-- dump date 20120504_155030 -- class Genbank::misc_feature -- table misc_feature_note -- id note 146891000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 146891000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 146891000003 putative DNA binding surface [nucleotide binding]; other site 146891000004 dimer interface [polypeptide binding]; other site 146891000005 beta-clamp/clamp loader binding surface; other site 146891000006 beta-clamp/translesion DNA polymerase binding surface; other site 146891000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 146891000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 146891000009 dimerization interface [polypeptide binding]; other site 146891000010 ATP binding site [chemical binding]; other site 146891000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 146891000012 dimerization interface [polypeptide binding]; other site 146891000013 ATP binding site [chemical binding]; other site 146891000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 146891000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 146891000016 active site 146891000017 tetramer interface [polypeptide binding]; other site 146891000018 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891000019 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 146891000020 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 146891000021 CAP-like domain; other site 146891000022 active site 146891000023 primary dimer interface [polypeptide binding]; other site 146891000024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000025 TPR motif; other site 146891000026 binding surface 146891000027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000028 binding surface 146891000029 TPR motif; other site 146891000030 iron-sulfur cluster binding protein, putative; Region: TIGR00276 146891000031 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 146891000032 Protein of unknown function (DUF502); Region: DUF502; cl01107 146891000033 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 146891000034 putative RNA binding site [nucleotide binding]; other site 146891000035 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 146891000036 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 146891000037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000038 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 146891000039 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 146891000040 argininosuccinate lyase; Provisional; Region: PRK00855 146891000041 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 146891000042 active sites [active] 146891000043 tetramer interface [polypeptide binding]; other site 146891000044 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 146891000045 RNA/DNA binding site [nucleotide binding]; other site 146891000046 RRM dimerization site [polypeptide binding]; other site 146891000047 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 146891000048 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 146891000049 FMN binding site [chemical binding]; other site 146891000050 active site 146891000051 catalytic residues [active] 146891000052 substrate binding site [chemical binding]; other site 146891000053 SelR domain; Region: SelR; cl00369 146891000054 heat shock protein GrpE; Provisional; Region: PRK14140 146891000055 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 146891000056 dimer interface [polypeptide binding]; other site 146891000057 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 146891000058 chaperone protein DnaJ; Provisional; Region: PRK14293 146891000059 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891000060 HSP70 interaction site [polypeptide binding]; other site 146891000061 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 146891000062 substrate binding site [polypeptide binding]; other site 146891000063 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 146891000064 Zn binding sites [ion binding]; other site 146891000065 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 146891000066 dimer interface [polypeptide binding]; other site 146891000067 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 146891000068 CPxP motif; other site 146891000069 Predicted GTPases [General function prediction only]; Region: COG1162 146891000070 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 146891000071 GTPase/OB domain interface [polypeptide binding]; other site 146891000072 GTPase/Zn-binding domain interface [polypeptide binding]; other site 146891000073 GTP/Mg2+ binding site [chemical binding]; other site 146891000074 G4 box; other site 146891000075 G5 box; other site 146891000076 G1 box; other site 146891000077 Switch I region; other site 146891000078 G2 box; other site 146891000079 G3 box; other site 146891000080 Switch II region; other site 146891000081 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 146891000082 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 146891000083 FAD binding domain; Region: FAD_binding_4; pfam01565 146891000084 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 146891000085 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 146891000086 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 146891000087 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 146891000088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 146891000089 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 146891000090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 146891000091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 146891000092 thiamine monophosphate kinase; Provisional; Region: PRK05731 146891000093 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 146891000094 ATP binding site [chemical binding]; other site 146891000095 dimerization interface [polypeptide binding]; other site 146891000096 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 146891000097 active site 146891000098 elongation factor P; Validated; Region: PRK00529 146891000099 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 146891000100 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 146891000101 RNA binding site [nucleotide binding]; other site 146891000102 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 146891000103 RNA binding site [nucleotide binding]; other site 146891000104 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 146891000105 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 146891000106 carboxyltransferase (CT) interaction site; other site 146891000107 biotinylation site [posttranslational modification]; other site 146891000108 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 146891000109 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 146891000110 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891000111 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 146891000112 putative NAD(P) binding site [chemical binding]; other site 146891000113 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 146891000114 active site 146891000115 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 146891000116 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 146891000117 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 146891000118 homodimer interface [polypeptide binding]; other site 146891000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000120 catalytic residue [active] 146891000121 CbiD; Region: CbiD; cl00828 146891000122 GMP synthase; Reviewed; Region: guaA; PRK00074 146891000123 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 146891000124 AMP/PPi binding site [chemical binding]; other site 146891000125 candidate oxyanion hole; other site 146891000126 catalytic triad [active] 146891000127 potential glutamine specificity residues [chemical binding]; other site 146891000128 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 146891000129 ATP Binding subdomain [chemical binding]; other site 146891000130 Ligand Binding sites [chemical binding]; other site 146891000131 Dimerization subdomain; other site 146891000132 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 146891000133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000134 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 146891000135 TPR motif; other site 146891000136 binding surface 146891000137 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 146891000138 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 146891000139 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 146891000140 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 146891000141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 146891000142 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 146891000143 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 146891000144 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 146891000145 Flavin Reductases; Region: FlaRed; cl00801 146891000146 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 146891000147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891000148 Flavin Reductases; Region: FlaRed; cl00801 146891000149 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 146891000150 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 146891000151 motif 1; other site 146891000152 active site 146891000153 motif 2; other site 146891000154 motif 3; other site 146891000155 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 146891000156 DHHA1 domain; Region: DHHA1; pfam02272 146891000157 arginine decarboxylase; Provisional; Region: PRK05354 146891000158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 146891000159 dimer interface [polypeptide binding]; other site 146891000160 active site 146891000161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891000162 catalytic residues [active] 146891000163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 146891000164 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 146891000165 active site 146891000166 multimer interface [polypeptide binding]; other site 146891000167 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 146891000168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000169 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 146891000170 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 146891000171 GatB domain; Region: GatB_Yqey; cl11497 146891000172 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 146891000173 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 146891000174 CoA-binding site [chemical binding]; other site 146891000175 ATP-binding [chemical binding]; other site 146891000176 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 146891000177 heterotetramer interface [polypeptide binding]; other site 146891000178 active site pocket [active] 146891000179 cleavage site 146891000180 Predicted helicase [General function prediction only]; Region: COG4889 146891000181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891000183 ATP binding site [chemical binding]; other site 146891000184 putative Mg++ binding site [ion binding]; other site 146891000185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891000186 nucleotide binding region [chemical binding]; other site 146891000187 ATP-binding site [chemical binding]; other site 146891000188 Helicase associated domain; Region: HA; pfam03457 146891000189 Helicase associated domain; Region: HA; pfam03457 146891000190 Helicase associated domain; Region: HA; pfam03457 146891000191 Helicase associated domain; Region: HA; pfam03457 146891000192 Helicase associated domain; Region: HA; pfam03457 146891000193 Helicase associated domain; Region: HA; pfam03457 146891000194 Helicase associated domain; Region: HA; pfam03457 146891000195 Helicase associated domain; Region: HA; pfam03457 146891000196 Helicase associated domain; Region: HA; pfam03457 146891000197 Helicase associated domain; Region: HA; pfam03457 146891000198 Helicase associated domain; Region: HA; pfam03457 146891000199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000200 TPR motif; other site 146891000201 binding surface 146891000202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000203 binding surface 146891000204 TPR motif; other site 146891000205 YadA-like C-terminal region; Region: YadA; pfam03895 146891000206 ParA-like protein; Provisional; Region: PHA02518 146891000207 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 146891000208 P-loop; other site 146891000209 Magnesium ion binding site [ion binding]; other site 146891000210 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 146891000211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 146891000212 active site 146891000213 catalytic tetrad [active] 146891000214 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 146891000215 THUMP domain; Region: THUMP; cl12076 146891000216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891000217 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 146891000218 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 146891000219 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 146891000220 Walker A/P-loop; other site 146891000221 ATP binding site [chemical binding]; other site 146891000222 Q-loop/lid; other site 146891000223 ABC transporter signature motif; other site 146891000224 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 146891000225 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 146891000226 Q-loop/lid; other site 146891000227 ABC transporter signature motif; other site 146891000228 Walker B; other site 146891000229 D-loop; other site 146891000230 H-loop/switch region; other site 146891000231 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 146891000232 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 146891000233 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 146891000234 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 146891000235 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891000236 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 146891000237 YGGT family; Region: YGGT; cl00508 146891000238 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 146891000239 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 146891000240 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 146891000241 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 146891000242 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 146891000243 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 146891000244 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 146891000245 nucleotide binding site/active site [active] 146891000246 HIT family signature motif; other site 146891000247 catalytic residue [active] 146891000248 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 146891000249 active site 146891000250 catalytic residues [active] 146891000251 metal binding site [ion binding]; metal-binding site 146891000252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 146891000253 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 146891000254 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 146891000255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891000256 catalytic residue [active] 146891000257 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 146891000258 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 146891000259 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 146891000260 Walker A/P-loop; other site 146891000261 ATP binding site [chemical binding]; other site 146891000262 Q-loop/lid; other site 146891000263 ABC transporter signature motif; other site 146891000264 Walker B; other site 146891000265 D-loop; other site 146891000266 H-loop/switch region; other site 146891000267 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 146891000268 putative ABC transporter; Region: ycf24; CHL00085 146891000269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 146891000270 phosphoglucomutase; Region: PLN02307 146891000271 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 146891000272 active site 146891000273 substrate binding site [chemical binding]; other site 146891000274 metal binding site [ion binding]; metal-binding site 146891000275 recombination factor protein RarA; Reviewed; Region: PRK13342 146891000276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000277 Walker A motif; other site 146891000278 ATP binding site [chemical binding]; other site 146891000279 Walker B motif; other site 146891000280 arginine finger; other site 146891000281 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 146891000282 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 146891000283 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 146891000284 catalytic triad [active] 146891000285 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 146891000286 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 146891000287 Active Sites [active] 146891000288 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 146891000289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000291 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 146891000292 transmembrane helices; other site 146891000293 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 146891000294 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 146891000295 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 146891000296 Cation transport protein; Region: TrkH; cl10514 146891000297 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 146891000298 Cation transport protein; Region: TrkH; cl10514 146891000299 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 146891000300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 146891000302 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 146891000303 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 146891000304 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 146891000305 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 146891000306 ABC transporter; Region: ABC_tran_2; pfam12848 146891000307 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 146891000308 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 146891000309 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 146891000310 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 146891000311 protein binding site [polypeptide binding]; other site 146891000312 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 146891000313 putative high light inducible protein; Region: PHA02337 146891000314 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 146891000315 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 146891000316 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 146891000317 active site 146891000318 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 146891000319 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 146891000320 Protein of unknown function (DUF512); Region: DUF512; pfam04459 146891000321 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 146891000322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000323 L-aspartate oxidase; Provisional; Region: PRK07395 146891000324 domain; Region: Succ_DH_flav_C; pfam02910 146891000325 Vitamin K epoxide reductase family; Region: VKOR; cl01729 146891000326 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891000327 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 146891000328 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 146891000329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891000330 FeS/SAM binding site; other site 146891000331 TRAM domain; Region: TRAM; cl01282 146891000332 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 146891000333 Protein of unknown function, DUF482; Region: DUF482; pfam04339 146891000334 FemAB family; Region: FemAB; cl11444 146891000335 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 146891000336 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891000337 active site 146891000338 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891000339 active site 146891000340 shikimate kinase; Reviewed; Region: aroK; PRK00131 146891000341 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 146891000342 ADP binding site [chemical binding]; other site 146891000343 magnesium binding site [ion binding]; other site 146891000344 putative shikimate binding site; other site 146891000345 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 146891000346 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 146891000347 C-terminal domain interface [polypeptide binding]; other site 146891000348 GSH binding site (G-site) [chemical binding]; other site 146891000349 dimer interface [polypeptide binding]; other site 146891000350 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 146891000351 N-terminal domain interface [polypeptide binding]; other site 146891000352 dimer interface [polypeptide binding]; other site 146891000353 substrate binding pocket (H-site) [chemical binding]; other site 146891000354 Protein of unknown function (DUF751); Region: DUF751; pfam05421 146891000355 Ribosome-binding factor A; Region: RBFA; cl00542 146891000356 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 146891000357 active site 146891000358 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 146891000359 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 146891000360 putative hydrophobic ligand binding site [chemical binding]; other site 146891000361 Uncharacterized conserved protein [Function unknown]; Region: COG3349 146891000362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000363 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 146891000364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000365 TPR motif; other site 146891000366 binding surface 146891000367 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891000368 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 146891000369 TIGR01777 family protein; Region: yfcH 146891000370 putative NAD(P) binding site [chemical binding]; other site 146891000371 putative active site [active] 146891000372 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 146891000373 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891000374 HSP70 interaction site [polypeptide binding]; other site 146891000375 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 146891000376 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 146891000377 dimer interface [polypeptide binding]; other site 146891000378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000379 catalytic residue [active] 146891000380 hypothetical protein; Provisional; Region: PRK13683 146891000381 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891000382 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 146891000383 Walker A/P-loop; other site 146891000384 ATP binding site [chemical binding]; other site 146891000385 Q-loop/lid; other site 146891000386 ABC transporter signature motif; other site 146891000387 Walker B; other site 146891000388 D-loop; other site 146891000389 H-loop/switch region; other site 146891000390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 146891000391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891000392 active site 146891000393 phosphorylation site [posttranslational modification] 146891000394 intermolecular recognition site; other site 146891000395 dimerization interface [polypeptide binding]; other site 146891000396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891000397 DNA binding site [nucleotide binding] 146891000398 DNA polymerase III subunit delta'; Validated; Region: PRK07399 146891000399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000400 thymidylate kinase; Validated; Region: tmk; PRK00698 146891000401 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 146891000402 TMP-binding site; other site 146891000403 ATP-binding site [chemical binding]; other site 146891000404 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 146891000405 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 146891000406 metal-binding site [ion binding] 146891000407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 146891000408 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 146891000409 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 146891000410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891000411 binding surface 146891000412 DNA repair protein RadA; Provisional; Region: PRK11823 146891000413 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 146891000414 Walker A motif/ATP binding site; other site 146891000415 ATP binding site [chemical binding]; other site 146891000416 Walker B motif; other site 146891000417 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 146891000418 Ycf27; Reviewed; Region: orf27; CHL00148 146891000419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891000420 active site 146891000421 phosphorylation site [posttranslational modification] 146891000422 intermolecular recognition site; other site 146891000423 dimerization interface [polypeptide binding]; other site 146891000424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891000425 DNA binding site [nucleotide binding] 146891000426 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 146891000427 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 146891000428 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 146891000429 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 146891000430 dimer interface [polypeptide binding]; other site 146891000431 active site 146891000432 CoA binding pocket [chemical binding]; other site 146891000433 Acyl transferase domain; Region: Acyl_transf_1; cl08282 146891000434 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 146891000435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 146891000436 putative acyl-acceptor binding pocket; other site 146891000437 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 146891000438 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 146891000439 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 146891000440 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 146891000441 active site 146891000442 NTP binding site [chemical binding]; other site 146891000443 metal binding triad [ion binding]; metal-binding site 146891000444 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 146891000445 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 146891000446 RNA/DNA binding site [nucleotide binding]; other site 146891000447 RRM dimerization site [polypeptide binding]; other site 146891000448 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 146891000449 active site lid residues [active] 146891000450 substrate binding pocket [chemical binding]; other site 146891000451 catalytic residues [active] 146891000452 substrate-Mg2+ binding site; other site 146891000453 aspartate-rich region 1; other site 146891000454 aspartate-rich region 2; other site 146891000455 Uncharacterized conserved protein [Function unknown]; Region: COG3349 146891000456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000457 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 146891000458 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 146891000459 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 146891000460 Helix-turn-helix domains; Region: HTH; cl00088 146891000461 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 146891000462 putative dimerization interface [polypeptide binding]; other site 146891000463 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 146891000464 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 146891000465 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 146891000466 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 146891000467 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 146891000468 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 146891000469 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 146891000470 ScpA/B protein; Region: ScpA_ScpB; cl00598 146891000471 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 146891000472 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 146891000473 active site 146891000474 Substrate binding site; other site 146891000475 Mg++ binding site; other site 146891000476 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 146891000477 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 146891000478 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 146891000479 FAD binding site [chemical binding]; other site 146891000480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 146891000481 DNA binding residues [nucleotide binding] 146891000482 dimerization interface [polypeptide binding]; other site 146891000483 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 146891000484 putative active site [active] 146891000485 putative metal binding residues [ion binding]; other site 146891000486 signature motif; other site 146891000487 putative dimer interface [polypeptide binding]; other site 146891000488 putative phosphate binding site [ion binding]; other site 146891000489 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 146891000490 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 146891000491 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 146891000492 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 146891000493 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 146891000494 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 146891000495 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 146891000496 NADH dehydrogenase; Region: NADHdh; cl00469 146891000497 citrate synthase; Provisional; Region: PRK14036 146891000498 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 146891000499 oxalacetate binding site [chemical binding]; other site 146891000500 citrylCoA binding site [chemical binding]; other site 146891000501 coenzyme A binding site [chemical binding]; other site 146891000502 catalytic triad [active] 146891000503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 146891000504 active site residue [active] 146891000505 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 146891000506 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 146891000507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000508 catalytic residue [active] 146891000509 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 146891000510 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 146891000511 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 146891000512 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 146891000513 ligand-binding site [chemical binding]; other site 146891000514 AIR carboxylase; Region: AIRC; cl00310 146891000515 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 146891000516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891000517 S-adenosylmethionine binding site [chemical binding]; other site 146891000518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891000519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 146891000520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891000521 active site 146891000522 phosphorylation site [posttranslational modification] 146891000523 intermolecular recognition site; other site 146891000524 dimerization interface [polypeptide binding]; other site 146891000525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 146891000526 DNA binding residues [nucleotide binding] 146891000527 dimerization interface [polypeptide binding]; other site 146891000528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891000529 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 146891000530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891000531 catalytic residue [active] 146891000532 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 146891000533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891000534 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 146891000535 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 146891000536 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 146891000537 active site 146891000538 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 146891000539 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 146891000540 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 146891000541 active site 146891000542 UbiA prenyltransferase family; Region: UbiA; cl00337 146891000543 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 146891000544 chorismate binding enzyme; Region: Chorismate_bind; cl10555 146891000545 glutathione synthetase; Provisional; Region: PRK05246 146891000546 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 146891000547 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891000548 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 146891000549 GSH binding site [chemical binding]; other site 146891000550 catalytic residues [active] 146891000551 peptide chain release factor 2; Validated; Region: prfB; PRK00578 146891000552 RF-1 domain; Region: RF-1; cl02875 146891000553 RF-1 domain; Region: RF-1; cl02875 146891000554 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 146891000555 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 146891000556 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 146891000557 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 146891000558 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 146891000559 glutamine binding [chemical binding]; other site 146891000560 catalytic triad [active] 146891000561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891000562 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 146891000563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891000564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000565 homodimer interface [polypeptide binding]; other site 146891000566 catalytic residue [active] 146891000567 arginine-tRNA ligase; Region: PLN02286 146891000568 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 146891000569 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 146891000570 active site 146891000571 HIGH motif; other site 146891000572 KMSK motif region; other site 146891000573 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 146891000574 tRNA binding surface [nucleotide binding]; other site 146891000575 anticodon binding site; other site 146891000576 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 146891000577 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 146891000578 dimerization interface [polypeptide binding]; other site 146891000579 active site 146891000580 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 146891000581 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 146891000582 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 146891000583 G1 box; other site 146891000584 GTP/Mg2+ binding site [chemical binding]; other site 146891000585 Switch I region; other site 146891000586 G2 box; other site 146891000587 Switch II region; other site 146891000588 G3 box; other site 146891000589 G4 box; other site 146891000590 G5 box; other site 146891000591 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 146891000592 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 146891000593 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 146891000594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 146891000595 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 146891000596 synthetase active site [active] 146891000597 NTP binding site [chemical binding]; other site 146891000598 metal binding site [ion binding]; metal-binding site 146891000599 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 146891000600 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 146891000601 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 146891000602 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 146891000603 Walker A/P-loop; other site 146891000604 ATP binding site [chemical binding]; other site 146891000605 Q-loop/lid; other site 146891000606 ABC transporter signature motif; other site 146891000607 Walker B; other site 146891000608 D-loop; other site 146891000609 H-loop/switch region; other site 146891000610 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 146891000611 Walker A/P-loop; other site 146891000612 ATP binding site [chemical binding]; other site 146891000613 Q-loop/lid; other site 146891000614 ABC transporter signature motif; other site 146891000615 Walker B; other site 146891000616 D-loop; other site 146891000617 H-loop/switch region; other site 146891000618 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 146891000619 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891000620 RNA binding surface [nucleotide binding]; other site 146891000621 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 146891000622 active site 146891000623 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 146891000624 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 146891000625 GTP/Mg2+ binding site [chemical binding]; other site 146891000626 G4 box; other site 146891000627 G5 box; other site 146891000628 G1 box; other site 146891000629 Switch I region; other site 146891000630 G2 box; other site 146891000631 G3 box; other site 146891000632 Switch II region; other site 146891000633 Phosphoglycerate kinase; Region: PGK; pfam00162 146891000634 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 146891000635 substrate binding site [chemical binding]; other site 146891000636 hinge regions; other site 146891000637 ADP binding site [chemical binding]; other site 146891000638 catalytic site [active] 146891000639 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 146891000640 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 146891000641 active site 146891000642 homodimer interface [polypeptide binding]; other site 146891000643 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 146891000644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891000645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000646 homodimer interface [polypeptide binding]; other site 146891000647 catalytic residue [active] 146891000648 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 146891000649 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 146891000650 active site 146891000651 catalytic residues [active] 146891000652 FMN binding site [chemical binding]; other site 146891000653 quinone interaction residues [chemical binding]; other site 146891000654 substrate binding site [chemical binding]; other site 146891000655 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 146891000656 RNA/DNA hybrid binding site [nucleotide binding]; other site 146891000657 active site 146891000658 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 146891000659 L11 interface [polypeptide binding]; other site 146891000660 putative EF-Tu interaction site [polypeptide binding]; other site 146891000661 putative EF-G interaction site [polypeptide binding]; other site 146891000662 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 146891000663 23S rRNA interface [nucleotide binding]; other site 146891000664 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 146891000665 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 146891000666 mRNA/rRNA interface [nucleotide binding]; other site 146891000667 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 146891000668 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 146891000669 23S rRNA interface [nucleotide binding]; other site 146891000670 L7/L12 interface [polypeptide binding]; other site 146891000671 putative thiostrepton binding site; other site 146891000672 L25 interface [polypeptide binding]; other site 146891000673 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 146891000674 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 146891000675 putative homodimer interface [polypeptide binding]; other site 146891000676 KOW motif; Region: KOW; cl00354 146891000677 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 146891000678 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 146891000679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000680 Walker A motif; other site 146891000681 ATP binding site [chemical binding]; other site 146891000682 Walker B motif; other site 146891000683 arginine finger; other site 146891000684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000685 Walker A motif; other site 146891000686 ATP binding site [chemical binding]; other site 146891000687 Walker B motif; other site 146891000688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 146891000689 enolase; Provisional; Region: eno; PRK00077 146891000690 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 146891000691 dimer interface [polypeptide binding]; other site 146891000692 metal binding site [ion binding]; metal-binding site 146891000693 substrate binding pocket [chemical binding]; other site 146891000694 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 146891000695 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 146891000696 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 146891000697 active site 146891000698 ATP binding site [chemical binding]; other site 146891000699 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 146891000700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000701 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 146891000702 Nitrogen regulatory protein P-II; Region: P-II; cl00412 146891000703 Domain of unknown function (DUF897); Region: DUF897; cl01312 146891000704 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 146891000705 Permease family; Region: Xan_ur_permease; cl00967 146891000706 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 146891000707 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 146891000708 dimer interface [polypeptide binding]; other site 146891000709 allosteric magnesium binding site [ion binding]; other site 146891000710 active site 146891000711 aspartate-rich active site metal binding site; other site 146891000712 Schiff base residues; other site 146891000713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 146891000714 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 146891000715 active site 146891000716 metal binding site [ion binding]; metal-binding site 146891000717 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 146891000718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000719 Walker A/P-loop; other site 146891000720 ATP binding site [chemical binding]; other site 146891000721 Q-loop/lid; other site 146891000722 ABC transporter signature motif; other site 146891000723 Walker B; other site 146891000724 D-loop; other site 146891000725 H-loop/switch region; other site 146891000726 Smr domain; Region: Smr; cl02619 146891000727 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 146891000728 GTP1/OBG; Region: GTP1_OBG; pfam01018 146891000729 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 146891000730 G1 box; other site 146891000731 GTP/Mg2+ binding site [chemical binding]; other site 146891000732 Switch I region; other site 146891000733 G2 box; other site 146891000734 G3 box; other site 146891000735 Switch II region; other site 146891000736 G4 box; other site 146891000737 CP12 domain; Region: CP12; cl14670 146891000738 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 146891000739 putative dimer interface [polypeptide binding]; other site 146891000740 N-terminal domain interface [polypeptide binding]; other site 146891000741 putative substrate binding pocket (H-site) [chemical binding]; other site 146891000742 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 146891000743 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 146891000744 active site 146891000745 Zn binding site [ion binding]; other site 146891000746 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 146891000747 protein I interface; other site 146891000748 D2 interface; other site 146891000749 protein T interface; other site 146891000750 chlorophyll binding site; other site 146891000751 beta carotene binding site; other site 146891000752 pheophytin binding site; other site 146891000753 manganese-stabilizing polypeptide interface; other site 146891000754 CP43 interface; other site 146891000755 protein L interface; other site 146891000756 oxygen evolving complex binding site; other site 146891000757 bromide binding site; other site 146891000758 quinone binding site; other site 146891000759 Fe binding site [ion binding]; other site 146891000760 core light harvesting interface; other site 146891000761 cytochrome b559 alpha subunit interface; other site 146891000762 cytochrome c-550 interface; other site 146891000763 protein J interface; other site 146891000764 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 146891000765 Tetramer interface [polypeptide binding]; other site 146891000766 active site 146891000767 FMN-binding site [chemical binding]; other site 146891000768 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 146891000769 active site 146891000770 intersubunit interface [polypeptide binding]; other site 146891000771 catalytic residue [active] 146891000772 FtsH Extracellular; Region: FtsH_ext; pfam06480 146891000773 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 146891000774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891000775 Walker A motif; other site 146891000776 ATP binding site [chemical binding]; other site 146891000777 Walker B motif; other site 146891000778 arginine finger; other site 146891000779 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891000780 ATP-sulfurylase; Region: ATPS; cd00517 146891000781 active site 146891000782 HXXH motif; other site 146891000783 flexible loop; other site 146891000784 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 146891000785 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 146891000786 Flavoprotein; Region: Flavoprotein; cl08021 146891000787 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 146891000788 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 146891000789 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 146891000790 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 146891000791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000792 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 146891000793 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 146891000794 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 146891000795 Fatty acid desaturase; Region: FA_desaturase; pfam00487 146891000796 putative di-iron ligands [ion binding]; other site 146891000797 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 146891000798 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891000799 active site 146891000800 HIGH motif; other site 146891000801 nucleotide binding site [chemical binding]; other site 146891000802 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 146891000803 active site 146891000804 KMSKS motif; other site 146891000805 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 146891000806 tRNA binding surface [nucleotide binding]; other site 146891000807 anticodon binding site; other site 146891000808 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 146891000809 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 146891000810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891000811 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 146891000812 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 146891000813 active site 146891000814 substrate binding site [chemical binding]; other site 146891000815 metal binding site [ion binding]; metal-binding site 146891000816 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891000817 Thymidylate synthase complementing protein; Region: Thy1; cl03630 146891000818 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 146891000819 trimer interface [polypeptide binding]; other site 146891000820 active site 146891000821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000822 Walker A motif; other site 146891000823 ATP binding site [chemical binding]; other site 146891000824 Walker B motif; other site 146891000825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 146891000826 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 146891000827 ligand binding site [chemical binding]; other site 146891000828 flexible hinge region; other site 146891000829 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 146891000830 putative switch regulator; other site 146891000831 non-specific DNA interactions [nucleotide binding]; other site 146891000832 DNA binding site [nucleotide binding] 146891000833 sequence specific DNA binding site [nucleotide binding]; other site 146891000834 putative cAMP binding site [chemical binding]; other site 146891000835 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 146891000836 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 146891000837 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 146891000838 putative active site [active] 146891000839 catalytic residue [active] 146891000840 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 146891000841 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 146891000842 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 146891000843 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 146891000844 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 146891000845 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 146891000846 substrate binding site [chemical binding]; other site 146891000847 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 146891000848 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 146891000849 substrate binding site [chemical binding]; other site 146891000850 ligand binding site [chemical binding]; other site 146891000851 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 146891000852 competence damage-inducible protein A; Provisional; Region: PRK00549 146891000853 putative MPT binding site; other site 146891000854 Competence-damaged protein; Region: CinA; cl00666 146891000855 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 146891000856 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 146891000857 dimer interface [polypeptide binding]; other site 146891000858 glycine-pyridoxal phosphate binding site [chemical binding]; other site 146891000859 active site 146891000860 folate binding site [chemical binding]; other site 146891000861 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 146891000862 integral membrane protein MviN; Region: mviN; TIGR01695 146891000863 Sugar fermentation stimulation protein; Region: SfsA; cl00647 146891000864 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 146891000865 LytB protein; Region: LYTB; cl00507 146891000866 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 146891000867 DoxX; Region: DoxX; cl00976 146891000868 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 146891000869 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 146891000870 purine monophosphate binding site [chemical binding]; other site 146891000871 dimer interface [polypeptide binding]; other site 146891000872 putative catalytic residues [active] 146891000873 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 146891000874 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 146891000875 Predicted esterase [General function prediction only]; Region: COG0400 146891000876 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 146891000877 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 146891000878 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 146891000879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 146891000880 dimer interface [polypeptide binding]; other site 146891000881 phosphorylation site [posttranslational modification] 146891000882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891000883 ATP binding site [chemical binding]; other site 146891000884 Mg2+ binding site [ion binding]; other site 146891000885 G-X-G motif; other site 146891000886 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 146891000887 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 146891000888 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 146891000889 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891000890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891000891 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 146891000892 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 146891000893 Domain of unknown function DUF21; Region: DUF21; pfam01595 146891000894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 146891000895 Transporter associated domain; Region: CorC_HlyC; cl08393 146891000896 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891000897 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 146891000898 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 146891000899 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 146891000900 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 146891000901 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 146891000902 active site 146891000903 substrate binding site [chemical binding]; other site 146891000904 metal binding site [ion binding]; metal-binding site 146891000905 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 146891000906 active site 146891000907 dimerization interface [polypeptide binding]; other site 146891000908 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 146891000909 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 146891000910 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 146891000911 putative active site pocket [active] 146891000912 4-fold oligomerization interface [polypeptide binding]; other site 146891000913 metal binding residues [ion binding]; metal-binding site 146891000914 3-fold/trimer interface [polypeptide binding]; other site 146891000915 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 146891000916 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 146891000917 NAD binding site [chemical binding]; other site 146891000918 homotetramer interface [polypeptide binding]; other site 146891000919 homodimer interface [polypeptide binding]; other site 146891000920 substrate binding site [chemical binding]; other site 146891000921 active site 146891000922 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 146891000923 putative catalytic residue [active] 146891000924 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 146891000925 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 146891000926 inhibitor-cofactor binding pocket; inhibition site 146891000927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891000928 catalytic residue [active] 146891000929 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 146891000930 DNA photolyase; Region: DNA_photolyase; pfam00875 146891000931 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 146891000932 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 146891000933 dimer interface [polypeptide binding]; other site 146891000934 ADP-ribose binding site [chemical binding]; other site 146891000935 active site 146891000936 nudix motif; other site 146891000937 metal binding site [ion binding]; metal-binding site 146891000938 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 146891000939 catalytic center binding site [active] 146891000940 ATP binding site [chemical binding]; other site 146891000941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000942 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 146891000943 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 146891000944 metal ion-dependent adhesion site (MIDAS); other site 146891000945 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 146891000946 mce related protein; Region: MCE; cl15431 146891000947 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891000948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000949 Walker A/P-loop; other site 146891000950 ATP binding site [chemical binding]; other site 146891000951 Q-loop/lid; other site 146891000952 ABC transporter signature motif; other site 146891000953 Walker B; other site 146891000954 D-loop; other site 146891000955 H-loop/switch region; other site 146891000956 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 146891000957 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 146891000958 phosphate binding site [ion binding]; other site 146891000959 putative substrate binding pocket [chemical binding]; other site 146891000960 dimer interface [polypeptide binding]; other site 146891000961 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 146891000962 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 146891000963 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 146891000964 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 146891000965 Rubredoxin; Region: Rubredoxin; pfam00301 146891000966 iron binding site [ion binding]; other site 146891000967 Ycf48-like protein; Provisional; Region: PRK13684 146891000968 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 146891000969 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 146891000970 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 146891000971 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 146891000972 PsbL protein; Region: PsbL; cl03581 146891000973 PsbJ; Region: PsbJ; cl09469 146891000974 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 146891000975 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 146891000976 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 146891000977 selenium donor protein; Region: selD; TIGR00476 146891000978 dimerization interface [polypeptide binding]; other site 146891000979 ATP binding site [chemical binding]; other site 146891000980 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 146891000981 active site 146891000982 NTP binding site [chemical binding]; other site 146891000983 metal binding triad [ion binding]; metal-binding site 146891000984 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 146891000985 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 146891000986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891000987 Phycobilisome protein; Region: Phycobilisome; cl08227 146891000988 CpeS-like protein; Region: CpeS; pfam09367 146891000989 D-xylulose kinase; Region: XylB; TIGR01312 146891000990 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 146891000991 N- and C-terminal domain interface [polypeptide binding]; other site 146891000992 active site 146891000993 MgATP binding site [chemical binding]; other site 146891000994 catalytic site [active] 146891000995 metal binding site [ion binding]; metal-binding site 146891000996 carbohydrate binding site [chemical binding]; other site 146891000997 S-adenosylmethionine synthetase; Validated; Region: PRK05250 146891000998 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 146891000999 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 146891001000 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 146891001001 30S ribosomal protein S1; Reviewed; Region: PRK07400 146891001002 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 146891001003 RNA binding site [nucleotide binding]; other site 146891001004 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 146891001005 RNA binding site [nucleotide binding]; other site 146891001006 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 146891001007 RNA binding site [nucleotide binding]; other site 146891001008 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 146891001009 ATP cone domain; Region: ATP-cone; pfam03477 146891001010 Photosystem II reaction centre T protein; Region: PsbT; cl11601 146891001011 Photosystem II protein; Region: PSII; cl08223 146891001012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891001013 catalytic loop [active] 146891001014 iron binding site [ion binding]; other site 146891001015 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 146891001016 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 146891001017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001018 S-adenosylmethionine binding site [chemical binding]; other site 146891001019 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 146891001020 Septum formation topological specificity factor MinE; Region: MinE; cl00538 146891001021 septum site-determining protein MinD; Region: minD_bact; TIGR01968 146891001022 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 146891001023 P-loop; other site 146891001024 ADP binding residues [chemical binding]; other site 146891001025 Switch I; other site 146891001026 Switch II; other site 146891001027 septum formation inhibitor; Reviewed; Region: minC; PRK00513 146891001028 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 146891001029 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 146891001030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 146891001031 Zn2+ binding site [ion binding]; other site 146891001032 Mg2+ binding site [ion binding]; other site 146891001033 carboxyl-terminal processing protease; Provisional; Region: PLN00049 146891001034 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 146891001035 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 146891001036 protein binding site [polypeptide binding]; other site 146891001037 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 146891001038 Catalytic dyad [active] 146891001039 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 146891001040 Qi binding site; other site 146891001041 intrachain domain interface; other site 146891001042 interchain domain interface [polypeptide binding]; other site 146891001043 heme bH binding site [chemical binding]; other site 146891001044 heme bL binding site [chemical binding]; other site 146891001045 Qo binding site; other site 146891001046 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 146891001047 interchain domain interface [polypeptide binding]; other site 146891001048 intrachain domain interface; other site 146891001049 Qi binding site; other site 146891001050 Qo binding site; other site 146891001051 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 146891001052 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 146891001053 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 146891001054 DNA binding site [nucleotide binding] 146891001055 catalytic residue [active] 146891001056 H2TH interface [polypeptide binding]; other site 146891001057 putative catalytic residues [active] 146891001058 turnover-facilitating residue; other site 146891001059 intercalation triad [nucleotide binding]; other site 146891001060 8OG recognition residue [nucleotide binding]; other site 146891001061 putative reading head residues; other site 146891001062 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 146891001063 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 146891001064 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 146891001065 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 146891001066 putative peptidoglycan binding site; other site 146891001067 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 146891001068 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 146891001069 putative peptidoglycan binding site; other site 146891001070 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 146891001071 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 146891001072 NAD(P) binding site [chemical binding]; other site 146891001073 catalytic residues [active] 146891001074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891001075 Coenzyme A binding pocket [chemical binding]; other site 146891001076 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 146891001077 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 146891001078 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 146891001079 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 146891001080 dinuclear metal binding motif [ion binding]; other site 146891001081 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 146891001082 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 146891001083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001084 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 146891001085 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 146891001086 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 146891001087 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 146891001088 catalytic triad [active] 146891001089 ankyrin repeat protein; Provisional; Region: PHA02874 146891001090 RF-1 domain; Region: RF-1; cl02875 146891001091 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891001092 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 146891001093 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 146891001094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 146891001095 active site 146891001096 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 146891001097 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 146891001098 DNA photolyase; Region: DNA_photolyase; pfam00875 146891001099 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 146891001100 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 146891001101 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 146891001102 substrate binding site [chemical binding]; other site 146891001103 dimer interface [polypeptide binding]; other site 146891001104 ATP binding site [chemical binding]; other site 146891001105 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 146891001106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 146891001107 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 146891001108 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 146891001109 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 146891001110 putative NAD(P) binding site [chemical binding]; other site 146891001111 active site 146891001112 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 146891001113 putative high light inducible protein; Region: PHA02337 146891001114 putative high light inducible protein; Region: PHA02337 146891001115 Protein of unknown function (DUF541); Region: SIMPL; cl01077 146891001116 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 146891001117 additional DNA contacts [nucleotide binding]; other site 146891001118 mismatch recognition site; other site 146891001119 active site 146891001120 zinc binding site [ion binding]; other site 146891001121 DNA intercalation site [nucleotide binding]; other site 146891001122 Z1 domain; Region: Z1; pfam10593 146891001123 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 146891001124 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 146891001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891001126 cofactor binding site; other site 146891001127 DNA binding site [nucleotide binding] 146891001128 substrate interaction site [chemical binding]; other site 146891001129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891001130 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 146891001131 Phage integrase family; Region: Phage_integrase; pfam00589 146891001132 DNA binding site [nucleotide binding] 146891001133 Int/Topo IB signature motif; other site 146891001134 active site 146891001135 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 146891001136 active site 146891001137 trimer interface [polypeptide binding]; other site 146891001138 dimer interface [polypeptide binding]; other site 146891001139 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 146891001140 active site 146891001141 dinuclear metal binding site [ion binding]; other site 146891001142 dimerization interface [polypeptide binding]; other site 146891001143 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 146891001144 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 146891001145 GTP-binding protein Der; Reviewed; Region: PRK00093 146891001146 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 146891001147 G1 box; other site 146891001148 GTP/Mg2+ binding site [chemical binding]; other site 146891001149 Switch I region; other site 146891001150 G2 box; other site 146891001151 Switch II region; other site 146891001152 G3 box; other site 146891001153 G4 box; other site 146891001154 G5 box; other site 146891001155 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 146891001156 G1 box; other site 146891001157 GTP/Mg2+ binding site [chemical binding]; other site 146891001158 Switch I region; other site 146891001159 G2 box; other site 146891001160 G3 box; other site 146891001161 Switch II region; other site 146891001162 G4 box; other site 146891001163 G5 box; other site 146891001164 Cobalt transport protein; Region: CbiQ; cl00463 146891001165 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 146891001166 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 146891001167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891001168 catalytic residue [active] 146891001169 Protein of unknown function (DUF552); Region: DUF552; cl00775 146891001170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001171 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 146891001172 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 146891001173 Recombination protein O N terminal; Region: RecO_N; pfam11967 146891001174 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 146891001175 Recombination protein O C terminal; Region: RecO_C; pfam02565 146891001176 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 146891001177 catalytic residue [active] 146891001178 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 146891001179 30S subunit binding site; other site 146891001180 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 146891001181 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 146891001182 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 146891001183 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 146891001184 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 146891001185 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 146891001186 E3 interaction surface; other site 146891001187 lipoyl attachment site [posttranslational modification]; other site 146891001188 e3 binding domain; Region: E3_binding; pfam02817 146891001189 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 146891001190 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 146891001191 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 146891001192 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 146891001193 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 146891001194 dimer interface [polypeptide binding]; other site 146891001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001196 catalytic residue [active] 146891001197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891001198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891001199 catalytic residue [active] 146891001200 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 146891001201 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 146891001202 homodimer interface [polypeptide binding]; other site 146891001203 substrate-cofactor binding pocket; other site 146891001204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001205 catalytic residue [active] 146891001206 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 146891001207 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 146891001208 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891001209 RNA binding surface [nucleotide binding]; other site 146891001210 Domain of unknown function DUF37; Region: DUF37; cl00506 146891001211 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891001212 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 146891001213 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 146891001214 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 146891001215 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 146891001216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001217 NAD(P) binding site [chemical binding]; other site 146891001218 active site 146891001219 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 146891001220 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891001221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891001222 catalytic residue [active] 146891001223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001224 S-adenosylmethionine binding site [chemical binding]; other site 146891001225 NifU-like domain; Region: NifU; cl00484 146891001226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001227 Predicted dehydrogenase [General function prediction only]; Region: COG0579 146891001228 GTP-binding protein LepA; Provisional; Region: PRK05433 146891001229 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 146891001230 G1 box; other site 146891001231 putative GEF interaction site [polypeptide binding]; other site 146891001232 GTP/Mg2+ binding site [chemical binding]; other site 146891001233 Switch I region; other site 146891001234 G2 box; other site 146891001235 G3 box; other site 146891001236 Switch II region; other site 146891001237 G4 box; other site 146891001238 G5 box; other site 146891001239 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 146891001240 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 146891001241 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 146891001242 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 146891001243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891001244 dimer interface [polypeptide binding]; other site 146891001245 conserved gate region; other site 146891001246 ABC-ATPase subunit interface; other site 146891001247 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 146891001248 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 146891001249 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 146891001250 Protein of unknown function, DUF393; Region: DUF393; cl01136 146891001251 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 146891001252 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 146891001253 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 146891001254 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 146891001255 16S rRNA methyltransferase B; Provisional; Region: PRK14901 146891001256 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 146891001257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001258 S-adenosylmethionine binding site [chemical binding]; other site 146891001259 Transglycosylase; Region: Transgly; cl07896 146891001260 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 146891001261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 146891001262 UbiA prenyltransferase family; Region: UbiA; cl00337 146891001263 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 146891001264 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 146891001265 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 146891001266 substrate binding site [chemical binding]; other site 146891001267 glutamase interaction surface [polypeptide binding]; other site 146891001268 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 146891001269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001270 S-adenosylmethionine binding site [chemical binding]; other site 146891001271 Protein of unknown function (DUF721); Region: DUF721; cl02324 146891001272 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 146891001273 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 146891001274 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 146891001275 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 146891001276 Walker A/P-loop; other site 146891001277 ATP binding site [chemical binding]; other site 146891001278 Q-loop/lid; other site 146891001279 ABC transporter signature motif; other site 146891001280 Walker B; other site 146891001281 D-loop; other site 146891001282 H-loop/switch region; other site 146891001283 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 146891001284 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 146891001285 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 146891001286 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 146891001287 active site 146891001288 interdomain interaction site; other site 146891001289 putative metal-binding site [ion binding]; other site 146891001290 nucleotide binding site [chemical binding]; other site 146891001291 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 146891001292 domain I; other site 146891001293 phosphate binding site [ion binding]; other site 146891001294 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 146891001295 domain II; other site 146891001296 domain III; other site 146891001297 nucleotide binding site [chemical binding]; other site 146891001298 DNA binding groove [nucleotide binding] 146891001299 catalytic site [active] 146891001300 domain IV; other site 146891001301 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 146891001302 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 146891001303 active site pocket [active] 146891001304 putative dimer interface [polypeptide binding]; other site 146891001305 putative cataytic base [active] 146891001306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 146891001307 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 146891001308 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 146891001309 active site 146891001310 catalytic tetrad [active] 146891001311 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 146891001312 Lumazine binding domain; Region: Lum_binding; pfam00677 146891001313 Lumazine binding domain; Region: Lum_binding; pfam00677 146891001314 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 146891001315 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 146891001316 Subunit I/III interface [polypeptide binding]; other site 146891001317 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 146891001318 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 146891001319 D-pathway; other site 146891001320 Low-spin heme binding site [chemical binding]; other site 146891001321 Putative water exit pathway; other site 146891001322 Binuclear center (active site) [active] 146891001323 K-pathway; other site 146891001324 Putative proton exit pathway; other site 146891001325 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 146891001326 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 146891001327 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 146891001328 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 146891001329 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 146891001330 UbiA prenyltransferase family; Region: UbiA; cl00337 146891001331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891001332 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 146891001333 Walker A/P-loop; other site 146891001334 ATP binding site [chemical binding]; other site 146891001335 Q-loop/lid; other site 146891001336 ABC transporter signature motif; other site 146891001337 Walker B; other site 146891001338 D-loop; other site 146891001339 H-loop/switch region; other site 146891001340 ABC-2 type transporter; Region: ABC2_membrane; cl11417 146891001341 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 146891001342 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 146891001343 ring oligomerisation interface [polypeptide binding]; other site 146891001344 ATP/Mg binding site [chemical binding]; other site 146891001345 stacking interactions; other site 146891001346 hinge regions; other site 146891001347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 146891001348 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 146891001349 NAD(P) binding site [chemical binding]; other site 146891001350 homotetramer interface [polypeptide binding]; other site 146891001351 homodimer interface [polypeptide binding]; other site 146891001352 active site 146891001353 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 146891001354 substrate binding site; other site 146891001355 dimer interface; other site 146891001356 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 146891001357 dimer interface [polypeptide binding]; other site 146891001358 catalytic triad [active] 146891001359 UbiA prenyltransferase family; Region: UbiA; cl00337 146891001360 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 146891001361 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 146891001362 Alba; Region: Alba; cl00682 146891001363 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 146891001364 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 146891001365 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 146891001366 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 146891001367 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 146891001368 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 146891001369 cytochrome b subunit interaction site [polypeptide binding]; other site 146891001370 [2Fe-2S] cluster binding site [ion binding]; other site 146891001371 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 146891001372 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 146891001373 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 146891001374 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 146891001375 Domain of unknown function (DUF814); Region: DUF814; pfam05670 146891001376 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 146891001377 catalytic site [active] 146891001378 G-X2-G-X-G-K; other site 146891001379 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 146891001380 UGMP family protein; Validated; Region: PRK09604 146891001381 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 146891001382 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 146891001383 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 146891001384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891001385 active site 146891001386 HIGH motif; other site 146891001387 nucleotide binding site [chemical binding]; other site 146891001388 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 146891001389 active site 146891001390 KMSKS motif; other site 146891001391 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 146891001392 methionine aminopeptidase; Provisional; Region: PRK08671 146891001393 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 146891001394 active site 146891001395 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 146891001396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001397 NAD(P) binding site [chemical binding]; other site 146891001398 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 146891001399 DRTGG domain; Region: DRTGG; cl12147 146891001400 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 146891001401 Protein of unknown function (DUF520); Region: DUF520; cl00723 146891001402 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 146891001403 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 146891001404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 146891001405 inhibitor-cofactor binding pocket; inhibition site 146891001406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001407 catalytic residue [active] 146891001408 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 146891001409 putative phosphate binding site [ion binding]; other site 146891001410 putative catalytic site [active] 146891001411 active site 146891001412 metal binding site A [ion binding]; metal-binding site 146891001413 DNA binding site [nucleotide binding] 146891001414 putative AP binding site [nucleotide binding]; other site 146891001415 putative metal binding site B [ion binding]; other site 146891001416 Protein of unknown function DUF111; Region: DUF111; cl03398 146891001417 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 146891001418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891001419 dimer interface [polypeptide binding]; other site 146891001420 conserved gate region; other site 146891001421 putative PBP binding loops; other site 146891001422 ABC-ATPase subunit interface; other site 146891001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891001424 dimer interface [polypeptide binding]; other site 146891001425 conserved gate region; other site 146891001426 putative PBP binding loops; other site 146891001427 ABC-ATPase subunit interface; other site 146891001428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891001429 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 146891001430 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 146891001431 aromatic arch; other site 146891001432 DCoH dimer interaction site [polypeptide binding]; other site 146891001433 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 146891001434 DCoH tetramer interaction site [polypeptide binding]; other site 146891001435 substrate binding site [chemical binding]; other site 146891001436 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 146891001437 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 146891001438 dimer interface [polypeptide binding]; other site 146891001439 substrate binding site [chemical binding]; other site 146891001440 metal binding sites [ion binding]; metal-binding site 146891001441 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 146891001442 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 146891001443 domain interfaces; other site 146891001444 active site 146891001445 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891001446 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891001447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891001448 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891001449 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891001450 DNA binding residues [nucleotide binding] 146891001451 primosome assembly protein PriA; Validated; Region: PRK05580 146891001452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891001453 ATP binding site [chemical binding]; other site 146891001454 putative Mg++ binding site [ion binding]; other site 146891001455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891001456 ATP-binding site [chemical binding]; other site 146891001457 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 146891001458 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 146891001459 feedback inhibition sensing region; other site 146891001460 homohexameric interface [polypeptide binding]; other site 146891001461 nucleotide binding site [chemical binding]; other site 146891001462 N-acetyl-L-glutamate binding site [chemical binding]; other site 146891001463 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 146891001464 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 146891001465 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 146891001466 ssDNA binding site [nucleotide binding]; other site 146891001467 dimer interface [polypeptide binding]; other site 146891001468 tetramer (dimer of dimers) interface [polypeptide binding]; other site 146891001469 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 146891001470 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 146891001471 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 146891001472 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891001473 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 146891001474 substrate binding site [chemical binding]; other site 146891001475 ATP binding site [chemical binding]; other site 146891001476 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 146891001477 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 146891001478 GDP-binding site [chemical binding]; other site 146891001479 ACT binding site; other site 146891001480 IMP binding site; other site 146891001481 photosystem II protein Psb27; Provisional; Region: PLN00064; cl11841 146891001482 prolyl-tRNA synthetase; Provisional; Region: PRK09194 146891001483 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 146891001484 dimer interface [polypeptide binding]; other site 146891001485 motif 1; other site 146891001486 active site 146891001487 motif 2; other site 146891001488 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 146891001489 putative deacylase active site [active] 146891001490 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 146891001491 motif 3; other site 146891001492 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 146891001493 anticodon binding site; other site 146891001494 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 146891001495 dimer interface [polypeptide binding]; other site 146891001496 substrate binding site [chemical binding]; other site 146891001497 metal binding sites [ion binding]; metal-binding site 146891001498 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 146891001499 ArsC family; Region: ArsC; pfam03960 146891001500 putative ArsC-like catalytic residues; other site 146891001501 putative TRX-like catalytic residues [active] 146891001502 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 146891001503 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 146891001504 Catalytic site [active] 146891001505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 146891001506 catalytic core [active] 146891001507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 146891001508 catalytic core [active] 146891001509 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 146891001510 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 146891001511 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 146891001512 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 146891001513 transaldolase-like protein; Provisional; Region: PTZ00411 146891001514 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 146891001515 active site 146891001516 dimer interface [polypeptide binding]; other site 146891001517 catalytic residue [active] 146891001518 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 146891001519 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 146891001520 ribosome recycling factor; Reviewed; Region: frr; PRK00083 146891001521 hinge region; other site 146891001522 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 146891001523 putative nucleotide binding site [chemical binding]; other site 146891001524 uridine monophosphate binding site [chemical binding]; other site 146891001525 homohexameric interface [polypeptide binding]; other site 146891001526 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 146891001527 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 146891001528 homodimer interface [polypeptide binding]; other site 146891001529 Walker A motif; other site 146891001530 ATP binding site [chemical binding]; other site 146891001531 hydroxycobalamin binding site [chemical binding]; other site 146891001532 Walker B motif; other site 146891001533 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 146891001534 DNA binding site [nucleotide binding] 146891001535 Int/Topo IB signature motif; other site 146891001536 active site 146891001537 catalytic residues [active] 146891001538 ferrochelatase; Reviewed; Region: hemH; PRK00035 146891001539 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 146891001540 C-terminal domain interface [polypeptide binding]; other site 146891001541 active site 146891001542 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 146891001543 active site 146891001544 N-terminal domain interface [polypeptide binding]; other site 146891001545 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 146891001546 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 146891001547 PYR/PP interface [polypeptide binding]; other site 146891001548 dimer interface [polypeptide binding]; other site 146891001549 TPP binding site [chemical binding]; other site 146891001550 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 146891001551 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 146891001552 TPP-binding site [chemical binding]; other site 146891001553 dimer interface [polypeptide binding]; other site 146891001554 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 146891001555 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 146891001556 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 146891001557 RNA binding site [nucleotide binding]; other site 146891001558 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 146891001559 RNA binding site [nucleotide binding]; other site 146891001560 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 146891001561 RNA binding site [nucleotide binding]; other site 146891001562 Creatinine amidohydrolase; Region: Creatininase; cl00618 146891001563 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 146891001564 dinuclear metal binding motif [ion binding]; other site 146891001565 acyl-ACP reductase; Provisional; Region: PRK14982 146891001566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001567 NAD(P) binding pocket [chemical binding]; other site 146891001568 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 146891001569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 146891001570 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 146891001571 classical (c) SDRs; Region: SDR_c; cd05233 146891001572 NAD(P) binding site [chemical binding]; other site 146891001573 active site 146891001574 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891001575 GTP cyclohydrolase I; Provisional; Region: PLN03044 146891001576 active site 146891001577 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 146891001578 active site 146891001579 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 146891001580 active site 146891001581 putative substrate binding region [chemical binding]; other site 146891001582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 146891001583 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 146891001584 Photosystem I protein M (PsaM); Region: PsaM; cl15374 146891001585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001586 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 146891001587 NAD(P) binding site [chemical binding]; other site 146891001588 active site 146891001589 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 146891001590 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 146891001591 P-loop; other site 146891001592 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 146891001593 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 146891001594 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 146891001595 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 146891001596 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 146891001597 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 146891001598 putative hexamer interface [polypeptide binding]; other site 146891001599 putative hexagonal pore; other site 146891001600 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 146891001601 putative hexamer interface [polypeptide binding]; other site 146891001602 putative hexagonal pore; other site 146891001603 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 146891001604 active site 146891001605 dimerization interface [polypeptide binding]; other site 146891001606 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 146891001607 Hexamer interface [polypeptide binding]; other site 146891001608 Hexagonal pore residue; other site 146891001609 Hexagonal pore; other site 146891001610 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 146891001611 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 146891001612 dimer interface [polypeptide binding]; other site 146891001613 catalytic residue [active] 146891001614 metal binding site [ion binding]; metal-binding site 146891001615 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 146891001616 multimerization interface [polypeptide binding]; other site 146891001617 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 146891001618 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 146891001619 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 146891001620 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 146891001621 Hexamer/Pentamer interface [polypeptide binding]; other site 146891001622 central pore; other site 146891001623 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 146891001624 Hexamer/Pentamer interface [polypeptide binding]; other site 146891001625 central pore; other site 146891001626 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 146891001627 DCoH dimer interaction site [polypeptide binding]; other site 146891001628 aromatic arch; other site 146891001629 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 146891001630 DCoH tetramer interaction site [polypeptide binding]; other site 146891001631 substrate binding site [chemical binding]; other site 146891001632 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 146891001633 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 146891001634 homotrimer interaction site [polypeptide binding]; other site 146891001635 putative active site [active] 146891001636 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891001637 ATP phosphoribosyltransferase; Region: HisG; cl15266 146891001638 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891001639 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 146891001640 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 146891001641 Walker A/P-loop; other site 146891001642 ATP binding site [chemical binding]; other site 146891001643 Q-loop/lid; other site 146891001644 ABC transporter signature motif; other site 146891001645 Walker B; other site 146891001646 D-loop; other site 146891001647 H-loop/switch region; other site 146891001648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891001649 Coenzyme A binding pocket [chemical binding]; other site 146891001650 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 146891001651 Probable Catalytic site; other site 146891001652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891001653 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 146891001654 hypothetical protein; Validated; Region: PRK06672 146891001655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891001656 Walker A motif; other site 146891001657 ATP binding site [chemical binding]; other site 146891001658 Walker B motif; other site 146891001659 arginine finger; other site 146891001660 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 146891001661 DnaA box-binding interface [nucleotide binding]; other site 146891001662 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 146891001663 glutathione S-transferase DHAR1; Region: PLN02378 146891001664 C-terminal domain interface [polypeptide binding]; other site 146891001665 GSH binding site (G-site) [chemical binding]; other site 146891001666 dimer interface [polypeptide binding]; other site 146891001667 glutathione reductase; Validated; Region: PRK06116 146891001668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001669 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 146891001670 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 146891001671 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 146891001672 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 146891001673 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 146891001674 active site 146891001675 substrate binding pocket [chemical binding]; other site 146891001676 dimer interface [polypeptide binding]; other site 146891001677 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 146891001678 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 146891001679 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 146891001680 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 146891001681 substrate binding site [chemical binding]; other site 146891001682 active site 146891001683 catalytic residues [active] 146891001684 heterodimer interface [polypeptide binding]; other site 146891001685 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 146891001686 YCII-related domain; Region: YCII; cl00999 146891001687 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 146891001688 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891001689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891001690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891001691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891001692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891001693 DNA binding residues [nucleotide binding] 146891001694 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 146891001695 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 146891001696 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 146891001697 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891001698 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 146891001699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891001700 Walker A motif; other site 146891001701 ATP binding site [chemical binding]; other site 146891001702 Walker B motif; other site 146891001703 arginine finger; other site 146891001704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891001705 Walker A motif; other site 146891001706 ATP binding site [chemical binding]; other site 146891001707 Walker B motif; other site 146891001708 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 146891001709 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 146891001710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001711 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891001712 NAD(P) binding site [chemical binding]; other site 146891001713 active site 146891001714 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 146891001715 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 146891001716 substrate binding site [chemical binding]; other site 146891001717 active site 146891001718 glycogen branching enzyme; Provisional; Region: PRK05402 146891001719 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 146891001720 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 146891001721 active site 146891001722 catalytic site [active] 146891001723 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 146891001724 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 146891001725 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 146891001726 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 146891001727 Protein of function (DUF2518); Region: DUF2518; pfam10726 146891001728 Family of unknown function (DUF490); Region: DUF490; pfam04357 146891001729 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 146891001730 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 146891001731 putative catalytic cysteine [active] 146891001732 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891001733 active site 146891001734 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 146891001735 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 146891001736 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 146891001737 active site 146891001738 Zn binding site [ion binding]; other site 146891001739 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 146891001740 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 146891001741 homoserine kinase; Provisional; Region: PRK01212 146891001742 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 146891001743 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 146891001744 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 146891001745 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 146891001746 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 146891001747 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 146891001748 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 146891001749 active site 146891001750 dimer interface [polypeptide binding]; other site 146891001751 motif 1; other site 146891001752 motif 2; other site 146891001753 motif 3; other site 146891001754 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 146891001755 anticodon binding site; other site 146891001756 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 146891001757 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 146891001758 active site 146891001759 HIGH motif; other site 146891001760 dimer interface [polypeptide binding]; other site 146891001761 KMSKS motif; other site 146891001762 Domain of unknown function (DUF697); Region: DUF697; cl12064 146891001763 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 146891001764 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 146891001765 metal binding site [ion binding]; metal-binding site 146891001766 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 146891001767 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 146891001768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 146891001769 ABC-ATPase subunit interface; other site 146891001770 dimer interface [polypeptide binding]; other site 146891001771 putative PBP binding regions; other site 146891001772 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 146891001773 Protein of unknown function (DUF760); Region: DUF760; pfam05542 146891001774 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 146891001775 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 146891001776 Catalytic site [active] 146891001777 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 146891001778 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 146891001779 dimer interface [polypeptide binding]; other site 146891001780 tetramer interface [polypeptide binding]; other site 146891001781 PYR/PP interface [polypeptide binding]; other site 146891001782 TPP binding site [chemical binding]; other site 146891001783 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 146891001784 TPP-binding site; other site 146891001785 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 146891001786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 146891001787 substrate binding site [chemical binding]; other site 146891001788 oxyanion hole (OAH) forming residues; other site 146891001789 trimer interface [polypeptide binding]; other site 146891001790 glycogen synthase; Provisional; Region: glgA; PRK00654 146891001791 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 146891001792 ADP-binding pocket [chemical binding]; other site 146891001793 homodimer interface [polypeptide binding]; other site 146891001794 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 146891001795 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 146891001796 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 146891001797 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 146891001798 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 146891001799 Substrate binding site; other site 146891001800 Mg++ binding site; other site 146891001801 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 146891001802 active site 146891001803 substrate binding site [chemical binding]; other site 146891001804 CoA binding site [chemical binding]; other site 146891001805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891001806 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 146891001807 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 146891001808 hinge; other site 146891001809 active site 146891001810 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 146891001811 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 146891001812 Predicted amidohydrolase [General function prediction only]; Region: COG0388 146891001813 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 146891001814 putative active site [active] 146891001815 catalytic triad [active] 146891001816 dimer interface [polypeptide binding]; other site 146891001817 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 146891001818 active site 146891001819 metal binding site [ion binding]; metal-binding site 146891001820 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 146891001821 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 146891001822 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 146891001823 substrate binding pocket [chemical binding]; other site 146891001824 chain length determination region; other site 146891001825 substrate-Mg2+ binding site; other site 146891001826 catalytic residues [active] 146891001827 aspartate-rich region 1; other site 146891001828 active site lid residues [active] 146891001829 aspartate-rich region 2; other site 146891001830 acetyl-CoA synthetase; Provisional; Region: PRK00174 146891001831 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 146891001832 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 146891001833 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 146891001834 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 146891001835 active site 146891001836 substrate binding site [chemical binding]; other site 146891001837 catalytic site [active] 146891001838 GLTT repeat (6 copies); Region: GLTT; pfam01744 146891001839 GLTT repeat (6 copies); Region: GLTT; pfam01744 146891001840 Protein of unknown function; Region: DUF3721; pfam12518 146891001841 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 146891001842 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 146891001843 dimer interface [polypeptide binding]; other site 146891001844 motif 1; other site 146891001845 active site 146891001846 motif 2; other site 146891001847 motif 3; other site 146891001848 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 146891001849 anticodon binding site; other site 146891001850 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 146891001851 Photosystem II protein; Region: PSII; cl08223 146891001852 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 146891001853 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891001854 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 146891001855 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 146891001856 putative N-terminal domain interface [polypeptide binding]; other site 146891001857 putative dimer interface [polypeptide binding]; other site 146891001858 putative substrate binding pocket (H-site) [chemical binding]; other site 146891001859 T5orf172 domain; Region: T5orf172; cl11176 146891001860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001861 acetoin reductases; Region: 23BDH; TIGR02415 146891001862 NAD(P) binding site [chemical binding]; other site 146891001863 active site 146891001864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001865 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 146891001866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891001867 NAD(P) binding site [chemical binding]; other site 146891001868 active site 146891001869 Mechanosensitive ion channel; Region: MS_channel; pfam00924 146891001870 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 146891001871 Isochorismatase family; Region: Isochorismatase; pfam00857 146891001872 catalytic triad [active] 146891001873 dimer interface [polypeptide binding]; other site 146891001874 conserved cis-peptide bond; other site 146891001875 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 146891001876 metal binding site 2 [ion binding]; metal-binding site 146891001877 putative DNA binding helix; other site 146891001878 metal binding site 1 [ion binding]; metal-binding site 146891001879 dimer interface [polypeptide binding]; other site 146891001880 structural Zn2+ binding site [ion binding]; other site 146891001881 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 146891001882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891001883 FeS/SAM binding site; other site 146891001884 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 146891001885 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 146891001886 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 146891001887 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 146891001888 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 146891001889 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 146891001890 homodimer interface [polypeptide binding]; other site 146891001891 substrate-cofactor binding pocket; other site 146891001892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001893 catalytic residue [active] 146891001894 Homoserine O-succinyltransferase; Region: HTS; pfam04204 146891001895 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 146891001896 conserved cys residue [active] 146891001897 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 146891001898 Permease family; Region: Xan_ur_permease; cl00967 146891001899 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 146891001900 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 146891001901 FAD binding domain; Region: FAD_binding_4; pfam01565 146891001902 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 146891001903 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 146891001904 putative active site [active] 146891001905 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 146891001906 putative active site [active] 146891001907 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 146891001908 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 146891001909 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 146891001910 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891001911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891001912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 146891001913 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 146891001914 dimer interface [polypeptide binding]; other site 146891001915 active site 146891001916 metal binding site [ion binding]; metal-binding site 146891001917 glutathione binding site [chemical binding]; other site 146891001918 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 146891001919 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 146891001920 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 146891001921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891001922 S-adenosylmethionine binding site [chemical binding]; other site 146891001923 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 146891001924 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 146891001925 G1 box; other site 146891001926 putative GEF interaction site [polypeptide binding]; other site 146891001927 GTP/Mg2+ binding site [chemical binding]; other site 146891001928 Switch I region; other site 146891001929 G2 box; other site 146891001930 G3 box; other site 146891001931 Switch II region; other site 146891001932 G4 box; other site 146891001933 G5 box; other site 146891001934 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 146891001935 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 146891001936 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 146891001937 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 146891001938 dimerization interface [polypeptide binding]; other site 146891001939 domain crossover interface; other site 146891001940 redox-dependent activation switch; other site 146891001941 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 146891001942 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 146891001943 Walker A/P-loop; other site 146891001944 ATP binding site [chemical binding]; other site 146891001945 Q-loop/lid; other site 146891001946 ABC transporter signature motif; other site 146891001947 Walker B; other site 146891001948 D-loop; other site 146891001949 H-loop/switch region; other site 146891001950 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 146891001951 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 146891001952 RNA methyltransferase, RsmE family; Region: TIGR00046 146891001953 Integral membrane protein DUF92; Region: DUF92; cl00793 146891001954 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 146891001955 active site 146891001956 catalytic triad [active] 146891001957 oxyanion hole [active] 146891001958 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 146891001959 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 146891001960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891001961 Walker A/P-loop; other site 146891001962 ATP binding site [chemical binding]; other site 146891001963 Q-loop/lid; other site 146891001964 ABC transporter signature motif; other site 146891001965 Walker B; other site 146891001966 D-loop; other site 146891001967 H-loop/switch region; other site 146891001968 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 146891001969 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 146891001970 aspartate aminotransferase; Provisional; Region: PRK05764 146891001971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891001972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891001973 homodimer interface [polypeptide binding]; other site 146891001974 catalytic residue [active] 146891001975 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 146891001976 active site 146891001977 Fe-S cluster binding site [ion binding]; other site 146891001978 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 146891001979 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 146891001980 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 146891001981 C-terminal peptidase (prc); Region: prc; TIGR00225 146891001982 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 146891001983 protein binding site [polypeptide binding]; other site 146891001984 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 146891001985 Catalytic dyad [active] 146891001986 Quinolinate synthetase A protein; Region: NadA; cl00420 146891001987 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 146891001988 active site 146891001989 metal binding site [ion binding]; metal-binding site 146891001990 Domain of unknown function (DUF477); Region: DUF477; cl01535 146891001991 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 146891001992 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 146891001993 active site 146891001994 dimer interface [polypeptide binding]; other site 146891001995 metal binding site [ion binding]; metal-binding site 146891001996 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 146891001997 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891001998 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891001999 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 146891002000 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 146891002001 nucleotide binding pocket [chemical binding]; other site 146891002002 K-X-D-G motif; other site 146891002003 catalytic site [active] 146891002004 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891002005 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 146891002006 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 146891002007 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 146891002008 NADP binding site [chemical binding]; other site 146891002009 homodimer interface [polypeptide binding]; other site 146891002010 active site 146891002011 chaperone protein DnaJ; Provisional; Region: PRK14276 146891002012 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891002013 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 146891002014 Ion channel; Region: Ion_trans_2; cl11596 146891002015 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 146891002016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002017 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 146891002018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 146891002019 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 146891002020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891002021 dimer interface [polypeptide binding]; other site 146891002022 conserved gate region; other site 146891002023 putative PBP binding loops; other site 146891002024 ABC-ATPase subunit interface; other site 146891002025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 146891002026 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 146891002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891002028 dimer interface [polypeptide binding]; other site 146891002029 conserved gate region; other site 146891002030 putative PBP binding loops; other site 146891002031 ABC-ATPase subunit interface; other site 146891002032 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 146891002033 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 146891002034 Walker A/P-loop; other site 146891002035 ATP binding site [chemical binding]; other site 146891002036 Q-loop/lid; other site 146891002037 ABC transporter signature motif; other site 146891002038 Walker B; other site 146891002039 D-loop; other site 146891002040 H-loop/switch region; other site 146891002041 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 146891002042 putative active site [active] 146891002043 putative metal binding site [ion binding]; other site 146891002044 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 146891002045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891002046 ATP binding site [chemical binding]; other site 146891002047 putative Mg++ binding site [ion binding]; other site 146891002048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891002049 nucleotide binding region [chemical binding]; other site 146891002050 ATP-binding site [chemical binding]; other site 146891002051 DEAD/H associated; Region: DEAD_assoc; pfam08494 146891002052 ATP-dependent DNA ligase; Validated; Region: PRK09247 146891002053 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 146891002054 active site 146891002055 DNA binding site [nucleotide binding] 146891002056 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 146891002057 DNA binding site [nucleotide binding] 146891002058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891002059 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 146891002060 translation initiation factor IF-2; Validated; Region: infB; PRK05306 146891002061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 146891002062 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 146891002063 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 146891002064 PetN; Region: PetN; cl15376 146891002065 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 146891002066 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891002067 oligomer interface [polypeptide binding]; other site 146891002068 active site residues [active] 146891002069 cell division protein; Validated; Region: ftsH; CHL00176 146891002070 FtsH Extracellular; Region: FtsH_ext; pfam06480 146891002071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891002072 Walker A motif; other site 146891002073 ATP binding site [chemical binding]; other site 146891002074 Walker B motif; other site 146891002075 arginine finger; other site 146891002076 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891002077 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 146891002078 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 146891002079 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 146891002080 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 146891002081 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 146891002082 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 146891002083 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 146891002084 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 146891002085 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 146891002086 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 146891002087 DevC protein; Region: devC; TIGR01185 146891002088 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 146891002089 FtsX-like permease family; Region: FtsX; pfam02687 146891002090 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 146891002091 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 146891002092 Walker A/P-loop; other site 146891002093 ATP binding site [chemical binding]; other site 146891002094 Q-loop/lid; other site 146891002095 ABC transporter signature motif; other site 146891002096 Walker B; other site 146891002097 D-loop; other site 146891002098 H-loop/switch region; other site 146891002099 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 146891002100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002101 active site 146891002102 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 146891002103 rRNA interaction site [nucleotide binding]; other site 146891002104 S8 interaction site; other site 146891002105 putative laminin-1 binding site; other site 146891002106 elongation factor Ts; Reviewed; Region: tsf; PRK12332 146891002107 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 146891002108 Elongation factor TS; Region: EF_TS; pfam00889 146891002109 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 146891002110 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 146891002111 generic binding surface II; other site 146891002112 ssDNA binding site; other site 146891002113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891002114 ATP binding site [chemical binding]; other site 146891002115 putative Mg++ binding site [ion binding]; other site 146891002116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891002117 nucleotide binding region [chemical binding]; other site 146891002118 ATP-binding site [chemical binding]; other site 146891002119 sulfite reductase subunit beta; Provisional; Region: PRK13504 146891002120 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 146891002121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 146891002122 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 146891002123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002124 geranylgeranyl reductase; Region: ChlP; TIGR02028 146891002125 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 146891002126 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 146891002127 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 146891002128 G1 box; other site 146891002129 putative GEF interaction site [polypeptide binding]; other site 146891002130 GTP/Mg2+ binding site [chemical binding]; other site 146891002131 Switch I region; other site 146891002132 G2 box; other site 146891002133 G3 box; other site 146891002134 Switch II region; other site 146891002135 G4 box; other site 146891002136 G5 box; other site 146891002137 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 146891002138 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 146891002139 Domain of unknown function (DUF309); Region: DUF309; cl00667 146891002140 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 146891002141 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 146891002142 Walker A/P-loop; other site 146891002143 ATP binding site [chemical binding]; other site 146891002144 Q-loop/lid; other site 146891002145 ABC transporter signature motif; other site 146891002146 Walker B; other site 146891002147 D-loop; other site 146891002148 H-loop/switch region; other site 146891002149 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 146891002150 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 146891002151 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 146891002152 substrate binding site [chemical binding]; other site 146891002153 hexamer interface [polypeptide binding]; other site 146891002154 metal binding site [ion binding]; metal-binding site 146891002155 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 146891002156 putative active site [active] 146891002157 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 146891002158 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 146891002159 tRNA; other site 146891002160 putative tRNA binding site [nucleotide binding]; other site 146891002161 putative NADP binding site [chemical binding]; other site 146891002162 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 146891002163 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 146891002164 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 146891002165 ligand binding site; other site 146891002166 oligomer interface; other site 146891002167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002168 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 146891002169 dimer interface [polypeptide binding]; other site 146891002170 N-terminal domain interface [polypeptide binding]; other site 146891002171 sulfate 1 binding site; other site 146891002172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002173 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 146891002174 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 146891002175 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 146891002176 putative active site [active] 146891002177 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 146891002178 Dehydratase family; Region: ILVD_EDD; cl00340 146891002179 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891002180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002182 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 146891002183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002184 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 146891002185 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 146891002186 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 146891002187 putative active site [active] 146891002188 catalytic triad [active] 146891002189 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 146891002190 hypothetical protein; Provisional; Region: PRK08185 146891002191 intersubunit interface [polypeptide binding]; other site 146891002192 active site 146891002193 zinc binding site [ion binding]; other site 146891002194 Na+ binding site [ion binding]; other site 146891002195 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 146891002196 active site 146891002197 intersubunit interface [polypeptide binding]; other site 146891002198 catalytic residue [active] 146891002199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891002200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002201 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 146891002202 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 146891002203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 146891002204 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 146891002205 active site 146891002206 tartrate dehydrogenase; Provisional; Region: PRK08194 146891002207 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 146891002208 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 146891002209 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 146891002210 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 146891002211 trimer interface [polypeptide binding]; other site 146891002212 active site 146891002213 UDP-GlcNAc binding site [chemical binding]; other site 146891002214 lipid binding site [chemical binding]; lipid-binding site 146891002215 gamma-glutamyl kinase; Provisional; Region: PRK05429 146891002216 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 146891002217 nucleotide binding site [chemical binding]; other site 146891002218 homotetrameric interface [polypeptide binding]; other site 146891002219 putative phosphate binding site [ion binding]; other site 146891002220 putative allosteric binding site; other site 146891002221 PUA domain; Region: PUA; cl00607 146891002222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891002223 active site 146891002224 motif I; other site 146891002225 motif II; other site 146891002226 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 146891002227 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 146891002228 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 146891002229 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 146891002230 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 146891002231 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 146891002232 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 146891002233 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 146891002234 catalytic residues [active] 146891002235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891002236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002237 NAD(P) binding site [chemical binding]; other site 146891002238 active site 146891002239 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 146891002240 Domain of unknown function (DUF296); Region: DUF296; cl00720 146891002241 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 146891002242 GSH binding site [chemical binding]; other site 146891002243 catalytic residues [active] 146891002244 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 146891002245 NAD(P) binding site [chemical binding]; other site 146891002246 putative active site [active] 146891002247 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 146891002248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 146891002249 minor groove reading motif; other site 146891002250 helix-hairpin-helix signature motif; other site 146891002251 substrate binding pocket [chemical binding]; other site 146891002252 active site 146891002253 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 146891002254 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 146891002255 Walker A/P-loop; other site 146891002256 ATP binding site [chemical binding]; other site 146891002257 Q-loop/lid; other site 146891002258 ABC transporter signature motif; other site 146891002259 Walker B; other site 146891002260 D-loop; other site 146891002261 H-loop/switch region; other site 146891002262 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 146891002263 Ferritin-like domain; Region: Ferritin; pfam00210 146891002264 ferroxidase diiron center [ion binding]; other site 146891002265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 146891002266 Helix-turn-helix domains; Region: HTH; cl00088 146891002267 putative switch regulator; other site 146891002268 non-specific DNA interactions [nucleotide binding]; other site 146891002269 DNA binding site [nucleotide binding] 146891002270 sequence specific DNA binding site [nucleotide binding]; other site 146891002271 putative cAMP binding site [chemical binding]; other site 146891002272 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 146891002273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002274 Walker A/P-loop; other site 146891002275 ATP binding site [chemical binding]; other site 146891002276 Q-loop/lid; other site 146891002277 ABC transporter signature motif; other site 146891002278 Walker B; other site 146891002279 D-loop; other site 146891002280 H-loop/switch region; other site 146891002281 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 146891002282 [2Fe-2S] cluster binding site [ion binding]; other site 146891002283 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 146891002284 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 146891002285 Walker A/P-loop; other site 146891002286 ATP binding site [chemical binding]; other site 146891002287 Q-loop/lid; other site 146891002288 ABC transporter signature motif; other site 146891002289 Walker B; other site 146891002290 D-loop; other site 146891002291 H-loop/switch region; other site 146891002292 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 146891002293 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 146891002294 Walker A/P-loop; other site 146891002295 ATP binding site [chemical binding]; other site 146891002296 Q-loop/lid; other site 146891002297 ABC transporter signature motif; other site 146891002298 Walker B; other site 146891002299 D-loop; other site 146891002300 H-loop/switch region; other site 146891002301 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 146891002302 TM-ABC transporter signature motif; other site 146891002303 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 146891002304 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 146891002305 TM-ABC transporter signature motif; other site 146891002306 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 146891002307 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 146891002308 putative ligand binding site [chemical binding]; other site 146891002309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002310 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 146891002311 UreF; Region: UreF; pfam01730 146891002312 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 146891002313 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 146891002314 dimer interface [polypeptide binding]; other site 146891002315 catalytic residues [active] 146891002316 UreD urease accessory protein; Region: UreD; cl00530 146891002317 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 146891002318 alpha-gamma subunit interface [polypeptide binding]; other site 146891002319 beta-gamma subunit interface [polypeptide binding]; other site 146891002320 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 146891002321 gamma-beta subunit interface [polypeptide binding]; other site 146891002322 alpha-beta subunit interface [polypeptide binding]; other site 146891002323 urease subunit alpha; Reviewed; Region: ureC; PRK13207 146891002324 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 146891002325 subunit interactions [polypeptide binding]; other site 146891002326 active site 146891002327 flap region; other site 146891002328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891002330 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 146891002331 active site 146891002332 catalytic site [active] 146891002333 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 146891002334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891002335 active site 146891002336 motif I; other site 146891002337 motif II; other site 146891002338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002339 active site 146891002340 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 146891002341 Bacitracin resistance protein BacA; Region: BacA; cl00858 146891002342 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 146891002343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891002344 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 146891002345 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002346 Walker A/P-loop; other site 146891002347 ATP binding site [chemical binding]; other site 146891002348 Q-loop/lid; other site 146891002349 ABC transporter signature motif; other site 146891002350 Walker B; other site 146891002351 D-loop; other site 146891002352 H-loop/switch region; other site 146891002353 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 146891002354 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 146891002355 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 146891002356 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 146891002357 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 146891002358 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 146891002359 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 146891002360 catalytic site [active] 146891002361 subunit interface [polypeptide binding]; other site 146891002362 similar to hypothetical protein 146891002363 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 146891002364 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 146891002365 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 146891002366 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 146891002367 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 146891002368 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 146891002369 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 146891002370 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 146891002371 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 146891002372 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 146891002373 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 146891002374 generic binding surface I; other site 146891002375 generic binding surface II; other site 146891002376 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 146891002377 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 146891002378 16S/18S rRNA binding site [nucleotide binding]; other site 146891002379 S13e-L30e interaction site [polypeptide binding]; other site 146891002380 25S rRNA binding site [nucleotide binding]; other site 146891002381 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 146891002382 RuvA N terminal domain; Region: RuvA_N; pfam01330 146891002383 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 146891002384 EamA-like transporter family; Region: EamA; cl01037 146891002385 DNA primase; Validated; Region: dnaG; PRK05667 146891002386 CHC2 zinc finger; Region: zf-CHC2; cl15369 146891002387 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 146891002388 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 146891002389 active site 146891002390 metal binding site [ion binding]; metal-binding site 146891002391 interdomain interaction site; other site 146891002392 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 146891002393 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 146891002394 active site 146891002395 DNA binding site [nucleotide binding] 146891002396 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 146891002397 Catalytic site [active] 146891002398 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 146891002399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891002400 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 146891002401 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 146891002402 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 146891002403 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 146891002404 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 146891002405 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 146891002406 alpha subunit interface [polypeptide binding]; other site 146891002407 TPP binding site [chemical binding]; other site 146891002408 heterodimer interface [polypeptide binding]; other site 146891002409 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891002410 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 146891002411 Protein export membrane protein; Region: SecD_SecF; cl14618 146891002412 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 146891002413 Protein export membrane protein; Region: SecD_SecF; cl14618 146891002414 Domain of unknown function DUF20; Region: UPF0118; cl00465 146891002415 Psb28 protein; Region: Psb28; cl04326 146891002416 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 146891002417 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 146891002418 active site residue [active] 146891002419 GUN4-like; Region: GUN4; pfam05419 146891002420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 146891002421 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 146891002422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891002423 S-adenosylmethionine binding site [chemical binding]; other site 146891002424 glutamine synthetase, type I; Region: GlnA; TIGR00653 146891002425 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 146891002426 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 146891002427 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 146891002428 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 146891002429 homodimer interface [polypeptide binding]; other site 146891002430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891002431 catalytic residue [active] 146891002432 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 146891002433 nucleoside/Zn binding site; other site 146891002434 dimer interface [polypeptide binding]; other site 146891002435 catalytic motif [active] 146891002436 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 146891002437 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891002438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891002439 catalytic residue [active] 146891002440 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 146891002441 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 146891002442 G1 box; other site 146891002443 GTP/Mg2+ binding site [chemical binding]; other site 146891002444 Switch I region; other site 146891002445 G2 box; other site 146891002446 Switch II region; other site 146891002447 G3 box; other site 146891002448 Domain of unknown function (DUF697); Region: DUF697; cl12064 146891002449 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 146891002450 lipoprotein signal peptidase; Provisional; Region: PRK14787 146891002451 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 146891002452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 146891002453 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 146891002454 FtsX-like permease family; Region: FtsX; pfam02687 146891002455 pyruvate kinase; Provisional; Region: PRK06354 146891002456 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 146891002457 domain interfaces; other site 146891002458 active site 146891002459 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 146891002460 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 146891002461 YGGT family; Region: YGGT; cl00508 146891002462 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 146891002463 threonine dehydratase; Reviewed; Region: PRK09224 146891002464 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 146891002465 tetramer interface [polypeptide binding]; other site 146891002466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891002467 catalytic residue [active] 146891002468 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 146891002469 putative Ile/Val binding site [chemical binding]; other site 146891002470 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 146891002471 putative Ile/Val binding site [chemical binding]; other site 146891002472 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 146891002473 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 146891002474 TPP-binding site; other site 146891002475 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 146891002476 PYR/PP interface [polypeptide binding]; other site 146891002477 dimer interface [polypeptide binding]; other site 146891002478 TPP binding site [chemical binding]; other site 146891002479 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891002480 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 146891002481 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 146891002482 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 146891002483 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 146891002484 catalytic triad [active] 146891002485 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 146891002486 heat shock protein 90; Provisional; Region: PRK05218 146891002487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891002488 ATP binding site [chemical binding]; other site 146891002489 Mg2+ binding site [ion binding]; other site 146891002490 G-X-G motif; other site 146891002491 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 146891002492 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 146891002493 dimer interface [polypeptide binding]; other site 146891002494 motif 1; other site 146891002495 active site 146891002496 motif 2; other site 146891002497 motif 3; other site 146891002498 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 146891002499 active site 146891002500 dimerization interface [polypeptide binding]; other site 146891002501 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891002502 catalytic loop [active] 146891002503 iron binding site [ion binding]; other site 146891002504 molecular chaperone DnaK; Provisional; Region: PRK13410 146891002505 chaperone protein DnaJ; Provisional; Region: PRK14299 146891002506 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891002507 HSP70 interaction site [polypeptide binding]; other site 146891002508 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 146891002509 substrate binding site [polypeptide binding]; other site 146891002510 dimer interface [polypeptide binding]; other site 146891002511 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 146891002512 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 146891002513 active site 146891002514 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 146891002515 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 146891002516 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 146891002517 dimerization interface [polypeptide binding]; other site 146891002518 active site 146891002519 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 146891002520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002521 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 146891002522 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 146891002523 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 146891002524 active site 146891002525 substrate binding site [chemical binding]; other site 146891002526 cosubstrate binding site; other site 146891002527 catalytic site [active] 146891002528 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 146891002529 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 146891002530 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 146891002531 dimer interface [polypeptide binding]; other site 146891002532 active site 146891002533 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 146891002534 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 146891002535 HIGH motif; other site 146891002536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891002537 active site 146891002538 KMSKS motif; other site 146891002539 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 146891002540 tRNA binding surface [nucleotide binding]; other site 146891002541 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 146891002542 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 146891002543 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 146891002544 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 146891002545 Aminotransferase class-V; Region: Aminotran_5; pfam00266 146891002546 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891002547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891002548 catalytic residue [active] 146891002549 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 146891002550 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 146891002551 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 146891002552 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 146891002553 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 146891002554 active site 146891002555 (T/H)XGH motif; other site 146891002556 Flavin Reductases; Region: FlaRed; cl00801 146891002557 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 146891002558 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 146891002559 GIY-YIG motif/motif A; other site 146891002560 active site 146891002561 catalytic site [active] 146891002562 putative DNA binding site [nucleotide binding]; other site 146891002563 metal binding site [ion binding]; metal-binding site 146891002564 UvrB/uvrC motif; Region: UVR; pfam02151 146891002565 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 146891002566 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 146891002567 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 146891002568 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 146891002569 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 146891002570 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002571 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002572 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 146891002573 homodimer interface [polypeptide binding]; other site 146891002574 substrate-cofactor binding pocket; other site 146891002575 Aminotransferase class IV; Region: Aminotran_4; pfam01063 146891002576 catalytic residue [active] 146891002577 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 146891002578 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 146891002579 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 146891002580 substrate binding pocket [chemical binding]; other site 146891002581 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 146891002582 B12 binding site [chemical binding]; other site 146891002583 cobalt ligand [ion binding]; other site 146891002584 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 146891002585 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 146891002586 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 146891002587 ATP adenylyltransferase; Region: ATP_transf; pfam09830 146891002588 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 146891002589 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891002590 HSP70 interaction site [polypeptide binding]; other site 146891002591 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 146891002592 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 146891002593 putative tRNA-binding site [nucleotide binding]; other site 146891002594 B3/4 domain; Region: B3_4; cl11458 146891002595 tRNA synthetase B5 domain; Region: B5; cl08394 146891002596 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 146891002597 dimer interface [polypeptide binding]; other site 146891002598 motif 1; other site 146891002599 motif 3; other site 146891002600 motif 2; other site 146891002601 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 146891002602 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 146891002603 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 146891002604 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 146891002605 RNB domain; Region: RNB; pfam00773 146891002606 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 146891002607 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 146891002608 active site 146891002609 HIGH motif; other site 146891002610 KMSKS motif; other site 146891002611 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 146891002612 tRNA binding surface [nucleotide binding]; other site 146891002613 anticodon binding site; other site 146891002614 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 146891002615 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 146891002616 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 146891002617 homotrimer interface [polypeptide binding]; other site 146891002618 Walker A motif; other site 146891002619 GTP binding site [chemical binding]; other site 146891002620 Walker B motif; other site 146891002621 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 146891002622 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 146891002623 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891002624 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 146891002625 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 146891002626 dimer interface [polypeptide binding]; other site 146891002627 decamer (pentamer of dimers) interface [polypeptide binding]; other site 146891002628 catalytic triad [active] 146891002629 peroxidatic and resolving cysteines [active] 146891002630 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 146891002631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891002632 Walker A motif; other site 146891002633 ATP binding site [chemical binding]; other site 146891002634 Walker B motif; other site 146891002635 arginine finger; other site 146891002636 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891002637 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 146891002638 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 146891002639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891002640 motif II; other site 146891002641 Flagellin N-methylase; Region: FliB; cl00497 146891002642 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 146891002643 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 146891002644 ribonuclease R; Region: RNase_R; TIGR02063 146891002645 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 146891002646 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 146891002647 RNB domain; Region: RNB; pfam00773 146891002648 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 146891002649 RNA binding site [nucleotide binding]; other site 146891002650 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 146891002651 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 146891002652 diiron binding motif [ion binding]; other site 146891002653 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 146891002654 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 146891002655 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 146891002656 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 146891002657 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 146891002658 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 146891002659 putative active site [active] 146891002660 substrate binding site [chemical binding]; other site 146891002661 putative cosubstrate binding site; other site 146891002662 catalytic site [active] 146891002663 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 146891002664 substrate binding site [chemical binding]; other site 146891002665 Integral membrane protein TerC family; Region: TerC; cl10468 146891002666 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 146891002667 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 146891002668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891002669 ATP binding site [chemical binding]; other site 146891002670 putative Mg++ binding site [ion binding]; other site 146891002671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891002672 nucleotide binding region [chemical binding]; other site 146891002673 ATP-binding site [chemical binding]; other site 146891002674 TRCF domain; Region: TRCF; cl04088 146891002675 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 146891002676 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 146891002677 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 146891002678 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 146891002679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002680 dihydrodipicolinate reductase; Provisional; Region: PRK00048 146891002681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002682 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 146891002683 magnesium chelatase subunit H; Provisional; Region: PRK12493 146891002684 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 146891002685 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002686 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 146891002687 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 146891002688 dihydropteroate synthase; Region: DHPS; TIGR01496 146891002689 substrate binding pocket [chemical binding]; other site 146891002690 dimer interface [polypeptide binding]; other site 146891002691 inhibitor binding site; inhibition site 146891002692 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 146891002693 substrate binding site [chemical binding]; other site 146891002694 dimer interface [polypeptide binding]; other site 146891002695 catalytic triad [active] 146891002696 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891002697 RNA binding surface [nucleotide binding]; other site 146891002698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891002699 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 146891002700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002701 Walker A/P-loop; other site 146891002702 ATP binding site [chemical binding]; other site 146891002703 Q-loop/lid; other site 146891002704 ABC transporter signature motif; other site 146891002705 Walker B; other site 146891002706 D-loop; other site 146891002707 H-loop/switch region; other site 146891002708 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 146891002709 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 146891002710 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891002711 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 146891002712 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891002713 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 146891002714 IMP binding site; other site 146891002715 dimer interface [polypeptide binding]; other site 146891002716 interdomain contacts; other site 146891002717 partial ornithine binding site; other site 146891002718 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 146891002719 Domain of unknown function DUF143; Region: DUF143; cl00519 146891002720 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 146891002721 L-asparaginase II; Region: Asparaginase_II; cl01842 146891002722 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 146891002723 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 146891002724 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 146891002725 Walker A/P-loop; other site 146891002726 ATP binding site [chemical binding]; other site 146891002727 Q-loop/lid; other site 146891002728 ABC transporter signature motif; other site 146891002729 Walker B; other site 146891002730 D-loop; other site 146891002731 H-loop/switch region; other site 146891002732 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 146891002733 Protein of unknown function (DUF990); Region: DUF990; cl01496 146891002734 Protein of unknown function (DUF990); Region: DUF990; cl01496 146891002735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 146891002736 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 146891002737 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891002738 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 146891002739 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 146891002740 ski2-like helicase; Provisional; Region: PRK00254 146891002741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002742 active site 146891002743 mercuric reductase; Region: MerA; TIGR02053 146891002744 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 146891002745 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 146891002746 active site pocket [active] 146891002747 oxyanion hole [active] 146891002748 catalytic triad [active] 146891002749 active site nucleophile [active] 146891002750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 146891002751 Coenzyme A binding pocket [chemical binding]; other site 146891002752 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891002753 Protein of unknown function, DUF393; Region: DUF393; cl01136 146891002754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891002755 aminopeptidase N; Provisional; Region: pepN; PRK14015 146891002756 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 146891002757 Zn binding site [ion binding]; other site 146891002758 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 146891002759 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891002760 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 146891002761 catalytic residues [active] 146891002762 dimer interface [polypeptide binding]; other site 146891002763 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 146891002764 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 146891002765 FMN binding site [chemical binding]; other site 146891002766 active site 146891002767 catalytic residues [active] 146891002768 substrate binding site [chemical binding]; other site 146891002769 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 146891002770 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 146891002771 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 146891002772 active site 146891002773 Restriction endonuclease; Region: Mrr_cat; cl00747 146891002774 MAPEG family; Region: MAPEG; cl09190 146891002775 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 146891002776 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 146891002777 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891002778 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 146891002779 OsmC-like protein; Region: OsmC; cl00767 146891002780 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 146891002781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 146891002782 dimer interface [polypeptide binding]; other site 146891002783 putative PBP binding regions; other site 146891002784 ABC-ATPase subunit interface; other site 146891002785 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 146891002786 metal binding site 2 [ion binding]; metal-binding site 146891002787 putative DNA binding helix; other site 146891002788 metal binding site 1 [ion binding]; metal-binding site 146891002789 dimer interface [polypeptide binding]; other site 146891002790 structural Zn2+ binding site [ion binding]; other site 146891002791 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 146891002792 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 146891002793 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 146891002794 intersubunit interface [polypeptide binding]; other site 146891002795 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 146891002796 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 146891002797 P-loop, Walker A motif; other site 146891002798 Base recognition motif; other site 146891002799 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 146891002800 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 146891002801 structural tetrad; other site 146891002802 Uncharacterized conserved protein [Function unknown]; Region: COG2308 146891002803 Domain of unknown function (DUF404); Region: DUF404; pfam04169 146891002804 Domain of unknown function (DUF407); Region: DUF407; pfam04174 146891002805 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 146891002806 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 146891002807 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 146891002808 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 146891002809 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002810 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891002811 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 146891002812 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891002813 substrate binding site [chemical binding]; other site 146891002814 ATP binding site [chemical binding]; other site 146891002815 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 146891002816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 146891002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 146891002818 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 146891002819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 146891002820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 146891002821 dimer interface [polypeptide binding]; other site 146891002822 conserved gate region; other site 146891002823 putative PBP binding loops; other site 146891002824 ABC-ATPase subunit interface; other site 146891002825 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 146891002826 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 146891002827 homoserine dehydrogenase; Provisional; Region: PRK06349 146891002828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002829 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 146891002830 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 146891002831 Fe-S metabolism associated domain; Region: SufE; cl00951 146891002832 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 146891002833 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 146891002834 active site 146891002835 putative DNA-binding cleft [nucleotide binding]; other site 146891002836 dimer interface [polypeptide binding]; other site 146891002837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002838 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 146891002839 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 146891002840 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 146891002841 Cytochrome c; Region: Cytochrom_C; cl11414 146891002842 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 146891002843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891002844 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 146891002845 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 146891002846 putative active site [active] 146891002847 oxyanion strand; other site 146891002848 catalytic triad [active] 146891002849 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 146891002850 catalytic residues [active] 146891002851 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 146891002852 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 146891002853 phosphate binding site [ion binding]; other site 146891002854 DNA gyrase subunit A; Validated; Region: PRK05560 146891002855 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 146891002856 CAP-like domain; other site 146891002857 active site 146891002858 primary dimer interface [polypeptide binding]; other site 146891002859 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002860 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002863 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 146891002865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891002866 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 146891002867 Uncharacterized conserved protein [Function unknown]; Region: COG1543 146891002868 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 146891002869 2-isopropylmalate synthase; Validated; Region: PRK00915 146891002870 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 146891002871 active site 146891002872 catalytic residues [active] 146891002873 metal binding site [ion binding]; metal-binding site 146891002874 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 146891002875 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 146891002876 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 146891002877 Zn2+ binding site [ion binding]; other site 146891002878 Mg2+ binding site [ion binding]; other site 146891002879 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 146891002880 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 146891002881 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 146891002882 homodimer interface [polypeptide binding]; other site 146891002883 NADP binding site [chemical binding]; other site 146891002884 substrate binding site [chemical binding]; other site 146891002885 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 146891002886 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 146891002887 substrate binding pocket [chemical binding]; other site 146891002888 chain length determination region; other site 146891002889 substrate-Mg2+ binding site; other site 146891002890 catalytic residues [active] 146891002891 aspartate-rich region 1; other site 146891002892 active site lid residues [active] 146891002893 aspartate-rich region 2; other site 146891002894 Divergent PAP2 family; Region: DUF212; cl00855 146891002895 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 146891002896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002897 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 146891002898 catalytic triad [active] 146891002899 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 146891002900 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 146891002901 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 146891002902 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 146891002903 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 146891002904 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 146891002905 dimerization interface [polypeptide binding]; other site 146891002906 FAD binding pocket [chemical binding]; other site 146891002907 FAD binding motif [chemical binding]; other site 146891002908 catalytic residues [active] 146891002909 NAD binding pocket [chemical binding]; other site 146891002910 phosphate binding motif [ion binding]; other site 146891002911 beta-alpha-beta structure motif; other site 146891002912 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 146891002913 hydrophobic ligand binding site; other site 146891002914 adaptive-response sensory kinase; Validated; Region: PRK09303 146891002915 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 146891002916 tetramer interface [polypeptide binding]; other site 146891002917 dimer interface [polypeptide binding]; other site 146891002918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 146891002919 dimer interface [polypeptide binding]; other site 146891002920 phosphorylation site [posttranslational modification] 146891002921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891002922 ATP binding site [chemical binding]; other site 146891002923 Mg2+ binding site [ion binding]; other site 146891002924 G-X-G motif; other site 146891002925 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891002926 ribose-phosphate pyrophosphokinase; Region: PLN02369 146891002927 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 146891002928 Helix-turn-helix domains; Region: HTH; cl00088 146891002929 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 146891002930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891002931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891002932 catalytic residue [active] 146891002933 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 146891002934 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 146891002935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 146891002936 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 146891002937 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 146891002938 active site 146891002939 NAD binding site [chemical binding]; other site 146891002940 metal binding site [ion binding]; metal-binding site 146891002941 Clp protease ATP binding subunit; Region: clpC; CHL00095 146891002942 Clp amino terminal domain; Region: Clp_N; pfam02861 146891002943 Clp amino terminal domain; Region: Clp_N; pfam02861 146891002944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891002945 Walker A motif; other site 146891002946 ATP binding site [chemical binding]; other site 146891002947 Walker B motif; other site 146891002948 arginine finger; other site 146891002949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891002950 Walker A motif; other site 146891002951 ATP binding site [chemical binding]; other site 146891002952 Walker B motif; other site 146891002953 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 146891002954 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 146891002955 diaminopimelate decarboxylase; Region: lysA; TIGR01048 146891002956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 146891002957 active site 146891002958 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891002959 substrate binding site [chemical binding]; other site 146891002960 catalytic residues [active] 146891002961 dimer interface [polypeptide binding]; other site 146891002962 TIGR00159 family protein; Region: TIGR00159 146891002963 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 146891002964 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 146891002965 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 146891002966 catalytic residue [active] 146891002967 putative FPP diphosphate binding site; other site 146891002968 putative FPP binding hydrophobic cleft; other site 146891002969 dimer interface [polypeptide binding]; other site 146891002970 putative IPP diphosphate binding site; other site 146891002971 biotin synthase; Region: bioB; TIGR00433 146891002972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891002973 FeS/SAM binding site; other site 146891002974 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 146891002975 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 146891002976 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 146891002977 active site residue [active] 146891002978 lipoyl synthase; Provisional; Region: PRK12928 146891002979 recombination protein RecR; Reviewed; Region: recR; PRK00076 146891002980 RecR protein; Region: RecR; pfam02132 146891002981 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 146891002982 putative active site [active] 146891002983 putative metal-binding site [ion binding]; other site 146891002984 tetramer interface [polypeptide binding]; other site 146891002985 PsbP; Region: PsbP; cl03356 146891002986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 146891002987 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 146891002988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891002989 Walker A/P-loop; other site 146891002990 ATP binding site [chemical binding]; other site 146891002991 Q-loop/lid; other site 146891002992 ABC transporter signature motif; other site 146891002993 Walker B; other site 146891002994 D-loop; other site 146891002995 H-loop/switch region; other site 146891002996 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 146891002997 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 146891002998 ATP binding site [chemical binding]; other site 146891002999 Mg++ binding site [ion binding]; other site 146891003000 motif III; other site 146891003001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891003002 nucleotide binding region [chemical binding]; other site 146891003003 ATP-binding site [chemical binding]; other site 146891003004 DbpA RNA binding domain; Region: DbpA; pfam03880 146891003005 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 146891003006 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 146891003007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003009 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 146891003010 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 146891003011 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 146891003012 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 146891003013 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 146891003014 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 146891003015 active site 146891003016 hydrophilic channel; other site 146891003017 dimerization interface [polypeptide binding]; other site 146891003018 catalytic residues [active] 146891003019 active site lid [active] 146891003020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 146891003021 putative acyl-acceptor binding pocket; other site 146891003022 BolA-like protein; Region: BolA; cl00386 146891003023 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 146891003024 putative GSH binding site [chemical binding]; other site 146891003025 catalytic residues [active] 146891003026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 146891003027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891003028 active site 146891003029 phosphorylation site [posttranslational modification] 146891003030 intermolecular recognition site; other site 146891003031 dimerization interface [polypeptide binding]; other site 146891003032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891003033 DNA binding site [nucleotide binding] 146891003034 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 146891003035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003036 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 146891003037 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 146891003038 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 146891003039 putative high light inducible protein; Region: PHA02337 146891003040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891003041 TPR motif; other site 146891003042 binding surface 146891003043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891003044 TPR motif; other site 146891003045 binding surface 146891003046 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 146891003047 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891003048 YadA-like C-terminal region; Region: YadA; pfam03895 146891003049 Autotransporter beta-domain; Region: Autotransporter; cl02365 146891003050 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 146891003051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891003052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891003053 DNA binding residues [nucleotide binding] 146891003054 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 146891003055 Ca2+ binding site [ion binding]; other site 146891003056 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003057 putative high light inducible protein; Region: PHA02337 146891003058 putative high light inducible protein; Region: PHA02337 146891003059 Protein of unknown function; Region: DUF3721; pfam12518 146891003060 DsrE/DsrF-like family; Region: DrsE; cl00672 146891003061 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 146891003062 putative high light inducible protein; Region: PHA02337 146891003063 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 146891003064 protein I interface; other site 146891003065 D2 interface; other site 146891003066 protein T interface; other site 146891003067 chlorophyll binding site; other site 146891003068 beta carotene binding site; other site 146891003069 pheophytin binding site; other site 146891003070 manganese-stabilizing polypeptide interface; other site 146891003071 CP43 interface; other site 146891003072 protein L interface; other site 146891003073 oxygen evolving complex binding site; other site 146891003074 bromide binding site; other site 146891003075 quinone binding site; other site 146891003076 Fe binding site [ion binding]; other site 146891003077 core light harvesting interface; other site 146891003078 cytochrome b559 alpha subunit interface; other site 146891003079 cytochrome c-550 interface; other site 146891003080 protein J interface; other site 146891003081 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 146891003082 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891003083 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 146891003084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003085 domain; Region: Succ_DH_flav_C; pfam02910 146891003086 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 146891003087 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 146891003088 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891003089 RNA binding surface [nucleotide binding]; other site 146891003090 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 146891003091 probable active site [active] 146891003092 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003093 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 146891003094 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 146891003095 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003096 Kinesin-associated protein (KAP); Region: KAP; pfam05804 146891003097 Protein of unknown function, DUF; Region: DUF411; cl01142 146891003098 Protein of unknown function; Region: DUF3721; pfam12518 146891003099 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891003100 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891003101 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 146891003102 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 146891003103 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 146891003104 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 146891003105 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 146891003106 Cupin domain; Region: Cupin_2; cl09118 146891003107 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 146891003108 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 146891003109 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 146891003110 catalytic triad [active] 146891003111 putative high light inducible protein; Region: PHA02337 146891003112 putative high light inducible protein; Region: PHA02337 146891003113 putative high light inducible protein; Region: PHA02337 146891003114 putative high light inducible protein; Region: PHA02337 146891003115 GTP-binding protein YchF; Reviewed; Region: PRK09601 146891003116 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 146891003117 G1 box; other site 146891003118 GTP/Mg2+ binding site [chemical binding]; other site 146891003119 Switch I region; other site 146891003120 G2 box; other site 146891003121 Switch II region; other site 146891003122 G3 box; other site 146891003123 G4 box; other site 146891003124 G5 box; other site 146891003125 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 146891003126 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 146891003127 DNA polymerase I; Provisional; Region: PRK05755 146891003128 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 146891003129 active site 146891003130 metal binding site 1 [ion binding]; metal-binding site 146891003131 putative 5' ssDNA interaction site; other site 146891003132 metal binding site 3; metal-binding site 146891003133 metal binding site 2 [ion binding]; metal-binding site 146891003134 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 146891003135 putative DNA binding site [nucleotide binding]; other site 146891003136 putative metal binding site [ion binding]; other site 146891003137 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 146891003138 active site 146891003139 catalytic site [active] 146891003140 substrate binding site [chemical binding]; other site 146891003141 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 146891003142 active site 146891003143 DNA binding site [nucleotide binding] 146891003144 catalytic site [active] 146891003145 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 146891003146 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891003147 active site 146891003148 HIGH motif; other site 146891003149 nucleotide binding site [chemical binding]; other site 146891003150 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 146891003151 KMSKS motif; other site 146891003152 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 146891003153 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 146891003154 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 146891003155 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 146891003156 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 146891003157 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 146891003158 dimer interface [polypeptide binding]; other site 146891003159 [2Fe-2S] cluster binding site [ion binding]; other site 146891003160 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 146891003161 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 146891003162 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 146891003163 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 146891003164 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 146891003165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003166 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 146891003167 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 146891003168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003169 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 146891003170 catalytic residues [active] 146891003171 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 146891003172 rRNA binding site [nucleotide binding]; other site 146891003173 predicted 30S ribosome binding site; other site 146891003174 Ycf39; Provisional; Region: ycf39; CHL00194 146891003175 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 146891003176 NAD(P) binding site [chemical binding]; other site 146891003177 putative active site [active] 146891003178 PetM family of cytochrome b6f complex subunit 7; Region: PetM; cl15715 146891003179 hydrolase; Region: PLN02578 146891003180 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 146891003181 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 146891003182 putative valine binding site [chemical binding]; other site 146891003183 dimer interface [polypeptide binding]; other site 146891003184 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 146891003185 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 146891003186 active site 146891003187 Ycf4; Region: Ycf4; cl03567 146891003188 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 146891003189 pheophytin binding site; other site 146891003190 chlorophyll binding site; other site 146891003191 quinone binding site; other site 146891003192 Fe binding site [ion binding]; other site 146891003193 Photosystem II protein; Region: PSII; cl08223 146891003194 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 146891003195 Maf-like protein; Region: Maf; pfam02545 146891003196 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 146891003197 active site 146891003198 dimer interface [polypeptide binding]; other site 146891003199 cobyric acid synthase; Provisional; Region: PRK00784 146891003200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003201 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 146891003202 catalytic triad [active] 146891003203 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 146891003204 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891003205 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891003206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003207 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 146891003208 ligand binding site; other site 146891003209 tetramer interface; other site 146891003210 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 146891003211 putative active site [active] 146891003212 putative substrate binding site [chemical binding]; other site 146891003213 putative cosubstrate binding site; other site 146891003214 catalytic site [active] 146891003215 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 146891003216 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 146891003217 metal binding site [ion binding]; metal-binding site 146891003218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003219 S-adenosylmethionine binding site [chemical binding]; other site 146891003220 Rhomboid family; Region: Rhomboid; cl11446 146891003221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 146891003222 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 146891003223 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 146891003224 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 146891003225 dimer interface [polypeptide binding]; other site 146891003226 active site 146891003227 motif 2; other site 146891003228 motif 3; other site 146891003229 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 146891003230 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 146891003231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003232 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 146891003233 Photosystem II protein; Region: PSII; cl08223 146891003234 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 146891003235 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 146891003236 PQ loop repeat; Region: PQ-loop; cl12056 146891003237 Membrane transport protein; Region: Mem_trans; cl09117 146891003238 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 146891003239 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 146891003240 Polycystin cation channel protein; Provisional; Region: PLN03223 146891003241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891003242 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 146891003243 putative ADP-binding pocket [chemical binding]; other site 146891003244 EamA-like transporter family; Region: EamA; cl01037 146891003245 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 146891003246 EamA-like transporter family; Region: EamA; cl01037 146891003247 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 146891003248 tandem repeat interface [polypeptide binding]; other site 146891003249 oligomer interface [polypeptide binding]; other site 146891003250 active site residues [active] 146891003251 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 146891003252 active site 146891003253 homotrimer interaction site [polypeptide binding]; other site 146891003254 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 146891003255 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 146891003256 Bacterial membrane flanked domain; Region: DUF304; cl01348 146891003257 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 146891003258 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 146891003259 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 146891003260 Ycf46; Provisional; Region: ycf46; CHL00195 146891003261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891003262 Walker A motif; other site 146891003263 ATP binding site [chemical binding]; other site 146891003264 Walker B motif; other site 146891003265 arginine finger; other site 146891003266 seryl-tRNA synthetase; Provisional; Region: PRK05431 146891003267 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 146891003268 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 146891003269 dimer interface [polypeptide binding]; other site 146891003270 active site 146891003271 motif 1; other site 146891003272 motif 2; other site 146891003273 motif 3; other site 146891003274 RIP metalloprotease RseP; Region: TIGR00054 146891003275 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 146891003276 active site 146891003277 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 146891003278 protein binding site [polypeptide binding]; other site 146891003279 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 146891003280 putative substrate binding region [chemical binding]; other site 146891003281 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 146891003282 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 146891003283 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 146891003284 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 146891003285 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 146891003286 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 146891003287 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 146891003288 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 146891003289 putative nucleic acid binding region [nucleotide binding]; other site 146891003290 G-X-X-G motif; other site 146891003291 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 146891003292 RNA binding site [nucleotide binding]; other site 146891003293 domain interface; other site 146891003294 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 146891003295 active site 146891003296 Predicted methyltransferases [General function prediction only]; Region: COG0313 146891003297 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 146891003298 O-Antigen ligase; Region: Wzy_C; cl04850 146891003299 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 146891003300 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 146891003301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891003303 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 146891003304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 146891003305 active site 146891003306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891003307 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 146891003308 putative ADP-binding pocket [chemical binding]; other site 146891003309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003310 active site 146891003311 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 146891003312 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 146891003313 Mg++ binding site [ion binding]; other site 146891003314 putative catalytic motif [active] 146891003315 substrate binding site [chemical binding]; other site 146891003316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891003317 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 146891003318 putative NAD(P) binding site [chemical binding]; other site 146891003319 active site 146891003320 putative substrate binding site [chemical binding]; other site 146891003321 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 146891003322 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 146891003323 Substrate binding site; other site 146891003324 Cupin domain; Region: Cupin_2; cl09118 146891003325 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 146891003326 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 146891003327 NADP-binding site; other site 146891003328 homotetramer interface [polypeptide binding]; other site 146891003329 substrate binding site [chemical binding]; other site 146891003330 homodimer interface [polypeptide binding]; other site 146891003331 active site 146891003332 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 146891003333 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 146891003334 NADP binding site [chemical binding]; other site 146891003335 active site 146891003336 putative substrate binding site [chemical binding]; other site 146891003337 Chain length determinant protein; Region: Wzz; cl01623 146891003338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003339 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 146891003340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003341 active site 146891003342 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 146891003343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003344 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 146891003345 Cupin domain; Region: Cupin_2; cl09118 146891003346 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 146891003347 substrate binding site; other site 146891003348 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 146891003349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003350 Walker A/P-loop; other site 146891003351 ATP binding site [chemical binding]; other site 146891003352 Q-loop/lid; other site 146891003353 ABC transporter signature motif; other site 146891003354 Walker B; other site 146891003355 D-loop; other site 146891003356 H-loop/switch region; other site 146891003357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 146891003358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003359 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 146891003360 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 146891003361 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 146891003362 inhibitor-cofactor binding pocket; inhibition site 146891003363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891003364 catalytic residue [active] 146891003365 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 146891003366 putative trimer interface [polypeptide binding]; other site 146891003367 putative active site [active] 146891003368 putative substrate binding site [chemical binding]; other site 146891003369 putative CoA binding site [chemical binding]; other site 146891003370 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 146891003371 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 146891003372 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 146891003373 NAD(P) binding site [chemical binding]; other site 146891003374 homodimer interface [polypeptide binding]; other site 146891003375 substrate binding site [chemical binding]; other site 146891003376 active site 146891003377 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 146891003378 Mg++ binding site [ion binding]; other site 146891003379 putative catalytic motif [active] 146891003380 putative substrate binding site [chemical binding]; other site 146891003381 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 146891003382 Ligand Binding Site [chemical binding]; other site 146891003383 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 146891003384 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 146891003385 phosphate binding site [ion binding]; other site 146891003386 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 146891003387 conserved cys residue [active] 146891003388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003389 extended (e) SDRs; Region: SDR_e; cd08946 146891003390 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891003391 NAD(P) binding site [chemical binding]; other site 146891003392 active site 146891003393 substrate binding site [chemical binding]; other site 146891003394 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891003395 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891003396 extended (e) SDRs; Region: SDR_e; cd08946 146891003397 NAD(P) binding site [chemical binding]; other site 146891003398 active site 146891003399 substrate binding site [chemical binding]; other site 146891003400 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 146891003401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003402 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 146891003403 NeuB family; Region: NeuB; cl00496 146891003404 SAF domain; Region: SAF; cl00555 146891003405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003406 active site 146891003407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 146891003408 active site 146891003409 UDP-glucose 4-epimerase; Region: PLN02240 146891003410 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 146891003411 NAD binding site [chemical binding]; other site 146891003412 homodimer interface [polypeptide binding]; other site 146891003413 active site 146891003414 substrate binding site [chemical binding]; other site 146891003415 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 146891003416 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 146891003417 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 146891003418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003419 Walker A/P-loop; other site 146891003420 ATP binding site [chemical binding]; other site 146891003421 Q-loop/lid; other site 146891003422 ABC transporter signature motif; other site 146891003423 Walker B; other site 146891003424 D-loop; other site 146891003425 H-loop/switch region; other site 146891003426 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 146891003427 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 146891003428 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 146891003429 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 146891003430 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 146891003431 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 146891003432 RTX N-terminal domain; Region: RTX; pfam02382 146891003433 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate; Region: CA; cl02468 146891003434 Ca2+ binding site [ion binding]; other site 146891003435 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell fate; Region: CA; cl02468 146891003436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 146891003438 active site 146891003439 motif I; other site 146891003440 motif II; other site 146891003441 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 146891003442 active site 146891003443 Substrate binding site; other site 146891003444 Mg++ binding site; other site 146891003445 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 146891003446 dimer interface [polypeptide binding]; other site 146891003447 active site 146891003448 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891003449 active site 146891003450 nucleotide binding site [chemical binding]; other site 146891003451 HIGH motif; other site 146891003452 KMSKS motif; other site 146891003453 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 146891003454 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891003455 putative ribose interaction site [chemical binding]; other site 146891003456 putative ADP binding site [chemical binding]; other site 146891003457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891003458 extended (e) SDRs; Region: SDR_e; cd08946 146891003459 NAD(P) binding site [chemical binding]; other site 146891003460 active site 146891003461 substrate binding site [chemical binding]; other site 146891003462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 146891003464 active site 146891003465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003466 S-adenosylmethionine binding site [chemical binding]; other site 146891003467 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 146891003468 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 146891003469 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 146891003470 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 146891003471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003472 Walker A/P-loop; other site 146891003473 ATP binding site [chemical binding]; other site 146891003474 Q-loop/lid; other site 146891003475 ABC transporter signature motif; other site 146891003476 Walker B; other site 146891003477 D-loop; other site 146891003478 H-loop/switch region; other site 146891003479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003480 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 146891003481 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 146891003482 NAD(P) binding site [chemical binding]; other site 146891003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003484 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 146891003485 NAD(P) binding site [chemical binding]; other site 146891003486 active site 146891003487 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 146891003488 TPP-binding site [chemical binding]; other site 146891003489 dimer interface [polypeptide binding]; other site 146891003490 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 146891003491 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 146891003492 PYR/PP interface [polypeptide binding]; other site 146891003493 dimer interface [polypeptide binding]; other site 146891003494 TPP binding site [chemical binding]; other site 146891003495 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891003496 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 146891003497 extended (e) SDRs; Region: SDR_e; cd08946 146891003498 NAD(P) binding site [chemical binding]; other site 146891003499 active site 146891003500 substrate binding site [chemical binding]; other site 146891003501 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 146891003502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003504 SOS regulatory protein LexA; Region: lexA; TIGR00498 146891003505 Helix-turn-helix domains; Region: HTH; cl00088 146891003506 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 146891003507 Catalytic site [active] 146891003508 ornithine carbamoyltransferase; Provisional; Region: PRK00779 146891003509 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 146891003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003511 FtsH Extracellular; Region: FtsH_ext; pfam06480 146891003512 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 146891003513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891003514 Walker A motif; other site 146891003515 ATP binding site [chemical binding]; other site 146891003516 Walker B motif; other site 146891003517 arginine finger; other site 146891003518 Peptidase family M41; Region: Peptidase_M41; pfam01434 146891003519 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 146891003520 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 146891003521 catalytic motif [active] 146891003522 Zn binding site [ion binding]; other site 146891003523 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 146891003524 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 146891003525 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 146891003526 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 146891003527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003528 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 146891003529 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 146891003530 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 146891003531 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 146891003532 dimer interface [polypeptide binding]; other site 146891003533 motif 1; other site 146891003534 active site 146891003535 motif 2; other site 146891003536 motif 3; other site 146891003537 Survival protein SurE; Region: SurE; cl00448 146891003538 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 146891003539 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 146891003540 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 146891003541 active site 146891003542 Riboflavin kinase; Region: Flavokinase; cl03312 146891003543 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 146891003544 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 146891003545 thiamine phosphate binding site [chemical binding]; other site 146891003546 active site 146891003547 pyrophosphate binding site [ion binding]; other site 146891003548 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 146891003549 thiS-thiF/thiG interaction site; other site 146891003550 AIR carboxylase; Region: AIRC; cl00310 146891003551 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 146891003552 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 146891003553 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 146891003554 homotrimer interaction site [polypeptide binding]; other site 146891003555 zinc binding site [ion binding]; other site 146891003556 CDP-binding sites; other site 146891003557 GTPase Era; Reviewed; Region: era; PRK00089 146891003558 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 146891003559 G1 box; other site 146891003560 GTP/Mg2+ binding site [chemical binding]; other site 146891003561 Switch I region; other site 146891003562 G2 box; other site 146891003563 Switch II region; other site 146891003564 G3 box; other site 146891003565 G4 box; other site 146891003566 G5 box; other site 146891003567 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 146891003568 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 146891003569 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 146891003570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003571 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 146891003572 signal recognition particle protein; Provisional; Region: PRK10867 146891003573 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 146891003574 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 146891003575 P loop; other site 146891003576 GTP binding site [chemical binding]; other site 146891003577 Signal peptide binding domain; Region: SRP_SPB; pfam02978 146891003578 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 146891003579 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 146891003580 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 146891003581 tetramer interface [polypeptide binding]; other site 146891003582 TPP-binding site [chemical binding]; other site 146891003583 heterodimer interface [polypeptide binding]; other site 146891003584 phosphorylation loop region [posttranslational modification] 146891003585 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891003586 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891003587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891003588 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891003589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891003590 DNA binding residues [nucleotide binding] 146891003591 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 146891003592 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 146891003593 putative substrate binding site [chemical binding]; other site 146891003594 putative ATP binding site [chemical binding]; other site 146891003595 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 146891003596 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 146891003597 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 146891003598 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 146891003599 putative active site [active] 146891003600 catalytic triad [active] 146891003601 putative dimer interface [polypeptide binding]; other site 146891003602 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 146891003603 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 146891003604 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 146891003605 Catalytic site [active] 146891003606 High-affinity nickel-transport protein; Region: NicO; cl00964 146891003607 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 146891003608 active site 146891003609 ribulose/triose binding site [chemical binding]; other site 146891003610 phosphate binding site [ion binding]; other site 146891003611 substrate (anthranilate) binding pocket [chemical binding]; other site 146891003612 product (indole) binding pocket [chemical binding]; other site 146891003613 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 146891003614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003616 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 146891003617 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 146891003618 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 146891003619 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 146891003620 hinge; other site 146891003621 active site 146891003622 acetylornithine aminotransferase; Provisional; Region: PRK02627 146891003623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 146891003624 inhibitor-cofactor binding pocket; inhibition site 146891003625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891003626 catalytic residue [active] 146891003627 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 146891003628 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 146891003629 FAD binding domain; Region: FAD_binding_4; pfam01565 146891003630 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 146891003631 active site 146891003632 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 146891003633 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 146891003634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891003635 FeS/SAM binding site; other site 146891003636 TRAM domain; Region: TRAM; cl01282 146891003637 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 146891003638 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 146891003639 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891003640 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 146891003641 cell division protein FtsZ; Validated; Region: PRK09330 146891003642 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 146891003643 nucleotide binding site [chemical binding]; other site 146891003644 SulA interaction site; other site 146891003645 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 146891003646 oligomerization interface [polypeptide binding]; other site 146891003647 active site 146891003648 metal binding site [ion binding]; metal-binding site 146891003649 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 146891003650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891003651 FeS/SAM binding site; other site 146891003652 HemN C-terminal region; Region: HemN_C; pfam06969 146891003653 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 146891003654 putative active site [active] 146891003655 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891003656 oligomer interface [polypeptide binding]; other site 146891003657 active site residues [active] 146891003658 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891003659 oligomer interface [polypeptide binding]; other site 146891003660 active site residues [active] 146891003661 ketol-acid reductoisomerase; Provisional; Region: PRK05479 146891003662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003663 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 146891003664 CobD/Cbib protein; Region: CobD_Cbib; cl00561 146891003665 light-harvesting-like protein 3; Provisional; Region: PLN00014 146891003666 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 146891003667 IHF dimer interface [polypeptide binding]; other site 146891003668 IHF - DNA interface [nucleotide binding]; other site 146891003669 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 146891003670 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 146891003671 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 146891003672 active site 146891003673 catalytic site [active] 146891003674 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 146891003675 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 146891003676 Domain of unknown function DUF140; Region: DUF140; cl00510 146891003677 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 146891003678 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 146891003679 Domain of unknown function (DUF205); Region: DUF205; cl00410 146891003680 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 146891003681 active site 146891003682 dimer interface [polypeptide binding]; other site 146891003683 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 146891003684 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 146891003685 active site 146891003686 HIGH motif; other site 146891003687 dimer interface [polypeptide binding]; other site 146891003688 KMSKS motif; other site 146891003689 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 146891003690 multifunctional aminopeptidase A; Provisional; Region: PRK00913 146891003691 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 146891003692 interface (dimer of trimers) [polypeptide binding]; other site 146891003693 Substrate-binding/catalytic site; other site 146891003694 Zn-binding sites [ion binding]; other site 146891003695 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 146891003696 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 146891003697 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891003698 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 146891003699 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 146891003700 active site 146891003701 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 146891003702 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 146891003703 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 146891003704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 146891003705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 146891003706 Surface antigen; Region: Bac_surface_Ag; cl03097 146891003707 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 146891003708 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 146891003709 ATP binding site [chemical binding]; other site 146891003710 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 146891003711 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 146891003712 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 146891003713 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 146891003714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 146891003715 dimerization interface [polypeptide binding]; other site 146891003716 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 146891003717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 146891003718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 146891003719 dimer interface [polypeptide binding]; other site 146891003720 phosphorylation site [posttranslational modification] 146891003721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891003722 ATP binding site [chemical binding]; other site 146891003723 Mg2+ binding site [ion binding]; other site 146891003724 G-X-G motif; other site 146891003725 circadian clock protein KaiC; Reviewed; Region: PRK09302 146891003726 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 146891003727 Walker A motif; other site 146891003728 ATP binding site [chemical binding]; other site 146891003729 Walker B motif; other site 146891003730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003732 Walker A motif; other site 146891003733 ATP binding site [chemical binding]; other site 146891003734 Walker B motif; other site 146891003735 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 146891003736 tetramer interface [polypeptide binding]; other site 146891003737 dimer interface [polypeptide binding]; other site 146891003738 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 146891003739 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 146891003740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003741 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 146891003742 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 146891003743 RNA binding site [nucleotide binding]; other site 146891003744 active site 146891003745 Stage II sporulation protein; Region: SpoIID; pfam08486 146891003746 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 146891003747 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891003748 secreted effector protein PipB; Provisional; Region: PRK15197 146891003749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 146891003750 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891003751 catalytic loop [active] 146891003752 iron binding site [ion binding]; other site 146891003753 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 146891003754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003755 S-adenosylmethionine binding site [chemical binding]; other site 146891003756 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 146891003757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003758 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 146891003759 putative L-serine binding site [chemical binding]; other site 146891003760 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 146891003761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 146891003762 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 146891003763 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 146891003764 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 146891003765 DoxX; Region: DoxX; cl00976 146891003766 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 146891003767 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 146891003768 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 146891003769 nucleotide binding pocket [chemical binding]; other site 146891003770 K-X-D-G motif; other site 146891003771 catalytic site [active] 146891003772 short chain dehydrogenase; Provisional; Region: PRK06197 146891003773 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 146891003774 putative NAD(P) binding site [chemical binding]; other site 146891003775 active site 146891003776 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 146891003777 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 146891003778 Pirin-related protein [General function prediction only]; Region: COG1741 146891003779 Cupin domain; Region: Cupin_2; cl09118 146891003780 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 146891003781 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 146891003782 GAF domain; Region: GAF; cl00853 146891003783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891003784 flavoprotein, HI0933 family; Region: TIGR00275 146891003785 Cupin domain; Region: Cupin_2; cl09118 146891003786 Protein of unknown function (DUF805); Region: DUF805; cl01224 146891003787 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 146891003788 putative di-iron ligands [ion binding]; other site 146891003789 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 146891003790 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 146891003791 Fatty acid desaturase; Region: FA_desaturase; pfam00487 146891003792 putative di-iron ligands [ion binding]; other site 146891003793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003794 putative high light inducible protein; Region: PHA02337 146891003795 putative high light inducible protein; Region: PHA02337 146891003796 putative high light inducible protein; Region: PHA02337 146891003797 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 146891003798 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 146891003799 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 146891003800 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 146891003801 DoxX; Region: DoxX; cl00976 146891003802 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 146891003803 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 146891003804 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 146891003805 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 146891003806 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 146891003807 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 146891003808 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 146891003809 EVE domain; Region: EVE; cl00728 146891003810 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 146891003811 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 146891003812 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 146891003813 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 146891003814 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 146891003815 Sulfatase; Region: Sulfatase; cl10460 146891003816 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 146891003817 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 146891003818 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 146891003819 ring oligomerisation interface [polypeptide binding]; other site 146891003820 ATP/Mg binding site [chemical binding]; other site 146891003821 stacking interactions; other site 146891003822 hinge regions; other site 146891003823 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 146891003824 oligomerisation interface [polypeptide binding]; other site 146891003825 mobile loop; other site 146891003826 roof hairpin; other site 146891003827 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 146891003828 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 146891003829 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 146891003830 alpha subunit interaction interface [polypeptide binding]; other site 146891003831 Walker A motif; other site 146891003832 ATP binding site [chemical binding]; other site 146891003833 Walker B motif; other site 146891003834 inhibitor binding site; inhibition site 146891003835 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 146891003836 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 146891003837 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 146891003838 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 146891003839 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 146891003840 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 146891003841 proline aminopeptidase P II; Provisional; Region: PRK10879 146891003842 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 146891003843 active site 146891003844 Domain of unknown function DUF21; Region: DUF21; pfam01595 146891003845 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 146891003846 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 146891003847 G1 box; other site 146891003848 GTP/Mg2+ binding site [chemical binding]; other site 146891003849 Switch I region; other site 146891003850 G2 box; other site 146891003851 Switch II region; other site 146891003852 G3 box; other site 146891003853 G4 box; other site 146891003854 Domain of unknown function (DUF697); Region: DUF697; cl12064 146891003855 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 146891003856 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 146891003857 active site 146891003858 (T/H)XGH motif; other site 146891003859 NAD synthetase; Provisional; Region: PRK13981 146891003860 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 146891003861 multimer interface [polypeptide binding]; other site 146891003862 active site 146891003863 catalytic triad [active] 146891003864 protein interface 1 [polypeptide binding]; other site 146891003865 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 146891003866 homodimer interface [polypeptide binding]; other site 146891003867 NAD binding pocket [chemical binding]; other site 146891003868 ATP binding pocket [chemical binding]; other site 146891003869 Mg binding site [ion binding]; other site 146891003870 active-site loop [active] 146891003871 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 146891003872 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 146891003873 catalytic loop [active] 146891003874 iron binding site [ion binding]; other site 146891003875 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 146891003876 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 146891003877 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 146891003878 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 146891003879 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 146891003880 beta subunit interaction interface [polypeptide binding]; other site 146891003881 Walker A motif; other site 146891003882 ATP binding site [chemical binding]; other site 146891003883 Walker B motif; other site 146891003884 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 146891003885 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 146891003886 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 146891003887 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 146891003888 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 146891003889 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 146891003890 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 146891003891 ATP synthase subunit C; Region: ATP-synt_C; cl00466 146891003892 ATP synthase A chain; Region: ATP-synt_A; cl00413 146891003893 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 146891003894 LysE type translocator; Region: LysE; cl00565 146891003895 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 146891003896 ResB-like family; Region: ResB; pfam05140 146891003897 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 146891003898 Nitrogen regulatory protein P-II; Region: P-II; cl00412 146891003899 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 146891003900 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 146891003901 RNA binding surface [nucleotide binding]; other site 146891003902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 146891003903 adenylosuccinate lyase; Provisional; Region: PRK07380 146891003904 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 146891003905 tetramer interface [polypeptide binding]; other site 146891003906 active site 146891003907 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 146891003908 fumarate hydratase; Reviewed; Region: fumC; PRK00485 146891003909 Class II fumarases; Region: Fumarase_classII; cd01362 146891003910 active site 146891003911 tetramer interface [polypeptide binding]; other site 146891003912 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 146891003913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891003914 ATP binding site [chemical binding]; other site 146891003915 putative Mg++ binding site [ion binding]; other site 146891003916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891003917 nucleotide binding region [chemical binding]; other site 146891003918 ATP-binding site [chemical binding]; other site 146891003919 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 146891003920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891003921 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 146891003922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891003923 catalytic residue [active] 146891003924 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 146891003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891003926 S-adenosylmethionine binding site [chemical binding]; other site 146891003927 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974 146891003928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891003929 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 146891003930 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 146891003931 inhibitor-cofactor binding pocket; inhibition site 146891003932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891003933 catalytic residue [active] 146891003934 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 146891003935 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 146891003936 HSP70 interaction site [polypeptide binding]; other site 146891003937 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 146891003938 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 146891003939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 146891003940 active site 146891003941 catalytic tetrad [active] 146891003942 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 146891003943 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 146891003944 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 146891003945 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 146891003946 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 146891003947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891003948 FeS/SAM binding site; other site 146891003949 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 146891003950 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 146891003951 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 146891003952 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 146891003953 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 146891003954 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 146891003955 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 146891003956 DNA binding site [nucleotide binding] 146891003957 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 146891003958 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 146891003959 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 146891003960 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 146891003961 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 146891003962 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 146891003963 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 146891003964 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 146891003965 RPB1 interaction site [polypeptide binding]; other site 146891003966 RPB10 interaction site [polypeptide binding]; other site 146891003967 RPB11 interaction site [polypeptide binding]; other site 146891003968 RPB3 interaction site [polypeptide binding]; other site 146891003969 RPB12 interaction site [polypeptide binding]; other site 146891003970 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 146891003971 active site 146891003972 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 146891003973 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 146891003974 histidinol dehydrogenase; Region: hisD; TIGR00069 146891003975 NAD binding site [chemical binding]; other site 146891003976 dimerization interface [polypeptide binding]; other site 146891003977 product binding site; other site 146891003978 substrate binding site [chemical binding]; other site 146891003979 zinc binding site [ion binding]; other site 146891003980 catalytic residues [active] 146891003981 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 146891003982 tetramer (dimer of dimers) interface [polypeptide binding]; other site 146891003983 active site 146891003984 dimer interface [polypeptide binding]; other site 146891003985 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 146891003986 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 146891003987 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 146891003988 protein binding site [polypeptide binding]; other site 146891003989 ribosome maturation protein RimP; Reviewed; Region: PRK00092 146891003990 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 146891003991 Sm1 motif; other site 146891003992 D3 - B interaction site; other site 146891003993 D1 - D2 interaction site; other site 146891003994 Hfq - Hfq interaction site; other site 146891003995 RNA binding pocket [nucleotide binding]; other site 146891003996 Sm2 motif; other site 146891003997 NusA N-terminal domain; Region: NusA_N; pfam08529 146891003998 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 146891003999 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 146891004000 RNA binding site [nucleotide binding]; other site 146891004001 homodimer interface [polypeptide binding]; other site 146891004002 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 146891004003 G-X-X-G motif; other site 146891004004 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 146891004005 translation initiation factor IF-2; Validated; Region: infB; PRK05306 146891004006 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 146891004007 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 146891004008 G1 box; other site 146891004009 putative GEF interaction site [polypeptide binding]; other site 146891004010 GTP/Mg2+ binding site [chemical binding]; other site 146891004011 Switch I region; other site 146891004012 G2 box; other site 146891004013 G3 box; other site 146891004014 Switch II region; other site 146891004015 G4 box; other site 146891004016 G5 box; other site 146891004017 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 146891004018 Translation-initiation factor 2; Region: IF-2; pfam11987 146891004019 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 146891004020 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 146891004021 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 146891004022 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 146891004023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 146891004024 FeS/SAM binding site; other site 146891004025 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 146891004026 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 146891004027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 146891004028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004029 homodimer interface [polypeptide binding]; other site 146891004030 catalytic residue [active] 146891004031 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 146891004032 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 146891004033 homodimer interface [polypeptide binding]; other site 146891004034 oligonucleotide binding site [chemical binding]; other site 146891004035 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 146891004036 RNA/DNA hybrid binding site [nucleotide binding]; other site 146891004037 active site 146891004038 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 146891004039 prephenate dehydratase; Provisional; Region: PRK11898 146891004040 Prephenate dehydratase; Region: PDT; pfam00800 146891004041 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 146891004042 putative L-Phe binding site [chemical binding]; other site 146891004043 tocopherol O-methyltransferase; Region: PLN02244 146891004044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891004045 S-adenosylmethionine binding site [chemical binding]; other site 146891004046 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 146891004047 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 146891004048 elongation factor Tu; Reviewed; Region: PRK00049 146891004049 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 146891004050 G1 box; other site 146891004051 GEF interaction site [polypeptide binding]; other site 146891004052 GTP/Mg2+ binding site [chemical binding]; other site 146891004053 Switch I region; other site 146891004054 G2 box; other site 146891004055 G3 box; other site 146891004056 Switch II region; other site 146891004057 G4 box; other site 146891004058 G5 box; other site 146891004059 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 146891004060 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 146891004061 Antibiotic Binding Site [chemical binding]; other site 146891004062 elongation factor G; Reviewed; Region: PRK00007 146891004063 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 146891004064 G1 box; other site 146891004065 putative GEF interaction site [polypeptide binding]; other site 146891004066 GTP/Mg2+ binding site [chemical binding]; other site 146891004067 Switch I region; other site 146891004068 G2 box; other site 146891004069 G3 box; other site 146891004070 Switch II region; other site 146891004071 G4 box; other site 146891004072 G5 box; other site 146891004073 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 146891004074 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 146891004075 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 146891004076 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 146891004077 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 146891004078 S17 interaction site [polypeptide binding]; other site 146891004079 S8 interaction site; other site 146891004080 16S rRNA interaction site [nucleotide binding]; other site 146891004081 streptomycin interaction site [chemical binding]; other site 146891004082 23S rRNA interaction site [nucleotide binding]; other site 146891004083 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 146891004084 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 146891004085 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 146891004086 active site 146891004087 dimer interface [polypeptide binding]; other site 146891004088 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 146891004089 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 146891004090 active site 146891004091 FMN binding site [chemical binding]; other site 146891004092 substrate binding site [chemical binding]; other site 146891004093 3Fe-4S cluster binding site [ion binding]; other site 146891004094 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 146891004095 domain interface; other site 146891004096 YCII-related domain; Region: YCII; cl00999 146891004097 lipoyl synthase; Provisional; Region: PRK05481 146891004098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 146891004099 FeS/SAM binding site; other site 146891004100 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 146891004101 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 146891004102 catalytic residues [active] 146891004103 catalytic nucleophile [active] 146891004104 Presynaptic Site I dimer interface [polypeptide binding]; other site 146891004105 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 146891004106 Synaptic Flat tetramer interface [polypeptide binding]; other site 146891004107 Synaptic Site I dimer interface [polypeptide binding]; other site 146891004108 DNA binding site [nucleotide binding] 146891004109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 146891004110 NlpC/P60 family; Region: NLPC_P60; cl11438 146891004111 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 146891004112 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 146891004113 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 146891004114 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 146891004115 Ligand binding site; other site 146891004116 Putative Catalytic site; other site 146891004117 DXD motif; other site 146891004118 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 146891004119 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 146891004120 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 146891004121 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 146891004122 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 146891004123 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 146891004124 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 146891004125 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 146891004126 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 146891004127 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 146891004128 alanine racemase; Reviewed; Region: alr; PRK00053 146891004129 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 146891004130 active site 146891004131 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 146891004132 dimer interface [polypeptide binding]; other site 146891004133 substrate binding site [chemical binding]; other site 146891004134 catalytic residues [active] 146891004135 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 146891004136 active site 146891004137 peptide chain release factor 1; Validated; Region: prfA; PRK00591 146891004138 RF-1 domain; Region: RF-1; cl02875 146891004139 RF-1 domain; Region: RF-1; cl02875 146891004140 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 146891004141 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 146891004142 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 146891004143 23S rRNA interface [nucleotide binding]; other site 146891004144 L3 interface [polypeptide binding]; other site 146891004145 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 146891004146 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 146891004147 dimerization interface 3.5A [polypeptide binding]; other site 146891004148 active site 146891004149 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 146891004150 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 146891004151 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 146891004152 alphaNTD homodimer interface [polypeptide binding]; other site 146891004153 alphaNTD - beta interaction site [polypeptide binding]; other site 146891004154 alphaNTD - beta' interaction site [polypeptide binding]; other site 146891004155 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 146891004156 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 146891004157 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 146891004158 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 146891004159 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 146891004160 adenylate kinase; Reviewed; Region: adk; PRK00279 146891004161 AMP-binding site [chemical binding]; other site 146891004162 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 146891004163 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 146891004164 SecY translocase; Region: SecY; pfam00344 146891004165 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 146891004166 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 146891004167 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 146891004168 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 146891004169 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 146891004170 5S rRNA interface [nucleotide binding]; other site 146891004171 L27 interface [polypeptide binding]; other site 146891004172 23S rRNA interface [nucleotide binding]; other site 146891004173 L5 interface [polypeptide binding]; other site 146891004174 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 146891004175 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 146891004176 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 146891004177 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 146891004178 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 146891004179 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 146891004180 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 146891004181 KOW motif; Region: KOW; cl00354 146891004182 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 146891004183 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 146891004184 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 146891004185 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 146891004186 23S rRNA interface [nucleotide binding]; other site 146891004187 putative translocon interaction site; other site 146891004188 signal recognition particle (SRP54) interaction site; other site 146891004189 L23 interface [polypeptide binding]; other site 146891004190 trigger factor interaction site; other site 146891004191 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 146891004192 23S rRNA interface [nucleotide binding]; other site 146891004193 5S rRNA interface [nucleotide binding]; other site 146891004194 putative antibiotic binding site [chemical binding]; other site 146891004195 L25 interface [polypeptide binding]; other site 146891004196 L27 interface [polypeptide binding]; other site 146891004197 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 146891004198 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 146891004199 G-X-X-G motif; other site 146891004200 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 146891004201 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 146891004202 putative translocon binding site; other site 146891004203 protein-rRNA interface [nucleotide binding]; other site 146891004204 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 146891004205 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 146891004206 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 146891004207 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 146891004208 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 146891004209 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 146891004210 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 146891004211 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 146891004212 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 146891004213 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 146891004214 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 146891004215 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 146891004216 recombinase A; Provisional; Region: recA; PRK09354 146891004217 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 146891004218 hexamer interface [polypeptide binding]; other site 146891004219 Walker A motif; other site 146891004220 ATP binding site [chemical binding]; other site 146891004221 Walker B motif; other site 146891004222 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 146891004223 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 146891004224 arogenate dehydrogenase; Reviewed; Region: PRK07417 146891004225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004226 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 146891004227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004228 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 146891004229 Phosphotransferase enzyme family; Region: APH; pfam01636 146891004230 Domain of unknown function (DUF4308); Region: DUF4308; cl14566 146891004231 hypothetical protein; Validated; Region: PRK07411 146891004232 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 146891004233 ATP binding site [chemical binding]; other site 146891004234 substrate interface [chemical binding]; other site 146891004235 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 146891004236 active site residue [active] 146891004237 hypothetical protein; Validated; Region: PRK07413 146891004238 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 146891004239 homodimer interface [polypeptide binding]; other site 146891004240 Walker A motif; other site 146891004241 ATP binding site [chemical binding]; other site 146891004242 hydroxycobalamin binding site [chemical binding]; other site 146891004243 Walker B motif; other site 146891004244 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 146891004245 Walker A motif; other site 146891004246 homodimer interface [polypeptide binding]; other site 146891004247 ATP binding site [chemical binding]; other site 146891004248 hydroxycobalamin binding site [chemical binding]; other site 146891004249 Walker B motif; other site 146891004250 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 146891004251 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 146891004252 Ligand Binding Site [chemical binding]; other site 146891004253 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 146891004254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891004255 Q-loop/lid; other site 146891004256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891004257 ABC transporter signature motif; other site 146891004258 Walker B; other site 146891004259 D-loop; other site 146891004260 H-loop/switch region; other site 146891004261 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 146891004262 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 146891004263 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 146891004264 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 146891004265 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 146891004266 chorismate binding enzyme; Region: Chorismate_bind; cl10555 146891004267 PsaD; Region: PsaD; cl03639 146891004268 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 146891004269 Domain of unknown function DUF59; Region: DUF59; cl00941 146891004270 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 146891004271 Walker A motif; other site 146891004272 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 146891004273 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 146891004274 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 146891004275 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 146891004276 putative active site [active] 146891004277 catalytic site [active] 146891004278 putative substrate binding site [chemical binding]; other site 146891004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 146891004280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 146891004281 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 146891004282 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 146891004283 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 146891004284 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 146891004285 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 146891004286 dimerization interface [polypeptide binding]; other site 146891004287 putative ATP binding site [chemical binding]; other site 146891004288 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 146891004289 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891004290 active site 146891004291 nucleotide binding site [chemical binding]; other site 146891004292 HIGH motif; other site 146891004293 KMSKS motif; other site 146891004294 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 146891004295 CMP-binding site; other site 146891004296 The sites determining sugar specificity; other site 146891004297 Low molecular weight phosphatase family; Region: LMWPc; cd00115 146891004298 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 146891004299 active site 146891004300 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 146891004301 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 146891004302 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 146891004303 heme binding pocket [chemical binding]; other site 146891004304 heme ligand [chemical binding]; other site 146891004305 isocitrate dehydrogenase; Validated; Region: PRK07362 146891004306 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 146891004307 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 146891004308 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 146891004309 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 146891004310 active site 146891004311 catalytic residues [active] 146891004312 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 146891004313 hydrolase; Region: PLN02578 146891004314 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 146891004315 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 146891004316 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 146891004317 homodimer interface [polypeptide binding]; other site 146891004318 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 146891004319 active site pocket [active] 146891004320 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 146891004321 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 146891004322 dimerization interface [polypeptide binding]; other site 146891004323 active site 146891004324 metal binding site [ion binding]; metal-binding site 146891004325 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 146891004326 dsRNA binding site [nucleotide binding]; other site 146891004327 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 146891004328 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 146891004329 RimM N-terminal domain; Region: RimM; pfam01782 146891004330 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 146891004331 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 146891004332 glutaminase active site [active] 146891004333 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 146891004334 dimer interface [polypeptide binding]; other site 146891004335 active site 146891004336 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 146891004337 dimer interface [polypeptide binding]; other site 146891004338 active site 146891004339 photosystem I subunit VII; Region: psaC; CHL00065 146891004340 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 146891004341 Phosphopantetheine attachment site; Region: PP-binding; cl09936 146891004342 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 146891004343 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 146891004344 dimer interface [polypeptide binding]; other site 146891004345 active site 146891004346 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 146891004347 transketolase; Region: PLN02790 146891004348 TPP-binding site [chemical binding]; other site 146891004349 dimer interface [polypeptide binding]; other site 146891004350 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 146891004351 PYR/PP interface [polypeptide binding]; other site 146891004352 dimer interface [polypeptide binding]; other site 146891004353 TPP binding site [chemical binding]; other site 146891004354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 146891004355 ThiC family; Region: ThiC; cl08031 146891004356 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 146891004357 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 146891004358 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 146891004359 metal binding site [ion binding]; metal-binding site 146891004360 dimer interface [polypeptide binding]; other site 146891004361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891004362 binding surface 146891004363 TPR motif; other site 146891004364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891004365 binding surface 146891004366 TPR motif; other site 146891004367 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 146891004368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891004369 Walker A motif; other site 146891004370 ATP binding site [chemical binding]; other site 146891004371 Walker B motif; other site 146891004372 arginine finger; other site 146891004373 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 146891004374 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 146891004375 SmpB-tmRNA interface; other site 146891004376 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 146891004377 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 146891004378 dimer interface [polypeptide binding]; other site 146891004379 putative anticodon binding site; other site 146891004380 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 146891004381 motif 1; other site 146891004382 active site 146891004383 motif 2; other site 146891004384 motif 3; other site 146891004385 Ycf27; Reviewed; Region: orf27; CHL00148 146891004386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 146891004387 active site 146891004388 phosphorylation site [posttranslational modification] 146891004389 intermolecular recognition site; other site 146891004390 dimerization interface [polypeptide binding]; other site 146891004391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 146891004392 DNA binding site [nucleotide binding] 146891004393 rod shape-determining protein MreC; Region: MreC; pfam04085 146891004394 rod shape-determining protein MreB; Provisional; Region: PRK13927 146891004395 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 146891004396 ATP binding site [chemical binding]; other site 146891004397 profilin binding site; other site 146891004398 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 146891004399 dimer interface [polypeptide binding]; other site 146891004400 ssDNA binding site [nucleotide binding]; other site 146891004401 tetramer (dimer of dimers) interface [polypeptide binding]; other site 146891004402 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 146891004403 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 146891004404 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 146891004405 oligomerization interface [polypeptide binding]; other site 146891004406 active site 146891004407 NAD+ binding site [chemical binding]; other site 146891004408 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 146891004409 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 146891004410 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 146891004411 putative substrate binding site [chemical binding]; other site 146891004412 putative ATP binding site [chemical binding]; other site 146891004413 hydrolase, alpha/beta fold family protein; Region: PLN02824 146891004414 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891004415 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891004416 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891004417 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891004418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 146891004419 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 146891004420 MgtE intracellular N domain; Region: MgtE_N; cl15244 146891004421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 146891004422 Divalent cation transporter; Region: MgtE; cl00786 146891004423 CrcB-like protein; Region: CRCB; cl09114 146891004424 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 146891004425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 146891004426 ATP binding site [chemical binding]; other site 146891004427 Mg2+ binding site [ion binding]; other site 146891004428 G-X-G motif; other site 146891004429 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 146891004430 anchoring element; other site 146891004431 dimer interface [polypeptide binding]; other site 146891004432 ATP binding site [chemical binding]; other site 146891004433 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 146891004434 active site 146891004435 putative metal-binding site [ion binding]; other site 146891004436 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 146891004437 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 146891004438 IPP transferase; Region: IPPT; cl00403 146891004439 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 146891004440 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 146891004441 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 146891004442 Predicted transcriptional regulators [Transcription]; Region: COG1725 146891004443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 146891004444 DNA-binding site [nucleotide binding]; DNA binding site 146891004445 serine O-acetyltransferase; Region: cysE; TIGR01172 146891004446 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 146891004447 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 146891004448 trimer interface [polypeptide binding]; other site 146891004449 active site 146891004450 substrate binding site [chemical binding]; other site 146891004451 CoA binding site [chemical binding]; other site 146891004452 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 146891004453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891004454 ATP binding site [chemical binding]; other site 146891004455 putative Mg++ binding site [ion binding]; other site 146891004456 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 146891004457 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 146891004458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 146891004459 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 146891004460 homopentamer interface [polypeptide binding]; other site 146891004461 active site 146891004462 YCF9; Region: Ycf9; cl09269 146891004463 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 146891004464 MutS domain I; Region: MutS_I; pfam01624 146891004465 MutS domain II; Region: MutS_II; pfam05188 146891004466 MutS family domain IV; Region: MutS_IV; pfam05190 146891004467 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 146891004468 Walker A/P-loop; other site 146891004469 ATP binding site [chemical binding]; other site 146891004470 Q-loop/lid; other site 146891004471 ABC transporter signature motif; other site 146891004472 Walker B; other site 146891004473 D-loop; other site 146891004474 H-loop/switch region; other site 146891004475 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 146891004476 Precorrin-8X methylmutase; Region: CbiC; pfam02570 146891004477 DNA polymerase III subunit delta; Validated; Region: PRK07452 146891004478 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 146891004479 aspartate kinase; Provisional; Region: PRK07431 146891004480 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 146891004481 putative nucleotide binding site [chemical binding]; other site 146891004482 putative catalytic residues [active] 146891004483 putative Mg ion binding site [ion binding]; other site 146891004484 putative aspartate binding site [chemical binding]; other site 146891004485 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 146891004486 putative allosteric regulatory site; other site 146891004487 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 146891004488 putative allosteric regulatory residue; other site 146891004489 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 146891004490 putative allosteric regulatory site; other site 146891004491 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 146891004492 putative allosteric regulatory residue; other site 146891004493 excinuclease ABC subunit B; Provisional; Region: PRK05298 146891004494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 146891004495 ATP binding site [chemical binding]; other site 146891004496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 146891004497 nucleotide binding region [chemical binding]; other site 146891004498 ATP-binding site [chemical binding]; other site 146891004499 Ultra-violet resistance protein B; Region: UvrB; pfam12344 146891004500 UvrB/uvrC motif; Region: UVR; pfam02151 146891004501 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 146891004502 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 146891004503 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 146891004504 Ligand Binding Site [chemical binding]; other site 146891004505 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 146891004506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 146891004507 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 146891004508 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 146891004509 dihydrodipicolinate synthase; Region: dapA; TIGR00674 146891004510 dimer interface [polypeptide binding]; other site 146891004511 active site 146891004512 catalytic residue [active] 146891004513 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 146891004514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004515 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 146891004516 trigger factor; Region: tig; TIGR00115 146891004517 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 146891004518 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 146891004519 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 146891004520 oligomer interface [polypeptide binding]; other site 146891004521 active site residues [active] 146891004522 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 146891004523 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 146891004524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891004525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891004526 Walker A motif; other site 146891004527 ATP binding site [chemical binding]; other site 146891004528 Walker B motif; other site 146891004529 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 146891004530 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 146891004531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 146891004532 Walker A motif; other site 146891004533 ATP binding site [chemical binding]; other site 146891004534 Walker B motif; other site 146891004535 arginine finger; other site 146891004536 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 146891004537 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 146891004538 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 146891004539 DXD motif; other site 146891004540 Stage II sporulation protein; Region: SpoIID; pfam08486 146891004541 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 146891004542 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 146891004543 ribosomal protein L20; Region: rpl20; CHL00068 146891004544 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 146891004545 23S rRNA binding site [nucleotide binding]; other site 146891004546 L21 binding site [polypeptide binding]; other site 146891004547 L13 binding site [polypeptide binding]; other site 146891004548 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 146891004549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 146891004550 binding surface 146891004551 TPR motif; other site 146891004552 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 146891004553 ThiS interaction site; other site 146891004554 putative active site [active] 146891004555 tetramer interface [polypeptide binding]; other site 146891004556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004557 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 146891004558 NAD(P) binding site [chemical binding]; other site 146891004559 active site 146891004560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 146891004561 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 146891004562 glycine dehydrogenase; Provisional; Region: PRK05367 146891004563 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891004564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891004565 catalytic residue [active] 146891004566 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 146891004567 tetramer interface [polypeptide binding]; other site 146891004568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004569 catalytic residue [active] 146891004570 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 146891004571 lipoyl attachment site [posttranslational modification]; other site 146891004572 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 146891004573 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 146891004574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 146891004575 catalytic residue [active] 146891004576 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 146891004577 Di-iron ligands [ion binding]; other site 146891004578 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 146891004579 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 146891004580 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 146891004581 replicative DNA helicase; Region: DnaB; TIGR00665 146891004582 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 146891004583 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 146891004584 Walker A motif; other site 146891004585 ATP binding site [chemical binding]; other site 146891004586 Walker B motif; other site 146891004587 DNA binding loops [nucleotide binding] 146891004588 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 146891004589 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 146891004590 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 146891004591 UTRA domain; Region: UTRA; cl01230 146891004592 SprT-like family; Region: SprT-like; pfam10263 146891004593 SprT homologues; Region: SprT; cl01182 146891004594 DNA ligase; Provisional; Region: 30; PHA02587 146891004595 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 146891004596 active site 146891004597 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 146891004598 DNA binding site [nucleotide binding] 146891004599 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 146891004600 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 146891004601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 146891004602 active site 146891004603 HIGH motif; other site 146891004604 nucleotide binding site [chemical binding]; other site 146891004605 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 146891004606 active site 146891004607 KMSKS motif; other site 146891004608 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 146891004609 tRNA binding surface [nucleotide binding]; other site 146891004610 anticodon binding site; other site 146891004611 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 146891004612 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 146891004613 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 146891004614 spermidine synthase; Provisional; Region: PRK00811 146891004615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 146891004616 S-adenosylmethionine binding site [chemical binding]; other site 146891004617 Arginase family; Region: Arginase; cl00306 146891004618 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 146891004619 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 146891004620 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 146891004621 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 146891004622 dimer interface [polypeptide binding]; other site 146891004623 anticodon binding site; other site 146891004624 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 146891004625 homodimer interface [polypeptide binding]; other site 146891004626 motif 1; other site 146891004627 active site 146891004628 motif 2; other site 146891004629 GAD domain; Region: GAD; pfam02938 146891004630 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 146891004631 active site 146891004632 motif 3; other site 146891004633 CTP synthetase; Validated; Region: pyrG; PRK05380 146891004634 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 146891004635 Catalytic site [active] 146891004636 active site 146891004637 UTP binding site [chemical binding]; other site 146891004638 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 146891004639 active site 146891004640 putative oxyanion hole; other site 146891004641 catalytic triad [active] 146891004642 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 146891004643 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 146891004644 Ligand Binding Site [chemical binding]; other site 146891004645 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 146891004646 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 146891004647 chorismate binding enzyme; Region: Chorismate_bind; cl10555 146891004648 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 146891004649 homodimer interface [polypeptide binding]; other site 146891004650 substrate-cofactor binding pocket; other site 146891004651 Aminotransferase class IV; Region: Aminotran_4; pfam01063 146891004652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004653 catalytic residue [active] 146891004654 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 146891004655 diphthine synthase; Region: dph5; TIGR00522 146891004656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 146891004657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 146891004658 polyphosphate kinase; Provisional; Region: PRK05443 146891004659 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 146891004660 putative domain interface [polypeptide binding]; other site 146891004661 putative active site [active] 146891004662 catalytic site [active] 146891004663 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 146891004664 putative domain interface [polypeptide binding]; other site 146891004665 putative active site [active] 146891004666 catalytic site [active] 146891004667 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 146891004668 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 146891004669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 146891004670 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 146891004671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 146891004672 DNA binding residues [nucleotide binding] 146891004673 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 146891004674 NeuB family; Region: NeuB; cl00496 146891004675 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 146891004676 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 146891004677 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 146891004678 substrate binding site [chemical binding]; other site 146891004679 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 146891004680 substrate binding site [chemical binding]; other site 146891004681 ligand binding site [chemical binding]; other site 146891004682 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 146891004683 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 146891004684 Cl- selectivity filter; other site 146891004685 Cl- binding residues [ion binding]; other site 146891004686 pore gating glutamate residue; other site 146891004687 dimer interface [polypeptide binding]; other site 146891004688 H+/Cl- coupling transport residue; other site 146891004689 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 146891004690 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 146891004691 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 146891004692 putative active site [active] 146891004693 putative substrate binding site [chemical binding]; other site 146891004694 putative cosubstrate binding site; other site 146891004695 catalytic site [active] 146891004696 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 146891004697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 146891004699 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 146891004700 StbA protein; Region: StbA; pfam06406 146891004701 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 146891004702 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 146891004703 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 146891004704 shikimate binding site; other site 146891004705 NAD(P) binding site [chemical binding]; other site 146891004706 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 146891004707 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 146891004708 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 146891004709 ANP binding site [chemical binding]; other site 146891004710 Substrate Binding Site II [chemical binding]; other site 146891004711 Substrate Binding Site I [chemical binding]; other site 146891004712 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 146891004713 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 146891004714 putative catalytic motif [active] 146891004715 putative substrate binding site [chemical binding]; other site 146891004716 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 146891004717 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 146891004718 putative ADP-binding pocket [chemical binding]; other site 146891004719 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 146891004720 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 146891004721 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 146891004722 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 146891004723 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 146891004724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 146891004725 Walker A/P-loop; other site 146891004726 ATP binding site [chemical binding]; other site 146891004727 Q-loop/lid; other site 146891004728 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 146891004729 ABC transporter signature motif; other site 146891004730 Walker B; other site 146891004731 D-loop; other site 146891004732 H-loop/switch region; other site 146891004733 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 146891004734 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 146891004735 active site 146891004736 substrate binding site [chemical binding]; other site 146891004737 ATP binding site [chemical binding]; other site 146891004738 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 146891004739 threonine synthase; Reviewed; Region: PRK06721 146891004740 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 146891004741 homodimer interface [polypeptide binding]; other site 146891004742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 146891004743 catalytic residue [active]