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044008328	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044008329	membrane ATPase/protein kinase; Provisional; Region: PRK09435
365044008330	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
365044008331	Walker A; other site
365044008332	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008333	G4 box; other site
365044008334	G5 box; other site
365044008335	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
365044008336	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
365044008337	active site
365044008338	substrate binding site [chemical binding]; other site
365044008339	coenzyme B12 binding site [chemical binding]; other site
365044008340	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
365044008341	B12 binding site [chemical binding]; other site
365044008342	cobalt ligand [ion binding]; other site
365044008343	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044008344	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044008345	DNA-binding site [nucleotide binding]; DNA binding site
365044008346	FCD domain; Region: FCD; cl11656
365044008347	SpoVR family protein; Provisional; Region: PRK11767
365044008348	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
365044008349	Uncharacterized conserved protein [Function unknown]; Region: COG2718
365044008350	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044008351	PrkA family serine protein kinase; Provisional; Region: PRK15455
365044008352	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008353	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
365044008354	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
365044008355	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365044008356	FMN binding site [chemical binding]; other site
365044008357	active site
365044008358	catalytic residues [active]
365044008359	substrate binding site [chemical binding]; other site
365044008360	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
365044008361	active site
365044008362	Zn binding site [ion binding]; other site
365044008363	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586
365044008364	RNA/DNA binding site [nucleotide binding]; other site
365044008365	replicative DNA helicase; Region: DnaB; TIGR00665
365044008366	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
365044008367	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
365044008368	Walker A motif; other site
365044008369	ATP binding site [chemical binding]; other site
365044008370	Walker B motif; other site
365044008371	DNA binding loops [nucleotide binding]
365044008372	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
365044008373	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
365044008374	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
365044008375	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
365044008376	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
365044008377	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
365044008378	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
365044008379	Na binding site [ion binding]; other site
365044008380	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
365044008381	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044008382	binding surface
365044008383	TPR motif; other site
365044008384	TPR repeat; Region: TPR_11; pfam13414
365044008385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044008386	binding surface
365044008387	TPR motif; other site
365044008388	TPR repeat; Region: TPR_11; pfam13414
365044008389	phosphoenolpyruvate synthase; Validated; Region: PRK06464
365044008390	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
365044008391	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
365044008392	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044008393	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
365044008394	peroxiredoxin; Region: AhpC; TIGR03137
365044008395	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
365044008396	dimer interface [polypeptide binding]; other site
365044008397	decamer (pentamer of dimers) interface [polypeptide binding]; other site
365044008398	catalytic triad [active]
365044008399	peroxidatic and resolving cysteines [active]
365044008400	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
365044008401	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
365044008402	catalytic residue [active]
365044008403	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
365044008404	catalytic residues [active]
365044008405	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044008406	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044008407	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
365044008408	C-terminal domain interface [polypeptide binding]; other site
365044008409	GSH binding site (G-site) [chemical binding]; other site
365044008410	dimer interface [polypeptide binding]; other site
365044008411	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044008412	N-terminal domain interface [polypeptide binding]; other site
365044008413	dimer interface [polypeptide binding]; other site
365044008414	substrate binding pocket (H-site) [chemical binding]; other site
365044008415	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
365044008416	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
365044008417	putative active site [active]
365044008418	putative metal binding site [ion binding]; other site
365044008419	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008420	ATP binding site [chemical binding]; other site
365044008421	putative Mg++ binding site [ion binding]; other site
365044008422	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044008423	nucleotide binding region [chemical binding]; other site
365044008424	ATP-binding site [chemical binding]; other site
365044008425	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
365044008426	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008427	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008428	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008429	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
365044008430	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044008431	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044008432	TOBE domain; Region: TOBE_2; cl01440
365044008433	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
365044008434	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008435	Walker A/P-loop; other site
365044008436	ATP binding site [chemical binding]; other site
365044008437	Q-loop/lid; other site
365044008438	ABC transporter signature motif; other site
365044008439	Walker B; other site
365044008440	D-loop; other site
365044008441	H-loop/switch region; other site
365044008442	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
365044008443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044008444	putative PBP binding loops; other site
365044008445	dimer interface [polypeptide binding]; other site
365044008446	ABC-ATPase subunit interface; other site
365044008447	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
365044008448	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
365044008449	active site
365044008450	dimer interface [polypeptide binding]; other site
365044008451	non-prolyl cis peptide bond; other site
365044008452	insertion regions; other site
365044008453	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044008454	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044008455	substrate binding pocket [chemical binding]; other site
365044008456	membrane-bound complex binding site; other site
365044008457	hinge residues; other site
365044008458	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
365044008459	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044008460	substrate binding pocket [chemical binding]; other site
365044008461	membrane-bound complex binding site; other site
365044008462	hinge residues; other site
365044008463	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044008464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044008465	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
365044008466	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
365044008467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044008468	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
365044008469	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044008470	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
365044008471	putative ligand binding site [chemical binding]; other site
365044008472	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
365044008473	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
365044008474	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
365044008475	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
365044008476	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
365044008477	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
365044008478	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
365044008479	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044008480	Active Sites [active]
365044008481	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
365044008482	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
365044008483	Active Sites [active]
365044008484	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
365044008485	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008486	G1 box; other site
365044008487	GTP/Mg2+ binding site [chemical binding]; other site
365044008488	G2 box; other site
365044008489	Switch I region; other site
365044008490	G3 box; other site
365044008491	Switch II region; other site
365044008492	G4 box; other site
365044008493	G5 box; other site
365044008494	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
365044008495	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
365044008496	Ferredoxin [Energy production and conversion]; Region: COG1146
365044008497	4Fe-4S binding domain; Region: Fer4; cl02805
365044008498	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
365044008499	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
365044008500	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
365044008501	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
365044008502	dimer interface [polypeptide binding]; other site
365044008503	substrate binding site [chemical binding]; other site
365044008504	ATP binding site [chemical binding]; other site
365044008505	putative carbohydrate kinase; Provisional; Region: PRK10565
365044008506	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
365044008507	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
365044008508	putative substrate binding site [chemical binding]; other site
365044008509	putative ATP binding site [chemical binding]; other site
365044008510	YGGT family; Region: YGGT; cl00508
365044008511	YGGT family; Region: YGGT; cl00508
365044008512	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
365044008513	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
365044008514	RNB domain; Region: RNB; pfam00773
365044008515	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
365044008516	RNA binding site [nucleotide binding]; other site
365044008517	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
365044008518	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
365044008519	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044008520	FeS/SAM binding site; other site
365044008521	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
365044008522	catalytic residues [active]
365044008523	catalytic nucleophile [active]
365044008524	Recombinase; Region: Recombinase; pfam07508
365044008525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008526	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
365044008527	Walker A motif; other site
365044008528	ATP binding site [chemical binding]; other site
365044008529	Walker B motif; other site
365044008530	arginine finger; other site
365044008531	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
365044008532	active site
365044008533	catalytic triad [active]
365044008534	Helix-turn-helix domains; Region: HTH; cl00088
365044008535	Domain of unknown function (DUF955); Region: DUF955; cl01076
365044008536	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044008537	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008538	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
365044008539	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
365044008540	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
365044008541	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
365044008542	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
365044008543	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
365044008544	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
365044008545	ATP binding site [chemical binding]; other site
365044008546	substrate interface [chemical binding]; other site
365044008547	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
365044008548	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
365044008549	maleylacetoacetate isomerase; Region: maiA; TIGR01262
365044008550	C-terminal domain interface [polypeptide binding]; other site
365044008551	GSH binding site (G-site) [chemical binding]; other site
365044008552	putative dimer interface [polypeptide binding]; other site
365044008553	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
365044008554	dimer interface [polypeptide binding]; other site
365044008555	N-terminal domain interface [polypeptide binding]; other site
365044008556	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
365044008557	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044008558	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
365044008559	Cupin domain; Region: Cupin_2; cl09118
365044008560	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044008561	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044008562	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044008563	Walker A/P-loop; other site
365044008564	ATP binding site [chemical binding]; other site
365044008565	Q-loop/lid; other site
365044008566	ABC transporter signature motif; other site
365044008567	Walker B; other site
365044008568	D-loop; other site
365044008569	H-loop/switch region; other site
365044008570	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044008571	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044008572	Walker A/P-loop; other site
365044008573	ATP binding site [chemical binding]; other site
365044008574	Q-loop/lid; other site
365044008575	ABC transporter signature motif; other site
365044008576	Walker B; other site
365044008577	D-loop; other site
365044008578	H-loop/switch region; other site
365044008579	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044008580	TM-ABC transporter signature motif; other site
365044008581	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044008582	TM-ABC transporter signature motif; other site
365044008583	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044008584	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
365044008585	putative ligand binding site [chemical binding]; other site
365044008586	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
365044008587	[2Fe-2S] cluster binding site [ion binding]; other site
365044008588	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044008589	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
365044008590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008591	Walker A motif; other site
365044008592	ATP binding site [chemical binding]; other site
365044008593	Walker B motif; other site
365044008594	Proline dehydrogenase; Region: Pro_dh; cl03282
365044008595	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044008596	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044008597	DNA-binding site [nucleotide binding]; DNA binding site
365044008598	FCD domain; Region: FCD; cl11656
365044008599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008600	Walker A motif; other site
365044008601	ATP binding site [chemical binding]; other site
365044008602	Walker B motif; other site
365044008603	arginine finger; other site
365044008604	Helix-turn-helix domains; Region: HTH; cl00088
365044008605	Integrase core domain; Region: rve; cl01316
365044008606	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
365044008607	Helix-turn-helix domains; Region: HTH; cl00088
365044008608	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044008609	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044008610	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
365044008611	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044008612	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
365044008613	Cupin domain; Region: Cupin_2; cl09118
365044008614	glutathionine S-transferase; Provisional; Region: PRK10542
365044008615	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
365044008616	C-terminal domain interface [polypeptide binding]; other site
365044008617	GSH binding site (G-site) [chemical binding]; other site
365044008618	dimer interface [polypeptide binding]; other site
365044008619	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
365044008620	dimer interface [polypeptide binding]; other site
365044008621	N-terminal domain interface [polypeptide binding]; other site
365044008622	substrate binding pocket (H-site) [chemical binding]; other site
365044008623	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
365044008624	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
365044008625	putative catalytic residue [active]
365044008626	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
365044008627	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365044008628	putative active site [active]
365044008629	catalytic residue [active]
365044008630	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044008631	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
365044008632	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
365044008633	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
365044008634	active site
365044008635	Fe binding site [ion binding]; other site
365044008636	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044008637	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
365044008638	NAD(P) binding site [chemical binding]; other site
365044008639	catalytic residues [active]
365044008640	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
365044008641	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
365044008642	NAD binding site [chemical binding]; other site
365044008643	active site
365044008644	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044008645	inter-subunit interface; other site
365044008646	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
365044008647	iron-sulfur cluster [ion binding]; other site
365044008648	[2Fe-2S] cluster binding site [ion binding]; other site
365044008649	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
365044008650	beta subunit interface [polypeptide binding]; other site
365044008651	alpha subunit interface [polypeptide binding]; other site
365044008652	active site
365044008653	substrate binding site [chemical binding]; other site
365044008654	Fe binding site [ion binding]; other site
365044008655	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
365044008656	[2Fe-2S] cluster binding site [ion binding]; other site
365044008657	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
365044008658	inter-subunit interface; other site
365044008659	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044008660	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
365044008661	iron-sulfur cluster [ion binding]; other site
365044008662	[2Fe-2S] cluster binding site [ion binding]; other site
365044008663	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
365044008664	putative alpha subunit interface [polypeptide binding]; other site
365044008665	putative active site [active]
365044008666	putative substrate binding site [chemical binding]; other site
365044008667	Fe binding site [ion binding]; other site
365044008668	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
365044008669	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044008670	catalytic loop [active]
365044008671	iron binding site [ion binding]; other site
365044008672	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
365044008673	FAD binding pocket [chemical binding]; other site
365044008674	FAD binding motif [chemical binding]; other site
365044008675	phosphate binding motif [ion binding]; other site
365044008676	beta-alpha-beta structure motif; other site
365044008677	NAD binding pocket [chemical binding]; other site
365044008678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044008679	Helix-turn-helix domains; Region: HTH; cl00088
365044008680	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
365044008681	substrate binding pocket [chemical binding]; other site
365044008682	dimerization interface [polypeptide binding]; other site
365044008683	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008684	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044008685	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044008686	catalytic residue [active]
365044008687	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
365044008688	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
365044008689	ATP binding site [chemical binding]; other site
365044008690	Walker A motif; other site
365044008691	hexamer interface [polypeptide binding]; other site
365044008692	Walker B motif; other site
365044008693	Replication initiator protein A; Region: RPA; cl02339
365044008694	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044008695	putative active site [active]
365044008696	TrbC/VIRB2 family; Region: TrbC; cl01583
365044008697	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
365044008698	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
365044008699	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
365044008700	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008701	Domain of unknown function DUF87; Region: DUF87; pfam01935
365044008702	Walker A/P-loop; other site
365044008703	ATP binding site [chemical binding]; other site
365044008704	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008705	ABC transporter signature motif; other site
365044008706	Walker B; other site
365044008707	D-loop; other site
365044008708	H-loop/switch region; other site
365044008709	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
365044008710	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
365044008711	Reovirus RNA-dependent RNA polymerase lambda 3; Region: RdRP_5; pfam07925
365044008712	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044008713	active site
365044008714	metal binding site [ion binding]; metal-binding site
365044008715	interdomain interaction site; other site
365044008716	VirB8 protein; Region: VirB8; cl01500
365044008717	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
365044008718	VirB7 interaction site; other site
365044008719	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
365044008720	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365044008721	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044008722	catalytic residues [active]
365044008723	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
365044008724	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044008725	Helix-turn-helix domains; Region: HTH; cl00088
365044008726	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
365044008727	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
365044008728	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044008729	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
365044008730	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044008731	Integrase core domain; Region: rve; cl01316
365044008732	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
365044008733	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
365044008734	Helix-turn-helix domains; Region: HTH; cl00088
365044008735	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044008736	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
365044008737	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
365044008738	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
365044008739	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
365044008740	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044008741	Walker A motif; other site
365044008742	ATP binding site [chemical binding]; other site
365044008743	Walker B motif; other site
365044008744	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
365044008745	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
365044008746	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
365044008747	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
365044008748	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
365044008749	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
365044008750	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
365044008751	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
365044008752	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
365044008753	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
365044008754	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
365044008755	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
365044008756	synthetase active site [active]
365044008757	NTP binding site [chemical binding]; other site
365044008758	metal binding site [ion binding]; metal-binding site
365044008759	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
365044008760	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
365044008761	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044008762	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
365044008763	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
365044008764	NAD binding site [chemical binding]; other site
365044008765	homotetramer interface [polypeptide binding]; other site
365044008766	homodimer interface [polypeptide binding]; other site
365044008767	substrate binding site [chemical binding]; other site
365044008768	active site
365044008769	N-formylglutamate amidohydrolase; Region: FGase; cl01522
365044008770	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044008771	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
365044008772	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
365044008773	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
365044008774	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
365044008775	putative active site [active]
365044008776	putative metal binding site [ion binding]; other site
365044008777	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
365044008778	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
365044008779	putative lipid kinase; Reviewed; Region: PRK13057
365044008780	Protein of unknown function (DUF541); Region: SIMPL; cl01077
365044008781	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044008782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044008783	active site
365044008784	phosphorylation site [posttranslational modification]
365044008785	intermolecular recognition site; other site
365044008786	dimerization interface [polypeptide binding]; other site
365044008787	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044008788	DNA binding site [nucleotide binding]
365044008789	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044008790	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044008791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044008792	dimer interface [polypeptide binding]; other site
365044008793	phosphorylation site [posttranslational modification]
365044008794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044008795	ATP binding site [chemical binding]; other site
365044008796	Mg2+ binding site [ion binding]; other site
365044008797	G-X-G motif; other site
365044008798	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
365044008799	homotrimer interaction site [polypeptide binding]; other site
365044008800	zinc binding site [ion binding]; other site
365044008801	CDP-binding sites; other site
365044008802	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
365044008803	substrate binding site; other site
365044008804	dimer interface; other site
365044008805	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
365044008806	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
365044008807	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044008808	ATP binding site [chemical binding]; other site
365044008809	putative Mg++ binding site [ion binding]; other site
365044008810	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044008811	nucleotide binding region [chemical binding]; other site
365044008812	ATP-binding site [chemical binding]; other site
365044008813	TRCF domain; Region: TRCF; cl04088
365044008814	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
365044008815	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044008816	oligomeric interface; other site
365044008817	putative active site [active]
365044008818	homodimer interface [polypeptide binding]; other site
365044008819	phosphoserine phosphatase SerB; Region: serB; TIGR00338
365044008820	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044008821	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044008822	motif II; other site
365044008823	Protein of unknown function (DUF3422); Region: DUF3422; cl02073
365044008824	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044008825	active site
365044008826	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
365044008827	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
365044008828	heme binding site [chemical binding]; other site
365044008829	ferroxidase pore; other site
365044008830	ferroxidase diiron center [ion binding]; other site
365044008831	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
365044008832	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
365044008833	N-terminal plug; other site
365044008834	ligand-binding site [chemical binding]; other site
365044008835	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
365044008836	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
365044008837	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
365044008838	active site
365044008839	substrate binding site [chemical binding]; other site
365044008840	FMN binding site [chemical binding]; other site
365044008841	putative catalytic residues [active]
365044008842	Imelysin; Region: Peptidase_M75; cl09159
365044008843	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
365044008844	Imelysin; Region: Peptidase_M75; cl09159
365044008845	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
365044008846	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
365044008847	Gram-negative bacterial tonB protein; Region: TonB; cl10048
365044008848	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
365044008849	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
365044008850	Hemin uptake protein hemP; Region: hemP; cl10043
365044008851	Domain of unknown function (DUF336); Region: DUF336; cl01249
365044008852	YccA-like proteins; Region: YccA_like; cd10433
365044008853	Winged helix-turn helix; Region: HTH_29; pfam13551
365044008854	Helix-turn-helix domains; Region: HTH; cl00088
365044008855	Winged helix-turn helix; Region: HTH_33; pfam13592
365044008856	Integrase core domain; Region: rve; cl01316
365044008857	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
365044008858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044008859	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044008860	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
365044008861	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
365044008862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044008863	Survival protein SurE; Region: SurE; cl00448
365044008864	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
365044008865	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
365044008866	NAD(P) binding site [chemical binding]; other site
365044008867	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044008868	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044008869	Helix-turn-helix domains; Region: HTH; cl00088
365044008870	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044008871	dimerization interface [polypeptide binding]; other site
365044008872	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
365044008873	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
365044008874	putative NADP binding site [chemical binding]; other site
365044008875	putative substrate binding site [chemical binding]; other site
365044008876	active site
365044008877	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044008878	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
365044008879	ArsC family; Region: ArsC; pfam03960
365044008880	catalytic residues [active]
365044008881	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044008882	putative DNA binding site [nucleotide binding]; other site
365044008883	putative Zn2+ binding site [ion binding]; other site
365044008884	Low molecular weight phosphatase family; Region: LMWPc; cd00115
365044008885	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
365044008886	active site
365044008887	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
365044008888	Membrane transport protein; Region: Mem_trans; cl09117
365044008889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044008890	putative acetyltransferase; Provisional; Region: PRK03624
365044008891	Coenzyme A binding pocket [chemical binding]; other site
365044008892	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
365044008893	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044008894	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044008895	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
365044008896	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
365044008897	Protein export membrane protein; Region: SecD_SecF; cl14618
365044008898	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044008899	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
365044008900	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
365044008901	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
365044008902	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044008903	putative metal binding site [ion binding]; other site
365044008904	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044008905	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
365044008906	putative substrate binding site [chemical binding]; other site
365044008907	putative ATP binding site [chemical binding]; other site
365044008908	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
365044008909	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044008910	ligand binding site [chemical binding]; other site
365044008911	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044008912	trimer interface [polypeptide binding]; other site
365044008913	eyelet of channel; other site
365044008914	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
365044008915	TM-ABC transporter signature motif; other site
365044008916	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044008917	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
365044008918	Walker A/P-loop; other site
365044008919	ATP binding site [chemical binding]; other site
365044008920	Q-loop/lid; other site
365044008921	ABC transporter signature motif; other site
365044008922	Walker B; other site
365044008923	D-loop; other site
365044008924	H-loop/switch region; other site
365044008925	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
365044008926	Helix-turn-helix domains; Region: HTH; cl00088
365044008927	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
365044008928	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
365044008929	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
365044008930	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044008931	ligand binding site [chemical binding]; other site
365044008932	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
365044008933	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
365044008934	active site
365044008935	substrate binding site [chemical binding]; other site
365044008936	metal binding site [ion binding]; metal-binding site
365044008937	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
365044008938	dihydropteroate synthase; Region: DHPS; TIGR01496
365044008939	substrate binding pocket [chemical binding]; other site
365044008940	dimer interface [polypeptide binding]; other site
365044008941	inhibitor binding site; inhibition site
365044008942	FtsH Extracellular; Region: FtsH_ext; pfam06480
365044008943	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
365044008944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044008945	Walker A motif; other site
365044008946	ATP binding site [chemical binding]; other site
365044008947	Walker B motif; other site
365044008948	arginine finger; other site
365044008949	Peptidase family M41; Region: Peptidase_M41; pfam01434
365044008950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044008951	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
365044008952	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
365044008953	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
365044008954	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
365044008955	active site
365044008956	Zn binding site [ion binding]; other site
365044008957	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
365044008958	catalytic residues [active]
365044008959	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
365044008960	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044008961	active site
365044008962	dimer interface [polypeptide binding]; other site
365044008963	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
365044008964	quinone interaction residues [chemical binding]; other site
365044008965	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
365044008966	active site
365044008967	catalytic residues [active]
365044008968	FMN binding site [chemical binding]; other site
365044008969	substrate binding site [chemical binding]; other site
365044008970	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
365044008971	catalytic site [active]
365044008972	putative active site [active]
365044008973	putative substrate binding site [chemical binding]; other site
365044008974	probable methyltransferase; Region: TIGR03438
365044008975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044008976	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
365044008977	transcriptional regulator EutR; Provisional; Region: PRK10130
365044008978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044008979	ethanolamine permease; Region: 2A0305; TIGR00908
365044008980	Spore germination protein; Region: Spore_permease; cl15802
365044008981	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
365044008982	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
365044008983	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
365044008984	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
365044008985	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
365044008986	motif 1; other site
365044008987	active site
365044008988	motif 2; other site
365044008989	motif 3; other site
365044008990	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
365044008991	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044008992	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044008993	DNA-binding site [nucleotide binding]; DNA binding site
365044008994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044008995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044008996	homodimer interface [polypeptide binding]; other site
365044008997	catalytic residue [active]
365044008998	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
365044008999	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044009000	inhibitor-cofactor binding pocket; inhibition site
365044009001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009002	catalytic residue [active]
365044009003	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365044009004	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
365044009005	Walker A/P-loop; other site
365044009006	ATP binding site [chemical binding]; other site
365044009007	Q-loop/lid; other site
365044009008	ABC transporter signature motif; other site
365044009009	Walker B; other site
365044009010	D-loop; other site
365044009011	H-loop/switch region; other site
365044009012	TOBE domain; Region: TOBE_2; cl01440
365044009013	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365044009014	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044009015	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
365044009016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044009017	dimer interface [polypeptide binding]; other site
365044009018	conserved gate region; other site
365044009019	putative PBP binding loops; other site
365044009020	ABC-ATPase subunit interface; other site
365044009021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044009022	dimer interface [polypeptide binding]; other site
365044009023	conserved gate region; other site
365044009024	putative PBP binding loops; other site
365044009025	ABC-ATPase subunit interface; other site
365044009026	Arginase family; Region: Arginase; cl00306
365044009027	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044009028	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
365044009029	tetramerization interface [polypeptide binding]; other site
365044009030	NAD(P) binding site [chemical binding]; other site
365044009031	catalytic residues [active]
365044009032	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
365044009033	FMN-binding domain; Region: FMN_bind; cl01081
365044009034	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
365044009035	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044009036	ApbE family; Region: ApbE; cl00643
365044009037	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044009038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009039	active site
365044009040	phosphorylation site [posttranslational modification]
365044009041	intermolecular recognition site; other site
365044009042	dimerization interface [polypeptide binding]; other site
365044009043	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009044	DNA binding residues [nucleotide binding]
365044009045	dimerization interface [polypeptide binding]; other site
365044009046	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044009047	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365044009048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009049	ATP binding site [chemical binding]; other site
365044009050	Mg2+ binding site [ion binding]; other site
365044009051	G-X-G motif; other site
365044009052	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
365044009053	Sel1 repeat; Region: Sel1; cl02723
365044009054	Sel1 repeat; Region: Sel1; cl02723
365044009055	integrase; Provisional; Region: PRK09692
365044009056	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
365044009057	active site
365044009058	Int/Topo IB signature motif; other site
365044009059	YcfA-like protein; Region: YcfA; cl00752
365044009060	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
365044009061	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044009062	Helix-turn-helix domain; Region: HTH_39; pfam14090
365044009063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
365044009064	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
365044009065	active site
365044009066	metal binding site [ion binding]; metal-binding site
365044009067	interdomain interaction site; other site
365044009068	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
365044009069	NMT1/THI5 like; Region: NMT1; pfam09084
365044009070	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306
365044009071	substrate binding pocket [chemical binding]; other site
365044009072	membrane-bound complex binding site; other site
365044009073	PAS domain S-box; Region: sensory_box; TIGR00229
365044009074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009075	putative active site [active]
365044009076	heme pocket [chemical binding]; other site
365044009077	PAS domain; Region: PAS_9; pfam13426
365044009078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009079	putative active site [active]
365044009080	heme pocket [chemical binding]; other site
365044009081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009082	dimer interface [polypeptide binding]; other site
365044009083	phosphorylation site [posttranslational modification]
365044009084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009085	ATP binding site [chemical binding]; other site
365044009086	Mg2+ binding site [ion binding]; other site
365044009087	G-X-G motif; other site
365044009088	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044009089	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044009090	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044009091	PAS domain; Region: PAS_9; pfam13426
365044009092	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009093	DNA binding residues [nucleotide binding]
365044009094	dimerization interface [polypeptide binding]; other site
365044009095	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250
365044009096	30S subunit binding site; other site
365044009097	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
365044009098	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
365044009099	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
365044009100	tetramer interface [polypeptide binding]; other site
365044009101	heme binding pocket [chemical binding]; other site
365044009102	NADPH binding site [chemical binding]; other site
365044009103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044009104	NMT1-like family; Region: NMT1_2; cl15260
365044009105	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
365044009106	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044009107	NAD(P) binding site [chemical binding]; other site
365044009108	catalytic residues [active]
365044009109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
365044009110	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044009111	Dehydratase family; Region: ILVD_EDD; cl00340
365044009112	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
365044009113	Helix-turn-helix domains; Region: HTH; cl00088
365044009114	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
365044009115	putative dimerization interface [polypeptide binding]; other site
365044009116	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
365044009117	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
365044009118	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
365044009119	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
365044009120	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
365044009121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009122	dimer interface [polypeptide binding]; other site
365044009123	phosphorylation site [posttranslational modification]
365044009124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044009125	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044009126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009127	active site
365044009128	phosphorylation site [posttranslational modification]
365044009129	intermolecular recognition site; other site
365044009130	dimerization interface [polypeptide binding]; other site
365044009131	Helix-turn-helix domains; Region: HTH; cl00088
365044009132	DNA binding site [nucleotide binding]
365044009133	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
365044009134	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365044009135	dimer interface [polypeptide binding]; other site
365044009136	active site
365044009137	Phosphopantetheine attachment site; Region: PP-binding; cl09936
365044009138	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
365044009139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044009141	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
365044009142	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
365044009143	active site
365044009144	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044009145	active site
365044009146	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
365044009147	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
365044009148	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044009149	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
365044009150	Bacterial sugar transferase; Region: Bac_transf; cl00939
365044009151	transcriptional regulator EpsA; Region: EpsA; TIGR03020
365044009152	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009153	DNA binding residues [nucleotide binding]
365044009154	dimerization interface [polypeptide binding]; other site
365044009155	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
365044009156	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
365044009157	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
365044009158	lipoyl attachment site [posttranslational modification]; other site
365044009159	glycine dehydrogenase; Provisional; Region: PRK05367
365044009160	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
365044009161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009162	tetramer interface [polypeptide binding]; other site
365044009163	catalytic residue [active]
365044009164	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
365044009165	tetramer interface [polypeptide binding]; other site
365044009166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009167	catalytic residue [active]
365044009168	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
365044009169	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044009170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
365044009171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009172	ATP binding site [chemical binding]; other site
365044009173	Mg2+ binding site [ion binding]; other site
365044009174	G-X-G motif; other site
365044009175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009176	active site
365044009177	phosphorylation site [posttranslational modification]
365044009178	intermolecular recognition site; other site
365044009179	dimerization interface [polypeptide binding]; other site
365044009180	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044009181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009182	active site
365044009183	phosphorylation site [posttranslational modification]
365044009184	intermolecular recognition site; other site
365044009185	dimerization interface [polypeptide binding]; other site
365044009186	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044009187	DNA binding residues [nucleotide binding]
365044009188	dimerization interface [polypeptide binding]; other site
365044009189	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
365044009190	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
365044009191	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
365044009192	Moco binding site; other site
365044009193	metal coordination site [ion binding]; other site
365044009194	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
365044009195	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
365044009196	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
365044009197	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
365044009198	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
365044009199	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
365044009200	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
365044009201	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044009202	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044009203	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
365044009204	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
365044009205	XdhC Rossmann domain; Region: XdhC_C; pfam13478
365044009206	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
365044009207	Ligand binding site; other site
365044009208	metal-binding site
365044009209	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044009210	nudix motif; other site
365044009211	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
365044009212	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044009213	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
365044009214	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044009215	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044009216	active site
365044009217	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
365044009218	NIPSNAP; Region: NIPSNAP; pfam07978
365044009219	NIPSNAP; Region: NIPSNAP; pfam07978
365044009220	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
365044009221	Transcriptional regulator [Transcription]; Region: IclR; COG1414
365044009222	Helix-turn-helix domains; Region: HTH; cl00088
365044009223	Bacterial transcriptional regulator; Region: IclR; pfam01614
365044009224	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044009225	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044009226	shikimate binding site; other site
365044009227	NAD(P) binding site [chemical binding]; other site
365044009228	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
365044009229	Cupin domain; Region: Cupin_2; cl09118
365044009230	Helix-turn-helix domain; Region: HTH_18; pfam12833
365044009231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044009232	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044009233	classical (c) SDRs; Region: SDR_c; cd05233
365044009234	NAD(P) binding site [chemical binding]; other site
365044009235	active site
365044009236	putative succinate dehydrogenase; Reviewed; Region: PRK12842
365044009237	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009238	NIPSNAP; Region: NIPSNAP; pfam07978
365044009239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009240	NAD(P) binding site [chemical binding]; other site
365044009241	active site
365044009242	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044009243	TM-ABC transporter signature motif; other site
365044009244	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044009245	TM-ABC transporter signature motif; other site
365044009246	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044009247	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044009248	Walker A/P-loop; other site
365044009249	ATP binding site [chemical binding]; other site
365044009250	Q-loop/lid; other site
365044009251	ABC transporter signature motif; other site
365044009252	Walker B; other site
365044009253	D-loop; other site
365044009254	H-loop/switch region; other site
365044009255	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044009256	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044009257	Walker A/P-loop; other site
365044009258	ATP binding site [chemical binding]; other site
365044009259	Q-loop/lid; other site
365044009260	ABC transporter signature motif; other site
365044009261	Walker B; other site
365044009262	D-loop; other site
365044009263	H-loop/switch region; other site
365044009264	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044009265	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
365044009266	putative ligand binding site [chemical binding]; other site
365044009267	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
365044009268	putative substrate binding pocket [chemical binding]; other site
365044009269	trimer interface [polypeptide binding]; other site
365044009270	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044009271	extended (e) SDRs; Region: SDR_e; cd08946
365044009272	NAD(P) binding site [chemical binding]; other site
365044009273	active site
365044009274	substrate binding site [chemical binding]; other site
365044009275	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044009276	classical (c) SDRs; Region: SDR_c; cd05233
365044009277	NAD(P) binding site [chemical binding]; other site
365044009278	active site
365044009279	Low molecular weight phosphatase family; Region: LMWPc; cl00105
365044009280	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
365044009281	active site
365044009282	Vesicle coat protein involved in Golgi to plasma membrane transport; Region: Folliculin; pfam11704
365044009283	Predicted acetyltransferase [General function prediction only]; Region: COG3153
365044009284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
365044009285	Coenzyme A binding pocket [chemical binding]; other site
365044009286	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
365044009287	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
365044009288	FMN-binding pocket [chemical binding]; other site
365044009289	flavin binding motif; other site
365044009290	phosphate binding motif [ion binding]; other site
365044009291	beta-alpha-beta structure motif; other site
365044009292	NAD binding pocket [chemical binding]; other site
365044009293	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044009294	catalytic loop [active]
365044009295	iron binding site [ion binding]; other site
365044009296	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
365044009297	Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532
365044009298	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
365044009299	alpha subunit interface [polypeptide binding]; other site
365044009300	active site
365044009301	substrate binding site [chemical binding]; other site
365044009302	Fe binding site [ion binding]; other site
365044009303	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044009304	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044009305	Walker A/P-loop; other site
365044009306	ATP binding site [chemical binding]; other site
365044009307	Q-loop/lid; other site
365044009308	ABC transporter signature motif; other site
365044009309	Walker B; other site
365044009310	D-loop; other site
365044009311	H-loop/switch region; other site
365044009312	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044009313	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044009314	Walker A/P-loop; other site
365044009315	ATP binding site [chemical binding]; other site
365044009316	Q-loop/lid; other site
365044009317	ABC transporter signature motif; other site
365044009318	Walker B; other site
365044009319	D-loop; other site
365044009320	H-loop/switch region; other site
365044009321	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044009322	TM-ABC transporter signature motif; other site
365044009323	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044009324	TM-ABC transporter signature motif; other site
365044009325	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044009326	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
365044009327	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044009328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044009329	DNA-binding site [nucleotide binding]; DNA binding site
365044009330	FCD domain; Region: FCD; cl11656
365044009331	The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949
365044009332	putative active site [active]
365044009333	Fe(II) binding site [ion binding]; other site
365044009334	putative dimer interface [polypeptide binding]; other site
365044009335	putative tetramer interface [polypeptide binding]; other site
365044009336	The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925
365044009337	putative dimer interface [polypeptide binding]; other site
365044009338	putative tetramer interface [polypeptide binding]; other site
365044009339	putative active site [active]
365044009340	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044009341	Helix-turn-helix domains; Region: HTH; cl00088
365044009342	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
365044009343	substrate binding pocket [chemical binding]; other site
365044009344	dimerization interface [polypeptide binding]; other site
365044009345	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
365044009346	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
365044009347	FAD binding pocket [chemical binding]; other site
365044009348	FAD binding motif [chemical binding]; other site
365044009349	phosphate binding motif [ion binding]; other site
365044009350	beta-alpha-beta structure motif; other site
365044009351	NAD binding pocket [chemical binding]; other site
365044009352	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
365044009353	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
365044009354	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044009355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009356	dimer interface [polypeptide binding]; other site
365044009357	phosphorylation site [posttranslational modification]
365044009358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009359	ATP binding site [chemical binding]; other site
365044009360	Mg2+ binding site [ion binding]; other site
365044009361	G-X-G motif; other site
365044009362	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044009363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009364	active site
365044009365	phosphorylation site [posttranslational modification]
365044009366	intermolecular recognition site; other site
365044009367	dimerization interface [polypeptide binding]; other site
365044009368	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044009369	DNA binding site [nucleotide binding]
365044009370	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
365044009371	dimer interface [polypeptide binding]; other site
365044009372	RF-1 domain; Region: RF-1; cl02875
365044009373	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
365044009374	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044009375	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044009376	motif II; other site
365044009377	short chain dehydrogenase; Provisional; Region: PRK06701
365044009378	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
365044009379	NAD binding site [chemical binding]; other site
365044009380	metal binding site [ion binding]; metal-binding site
365044009381	active site
365044009382	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
365044009383	Tetramer interface [polypeptide binding]; other site
365044009384	active site
365044009385	FMN-binding site [chemical binding]; other site
365044009386	Predicted transcriptional regulator [Transcription]; Region: COG2378
365044009387	WYL domain; Region: WYL; cl14852
365044009388	Flagellin N-methylase; Region: FliB; cl00497
365044009389	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044009390	G1 box; other site
365044009391	GTP/Mg2+ binding site [chemical binding]; other site
365044009392	G2 box; other site
365044009393	Switch I region; other site
365044009394	G3 box; other site
365044009395	Switch II region; other site
365044009396	G4 box; other site
365044009397	G5 box; other site
365044009398	Dynamin family; Region: Dynamin_N; pfam00350
365044009399	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044009400	G2 box; other site
365044009401	G3 box; other site
365044009402	Switch II region; other site
365044009403	GTP/Mg2+ binding site [chemical binding]; other site
365044009404	G4 box; other site
365044009405	G5 box; other site
365044009406	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
365044009407	G1 box; other site
365044009408	GTP/Mg2+ binding site [chemical binding]; other site
365044009409	G2 box; other site
365044009410	Switch I region; other site
365044009411	G3 box; other site
365044009412	Switch II region; other site
365044009413	G4 box; other site
365044009414	G5 box; other site
365044009415	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044009416	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044009417	Family description; Region: UvrD_C_2; cl15862
365044009418	Cupin domain; Region: Cupin_2; cl09118
365044009419	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044009420	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
365044009421	putative N-terminal domain interface [polypeptide binding]; other site
365044009422	putative dimer interface [polypeptide binding]; other site
365044009423	putative substrate binding pocket (H-site) [chemical binding]; other site
365044009424	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
365044009425	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
365044009426	FOG: CBS domain [General function prediction only]; Region: COG0517
365044009427	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
365044009428	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
365044009429	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
365044009430	homodimer interface [polypeptide binding]; other site
365044009431	substrate-cofactor binding pocket; other site
365044009432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009433	catalytic residue [active]
365044009434	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044009435	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044009436	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044009437	Helix-turn-helix domains; Region: HTH; cl00088
365044009438	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
365044009439	putative dimerization interface [polypeptide binding]; other site
365044009440	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
365044009441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044009442	NMT1-like family; Region: NMT1_2; cl15260
365044009443	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044009444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044009445	Probable transposase; Region: OrfB_IS605; pfam01385
365044009446	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044009447	NAD-dependent deacetylase; Provisional; Region: PRK00481
365044009448	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
365044009449	GYD domain; Region: GYD; cl01743
365044009450	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044009451	FAD binding domain; Region: FAD_binding_4; pfam01565
365044009452	Berberine and berberine like; Region: BBE; pfam08031
365044009453	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
365044009454	catalytic residues [active]
365044009455	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
365044009456	Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
365044009457	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
365044009458	FAD binding domain; Region: FAD_binding_4; pfam01565
365044009459	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
365044009460	dimerization interface [polypeptide binding]; other site
365044009461	active site
365044009462	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
365044009463	folate binding site [chemical binding]; other site
365044009464	NADP+ binding site [chemical binding]; other site
365044009465	Nitronate monooxygenase; Region: NMO; pfam03060
365044009466	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
365044009467	FMN binding site [chemical binding]; other site
365044009468	substrate binding site [chemical binding]; other site
365044009469	putative catalytic residue [active]
365044009470	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
365044009471	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
365044009472	putative catalytic site [active]
365044009473	putative phosphate binding site [ion binding]; other site
365044009474	active site
365044009475	metal binding site A [ion binding]; metal-binding site
365044009476	DNA binding site [nucleotide binding]
365044009477	putative AP binding site [nucleotide binding]; other site
365044009478	putative metal binding site B [ion binding]; other site
365044009479	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
365044009480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009481	active site
365044009482	phosphorylation site [posttranslational modification]
365044009483	intermolecular recognition site; other site
365044009484	dimerization interface [polypeptide binding]; other site
365044009485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044009486	Walker A motif; other site
365044009487	ATP binding site [chemical binding]; other site
365044009488	Walker B motif; other site
365044009489	arginine finger; other site
365044009490	Helix-turn-helix domains; Region: HTH; cl00088
365044009491	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044009492	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009493	dimer interface [polypeptide binding]; other site
365044009494	phosphorylation site [posttranslational modification]
365044009495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009496	ATP binding site [chemical binding]; other site
365044009497	Mg2+ binding site [ion binding]; other site
365044009498	G-X-G motif; other site
365044009499	glutamine synthetase; Provisional; Region: glnA; PRK09469
365044009500	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
365044009501	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
365044009502	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
365044009503	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
365044009504	putative MPT binding site; other site
365044009505	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
365044009506	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
365044009507	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
365044009508	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
365044009509	NodB motif; other site
365044009510	active site
365044009511	catalytic site [active]
365044009512	metal binding site [ion binding]; metal-binding site
365044009513	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
365044009514	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044009515	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044009516	RNA binding surface [nucleotide binding]; other site
365044009517	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
365044009518	active site
365044009519	uracil binding [chemical binding]; other site
365044009520	phosphoglycolate phosphatase; Provisional; Region: PRK13222
365044009521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044009522	motif II; other site
365044009523	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
365044009524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044009525	S-adenosylmethionine binding site [chemical binding]; other site
365044009526	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044009527	ligand binding site [chemical binding]; other site
365044009528	DNA gyrase subunit A; Validated; Region: PRK05560
365044009529	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
365044009530	CAP-like domain; other site
365044009531	active site
365044009532	primary dimer interface [polypeptide binding]; other site
365044009533	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009534	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009535	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009536	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009537	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009538	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
365044009539	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
365044009540	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
365044009541	homodimer interface [polypeptide binding]; other site
365044009542	substrate-cofactor binding pocket; other site
365044009543	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009544	catalytic residue [active]
365044009545	Chorismate mutase type II; Region: CM_2; cl00693
365044009546	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
365044009547	Prephenate dehydratase; Region: PDT; pfam00800
365044009548	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
365044009549	putative L-Phe binding site [chemical binding]; other site
365044009550	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
365044009551	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009552	bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
365044009553	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
365044009554	hinge; other site
365044009555	active site
365044009556	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
365044009557	CMP-binding site; other site
365044009558	The sites determining sugar specificity; other site
365044009559	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
365044009560	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
365044009561	RNA binding site [nucleotide binding]; other site
365044009562	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
365044009563	RNA binding site [nucleotide binding]; other site
365044009564	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
365044009565	RNA binding site [nucleotide binding]; other site
365044009566	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689
365044009567	RNA binding site [nucleotide binding]; other site
365044009568	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
365044009569	RNA binding site [nucleotide binding]; other site
365044009570	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
365044009571	RNA binding site [nucleotide binding]; other site
365044009572	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365044009573	IHF dimer interface [polypeptide binding]; other site
365044009574	IHF - DNA interface [nucleotide binding]; other site
365044009575	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
365044009576	tetratricopeptide repeat protein; Provisional; Region: PRK11788
365044009577	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044009578	binding surface
365044009579	TPR motif; other site
365044009580	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044009581	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
365044009582	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044009583	putative ribose interaction site [chemical binding]; other site
365044009584	putative ADP binding site [chemical binding]; other site
365044009585	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
365044009586	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
365044009587	NADP binding site [chemical binding]; other site
365044009588	homopentamer interface [polypeptide binding]; other site
365044009589	substrate binding site [chemical binding]; other site
365044009590	active site
365044009591	Protein of unknown function, DUF655; Region: DUF655; pfam04919
365044009592	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
365044009593	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
365044009594	NAD(P) binding site [chemical binding]; other site
365044009595	homotetramer interface [polypeptide binding]; other site
365044009596	homodimer interface [polypeptide binding]; other site
365044009597	active site
365044009598	putative acyltransferase; Provisional; Region: PRK05790
365044009599	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044009600	dimer interface [polypeptide binding]; other site
365044009601	active site
365044009602	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
365044009603	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
365044009604	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
365044009605	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
365044009606	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
365044009607	maleylacetoacetate isomerase; Region: maiA; TIGR01262
365044009608	C-terminal domain interface [polypeptide binding]; other site
365044009609	GSH binding site (G-site) [chemical binding]; other site
365044009610	putative dimer interface [polypeptide binding]; other site
365044009611	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
365044009612	dimer interface [polypeptide binding]; other site
365044009613	N-terminal domain interface [polypeptide binding]; other site
365044009614	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
365044009615	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
365044009616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009617	PAS fold; Region: PAS_3; pfam08447
365044009618	putative active site [active]
365044009619	heme pocket [chemical binding]; other site
365044009620	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
365044009621	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
365044009622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044009623	NMT1-like family; Region: NMT1_2; cl15260
365044009624	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044009625	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
365044009626	nudix motif; other site
365044009627	Putative exonuclease, RdgC; Region: RdgC; cl01122
365044009628	PAS fold; Region: PAS_4; pfam08448
365044009629	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
365044009630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044009631	Walker A motif; other site
365044009632	ATP binding site [chemical binding]; other site
365044009633	Walker B motif; other site
365044009634	arginine finger; other site
365044009635	Helix-turn-helix domains; Region: HTH; cl00088
365044009636	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044009637	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
365044009638	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044009639	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044009640	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
365044009641	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
365044009642	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044009643	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044009644	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044009645	Cytochrome c [Energy production and conversion]; Region: COG3258
365044009646	Cytochrome c; Region: Cytochrom_C; cl11414
365044009647	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044009648	dimerization interface [polypeptide binding]; other site
365044009649	putative DNA binding site [nucleotide binding]; other site
365044009650	putative Zn2+ binding site [ion binding]; other site
365044009651	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044009652	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044009653	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044009654	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044009655	Protein export membrane protein; Region: SecD_SecF; cl14618
365044009656	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
365044009657	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
365044009658	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
365044009659	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
365044009660	active site residue [active]
365044009661	OsmC-like protein; Region: OsmC; cl00767
365044009662	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044009663	active site residue [active]
365044009664	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044009665	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044009666	Walker A/P-loop; other site
365044009667	ATP binding site [chemical binding]; other site
365044009668	Q-loop/lid; other site
365044009669	ABC transporter signature motif; other site
365044009670	Walker B; other site
365044009671	D-loop; other site
365044009672	H-loop/switch region; other site
365044009673	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044009674	FtsX-like permease family; Region: FtsX; cl15850
365044009675	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044009676	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044009677	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044009678	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
365044009679	Cation efflux family; Region: Cation_efflux; cl00316
365044009680	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
365044009681	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
365044009682	metal binding site [ion binding]; metal-binding site
365044009683	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
365044009684	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044009685	Predicted permeases [General function prediction only]; Region: COG0701
365044009686	Predicted permease; Region: DUF318; pfam03773
365044009687	RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959
365044009688	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044009689	HsdM N-terminal domain; Region: HsdM_N; pfam12161
365044009690	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
365044009691	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
365044009692	DNA binding residues [nucleotide binding]
365044009693	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
365044009694	IHF - DNA interface [nucleotide binding]; other site
365044009695	IHF dimer interface [polypeptide binding]; other site
365044009696	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
365044009697	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
365044009698	putative tRNA-binding site [nucleotide binding]; other site
365044009699	B3/4 domain; Region: B3_4; cl11458
365044009700	tRNA synthetase B5 domain; Region: B5; cl08394
365044009701	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
365044009702	dimer interface [polypeptide binding]; other site
365044009703	motif 1; other site
365044009704	motif 3; other site
365044009705	motif 2; other site
365044009706	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
365044009707	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
365044009708	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
365044009709	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
365044009710	dimer interface [polypeptide binding]; other site
365044009711	motif 1; other site
365044009712	active site
365044009713	motif 2; other site
365044009714	motif 3; other site
365044009715	ribosomal protein L20; Region: rpl20; CHL00068
365044009716	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
365044009717	23S rRNA binding site [nucleotide binding]; other site
365044009718	L21 binding site [polypeptide binding]; other site
365044009719	L13 binding site [polypeptide binding]; other site
365044009720	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
365044009721	translation initiation factor IF-3; Region: infC; TIGR00168
365044009722	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
365044009723	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
365044009724	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
365044009725	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
365044009726	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
365044009727	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
365044009728	active site
365044009729	dimer interface [polypeptide binding]; other site
365044009730	motif 1; other site
365044009731	motif 2; other site
365044009732	motif 3; other site
365044009733	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
365044009734	anticodon binding site; other site
365044009735	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
365044009736	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
365044009737	tetramer interface [polypeptide binding]; other site
365044009738	active site
365044009739	Mg2+/Mn2+ binding site [ion binding]; other site
365044009740	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
365044009741	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
365044009742	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
365044009743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044009744	dimer interface [polypeptide binding]; other site
365044009745	conserved gate region; other site
365044009746	putative PBP binding loops; other site
365044009747	ABC-ATPase subunit interface; other site
365044009748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044009749	dimer interface [polypeptide binding]; other site
365044009750	conserved gate region; other site
365044009751	putative PBP binding loops; other site
365044009752	ABC-ATPase subunit interface; other site
365044009753	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044009754	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
365044009755	Walker A/P-loop; other site
365044009756	ATP binding site [chemical binding]; other site
365044009757	Q-loop/lid; other site
365044009758	ABC transporter signature motif; other site
365044009759	Walker B; other site
365044009760	D-loop; other site
365044009761	H-loop/switch region; other site
365044009762	TOBE domain; Region: TOBE_2; cl01440
365044009763	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365044009764	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044009765	putative aminotransferase; Validated; Region: PRK07480
365044009766	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044009767	inhibitor-cofactor binding pocket; inhibition site
365044009768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009769	catalytic residue [active]
365044009770	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
365044009771	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
365044009772	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
365044009773	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
365044009774	Peptidase C26; Region: Peptidase_C26; pfam07722
365044009775	catalytic triad [active]
365044009776	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044009777	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044009778	DNA-binding site [nucleotide binding]; DNA binding site
365044009779	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044009780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009781	homodimer interface [polypeptide binding]; other site
365044009782	catalytic residue [active]
365044009783	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044009784	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
365044009785	EamA-like transporter family; Region: EamA; cl01037
365044009786	EamA-like transporter family; Region: EamA; cl01037
365044009787	malonyl-CoA synthase; Validated; Region: PRK07514
365044009788	AMP-binding enzyme; Region: AMP-binding; cl15778
365044009789	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044009790	enoyl-CoA hydratase; Provisional; Region: PRK06144
365044009791	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044009792	substrate binding site [chemical binding]; other site
365044009793	oxyanion hole (OAH) forming residues; other site
365044009794	trimer interface [polypeptide binding]; other site
365044009795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044009796	NMT1-like family; Region: NMT1_2; cl15260
365044009797	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
365044009798	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
365044009799	GAF domain; Region: GAF_2; pfam13185
365044009800	GAF domain; Region: GAF; cl15785
365044009801	PAS domain S-box; Region: sensory_box; TIGR00229
365044009802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044009803	PAS fold; Region: PAS_4; pfam08448
365044009804	putative active site [active]
365044009805	heme pocket [chemical binding]; other site
365044009806	hypothetical protein; Provisional; Region: PRK13560
365044009807	PAS domain S-box; Region: sensory_box; TIGR00229
365044009808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044009809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044009810	PAS domain; Region: PAS_9; pfam13426
365044009811	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
365044009812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044009813	dimer interface [polypeptide binding]; other site
365044009814	phosphorylation site [posttranslational modification]
365044009815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044009816	ATP binding site [chemical binding]; other site
365044009817	Mg2+ binding site [ion binding]; other site
365044009818	G-X-G motif; other site
365044009819	Response regulator receiver domain; Region: Response_reg; pfam00072
365044009820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044009821	active site
365044009822	phosphorylation site [posttranslational modification]
365044009823	intermolecular recognition site; other site
365044009824	dimerization interface [polypeptide binding]; other site
365044009825	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
365044009826	Helix-turn-helix domains; Region: HTH; cl00088
365044009827	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
365044009828	putative dimerization interface [polypeptide binding]; other site
365044009829	putative substrate binding pocket [chemical binding]; other site
365044009830	Dehydratase family; Region: ILVD_EDD; cl00340
365044009831	Cytochrome c; Region: Cytochrom_C; cl11414
365044009832	acetyl-CoA synthetase; Provisional; Region: PRK00174
365044009833	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
365044009834	AMP-binding enzyme; Region: AMP-binding; cl15778
365044009835	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044009836	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
365044009837	fumarate hydratase; Reviewed; Region: fumC; PRK00485
365044009838	Class II fumarases; Region: Fumarase_classII; cd01362
365044009839	active site
365044009840	tetramer interface [polypeptide binding]; other site
365044009841	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
365044009842	Fumarase C-terminus; Region: Fumerase_C; cl00795
365044009843	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
365044009844	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044009845	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
365044009846	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
365044009847	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044009848	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044009849	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
365044009850	Helix-turn-helix domains; Region: HTH; cl00088
365044009851	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
365044009852	aspartate kinase; Reviewed; Region: PRK06635
365044009853	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
365044009854	putative nucleotide binding site [chemical binding]; other site
365044009855	putative catalytic residues [active]
365044009856	putative Mg ion binding site [ion binding]; other site
365044009857	putative aspartate binding site [chemical binding]; other site
365044009858	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
365044009859	putative allosteric regulatory site; other site
365044009860	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
365044009861	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
365044009862	Ligand Binding Site [chemical binding]; other site
365044009863	TilS substrate binding domain; Region: TilS; pfam09179
365044009864	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044009865	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
365044009866	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
365044009867	endonuclease III; Region: ENDO3c; smart00478
365044009868	minor groove reading motif; other site
365044009869	helix-hairpin-helix signature motif; other site
365044009870	substrate binding pocket [chemical binding]; other site
365044009871	active site
365044009872	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
365044009873	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
365044009874	active site
365044009875	HIGH motif; other site
365044009876	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
365044009877	KMSKS motif; other site
365044009878	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
365044009879	tRNA binding surface [nucleotide binding]; other site
365044009880	anticodon binding site; other site
365044009881	TPR repeat; Region: TPR_11; pfam13414
365044009882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044009883	binding surface
365044009884	TPR motif; other site
365044009885	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
365044009886	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
365044009887	substrate binding site [chemical binding]; other site
365044009888	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
365044009889	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
365044009890	substrate binding site [chemical binding]; other site
365044009891	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
365044009892	putative active site [active]
365044009893	putative metal binding site [ion binding]; other site
365044009894	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
365044009895	Winged helix-turn helix; Region: HTH_29; pfam13551
365044009896	Helix-turn-helix domains; Region: HTH; cl00088
365044009897	Integrase core domain; Region: rve; cl01316
365044009898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044009899	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
365044009900	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
365044009901	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
365044009902	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
365044009903	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
365044009904	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
365044009905	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
365044009906	N-acetyl-D-glucosamine binding site [chemical binding]; other site
365044009907	catalytic residue [active]
365044009908	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
365044009909	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
365044009910	dimer interface [polypeptide binding]; other site
365044009911	active site
365044009912	glycine-pyridoxal phosphate binding site [chemical binding]; other site
365044009913	folate binding site [chemical binding]; other site
365044009914	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
365044009915	ATP cone domain; Region: ATP-cone; pfam03477
365044009916	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
365044009917	Type II transport protein GspH; Region: GspH; pfam12019
365044009918	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
365044009919	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
365044009920	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
365044009921	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
365044009922	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
365044009923	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
365044009924	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
365044009925	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
365044009926	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
365044009927	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
365044009928	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
365044009929	catalytic motif [active]
365044009930	Zn binding site [ion binding]; other site
365044009931	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
365044009932	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
365044009933	Lumazine binding domain; Region: Lum_binding; pfam00677
365044009934	Lumazine binding domain; Region: Lum_binding; pfam00677
365044009935	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
365044009936	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
365044009937	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
365044009938	dimerization interface [polypeptide binding]; other site
365044009939	active site
365044009940	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
365044009941	homopentamer interface [polypeptide binding]; other site
365044009942	active site
365044009943	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
365044009944	putative RNA binding site [nucleotide binding]; other site
365044009945	aminotransferase; Validated; Region: PRK07337
365044009946	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044009947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044009948	homodimer interface [polypeptide binding]; other site
365044009949	catalytic residue [active]
365044009950	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044009951	active site
365044009952	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
365044009953	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
365044009954	Gram-negative bacterial tonB protein; Region: TonB; cl10048
365044009955	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
365044009956	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
365044009957	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
365044009958	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
365044009959	generic binding surface II; other site
365044009960	generic binding surface I; other site
365044009961	rhodanese superfamily protein; Provisional; Region: PRK05320
365044009962	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
365044009963	active site residue [active]
365044009964	TIGR03440 family protein; Region: unchr_TIGR03440
365044009965	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
365044009966	Pirin-related protein [General function prediction only]; Region: COG1741
365044009967	Cupin domain; Region: Cupin_2; cl09118
365044009968	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
365044009969	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
365044009970	DoxX; Region: DoxX; cl00976
365044009971	Cupin domain; Region: Cupin_2; cl09118
365044009972	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
365044009973	Helix-turn-helix domains; Region: HTH; cl00088
365044009974	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044009975	dimerization interface [polypeptide binding]; other site
365044009976	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
365044009977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009978	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044009979	active site
365044009980	HIGH motif; other site
365044009981	nucleotide binding site [chemical binding]; other site
365044009982	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044009983	active site
365044009984	KMSKS motif; other site
365044009985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044009986	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
365044009987	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
365044009988	probable active site [active]
365044009989	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044009990	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044009991	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044009992	catalytic residues [active]
365044009993	3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279
365044009994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044009995	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044009996	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044009997	enoyl-CoA hydratase; Provisional; Region: PRK05995
365044009998	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044009999	substrate binding site [chemical binding]; other site
365044010000	oxyanion hole (OAH) forming residues; other site
365044010001	trimer interface [polypeptide binding]; other site
365044010002	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
365044010003	4Fe-4S binding domain; Region: Fer4; cl02805
365044010004	4Fe-4S binding domain; Region: Fer4; cl02805
365044010005	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
365044010006	FAD binding pocket [chemical binding]; other site
365044010007	conserved FAD binding motif [chemical binding]; other site
365044010008	phosphate binding motif [ion binding]; other site
365044010009	beta-alpha-beta structure motif; other site
365044010010	NAD binding pocket [chemical binding]; other site
365044010011	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
365044010012	benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184
365044010013	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044010014	substrate binding site [chemical binding]; other site
365044010015	oxyanion hole (OAH) forming residues; other site
365044010016	trimer interface [polypeptide binding]; other site
365044010017	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
365044010018	oxyanion hole (OAH) forming residues; other site
365044010019	trimer interface [polypeptide binding]; other site
365044010020	anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154
365044010021	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044010022	non-specific DNA binding site [nucleotide binding]; other site
365044010023	salt bridge; other site
365044010024	sequence-specific DNA binding site [nucleotide binding]; other site
365044010025	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
365044010026	ADP binding site [chemical binding]; other site
365044010027	magnesium binding site [ion binding]; other site
365044010028	putative shikimate binding site; other site
365044010029	aldehyde dehydrogenase; Provisional; Region: PRK11903
365044010030	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044010031	NAD(P) binding site [chemical binding]; other site
365044010032	catalytic residues [active]
365044010033	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
365044010034	AMP-binding enzyme; Region: AMP-binding; cl15778
365044010035	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044010036	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044010037	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044010038	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
365044010039	putative ligand binding site [chemical binding]; other site
365044010040	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044010041	TM-ABC transporter signature motif; other site
365044010042	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044010043	TM-ABC transporter signature motif; other site
365044010044	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044010045	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044010046	Walker A/P-loop; other site
365044010047	ATP binding site [chemical binding]; other site
365044010048	Q-loop/lid; other site
365044010049	ABC transporter signature motif; other site
365044010050	Walker B; other site
365044010051	D-loop; other site
365044010052	H-loop/switch region; other site
365044010053	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044010054	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044010055	Walker A/P-loop; other site
365044010056	ATP binding site [chemical binding]; other site
365044010057	Q-loop/lid; other site
365044010058	ABC transporter signature motif; other site
365044010059	Walker B; other site
365044010060	D-loop; other site
365044010061	H-loop/switch region; other site
365044010062	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
365044010063	Found in ATP-dependent protease La (LON); Region: LON; smart00464
365044010064	Found in ATP-dependent protease La (LON); Region: LON; smart00464
365044010065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010066	Walker A motif; other site
365044010067	ATP binding site [chemical binding]; other site
365044010068	Walker B motif; other site
365044010069	arginine finger; other site
365044010070	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
365044010071	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
365044010072	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
365044010073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010074	Walker A motif; other site
365044010075	ATP binding site [chemical binding]; other site
365044010076	Walker B motif; other site
365044010077	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
365044010078	Clp protease; Region: CLP_protease; pfam00574
365044010079	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
365044010080	oligomer interface [polypeptide binding]; other site
365044010081	active site residues [active]
365044010082	trigger factor; Provisional; Region: tig; PRK01490
365044010083	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
365044010084	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
365044010085	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044010086	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010087	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044010088	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044010089	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
365044010090	active site lid residues [active]
365044010091	substrate binding pocket [chemical binding]; other site
365044010092	catalytic residues [active]
365044010093	substrate-Mg2+ binding site; other site
365044010094	aspartate-rich region 1; other site
365044010095	aspartate-rich region 2; other site
365044010096	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
365044010097	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
365044010098	DEAD-like helicases superfamily; Region: DEXDc; smart00487
365044010099	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
365044010100	ATP binding site [chemical binding]; other site
365044010101	putative Mg++ binding site [ion binding]; other site
365044010102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044010103	nucleotide binding region [chemical binding]; other site
365044010104	ATP-binding site [chemical binding]; other site
365044010105	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
365044010106	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
365044010107	catalytic residues [active]
365044010108	substrate binding pocket [chemical binding]; other site
365044010109	substrate-Mg2+ binding site; other site
365044010110	aspartate-rich region 1; other site
365044010111	aspartate-rich region 2; other site
365044010112	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
365044010113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010114	MltA-interacting protein MipA; Region: MipA; cl01504
365044010115	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044010116	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044010117	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044010118	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044010119	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
365044010120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044010121	active site
365044010122	phosphorylation site [posttranslational modification]
365044010123	intermolecular recognition site; other site
365044010124	dimerization interface [polypeptide binding]; other site
365044010125	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044010126	DNA binding site [nucleotide binding]
365044010127	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044010128	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044010129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044010130	dimer interface [polypeptide binding]; other site
365044010131	phosphorylation site [posttranslational modification]
365044010132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044010133	ATP binding site [chemical binding]; other site
365044010134	Mg2+ binding site [ion binding]; other site
365044010135	G-X-G motif; other site
365044010136	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
365044010137	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044010138	ferrochelatase; Reviewed; Region: hemH; PRK00035
365044010139	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
365044010140	C-terminal domain interface [polypeptide binding]; other site
365044010141	active site
365044010142	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
365044010143	active site
365044010144	N-terminal domain interface [polypeptide binding]; other site
365044010145	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
365044010146	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044010147	motif II; other site
365044010148	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
365044010149	putative active site [active]
365044010150	putative catalytic site [active]
365044010151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044010152	putative substrate translocation pore; other site
365044010153	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044010154	Transcriptional regulators [Transcription]; Region: MarR; COG1846
365044010155	Helix-turn-helix domains; Region: HTH; cl00088
365044010156	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044010157	CoenzymeA binding site [chemical binding]; other site
365044010158	subunit interaction site [polypeptide binding]; other site
365044010159	PHB binding site; other site
365044010160	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
365044010161	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010162	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
365044010163	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
365044010164	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
365044010165	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
365044010166	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044010167	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
365044010168	dimer interface [polypeptide binding]; other site
365044010169	active site
365044010170	metal binding site [ion binding]; metal-binding site
365044010171	glutathione binding site [chemical binding]; other site
365044010172	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
365044010173	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
365044010174	active site
365044010175	intersubunit interface [polypeptide binding]; other site
365044010176	catalytic residue [active]
365044010177	Dehydratase family; Region: ILVD_EDD; cl00340
365044010178	6-phosphogluconate dehydratase; Region: edd; TIGR01196
365044010179	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
365044010180	ligand binding site [chemical binding]; other site
365044010181	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
365044010182	putative active site pocket [active]
365044010183	dimerization interface [polypeptide binding]; other site
365044010184	putative catalytic residue [active]
365044010185	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
365044010186	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
365044010187	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
365044010188	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
365044010189	catalytic center binding site [active]
365044010190	ATP binding site [chemical binding]; other site
365044010191	poly(A) polymerase; Region: pcnB; TIGR01942
365044010192	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
365044010193	active site
365044010194	NTP binding site [chemical binding]; other site
365044010195	metal binding triad [ion binding]; metal-binding site
365044010196	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
365044010197	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
365044010198	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
365044010199	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044010200	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010201	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
365044010202	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
365044010203	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
365044010204	dimerization interface [polypeptide binding]; other site
365044010205	putative ATP binding site [chemical binding]; other site
365044010206	Winged helix-turn helix; Region: HTH_29; pfam13551
365044010207	Helix-turn-helix domains; Region: HTH; cl00088
365044010208	Integrase core domain; Region: rve; cl01316
365044010209	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
365044010210	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044010211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044010212	Major Facilitator Superfamily; Region: MFS_1; pfam07690
365044010213	putative substrate translocation pore; other site
365044010214	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
365044010215	catalytic triad [active]
365044010216	conserved cis-peptide bond; other site
365044010217	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
365044010218	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
365044010219	conserved cys residue [active]
365044010220	Uncharacterized conserved protein [Function unknown]; Region: COG2912
365044010221	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
365044010222	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
365044010223	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
365044010224	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
365044010225	N-terminal plug; other site
365044010226	ligand-binding site [chemical binding]; other site
365044010227	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044010228	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
365044010229	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
365044010230	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
365044010231	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
365044010232	Trp docking motif [polypeptide binding]; other site
365044010233	active site
365044010234	Cytochrome c; Region: Cytochrom_C; cl11414
365044010235	Cytochrome c; Region: Cytochrom_C; cl11414
365044010236	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
365044010237	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
365044010238	acetylornithine aminotransferase; Provisional; Region: PRK02627
365044010239	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044010240	inhibitor-cofactor binding pocket; inhibition site
365044010241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010242	catalytic residue [active]
365044010243	ornithine carbamoyltransferase; Provisional; Region: PRK00779
365044010244	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
365044010245	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010246	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044010247	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044010248	NAD(P) binding site [chemical binding]; other site
365044010249	catalytic residues [active]
365044010250	Protein of unknown function (DUF779); Region: DUF779; cl01432
365044010251	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
365044010252	classical (c) SDRs; Region: SDR_c; cd05233
365044010253	NAD(P) binding site [chemical binding]; other site
365044010254	active site
365044010255	Putative cyclase; Region: Cyclase; cl00814
365044010256	kynureninase; Region: kynureninase; TIGR01814
365044010257	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044010258	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044010259	catalytic residue [active]
365044010260	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
365044010261	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
365044010262	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
365044010263	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
365044010264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010265	salicylate hydroxylase; Provisional; Region: PRK08163
365044010266	aconitate hydratase; Provisional; Region: acnA; PRK12881
365044010267	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
365044010268	substrate binding site [chemical binding]; other site
365044010269	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
365044010270	ligand binding site [chemical binding]; other site
365044010271	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
365044010272	substrate binding site [chemical binding]; other site
365044010273	putative protease; Provisional; Region: PRK15452
365044010274	Peptidase family U32; Region: Peptidase_U32; cl03113
365044010275	Transposase IS200 like; Region: Y1_Tnp; cl00848
365044010276	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
365044010277	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
365044010278	substrate binding site [chemical binding]; other site
365044010279	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
365044010280	substrate binding site [chemical binding]; other site
365044010281	ligand binding site [chemical binding]; other site
365044010282	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044010283	malate dehydrogenase; Provisional; Region: PRK05442
365044010284	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
365044010285	NAD(P) binding site [chemical binding]; other site
365044010286	dimer interface [polypeptide binding]; other site
365044010287	malate binding site [chemical binding]; other site
365044010288	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
365044010289	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044010290	DNA-binding site [nucleotide binding]; DNA binding site
365044010291	UTRA domain; Region: UTRA; cl01230
365044010292	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
365044010293	Iron-sulfur protein interface; other site
365044010294	proximal quinone binding site [chemical binding]; other site
365044010295	SdhD (CybS) interface [polypeptide binding]; other site
365044010296	proximal heme binding site [chemical binding]; other site
365044010297	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
365044010298	SdhC subunit interface [polypeptide binding]; other site
365044010299	proximal heme binding site [chemical binding]; other site
365044010300	cardiolipin binding site; other site
365044010301	Iron-sulfur protein interface; other site
365044010302	proximal quinone binding site [chemical binding]; other site
365044010303	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
365044010304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010305	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
365044010306	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
365044010307	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
365044010308	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
365044010309	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
365044010310	dimer interface [polypeptide binding]; other site
365044010311	Citrate synthase; Region: Citrate_synt; pfam00285
365044010312	active site
365044010313	citrylCoA binding site [chemical binding]; other site
365044010314	NADH binding [chemical binding]; other site
365044010315	cationic pore residues; other site
365044010316	oxalacetate/citrate binding site [chemical binding]; other site
365044010317	coenzyme A binding site [chemical binding]; other site
365044010318	catalytic triad [active]
365044010319	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044010320	Helix-turn-helix domains; Region: HTH; cl00088
365044010321	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
365044010322	putative dimerization interface [polypeptide binding]; other site
365044010323	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
365044010324	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
365044010325	substrate binding site [chemical binding]; other site
365044010326	ligand binding site [chemical binding]; other site
365044010327	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
365044010328	substrate binding site [chemical binding]; other site
365044010329	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
365044010330	tartrate dehydrogenase; Provisional; Region: PRK08194
365044010331	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
365044010332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010333	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
365044010334	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
365044010335	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
365044010336	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
365044010337	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
365044010338	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
365044010339	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
365044010340	dimerization interface 3.5A [polypeptide binding]; other site
365044010341	active site
365044010342	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
365044010343	active site
365044010344	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
365044010345	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
365044010346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010347	catalytic residue [active]
365044010348	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
365044010349	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
365044010350	substrate binding site [chemical binding]; other site
365044010351	active site
365044010352	catalytic residues [active]
365044010353	heterodimer interface [polypeptide binding]; other site
365044010354	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
365044010355	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
365044010356	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
365044010357	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
365044010358	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
365044010359	dimer interface [polypeptide binding]; other site
365044010360	putative anticodon binding site; other site
365044010361	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
365044010362	motif 1; other site
365044010363	active site
365044010364	motif 2; other site
365044010365	motif 3; other site
365044010366	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
365044010367	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
365044010368	active site
365044010369	nucleophile elbow; other site
365044010370	Protein of unknown function DUF45; Region: DUF45; cl00636
365044010371	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
365044010372	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
365044010373	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
365044010374	active site
365044010375	hydrophilic channel; other site
365044010376	dimerization interface [polypeptide binding]; other site
365044010377	catalytic residues [active]
365044010378	active site lid [active]
365044010379	Recombination protein O N terminal; Region: RecO_N; cl15812
365044010380	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
365044010381	Recombination protein O C terminal; Region: RecO_C; pfam02565
365044010382	GTPase Era; Reviewed; Region: era; PRK00089
365044010383	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
365044010384	G1 box; other site
365044010385	GTP/Mg2+ binding site [chemical binding]; other site
365044010386	Switch I region; other site
365044010387	G2 box; other site
365044010388	Switch II region; other site
365044010389	G3 box; other site
365044010390	G4 box; other site
365044010391	G5 box; other site
365044010392	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
365044010393	ribonuclease III; Reviewed; Region: rnc; PRK00102
365044010394	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
365044010395	dimerization interface [polypeptide binding]; other site
365044010396	active site
365044010397	metal binding site [ion binding]; metal-binding site
365044010398	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
365044010399	dsRNA binding site [nucleotide binding]; other site
365044010400	signal peptidase I; Provisional; Region: PRK10861
365044010401	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
365044010402	Catalytic site [active]
365044010403	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
365044010404	GTP-binding protein LepA; Provisional; Region: PRK05433
365044010405	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
365044010406	G1 box; other site
365044010407	putative GEF interaction site [polypeptide binding]; other site
365044010408	GTP/Mg2+ binding site [chemical binding]; other site
365044010409	Switch I region; other site
365044010410	G2 box; other site
365044010411	G3 box; other site
365044010412	Switch II region; other site
365044010413	G4 box; other site
365044010414	G5 box; other site
365044010415	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
365044010416	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
365044010417	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
365044010418	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
365044010419	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
365044010420	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044010421	protein binding site [polypeptide binding]; other site
365044010422	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044010423	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
365044010424	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
365044010425	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
365044010426	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
365044010427	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
365044010428	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
365044010429	DNA binding residues [nucleotide binding]
365044010430	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
365044010431	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
365044010432	dimer interface [polypeptide binding]; other site
365044010433	active site
365044010434	Phosphopantetheine attachment site; Region: PP-binding; cl09936
365044010435	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
365044010436	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010437	NAD(P) binding site [chemical binding]; other site
365044010438	active site
365044010439	Acyl transferase domain; Region: Acyl_transf_1; cl08282
365044010440	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
365044010441	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922
365044010442	BNR repeat-like domain; Region: BNR_2; pfam13088
365044010443	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
365044010444	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
365044010445	dimer interface [polypeptide binding]; other site
365044010446	active site
365044010447	CoA binding pocket [chemical binding]; other site
365044010448	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
365044010449	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
365044010450	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
365044010451	Maf-like protein; Region: Maf; pfam02545
365044010452	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
365044010453	active site
365044010454	dimer interface [polypeptide binding]; other site
365044010455	Predicted methyltransferases [General function prediction only]; Region: COG0313
365044010456	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
365044010457	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
365044010458	tandem repeat interface [polypeptide binding]; other site
365044010459	oligomer interface [polypeptide binding]; other site
365044010460	active site residues [active]
365044010461	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
365044010462	iron-sulfur cluster [ion binding]; other site
365044010463	[2Fe-2S] cluster binding site [ion binding]; other site
365044010464	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
365044010465	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044010466	motif II; other site
365044010467	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
365044010468	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
365044010469	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
365044010470	active site
365044010471	ribonuclease E; Reviewed; Region: rne; PRK10811
365044010472	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
365044010473	homodimer interface [polypeptide binding]; other site
365044010474	oligonucleotide binding site [chemical binding]; other site
365044010475	hemY protein; Region: hemY_coli; TIGR00540
365044010476	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
365044010477	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
365044010478	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
365044010479	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
365044010480	active site
365044010481	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
365044010482	domain interfaces; other site
365044010483	active site
365044010484	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
365044010485	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
365044010486	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
365044010487	Putative glucoamylase; Region: Glycoamylase; pfam10091
365044010488	Putative carbohydrate binding domain; Region: CBM_X; cl05621
365044010489	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
365044010490	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
365044010491	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
365044010492	Putative carbohydrate binding domain; Region: CBM_X; cl05621
365044010493	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
365044010494	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
365044010495	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
365044010496	putative active site [active]
365044010497	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
365044010498	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
365044010499	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
365044010500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044010501	active site
365044010502	phosphorylation site [posttranslational modification]
365044010503	intermolecular recognition site; other site
365044010504	dimerization interface [polypeptide binding]; other site
365044010505	LytTr DNA-binding domain; Region: LytTR; cl04498
365044010506	Histidine kinase; Region: His_kinase; pfam06580
365044010507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044010508	argininosuccinate lyase; Provisional; Region: PRK00855
365044010509	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
365044010510	active sites [active]
365044010511	tetramer interface [polypeptide binding]; other site
365044010512	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
365044010513	Protein of unknown function (DUF497); Region: DUF497; cl01108
365044010514	Phasin protein; Region: Phasin_2; cl11491
365044010515	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
365044010516	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
365044010517	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010518	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
365044010519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044010520	active site
365044010521	phosphorylation site [posttranslational modification]
365044010522	intermolecular recognition site; other site
365044010523	dimerization interface [polypeptide binding]; other site
365044010524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044010525	DNA binding site [nucleotide binding]
365044010526	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044010527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044010528	dimer interface [polypeptide binding]; other site
365044010529	phosphorylation site [posttranslational modification]
365044010530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044010531	ATP binding site [chemical binding]; other site
365044010532	G-X-G motif; other site
365044010533	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
365044010534	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
365044010535	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044010536	protein binding site [polypeptide binding]; other site
365044010537	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
365044010538	protein binding site [polypeptide binding]; other site
365044010539	Transposase; Region: DEDD_Tnp_IS110; pfam01548
365044010540	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
365044010541	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
365044010542	MG2 domain; Region: A2M_N; pfam01835
365044010543	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
365044010544	Alpha-2-macroglobulin family; Region: A2M; pfam00207
365044010545	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
365044010546	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
365044010547	Bacterial sugar transferase; Region: Bac_transf; cl00939
365044010548	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
365044010549	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
365044010550	NAD(P) binding site [chemical binding]; other site
365044010551	homodimer interface [polypeptide binding]; other site
365044010552	substrate binding site [chemical binding]; other site
365044010553	active site
365044010554	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
365044010555	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365044010556	inhibitor-cofactor binding pocket; inhibition site
365044010557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010558	catalytic residue [active]
365044010559	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044010560	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
365044010561	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
365044010562	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
365044010563	Ligand Binding Site [chemical binding]; other site
365044010564	imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033
365044010565	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
365044010566	substrate binding site [chemical binding]; other site
365044010567	glutamase interaction surface [polypeptide binding]; other site
365044010568	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
365044010569	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
365044010570	putative active site [active]
365044010571	oxyanion strand; other site
365044010572	catalytic triad [active]
365044010573	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
365044010574	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
365044010575	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
365044010576	inhibitor-cofactor binding pocket; inhibition site
365044010577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010578	catalytic residue [active]
365044010579	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
365044010580	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
365044010581	putative trimer interface [polypeptide binding]; other site
365044010582	putative active site [active]
365044010583	putative substrate binding site [chemical binding]; other site
365044010584	putative CoA binding site [chemical binding]; other site
365044010585	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
365044010586	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010587	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
365044010588	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
365044010589	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
365044010590	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
365044010591	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010592	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
365044010593	Mg++ binding site [ion binding]; other site
365044010594	putative catalytic motif [active]
365044010595	tyrosine kinase; Provisional; Region: PRK11519
365044010596	Chain length determinant protein; Region: Wzz; cl15801
365044010597	Chain length determinant protein; Region: Wzz; cl15801
365044010598	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044010599	P loop; other site
365044010600	Nucleotide binding site [chemical binding]; other site
365044010601	DTAP/Switch II; other site
365044010602	Switch I; other site
365044010603	polysaccharide export protein Wza; Provisional; Region: PRK15078
365044010604	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
365044010605	SLBB domain; Region: SLBB; pfam10531
365044010606	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
365044010607	transcriptional activator RfaH; Region: RfaH; TIGR01955
365044010608	Sel1 repeat; Region: Sel1; cl02723
365044010609	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
365044010610	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
365044010611	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
365044010612	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044010613	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
365044010614	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010615	Walker A motif; other site
365044010616	ATP binding site [chemical binding]; other site
365044010617	Walker B motif; other site
365044010618	arginine finger; other site
365044010619	tellurium resistance terB-like protein; Region: terB_like; cl11965
365044010620	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
365044010621	Transglycosylase; Region: Transgly; cl07896
365044010622	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044010623	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
365044010624	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044010625	Helix-turn-helix domains; Region: HTH; cl00088
365044010626	salicylate hydroxylase; Provisional; Region: PRK08163
365044010627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010628	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
365044010629	Cupin domain; Region: Cupin_2; cl09118
365044010630	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
365044010631	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
365044010632	maleylacetoacetate isomerase; Region: maiA; TIGR01262
365044010633	C-terminal domain interface [polypeptide binding]; other site
365044010634	GSH binding site (G-site) [chemical binding]; other site
365044010635	putative dimer interface [polypeptide binding]; other site
365044010636	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
365044010637	dimer interface [polypeptide binding]; other site
365044010638	N-terminal domain interface [polypeptide binding]; other site
365044010639	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
365044010640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044010641	NMT1-like family; Region: NMT1_2; cl15260
365044010642	Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236
365044010643	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010644	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044010645	Probable transposase; Region: OrfB_IS605; pfam01385
365044010646	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044010647	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044010648	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365044010649	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010650	Walker A motif; other site
365044010651	ATP binding site [chemical binding]; other site
365044010652	Walker B motif; other site
365044010653	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044010654	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365044010655	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010656	Walker A motif; other site
365044010657	ATP binding site [chemical binding]; other site
365044010658	Walker B motif; other site
365044010659	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
365044010660	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
365044010661	active site
365044010662	substrate binding site [chemical binding]; other site
365044010663	FMN binding site [chemical binding]; other site
365044010664	putative catalytic residues [active]
365044010665	Cytochrome c; Region: Cytochrom_C; cl11414
365044010666	Cytochrome c; Region: Cytochrom_C; cl11414
365044010667	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044010668	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044010669	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
365044010670	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
365044010671	active site
365044010672	DNA polymerase IV; Validated; Region: PRK02406
365044010673	DNA binding site [nucleotide binding]
365044010674	PAS domain; Region: PAS_9; pfam13426
365044010675	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044010676	putative active site [active]
365044010677	heme pocket [chemical binding]; other site
365044010678	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044010679	dimer interface [polypeptide binding]; other site
365044010680	phosphorylation site [posttranslational modification]
365044010681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044010682	ATP binding site [chemical binding]; other site
365044010683	Mg2+ binding site [ion binding]; other site
365044010684	G-X-G motif; other site
365044010685	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
365044010686	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
365044010687	apolar tunnel; other site
365044010688	heme binding site [chemical binding]; other site
365044010689	dimerization interface [polypeptide binding]; other site
365044010690	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
365044010691	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
365044010692	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
365044010693	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044010694	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044010695	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044010696	Protein of unknown function (DUF328); Region: DUF328; cl01143
365044010697	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044010698	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044010699	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044010700	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044010701	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
365044010702	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044010703	active site
365044010704	HIGH motif; other site
365044010705	nucleotide binding site [chemical binding]; other site
365044010706	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
365044010707	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
365044010708	active site
365044010709	KMSKS motif; other site
365044010710	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
365044010711	tRNA binding surface [nucleotide binding]; other site
365044010712	anticodon binding site; other site
365044010713	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
365044010714	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
365044010715	CPxP  motif; other site
365044010716	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044010717	nudix motif; other site
365044010718	cysteine synthase B; Region: cysM; TIGR01138
365044010719	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365044010720	dimer interface [polypeptide binding]; other site
365044010721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044010722	catalytic residue [active]
365044010723	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044010724	Probable transposase; Region: OrfB_IS605; pfam01385
365044010725	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044010726	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
365044010727	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
365044010728	active site
365044010729	GDP-Mannose binding site [chemical binding]; other site
365044010730	modified nudix motif
365044010731	dimer interface [polypeptide binding]; other site
365044010732	metal binding site [ion binding]; metal-binding site
365044010733	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
365044010734	active site
365044010735	tetramer interface; other site
365044010736	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
365044010737	Bacterial sugar transferase; Region: Bac_transf; cl00939
365044010738	putative glycosyl transferase; Provisional; Region: PRK10307
365044010739	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
365044010740	OpgC protein; Region: OpgC_C; cl00792
365044010741	Acyltransferase family; Region: Acyl_transf_3; pfam01757
365044010742	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
365044010743	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
365044010744	putative metal binding site; other site
365044010745	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
365044010746	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
365044010747	putative trimer interface [polypeptide binding]; other site
365044010748	putative active site [active]
365044010749	putative substrate binding site [chemical binding]; other site
365044010750	putative CoA binding site [chemical binding]; other site
365044010751	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044010752	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
365044010753	putative ADP-binding pocket [chemical binding]; other site
365044010754	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
365044010755	putative trimer interface [polypeptide binding]; other site
365044010756	putative CoA binding site [chemical binding]; other site
365044010757	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
365044010758	metal-binding site
365044010759	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
365044010760	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
365044010761	active site
365044010762	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
365044010763	MatE; Region: MatE; cl10513
365044010764	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
365044010765	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
365044010766	NADP-binding site; other site
365044010767	homotetramer interface [polypeptide binding]; other site
365044010768	substrate binding site [chemical binding]; other site
365044010769	homodimer interface [polypeptide binding]; other site
365044010770	active site
365044010771	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
365044010772	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
365044010773	NADP binding site [chemical binding]; other site
365044010774	active site
365044010775	putative substrate binding site [chemical binding]; other site
365044010776	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
365044010777	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
365044010778	Substrate binding site; other site
365044010779	Cupin domain; Region: Cupin_2; cl09118
365044010780	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
365044010781	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
365044010782	catalytic residue [active]
365044010783	putative FPP diphosphate  binding site; other site
365044010784	putative FPP binding hydrophobic cleft; other site
365044010785	dimer interface [polypeptide binding]; other site
365044010786	putative IPP diphosphate binding site; other site
365044010787	tyrosine kinase; Provisional; Region: PRK11519
365044010788	Chain length determinant protein; Region: Wzz; cl15801
365044010789	Chain length determinant protein; Region: Wzz; cl15801
365044010790	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044010791	P loop; other site
365044010792	Nucleotide binding site [chemical binding]; other site
365044010793	DTAP/Switch II; other site
365044010794	Switch I; other site
365044010795	Low molecular weight phosphatase family; Region: LMWPc; cd00115
365044010796	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
365044010797	active site
365044010798	polysaccharide export protein Wza; Provisional; Region: PRK15078
365044010799	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
365044010800	SLBB domain; Region: SLBB; pfam10531
365044010801	SLBB domain; Region: SLBB; pfam10531
365044010802	transcriptional activator RfaH; Region: RfaH; TIGR01955
365044010803	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
365044010804	Domain of unknown function DUF21; Region: DUF21; pfam01595
365044010805	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
365044010806	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
365044010807	Transporter associated domain; Region: CorC_HlyC; cl08393
365044010808	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
365044010809	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
365044010810	active site
365044010811	metal binding site [ion binding]; metal-binding site
365044010812	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
365044010813	helicase 45; Provisional; Region: PTZ00424
365044010814	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044010815	ATP binding site [chemical binding]; other site
365044010816	Mg++ binding site [ion binding]; other site
365044010817	motif III; other site
365044010818	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044010819	nucleotide binding region [chemical binding]; other site
365044010820	ATP-binding site [chemical binding]; other site
365044010821	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044010822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044010823	NAD(P) binding site [chemical binding]; other site
365044010824	active site
365044010825	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
365044010826	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
365044010827	catalytic loop [active]
365044010828	iron binding site [ion binding]; other site
365044010829	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
365044010830	FAD binding pocket [chemical binding]; other site
365044010831	FAD binding motif [chemical binding]; other site
365044010832	phosphate binding motif [ion binding]; other site
365044010833	beta-alpha-beta structure motif; other site
365044010834	NAD binding pocket [chemical binding]; other site
365044010835	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044010836	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044010837	Walker A/P-loop; other site
365044010838	ATP binding site [chemical binding]; other site
365044010839	Q-loop/lid; other site
365044010840	ABC transporter signature motif; other site
365044010841	Walker B; other site
365044010842	D-loop; other site
365044010843	H-loop/switch region; other site
365044010844	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044010845	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044010846	Walker A/P-loop; other site
365044010847	ATP binding site [chemical binding]; other site
365044010848	Q-loop/lid; other site
365044010849	ABC transporter signature motif; other site
365044010850	Walker B; other site
365044010851	D-loop; other site
365044010852	H-loop/switch region; other site
365044010853	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044010854	TM-ABC transporter signature motif; other site
365044010855	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044010856	TM-ABC transporter signature motif; other site
365044010857	recombination factor protein RarA; Reviewed; Region: PRK13342
365044010858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010859	Walker A motif; other site
365044010860	ATP binding site [chemical binding]; other site
365044010861	Walker B motif; other site
365044010862	arginine finger; other site
365044010863	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
365044010864	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
365044010865	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
365044010866	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
365044010867	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044010868	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
365044010869	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044010870	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044010871	ligand binding site [chemical binding]; other site
365044010872	flexible hinge region; other site
365044010873	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044010874	non-specific DNA interactions [nucleotide binding]; other site
365044010875	DNA binding site [nucleotide binding]
365044010876	sequence specific DNA binding site [nucleotide binding]; other site
365044010877	putative cAMP binding site [chemical binding]; other site
365044010878	thioredoxin reductase; Provisional; Region: PRK10262
365044010879	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044010880	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
365044010881	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
365044010882	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
365044010883	Di-iron ligands [ion binding]; other site
365044010884	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
365044010885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044010886	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
365044010887	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
365044010888	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
365044010889	G1 box; other site
365044010890	putative GEF interaction site [polypeptide binding]; other site
365044010891	GTP/Mg2+ binding site [chemical binding]; other site
365044010892	Switch I region; other site
365044010893	G2 box; other site
365044010894	G3 box; other site
365044010895	Switch II region; other site
365044010896	G4 box; other site
365044010897	G5 box; other site
365044010898	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
365044010899	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
365044010900	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044010901	Helix-turn-helix domains; Region: HTH; cl00088
365044010902	AsnC family; Region: AsnC_trans_reg; pfam01037
365044010903	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
365044010904	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
365044010905	active site
365044010906	substrate binding site [chemical binding]; other site
365044010907	cosubstrate binding site; other site
365044010908	catalytic site [active]
365044010909	hypothetical protein; Provisional; Region: PRK11239
365044010910	Protein of unknown function, DUF480; Region: DUF480; cl01209
365044010911	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
365044010912	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044010913	active site
365044010914	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
365044010915	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
365044010916	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
365044010917	active site
365044010918	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
365044010919	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
365044010920	active site
365044010921	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
365044010922	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
365044010923	active site
365044010924	Riboflavin kinase; Region: Flavokinase; cl03312
365044010925	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
365044010926	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044010927	active site
365044010928	HIGH motif; other site
365044010929	nucleotide binding site [chemical binding]; other site
365044010930	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
365044010931	active site
365044010932	KMSKS motif; other site
365044010933	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
365044010934	tRNA binding surface [nucleotide binding]; other site
365044010935	anticodon binding site; other site
365044010936	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
365044010937	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
365044010938	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
365044010939	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
365044010940	PhoU domain; Region: PhoU; pfam01895
365044010941	PhoU domain; Region: PhoU; pfam01895
365044010942	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
365044010943	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
365044010944	NADP binding site [chemical binding]; other site
365044010945	dimer interface [polypeptide binding]; other site
365044010946	EamA-like transporter family; Region: EamA; cl01037
365044010947	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044010948	EamA-like transporter family; Region: EamA; cl01037
365044010949	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
365044010950	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
365044010951	putative NAD(P) binding site [chemical binding]; other site
365044010952	putative active site [active]
365044010953	EamA-like transporter family; Region: EamA; cl01037
365044010954	EamA-like transporter family; Region: EamA; cl01037
365044010955	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
365044010956	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
365044010957	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
365044010958	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
365044010959	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
365044010960	Walker A motif; other site
365044010961	ATP binding site [chemical binding]; other site
365044010962	Walker B motif; other site
365044010963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044010964	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044010965	active site
365044010966	Int/Topo IB signature motif; other site
365044010967	DNA binding site [nucleotide binding]
365044010968	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
365044010969	putative active site [active]
365044010970	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
365044010971	active site
365044010972	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
365044010973	MoxR-like ATPases [General function prediction only]; Region: COG0714
365044010974	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044010975	Walker A motif; other site
365044010976	ATP binding site [chemical binding]; other site
365044010977	Walker B motif; other site
365044010978	arginine finger; other site
365044010979	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
365044010980	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044010981	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
365044010982	metal ion-dependent adhesion site (MIDAS); other site
365044010983	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
365044010984	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
365044010985	active site
365044010986	nucleophile elbow; other site
365044010987	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
365044010988	HSP70 interaction site [polypeptide binding]; other site
365044010989	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
365044010990	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044010991	Walker A/P-loop; other site
365044010992	ATP binding site [chemical binding]; other site
365044010993	Q-loop/lid; other site
365044010994	ABC transporter signature motif; other site
365044010995	Walker B; other site
365044010996	D-loop; other site
365044010997	H-loop/switch region; other site
365044010998	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
365044010999	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044011000	FtsX-like permease family; Region: FtsX; cl15850
365044011001	Sulfatase; Region: Sulfatase; cl10460
365044011002	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
365044011003	DHH family; Region: DHH; pfam01368
365044011004	DHHA1 domain; Region: DHHA1; pfam02272
365044011005	NMT1-like family; Region: NMT1_2; cl15260
365044011006	Tubulin like; Region: Tubulin_2; pfam13809
365044011007	Fic family protein [Function unknown]; Region: COG3177
365044011008	Fic/DOC family; Region: Fic; cl00960
365044011009	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365044011010	active site
365044011011	catalytic site [active]
365044011012	substrate binding site [chemical binding]; other site
365044011013	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
365044011014	HSP70 interaction site [polypeptide binding]; other site
365044011015	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
365044011016	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044011017	ligand binding site [chemical binding]; other site
365044011018	flexible hinge region; other site
365044011019	Helix-turn-helix domains; Region: HTH; cl00088
365044011020	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
365044011021	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
365044011022	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044011023	Walker A/P-loop; other site
365044011024	ATP binding site [chemical binding]; other site
365044011025	Q-loop/lid; other site
365044011026	ABC transporter signature motif; other site
365044011027	Walker B; other site
365044011028	D-loop; other site
365044011029	H-loop/switch region; other site
365044011030	TOBE domain; Region: TOBE_2; cl01440
365044011031	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
365044011032	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044011033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044011034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011035	dimer interface [polypeptide binding]; other site
365044011036	conserved gate region; other site
365044011037	ABC-ATPase subunit interface; other site
365044011038	Transcriptional regulators [Transcription]; Region: GntR; COG1802
365044011039	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044011040	DNA-binding site [nucleotide binding]; DNA binding site
365044011041	FCD domain; Region: FCD; cl11656
365044011042	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
365044011043	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
365044011044	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
365044011045	EamA-like transporter family; Region: EamA; cl01037
365044011046	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
365044011047	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
365044011048	active site
365044011049	putative substrate binding region [chemical binding]; other site
365044011050	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
365044011051	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
365044011052	active site
365044011053	HIGH motif; other site
365044011054	dimer interface [polypeptide binding]; other site
365044011055	KMSKS motif; other site
365044011056	CsbD-like; Region: CsbD; cl15799
365044011057	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044011058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011059	active site
365044011060	phosphorylation site [posttranslational modification]
365044011061	intermolecular recognition site; other site
365044011062	dimerization interface [polypeptide binding]; other site
365044011063	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044011064	DNA binding site [nucleotide binding]
365044011065	PAS fold; Region: PAS_7; pfam12860
365044011066	PAS fold; Region: PAS_4; pfam08448
365044011067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044011068	putative active site [active]
365044011069	heme pocket [chemical binding]; other site
365044011070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011071	dimer interface [polypeptide binding]; other site
365044011072	phosphorylation site [posttranslational modification]
365044011073	sensory histidine kinase CreC; Provisional; Region: PRK11100
365044011074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011075	ATP binding site [chemical binding]; other site
365044011076	G-X-G motif; other site
365044011077	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011079	active site
365044011080	phosphorylation site [posttranslational modification]
365044011081	intermolecular recognition site; other site
365044011082	dimerization interface [polypeptide binding]; other site
365044011083	acyl-CoA synthetase; Validated; Region: PRK08162
365044011084	AMP-binding enzyme; Region: AMP-binding; cl15778
365044011085	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044011086	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
365044011087	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
365044011088	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
365044011089	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
365044011090	dimer interaction site [polypeptide binding]; other site
365044011091	substrate-binding tunnel; other site
365044011092	active site
365044011093	catalytic site [active]
365044011094	substrate binding site [chemical binding]; other site
365044011095	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
365044011096	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
365044011097	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044011098	active site
365044011099	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
365044011100	Protein of unknown function, DUF485; Region: DUF485; cl01231
365044011101	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
365044011102	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
365044011103	Na binding site [ion binding]; other site
365044011104	Phage-related protein [Function unknown]; Region: COG4695; cl01923
365044011105	phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540
365044011106	terminase ATPase subunit; Provisional; Region: P; PHA02535
365044011107	Helix-turn-helix domains; Region: HTH; cl00088
365044011108	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
365044011109	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
365044011110	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
365044011111	terminase endonuclease subunit; Provisional; Region: M; PHA02537
365044011112	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
365044011113	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
365044011114	Phage Tail Protein X; Region: Phage_tail_X; cl02088
365044011115	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
365044011116	catalytic residue [active]
365044011117	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
365044011118	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
365044011119	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
365044011120	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
365044011121	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
365044011122	Baseplate J-like protein; Region: Baseplate_J; cl01294
365044011123	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
365044011124	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
365044011125	oxyanion hole [active]
365044011126	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
365044011127	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
365044011128	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
365044011129	Phage Tail Collar Domain; Region: Collar; pfam07484
365044011130	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
365044011131	Phage tail tube protein FII; Region: Phage_tube; cl01390
365044011132	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
365044011133	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
365044011134	Phage-related tail protein [Function unknown]; Region: COG5283
365044011135	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
365044011136	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
365044011137	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
365044011138	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
365044011139	non-specific DNA binding site [nucleotide binding]; other site
365044011140	salt bridge; other site
365044011141	sequence-specific DNA binding site [nucleotide binding]; other site
365044011142	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
365044011143	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
365044011144	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
365044011145	WYL domain; Region: WYL; cl14852
365044011146	Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601
365044011147	Predicted transcriptional regulator [Transcription]; Region: COG2378
365044011148	Protein of unknown function (DUF1484); Region: DUF1484; pfam07363
365044011149	Helix-turn-helix domains; Region: HTH; cl00088
365044011150	Helix-turn-helix domains; Region: HTH; cl00088
365044011151	Protein of unknown function (DUF2528); Region: DUF2528; pfam10800
365044011152	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
365044011153	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044011154	integrase; Provisional; Region: PRK09692
365044011155	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
365044011156	active site
365044011157	Int/Topo IB signature motif; other site
365044011158	seryl-tRNA synthetase; Provisional; Region: PRK05431
365044011159	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
365044011160	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
365044011161	dimer interface [polypeptide binding]; other site
365044011162	active site
365044011163	motif 1; other site
365044011164	motif 2; other site
365044011165	motif 3; other site
365044011166	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
365044011167	hypothetical protein; Provisional; Region: PRK06815
365044011168	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044011169	catalytic residue [active]
365044011170	LytB protein; Region: LYTB; cl00507
365044011171	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
365044011172	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
365044011173	hypothetical protein; Reviewed; Region: PRK00024
365044011174	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
365044011175	MPN+ (JAMM) motif; other site
365044011176	Zinc-binding site [ion binding]; other site
365044011177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
365044011178	Smr domain; Region: Smr; cl02619
365044011179	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044011180	DNA binding residues [nucleotide binding]
365044011181	dimerization interface [polypeptide binding]; other site
365044011182	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
365044011183	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
365044011184	putative acyl-acceptor binding pocket; other site
365044011185	dihydroorotase; Provisional; Region: PRK07627
365044011186	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044011187	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
365044011188	active site
365044011189	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
365044011190	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
365044011191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044011192	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
365044011193	active site
365044011194	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
365044011195	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
365044011196	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
365044011197	DNA photolyase; Region: DNA_photolyase; pfam00875
365044011198	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
365044011199	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
365044011200	putative binding surface; other site
365044011201	active site
365044011202	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
365044011203	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
365044011204	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
365044011205	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
365044011206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011207	ATP binding site [chemical binding]; other site
365044011208	Mg2+ binding site [ion binding]; other site
365044011209	G-X-G motif; other site
365044011210	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
365044011211	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011213	active site
365044011214	phosphorylation site [posttranslational modification]
365044011215	intermolecular recognition site; other site
365044011216	dimerization interface [polypeptide binding]; other site
365044011217	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044011218	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
365044011219	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
365044011220	dimer interface [polypeptide binding]; other site
365044011221	putative CheW interface [polypeptide binding]; other site
365044011222	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
365044011223	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011225	active site
365044011226	phosphorylation site [posttranslational modification]
365044011227	intermolecular recognition site; other site
365044011228	dimerization interface [polypeptide binding]; other site
365044011229	Response regulator receiver domain; Region: Response_reg; pfam00072
365044011230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011231	active site
365044011232	phosphorylation site [posttranslational modification]
365044011233	intermolecular recognition site; other site
365044011234	dimerization interface [polypeptide binding]; other site
365044011235	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
365044011236	Rubredoxin; Region: Rubredoxin; pfam00301
365044011237	iron binding site [ion binding]; other site
365044011238	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
365044011239	dimer interface [polypeptide binding]; other site
365044011240	substrate binding site [chemical binding]; other site
365044011241	ATP binding site [chemical binding]; other site
365044011242	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
365044011243	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044011244	inhibitor-cofactor binding pocket; inhibition site
365044011245	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011246	catalytic residue [active]
365044011247	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
365044011248	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
365044011249	purine monophosphate binding site [chemical binding]; other site
365044011250	dimer interface [polypeptide binding]; other site
365044011251	putative catalytic residues [active]
365044011252	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
365044011253	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
365044011254	Helix-turn-helix domains; Region: HTH; cl00088
365044011255	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
365044011256	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
365044011257	FMN binding site [chemical binding]; other site
365044011258	active site
365044011259	catalytic residues [active]
365044011260	substrate binding site [chemical binding]; other site
365044011261	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
365044011262	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044011263	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044011264	RNA binding surface [nucleotide binding]; other site
365044011265	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
365044011266	active site
365044011267	GTP-binding protein YchF; Reviewed; Region: PRK09601
365044011268	YchF GTPase; Region: YchF; cd01900
365044011269	G1 box; other site
365044011270	GTP/Mg2+ binding site [chemical binding]; other site
365044011271	Switch I region; other site
365044011272	G2 box; other site
365044011273	Switch II region; other site
365044011274	G3 box; other site
365044011275	G4 box; other site
365044011276	G5 box; other site
365044011277	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
365044011278	Sulfate transporter family; Region: Sulfate_transp; cl15842
365044011279	high affinity sulphate transporter 1; Region: sulP; TIGR00815
365044011280	Sulfate transporter family; Region: Sulfate_transp; cl15842
365044011281	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
365044011282	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
365044011283	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
365044011284	MOSC domain; Region: MOSC; pfam03473
365044011285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044011286	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
365044011287	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
365044011288	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
365044011289	dimerization domain [polypeptide binding]; other site
365044011290	dimer interface [polypeptide binding]; other site
365044011291	catalytic residues [active]
365044011292	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
365044011293	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
365044011294	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
365044011295	protein binding site [polypeptide binding]; other site
365044011296	enoyl-CoA hydratase; Provisional; Region: PRK05862
365044011297	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044011298	substrate binding site [chemical binding]; other site
365044011299	oxyanion hole (OAH) forming residues; other site
365044011300	trimer interface [polypeptide binding]; other site
365044011301	Haemolysin-III related; Region: HlyIII; cl03831
365044011302	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
365044011303	Flavoprotein; Region: Flavoprotein; cl08021
365044011304	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
365044011305	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
365044011306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044011307	FeS/SAM binding site; other site
365044011308	TRAM domain; Region: TRAM; cl01282
365044011309	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044011310	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044011311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011312	dimer interface [polypeptide binding]; other site
365044011313	phosphorylation site [posttranslational modification]
365044011314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011315	ATP binding site [chemical binding]; other site
365044011316	Mg2+ binding site [ion binding]; other site
365044011317	G-X-G motif; other site
365044011318	response regulator GlrR; Provisional; Region: PRK15115
365044011319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011320	active site
365044011321	phosphorylation site [posttranslational modification]
365044011322	intermolecular recognition site; other site
365044011323	dimerization interface [polypeptide binding]; other site
365044011324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011325	Walker A motif; other site
365044011326	ATP binding site [chemical binding]; other site
365044011327	Walker B motif; other site
365044011328	arginine finger; other site
365044011329	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
365044011330	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
365044011331	Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943
365044011332	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
365044011333	Ligand binding site; other site
365044011334	DXD motif; other site
365044011335	signal recognition particle protein; Provisional; Region: PRK10867
365044011336	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
365044011337	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
365044011338	GTP binding site [chemical binding]; other site
365044011339	Signal peptide binding domain; Region: SRP_SPB; pfam02978
365044011340	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
365044011341	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
365044011342	sensory histidine kinase AtoS; Provisional; Region: PRK11360
365044011343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011344	dimer interface [polypeptide binding]; other site
365044011345	phosphorylation site [posttranslational modification]
365044011346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011347	ATP binding site [chemical binding]; other site
365044011348	Mg2+ binding site [ion binding]; other site
365044011349	G-X-G motif; other site
365044011350	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044011351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011352	active site
365044011353	phosphorylation site [posttranslational modification]
365044011354	intermolecular recognition site; other site
365044011355	dimerization interface [polypeptide binding]; other site
365044011356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044011357	Walker A motif; other site
365044011358	ATP binding site [chemical binding]; other site
365044011359	Walker B motif; other site
365044011360	arginine finger; other site
365044011361	Helix-turn-helix domains; Region: HTH; cl00088
365044011362	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
365044011363	amidase catalytic site [active]
365044011364	Zn binding residues [ion binding]; other site
365044011365	substrate binding site [chemical binding]; other site
365044011366	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
365044011367	ATP cone domain; Region: ATP-cone; pfam03477
365044011368	ATP cone domain; Region: ATP-cone; pfam03477
365044011369	Class I ribonucleotide reductase; Region: RNR_I; cd01679
365044011370	active site
365044011371	dimer interface [polypeptide binding]; other site
365044011372	catalytic residues [active]
365044011373	effector binding site; other site
365044011374	R2 peptide binding site; other site
365044011375	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
365044011376	dimer interface [polypeptide binding]; other site
365044011377	putative radical transfer pathway; other site
365044011378	diiron center [ion binding]; other site
365044011379	tyrosyl radical; other site
365044011380	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
365044011381	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
365044011382	substrate binding site [chemical binding]; other site
365044011383	ATP binding site [chemical binding]; other site
365044011384	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
365044011385	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
365044011386	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
365044011387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044011388	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
365044011389	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
365044011390	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044011391	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
365044011392	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
365044011393	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
365044011394	carboxyltransferase (CT) interaction site; other site
365044011395	biotinylation site [posttranslational modification]; other site
365044011396	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
365044011397	catalytic residues [active]
365044011398	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
365044011399	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365044011400	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011401	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044011402	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
365044011403	NeuB family; Region: NeuB; cl00496
365044011404	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
365044011405	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
365044011406	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
365044011407	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
365044011408	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
365044011409	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
365044011410	Probable transposase; Region: OrfB_IS605; pfam01385
365044011411	DDE superfamily endonuclease; Region: DDE_5; cl02413
365044011412	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044011413	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
365044011414	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
365044011415	RNB domain; Region: RNB; pfam00773
365044011416	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
365044011417	Gram-negative bacterial tonB protein; Region: TonB; cl10048
365044011418	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
365044011419	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
365044011420	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
365044011421	shikimate binding site; other site
365044011422	NAD(P) binding site [chemical binding]; other site
365044011423	Transglycosylase; Region: Transgly; cl07896
365044011424	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
365044011425	active site
365044011426	putative DNA-binding cleft [nucleotide binding]; other site
365044011427	dimer interface [polypeptide binding]; other site
365044011428	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
365044011429	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
365044011430	cell division protein FtsZ; Validated; Region: PRK09330
365044011431	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
365044011432	nucleotide binding site [chemical binding]; other site
365044011433	SulA interaction site; other site
365044011434	cell division protein FtsA; Region: ftsA; TIGR01174
365044011435	Cell division protein FtsA; Region: FtsA; cl11496
365044011436	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
365044011437	ATP binding site [chemical binding]; other site
365044011438	profilin binding site; other site
365044011439	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
365044011440	Cell division protein FtsQ; Region: FtsQ; pfam03799
365044011441	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
365044011442	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
365044011443	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044011444	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
365044011445	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365044011446	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011447	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044011448	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
365044011449	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
365044011450	active site
365044011451	homodimer interface [polypeptide binding]; other site
365044011452	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
365044011453	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
365044011454	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011455	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
365044011456	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
365044011457	Mg++ binding site [ion binding]; other site
365044011458	putative catalytic motif [active]
365044011459	putative substrate binding site [chemical binding]; other site
365044011460	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
365044011461	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
365044011462	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011463	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044011464	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
365044011465	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
365044011466	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
365044011467	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
365044011468	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
365044011469	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044011470	Septum formation initiator; Region: DivIC; cl11433
365044011471	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
365044011472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044011473	cell division protein MraZ; Reviewed; Region: PRK00326
365044011474	MraZ protein; Region: MraZ; pfam02381
365044011475	MraZ protein; Region: MraZ; pfam02381
365044011476	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
365044011477	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
365044011478	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
365044011479	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
365044011480	P-loop, Walker A motif; other site
365044011481	Base recognition motif; other site
365044011482	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
365044011483	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
365044011484	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044011485	DNA-binding site [nucleotide binding]; DNA binding site
365044011486	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
365044011487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011488	homodimer interface [polypeptide binding]; other site
365044011489	catalytic residue [active]
365044011490	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
365044011491	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
365044011492	putative RNA binding site [nucleotide binding]; other site
365044011493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044011494	S-adenosylmethionine binding site [chemical binding]; other site
365044011495	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
365044011496	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044011497	active site
365044011498	DNA binding site [nucleotide binding]
365044011499	Int/Topo IB signature motif; other site
365044011500	GAF domain; Region: GAF; cl15785
365044011501	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
365044011502	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
365044011503	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
365044011504	cell density-dependent motility repressor; Provisional; Region: PRK10082
365044011505	Helix-turn-helix domains; Region: HTH; cl00088
365044011506	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044011507	dimerization interface [polypeptide binding]; other site
365044011508	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
365044011509	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
365044011510	inhibitor site; inhibition site
365044011511	active site
365044011512	dimer interface [polypeptide binding]; other site
365044011513	catalytic residue [active]
365044011514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044011515	NMT1-like family; Region: NMT1_2; cl15260
365044011516	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
365044011517	classical (c) SDRs; Region: SDR_c; cd05233
365044011518	NAD(P) binding site [chemical binding]; other site
365044011519	active site
365044011520	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
365044011521	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
365044011522	putative active site pocket [active]
365044011523	metal binding site [ion binding]; metal-binding site
365044011524	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044011525	nudix motif; other site
365044011526	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
365044011527	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
365044011528	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044011529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044011530	substrate binding pocket [chemical binding]; other site
365044011531	membrane-bound complex binding site; other site
365044011532	hinge residues; other site
365044011533	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
365044011534	Helix-turn-helix domains; Region: HTH; cl00088
365044011535	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
365044011536	putative dimerization interface [polypeptide binding]; other site
365044011537	Helix-turn-helix domains; Region: HTH; cl00088
365044011538	Rrf2 family protein; Region: rrf2_super; TIGR00738
365044011539	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
365044011540	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
365044011541	dimer interface [polypeptide binding]; other site
365044011542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044011543	catalytic residue [active]
365044011544	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
365044011545	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
365044011546	Peptidase family M48; Region: Peptidase_M48; cl12018
365044011547	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
365044011548	LabA_like proteins; Region: LabA_like/DUF88; cl10034
365044011549	putative metal binding site [ion binding]; other site
365044011550	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
365044011551	active site
365044011552	substrate binding pocket [chemical binding]; other site
365044011553	dimer interface [polypeptide binding]; other site
365044011554	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
365044011555	DctM-like transporters; Region: DctM; pfam06808
365044011556	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
365044011557	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044011558	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044011559	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044011560	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
365044011561	Walker A/P-loop; other site
365044011562	ATP binding site [chemical binding]; other site
365044011563	Q-loop/lid; other site
365044011564	ABC transporter signature motif; other site
365044011565	Walker B; other site
365044011566	D-loop; other site
365044011567	H-loop/switch region; other site
365044011568	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
365044011569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011570	dimer interface [polypeptide binding]; other site
365044011571	conserved gate region; other site
365044011572	putative PBP binding loops; other site
365044011573	ABC-ATPase subunit interface; other site
365044011574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011575	dimer interface [polypeptide binding]; other site
365044011576	conserved gate region; other site
365044011577	putative PBP binding loops; other site
365044011578	ABC-ATPase subunit interface; other site
365044011579	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
365044011580	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044011581	substrate binding pocket [chemical binding]; other site
365044011582	membrane-bound complex binding site; other site
365044011583	hinge residues; other site
365044011584	Helix-turn-helix domains; Region: HTH; cl00088
365044011585	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
365044011586	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044011587	dimerization interface [polypeptide binding]; other site
365044011588	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
365044011589	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
365044011590	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044011591	Walker A/P-loop; other site
365044011592	ATP binding site [chemical binding]; other site
365044011593	Q-loop/lid; other site
365044011594	ABC transporter signature motif; other site
365044011595	Walker B; other site
365044011596	D-loop; other site
365044011597	H-loop/switch region; other site
365044011598	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
365044011599	DNA binding residues [nucleotide binding]
365044011600	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044011601	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
365044011602	MgtC family; Region: MgtC; pfam02308
365044011603	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
365044011604	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
365044011605	putative NAD(P) binding site [chemical binding]; other site
365044011606	active site
365044011607	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044011608	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
365044011609	putative C-terminal domain interface [polypeptide binding]; other site
365044011610	putative GSH binding site (G-site) [chemical binding]; other site
365044011611	putative dimer interface [polypeptide binding]; other site
365044011612	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
365044011613	putative N-terminal domain interface [polypeptide binding]; other site
365044011614	putative dimer interface [polypeptide binding]; other site
365044011615	putative substrate binding pocket (H-site) [chemical binding]; other site
365044011616	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
365044011617	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
365044011618	active site
365044011619	NTP binding site [chemical binding]; other site
365044011620	metal binding triad [ion binding]; metal-binding site
365044011621	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
365044011622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
365044011623	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044011624	CoenzymeA binding site [chemical binding]; other site
365044011625	subunit interaction site [polypeptide binding]; other site
365044011626	PHB binding site; other site
365044011627	Phasin protein; Region: Phasin_2; cl11491
365044011628	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
365044011629	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
365044011630	putative active site [active]
365044011631	catalytic site [active]
365044011632	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
365044011633	putative active site [active]
365044011634	catalytic site [active]
365044011635	L-lactate permease; Region: Lactate_perm; cl00701
365044011636	glycolate transporter; Provisional; Region: PRK09695
365044011637	enoyl-CoA hydratase; Provisional; Region: PRK06688
365044011638	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044011639	substrate binding site [chemical binding]; other site
365044011640	oxyanion hole (OAH) forming residues; other site
365044011641	trimer interface [polypeptide binding]; other site
365044011642	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
365044011643	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
365044011644	dimer interface [polypeptide binding]; other site
365044011645	active site
365044011646	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
365044011647	CoenzymeA binding site [chemical binding]; other site
365044011648	subunit interaction site [polypeptide binding]; other site
365044011649	PHB binding site; other site
365044011650	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
365044011651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044011652	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
365044011653	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044011654	substrate binding site [chemical binding]; other site
365044011655	oxyanion hole (OAH) forming residues; other site
365044011656	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
365044011657	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
365044011658	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044011659	active site
365044011660	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
365044011661	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044011662	Helix-turn-helix domains; Region: HTH; cl00088
365044011663	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
365044011664	feedback inhibition sensing region; other site
365044011665	homohexameric interface [polypeptide binding]; other site
365044011666	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
365044011667	nucleotide binding site [chemical binding]; other site
365044011668	N-acetyl-L-glutamate binding site [chemical binding]; other site
365044011669	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
365044011670	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
365044011671	NAD(P) binding site [chemical binding]; other site
365044011672	homodimer interface [polypeptide binding]; other site
365044011673	substrate binding site [chemical binding]; other site
365044011674	active site
365044011675	Bacterial sugar transferase; Region: Bac_transf; cl00939
365044011676	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044011677	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
365044011678	putative NAD(P) binding site [chemical binding]; other site
365044011679	active site
365044011680	putative substrate binding site [chemical binding]; other site
365044011681	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
365044011682	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
365044011683	putative ADP-binding pocket [chemical binding]; other site
365044011684	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
365044011685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044011686	NAD(P) binding site [chemical binding]; other site
365044011687	active site
365044011688	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
365044011689	Probable Catalytic site; other site
365044011690	O-Antigen ligase; Region: Wzy_C; cl04850
365044011691	MatE; Region: MatE; cl10513
365044011692	MatE; Region: MatE; cl10513
365044011693	Cupin domain; Region: Cupin_2; cl09118
365044011694	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
365044011695	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
365044011696	substrate binding site; other site
365044011697	tetramer interface; other site
365044011698	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
365044011699	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
365044011700	NADP binding site [chemical binding]; other site
365044011701	active site
365044011702	putative substrate binding site [chemical binding]; other site
365044011703	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
365044011704	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
365044011705	NAD binding site [chemical binding]; other site
365044011706	substrate binding site [chemical binding]; other site
365044011707	homodimer interface [polypeptide binding]; other site
365044011708	active site
365044011709	Chain length determinant protein; Region: Wzz; cl15801
365044011710	H-NS histone family; Region: Histone_HNS; pfam00816
365044011711	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
365044011712	short chain dehydrogenase; Provisional; Region: PRK07201
365044011713	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
365044011714	putative NAD(P) binding site [chemical binding]; other site
365044011715	active site
365044011716	putative substrate binding site [chemical binding]; other site
365044011717	classical (c) SDRs; Region: SDR_c; cd05233
365044011718	NAD(P) binding site [chemical binding]; other site
365044011719	active site
365044011720	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
365044011721	Helix-turn-helix domains; Region: HTH; cl00088
365044011722	Bacterial transcriptional repressor; Region: TetR; pfam13972
365044011723	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
365044011724	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
365044011725	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
365044011726	UbiA prenyltransferase family; Region: UbiA; cl00337
365044011727	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
365044011728	PAS domain S-box; Region: sensory_box; TIGR00229
365044011729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044011730	putative active site [active]
365044011731	heme pocket [chemical binding]; other site
365044011732	PAS domain S-box; Region: sensory_box; TIGR00229
365044011733	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044011734	GAF domain; Region: GAF_2; pfam13185
365044011735	GAF domain; Region: GAF; cl15785
365044011736	PAS domain S-box; Region: sensory_box; TIGR00229
365044011737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044011738	putative active site [active]
365044011739	heme pocket [chemical binding]; other site
365044011740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044011741	dimer interface [polypeptide binding]; other site
365044011742	phosphorylation site [posttranslational modification]
365044011743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011744	ATP binding site [chemical binding]; other site
365044011745	Mg2+ binding site [ion binding]; other site
365044011746	G-X-G motif; other site
365044011747	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
365044011748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044011749	Helix-turn-helix domains; Region: HTH; cl00088
365044011750	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044011751	dimerization interface [polypeptide binding]; other site
365044011752	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044011753	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044011754	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044011755	active site
365044011756	catalytic residues [active]
365044011757	metal binding site [ion binding]; metal-binding site
365044011758	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
365044011759	dimer interface [polypeptide binding]; other site
365044011760	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044011761	metal binding site [ion binding]; metal-binding site
365044011762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044011763	NMT1-like family; Region: NMT1_2; cl15260
365044011764	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
365044011765	acyl-CoA binding pocket [chemical binding]; other site
365044011766	CoA binding site [chemical binding]; other site
365044011767	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
365044011768	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
365044011769	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
365044011770	Type III pantothenate kinase; Region: Pan_kinase; cl09130
365044011771	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044011772	DNA binding residues [nucleotide binding]
365044011773	dimerization interface [polypeptide binding]; other site
365044011774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
365044011775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011776	ATP binding site [chemical binding]; other site
365044011777	Mg2+ binding site [ion binding]; other site
365044011778	G-X-G motif; other site
365044011779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
365044011780	active site
365044011781	phosphorylation site [posttranslational modification]
365044011782	intermolecular recognition site; other site
365044011783	dimerization interface [polypeptide binding]; other site
365044011784	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
365044011785	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044011786	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044011787	catalytic residue [active]
365044011788	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
365044011789	active site residue [active]
365044011790	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
365044011791	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044011792	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044011793	Walker A/P-loop; other site
365044011794	ATP binding site [chemical binding]; other site
365044011795	Q-loop/lid; other site
365044011796	ABC transporter signature motif; other site
365044011797	Walker B; other site
365044011798	D-loop; other site
365044011799	H-loop/switch region; other site
365044011800	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044011801	TM-ABC transporter signature motif; other site
365044011802	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044011803	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044011804	Walker A/P-loop; other site
365044011805	ATP binding site [chemical binding]; other site
365044011806	Q-loop/lid; other site
365044011807	ABC transporter signature motif; other site
365044011808	Walker B; other site
365044011809	D-loop; other site
365044011810	H-loop/switch region; other site
365044011811	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044011812	TM-ABC transporter signature motif; other site
365044011813	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044011814	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
365044011815	putative ligand binding site [chemical binding]; other site
365044011816	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
365044011817	Cache domain; Region: Cache_2; cl07034
365044011818	Histidine kinase; Region: HisKA_3; pfam07730
365044011819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044011820	ATP binding site [chemical binding]; other site
365044011821	Mg2+ binding site [ion binding]; other site
365044011822	G-X-G motif; other site
365044011823	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044011824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044011825	active site
365044011826	phosphorylation site [posttranslational modification]
365044011827	intermolecular recognition site; other site
365044011828	dimerization interface [polypeptide binding]; other site
365044011829	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044011830	DNA binding residues [nucleotide binding]
365044011831	dimerization interface [polypeptide binding]; other site
365044011832	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
365044011833	B12 binding site [chemical binding]; other site
365044011834	cobalt ligand [ion binding]; other site
365044011835	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
365044011836	Walker A; other site
365044011837	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
365044011838	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
365044011839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044011840	NMT1-like family; Region: NMT1_2; cl15260
365044011841	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044011842	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044011843	Walker A/P-loop; other site
365044011844	ATP binding site [chemical binding]; other site
365044011845	Q-loop/lid; other site
365044011846	ABC transporter signature motif; other site
365044011847	Walker B; other site
365044011848	D-loop; other site
365044011849	H-loop/switch region; other site
365044011850	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044011851	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044011852	Walker A/P-loop; other site
365044011853	ATP binding site [chemical binding]; other site
365044011854	Q-loop/lid; other site
365044011855	ABC transporter signature motif; other site
365044011856	Walker B; other site
365044011857	D-loop; other site
365044011858	H-loop/switch region; other site
365044011859	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044011860	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
365044011861	putative ligand binding site [chemical binding]; other site
365044011862	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044011863	TM-ABC transporter signature motif; other site
365044011864	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044011865	TM-ABC transporter signature motif; other site
365044011866	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044011867	trimer interface [polypeptide binding]; other site
365044011868	eyelet of channel; other site
365044011869	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044011870	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
365044011871	Walker A/P-loop; other site
365044011872	ATP binding site [chemical binding]; other site
365044011873	Q-loop/lid; other site
365044011874	ABC transporter signature motif; other site
365044011875	Walker B; other site
365044011876	D-loop; other site
365044011877	H-loop/switch region; other site
365044011878	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044011879	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
365044011880	Walker A/P-loop; other site
365044011881	ATP binding site [chemical binding]; other site
365044011882	Q-loop/lid; other site
365044011883	ABC transporter signature motif; other site
365044011884	Walker B; other site
365044011885	D-loop; other site
365044011886	H-loop/switch region; other site
365044011887	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
365044011888	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
365044011889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011890	dimer interface [polypeptide binding]; other site
365044011891	conserved gate region; other site
365044011892	ABC-ATPase subunit interface; other site
365044011893	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
365044011894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044011895	dimer interface [polypeptide binding]; other site
365044011896	conserved gate region; other site
365044011897	putative PBP binding loops; other site
365044011898	ABC-ATPase subunit interface; other site
365044011899	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
365044011900	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
365044011901	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
365044011902	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
365044011903	putative active site pocket [active]
365044011904	metal binding site [ion binding]; metal-binding site
365044011905	Transcriptional regulators [Transcription]; Region: FadR; COG2186
365044011906	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044011907	DNA-binding site [nucleotide binding]; DNA binding site
365044011908	FCD domain; Region: FCD; cl11656
365044011909	RloB-like protein; Region: RloB; pfam13707
365044011910	Predicted ATPases [General function prediction only]; Region: COG1106
365044011911	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
365044011912	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
365044011913	ATP binding site [chemical binding]; other site
365044011914	Mg++ binding site [ion binding]; other site
365044011915	motif III; other site
365044011916	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
365044011917	nucleotide binding region [chemical binding]; other site
365044011918	ATP-binding site [chemical binding]; other site
365044011919	DbpA RNA binding domain; Region: DbpA; pfam03880
365044011920	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
365044011921	active site
365044011922	glutathione reductase; Validated; Region: PRK06116
365044011923	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
365044011924	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
365044011925	AMP nucleosidase; Provisional; Region: PRK08292
365044011926	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
365044011927	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
365044011928	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044011929	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044011930	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044011931	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044011932	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
365044011933	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
365044011934	Walker A/P-loop; other site
365044011935	ATP binding site [chemical binding]; other site
365044011936	Q-loop/lid; other site
365044011937	ABC transporter signature motif; other site
365044011938	Walker B; other site
365044011939	D-loop; other site
365044011940	H-loop/switch region; other site
365044011941	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
365044011942	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
365044011943	FtsX-like permease family; Region: FtsX; cl15850
365044011944	Haemolysin-III related; Region: HlyIII; cl03831
365044011945	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044011946	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
365044011947	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044011948	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
365044011949	active site
365044011950	ADP/pyrophosphate binding site [chemical binding]; other site
365044011951	dimerization interface [polypeptide binding]; other site
365044011952	allosteric effector site; other site
365044011953	fructose-1,6-bisphosphate binding site; other site
365044011954	Fic family protein [Function unknown]; Region: COG3177
365044011955	Fic/DOC family; Region: Fic; cl00960
365044011956	NMT1-like family; Region: NMT1_2; cl15260
365044011957	Double zinc ribbon; Region: DZR; pfam12773
365044011958	Transcriptional regulator; Region: Transcrip_reg; cl00361
365044011959	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
365044011960	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
365044011961	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
365044011962	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044011963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044011964	motif II; other site
365044011965	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
365044011966	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
365044011967	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
365044011968	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
365044011969	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
365044011970	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
365044011971	NAD binding site [chemical binding]; other site
365044011972	homotetramer interface [polypeptide binding]; other site
365044011973	homodimer interface [polypeptide binding]; other site
365044011974	substrate binding site [chemical binding]; other site
365044011975	active site
365044011976	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
365044011977	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
365044011978	dimer interaction site [polypeptide binding]; other site
365044011979	substrate-binding tunnel; other site
365044011980	active site
365044011981	catalytic site [active]
365044011982	substrate binding site [chemical binding]; other site
365044011983	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
365044011984	acetate kinase; Region: ackA; TIGR00016
365044011985	Acetokinase family; Region: Acetate_kinase; cl01029
365044011986	Mechanosensitive ion channel; Region: MS_channel; pfam00924
365044011987	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
365044011988	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
365044011989	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044011990	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
365044011991	nodulation ABC transporter NodI; Provisional; Region: PRK13537
365044011992	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
365044011993	Walker A/P-loop; other site
365044011994	ATP binding site [chemical binding]; other site
365044011995	Q-loop/lid; other site
365044011996	ABC transporter signature motif; other site
365044011997	Walker B; other site
365044011998	D-loop; other site
365044011999	H-loop/switch region; other site
365044012000	ABC-2 type transporter; Region: ABC2_membrane; cl11417
365044012001	CheB methylesterase; Region: CheB_methylest; pfam01339
365044012002	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012003	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
365044012004	putative ligand binding site [chemical binding]; other site
365044012005	YceI-like domain; Region: YceI; cl01001
365044012006	YceI-like domain; Region: YceI; cl01001
365044012007	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044012008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044012009	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365044012010	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044012011	Phosphotransferase enzyme family; Region: APH; pfam01636
365044012012	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
365044012013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
365044012014	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
365044012015	Peptidase family M23; Region: Peptidase_M23; pfam01551
365044012016	Peptidase M15; Region: Peptidase_M15_3; cl01194
365044012017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
365044012018	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
365044012019	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
365044012020	heat shock protein 90; Provisional; Region: PRK05218
365044012021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012022	ATP binding site [chemical binding]; other site
365044012023	Mg2+ binding site [ion binding]; other site
365044012024	G-X-G motif; other site
365044012025	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
365044012026	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044012027	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
365044012028	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
365044012029	RNA binding surface [nucleotide binding]; other site
365044012030	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
365044012031	active site
365044012032	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
365044012033	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044012034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012035	active site
365044012036	phosphorylation site [posttranslational modification]
365044012037	intermolecular recognition site; other site
365044012038	dimerization interface [polypeptide binding]; other site
365044012039	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012040	DNA binding residues [nucleotide binding]
365044012041	dimerization interface [polypeptide binding]; other site
365044012042	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044012043	Histidine kinase; Region: HisKA_3; pfam07730
365044012044	sensor protein RstB; Provisional; Region: PRK10604
365044012045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044012046	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
365044012047	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
365044012048	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044012049	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
365044012050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012051	active site
365044012052	phosphorylation site [posttranslational modification]
365044012053	intermolecular recognition site; other site
365044012054	dimerization interface [polypeptide binding]; other site
365044012055	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044012056	DNA binding site [nucleotide binding]
365044012057	sensor protein KdpD; Provisional; Region: PRK10490
365044012058	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
365044012059	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
365044012060	Ligand Binding Site [chemical binding]; other site
365044012061	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
365044012062	GAF domain; Region: GAF; cl15785
365044012063	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012064	dimer interface [polypeptide binding]; other site
365044012065	phosphorylation site [posttranslational modification]
365044012066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012067	ATP binding site [chemical binding]; other site
365044012068	Mg2+ binding site [ion binding]; other site
365044012069	G-X-G motif; other site
365044012070	K+-transporting ATPase, c chain; Region: KdpC; cl00944
365044012071	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
365044012072	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044012073	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
365044012074	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012075	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044012076	ligand binding site [chemical binding]; other site
365044012077	flexible hinge region; other site
365044012078	Helix-turn-helix domains; Region: HTH; cl00088
365044012079	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012080	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
365044012081	putative ligand binding site [chemical binding]; other site
365044012082	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
365044012083	AMP-binding enzyme; Region: AMP-binding; cl15778
365044012084	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
365044012085	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
365044012086	Walker A/P-loop; other site
365044012087	ATP binding site [chemical binding]; other site
365044012088	Q-loop/lid; other site
365044012089	ABC transporter signature motif; other site
365044012090	Walker B; other site
365044012091	D-loop; other site
365044012092	H-loop/switch region; other site
365044012093	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
365044012094	TM-ABC transporter signature motif; other site
365044012095	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
365044012096	TM-ABC transporter signature motif; other site
365044012097	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
365044012098	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012099	putative ligand binding site [chemical binding]; other site
365044012100	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
365044012101	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
365044012102	Walker A/P-loop; other site
365044012103	ATP binding site [chemical binding]; other site
365044012104	Q-loop/lid; other site
365044012105	ABC transporter signature motif; other site
365044012106	Walker B; other site
365044012107	D-loop; other site
365044012108	H-loop/switch region; other site
365044012109	AMP-binding enzyme; Region: AMP-binding; cl15778
365044012110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044012111	NMT1-like family; Region: NMT1_2; cl15260
365044012112	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
365044012113	Biofilm formation and stress response factor; Region: BsmA; cl01794
365044012114	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
365044012115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044012116	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
365044012117	active site
365044012118	FMN binding site [chemical binding]; other site
365044012119	substrate binding site [chemical binding]; other site
365044012120	homotetramer interface [polypeptide binding]; other site
365044012121	catalytic residue [active]
365044012122	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
365044012123	Helix-turn-helix domains; Region: HTH; cl00088
365044012124	enoyl-CoA hydratase; Provisional; Region: PRK06688
365044012125	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
365044012126	substrate binding site [chemical binding]; other site
365044012127	oxyanion hole (OAH) forming residues; other site
365044012128	trimer interface [polypeptide binding]; other site
365044012129	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
365044012130	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
365044012131	active site
365044012132	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
365044012133	AMP-binding enzyme; Region: AMP-binding; cl15778
365044012134	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044012135	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044012136	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
365044012137	active site
365044012138	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
365044012139	homotrimer interaction site [polypeptide binding]; other site
365044012140	putative active site [active]
365044012141	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012142	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044012143	ligand binding site [chemical binding]; other site
365044012144	flexible hinge region; other site
365044012145	Helix-turn-helix domains; Region: HTH; cl00088
365044012146	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012147	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
365044012148	Helix-turn-helix domains; Region: HTH; cl00088
365044012149	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044012150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012151	active site
365044012152	phosphorylation site [posttranslational modification]
365044012153	intermolecular recognition site; other site
365044012154	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012155	DNA binding residues [nucleotide binding]
365044012156	dimerization interface [polypeptide binding]; other site
365044012157	Response regulator receiver domain; Region: Response_reg; pfam00072
365044012158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012159	active site
365044012160	phosphorylation site [posttranslational modification]
365044012161	intermolecular recognition site; other site
365044012162	dimerization interface [polypeptide binding]; other site
365044012163	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
365044012164	Helix-turn-helix domains; Region: HTH; cl00088
365044012165	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
365044012166	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044012167	dimerization interface [polypeptide binding]; other site
365044012168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044012169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012170	dimer interface [polypeptide binding]; other site
365044012171	phosphorylation site [posttranslational modification]
365044012172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012173	ATP binding site [chemical binding]; other site
365044012174	Mg2+ binding site [ion binding]; other site
365044012175	G-X-G motif; other site
365044012176	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
365044012177	16S rRNA methyltransferase B; Provisional; Region: PRK10901
365044012178	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
365044012179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012180	S-adenosylmethionine binding site [chemical binding]; other site
365044012181	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044012182	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044012183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044012184	Integrase core domain; Region: rve; cl01316
365044012185	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044012186	Peptidase family M48; Region: Peptidase_M48; cl12018
365044012187	LemA family; Region: LemA; cl00742
365044012188	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
365044012189	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
365044012190	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
365044012191	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
365044012192	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
365044012193	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
365044012194	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
365044012195	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
365044012196	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
365044012197	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
365044012198	DNA binding site [nucleotide binding]
365044012199	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
365044012200	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
365044012201	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
365044012202	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
365044012203	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
365044012204	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
365044012205	RPB11 interaction site [polypeptide binding]; other site
365044012206	RPB12 interaction site [polypeptide binding]; other site
365044012207	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
365044012208	RPB3 interaction site [polypeptide binding]; other site
365044012209	RPB1 interaction site [polypeptide binding]; other site
365044012210	RPB11 interaction site [polypeptide binding]; other site
365044012211	RPB10 interaction site [polypeptide binding]; other site
365044012212	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
365044012213	peripheral dimer interface [polypeptide binding]; other site
365044012214	core dimer interface [polypeptide binding]; other site
365044012215	L10 interface [polypeptide binding]; other site
365044012216	L11 interface [polypeptide binding]; other site
365044012217	putative EF-Tu interaction site [polypeptide binding]; other site
365044012218	putative EF-G interaction site [polypeptide binding]; other site
365044012219	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
365044012220	23S rRNA interface [nucleotide binding]; other site
365044012221	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
365044012222	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
365044012223	mRNA/rRNA interface [nucleotide binding]; other site
365044012224	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
365044012225	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
365044012226	23S rRNA interface [nucleotide binding]; other site
365044012227	L7/L12 interface [polypeptide binding]; other site
365044012228	putative thiostrepton binding site; other site
365044012229	L25 interface [polypeptide binding]; other site
365044012230	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
365044012231	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
365044012232	putative homodimer interface [polypeptide binding]; other site
365044012233	KOW motif; Region: KOW; cl00354
365044012234	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
365044012235	elongation factor Tu; Reviewed; Region: PRK00049
365044012236	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
365044012237	G1 box; other site
365044012238	GEF interaction site [polypeptide binding]; other site
365044012239	GTP/Mg2+ binding site [chemical binding]; other site
365044012240	Switch I region; other site
365044012241	G2 box; other site
365044012242	G3 box; other site
365044012243	Switch II region; other site
365044012244	G4 box; other site
365044012245	G5 box; other site
365044012246	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
365044012247	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
365044012248	Antibiotic Binding Site [chemical binding]; other site
365044012249	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
365044012250	ligand binding site [chemical binding]; other site
365044012251	active site
365044012252	UGI interface [polypeptide binding]; other site
365044012253	catalytic site [active]
365044012254	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
365044012255	active site
365044012256	ribulose/triose binding site [chemical binding]; other site
365044012257	phosphate binding site [ion binding]; other site
365044012258	substrate (anthranilate) binding pocket [chemical binding]; other site
365044012259	product (indole) binding pocket [chemical binding]; other site
365044012260	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
365044012261	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
365044012262	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
365044012263	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044012264	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
365044012265	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044012266	catalytic residue [active]
365044012267	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
365044012268	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
365044012269	glutamine binding [chemical binding]; other site
365044012270	catalytic triad [active]
365044012271	Chorismate mutase type II; Region: CM_2; cl00693
365044012272	anthranilate synthase component I; Provisional; Region: PRK13565
365044012273	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
365044012274	chorismate binding enzyme; Region: Chorismate_bind; cl10555
365044012275	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
365044012276	phosphoglycolate phosphatase; Provisional; Region: PRK13222
365044012277	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044012278	motif II; other site
365044012279	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044012280	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
365044012281	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
365044012282	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
365044012283	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
365044012284	substrate binding site [chemical binding]; other site
365044012285	hexamer interface [polypeptide binding]; other site
365044012286	metal binding site [ion binding]; metal-binding site
365044012287	Protein of unknown function (DUF525); Region: DUF525; cl01119
365044012288	Site-specific recombinase; Region: SpecificRecomb; cl15411
365044012289	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
365044012290	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
365044012291	thiamine monophosphate kinase; Provisional; Region: PRK05731
365044012292	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
365044012293	ATP binding site [chemical binding]; other site
365044012294	dimerization interface [polypeptide binding]; other site
365044012295	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
365044012296	tetramer interfaces [polypeptide binding]; other site
365044012297	binuclear metal-binding site [ion binding]; other site
365044012298	Competence-damaged protein; Region: CinA; cl00666
365044012299	OsmC-like protein; Region: OsmC; cl00767
365044012300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044012301	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
365044012302	Helix-turn-helix domains; Region: HTH; cl00088
365044012303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012304	S-adenosylmethionine binding site [chemical binding]; other site
365044012305	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
365044012306	DNA-K related protein; Region: DUF3731; pfam12531
365044012307	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
365044012308	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
365044012309	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
365044012310	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
365044012311	ligand binding site [chemical binding]; other site
365044012312	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
365044012313	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
365044012314	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
365044012315	oligomeric interface; other site
365044012316	putative active site [active]
365044012317	homodimer interface [polypeptide binding]; other site
365044012318	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
365044012319	active site
365044012320	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
365044012321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044012322	motif II; other site
365044012323	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
365044012324	active site
365044012325	catalytic residues [active]
365044012326	metal binding site [ion binding]; metal-binding site
365044012327	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044012328	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044012329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012330	active site
365044012331	phosphorylation site [posttranslational modification]
365044012332	intermolecular recognition site; other site
365044012333	dimerization interface [polypeptide binding]; other site
365044012334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044012335	DNA binding site [nucleotide binding]
365044012336	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
365044012337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012338	dimer interface [polypeptide binding]; other site
365044012339	phosphorylation site [posttranslational modification]
365044012340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012341	ATP binding site [chemical binding]; other site
365044012342	Mg2+ binding site [ion binding]; other site
365044012343	G-X-G motif; other site
365044012344	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
365044012345	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
365044012346	active site
365044012347	catalytic tetrad [active]
365044012348	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
365044012349	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044012350	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
365044012351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
365044012352	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
365044012353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012354	dimer interface [polypeptide binding]; other site
365044012355	conserved gate region; other site
365044012356	putative PBP binding loops; other site
365044012357	ABC-ATPase subunit interface; other site
365044012358	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
365044012359	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
365044012360	Walker A/P-loop; other site
365044012361	ATP binding site [chemical binding]; other site
365044012362	Q-loop/lid; other site
365044012363	ABC transporter signature motif; other site
365044012364	Walker B; other site
365044012365	D-loop; other site
365044012366	H-loop/switch region; other site
365044012367	TOBE domain; Region: TOBE_2; cl01440
365044012368	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
365044012369	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
365044012370	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
365044012371	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
365044012372	glucokinase, proteobacterial type; Region: glk; TIGR00749
365044012373	PQ loop repeat; Region: PQ-loop; cl12056
365044012374	LysR family transcriptional regulator; Provisional; Region: PRK14997
365044012375	Helix-turn-helix domains; Region: HTH; cl00088
365044012376	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044012377	putative effector binding pocket; other site
365044012378	dimerization interface [polypeptide binding]; other site
365044012379	LysE type translocator; Region: LysE; cl00565
365044012380	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
365044012381	Helix-turn-helix domains; Region: HTH; cl00088
365044012382	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044012383	dimerization interface [polypeptide binding]; other site
365044012384	psiF repeat; Region: PsiF_repeat; pfam07769
365044012385	psiF repeat; Region: PsiF_repeat; pfam07769
365044012386	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
365044012387	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
365044012388	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
365044012389	active site
365044012390	HIGH motif; other site
365044012391	KMSK motif region; other site
365044012392	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
365044012393	tRNA binding surface [nucleotide binding]; other site
365044012394	anticodon binding site; other site
365044012395	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
365044012396	Sporulation related domain; Region: SPOR; cl10051
365044012397	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
365044012398	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
365044012399	catalytic residues [active]
365044012400	hinge region; other site
365044012401	alpha helical domain; other site
365044012402	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
365044012403	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044012404	Surface antigen; Region: Bac_surface_Ag; cl03097
365044012405	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
365044012406	haemagglutination activity domain; Region: Haemagg_act; cl05436
365044012407	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
365044012408	active site
365044012409	Tetratricopeptide repeat; Region: TPR_12; pfam13424
365044012410	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
365044012411	binding surface
365044012412	TPR motif; other site
365044012413	OstA-like protein; Region: OstA; cl00844
365044012414	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
365044012415	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
365044012416	Walker A/P-loop; other site
365044012417	ATP binding site [chemical binding]; other site
365044012418	Q-loop/lid; other site
365044012419	ABC transporter signature motif; other site
365044012420	Walker B; other site
365044012421	D-loop; other site
365044012422	H-loop/switch region; other site
365044012423	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
365044012424	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
365044012425	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
365044012426	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
365044012427	THUMP domain; Region: THUMP; cl12076
365044012428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044012429	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
365044012430	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044012431	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
365044012432	putative active site [active]
365044012433	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
365044012434	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
365044012435	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044012436	active site
365044012437	nucleotide binding site [chemical binding]; other site
365044012438	HIGH motif; other site
365044012439	KMSKS motif; other site
365044012440	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044012441	nudix motif; other site
365044012442	NAD synthetase; Provisional; Region: PRK13981
365044012443	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
365044012444	multimer interface [polypeptide binding]; other site
365044012445	active site
365044012446	catalytic triad [active]
365044012447	protein interface 1 [polypeptide binding]; other site
365044012448	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
365044012449	homodimer interface [polypeptide binding]; other site
365044012450	NAD binding pocket [chemical binding]; other site
365044012451	ATP binding pocket [chemical binding]; other site
365044012452	Mg binding site [ion binding]; other site
365044012453	active-site loop [active]
365044012454	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
365044012455	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
365044012456	active site
365044012457	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
365044012458	catalytic triad [active]
365044012459	conserved cis-peptide bond; other site
365044012460	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
365044012461	nudix motif; other site
365044012462	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
365044012463	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
365044012464	Winged helix-turn helix; Region: HTH_29; pfam13551
365044012465	Winged helix-turn helix; Region: HTH_33; pfam13592
365044012466	Integrase core domain; Region: rve; cl01316
365044012467	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
365044012468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044012469	S-adenosylmethionine binding site [chemical binding]; other site
365044012470	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044012471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012472	dimer interface [polypeptide binding]; other site
365044012473	phosphorylation site [posttranslational modification]
365044012474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012475	ATP binding site [chemical binding]; other site
365044012476	G-X-G motif; other site
365044012477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012478	active site
365044012479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044012480	phosphorylation site [posttranslational modification]
365044012481	intermolecular recognition site; other site
365044012482	dimerization interface [polypeptide binding]; other site
365044012483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012484	dimer interface [polypeptide binding]; other site
365044012485	phosphorylation site [posttranslational modification]
365044012486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012487	ATP binding site [chemical binding]; other site
365044012488	G-X-G motif; other site
365044012489	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
365044012490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012491	active site
365044012492	phosphorylation site [posttranslational modification]
365044012493	intermolecular recognition site; other site
365044012494	dimerization interface [polypeptide binding]; other site
365044012495	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044012496	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044012497	DTAP/Switch II; other site
365044012498	Switch I; other site
365044012499	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
365044012500	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
365044012501	P loop; other site
365044012502	Nucleotide binding site [chemical binding]; other site
365044012503	DTAP/Switch II; other site
365044012504	Switch I; other site
365044012505	Restriction endonuclease; Region: Mrr_cat; cl00516
365044012506	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
365044012507	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
365044012508	active site 1 [active]
365044012509	dimer interface [polypeptide binding]; other site
365044012510	hexamer interface [polypeptide binding]; other site
365044012511	active site 2 [active]
365044012512	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
365044012513	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
365044012514	putative active site [active]
365044012515	putative dimer interface [polypeptide binding]; other site
365044012516	TM1410 hypothetical-related protein; Region: DUF297; cl00997
365044012517	glutathione synthetase; Provisional; Region: PRK05246
365044012518	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
365044012519	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044012520	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044012521	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
365044012522	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
365044012523	metal ion-dependent adhesion site (MIDAS); other site
365044012524	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
365044012525	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
365044012526	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
365044012527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012528	active site
365044012529	phosphorylation site [posttranslational modification]
365044012530	intermolecular recognition site; other site
365044012531	dimerization interface [polypeptide binding]; other site
365044012532	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012533	DNA binding residues [nucleotide binding]
365044012534	dimerization interface [polypeptide binding]; other site
365044012535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044012536	putative active site [active]
365044012537	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044012538	heme pocket [chemical binding]; other site
365044012539	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012540	dimer interface [polypeptide binding]; other site
365044012541	phosphorylation site [posttranslational modification]
365044012542	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012543	ATP binding site [chemical binding]; other site
365044012544	G-X-G motif; other site
365044012545	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044012546	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
365044012547	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
365044012548	K+ potassium transporter; Region: K_trans; cl15781
365044012549	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
365044012550	Glutamate-cysteine ligase; Region: GshA; pfam08886
365044012551	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
365044012552	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
365044012553	putative catalytic cysteine [active]
365044012554	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
365044012555	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
365044012556	putative FMN binding site [chemical binding]; other site
365044012557	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
365044012558	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
365044012559	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
365044012560	protein-splicing catalytic site; other site
365044012561	thioester formation/cholesterol transfer; other site
365044012562	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
365044012563	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
365044012564	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
365044012565	active site clefts [active]
365044012566	zinc binding site [ion binding]; other site
365044012567	dimer interface [polypeptide binding]; other site
365044012568	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998
365044012569	PPIC-type PPIASE domain; Region: Rotamase; cl08278
365044012570	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
365044012571	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
365044012572	nitrate reductase, beta subunit; Region: narH; TIGR01660
365044012573	4Fe-4S binding domain; Region: Fer4; cl02805
365044012574	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
365044012575	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
365044012576	[4Fe-4S] binding site [ion binding]; other site
365044012577	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044012578	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044012579	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
365044012580	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
365044012581	molybdopterin cofactor binding site; other site
365044012582	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
365044012583	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
365044012584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044012585	putative substrate translocation pore; other site
365044012586	transcriptional regulator NarL; Provisional; Region: PRK10651
365044012587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012588	active site
365044012589	phosphorylation site [posttranslational modification]
365044012590	intermolecular recognition site; other site
365044012591	dimerization interface [polypeptide binding]; other site
365044012592	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012593	DNA binding residues [nucleotide binding]
365044012594	dimerization interface [polypeptide binding]; other site
365044012595	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
365044012596	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
365044012597	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
365044012598	dimerization interface [polypeptide binding]; other site
365044012599	GAF domain; Region: GAF; cl15785
365044012600	Histidine kinase; Region: HisKA_3; pfam07730
365044012601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012602	ATP binding site [chemical binding]; other site
365044012603	Mg2+ binding site [ion binding]; other site
365044012604	G-X-G motif; other site
365044012605	Mannitol repressor; Region: MtlR; cl11450
365044012606	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
365044012607	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
365044012608	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
365044012609	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044012610	Helix-turn-helix domains; Region: HTH; cl00088
365044012611	AsnC family; Region: AsnC_trans_reg; pfam01037
365044012612	ornithine cyclodeaminase; Validated; Region: PRK07589
365044012613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044012614	Arginase family; Region: Arginase; cl00306
365044012615	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
365044012616	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
365044012617	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044012618	FeS/SAM binding site; other site
365044012619	HemN C-terminal domain; Region: HemN_C; pfam06969
365044012620	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
365044012621	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044012622	ligand binding site [chemical binding]; other site
365044012623	flexible hinge region; other site
365044012624	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
365044012625	putative switch regulator; other site
365044012626	non-specific DNA interactions [nucleotide binding]; other site
365044012627	DNA binding site [nucleotide binding]
365044012628	sequence specific DNA binding site [nucleotide binding]; other site
365044012629	putative cAMP binding site [chemical binding]; other site
365044012630	FixH; Region: FixH; cl01254
365044012631	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
365044012632	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044012633	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
365044012634	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
365044012635	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
365044012636	Cytochrome c; Region: Cytochrom_C; cl11414
365044012637	Cytochrome c; Region: Cytochrom_C; cl11414
365044012638	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
365044012639	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
365044012640	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
365044012641	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
365044012642	Low-spin heme binding site [chemical binding]; other site
365044012643	Putative water exit pathway; other site
365044012644	Binuclear center (active site) [active]
365044012645	Putative proton exit pathway; other site
365044012646	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
365044012647	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044012648	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044012649	metal-binding site [ion binding]
365044012650	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044012651	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044012652	Lipopolysaccharide-assembly; Region: LptE; cl01125
365044012653	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
365044012654	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
365044012655	HIGH motif; other site
365044012656	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
365044012657	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044012658	active site
365044012659	KMSKS motif; other site
365044012660	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
365044012661	tRNA binding surface [nucleotide binding]; other site
365044012662	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
365044012663	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
365044012664	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
365044012665	dihydrodipicolinate reductase; Provisional; Region: PRK00048
365044012666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044012667	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
365044012668	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
365044012669	ferric uptake regulator; Provisional; Region: fur; PRK09462
365044012670	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
365044012671	metal binding site 2 [ion binding]; metal-binding site
365044012672	putative DNA binding helix; other site
365044012673	metal binding site 1 [ion binding]; metal-binding site
365044012674	dimer interface [polypeptide binding]; other site
365044012675	structural Zn2+ binding site [ion binding]; other site
365044012676	HPr kinase/phosphorylase; Provisional; Region: PRK05428
365044012677	DRTGG domain; Region: DRTGG; cl12147
365044012678	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
365044012679	Hpr binding site; other site
365044012680	active site
365044012681	homohexamer subunit interaction site [polypeptide binding]; other site
365044012682	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
365044012683	active site
365044012684	phosphorylation site [posttranslational modification]
365044012685	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
365044012686	30S subunit binding site; other site
365044012687	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
365044012688	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
365044012689	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
365044012690	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
365044012691	AMP-binding enzyme; Region: AMP-binding; cl15778
365044012692	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
365044012693	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
365044012694	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
365044012695	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
365044012696	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
365044012697	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
365044012698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044012699	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
365044012700	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044012701	tetrameric interface [polypeptide binding]; other site
365044012702	NAD binding site [chemical binding]; other site
365044012703	catalytic residues [active]
365044012704	Helix-turn-helix domains; Region: HTH; cl00088
365044012705	LysR family transcriptional regulator; Provisional; Region: PRK14997
365044012706	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044012707	putative effector binding pocket; other site
365044012708	dimerization interface [polypeptide binding]; other site
365044012709	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
365044012710	nudix motif; other site
365044012711	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
365044012712	PrpF protein; Region: PrpF; pfam04303
365044012713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044012714	NMT1-like family; Region: NMT1_2; cl15260
365044012715	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044012716	Helix-turn-helix domains; Region: HTH; cl00088
365044012717	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
365044012718	putative dimerization interface [polypeptide binding]; other site
365044012719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044012720	NMT1-like family; Region: NMT1_2; cl15260
365044012721	Uncharacterized conserved protein [Function unknown]; Region: COG3777
365044012722	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
365044012723	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
365044012724	active site 2 [active]
365044012725	active site 1 [active]
365044012726	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
365044012727	CoA-transferase family III; Region: CoA_transf_3; pfam02515
365044012728	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044012729	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
365044012730	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
365044012731	tetramer interface [polypeptide binding]; other site
365044012732	active site
365044012733	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
365044012734	trimer interface [polypeptide binding]; other site
365044012735	eyelet of channel; other site
365044012736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044012737	NMT1-like family; Region: NMT1_2; cl15260
365044012738	tricarballylate utilization protein B; Provisional; Region: PRK15033
365044012739	tricarballylate dehydrogenase; Validated; Region: PRK08274
365044012740	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
365044012741	Helix-turn-helix domains; Region: HTH; cl00088
365044012742	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
365044012743	putative dimerization interface [polypeptide binding]; other site
365044012744	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
365044012745	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
365044012746	Ligand Binding Site [chemical binding]; other site
365044012747	MltA-interacting protein MipA; Region: MipA; cl01504
365044012748	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
365044012749	dimer interface [polypeptide binding]; other site
365044012750	ssDNA binding site [nucleotide binding]; other site
365044012751	tetramer (dimer of dimers) interface [polypeptide binding]; other site
365044012752	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
365044012753	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
365044012754	putative ion selectivity filter; other site
365044012755	putative pore gating glutamate residue; other site
365044012756	putative H+/Cl- coupling transport residue; other site
365044012757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044012758	putative substrate translocation pore; other site
365044012759	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
365044012760	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
365044012761	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
365044012762	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
365044012763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012764	active site
365044012765	phosphorylation site [posttranslational modification]
365044012766	intermolecular recognition site; other site
365044012767	dimerization interface [polypeptide binding]; other site
365044012768	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044012769	DNA binding site [nucleotide binding]
365044012770	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
365044012771	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044012772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012773	dimer interface [polypeptide binding]; other site
365044012774	phosphorylation site [posttranslational modification]
365044012775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012776	ATP binding site [chemical binding]; other site
365044012777	Mg2+ binding site [ion binding]; other site
365044012778	G-X-G motif; other site
365044012779	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
365044012780	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044012781	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
365044012782	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
365044012783	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
365044012784	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
365044012785	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
365044012786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012787	dimer interface [polypeptide binding]; other site
365044012788	conserved gate region; other site
365044012789	putative PBP binding loops; other site
365044012790	ABC-ATPase subunit interface; other site
365044012791	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
365044012792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044012793	dimer interface [polypeptide binding]; other site
365044012794	conserved gate region; other site
365044012795	putative PBP binding loops; other site
365044012796	ABC-ATPase subunit interface; other site
365044012797	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044012798	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
365044012799	Walker A/P-loop; other site
365044012800	ATP binding site [chemical binding]; other site
365044012801	Q-loop/lid; other site
365044012802	ABC transporter signature motif; other site
365044012803	Walker B; other site
365044012804	D-loop; other site
365044012805	H-loop/switch region; other site
365044012806	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
365044012807	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
365044012808	Walker A/P-loop; other site
365044012809	ATP binding site [chemical binding]; other site
365044012810	Q-loop/lid; other site
365044012811	ABC transporter signature motif; other site
365044012812	Walker B; other site
365044012813	D-loop; other site
365044012814	H-loop/switch region; other site
365044012815	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
365044012816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
365044012817	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
365044012818	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
365044012819	NAD(P) binding site [chemical binding]; other site
365044012820	catalytic residues [active]
365044012821	Cytochrome c; Region: Cytochrom_C; cl11414
365044012822	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
365044012823	FAD binding domain; Region: FAD_binding_4; pfam01565
365044012824	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
365044012825	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
365044012826	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044012827	active site
365044012828	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
365044012829	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
365044012830	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
365044012831	active site
365044012832	dimer interface [polypeptide binding]; other site
365044012833	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
365044012834	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
365044012835	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
365044012836	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
365044012837	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
365044012838	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
365044012839	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044012840	N-formylglutamate amidohydrolase; Region: FGase; cl01522
365044012841	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
365044012842	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
365044012843	PhnA protein; Region: PhnA; pfam03831
365044012844	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
365044012845	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
365044012846	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
365044012847	tetramer interface [polypeptide binding]; other site
365044012848	catalytic Zn binding site [ion binding]; other site
365044012849	NADP binding site [chemical binding]; other site
365044012850	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
365044012851	Iron permease FTR1 family; Region: FTR1; cl00475
365044012852	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
365044012853	Sel1 repeat; Region: Sel1; cl02723
365044012854	Sel1 repeat; Region: Sel1; cl02723
365044012855	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044012856	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
365044012857	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
365044012858	SlyX; Region: SlyX; cl01090
365044012859	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
365044012860	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
365044012861	dimerization interface [polypeptide binding]; other site
365044012862	ligand binding site [chemical binding]; other site
365044012863	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
365044012864	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
365044012865	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
365044012866	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044012867	AIR carboxylase; Region: AIRC; cl00310
365044012868	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
365044012869	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044012870	Ribbon-helix-helix domain; Region: RHH_4; cl01775
365044012871	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
365044012872	conserved cys residue [active]
365044012873	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
365044012874	ATP binding site [chemical binding]; other site
365044012875	active site
365044012876	substrate binding site [chemical binding]; other site
365044012877	hypothetical protein; Provisional; Region: PRK08185
365044012878	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
365044012879	intersubunit interface [polypeptide binding]; other site
365044012880	active site
365044012881	zinc binding site [ion binding]; other site
365044012882	Na+ binding site [ion binding]; other site
365044012883	sensor protein QseC; Provisional; Region: PRK10337
365044012884	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
365044012885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
365044012886	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
365044012887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012888	active site
365044012889	phosphorylation site [posttranslational modification]
365044012890	intermolecular recognition site; other site
365044012891	dimerization interface [polypeptide binding]; other site
365044012892	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044012893	DNA binding site [nucleotide binding]
365044012894	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
365044012895	active site
365044012896	pyruvate kinase; Provisional; Region: PRK05826
365044012897	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
365044012898	domain interfaces; other site
365044012899	active site
365044012900	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198
365044012901	Phosphoglycerate kinase; Region: PGK; pfam00162
365044012902	substrate binding site [chemical binding]; other site
365044012903	hinge regions; other site
365044012904	ADP binding site [chemical binding]; other site
365044012905	catalytic site [active]
365044012906	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
365044012907	AzlC protein; Region: AzlC; cl00570
365044012908	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
365044012909	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
365044012910	putative active site [active]
365044012911	substrate binding site [chemical binding]; other site
365044012912	putative cosubstrate binding site; other site
365044012913	catalytic site [active]
365044012914	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
365044012915	substrate binding site [chemical binding]; other site
365044012916	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
365044012917	active site
365044012918	catalytic residues [active]
365044012919	metal binding site [ion binding]; metal-binding site
365044012920	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
365044012921	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
365044012922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044012923	Probable transposase; Region: OrfB_IS605; pfam01385
365044012924	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044012925	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
365044012926	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
365044012927	Protein of unknown function (DUF494); Region: DUF494; cl01103
365044012928	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
365044012929	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
365044012930	Protein export membrane protein; Region: SecD_SecF; cl14618
365044012931	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
365044012932	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
365044012933	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
365044012934	Protein export membrane protein; Region: SecD_SecF; cl14618
365044012935	Preprotein translocase subunit; Region: YajC; cl00806
365044012936	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
365044012937	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
365044012938	dimer interface [polypeptide binding]; other site
365044012939	PYR/PP interface [polypeptide binding]; other site
365044012940	TPP binding site [chemical binding]; other site
365044012941	substrate binding site [chemical binding]; other site
365044012942	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
365044012943	TPP-binding site; other site
365044012944	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
365044012945	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
365044012946	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
365044012947	putative DNA binding site [nucleotide binding]; other site
365044012948	putative Zn2+ binding site [ion binding]; other site
365044012949	AsnC family; Region: AsnC_trans_reg; pfam01037
365044012950	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
365044012951	MltA specific insert domain; Region: MltA; cl08398
365044012952	3D domain; Region: 3D; cl01439
365044012953	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
365044012954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044012955	active site
365044012956	phosphorylation site [posttranslational modification]
365044012957	intermolecular recognition site; other site
365044012958	dimerization interface [polypeptide binding]; other site
365044012959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044012960	DNA binding residues [nucleotide binding]
365044012961	dimerization interface [polypeptide binding]; other site
365044012962	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
365044012963	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
365044012964	putative active site [active]
365044012965	heme pocket [chemical binding]; other site
365044012966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044012967	dimer interface [polypeptide binding]; other site
365044012968	phosphorylation site [posttranslational modification]
365044012969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044012970	ATP binding site [chemical binding]; other site
365044012971	Mg2+ binding site [ion binding]; other site
365044012972	G-X-G motif; other site
365044012973	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044012974	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
365044012975	putative active site [active]
365044012976	catalytic triad [active]
365044012977	dimer interface [polypeptide binding]; other site
365044012978	TIGR02099 family protein; Region: TIGR02099
365044012979	AsmA-like C-terminal region; Region: AsmA_2; cl15864
365044012980	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044012981	metal binding triad; other site
365044012982	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
365044012983	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
365044012984	metal binding triad; other site
365044012985	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
365044012986	Helix-turn-helix domains; Region: HTH; cl00088
365044012987	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
365044012988	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
365044012989	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
365044012990	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044012991	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
365044012992	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
365044012993	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
365044012994	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
365044012995	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044012996	Helix-turn-helix domains; Region: HTH; cl00088
365044012997	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
365044012998	putative effector binding pocket; other site
365044012999	dimerization interface [polypeptide binding]; other site
365044013000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044013001	NMT1-like family; Region: NMT1_2; cl15260
365044013002	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
365044013003	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
365044013004	active site
365044013005	dimer interface [polypeptide binding]; other site
365044013006	metal binding site [ion binding]; metal-binding site
365044013007	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
365044013008	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
365044013009	NAD(P) binding site [chemical binding]; other site
365044013010	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
365044013011	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
365044013012	active site
365044013013	nucleotide binding site [chemical binding]; other site
365044013014	HIGH motif; other site
365044013015	KMSKS motif; other site
365044013016	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
365044013017	dinuclear metal binding motif [ion binding]; other site
365044013018	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
365044013019	catalytic residues [active]
365044013020	dimer interface [polypeptide binding]; other site
365044013021	putative glutathione S-transferase; Provisional; Region: PRK10357
365044013022	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
365044013023	putative C-terminal domain interface [polypeptide binding]; other site
365044013024	putative GSH binding site (G-site) [chemical binding]; other site
365044013025	putative dimer interface [polypeptide binding]; other site
365044013026	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
365044013027	dimer interface [polypeptide binding]; other site
365044013028	N-terminal domain interface [polypeptide binding]; other site
365044013029	putative substrate binding pocket (H-site) [chemical binding]; other site
365044013030	adenylosuccinate lyase; Provisional; Region: PRK09285
365044013031	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
365044013032	tetramer interface [polypeptide binding]; other site
365044013033	active site
365044013034	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
365044013035	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
365044013036	yybP-ykoY element as predicted by Rfam (RF00080), score 45.62
365044013037	Integral membrane protein TerC family; Region: TerC; cl10468
365044013038	Membrane protein of unknown function; Region: DUF360; cl00850
365044013039	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
365044013040	Peptidase family M48; Region: Peptidase_M48; cl12018
365044013041	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
365044013042	trimer interface [polypeptide binding]; other site
365044013043	dimer interface [polypeptide binding]; other site
365044013044	putative active site [active]
365044013045	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
365044013046	active site
365044013047	DNA binding site [nucleotide binding]
365044013048	Int/Topo IB signature motif; other site
365044013049	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
365044013050	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
365044013051	active site
365044013052	substrate binding site [chemical binding]; other site
365044013053	Mg2+ binding site [ion binding]; other site
365044013054	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044013055	putative active site [active]
365044013056	putative NTP binding site [chemical binding]; other site
365044013057	putative nucleic acid binding site [nucleotide binding]; other site
365044013058	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
365044013059	active site
365044013060	DNA binding site [nucleotide binding]
365044013061	catalytic site [active]
365044013062	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
365044013063	multiple promoter invertase; Provisional; Region: mpi; PRK13413
365044013064	catalytic residues [active]
365044013065	catalytic nucleophile [active]
365044013066	Presynaptic Site I dimer interface [polypeptide binding]; other site
365044013067	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
365044013068	Synaptic Flat tetramer interface [polypeptide binding]; other site
365044013069	Synaptic Site I dimer interface [polypeptide binding]; other site
365044013070	DNA binding site [nucleotide binding]
365044013071	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
365044013072	DNA-binding interface [nucleotide binding]; DNA binding site
365044013073	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
365044013074	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
365044013075	H-NS histone family; Region: Histone_HNS; pfam00816
365044013076	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
365044013077	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
365044013078	O-Antigen ligase; Region: Wzy_C; cl04850
365044013079	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
365044013080	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
365044013081	Pilin (bacterial filament); Region: Pilin; pfam00114
365044013082	putative major pilin subunit; Provisional; Region: PRK10574
365044013083	Pilin (bacterial filament); Region: Pilin; pfam00114
365044013084	putative major pilin subunit; Provisional; Region: PRK10574
365044013085	Pilin (bacterial filament); Region: Pilin; pfam00114
365044013086	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
365044013087	active site
365044013088	NTP binding site [chemical binding]; other site
365044013089	metal binding triad [ion binding]; metal-binding site
365044013090	antibiotic binding site [chemical binding]; other site
365044013091	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
365044013092	phosphopeptide binding site; other site
365044013093	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
365044013094	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
365044013095	active site
365044013096	Integral membrane protein TerC family; Region: TerC; cl10468
365044013097	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
365044013098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013099	CoA-ligase; Region: Ligase_CoA; cl02894
365044013100	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
365044013101	ATP-grasp domain; Region: ATP-grasp_4; cl03087
365044013102	CoA-ligase; Region: Ligase_CoA; cl02894
365044013103	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
365044013104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013105	RecX family; Region: RecX; cl00936
365044013106	recombinase A; Provisional; Region: recA; PRK09354
365044013107	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
365044013108	hexamer interface [polypeptide binding]; other site
365044013109	Walker A motif; other site
365044013110	ATP binding site [chemical binding]; other site
365044013111	Walker B motif; other site
365044013112	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
365044013113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013114	active site
365044013115	phosphorylation site [posttranslational modification]
365044013116	intermolecular recognition site; other site
365044013117	dimerization interface [polypeptide binding]; other site
365044013118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
365044013119	DNA binding site [nucleotide binding]
365044013120	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
365044013121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013122	dimer interface [polypeptide binding]; other site
365044013123	phosphorylation site [posttranslational modification]
365044013124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013125	ATP binding site [chemical binding]; other site
365044013126	Mg2+ binding site [ion binding]; other site
365044013127	G-X-G motif; other site
365044013128	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
365044013129	Peptidase C26; Region: Peptidase_C26; pfam07722
365044013130	catalytic triad [active]
365044013131	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
365044013132	FMN-binding domain; Region: FMN_bind; cl01081
365044013133	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
365044013134	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044013135	4Fe-4S binding domain; Region: Fer4_5; pfam12801
365044013136	ApbE family; Region: ApbE; cl00643
365044013137	DNA topoisomerase III; Provisional; Region: PRK14724
365044013138	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
365044013139	active site
365044013140	putative interdomain interaction site [polypeptide binding]; other site
365044013141	putative metal-binding site [ion binding]; other site
365044013142	putative nucleotide binding site [chemical binding]; other site
365044013143	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
365044013144	domain I; other site
365044013145	DNA binding groove [nucleotide binding]
365044013146	phosphate binding site [ion binding]; other site
365044013147	domain II; other site
365044013148	domain III; other site
365044013149	nucleotide binding site [chemical binding]; other site
365044013150	catalytic site [active]
365044013151	domain IV; other site
365044013152	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
365044013153	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
365044013154	SWIB/MDM2 domain; Region: SWIB; cl02489
365044013155	SET domain; Region: SET; cl02566
365044013156	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
365044013157	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
365044013158	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044013159	Predicted esterase [General function prediction only]; Region: COG0400
365044013160	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
365044013161	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
365044013162	NnrS protein; Region: NnrS; cl01258
365044013163	Restriction endonuclease; Region: Mrr_cat; cl00516
365044013164	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044013165	ATP binding site [chemical binding]; other site
365044013166	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
365044013167	putative Mg++ binding site [ion binding]; other site
365044013168	Family description; Region: UvrD_C_2; cl15862
365044013169	Methyltransferase domain; Region: Methyltransf_31; pfam13847
365044013170	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
365044013171	putative active site [active]
365044013172	putative NTP binding site [chemical binding]; other site
365044013173	putative nucleic acid binding site [nucleotide binding]; other site
365044013174	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
365044013175	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
365044013176	Fic family protein [Function unknown]; Region: COG3177
365044013177	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
365044013178	Fic/DOC family; Region: Fic; cl00960
365044013179	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
365044013180	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044013181	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
365044013182	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
365044013183	C-terminal domain interface [polypeptide binding]; other site
365044013184	GSH binding site (G-site) [chemical binding]; other site
365044013185	dimer interface [polypeptide binding]; other site
365044013186	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
365044013187	N-terminal domain interface [polypeptide binding]; other site
365044013188	dimer interface [polypeptide binding]; other site
365044013189	substrate binding pocket (H-site) [chemical binding]; other site
365044013190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044013191	S-adenosylmethionine binding site [chemical binding]; other site
365044013192	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
365044013193	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
365044013194	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
365044013195	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013196	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
365044013197	NAD(P) binding site [chemical binding]; other site
365044013198	active site
365044013199	short chain dehydrogenase; Provisional; Region: PRK12937
365044013200	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
365044013201	NADP binding site [chemical binding]; other site
365044013202	homodimer interface [polypeptide binding]; other site
365044013203	active site
365044013204	substrate binding site [chemical binding]; other site
365044013205	transcriptional regulator; Provisional; Region: PRK10632
365044013206	Helix-turn-helix domains; Region: HTH; cl00088
365044013207	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
365044013208	putative effector binding pocket; other site
365044013209	putative dimerization interface [polypeptide binding]; other site
365044013210	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
365044013211	dimer interface [polypeptide binding]; other site
365044013212	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
365044013213	Cupin domain; Region: Cupin_2; cl09118
365044013214	Pirin-related protein [General function prediction only]; Region: COG1741
365044013215	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
365044013216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013217	Response regulator receiver domain; Region: Response_reg; pfam00072
365044013218	active site
365044013219	phosphorylation site [posttranslational modification]
365044013220	intermolecular recognition site; other site
365044013221	dimerization interface [polypeptide binding]; other site
365044013222	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
365044013223	Helix-turn-helix domains; Region: HTH; cl00088
365044013224	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
365044013225	trimer interface [polypeptide binding]; other site
365044013226	active site
365044013227	dimer interface [polypeptide binding]; other site
365044013228	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
365044013229	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
365044013230	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
365044013231	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044013232	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044013233	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
365044013234	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
365044013235	DNA binding residues [nucleotide binding]
365044013236	dimer interface [polypeptide binding]; other site
365044013237	putative metal binding site [ion binding]; other site
365044013238	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
365044013239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
365044013240	putative substrate translocation pore; other site
365044013241	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013242	Helix-turn-helix domains; Region: HTH; cl00088
365044013243	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
365044013244	dimerization interface [polypeptide binding]; other site
365044013245	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
365044013246	cytosine deaminase; Validated; Region: PRK07572
365044013247	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
365044013248	active site
365044013249	Integrase core domain; Region: rve; cl01316
365044013250	Winged helix-turn helix; Region: HTH_29; pfam13551
365044013251	Helix-turn-helix domains; Region: HTH; cl00088
365044013252	Abortive infection C-terminus; Region: Abi_C; pfam14355
365044013253	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
365044013254	RNB domain; Region: RNB; pfam00773
365044013255	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
365044013256	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
365044013257	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
365044013258	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
365044013259	Surface antigen; Region: Bac_surface_Ag; cl03097
365044013260	haemagglutination activity domain; Region: Haemagg_act; cl05436
365044013261	FecR protein; Region: FecR; pfam04773
365044013262	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
365044013263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013264	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
365044013265	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
365044013266	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
365044013267	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
365044013268	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
365044013269	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
365044013270	homodimer interface [polypeptide binding]; other site
365044013271	active site
365044013272	FMN binding site [chemical binding]; other site
365044013273	substrate binding site [chemical binding]; other site
365044013274	4Fe-4S binding domain; Region: Fer4; cl02805
365044013275	4Fe-4S binding domain; Region: Fer4; cl02805
365044013276	phenylhydantoinase; Validated; Region: PRK08323
365044013277	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
365044013278	tetramer interface [polypeptide binding]; other site
365044013279	active site
365044013280	allantoate amidohydrolase; Reviewed; Region: PRK12893
365044013281	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
365044013282	active site
365044013283	metal binding site [ion binding]; metal-binding site
365044013284	dimer interface [polypeptide binding]; other site
365044013285	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
365044013286	heme-binding site [chemical binding]; other site
365044013287	Protein of unknown function DUF86; Region: DUF86; cl01031
365044013288	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
365044013289	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
365044013290	dimer interface [polypeptide binding]; other site
365044013291	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
365044013292	biotin synthase; Region: bioB; TIGR00433
365044013293	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
365044013294	FeS/SAM binding site; other site
365044013295	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
365044013296	AAA domain; Region: AAA_26; pfam13500
365044013297	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044013298	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044013299	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
365044013300	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
365044013301	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044013302	catalytic residue [active]
365044013303	Integrase core domain; Region: rve; cl01316
365044013304	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
365044013305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
365044013306	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
365044013307	Transcriptional regulator [Transcription]; Region: LysR; COG0583
365044013308	Helix-turn-helix domains; Region: HTH; cl00088
365044013309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
365044013310	dimerization interface [polypeptide binding]; other site
365044013311	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
365044013312	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
365044013313	inhibitor-cofactor binding pocket; inhibition site
365044013314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
365044013315	catalytic residue [active]
365044013316	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
365044013317	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044013318	ligand binding site [chemical binding]; other site
365044013319	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044013320	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
365044013321	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044013322	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
365044013323	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
365044013324	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
365044013325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013326	ATP binding site [chemical binding]; other site
365044013327	Mg2+ binding site [ion binding]; other site
365044013328	G-X-G motif; other site
365044013329	Uncharacterized conserved protein [Function unknown]; Region: COG3287
365044013330	FIST N domain; Region: FIST; cl10701
365044013331	FIST C domain; Region: FIST_C; pfam10442
365044013332	PAS fold; Region: PAS_4; pfam08448
365044013333	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
365044013334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013335	ATP binding site [chemical binding]; other site
365044013336	Mg2+ binding site [ion binding]; other site
365044013337	G-X-G motif; other site
365044013338	Response regulator receiver domain; Region: Response_reg; pfam00072
365044013339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013340	active site
365044013341	phosphorylation site [posttranslational modification]
365044013342	intermolecular recognition site; other site
365044013343	dimerization interface [polypeptide binding]; other site
365044013344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013345	dimer interface [polypeptide binding]; other site
365044013346	phosphorylation site [posttranslational modification]
365044013347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013348	ATP binding site [chemical binding]; other site
365044013349	Mg2+ binding site [ion binding]; other site
365044013350	G-X-G motif; other site
365044013351	Response regulator receiver domain; Region: Response_reg; pfam00072
365044013352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013353	active site
365044013354	phosphorylation site [posttranslational modification]
365044013355	intermolecular recognition site; other site
365044013356	dimerization interface [polypeptide binding]; other site
365044013357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013358	dimer interface [polypeptide binding]; other site
365044013359	phosphorylation site [posttranslational modification]
365044013360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013361	ATP binding site [chemical binding]; other site
365044013362	Mg2+ binding site [ion binding]; other site
365044013363	G-X-G motif; other site
365044013364	Response regulator receiver domain; Region: Response_reg; pfam00072
365044013365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013366	active site
365044013367	phosphorylation site [posttranslational modification]
365044013368	intermolecular recognition site; other site
365044013369	dimerization interface [polypeptide binding]; other site
365044013370	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
365044013371	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
365044013372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
365044013373	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
365044013374	dimer interface [polypeptide binding]; other site
365044013375	phosphorylation site [posttranslational modification]
365044013376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013377	ATP binding site [chemical binding]; other site
365044013378	Mg2+ binding site [ion binding]; other site
365044013379	G-X-G motif; other site
365044013380	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
365044013381	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
365044013382	putative ligand binding site [chemical binding]; other site
365044013383	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
365044013384	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044013385	Walker A/P-loop; other site
365044013386	ATP binding site [chemical binding]; other site
365044013387	Q-loop/lid; other site
365044013388	ABC transporter signature motif; other site
365044013389	Walker B; other site
365044013390	D-loop; other site
365044013391	H-loop/switch region; other site
365044013392	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
365044013393	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
365044013394	TM-ABC transporter signature motif; other site
365044013395	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
365044013396	TM-ABC transporter signature motif; other site
365044013397	Catalytic domain of Protein Kinases; Region: PKc; cd00180
365044013398	substrate binding site [chemical binding]; other site
365044013399	activation loop (A-loop); other site
365044013400	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
365044013401	Predicted ATPase [General function prediction only]; Region: COG3899
365044013402	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
365044013403	GAF domain; Region: GAF; cl15785
365044013404	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
365044013405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013406	ATP binding site [chemical binding]; other site
365044013407	Mg2+ binding site [ion binding]; other site
365044013408	G-X-G motif; other site
365044013409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013410	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
365044013411	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
365044013412	transketolase; Reviewed; Region: PRK12753
365044013413	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
365044013414	TPP-binding site [chemical binding]; other site
365044013415	dimer interface [polypeptide binding]; other site
365044013416	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
365044013417	PYR/PP interface [polypeptide binding]; other site
365044013418	dimer interface [polypeptide binding]; other site
365044013419	TPP binding site [chemical binding]; other site
365044013420	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
365044013421	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
365044013422	Substrate binding site; other site
365044013423	metal-binding site
365044013424	proline aminopeptidase P II; Provisional; Region: PRK10879
365044013425	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
365044013426	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
365044013427	active site
365044013428	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044013429	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
365044013430	FOG: CBS domain [General function prediction only]; Region: COG0517
365044013431	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
365044013432	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
365044013433	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
365044013434	Walker A/P-loop; other site
365044013435	ATP binding site [chemical binding]; other site
365044013436	Q-loop/lid; other site
365044013437	ABC transporter signature motif; other site
365044013438	Walker B; other site
365044013439	D-loop; other site
365044013440	H-loop/switch region; other site
365044013441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044013442	dimer interface [polypeptide binding]; other site
365044013443	conserved gate region; other site
365044013444	putative PBP binding loops; other site
365044013445	ABC-ATPase subunit interface; other site
365044013446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
365044013447	dimer interface [polypeptide binding]; other site
365044013448	conserved gate region; other site
365044013449	putative PBP binding loops; other site
365044013450	ABC-ATPase subunit interface; other site
365044013451	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
365044013452	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
365044013453	substrate binding pocket [chemical binding]; other site
365044013454	membrane-bound complex binding site; other site
365044013455	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
365044013456	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
365044013457	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
365044013458	putative active site [active]
365044013459	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
365044013460	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
365044013461	allantoate amidohydrolase; Reviewed; Region: PRK12893
365044013462	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
365044013463	active site
365044013464	metal binding site [ion binding]; metal-binding site
365044013465	dimer interface [polypeptide binding]; other site
365044013466	N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569
365044013467	Predicted amidohydrolase [General function prediction only]; Region: COG0388
365044013468	tetramer interface [polypeptide binding]; other site
365044013469	active site
365044013470	catalytic triad [active]
365044013471	dimer interface [polypeptide binding]; other site
365044013472	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
365044013473	Proline dehydrogenase; Region: Pro_dh; cl03282
365044013474	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
365044013475	Glutamate binding site [chemical binding]; other site
365044013476	NAD binding site [chemical binding]; other site
365044013477	catalytic residues [active]
365044013478	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
365044013479	Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434
365044013480	malic enzyme; Reviewed; Region: PRK12862
365044013481	Malic enzyme, N-terminal domain; Region: malic; pfam00390
365044013482	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
365044013483	putative NAD(P) binding site [chemical binding]; other site
365044013484	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
365044013485	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
365044013486	putative RNAase interaction site [polypeptide binding]; other site
365044013487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
365044013488	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
365044013489	SurA N-terminal domain; Region: SurA_N_3; cl07813
365044013490	PPIC-type PPIASE domain; Region: Rotamase; cl08278
365044013491	PPIC-type PPIASE domain; Region: Rotamase; cl08278
365044013492	organic solvent tolerance protein; Provisional; Region: PRK04423
365044013493	Organic solvent tolerance protein; Region: OstA_C; pfam04453
365044013494	Phosphotransferase enzyme family; Region: APH; pfam01636
365044013495	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
365044013496	substrate binding site [chemical binding]; other site
365044013497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
365044013498	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
365044013499	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
365044013500	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
365044013501	active site
365044013502	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
365044013503	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
365044013504	DNA-binding site [nucleotide binding]; DNA binding site
365044013505	UTRA domain; Region: UTRA; cl01230
365044013506	NMT1-like family; Region: NMT1_2; cl15260
365044013507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
365044013508	NMT1-like family; Region: NMT1_2; cl15260
365044013509	hypothetical protein; Provisional; Region: PRK07907
365044013510	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
365044013511	metal binding site [ion binding]; metal-binding site
365044013512	putative dimer interface [polypeptide binding]; other site
365044013513	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
365044013514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
365044013515	active site
365044013516	phosphorylation site [posttranslational modification]
365044013517	intermolecular recognition site; other site
365044013518	dimerization interface [polypeptide binding]; other site
365044013519	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
365044013520	DNA binding residues [nucleotide binding]
365044013521	dimerization interface [polypeptide binding]; other site
365044013522	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
365044013523	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
365044013524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013525	ATP binding site [chemical binding]; other site
365044013526	Mg2+ binding site [ion binding]; other site
365044013527	G-X-G motif; other site
365044013528	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044013529	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044013530	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044013531	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
365044013532	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
365044013533	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044013534	metal-binding site [ion binding]
365044013535	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044013536	metal-binding site [ion binding]
365044013537	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
365044013538	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
365044013539	metal-binding site [ion binding]
365044013540	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
365044013541	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
365044013542	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
365044013543	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
365044013544	DNA binding residues [nucleotide binding]
365044013545	dimer interface [polypeptide binding]; other site
365044013546	copper binding site [ion binding]; other site
365044013547	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
365044013548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
365044013549	Probable transposase; Region: OrfB_IS605; pfam01385
365044013550	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
365044013551	DDE superfamily endonuclease; Region: DDE_4; cl15789
365044013552	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
365044013553	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
365044013554	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
365044013555	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
365044013556	Sulfate transporter family; Region: Sulfate_transp; cl15842
365044013557	Sulfate transporter family; Region: Sulfate_transp; cl15842
365044013558	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
365044013559	Chromate transporter; Region: Chromate_transp; pfam02417
365044013560	Chromate transporter; Region: Chromate_transp; pfam02417
365044013561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
365044013562	S-adenosylmethionine binding site [chemical binding]; other site
365044013563	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
365044013564	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
365044013565	Predicted membrane protein [Function unknown]; Region: COG2119
365044013566	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
365044013567	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
365044013568	yybP-ykoY element as predicted by Rfam (RF00080), score 54.16
365044013569	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
365044013570	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
365044013571	RNA/DNA binding site [nucleotide binding]; other site
365044013572	RRM dimerization site [polypeptide binding]; other site
365044013573	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
365044013574	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
365044013575	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
365044013576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
365044013577	active site
365044013578	motif I; other site
365044013579	motif II; other site
365044013580	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
365044013581	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
365044013582	putative active site [active]
365044013583	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
365044013584	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
365044013585	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
365044013586	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
365044013587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
365044013588	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
365044013589	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
365044013590	ligand binding site [chemical binding]; other site
365044013591	flexible hinge region; other site
365044013592	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
365044013593	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
365044013594	trmE is a tRNA modification GTPase; Region: trmE; cd04164
365044013595	G1 box; other site
365044013596	GTP/Mg2+ binding site [chemical binding]; other site
365044013597	Switch I region; other site
365044013598	G2 box; other site
365044013599	Switch II region; other site
365044013600	G3 box; other site
365044013601	G4 box; other site
365044013602	G5 box; other site
365044013603	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
365044013604	membrane protein insertase; Provisional; Region: PRK01318
365044013605	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
365044013606	Haemolytic domain; Region: Haemolytic; cl00506
365044013607	Ribonuclease P; Region: Ribonuclease_P; cl00457
365044013608	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
365044013609	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
365044013610	DnaA N-terminal domain; Region: DnaA_N; pfam11638
365044013611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
365044013612	Walker A motif; other site
365044013613	ATP binding site [chemical binding]; other site
365044013614	Walker B motif; other site
365044013615	arginine finger; other site
365044013616	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
365044013617	DnaA box-binding interface [nucleotide binding]; other site
365044013618	DNA polymerase III subunit beta; Validated; Region: PRK05643
365044013619	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
365044013620	putative DNA binding surface [nucleotide binding]; other site
365044013621	dimer interface [polypeptide binding]; other site
365044013622	beta-clamp/clamp loader binding surface; other site
365044013623	beta-clamp/translesion DNA polymerase binding surface; other site
365044013624	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
365044013625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
365044013626	ATP binding site [chemical binding]; other site
365044013627	Mg2+ binding site [ion binding]; other site
365044013628	G-X-G motif; other site
365044013629	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
365044013630	anchoring element; other site
365044013631	dimer interface [polypeptide binding]; other site
365044013632	ATP binding site [chemical binding]; other site
365044013633	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
365044013634	active site
365044013635	putative metal-binding site [ion binding]; other site
365044013636	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
365044013637	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
365044013638	active site
365044013639	catalytic site [active]
365044013640	substrate binding site [chemical binding]; other site
365044013641	NeuB family; Region: NeuB; cl00496
365044013642	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793