-- dump date 20120504_155031 -- class Genbank::CDS -- table cds_note -- id note NP_874395.1 binds the polymerase to DNA and acts as a sliding clamp NP_874396.1 protein implicated in RNA metabolism, contains two PRC-barrel domains NP_874397.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_874398.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_874403.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_874405.1 regulator of sigma subunit NP_874406.1 catalyzes the formation of arginine from (N-L-arginino)succinate NP_874409.1 domain frequently associated with peptide methionine sulfoxide reductase NP_874410.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_874411.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_874412.1 regulator of disulfide bond formation NP_874414.1 conserved in bacteria NP_874415.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_874419.1 cyclophilin family NP_874420.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_874422.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) NP_874431.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A NP_874432.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_874442.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_874443.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis NP_874446.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_874447.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_874448.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate NP_874449.1 HupE NP_874468.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_874471.1 specific for cyanobacteria membrane protein NP_874472.1 HLIP NP_874475.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_874480.1 with SufCD activates cysteine desulfurase SufS NP_874484.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate NP_874485.1 related to the helicase subunit of the Holliday junction resolvase NP_874486.1 HetI, homolog, see gi:20141367, COG2091 NP_874488.1 similar to Bvg accessory factor NP_874489.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite NP_874494.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling NP_874499.1 contains duplicated ATPase domains NP_874500.1 contains C-terminal PDZ domain NP_874502.1 conserved in cyanobacteria NP_874504.1 HLIP NP_874505.1 XseA NP_874506.1 XseB NP_874511.1 related to NifB/MoaA family NP_874512.1 conserved in cyanobacteria, possible transporter NP_874514.1 Probably membrane disulfide-isomerase NP_874516.2 Ycf7; cytochrome b6-f complex subunit 6; with PetG, PetM and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_874520.1 Only C-term. Domain unlike some other cyanobacteria NP_874522.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_874523.1 conserved in cyanobacteria NP_874525.1 conserved in cyanobacteria, possible transporter NP_874535.1 conserved in cyanobacteria NP_874538.1 conserved in cyanobacteria NP_874544.1 CheY-like receiver domain and a wHTH DNA-binding domain; OmpR homolog; similar to response regulator for energy transfer from phycobilismes to photosystems(rcpA,ycf27) NP_874545.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA NP_874546.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_874548.1 involved in photosystem I assembly, ycf3 chloroplast protein homolog NP_874549.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_874550.1 CheY-like receiver domain and a wHTH DNA-binding domain; OmpR homolog; similar to response regulator for energy transfer from phycobilismes to photosystems(rcpA,ycf27) NP_874551.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_874552.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_874556.1 molecular chaperone NP_874562.1 conserved in cyanobacteria NP_874563.1 conserved in cyanobacteria NP_874564.1 RbcR NP_874565.1 belongs to isoprenylcysteine O-methyltransferase family; Nitric dioxide metabolism PM: 9171397 NP_874566.1 Catalyzes the transfer of electrons from NADH to ubiquinone NP_874567.1 Shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain NP_874574.1 catalyzes the phosphorylation of NAD to NADP NP_874575.1 Catalyzes the transfer of electrons from NADH to quinone NP_874576.1 Catalyzes the transfer of electrons from NADH to quinone NP_874577.1 Catalyzes the transfer of electrons from NADH to quinone NP_874578.1 Catalyzes the transfer of electrons from NADH to quinone NP_874579.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate NP_874580.1 conserved in cyanobacteria NP_874582.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_874587.1 catalyzes the formation of Mg-protoporphyrin IX methyl ester and S-adenosyl-L-homocysteine from Mg-protoporphyrin IX and S-adenosyl-L-methionine NP_874588.1 CheY-like receiver and wHTH DNA-binding domains NP_874590.1 involved in cell envelope biogenesis NP_874591.1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradien NP_874593.1 Menaquinone biosynthesis NP_874594.1 Menaquinone biosynthesis NP_874595.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate NP_874597.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione NP_874599.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_874600.1 conserved in cyanobacteria NP_874604.1 Inactivated NP_874605.1 HisC NP_874606.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_874608.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_874612.1 contain duplicated ATPase NP_874614.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) NP_874615.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_874616.1 conserved in cyanobacteria NP_874619.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors NP_874621.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_874622.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_874623.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_874624.1 binds directly to 23S ribosomal RNA NP_874625.1 Modulates Rho-dependent transcription termination NP_874626.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_874629.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_874634.1 conserved in cyanobaceria NP_874637.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_874640.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_874642.1 conserved in cyanobaceria, similar to chloroplast CP12 protein NP_874645.1 catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate NP_874647.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_874653.1 conserved in cyanobacteria NP_874655.1 conserved in cyanobacteria NP_874656.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_874659.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_874662.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme NP_874663.1 conserved in cyanobacteria NP_874664.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_874665.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_874667.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor NP_874668.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis NP_874671.1 NtcA; cAMP-binding protein, HTH domain containing global regulator NP_874673.1 involved in recombination NP_874674.1 conserved in cyanobacteria NP_874675.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_874677.1 may be involved in regulating PSII assembly and/or stability NP_874679.1 4.8-kDa protein; may be involved in assembling and stabilizing of PSII dimers NP_874680.1 conserved in cyanobacteria NP_874682.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate NP_874684.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_874685.1 conserved in cyanobacteria NP_874686.1 conserved in cyanobacteria NP_874687.1 virulence factor MviN homolog NP_874688.1 Regulatory factor involved in maltose metabolism NP_874689.1 NtcA consensus at -88/-101, same start as in other Proc bu 40aa more in N-term than in other cyanos NP_874690.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway NP_874692.1 involved in de novo purine biosynthesis NP_874694.1 conserved in cyanobacteria NP_874697.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_874698.1 may be involved in binding plastoquinone and maintaining PSII dimers NP_874701.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_874705.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine NP_874707.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis NP_874708.1 NADH-dependent; catalyzes a key regulatory step in fatty acid biosynthesis NP_874717.1 catalyzes the transfer of electrons from NADH to quinones NP_874718.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen NP_874719.1 Catalyzes the transfer of electrons from NADH to quinone NP_874721.1 similar to Arabidopsis thaliana photosystem II assembly protein NP_874722.1 photosystem II reaction center subunit VI; associated with the reaction center of photosystem II NP_874723.1 photosystem II reaction center subunit VI; associated with the reaction center of photosystem II NP_874724.1 may have a role in PSII core assembly, maintaining PSII dimers and donor side electron transfer NP_874725.1 may be involved in assembling and maintaining PSII complexes in the thylakoid membrane NP_874734.1 HEAT-repeats NP_874735.1 HEAT-repeats NP_874736.1 contains phycoerythrin linker-proteins region NP_874737.1 contains phycoerythrin linker-proteins region NP_874743.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_874745.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_874747.1 Ycf8; may be involved in the formation and/or stabilization of PSII system complexes NP_874753.1 HemK family; It is in one operon with SUA5, implicated in translation NP_874756.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell NP_874761.1 electron transport protein NP_874762.1 PetD, with cytochrome b6, cytochrome F, and the Rieske protein, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_874764.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_874765.1 Stabilizes the interaction between PsaC and the photosystem I core NP_874766.1 conserved in cyanobacteria NP_874776.1 Distict subfamily NP_874778.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis NP_874781.1 conserved in cyanobacteria NP_874782.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_874784.1 conserved in cyanobacteria NP_874792.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein NP_874794.1 BS_ylqD homolog NP_874795.1 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA NP_874796.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_874802.1 conserved in cyanobacteria NP_874803.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_874806.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_874812.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate NP_874813.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_874818.1 chlorophyll a synthase; ChlG NP_874819.1 conserved in cyanobacteria NP_874820.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase NP_874821.1 involved in ubiquinone/menaquinone biosynthesis NP_874825.1 transfers electrons from NAD(P)H to quinons in the respiratory chain NP_874826.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_874830.1 unknown transporter NP_874832.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_874837.1 required for cytochrome oxidase assembly NP_874838.1 converts protoheme IX and farnesyl diphosphate to heme O NP_874842.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth NP_874845.1 conserved in cyanobacteria NP_874847.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_874848.1 similar to microcin C7 resistance protein MccF NP_874849.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin NP_874852.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_874853.1 cytochrome f, with cytochrome b6, subunit IV, and the Rieske protein, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_874854.1 Rieske protein, with cytochrome b6, cytochrome f, and subunit IV, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_874857.1 similar to eukaryotic snRNP NP_874858.1 Essential for recycling GMP and indirectly, cGMP NP_874859.1 Enables the organization of the psaE and psaF subunits NP_874861.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_874862.1 HLIP NP_874864.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_874866.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_874868.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential NP_874871.1 containing SMF/DprA family nucleotide binding domain fused to metal-binding center NP_874872.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription NP_874874.1 stomatin/prohibitin homolog NP_874875.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway NP_874878.1 conserved in cyanobacteria NP_874887.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_874888.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria NP_874891.1 conserved in cyanobacteria, contains TPR repeats NP_874892.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate NP_874893.1 conserved in cyanobacteria NP_874897.1 involved in tolerance to divalent cations NP_874899.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_874901.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_874904.1 glutaredoxin family NP_874905.1 conserved in cyanobacteria NP_874912.1 Maintains the balance of metabolites in the pentose-phosphate pathway NP_874914.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_874915.1 Catalyzes the phosphorylation of UMP to UDP NP_874918.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_874919.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit NP_874922.1 conserved in cyanobacteria NP_874925.1 conserved in cyanobacteria NP_874927.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein NP_874929.1 conserved in cyanobacteria; similar to N-terminal part of GTP cyclohydrolase I (Pro0537) in other marine cyanobacteria genomes, possible frameshift in SS120 NP_874936.1 Converts chlorophyllide a into protochlorophyllide; light dependent NP_874937.1 light-independent; with chlN(bchN) and chlB(bchB) reduces ring D of protochlorophyllide to form chlorophyllide a in chlorophyll/bacteriochlorophyll production NP_874938.1 light-independent reduction of protochlorophyllide to form chlorophyllide a NP_874939.1 light-independent reduction of protochlorophyllide to form chlorophyllide a NP_874940.1 conserved in cyanobacteria NP_874941.1 conserved in cyanobacteria NP_874944.1 type III RuBisCO; involved in carbon fixation NP_874945.1 RbcS NP_874951.1 function in cyanobacteria is unknown NP_874953.1 yjgF family NP_874955.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ NP_874960.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_874964.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_874966.1 conserved in cyanobacteria NP_874967.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_874968.1 Contains a conserved domain in cyanobacteria. Same domain in Pro0615, Pro0616, Pro1459 NP_874969.1 unknown function; YciI from Haemophilus influenzae has a crystal structure similar to a muconolactone isomerase, but does not seem to catalyze any of the reactions predicted from the sequence or structure similarity NP_874975.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis NP_874978.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine NP_874979.1 component of photosystem II; manganese-binding polypeptide with arginine metablolizing activity NP_874983.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_874989.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_874999.1 probably involved in mRNA decay, RNT1 homolog; Apparent HG, not found in other cyanos NP_875007.1 contains a conserved domain in cyanobacteria. Same domain in Pro0575, Pro0618, Pro01459 NP_875008.1 contains a conserved domain in cyanobacteria. Same domain in Pro0575, Pro0615, Pro01459 NP_875018.1 Fragment of Inositol polyphosphate phosphatase NP_875020.1 BS_yeeC ortholog; apparent HGT NP_875021.1 apparent HGT NP_875050.1 distantly similar to phage protein ECs0802 NP_875061.1 conserved in cyanobacteria NP_875064.1 conserved in cyanobacteria NP_875088.1 Present in some viral and phage genomes NP_875091.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_875092.1 catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone NP_875094.1 involved in DNA repair NP_875099.1 Possible independent HGT to Nostoc NP_875112.1 predicted permease NP_875113.1 COG3330 NP_875114.1 conserved in cyanobacteria NP_875121.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate NP_875123.1 conserved in cyanobacteria NP_875124.1 Present in some viral genomes NP_875127.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell NP_875129.1 major outer membrane protein, SLH domain NP_875133.1 conserved in cyanobacteria NP_875135.1 conserved in cyanobacteria NP_875136.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_875137.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_875138.1 antagonist of anti-sigma factor NP_875141.1 conserved in cyanobacteria NP_875142.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_875143.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase NP_875144.1 conserved in cyanobacteria NP_875145.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_875146.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_875148.1 Possibly HGT NP_875149.1 synthesizes RNA primers at the replication forks NP_875151.1 involved in DNA repair (SOS pathway) NP_875152.1 Distict subfamily NP_875155.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_875156.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis NP_875157.1 conserved in cyanobacteria NP_875159.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane NP_875160.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF NP_875162.1 predicted permease NP_875163.1 PsbW; part of the phosystem II reaction center NP_875164.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA NP_875165.1 conserved in cyanobacteria; Also present in plants, domain may be involved in signal transduction, see GI:17232441 NP_875166.1 Ser/Thr protein kinase NP_875167.1 conserved in cyanobacteria NP_875169.1 3'-5' exonuclease; Distict subfamily NP_875171.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_875173.1 conserved in cyanobacteria NP_875178.1 contains glutaredoxin-like domain; Distict subfamily NP_875179.1 Present in some viral and phage genomes NP_875185.1 Possibly independent HGT NP_875188.1 histidine acid phosphatase family NP_875197.1 Distict subfamily NP_875199.1 conserved in cyanobacteria NP_875211.1 catalyzes the reduction of biliverdin IX-alpha producing (3Z)-phycocyanobilin and oxidized ferredoxin NP_875215.1 conserved in cyanobacteria NP_875217.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_875218.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_875219.1 conserved in cyanobacteria NP_875220.1 catalyzes branch migration in Holliday junction intermediates NP_875222.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide NP_875226.1 involved in stress response NP_875228.1 possible cytochrome c biogenesis NP_875229.1 possible cytochrome c biogenesis NP_875232.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese NP_875233.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_875234.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate NP_875235.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_875238.1 conserved in cyanobacteria NP_875239.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_875240.1 conserved in cyanobacteria NP_875246.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis NP_875247.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis NP_875251.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_875256.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis NP_875258.1 conserved in cyanobacteria NP_875259.1 involved in recombination NP_875260.1 conserved in cyanobacteria, contains N-terminal GNAT family acetyltransferase domain NP_875261.1 related to COG4071/COG1478 NP_875262.1 inactivated NP_875268.1 conserved in cyanobacteria NP_875269.1 GNAT family NP_875270.1 conserved in cyanobacteria; Also present in plants as a domain NP_875276.1 fused to possible metal-binding cluster NP_875278.1 conserved in cyanobacteria NP_875286.1 conserved in cyanobacteria NP_875288.1 conserved in cyanobacteria NP_875289.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_875293.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_875295.1 catalyzes the formation of Mg-protoporphyrin IX from protoporphyrin IX and Mg(2+); first committed step of chlorophyll biosynthesis NP_875296.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_875297.1 conserved in cyanobacteria NP_875299.1 conserved in cyanobacteria NP_875300.1 conserved in cyanobacteria NP_875301.1 conserved in cyanobacteria NP_875303.1 conserved in cyanobacteria NP_875309.1 conserved in cyanobacteria NP_875310.1 subunit VIII; plays a crucial role in complex assembly and/or stability; with PetL, PetG and PetM makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_875311.1 Psb29; involved in biogenesis of the photosystem II; in Arabidopsis it interacts with the heterotrimeric G-protein (GPA1) and seems to be involved in a D-glucose signaling mechanism between plastid and the plasma membranes NP_875312.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; in Synechococcus this protein (ClpP1)is constitutive and levels increased with the increase of light. NP_875315.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_875316.1 Distict subfamily NP_875319.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway NP_875320.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_875325.2 required for 70S ribosome assembly NP_875326.1 molecular chaperone NP_875328.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine NP_875330.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_875332.1 conserved in cyanobacteria NP_875333.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway NP_875334.1 cyclophilin family NP_875335.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; note this protein has an additional C-terminal tail of unknown function as compared to similar bifunctional enzymes NP_875336.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate NP_875338.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_875340.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate NP_875342.1 conserved in cyanobacteria NP_875343.1 penicillin-binding protein 4 NP_875345.1 associated with flavoprotein oxygenases NP_875346.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_875350.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_875353.1 5',5'''-P-1,P-4-tetraphosphate phosphorylase II NP_875358.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_875359.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_875360.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_875362.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_875364.1 conserved in cyanobacteria NP_875367.1 SpoU class NP_875368.1 apparent HGT NP_875373.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_875374.1 conserved in cyanobacteria NP_875380.1 protein conferring resistance to acetazolamide NP_875381.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate NP_875383.1 conserved in cyanobacteria NP_875384.1 oxidative; catalyzes the formation of divinylprotochlorophyllide from magnesium-protoporphyrin IX 13-monomethyl ester in isocyclic ring formation in chlorophyll biosynthesis NP_875387.1 TldD NP_875388.1 PmbA NP_875390.1 possibly involved in tellurium resistance NP_875391.1 conserved in cyanobacteria NP_875392.1 superfamily II helicase NP_875396.1 conserved in cyanobacteria NP_875397.1 conserved in cyanobacteria NP_875398.1 conserved in cyanobacteria NP_875399.1 conserved in cyanobacteria NP_875400.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_875403.1 conserved in cyanobacteria NP_875404.1 calcineurin family NP_875405.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate NP_875407.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis NP_875412.1 translationally coupled to PhnD NP_875414.1 Translationally coupled to PhnC related to c-p lyase NP_875416.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_875417.1 conserved in cyanobacteria NP_875419.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_875421.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein NP_875422.1 conserved in cyanobacteria NP_875426.1 conserved in cyanobacteria NP_875427.1 PLP dependent; Rhizobactin siderophore biosynthesis NP_875438.1 catalyzes the formation of (2R)-3-sulfolactate from (2R)-2-phospho-3-sulfolactate NP_875440.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_875442.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_875444.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose NP_875445.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA NP_875448.1 conserved in cyanobacteria NP_875449.1 specific for cyanobacteria NP_875455.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_875456.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_875458.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_875459.1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunit D, with NdhB and NdhF are core membrane components NP_875463.1 catalyzes the reduction of L-gamma-glutamyl 5-phosphate to form L-glutamate 5-semialdehyde in proline biosynthesis NP_875465.1 Close homologs in plants NP_875466.1 conserved in cyanobacteria NP_875470.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain NP_875471.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_875473.1 participates in electron transfer in photosystem I NP_875475.1 CheY-like receiver domain and a wHTH DNA-binding domain; OmpR homolog; OmpR homolog; OmpR subfamily/phoB NP_875476.1 conserved in cyanobacteria NP_875479.1 conserved in cyanobacteria NP_875481.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) NP_875484.1 exonuclease V; contains helicase and exonuclease domains NP_875485.1 exonuclease V; helicase superfamily I member NP_875487.1 Metal-binding motif NP_875490.1 RecF pathway NP_875491.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_875492.1 conserved in cyanobacteria; Also present in plants as a domain NP_875495.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_875502.1 conserved in cyanobacteria NP_875507.1 conserved in bacteria NP_875508.1 amylomaltase; acts to release glucose from maltodextrins NP_875510.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_875513.1 interacts with the circadian clock regulator KaiC to maintain circadian rhythms NP_875514.1 Related to COG2867 NP_875516.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_875519.1 Distinct subfamily NP_875526.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis NP_875529.1 negatively supercoils closed circular double-stranded DNA NP_875530.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_875532.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide NP_875534.1 cytochrome b6-f complex subunit 5; plastohydroquinone/plastocyanin oxidoreductase; with PetL, PetM and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_875539.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity NP_875541.1 may be involved in Fe-S center assembly NP_875542.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_875547.1 Distict subfamily NP_875548.1 conserved in cyanobacteria NP_875556.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_875567.1 HLIP NP_875568.1 HLIP NP_875573.1 conserved in cyanobacteria NP_875576.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis NP_875583.1 Probably domain present in isoamylase of plants NP_875624.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_875626.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair NP_875627.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_875628.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_875641.1 Ycf31; cytochrome b6-f complex subunit 7; with PetL, PetG and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I NP_875643.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit NP_875644.1 cyclophilin family NP_875645.1 required for the assembly of photosystem I complex NP_875649.1 conserved in cyanobacteria NP_875650.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation NP_875653.1 Distict subfamily NP_875655.1 apparent HGT NP_875657.1 Present in eukaryotes. Fused to SPX domain and involved in phosphate metabolism, distinct subfamily NP_875659.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_875660.1 major outer membrane protein, SLH domain NP_875664.1 Present in other nostoc NP_875665.1 predicted restriction/modification system component; ortholog of BS_yeeB; apparent HGT NP_875669.1 apparent HGT NP_875670.1 apparent HGT NP_875674.1 apparent HGT, probably COG5285 member NP_875675.1 apparent HGT NP_875682.1 apparent HGT NP_875689.1 conserved in cyanobacteria NP_875690.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_875692.1 conserved in cyanobacteria NP_875693.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_875695.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_875696.1 S2P family NP_875697.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_875699.1 CysQ/AmtA; PAPS NP_875702.1 conserved in cyanobacteria, contains N-terminal HTH domain; HTH containing, possible regulatory protein NP_875707.1 involved in polysaccharide export NP_875713.1 bifunctional sugar kinase/adenylyltransferase NP_875715.1 apparent HGT NP_875721.1 involved in exopolysaccharide biosynthesis NP_875726.1 conserved in cyanobacteria NP_875727.1 RecA-mediated autopeptidase NP_875730.1 riboflavin biosynthesis NP_875731.1 conserved in cyanobacteria NP_875734.1 catalyzes the phosphorylation of NAD to NADP NP_875735.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_875736.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate NP_875737.1 conserved in cyanobacteria NP_875739.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate NP_875740.1 involved in thiamine biosynthesis; ThiS family NP_875743.1 PurE related protein NP_875744.1 conserved in cyanobacteria NP_875746.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_875747.1 conserved in cyanobacteria NP_875748.1 interacts with FtsH NP_875749.1 predicted ATPase NP_875750.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_875752.1 contains DnaJ domain; PM: 12218043, also present in plants NP_875755.1 YyjeF family; also a domain in COG0063 NP_875756.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_875759.1 apparent HGT, PM:96433106 NP_875761.1 May facilitate nickel incorporation, present in many plants NP_875762.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water NP_875763.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide NP_875765.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_875766.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine NP_875770.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) NP_875772.1 conserved in cyanobacteria NP_875774.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_875775.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate NP_875778.1 ClpR variant present in an operon with ClpP3 in Synechococcus PCC7942; ClpR is missing the catalytic triad Ser-His-Asp characteristic of serine-type proteases; the exact function of ClpR and ClpP3 is unknown however they appear to be necessary for cell viability; hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_875779.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_875780.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_875782.1 involved in lipopolysaccharide synthesis NP_875786.1 HLIP NP_875797.1 conserved in cyanobacteria NP_875798.1 conserved in cyanobacteria NP_875801.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_875802.1 conserved in cyanobacteria NP_875804.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides NP_875806.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM NP_875807.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis NP_875808.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_875809.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis NP_875811.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_875812.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_875813.1 similar to NblS protein; contains HAMP; PAS and histidine kinase domains NP_875814.1 acts as a promotor non-specific transcription repressor NP_875815.1 Decreases the phosphorylation of KaiC, a component of the main circadian regulator in cyanobacteria NP_875817.1 involved in the peptidyltransferase reaction during translation NP_875824.1 conserved in cyanobacteria NP_875826.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_875827.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate NP_875830.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_875836.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_875844.1 apparent HGT, may be distant YciI homolog NP_875850.1 contains a conserved domain in cyanobacteria. Same domain in Pro0575, Pro0615, Pro01459 NP_875856.1 CxxC motif NP_875858.1 conserved in cyanobacteria NP_875885.1 photosystem II reaction center subunit VI; associated with the reaction center of photosystem II NP_875889.1 conserved in cyanobacteria NP_875902.1 has a prokaryotic membrane lipoprotein lipid attachment site NP_875903.1 HLIP NP_875904.1 HLIP NP_875905.1 HLIP NP_875907.1 HLIP NP_875919.1 HLIP NP_875927.1 Distict subfamily NP_875934.1 Distict subfamily NP_875936.1 apparent HGT NP_875937.1 conserved in cyanobacteria NP_875938.1 apparent HGT NP_875943.1 regulator of disulfide bond formation; OsmC family NP_875946.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA NP_875949.1 double stranded beta helix domain NP_875954.1 apparent HGT NP_875957.1 HLIP NP_875969.1 ArsR family NP_875973.1 conserved in cyanobacteria NP_875974.1 conserved in cyanobacteria NP_875975.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_875977.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_875978.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate NP_875980.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_875981.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_875982.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_875983.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_875984.1 conserved in cyanobacteria, ycf65; Claimed to be a component of chloroplast ribosomal 30S subunit (GI:7578871) NP_875989.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria NP_875992.1 conserved in cyanobacteria, possible subunit of ATP synthase NP_875993.1 conserved in cyanobacteria, possible subunit of ATP synthase NP_875994.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_875995.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_875996.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_875997.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel. NP_875998.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_875999.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 NP_876000.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_876001.1 conserved in cyanobacteria, possible subunit of ATP synthase NP_876010.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_876011.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_876015.1 Distict subfamily NP_876018.1 conserved in cyanobacteria NP_876020.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_876021.1 aldo/keto reductase family NP_876023.1 conserved in cyanobacteria; Present in many chloroplasts NP_876024.1 conserved in cyanobacteria NP_876025.1 possible phycoerythrobilin lyase subunit NP_876027.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_876028.1 HLIP NP_876029.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_876030.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates NP_876031.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_876033.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_876034.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer NP_876035.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_876036.1 periplasmic; contains C-terminal PDZ domain NP_876038.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_876040.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_876041.1 conserved in cyanobacteria NP_876043.1 specific for cyanobacteria; probably similar to Mg-protoporphyrin oxidative cyclase NP_876044.1 CAAX family NP_876045.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA NP_876046.1 catalyzes the interconversion of tetrahydrodipicolinate and L,L-diaminopimelate in lysine biosynthesis NP_876049.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_876050.1 conserved in cyanobacteria NP_876053.1 similar to the N-terminal domain of Lon protease NP_876054.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_876055.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_876056.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_876057.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_876058.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_876061.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_876063.1 with PsaB binds the primary electron donor of photosystem I, P700, and subsequent electron acceptors as part of photosystem I NP_876064.1 with PsaA binds the primary electron donor of photosystem I, P700, and subsequent electron acceptors as part of photosystem I NP_876066.1 NLP/P60 family NP_876072.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer NP_876074.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_876075.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_876076.1 forms a direct contact with the tRNA during translation NP_876077.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_876078.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_876079.1 is a component of the macrolide binding site in the peptidyl transferase center NP_876080.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_876081.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_876082.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_876083.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_876085.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_876086.1 late assembly protein NP_876087.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_876088.1 binds 5S rRNA along with protein L5 and L25 NP_876089.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_876090.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_876091.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_876092.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_876093.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_876096.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_876097.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_876098.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_876099.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_876100.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_876101.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_876102.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_876103.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_876104.1 conserved in cyanobacteria NP_876105.1 involved in light-dependent modulation of the circadian period (GI:22901052) NP_876107.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_876108.1 conserved in cyanobacteria NP_876110.1 catalyzes the formation of tyrosine from arogenate NP_876115.1 involved in molybdopterin and thiamine biosynthesis NP_876116.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide NP_876118.1 Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine NP_876119.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_876121.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate NP_876127.1 involved in chromosome partitioning NP_876128.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis NP_876130.1 conserved in cyanobacteria NP_876132.1 specific for cyanobacteria NP_876136.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_876137.1 catalyzes the formation of pantothenate from pantoate and beta-alanine and the formation of cytidine diphosphate from cytidine monophosphate NP_876139.1 catalyzes the reduction of 15,16-dihydrobiliverdin to (3Z)-phycoerythrobilin NP_876140.2 catalyzes the reduction of biliverdin IX-alpha to 15,16-dihydrobiliverdin NP_876142.1 conserved in cyanobacteria NP_876143.1 Converts isocitrate to alpha ketoglutarate NP_876145.1 apparent HGT NP_876146.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent NP_876149.1 also COG1226 NP_876154.1 conserved in cyanobacteria NP_876155.1 Essential for efficient processing of 16S rRNA NP_876157.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_876158.1 part of the core of the reaction center of photosystem I NP_876159.1 carries the fatty acid chain in fatty acid biosynthesis NP_876161.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_876162.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine NP_876166.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_876167.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_876170.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_876171.1 CheY-like receiver domain and a wHTH DNA-binding domain NP_876172.1 mreD; Maybe COG2891 NP_876173.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_876174.1 functions in MreBCD complex in some organisms NP_876175.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_876177.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine NP_876181.1 alpha/beta hydrolase superfamily NP_876184.1 possibly involved in chromosome condensation; CrcB family NP_876185.1 possibly involved in chromosome condensation; CrcB family NP_876187.1 negatively supercoils closed circular double-stranded DNA NP_876188.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_876189.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_876192.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_876193.1 GNAT family NP_876194.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_876195.1 similar to chloroplast protein ycf9 NP_876196.1 This protein performs the mismatch recognition step during the DNA repair process NP_876198.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA NP_876199.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP NP_876200.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_876204.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_876206.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_876208.1 binds and unfolds substrates as part of the ClpXP protease NP_876213.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_876214.1 involved in photosystem I assembly, ycf3 chloroplast protein homolog NP_876215.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate NP_876220.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine NP_876221.1 lipoate-binding NP_876222.1 involved in aluminum resistance NP_876225.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_876227.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_876228.1 Present in many chloroplasts NP_876230.1 Only eukar. Homologs NP_876232.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_876235.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_876238.1 MazG family NP_876239.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine NP_876242.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein NP_876243.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_876244.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_876253.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate NP_876254.1 sigma70/sigma32 NP_876256.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive NP_876257.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate NP_876260.1 EXOQ family NP_876262.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_876264.1 conserved in cyanobacteria; Also present in plants (chloroplasts) NP_876265.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_876266.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming NP_876268.1 specific for cyanobacteria NP_876269.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_876272.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_876273.1 involved in DNA repair, RecN NP_876275.1 conserved in cyanobacteria NP_876276.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine