-- dump date 20120504_155031 -- class Genbank::misc_feature -- table misc_feature_note -- id note 167539000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 167539000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 167539000003 putative DNA binding surface [nucleotide binding]; other site 167539000004 dimer interface [polypeptide binding]; other site 167539000005 beta-clamp/clamp loader binding surface; other site 167539000006 beta-clamp/translesion DNA polymerase binding surface; other site 167539000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 167539000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 167539000009 dimerization interface [polypeptide binding]; other site 167539000010 ATP binding site [chemical binding]; other site 167539000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 167539000012 dimerization interface [polypeptide binding]; other site 167539000013 ATP binding site [chemical binding]; other site 167539000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 167539000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 167539000016 active site 167539000017 tetramer interface [polypeptide binding]; other site 167539000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539000019 active site 167539000020 DNA gyrase, A subunit; Region: gyrA; TIGR01063 167539000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 167539000022 CAP-like domain; other site 167539000023 active site 167539000024 primary dimer interface [polypeptide binding]; other site 167539000025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539000026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000027 TPR motif; other site 167539000028 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167539000029 binding surface 167539000030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000031 binding surface 167539000032 TPR motif; other site 167539000033 TPR repeat; Region: TPR_11; pfam13414 167539000034 TPR repeat; Region: TPR_11; pfam13414 167539000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 167539000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 167539000037 4Fe-4S binding domain; Region: Fer4; cl02805 167539000038 Protein of unknown function (DUF502); Region: DUF502; cl01107 167539000039 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 167539000040 putative RNA binding site [nucleotide binding]; other site 167539000041 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 167539000042 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 167539000043 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167539000044 P loop; other site 167539000045 GTP binding site [chemical binding]; other site 167539000046 GAF domain; Region: GAF; cl15785 167539000047 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 167539000048 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 167539000049 argininosuccinate lyase; Provisional; Region: PRK00855 167539000050 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 167539000051 active sites [active] 167539000052 tetramer interface [polypeptide binding]; other site 167539000053 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 167539000054 RNA/DNA binding site [nucleotide binding]; other site 167539000055 RRM dimerization site [polypeptide binding]; other site 167539000056 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 167539000057 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167539000058 FMN binding site [chemical binding]; other site 167539000059 active site 167539000060 catalytic residues [active] 167539000061 substrate binding site [chemical binding]; other site 167539000062 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 167539000063 SelR domain; Region: SelR; pfam01641 167539000064 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 167539000065 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 167539000066 dimer interface [polypeptide binding]; other site 167539000067 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 167539000068 chaperone protein DnaJ; Provisional; Region: PRK14293 167539000069 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539000070 HSP70 interaction site [polypeptide binding]; other site 167539000071 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 167539000072 substrate binding site [polypeptide binding]; other site 167539000073 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 167539000074 Zn binding sites [ion binding]; other site 167539000075 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167539000076 dimer interface [polypeptide binding]; other site 167539000077 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 167539000078 CPxP motif; other site 167539000079 Predicted GTPases [General function prediction only]; Region: COG1162 167539000080 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539000081 RNA binding site [nucleotide binding]; other site 167539000082 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 167539000083 GTPase/Zn-binding domain interface [polypeptide binding]; other site 167539000084 GTP/Mg2+ binding site [chemical binding]; other site 167539000085 G4 box; other site 167539000086 G5 box; other site 167539000087 G1 box; other site 167539000088 Switch I region; other site 167539000089 G2 box; other site 167539000090 G3 box; other site 167539000091 Switch II region; other site 167539000092 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 167539000093 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 167539000094 FAD binding domain; Region: FAD_binding_4; pfam01565 167539000095 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 167539000096 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 167539000097 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167539000098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539000099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539000100 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 167539000101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000102 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 167539000103 thiamine monophosphate kinase; Provisional; Region: PRK05731 167539000104 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 167539000105 ATP binding site [chemical binding]; other site 167539000106 dimerization interface [polypeptide binding]; other site 167539000107 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 167539000108 active site 167539000109 elongation factor P; Validated; Region: PRK00529 167539000110 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 167539000111 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 167539000112 RNA binding site [nucleotide binding]; other site 167539000113 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 167539000114 RNA binding site [nucleotide binding]; other site 167539000115 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 167539000116 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 167539000117 carboxyltransferase (CT) interaction site; other site 167539000118 biotinylation site [posttranslational modification]; other site 167539000119 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 167539000120 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 167539000121 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539000122 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 167539000123 putative NAD(P) binding site [chemical binding]; other site 167539000124 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167539000125 active site 167539000126 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 167539000127 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167539000128 homodimer interface [polypeptide binding]; other site 167539000129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000130 catalytic residue [active] 167539000131 CbiD; Region: CbiD; cl00828 167539000132 GMP synthase; Reviewed; Region: guaA; PRK00074 167539000133 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 167539000134 AMP/PPi binding site [chemical binding]; other site 167539000135 candidate oxyanion hole; other site 167539000136 catalytic triad [active] 167539000137 potential glutamine specificity residues [chemical binding]; other site 167539000138 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 167539000139 ATP Binding subdomain [chemical binding]; other site 167539000140 Ligand Binding sites [chemical binding]; other site 167539000141 Dimerization subdomain; other site 167539000142 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 167539000143 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167539000144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539000145 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167539000146 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167539000147 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167539000148 Flavin Reductases; Region: FlaRed; cl00801 167539000149 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167539000150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539000151 Flavin Reductases; Region: FlaRed; cl00801 167539000152 SWIM zinc finger; Region: SWIM; cl15408 167539000153 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 167539000154 SNF2 Helicase protein; Region: DUF3670; pfam12419 167539000155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539000156 ATP binding site [chemical binding]; other site 167539000157 putative Mg++ binding site [ion binding]; other site 167539000158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539000159 nucleotide binding region [chemical binding]; other site 167539000160 ATP-binding site [chemical binding]; other site 167539000161 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 167539000162 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 167539000163 motif 1; other site 167539000164 active site 167539000165 motif 2; other site 167539000166 motif 3; other site 167539000167 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 167539000168 DHHA1 domain; Region: DHHA1; pfam02272 167539000169 arginine decarboxylase; Provisional; Region: PRK05354 167539000170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 167539000171 dimer interface [polypeptide binding]; other site 167539000172 active site 167539000173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539000174 catalytic residues [active] 167539000175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167539000176 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 167539000177 active site 167539000178 multimer interface [polypeptide binding]; other site 167539000179 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 167539000180 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 167539000181 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 167539000182 GatB domain; Region: GatB_Yqey; cl11497 167539000183 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 167539000184 dephospho-CoA kinase; Region: TIGR00152 167539000185 CoA-binding site [chemical binding]; other site 167539000186 ATP-binding [chemical binding]; other site 167539000187 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 167539000188 heterotetramer interface [polypeptide binding]; other site 167539000189 active site pocket [active] 167539000190 cleavage site 167539000191 HupE / UreJ protein; Region: HupE_UreJ; cl01011 167539000192 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167539000193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539000194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000195 Walker A/P-loop; other site 167539000196 ATP binding site [chemical binding]; other site 167539000197 Q-loop/lid; other site 167539000198 ABC transporter signature motif; other site 167539000199 Walker B; other site 167539000200 D-loop; other site 167539000201 H-loop/switch region; other site 167539000202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539000203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 167539000204 putative homodimer interface [polypeptide binding]; other site 167539000205 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 167539000206 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 167539000207 active site 167539000208 dimer interface [polypeptide binding]; other site 167539000209 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 167539000210 Ligand Binding Site [chemical binding]; other site 167539000211 Molecular Tunnel; other site 167539000212 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167539000213 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 167539000214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000215 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 167539000216 Ligand binding site; other site 167539000217 Putative Catalytic site; other site 167539000218 DXD motif; other site 167539000219 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 167539000220 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 167539000221 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 167539000222 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167539000223 NADP-binding site; other site 167539000224 homotetramer interface [polypeptide binding]; other site 167539000225 substrate binding site [chemical binding]; other site 167539000226 homodimer interface [polypeptide binding]; other site 167539000227 active site 167539000228 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 167539000229 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 167539000230 NADP binding site [chemical binding]; other site 167539000231 active site 167539000232 putative substrate binding site [chemical binding]; other site 167539000233 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 167539000234 THUMP domain; Region: THUMP; cl12076 167539000235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000236 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 167539000237 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 167539000238 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 167539000239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000240 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 167539000241 Walker A/P-loop; other site 167539000242 ATP binding site [chemical binding]; other site 167539000243 Q-loop/lid; other site 167539000244 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 167539000245 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 167539000246 Q-loop/lid; other site 167539000247 ABC transporter signature motif; other site 167539000248 Walker B; other site 167539000249 D-loop; other site 167539000250 H-loop/switch region; other site 167539000251 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 167539000252 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 167539000253 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 167539000254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167539000255 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539000256 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 167539000257 YGGT family; Region: YGGT; cl00508 167539000258 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 167539000259 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167539000260 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 167539000261 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167539000262 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 167539000263 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 167539000264 nucleotide binding site/active site [active] 167539000265 HIT family signature motif; other site 167539000266 catalytic residue [active] 167539000267 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 167539000268 active site 167539000269 catalytic residues [active] 167539000270 metal binding site [ion binding]; metal-binding site 167539000271 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 167539000272 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167539000273 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167539000274 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 167539000275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539000276 catalytic residue [active] 167539000277 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 167539000278 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 167539000279 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 167539000280 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 167539000281 Walker A/P-loop; other site 167539000282 ATP binding site [chemical binding]; other site 167539000283 Q-loop/lid; other site 167539000284 ABC transporter signature motif; other site 167539000285 Walker B; other site 167539000286 D-loop; other site 167539000287 H-loop/switch region; other site 167539000288 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 167539000289 putative ABC transporter; Region: ycf24; CHL00085 167539000290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167539000291 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 167539000292 phosphoglucomutase; Region: PLN02307 167539000293 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 167539000294 active site 167539000295 substrate binding site [chemical binding]; other site 167539000296 metal binding site [ion binding]; metal-binding site 167539000297 recombination factor protein RarA; Reviewed; Region: PRK13342 167539000298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000299 Walker A motif; other site 167539000300 ATP binding site [chemical binding]; other site 167539000301 Walker B motif; other site 167539000302 arginine finger; other site 167539000303 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 167539000304 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 167539000305 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 167539000306 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167539000307 catalytic triad [active] 167539000308 Type III pantothenate kinase; Region: Pan_kinase; cl09130 167539000309 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 167539000310 Active Sites [active] 167539000311 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 167539000312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539000313 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167539000314 transmembrane helices; other site 167539000315 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167539000316 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167539000317 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167539000318 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 167539000319 Cation transport protein; Region: TrkH; cl10514 167539000320 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167539000321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000322 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 167539000323 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167539000324 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167539000325 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167539000326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000327 Walker A/P-loop; other site 167539000328 ATP binding site [chemical binding]; other site 167539000329 Q-loop/lid; other site 167539000330 ABC transporter signature motif; other site 167539000331 Walker B; other site 167539000332 D-loop; other site 167539000333 H-loop/switch region; other site 167539000334 ABC transporter; Region: ABC_tran_2; pfam12848 167539000335 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 167539000336 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167539000337 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 167539000338 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167539000339 protein binding site [polypeptide binding]; other site 167539000340 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 167539000341 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167539000342 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 167539000343 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 167539000344 generic binding surface II; other site 167539000345 generic binding surface I; other site 167539000346 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 167539000347 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 167539000348 RecR protein; Region: RecR; pfam02132 167539000349 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 167539000350 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 167539000351 active site 167539000352 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 167539000353 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 167539000354 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 167539000355 Protein of unknown function (DUF512); Region: DUF512; pfam04459 167539000356 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 167539000357 L-aspartate oxidase; Provisional; Region: PRK07395 167539000358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000359 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167539000360 Vitamin K epoxide reductase family; Region: VKOR; cl01729 167539000361 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539000362 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 167539000363 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167539000364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539000365 FeS/SAM binding site; other site 167539000366 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 167539000367 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 167539000368 Protein of unknown function, DUF482; Region: DUF482; pfam04339 167539000369 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 167539000370 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539000371 active site 167539000372 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539000373 active site 167539000374 shikimate kinase; Reviewed; Region: aroK; PRK00131 167539000375 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 167539000376 ADP binding site [chemical binding]; other site 167539000377 magnesium binding site [ion binding]; other site 167539000378 putative shikimate binding site; other site 167539000379 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 167539000380 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167539000381 C-terminal domain interface [polypeptide binding]; other site 167539000382 GSH binding site (G-site) [chemical binding]; other site 167539000383 dimer interface [polypeptide binding]; other site 167539000384 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167539000385 N-terminal domain interface [polypeptide binding]; other site 167539000386 dimer interface [polypeptide binding]; other site 167539000387 substrate binding pocket (H-site) [chemical binding]; other site 167539000388 Protein of unknown function (DUF751); Region: DUF751; pfam05421 167539000389 Ribosome-binding factor A; Region: RBFA; cl00542 167539000390 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 167539000391 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 167539000392 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 167539000393 active site 167539000394 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 167539000395 putative hydrophobic ligand binding site [chemical binding]; other site 167539000396 carotene 7,8-desaturase; Region: zeta_caro_desat; TIGR02732 167539000397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000398 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 167539000399 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167539000400 conserved hypothetical protein; Region: TIGR03492 167539000401 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 167539000402 TIGR01777 family protein; Region: yfcH 167539000403 putative NAD(P) binding site [chemical binding]; other site 167539000404 putative active site [active] 167539000405 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 167539000406 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 167539000407 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539000408 HSP70 interaction site [polypeptide binding]; other site 167539000409 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167539000410 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167539000411 dimer interface [polypeptide binding]; other site 167539000412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000413 catalytic residue [active] 167539000414 hypothetical protein; Provisional; Region: PRK13683 167539000415 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167539000416 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 167539000417 Walker A/P-loop; other site 167539000418 ATP binding site [chemical binding]; other site 167539000419 Q-loop/lid; other site 167539000420 ABC transporter signature motif; other site 167539000421 Walker B; other site 167539000422 D-loop; other site 167539000423 H-loop/switch region; other site 167539000424 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 167539000425 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 167539000426 Short C-terminal domain; Region: SHOCT; cl01373 167539000427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167539000428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539000429 active site 167539000430 phosphorylation site [posttranslational modification] 167539000431 intermolecular recognition site; other site 167539000432 dimerization interface [polypeptide binding]; other site 167539000433 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539000434 DNA binding site [nucleotide binding] 167539000435 DNA polymerase III subunit delta'; Validated; Region: PRK07399 167539000436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000437 thymidylate kinase; Validated; Region: tmk; PRK00698 167539000438 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 167539000439 TMP-binding site; other site 167539000440 ATP-binding site [chemical binding]; other site 167539000441 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 167539000442 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 167539000443 metal-binding site [ion binding] 167539000444 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 167539000445 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167539000446 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 167539000447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539000448 binding surface 167539000449 TPR motif; other site 167539000450 DNA repair protein RadA; Provisional; Region: PRK11823 167539000451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000452 Walker A motif; other site 167539000453 ATP binding site [chemical binding]; other site 167539000454 Walker B motif; other site 167539000455 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 167539000456 Ycf27; Reviewed; Region: orf27; CHL00148 167539000457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539000458 active site 167539000459 phosphorylation site [posttranslational modification] 167539000460 intermolecular recognition site; other site 167539000461 dimerization interface [polypeptide binding]; other site 167539000462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539000463 DNA binding site [nucleotide binding] 167539000464 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 167539000465 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 167539000466 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 167539000467 dimer interface [polypeptide binding]; other site 167539000468 active site 167539000469 CoA binding pocket [chemical binding]; other site 167539000470 Acyl transferase domain; Region: Acyl_transf_1; cl08282 167539000471 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 167539000472 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167539000473 putative acyl-acceptor binding pocket; other site 167539000474 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 167539000475 putative active site [active] 167539000476 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 167539000477 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167539000478 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167539000479 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167539000480 active site 167539000481 NTP binding site [chemical binding]; other site 167539000482 metal binding triad [ion binding]; metal-binding site 167539000483 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 167539000484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 167539000485 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 167539000486 RNA/DNA binding site [nucleotide binding]; other site 167539000487 RRM dimerization site [polypeptide binding]; other site 167539000488 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 167539000489 active site lid residues [active] 167539000490 substrate binding pocket [chemical binding]; other site 167539000491 catalytic residues [active] 167539000492 substrate-Mg2+ binding site; other site 167539000493 aspartate-rich region 1; other site 167539000494 aspartate-rich region 2; other site 167539000495 phytoene desaturase; Region: phytoene_desat; TIGR02731 167539000496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000497 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 167539000498 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 167539000499 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 167539000500 Helix-turn-helix domains; Region: HTH; cl00088 167539000501 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 167539000502 putative dimerization interface [polypeptide binding]; other site 167539000503 Phospholipid methyltransferase; Region: PEMT; cl00763 167539000504 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167539000505 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 167539000506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167539000507 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 167539000508 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 167539000509 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167539000510 ScpA/B protein; Region: ScpA_ScpB; cl00598 167539000511 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167539000512 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167539000513 active site 167539000514 Substrate binding site; other site 167539000515 Mg++ binding site; other site 167539000516 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 167539000517 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 167539000518 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 167539000519 FAD binding site [chemical binding]; other site 167539000520 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167539000521 DNA binding residues [nucleotide binding] 167539000522 dimerization interface [polypeptide binding]; other site 167539000523 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 167539000524 putative active site [active] 167539000525 putative metal binding residues [ion binding]; other site 167539000526 signature motif; other site 167539000527 putative dimer interface [polypeptide binding]; other site 167539000528 putative phosphate binding site [ion binding]; other site 167539000529 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 167539000530 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 167539000531 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 167539000532 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 167539000533 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 167539000534 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 167539000535 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167539000536 NADH dehydrogenase; Region: NADHdh; cl00469 167539000537 citrate synthase; Provisional; Region: PRK14036 167539000538 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 167539000539 oxalacetate binding site [chemical binding]; other site 167539000540 citrylCoA binding site [chemical binding]; other site 167539000541 coenzyme A binding site [chemical binding]; other site 167539000542 catalytic triad [active] 167539000543 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 167539000544 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 167539000545 active site residue [active] 167539000546 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 167539000547 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 167539000548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000549 catalytic residue [active] 167539000550 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 167539000551 Predicted RNA interaction site [nucleotide binding]; other site 167539000552 putative binding site; other site 167539000553 Mutations affecting start-site selection; other site 167539000554 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 167539000555 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 167539000556 ligand-binding site [chemical binding]; other site 167539000557 AIR carboxylase; Region: AIRC; cl00310 167539000558 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 167539000559 active site 167539000560 dimer interface [polypeptide binding]; other site 167539000561 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 167539000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539000563 S-adenosylmethionine binding site [chemical binding]; other site 167539000564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167539000566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539000567 active site 167539000568 phosphorylation site [posttranslational modification] 167539000569 intermolecular recognition site; other site 167539000570 dimerization interface [polypeptide binding]; other site 167539000571 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167539000572 DNA binding residues [nucleotide binding] 167539000573 dimerization interface [polypeptide binding]; other site 167539000574 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 167539000575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539000576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539000577 catalytic residue [active] 167539000578 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 167539000579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000580 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 167539000581 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 167539000582 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167539000583 active site 167539000584 AMP-binding enzyme; Region: AMP-binding; cl15778 167539000585 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 167539000586 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 167539000587 active site 167539000588 UbiA prenyltransferase family; Region: UbiA; cl00337 167539000589 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 167539000590 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167539000591 glutathione synthetase; Provisional; Region: PRK05246 167539000592 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 167539000593 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539000594 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 167539000595 GSH binding site [chemical binding]; other site 167539000596 catalytic residues [active] 167539000597 peptide chain release factor 2; Validated; Region: prfB; PRK00578 167539000598 RF-1 domain; Region: RF-1; cl02875 167539000599 RF-1 domain; Region: RF-1; cl02875 167539000600 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 167539000601 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 167539000602 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 167539000603 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 167539000604 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 167539000605 glutamine binding [chemical binding]; other site 167539000606 catalytic triad [active] 167539000607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539000608 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 167539000609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539000610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000611 homodimer interface [polypeptide binding]; other site 167539000612 catalytic residue [active] 167539000613 arginine-tRNA ligase; Region: PLN02286 167539000614 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 167539000615 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 167539000616 active site 167539000617 HIGH motif; other site 167539000618 KMSK motif region; other site 167539000619 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 167539000620 tRNA binding surface [nucleotide binding]; other site 167539000621 anticodon binding site; other site 167539000622 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 167539000623 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 167539000624 dimerization interface [polypeptide binding]; other site 167539000625 active site 167539000626 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 167539000627 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 167539000628 trmE is a tRNA modification GTPase; Region: trmE; cd04164 167539000629 G1 box; other site 167539000630 GTP/Mg2+ binding site [chemical binding]; other site 167539000631 Switch I region; other site 167539000632 G2 box; other site 167539000633 Switch II region; other site 167539000634 G3 box; other site 167539000635 G4 box; other site 167539000636 G5 box; other site 167539000637 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 167539000638 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 167539000639 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 167539000640 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 167539000641 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 167539000642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 167539000643 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 167539000644 synthetase active site [active] 167539000645 NTP binding site [chemical binding]; other site 167539000646 metal binding site [ion binding]; metal-binding site 167539000647 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 167539000648 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 167539000649 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 167539000650 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 167539000651 Walker A/P-loop; other site 167539000652 ATP binding site [chemical binding]; other site 167539000653 Q-loop/lid; other site 167539000654 ABC transporter signature motif; other site 167539000655 Walker B; other site 167539000656 D-loop; other site 167539000657 H-loop/switch region; other site 167539000658 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 167539000659 Walker A/P-loop; other site 167539000660 ATP binding site [chemical binding]; other site 167539000661 Q-loop/lid; other site 167539000662 ABC transporter signature motif; other site 167539000663 Walker B; other site 167539000664 D-loop; other site 167539000665 H-loop/switch region; other site 167539000666 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 167539000667 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539000668 RNA binding surface [nucleotide binding]; other site 167539000669 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 167539000670 active site 167539000671 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 167539000672 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 167539000673 GTP/Mg2+ binding site [chemical binding]; other site 167539000674 G4 box; other site 167539000675 G5 box; other site 167539000676 G1 box; other site 167539000677 Switch I region; other site 167539000678 G2 box; other site 167539000679 G3 box; other site 167539000680 Switch II region; other site 167539000681 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 167539000682 Phosphoglycerate kinase; Region: PGK; pfam00162 167539000683 substrate binding site [chemical binding]; other site 167539000684 hinge regions; other site 167539000685 ADP binding site [chemical binding]; other site 167539000686 catalytic site [active] 167539000687 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 167539000688 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 167539000689 active site 167539000690 homodimer interface [polypeptide binding]; other site 167539000691 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 167539000692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539000693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000694 homodimer interface [polypeptide binding]; other site 167539000695 catalytic residue [active] 167539000696 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 167539000697 quinone interaction residues [chemical binding]; other site 167539000698 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 167539000699 active site 167539000700 catalytic residues [active] 167539000701 FMN binding site [chemical binding]; other site 167539000702 substrate binding site [chemical binding]; other site 167539000703 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 167539000704 RNA/DNA hybrid binding site [nucleotide binding]; other site 167539000705 active site 167539000706 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 167539000707 L11 interface [polypeptide binding]; other site 167539000708 putative EF-Tu interaction site [polypeptide binding]; other site 167539000709 putative EF-G interaction site [polypeptide binding]; other site 167539000710 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 167539000711 23S rRNA interface [nucleotide binding]; other site 167539000712 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 167539000713 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 167539000714 mRNA/rRNA interface [nucleotide binding]; other site 167539000715 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 167539000716 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 167539000717 23S rRNA interface [nucleotide binding]; other site 167539000718 L7/L12 interface [polypeptide binding]; other site 167539000719 putative thiostrepton binding site; other site 167539000720 L25 interface [polypeptide binding]; other site 167539000721 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 167539000722 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 167539000723 putative homodimer interface [polypeptide binding]; other site 167539000724 KOW motif; Region: KOW; cl00354 167539000725 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 167539000726 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167539000727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000728 Walker A motif; other site 167539000729 ATP binding site [chemical binding]; other site 167539000730 Walker B motif; other site 167539000731 arginine finger; other site 167539000732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000733 Walker A motif; other site 167539000734 ATP binding site [chemical binding]; other site 167539000735 Walker B motif; other site 167539000736 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167539000737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167539000738 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 167539000739 dimer interface [polypeptide binding]; other site 167539000740 active site 167539000741 metal binding site [ion binding]; metal-binding site 167539000742 glutathione binding site [chemical binding]; other site 167539000743 enolase; Provisional; Region: eno; PRK00077 167539000744 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 167539000745 dimer interface [polypeptide binding]; other site 167539000746 metal binding site [ion binding]; metal-binding site 167539000747 substrate binding pocket [chemical binding]; other site 167539000748 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539000749 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167539000750 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539000751 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167539000752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000753 Domain of unknown function (DUF897); Region: DUF897; cl01312 167539000754 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167539000755 Sulfate transporter family; Region: Sulfate_transp; cl15842 167539000756 Sulfate transporter family; Region: Sulfate_transp; cl15842 167539000757 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167539000758 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 167539000759 dimer interface [polypeptide binding]; other site 167539000760 active site 167539000761 aspartate-rich active site metal binding site; other site 167539000762 allosteric magnesium binding site [ion binding]; other site 167539000763 Schiff base residues; other site 167539000764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167539000765 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 167539000766 active site 167539000767 metal binding site [ion binding]; metal-binding site 167539000768 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167539000769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000770 Walker A/P-loop; other site 167539000771 ATP binding site [chemical binding]; other site 167539000772 Q-loop/lid; other site 167539000773 ABC transporter signature motif; other site 167539000774 Walker B; other site 167539000775 D-loop; other site 167539000776 H-loop/switch region; other site 167539000777 Smr domain; Region: Smr; cl02619 167539000778 GTPase CgtA; Reviewed; Region: obgE; PRK12299 167539000779 GTP1/OBG; Region: GTP1_OBG; pfam01018 167539000780 Obg GTPase; Region: Obg; cd01898 167539000781 G1 box; other site 167539000782 GTP/Mg2+ binding site [chemical binding]; other site 167539000783 Switch I region; other site 167539000784 G2 box; other site 167539000785 G3 box; other site 167539000786 Switch II region; other site 167539000787 G4 box; other site 167539000788 G5 box; other site 167539000789 CP12 domain; Region: CP12; cl14670 167539000790 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 167539000791 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 167539000792 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 167539000793 putative dimer interface [polypeptide binding]; other site 167539000794 N-terminal domain interface [polypeptide binding]; other site 167539000795 putative substrate binding pocket (H-site) [chemical binding]; other site 167539000796 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 167539000797 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 167539000798 active site 167539000799 Zn binding site [ion binding]; other site 167539000800 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167539000801 protein I interface; other site 167539000802 D2 interface; other site 167539000803 protein T interface; other site 167539000804 chlorophyll binding site; other site 167539000805 beta carotene binding site; other site 167539000806 pheophytin binding site; other site 167539000807 manganese-stabilizing polypeptide interface; other site 167539000808 CP43 interface; other site 167539000809 protein L interface; other site 167539000810 oxygen evolving complex binding site; other site 167539000811 bromide binding site; other site 167539000812 quinone binding site; other site 167539000813 Fe binding site [ion binding]; other site 167539000814 core light harvesting interface; other site 167539000815 cytochrome b559 alpha subunit interface; other site 167539000816 cytochrome c-550 interface; other site 167539000817 protein J interface; other site 167539000818 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 167539000819 Tetramer interface [polypeptide binding]; other site 167539000820 active site 167539000821 FMN-binding site [chemical binding]; other site 167539000822 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 167539000823 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 167539000824 active site 167539000825 intersubunit interface [polypeptide binding]; other site 167539000826 catalytic residue [active] 167539000827 FtsH Extracellular; Region: FtsH_ext; pfam06480 167539000828 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167539000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539000830 Walker A motif; other site 167539000831 ATP binding site [chemical binding]; other site 167539000832 Walker B motif; other site 167539000833 arginine finger; other site 167539000834 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539000835 ATP sulphurylase; Region: sopT; TIGR00339 167539000836 ATP-sulfurylase; Region: ATPS; cd00517 167539000837 active site 167539000838 HXXH motif; other site 167539000839 flexible loop; other site 167539000840 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 167539000841 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 167539000842 Flavoprotein; Region: Flavoprotein; cl08021 167539000843 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 167539000844 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 167539000845 Protein of unknown function (DUF565); Region: DUF565; pfam04483 167539000846 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 167539000847 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167539000848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000849 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 167539000850 active site 167539000851 DNA binding site [nucleotide binding] 167539000852 Creatinine amidohydrolase; Region: Creatininase; cl00618 167539000853 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 167539000854 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 167539000855 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 167539000856 putative di-iron ligands [ion binding]; other site 167539000857 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 167539000858 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539000859 active site 167539000860 HIGH motif; other site 167539000861 nucleotide binding site [chemical binding]; other site 167539000862 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167539000863 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 167539000864 active site 167539000865 KMSKS motif; other site 167539000866 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 167539000867 tRNA binding surface [nucleotide binding]; other site 167539000868 anticodon binding site; other site 167539000869 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167539000870 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 167539000871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 167539000872 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 167539000873 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 167539000874 active site 167539000875 substrate binding site [chemical binding]; other site 167539000876 metal binding site [ion binding]; metal-binding site 167539000877 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 167539000878 catalytic residues [active] 167539000879 Thymidylate synthase complementing protein; Region: Thy1; cl03630 167539000880 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 167539000881 trimer interface [polypeptide binding]; other site 167539000882 active site 167539000883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539000884 Walker A motif; other site 167539000885 ATP binding site [chemical binding]; other site 167539000886 Walker B motif; other site 167539000887 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 167539000888 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 167539000889 ligand binding site [chemical binding]; other site 167539000890 flexible hinge region; other site 167539000891 Helix-turn-helix domains; Region: HTH; cl00088 167539000892 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 167539000893 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 167539000894 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 167539000895 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 167539000896 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 167539000897 putative active site [active] 167539000898 catalytic residue [active] 167539000899 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 167539000900 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 167539000901 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 167539000902 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 167539000903 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 167539000904 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 167539000905 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 167539000906 substrate binding site [chemical binding]; other site 167539000907 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 167539000908 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 167539000909 substrate binding site [chemical binding]; other site 167539000910 ligand binding site [chemical binding]; other site 167539000911 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 167539000912 competence damage-inducible protein A; Provisional; Region: PRK00549 167539000913 putative MPT binding site; other site 167539000914 Competence-damaged protein; Region: CinA; cl00666 167539000915 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 167539000916 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 167539000917 dimer interface [polypeptide binding]; other site 167539000918 active site 167539000919 glycine-pyridoxal phosphate binding site [chemical binding]; other site 167539000920 folate binding site [chemical binding]; other site 167539000921 2TM domain; Region: 2TM; pfam13239 167539000922 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 167539000923 integral membrane protein MviN; Region: mviN; TIGR01695 167539000924 Sugar fermentation stimulation protein; Region: SfsA; cl00647 167539000925 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 167539000926 LytB protein; Region: LYTB; cl00507 167539000927 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 167539000928 DoxX; Region: DoxX; cl00976 167539000929 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 167539000930 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 167539000931 purine monophosphate binding site [chemical binding]; other site 167539000932 dimer interface [polypeptide binding]; other site 167539000933 putative catalytic residues [active] 167539000934 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 167539000935 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 167539000936 Predicted esterase [General function prediction only]; Region: COG0400 167539000937 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167539000938 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 167539000939 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 167539000940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167539000941 dimer interface [polypeptide binding]; other site 167539000942 phosphorylation site [posttranslational modification] 167539000943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539000944 ATP binding site [chemical binding]; other site 167539000945 Mg2+ binding site [ion binding]; other site 167539000946 G-X-G motif; other site 167539000947 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 167539000948 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 167539000949 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 167539000950 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 167539000951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167539000952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539000953 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 167539000954 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 167539000955 Domain of unknown function DUF21; Region: DUF21; pfam01595 167539000956 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167539000957 Transporter associated domain; Region: CorC_HlyC; cl08393 167539000958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539000959 active site 167539000960 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 167539000961 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 167539000962 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167539000963 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167539000964 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 167539000965 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 167539000966 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 167539000967 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 167539000968 active site 167539000969 substrate binding site [chemical binding]; other site 167539000970 metal binding site [ion binding]; metal-binding site 167539000971 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167539000972 active site 167539000973 dimerization interface [polypeptide binding]; other site 167539000974 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 167539000975 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 167539000976 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 167539000977 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 167539000978 putative active site pocket [active] 167539000979 4-fold oligomerization interface [polypeptide binding]; other site 167539000980 metal binding residues [ion binding]; metal-binding site 167539000981 3-fold/trimer interface [polypeptide binding]; other site 167539000982 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 167539000983 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 167539000984 NAD binding site [chemical binding]; other site 167539000985 homotetramer interface [polypeptide binding]; other site 167539000986 homodimer interface [polypeptide binding]; other site 167539000987 substrate binding site [chemical binding]; other site 167539000988 active site 167539000989 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 167539000990 putative catalytic residue [active] 167539000991 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 167539000992 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167539000993 inhibitor-cofactor binding pocket; inhibition site 167539000994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539000995 catalytic residue [active] 167539000996 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 167539000997 dimer interface [polypeptide binding]; other site 167539000998 ADP-ribose binding site [chemical binding]; other site 167539000999 active site 167539001000 nudix motif; other site 167539001001 metal binding site [ion binding]; metal-binding site 167539001002 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 167539001003 catalytic center binding site [active] 167539001004 ATP binding site [chemical binding]; other site 167539001005 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 167539001006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001007 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 167539001008 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 167539001009 metal ion-dependent adhesion site (MIDAS); other site 167539001010 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 167539001011 mce related protein; Region: MCE; pfam02470 167539001012 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 167539001013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001014 Walker A/P-loop; other site 167539001015 ATP binding site [chemical binding]; other site 167539001016 Q-loop/lid; other site 167539001017 ABC transporter signature motif; other site 167539001018 Walker B; other site 167539001019 D-loop; other site 167539001020 H-loop/switch region; other site 167539001021 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 167539001022 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 167539001023 phosphate binding site [ion binding]; other site 167539001024 putative substrate binding pocket [chemical binding]; other site 167539001025 dimer interface [polypeptide binding]; other site 167539001026 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 167539001027 NADH dehydrogenase subunit B; Validated; Region: PRK06411 167539001028 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 167539001029 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 167539001030 Rubredoxin [Energy production and conversion]; Region: COG1773 167539001031 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 167539001032 iron binding site [ion binding]; other site 167539001033 Ycf48-like protein; Provisional; Region: PRK13684 167539001034 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 167539001035 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 167539001036 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 167539001037 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 167539001038 PsbL protein; Region: PsbL; cl03581 167539001039 PsbJ; Region: PsbJ; cl09469 167539001040 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167539001041 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 167539001042 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 167539001043 dimerization interface [polypeptide binding]; other site 167539001044 putative ATP binding site [chemical binding]; other site 167539001045 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167539001046 active site 167539001047 NTP binding site [chemical binding]; other site 167539001048 metal binding triad [ion binding]; metal-binding site 167539001049 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 167539001050 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 167539001051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001052 Family description; Region: UvrD_C_2; cl15862 167539001053 Phycobilisome protein; Region: Phycobilisome; cl08227 167539001054 Phycobilisome protein; Region: Phycobilisome; cl08227 167539001055 HEAT repeats; Region: HEAT_2; pfam13646 167539001056 HEAT repeats; Region: HEAT_2; pfam13646 167539001057 HEAT repeats; Region: HEAT_2; pfam13646 167539001058 HEAT repeats; Region: HEAT_2; pfam13646 167539001059 HEAT repeats; Region: HEAT_2; pfam13646 167539001060 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 167539001061 CpeS-like protein; Region: CpeS; pfam09367 167539001062 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 167539001063 PUCC protein; Region: PUCC; pfam03209 167539001064 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 167539001065 N- and C-terminal domain interface [polypeptide binding]; other site 167539001066 active site 167539001067 MgATP binding site [chemical binding]; other site 167539001068 catalytic site [active] 167539001069 metal binding site [ion binding]; metal-binding site 167539001070 carbohydrate binding site [chemical binding]; other site 167539001071 S-adenosylmethionine synthetase; Validated; Region: PRK05250 167539001072 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 167539001073 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 167539001074 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 167539001075 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167539001076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539001077 motif II; other site 167539001078 30S ribosomal protein S1; Reviewed; Region: PRK07400 167539001079 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167539001080 RNA binding site [nucleotide binding]; other site 167539001081 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167539001082 RNA binding site [nucleotide binding]; other site 167539001083 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 167539001084 RNA binding site [nucleotide binding]; other site 167539001085 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 167539001086 ATP cone domain; Region: ATP-cone; pfam03477 167539001087 Photosystem II reaction centre T protein; Region: PsbT; cl11601 167539001088 Photosystem II protein; Region: PSII; cl08223 167539001089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539001090 catalytic loop [active] 167539001091 iron binding site [ion binding]; other site 167539001092 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 167539001093 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167539001094 active site 167539001095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001096 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 167539001097 Septum formation topological specificity factor MinE; Region: MinE; cl00538 167539001098 septum site-determining protein MinD; Region: minD_bact; TIGR01968 167539001099 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 167539001100 P-loop; other site 167539001101 ADP binding residues [chemical binding]; other site 167539001102 Switch I; other site 167539001103 Switch II; other site 167539001104 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 167539001105 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 167539001106 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 167539001107 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167539001108 Zn2+ binding site [ion binding]; other site 167539001109 Mg2+ binding site [ion binding]; other site 167539001110 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167539001111 C-terminal peptidase (prc); Region: prc; TIGR00225 167539001112 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167539001113 protein binding site [polypeptide binding]; other site 167539001114 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167539001115 Catalytic dyad [active] 167539001116 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 167539001117 Qi binding site; other site 167539001118 intrachain domain interface; other site 167539001119 interchain domain interface [polypeptide binding]; other site 167539001120 heme bH binding site [chemical binding]; other site 167539001121 heme bL binding site [chemical binding]; other site 167539001122 Qo binding site; other site 167539001123 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 167539001124 interchain domain interface [polypeptide binding]; other site 167539001125 intrachain domain interface; other site 167539001126 Qi binding site; other site 167539001127 Qo binding site; other site 167539001128 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 167539001129 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 167539001130 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 167539001131 DNA binding site [nucleotide binding] 167539001132 catalytic residue [active] 167539001133 H2TH interface [polypeptide binding]; other site 167539001134 putative catalytic residues [active] 167539001135 turnover-facilitating residue; other site 167539001136 intercalation triad [nucleotide binding]; other site 167539001137 8OG recognition residue [nucleotide binding]; other site 167539001138 putative reading head residues; other site 167539001139 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167539001140 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167539001141 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 167539001142 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 167539001143 putative peptidoglycan binding site; other site 167539001144 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 167539001145 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 167539001146 putative peptidoglycan binding site; other site 167539001147 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 167539001148 putative peptidoglycan binding site; other site 167539001149 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 167539001150 NAD(P) binding site [chemical binding]; other site 167539001151 catalytic residues [active] 167539001152 flavoprotein, HI0933 family; Region: TIGR00275 167539001153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001154 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167539001155 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 167539001156 Rubredoxin; Region: Rubredoxin; pfam00301 167539001157 iron binding site [ion binding]; other site 167539001158 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167539001159 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167539001160 Ligand binding site; other site 167539001161 Putative Catalytic site; other site 167539001162 DXD motif; other site 167539001163 Predicted membrane protein [Function unknown]; Region: COG3463 167539001164 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 167539001165 Predicted membrane protein [Function unknown]; Region: COG3463 167539001166 GtrA-like protein; Region: GtrA; cl00971 167539001167 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 167539001168 active site 167539001169 trimer interface [polypeptide binding]; other site 167539001170 dimer interface [polypeptide binding]; other site 167539001171 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 167539001172 active site 167539001173 dinuclear metal binding site [ion binding]; other site 167539001174 dimerization interface [polypeptide binding]; other site 167539001175 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 167539001176 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 167539001177 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 167539001178 GTP-binding protein Der; Reviewed; Region: PRK00093 167539001179 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 167539001180 G1 box; other site 167539001181 GTP/Mg2+ binding site [chemical binding]; other site 167539001182 Switch I region; other site 167539001183 G2 box; other site 167539001184 Switch II region; other site 167539001185 G3 box; other site 167539001186 G4 box; other site 167539001187 G5 box; other site 167539001188 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 167539001189 G1 box; other site 167539001190 GTP/Mg2+ binding site [chemical binding]; other site 167539001191 Switch I region; other site 167539001192 G2 box; other site 167539001193 G3 box; other site 167539001194 Switch II region; other site 167539001195 G4 box; other site 167539001196 G5 box; other site 167539001197 Cobalt transport protein; Region: CbiQ; cl00463 167539001198 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 167539001199 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 167539001200 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539001201 catalytic residue [active] 167539001202 Protein of unknown function (DUF552); Region: DUF552; cl00775 167539001203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001204 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 167539001205 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167539001206 Recombination protein O N terminal; Region: RecO_N; cl15812 167539001207 Recombination protein O C terminal; Region: RecO_C; pfam02565 167539001208 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 167539001209 intersubunit interface [polypeptide binding]; other site 167539001210 active site 167539001211 catalytic residue [active] 167539001212 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 167539001213 30S subunit binding site; other site 167539001214 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 167539001215 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 167539001216 AMP-binding enzyme; Region: AMP-binding; cl15778 167539001217 AMP-binding enzyme; Region: AMP-binding; cl15778 167539001218 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 167539001219 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 167539001220 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 167539001221 E3 interaction surface; other site 167539001222 lipoyl attachment site [posttranslational modification]; other site 167539001223 e3 binding domain; Region: E3_binding; pfam02817 167539001224 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 167539001225 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 167539001226 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 167539001227 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167539001228 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167539001229 dimer interface [polypeptide binding]; other site 167539001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539001231 catalytic residue [active] 167539001232 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539001233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539001234 catalytic residue [active] 167539001235 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 167539001236 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167539001237 homodimer interface [polypeptide binding]; other site 167539001238 substrate-cofactor binding pocket; other site 167539001239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539001240 catalytic residue [active] 167539001241 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 167539001242 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 167539001243 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 167539001244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539001245 RNA binding surface [nucleotide binding]; other site 167539001246 Haemolytic domain; Region: Haemolytic; cl00506 167539001247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539001248 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 167539001249 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167539001250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539001251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539001252 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167539001253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539001254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539001255 catalytic residue [active] 167539001256 NifU-like domain; Region: NifU; cl00484 167539001257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001258 Predicted dehydrogenase [General function prediction only]; Region: COG0579 167539001259 GTP-binding protein LepA; Provisional; Region: PRK05433 167539001260 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 167539001261 G1 box; other site 167539001262 putative GEF interaction site [polypeptide binding]; other site 167539001263 GTP/Mg2+ binding site [chemical binding]; other site 167539001264 Switch I region; other site 167539001265 G2 box; other site 167539001266 G3 box; other site 167539001267 Switch II region; other site 167539001268 G4 box; other site 167539001269 G5 box; other site 167539001270 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 167539001271 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 167539001272 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 167539001273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 167539001274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001275 dimer interface [polypeptide binding]; other site 167539001276 conserved gate region; other site 167539001277 ABC-ATPase subunit interface; other site 167539001278 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 167539001279 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167539001280 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 167539001281 16S rRNA methyltransferase B; Provisional; Region: PRK14901 167539001282 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 167539001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539001284 S-adenosylmethionine binding site [chemical binding]; other site 167539001285 Transglycosylase; Region: Transgly; cl07896 167539001286 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 167539001287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539001288 UbiA prenyltransferase family; Region: UbiA; cl00337 167539001289 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167539001290 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167539001291 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167539001292 substrate binding site [chemical binding]; other site 167539001293 glutamase interaction surface [polypeptide binding]; other site 167539001294 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 167539001295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539001296 S-adenosylmethionine binding site [chemical binding]; other site 167539001297 Protein of unknown function (DUF721); Region: DUF721; cl02324 167539001298 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 167539001299 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 167539001300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167539001301 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 167539001302 Walker A/P-loop; other site 167539001303 ATP binding site [chemical binding]; other site 167539001304 Q-loop/lid; other site 167539001305 ABC transporter signature motif; other site 167539001306 Walker B; other site 167539001307 D-loop; other site 167539001308 H-loop/switch region; other site 167539001309 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 167539001310 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167539001311 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 167539001312 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 167539001313 active site 167539001314 putative metal-binding site [ion binding]; other site 167539001315 interdomain interaction site; other site 167539001316 nucleotide binding site [chemical binding]; other site 167539001317 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 167539001318 domain I; other site 167539001319 DNA binding groove [nucleotide binding] 167539001320 phosphate binding site [ion binding]; other site 167539001321 domain II; other site 167539001322 domain III; other site 167539001323 nucleotide binding site [chemical binding]; other site 167539001324 catalytic site [active] 167539001325 domain IV; other site 167539001326 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167539001327 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167539001328 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 167539001329 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 167539001330 putative dimer interface [polypeptide binding]; other site 167539001331 active site pocket [active] 167539001332 putative cataytic base [active] 167539001333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167539001334 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167539001335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167539001336 active site 167539001337 catalytic tetrad [active] 167539001338 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 167539001339 Lumazine binding domain; Region: Lum_binding; pfam00677 167539001340 Lumazine binding domain; Region: Lum_binding; pfam00677 167539001341 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539001342 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167539001343 Subunit I/III interface [polypeptide binding]; other site 167539001344 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 167539001345 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 167539001346 D-pathway; other site 167539001347 Putative ubiquinol binding site [chemical binding]; other site 167539001348 Low-spin heme (heme b) binding site [chemical binding]; other site 167539001349 Putative water exit pathway; other site 167539001350 Binuclear center (heme o3/CuB) [ion binding]; other site 167539001351 K-pathway; other site 167539001352 Putative proton exit pathway; other site 167539001353 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 167539001354 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 167539001355 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 167539001356 UbiA prenyltransferase family; Region: UbiA; cl00337 167539001357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001358 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 167539001359 Walker A/P-loop; other site 167539001360 ATP binding site [chemical binding]; other site 167539001361 Q-loop/lid; other site 167539001362 ABC transporter signature motif; other site 167539001363 Walker B; other site 167539001364 D-loop; other site 167539001365 H-loop/switch region; other site 167539001366 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 167539001367 ABC-2 type transporter; Region: ABC2_membrane; cl11417 167539001368 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167539001369 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167539001370 ring oligomerisation interface [polypeptide binding]; other site 167539001371 ATP/Mg binding site [chemical binding]; other site 167539001372 stacking interactions; other site 167539001373 hinge regions; other site 167539001374 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 167539001375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 167539001376 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 167539001377 NAD(P) binding site [chemical binding]; other site 167539001378 homotetramer interface [polypeptide binding]; other site 167539001379 homodimer interface [polypeptide binding]; other site 167539001380 active site 167539001381 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 167539001382 substrate binding site; other site 167539001383 dimer interface; other site 167539001384 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 167539001385 dimer interface [polypeptide binding]; other site 167539001386 catalytic triad [active] 167539001387 UbiA prenyltransferase family; Region: UbiA; cl00337 167539001388 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 167539001389 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 167539001390 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 167539001391 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 167539001392 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 167539001393 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 167539001394 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 167539001395 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 167539001396 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 167539001397 cytochrome b subunit interaction site [polypeptide binding]; other site 167539001398 [2Fe-2S] cluster binding site [ion binding]; other site 167539001399 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 167539001400 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 167539001401 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 167539001402 Domain of unknown function (DUF814); Region: DUF814; pfam05670 167539001403 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 167539001404 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 167539001405 catalytic site [active] 167539001406 G-X2-G-X-G-K; other site 167539001407 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 167539001408 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 167539001409 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 167539001410 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 167539001411 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 167539001412 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 167539001413 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167539001414 HIGH motif; other site 167539001415 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167539001416 active site 167539001417 KMSKS motif; other site 167539001418 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 167539001419 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 167539001420 active site 167539001421 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 167539001422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001423 NAD(P) binding site [chemical binding]; other site 167539001424 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 167539001425 DRTGG domain; Region: DRTGG; cl12147 167539001426 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 167539001427 Protein of unknown function (DUF520); Region: DUF520; cl00723 167539001428 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 167539001429 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 167539001430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167539001431 inhibitor-cofactor binding pocket; inhibition site 167539001432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539001433 catalytic residue [active] 167539001434 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 167539001435 putative catalytic site [active] 167539001436 putative phosphate binding site [ion binding]; other site 167539001437 active site 167539001438 metal binding site A [ion binding]; metal-binding site 167539001439 DNA binding site [nucleotide binding] 167539001440 putative AP binding site [nucleotide binding]; other site 167539001441 putative metal binding site B [ion binding]; other site 167539001442 Protein of unknown function DUF111; Region: DUF111; cl03398 167539001443 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 167539001444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001445 dimer interface [polypeptide binding]; other site 167539001446 conserved gate region; other site 167539001447 putative PBP binding loops; other site 167539001448 ABC-ATPase subunit interface; other site 167539001449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001450 dimer interface [polypeptide binding]; other site 167539001451 conserved gate region; other site 167539001452 putative PBP binding loops; other site 167539001453 ABC-ATPase subunit interface; other site 167539001454 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167539001455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001456 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167539001457 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 167539001458 aromatic arch; other site 167539001459 DCoH dimer interaction site [polypeptide binding]; other site 167539001460 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167539001461 DCoH tetramer interaction site [polypeptide binding]; other site 167539001462 substrate binding site [chemical binding]; other site 167539001463 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 167539001464 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 167539001465 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 167539001466 active site 167539001467 Zn binding site [ion binding]; other site 167539001468 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167539001469 dimer interface [polypeptide binding]; other site 167539001470 substrate binding site [chemical binding]; other site 167539001471 metal binding sites [ion binding]; metal-binding site 167539001472 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 167539001473 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 167539001474 domain interfaces; other site 167539001475 active site 167539001476 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 167539001477 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539001478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539001479 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539001480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539001481 DNA binding residues [nucleotide binding] 167539001482 primosome assembly protein PriA; Validated; Region: PRK05580 167539001483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539001484 ATP binding site [chemical binding]; other site 167539001485 putative Mg++ binding site [ion binding]; other site 167539001486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539001487 ATP-binding site [chemical binding]; other site 167539001488 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 167539001489 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 167539001490 feedback inhibition sensing region; other site 167539001491 homohexameric interface [polypeptide binding]; other site 167539001492 nucleotide binding site [chemical binding]; other site 167539001493 N-acetyl-L-glutamate binding site [chemical binding]; other site 167539001494 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 167539001495 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167539001496 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167539001497 ssDNA binding site [nucleotide binding]; other site 167539001498 dimer interface [polypeptide binding]; other site 167539001499 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167539001500 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 167539001501 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 167539001502 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 167539001503 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 167539001504 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167539001505 substrate binding site [chemical binding]; other site 167539001506 ATP binding site [chemical binding]; other site 167539001507 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 167539001508 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 167539001509 GDP-binding site [chemical binding]; other site 167539001510 ACT binding site; other site 167539001511 IMP binding site; other site 167539001512 Photosystem II Pbs27; Region: PSII_Pbs27; cl11841 167539001513 prolyl-tRNA synthetase; Provisional; Region: PRK09194 167539001514 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 167539001515 dimer interface [polypeptide binding]; other site 167539001516 motif 1; other site 167539001517 active site 167539001518 motif 2; other site 167539001519 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 167539001520 putative deacylase active site [active] 167539001521 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 167539001522 active site 167539001523 motif 3; other site 167539001524 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 167539001525 anticodon binding site; other site 167539001526 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167539001527 dimer interface [polypeptide binding]; other site 167539001528 substrate binding site [chemical binding]; other site 167539001529 metal binding sites [ion binding]; metal-binding site 167539001530 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 167539001531 ArsC family; Region: ArsC; pfam03960 167539001532 putative ArsC-like catalytic residues; other site 167539001533 putative TRX-like catalytic residues [active] 167539001534 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167539001535 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539001536 Catalytic site [active] 167539001537 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539001538 dihydroorotase; Provisional; Region: PRK07369 167539001539 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 167539001540 active site 167539001541 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167539001542 catalytic core [active] 167539001543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167539001544 catalytic core [active] 167539001545 CAAX protease self-immunity; Region: Abi; cl00558 167539001546 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 167539001547 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167539001548 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539001549 transaldolase-like protein; Provisional; Region: PTZ00411 167539001550 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 167539001551 active site 167539001552 dimer interface [polypeptide binding]; other site 167539001553 catalytic residue [active] 167539001554 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 167539001555 ribosome recycling factor; Reviewed; Region: frr; PRK00083 167539001556 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 167539001557 hinge region; other site 167539001558 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 167539001559 putative nucleotide binding site [chemical binding]; other site 167539001560 uridine monophosphate binding site [chemical binding]; other site 167539001561 homohexameric interface [polypeptide binding]; other site 167539001562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001563 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 167539001564 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167539001565 homodimer interface [polypeptide binding]; other site 167539001566 Walker A motif; other site 167539001567 ATP binding site [chemical binding]; other site 167539001568 hydroxycobalamin binding site [chemical binding]; other site 167539001569 Walker B motif; other site 167539001570 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 167539001571 active site 167539001572 catalytic residues [active] 167539001573 DNA binding site [nucleotide binding] 167539001574 Int/Topo IB signature motif; other site 167539001575 ferrochelatase; Reviewed; Region: hemH; PRK00035 167539001576 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 167539001577 C-terminal domain interface [polypeptide binding]; other site 167539001578 active site 167539001579 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 167539001580 active site 167539001581 N-terminal domain interface [polypeptide binding]; other site 167539001582 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 167539001583 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 167539001584 PYR/PP interface [polypeptide binding]; other site 167539001585 dimer interface [polypeptide binding]; other site 167539001586 TPP binding site [chemical binding]; other site 167539001587 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 167539001588 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 167539001589 TPP-binding site [chemical binding]; other site 167539001590 dimer interface [polypeptide binding]; other site 167539001591 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 167539001592 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 167539001593 30S ribosomal protein S1; Reviewed; Region: PRK07400 167539001594 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167539001595 RNA binding site [nucleotide binding]; other site 167539001596 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167539001597 RNA binding site [nucleotide binding]; other site 167539001598 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539001599 RNA binding site [nucleotide binding]; other site 167539001600 Creatinine amidohydrolase; Region: Creatininase; cl00618 167539001601 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 167539001602 dinuclear metal binding motif [ion binding]; other site 167539001603 acyl-ACP reductase; Provisional; Region: PRK14982 167539001604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001605 NAD(P) binding pocket [chemical binding]; other site 167539001606 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 167539001607 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 167539001608 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 167539001609 classical (c) SDRs; Region: SDR_c; cd05233 167539001610 NAD(P) binding site [chemical binding]; other site 167539001611 active site 167539001612 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539001613 GTP cyclohydrolase I; Provisional; Region: PLN03044 167539001614 active site 167539001615 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 167539001616 active site 167539001617 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 167539001618 active site 167539001619 putative substrate binding region [chemical binding]; other site 167539001620 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167539001621 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 167539001622 Photosystem I protein M (PsaM); Region: PsaM; cl15374 167539001623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001624 NAD(P) binding site [chemical binding]; other site 167539001625 active site 167539001626 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 167539001627 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 167539001628 P-loop; other site 167539001629 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 167539001630 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 167539001631 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 167539001632 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 167539001633 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 167539001634 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 167539001635 putative hexamer interface [polypeptide binding]; other site 167539001636 putative hexagonal pore; other site 167539001637 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 167539001638 putative hexamer interface [polypeptide binding]; other site 167539001639 putative hexagonal pore; other site 167539001640 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167539001641 active site 167539001642 dimerization interface [polypeptide binding]; other site 167539001643 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167539001644 Hexamer interface [polypeptide binding]; other site 167539001645 Hexagonal pore residue; other site 167539001646 Hexagonal pore; other site 167539001647 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 167539001648 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 167539001649 dimer interface [polypeptide binding]; other site 167539001650 catalytic residue [active] 167539001651 metal binding site [ion binding]; metal-binding site 167539001652 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 167539001653 multimerization interface [polypeptide binding]; other site 167539001654 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167539001655 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167539001656 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 167539001657 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167539001658 Hexamer/Pentamer interface [polypeptide binding]; other site 167539001659 central pore; other site 167539001660 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167539001661 Hexamer/Pentamer interface [polypeptide binding]; other site 167539001662 central pore; other site 167539001663 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167539001664 Hexamer interface [polypeptide binding]; other site 167539001665 Hexagonal pore residue; other site 167539001666 Hexagonal pore; other site 167539001667 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 167539001668 aromatic arch; other site 167539001669 DCoH dimer interaction site [polypeptide binding]; other site 167539001670 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167539001671 DCoH tetramer interaction site [polypeptide binding]; other site 167539001672 substrate binding site [chemical binding]; other site 167539001673 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 167539001674 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 167539001675 homotrimer interaction site [polypeptide binding]; other site 167539001676 putative active site [active] 167539001677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539001678 ATP phosphoribosyltransferase; Region: HisG; cl15266 167539001679 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167539001680 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 167539001681 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 167539001682 Walker A/P-loop; other site 167539001683 ATP binding site [chemical binding]; other site 167539001684 Q-loop/lid; other site 167539001685 ABC transporter signature motif; other site 167539001686 Walker B; other site 167539001687 D-loop; other site 167539001688 H-loop/switch region; other site 167539001689 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 167539001690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167539001691 Coenzyme A binding pocket [chemical binding]; other site 167539001692 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 167539001693 Probable Catalytic site; other site 167539001694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167539001695 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 167539001696 DnaA N-terminal domain; Region: DnaA_N; pfam11638 167539001697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539001698 Walker A motif; other site 167539001699 ATP binding site [chemical binding]; other site 167539001700 Walker B motif; other site 167539001701 arginine finger; other site 167539001702 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 167539001703 DnaA box-binding interface [nucleotide binding]; other site 167539001704 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167539001705 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167539001706 C-terminal domain interface [polypeptide binding]; other site 167539001707 GSH binding site (G-site) [chemical binding]; other site 167539001708 dimer interface [polypeptide binding]; other site 167539001709 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167539001710 N-terminal domain interface [polypeptide binding]; other site 167539001711 glutathione reductase; Validated; Region: PRK06116 167539001712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539001713 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167539001714 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167539001715 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167539001716 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 167539001717 active site 167539001718 substrate binding pocket [chemical binding]; other site 167539001719 dimer interface [polypeptide binding]; other site 167539001720 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 167539001721 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167539001722 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 167539001723 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 167539001724 substrate binding site [chemical binding]; other site 167539001725 active site 167539001726 catalytic residues [active] 167539001727 heterodimer interface [polypeptide binding]; other site 167539001728 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539001729 YCII-related domain; Region: YCII; cl00999 167539001730 Cytochrome c; Region: Cytochrom_C; cl11414 167539001731 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 167539001732 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539001733 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539001734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539001735 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539001736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539001737 DNA binding residues [nucleotide binding] 167539001738 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 167539001739 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 167539001740 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 167539001741 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167539001742 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539001743 carotene isomerase; Region: carot_isom; TIGR02730 167539001744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001746 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 167539001747 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 167539001748 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167539001749 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 167539001750 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 167539001751 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 167539001752 Walker A/P-loop; other site 167539001753 ATP binding site [chemical binding]; other site 167539001754 Q-loop/lid; other site 167539001755 ABC transporter signature motif; other site 167539001756 Walker B; other site 167539001757 D-loop; other site 167539001758 H-loop/switch region; other site 167539001759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001760 dimer interface [polypeptide binding]; other site 167539001761 conserved gate region; other site 167539001762 putative PBP binding loops; other site 167539001763 ABC-ATPase subunit interface; other site 167539001764 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 167539001765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001766 dimer interface [polypeptide binding]; other site 167539001767 conserved gate region; other site 167539001768 putative PBP binding loops; other site 167539001769 ABC-ATPase subunit interface; other site 167539001770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 167539001771 Predicted protein 167539001772 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167539001773 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 167539001774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001775 Family description; Region: UvrD_C_2; cl15862 167539001776 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 167539001777 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 167539001778 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 167539001779 putative active site [active] 167539001780 putative NTP binding site [chemical binding]; other site 167539001781 putative nucleic acid binding site [nucleotide binding]; other site 167539001782 SWIM zinc finger; Region: SWIM; cl15408 167539001783 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539001784 Leucine rich repeat variant; Region: LRV; pfam01816 167539001785 Leucine rich repeat variant; Region: LRV; pfam01816 167539001786 HEAT repeats; Region: HEAT_2; pfam13646 167539001787 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 167539001788 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 167539001789 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 167539001790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539001791 ATP binding site [chemical binding]; other site 167539001792 putative Mg++ binding site [ion binding]; other site 167539001793 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 167539001794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001795 Protein of unknown function (DUF541); Region: SIMPL; cl01077 167539001796 Family of unknown function (DUF500); Region: DUF500; cl01109 167539001797 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 167539001798 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167539001799 Cupin domain; Region: Cupin_2; cl09118 167539001800 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 167539001801 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167539001802 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167539001803 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 167539001804 NmrA-like family; Region: NmrA; pfam05368 167539001805 NADP binding site [chemical binding]; other site 167539001806 active site 167539001807 regulatory binding site [polypeptide binding]; other site 167539001808 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 167539001809 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 167539001810 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 167539001811 Walker A/P-loop; other site 167539001812 ATP binding site [chemical binding]; other site 167539001813 Q-loop/lid; other site 167539001814 ABC transporter signature motif; other site 167539001815 Walker B; other site 167539001816 D-loop; other site 167539001817 H-loop/switch region; other site 167539001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001819 dimer interface [polypeptide binding]; other site 167539001820 conserved gate region; other site 167539001821 putative PBP binding loops; other site 167539001822 ABC-ATPase subunit interface; other site 167539001823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539001824 dimer interface [polypeptide binding]; other site 167539001825 conserved gate region; other site 167539001826 putative PBP binding loops; other site 167539001827 ABC-ATPase subunit interface; other site 167539001828 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 167539001829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 167539001830 substrate binding pocket [chemical binding]; other site 167539001831 membrane-bound complex binding site; other site 167539001832 hinge residues; other site 167539001833 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 167539001834 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 167539001835 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 167539001836 NAD(P) binding site [chemical binding]; other site 167539001837 homodimer interface [polypeptide binding]; other site 167539001838 substrate binding site [chemical binding]; other site 167539001839 active site 167539001840 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 167539001841 Mg++ binding site [ion binding]; other site 167539001842 putative catalytic motif [active] 167539001843 putative substrate binding site [chemical binding]; other site 167539001844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001845 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167539001846 NAD(P) binding site [chemical binding]; other site 167539001847 active site 167539001848 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 167539001849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539001850 putative ADP-binding pocket [chemical binding]; other site 167539001851 Protein of unknown function, DUF393; Region: DUF393; cl01136 167539001852 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 167539001853 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 167539001854 distal heme binding site [chemical binding]; other site 167539001855 proximal heme binding site [chemical binding]; other site 167539001856 putative dimer interface [polypeptide binding]; other site 167539001857 putative Iron-sulfur protein interface [polypeptide binding]; other site 167539001858 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 167539001859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001860 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167539001861 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 167539001862 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 167539001863 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 167539001864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001865 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 167539001866 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 167539001867 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167539001868 active site 167539001869 metal binding site [ion binding]; metal-binding site 167539001870 DNA binding site [nucleotide binding] 167539001871 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167539001872 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 167539001873 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 167539001874 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 167539001875 HsdM N-terminal domain; Region: HsdM_N; pfam12161 167539001876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539001877 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 167539001878 NADP binding site [chemical binding]; other site 167539001879 homodimer interface [polypeptide binding]; other site 167539001880 active site 167539001881 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 167539001882 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 167539001883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167539001884 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167539001885 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167539001886 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 167539001887 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 167539001888 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 167539001889 active site 167539001890 homodimer interface [polypeptide binding]; other site 167539001891 catalytic site [active] 167539001892 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 167539001893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539001894 active site 167539001895 motif I; other site 167539001896 motif II; other site 167539001897 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167539001898 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001899 active site 167539001900 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 167539001901 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 167539001902 Bacitracin resistance protein BacA; Region: BacA; cl00858 167539001903 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167539001904 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539001905 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167539001906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539001907 Walker A/P-loop; other site 167539001908 ATP binding site [chemical binding]; other site 167539001909 Q-loop/lid; other site 167539001910 ABC transporter signature motif; other site 167539001911 Walker B; other site 167539001912 D-loop; other site 167539001913 H-loop/switch region; other site 167539001914 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 167539001915 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 167539001916 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167539001917 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 167539001918 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 167539001919 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 167539001920 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 167539001921 catalytic site [active] 167539001922 subunit interface [polypeptide binding]; other site 167539001923 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 167539001924 anti sigma factor interaction site; other site 167539001925 regulatory phosphorylation site [posttranslational modification]; other site 167539001926 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 167539001927 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 167539001928 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 167539001929 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167539001930 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 167539001931 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 167539001932 Amidase; Region: Amidase; cl11426 167539001933 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 167539001934 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 167539001935 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 167539001936 generic binding surface I; other site 167539001937 generic binding surface II; other site 167539001938 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 167539001939 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 167539001940 16S/18S rRNA binding site [nucleotide binding]; other site 167539001941 S13e-L30e interaction site [polypeptide binding]; other site 167539001942 25S rRNA binding site [nucleotide binding]; other site 167539001943 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 167539001944 RuvA N terminal domain; Region: RuvA_N; pfam01330 167539001945 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167539001946 EamA-like transporter family; Region: EamA; cl01037 167539001947 EamA-like transporter family; Region: EamA; cl01037 167539001948 DNA primase; Validated; Region: dnaG; PRK05667 167539001949 CHC2 zinc finger; Region: zf-CHC2; cl15369 167539001950 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 167539001951 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 167539001952 active site 167539001953 metal binding site [ion binding]; metal-binding site 167539001954 interdomain interaction site; other site 167539001955 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 167539001956 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 167539001957 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 167539001958 active site 167539001959 DNA binding site [nucleotide binding] 167539001960 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 167539001961 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167539001962 Catalytic site [active] 167539001963 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 167539001964 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 167539001965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539001966 S-adenosylmethionine binding site [chemical binding]; other site 167539001967 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 167539001968 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167539001969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167539001970 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 167539001971 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 167539001972 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 167539001973 alpha subunit interface [polypeptide binding]; other site 167539001974 TPP binding site [chemical binding]; other site 167539001975 heterodimer interface [polypeptide binding]; other site 167539001976 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167539001977 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 167539001978 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167539001979 Protein export membrane protein; Region: SecD_SecF; cl14618 167539001980 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 167539001981 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167539001982 Protein export membrane protein; Region: SecD_SecF; cl14618 167539001983 Domain of unknown function DUF20; Region: UPF0118; pfam01594 167539001984 Psb28 protein; Region: Psb28; cl04326 167539001985 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 167539001986 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 167539001987 active site residue [active] 167539001988 GUN4-like; Region: GUN4; pfam05419 167539001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 167539001990 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 167539001991 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 167539001992 active site 167539001993 catalytic site [active] 167539001994 substrate binding site [chemical binding]; other site 167539001995 histidyl-tRNA synthetase; Region: hisS; TIGR00442 167539001996 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 167539001997 dimer interface [polypeptide binding]; other site 167539001998 motif 1; other site 167539001999 active site 167539002000 motif 2; other site 167539002001 motif 3; other site 167539002002 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 167539002003 anticodon binding site; other site 167539002004 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 167539002005 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 167539002006 Photosystem II protein; Region: PSII; cl08223 167539002007 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 167539002008 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 167539002009 putative GSH binding site (G-site) [chemical binding]; other site 167539002010 active site cysteine [active] 167539002011 putative C-terminal domain interface [polypeptide binding]; other site 167539002012 putative dimer interface [polypeptide binding]; other site 167539002013 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 167539002014 putative N-terminal domain interface [polypeptide binding]; other site 167539002015 putative dimer interface [polypeptide binding]; other site 167539002016 putative substrate binding pocket (H-site) [chemical binding]; other site 167539002017 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 167539002018 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 167539002019 putative NAD(P) binding site [chemical binding]; other site 167539002020 active site 167539002021 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167539002022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002024 NAD(P) binding site [chemical binding]; other site 167539002025 active site 167539002026 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 167539002027 Mechanosensitive ion channel; Region: MS_channel; pfam00924 167539002028 Isochorismatase family; Region: Isochorismatase; pfam00857 167539002029 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 167539002030 catalytic triad [active] 167539002031 dimer interface [polypeptide binding]; other site 167539002032 conserved cis-peptide bond; other site 167539002033 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167539002034 metal binding site 2 [ion binding]; metal-binding site 167539002035 putative DNA binding helix; other site 167539002036 metal binding site 1 [ion binding]; metal-binding site 167539002037 dimer interface [polypeptide binding]; other site 167539002038 structural Zn2+ binding site [ion binding]; other site 167539002039 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 167539002040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539002041 FeS/SAM binding site; other site 167539002042 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 167539002043 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 167539002044 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 167539002045 Phosphotransferase enzyme family; Region: APH; pfam01636 167539002046 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539002047 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 167539002048 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167539002049 homodimer interface [polypeptide binding]; other site 167539002050 substrate-cofactor binding pocket; other site 167539002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002052 catalytic residue [active] 167539002053 Homoserine O-succinyltransferase; Region: HTS; pfam04204 167539002054 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 167539002055 proposed active site lysine [active] 167539002056 conserved cys residue [active] 167539002057 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 167539002058 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167539002059 Sulfate transporter family; Region: Sulfate_transp; cl15842 167539002060 Sulfate transporter family; Region: Sulfate_transp; cl15842 167539002061 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167539002062 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167539002063 FAD binding domain; Region: FAD_binding_4; pfam01565 167539002064 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 167539002065 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167539002066 putative active site [active] 167539002067 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 167539002068 putative active site [active] 167539002069 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167539002070 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167539002071 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167539002072 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002073 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167539002074 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002075 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167539002076 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 167539002077 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 167539002078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539002079 S-adenosylmethionine binding site [chemical binding]; other site 167539002080 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167539002081 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167539002082 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167539002083 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167539002084 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167539002085 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167539002086 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 167539002087 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 167539002088 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 167539002089 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 167539002090 DevC protein; Region: devC; TIGR01185 167539002091 FtsX-like permease family; Region: FtsX; cl15850 167539002092 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 167539002093 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 167539002094 Walker A/P-loop; other site 167539002095 ATP binding site [chemical binding]; other site 167539002096 Q-loop/lid; other site 167539002097 ABC transporter signature motif; other site 167539002098 Walker B; other site 167539002099 D-loop; other site 167539002100 H-loop/switch region; other site 167539002101 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167539002102 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 167539002103 Probable Catalytic site; other site 167539002104 metal-binding site 167539002105 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 167539002106 rRNA interaction site [nucleotide binding]; other site 167539002107 S8 interaction site; other site 167539002108 putative laminin-1 binding site; other site 167539002109 elongation factor Ts; Reviewed; Region: tsf; PRK12332 167539002110 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 167539002111 Elongation factor TS; Region: EF_TS; pfam00889 167539002112 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 167539002113 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 167539002114 generic binding surface II; other site 167539002115 ssDNA binding site; other site 167539002116 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539002117 ATP binding site [chemical binding]; other site 167539002118 putative Mg++ binding site [ion binding]; other site 167539002119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539002120 nucleotide binding region [chemical binding]; other site 167539002121 ATP-binding site [chemical binding]; other site 167539002122 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 167539002123 sulfite reductase subunit beta; Provisional; Region: PRK13504 167539002124 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167539002125 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167539002126 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 167539002127 geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093 167539002128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002129 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 167539002130 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 167539002131 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 167539002132 G1 box; other site 167539002133 putative GEF interaction site [polypeptide binding]; other site 167539002134 GTP/Mg2+ binding site [chemical binding]; other site 167539002135 Switch I region; other site 167539002136 G2 box; other site 167539002137 G3 box; other site 167539002138 Switch II region; other site 167539002139 G4 box; other site 167539002140 G5 box; other site 167539002141 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 167539002142 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 167539002143 Domain of unknown function (DUF309); Region: DUF309; cl00667 167539002144 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 167539002145 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 167539002146 Walker A/P-loop; other site 167539002147 ATP binding site [chemical binding]; other site 167539002148 Q-loop/lid; other site 167539002149 ABC transporter signature motif; other site 167539002150 Walker B; other site 167539002151 D-loop; other site 167539002152 H-loop/switch region; other site 167539002153 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 167539002154 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 167539002155 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 167539002156 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 167539002157 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 167539002158 substrate binding site [chemical binding]; other site 167539002159 hexamer interface [polypeptide binding]; other site 167539002160 metal binding site [ion binding]; metal-binding site 167539002161 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 167539002162 putative active site [active] 167539002163 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 167539002164 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 167539002165 tRNA; other site 167539002166 putative tRNA binding site [nucleotide binding]; other site 167539002167 putative NADP binding site [chemical binding]; other site 167539002168 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 167539002169 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 167539002170 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 167539002171 ligand binding site; other site 167539002172 oligomer interface; other site 167539002173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167539002174 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 167539002175 dimer interface [polypeptide binding]; other site 167539002176 N-terminal domain interface [polypeptide binding]; other site 167539002177 sulfate 1 binding site; other site 167539002178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002179 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167539002180 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 167539002181 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 167539002182 putative active site [active] 167539002183 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 167539002184 Dehydratase family; Region: ILVD_EDD; cl00340 167539002185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 167539002186 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167539002187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539002189 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 167539002190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002191 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167539002192 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 167539002193 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 167539002194 putative active site [active] 167539002195 catalytic triad [active] 167539002196 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 167539002197 hypothetical protein; Provisional; Region: PRK08185 167539002198 intersubunit interface [polypeptide binding]; other site 167539002199 active site 167539002200 zinc binding site [ion binding]; other site 167539002201 Na+ binding site [ion binding]; other site 167539002202 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 167539002203 active site 167539002204 intersubunit interface [polypeptide binding]; other site 167539002205 catalytic residue [active] 167539002206 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167539002207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002208 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 167539002209 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 167539002210 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 167539002211 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 167539002212 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 167539002213 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 167539002214 active site 167539002215 tartrate dehydrogenase; Provisional; Region: PRK08194 167539002216 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167539002217 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 167539002218 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 167539002219 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 167539002220 trimer interface [polypeptide binding]; other site 167539002221 active site 167539002222 UDP-GlcNAc binding site [chemical binding]; other site 167539002223 lipid binding site [chemical binding]; lipid-binding site 167539002224 gamma-glutamyl kinase; Provisional; Region: PRK05429 167539002225 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 167539002226 nucleotide binding site [chemical binding]; other site 167539002227 homotetrameric interface [polypeptide binding]; other site 167539002228 putative phosphate binding site [ion binding]; other site 167539002229 putative allosteric binding site; other site 167539002230 PUA domain; Region: PUA; cl00607 167539002231 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 167539002232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539002233 active site 167539002234 motif I; other site 167539002235 motif II; other site 167539002236 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 167539002237 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 167539002238 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 167539002239 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539002240 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 167539002241 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 167539002242 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 167539002243 catalytic residues [active] 167539002244 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539002245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002246 NAD(P) binding site [chemical binding]; other site 167539002247 active site 167539002248 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 167539002249 Domain of unknown function (DUF296); Region: DUF296; cl00720 167539002250 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 167539002251 GSH binding site [chemical binding]; other site 167539002252 catalytic residues [active] 167539002253 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 167539002254 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167539002255 NADH(P)-binding; Region: NAD_binding_10; pfam13460 167539002256 NAD(P) binding site [chemical binding]; other site 167539002257 putative active site [active] 167539002258 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 167539002259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167539002260 minor groove reading motif; other site 167539002261 helix-hairpin-helix signature motif; other site 167539002262 substrate binding pocket [chemical binding]; other site 167539002263 active site 167539002264 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 167539002265 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 167539002266 Walker A/P-loop; other site 167539002267 ATP binding site [chemical binding]; other site 167539002268 Q-loop/lid; other site 167539002269 ABC transporter signature motif; other site 167539002270 Walker B; other site 167539002271 D-loop; other site 167539002272 H-loop/switch region; other site 167539002273 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 167539002274 Ferritin-like domain; Region: Ferritin; pfam00210 167539002275 ferroxidase diiron center [ion binding]; other site 167539002276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167539002277 Helix-turn-helix domains; Region: HTH; cl00088 167539002278 putative switch regulator; other site 167539002279 non-specific DNA interactions [nucleotide binding]; other site 167539002280 DNA binding site [nucleotide binding] 167539002281 sequence specific DNA binding site [nucleotide binding]; other site 167539002282 putative cAMP binding site [chemical binding]; other site 167539002283 Photosystem II protein; Region: PSII; cl08223 167539002284 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 167539002285 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 167539002286 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 167539002287 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167539002288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002289 Walker A/P-loop; other site 167539002290 ATP binding site [chemical binding]; other site 167539002291 Q-loop/lid; other site 167539002292 ABC transporter signature motif; other site 167539002293 Walker B; other site 167539002294 D-loop; other site 167539002295 H-loop/switch region; other site 167539002296 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 167539002297 [2Fe-2S] cluster binding site [ion binding]; other site 167539002298 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167539002299 Photosystem II protein; Region: PSII; cl08223 167539002300 L-asparaginase II; Region: Asparaginase_II; cl01842 167539002301 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 167539002302 Oligomerisation domain; Region: Oligomerisation; cl00519 167539002303 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 167539002304 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 167539002305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167539002306 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539002307 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 167539002308 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167539002309 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539002310 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 167539002311 IMP binding site; other site 167539002312 dimer interface [polypeptide binding]; other site 167539002313 interdomain contacts; other site 167539002314 partial ornithine binding site; other site 167539002315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539002316 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167539002317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002318 Walker A/P-loop; other site 167539002319 ATP binding site [chemical binding]; other site 167539002320 Q-loop/lid; other site 167539002321 ABC transporter signature motif; other site 167539002322 Walker B; other site 167539002323 D-loop; other site 167539002324 H-loop/switch region; other site 167539002325 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539002326 RNA binding surface [nucleotide binding]; other site 167539002327 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 167539002328 substrate binding site [chemical binding]; other site 167539002329 dimer interface [polypeptide binding]; other site 167539002330 catalytic triad [active] 167539002331 dihydropteroate synthase; Region: DHPS; TIGR01496 167539002332 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 167539002333 substrate binding pocket [chemical binding]; other site 167539002334 dimer interface [polypeptide binding]; other site 167539002335 inhibitor binding site; inhibition site 167539002336 magnesium chelatase subunit H; Provisional; Region: PRK12493 167539002337 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 167539002338 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167539002339 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167539002340 dihydrodipicolinate reductase; Provisional; Region: PRK00048 167539002341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002342 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 167539002343 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 167539002344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002346 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 167539002347 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 167539002348 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 167539002349 ABC transporter; Provisional; Region: PTZ00243 167539002350 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 167539002351 PetN; Region: PetN; cl15376 167539002352 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 167539002353 Clp protease; Region: CLP_protease; pfam00574 167539002354 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539002355 oligomer interface [polypeptide binding]; other site 167539002356 active site residues [active] 167539002357 cell division protein; Validated; Region: ftsH; CHL00176 167539002358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002360 Walker A motif; other site 167539002361 ATP binding site [chemical binding]; other site 167539002362 Walker B motif; other site 167539002363 arginine finger; other site 167539002364 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539002365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167539002366 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 167539002367 FtsX-like permease family; Region: FtsX; cl15850 167539002368 pyruvate kinase; Provisional; Region: PRK06354 167539002369 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 167539002370 domain interfaces; other site 167539002371 active site 167539002372 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167539002373 YGGT family; Region: YGGT; cl00508 167539002374 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 167539002375 threonine dehydratase; Reviewed; Region: PRK09224 167539002376 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 167539002377 tetramer interface [polypeptide binding]; other site 167539002378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002379 catalytic residue [active] 167539002380 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 167539002381 putative Ile/Val binding site [chemical binding]; other site 167539002382 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 167539002383 putative Ile/Val binding site [chemical binding]; other site 167539002384 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 167539002385 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 167539002386 TPP-binding site; other site 167539002387 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167539002388 PYR/PP interface [polypeptide binding]; other site 167539002389 dimer interface [polypeptide binding]; other site 167539002390 TPP binding site [chemical binding]; other site 167539002391 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167539002392 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 167539002393 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 167539002394 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 167539002395 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167539002396 catalytic triad [active] 167539002397 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 167539002398 heat shock protein 90; Provisional; Region: PRK05218 167539002399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 167539002400 Ferredoxin [Energy production and conversion]; Region: COG1146 167539002401 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167539002402 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 167539002403 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 167539002404 dimer interface [polypeptide binding]; other site 167539002405 motif 1; other site 167539002406 active site 167539002407 motif 2; other site 167539002408 motif 3; other site 167539002409 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 167539002410 active site 167539002411 dimerization interface [polypeptide binding]; other site 167539002412 molecular chaperone DnaK; Provisional; Region: PRK13410 167539002413 chaperone protein DnaJ; Provisional; Region: PRK14299 167539002414 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539002415 HSP70 interaction site [polypeptide binding]; other site 167539002416 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167539002417 substrate binding site [polypeptide binding]; other site 167539002418 dimer interface [polypeptide binding]; other site 167539002419 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 167539002420 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 167539002421 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 167539002422 putative active site [active] 167539002423 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167539002424 active site 167539002425 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 167539002426 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 167539002427 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 167539002428 dimerization interface [polypeptide binding]; other site 167539002429 active site 167539002430 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 167539002431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002432 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 167539002433 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 167539002434 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 167539002435 active site 167539002436 substrate binding site [chemical binding]; other site 167539002437 cosubstrate binding site; other site 167539002438 catalytic site [active] 167539002439 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 167539002440 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 167539002441 active site 167539002442 dimer interface [polypeptide binding]; other site 167539002443 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 167539002444 dimer interface [polypeptide binding]; other site 167539002445 active site 167539002446 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 167539002447 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 167539002448 HIGH motif; other site 167539002449 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167539002450 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539002451 active site 167539002452 KMSKS motif; other site 167539002453 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 167539002454 tRNA binding surface [nucleotide binding]; other site 167539002455 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 167539002456 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 167539002457 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 167539002458 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539002459 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 167539002460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539002461 catalytic residue [active] 167539002462 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 167539002463 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539002464 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 167539002465 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539002466 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 167539002467 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 167539002468 active site 167539002469 (T/H)XGH motif; other site 167539002470 Flavin Reductases; Region: FlaRed; cl00801 167539002471 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 167539002472 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 167539002473 GIY-YIG motif/motif A; other site 167539002474 active site 167539002475 catalytic site [active] 167539002476 putative DNA binding site [nucleotide binding]; other site 167539002477 metal binding site [ion binding]; metal-binding site 167539002478 UvrB/uvrC motif; Region: UVR; pfam02151 167539002479 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 167539002480 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 167539002481 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 167539002482 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167539002483 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 167539002484 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167539002485 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 167539002486 homodimer interface [polypeptide binding]; other site 167539002487 substrate-cofactor binding pocket; other site 167539002488 catalytic residue [active] 167539002489 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 167539002490 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 167539002491 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 167539002492 substrate binding pocket [chemical binding]; other site 167539002493 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 167539002494 B12 binding site [chemical binding]; other site 167539002495 cobalt ligand [ion binding]; other site 167539002496 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 167539002497 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 167539002498 ATP adenylyltransferase; Region: ATP_transf; pfam09830 167539002499 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539002500 HSP70 interaction site [polypeptide binding]; other site 167539002501 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 167539002502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 167539002503 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 167539002504 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 167539002505 putative tRNA-binding site [nucleotide binding]; other site 167539002506 B3/4 domain; Region: B3_4; cl11458 167539002507 tRNA synthetase B5 domain; Region: B5; cl08394 167539002508 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 167539002509 dimer interface [polypeptide binding]; other site 167539002510 motif 1; other site 167539002511 motif 3; other site 167539002512 motif 2; other site 167539002513 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 167539002514 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 167539002515 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 167539002516 RNB domain; Region: RNB; pfam00773 167539002517 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167539002518 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 167539002519 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 167539002520 active site 167539002521 HIGH motif; other site 167539002522 KMSKS motif; other site 167539002523 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 167539002524 tRNA binding surface [nucleotide binding]; other site 167539002525 anticodon binding site; other site 167539002526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 167539002527 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 167539002528 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 167539002529 homotrimer interface [polypeptide binding]; other site 167539002530 Walker A motif; other site 167539002531 GTP binding site [chemical binding]; other site 167539002532 Walker B motif; other site 167539002533 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167539002534 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 167539002535 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167539002536 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 167539002537 dimer interface [polypeptide binding]; other site 167539002538 decamer (pentamer of dimers) interface [polypeptide binding]; other site 167539002539 catalytic triad [active] 167539002540 peroxidatic and resolving cysteines [active] 167539002541 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 167539002542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002543 Walker A motif; other site 167539002544 ATP binding site [chemical binding]; other site 167539002545 Walker B motif; other site 167539002546 arginine finger; other site 167539002547 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539002548 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 167539002549 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 167539002550 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167539002551 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167539002552 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 167539002553 DHH family; Region: DHH; pfam01368 167539002554 DHHA1 domain; Region: DHHA1; pfam02272 167539002555 Flagellin N-methylase; Region: FliB; cl00497 167539002556 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167539002557 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167539002558 Exoribonuclease R [Transcription]; Region: VacB; COG0557 167539002559 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167539002560 RNB domain; Region: RNB; pfam00773 167539002561 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 167539002562 RNA binding site [nucleotide binding]; other site 167539002563 aromatic acid decarboxylase; Validated; Region: PRK05920 167539002564 Flavoprotein; Region: Flavoprotein; cl08021 167539002565 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 167539002566 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 167539002567 dinuclear metal binding motif [ion binding]; other site 167539002568 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539002569 catalytic loop [active] 167539002570 iron binding site [ion binding]; other site 167539002571 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 167539002572 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 167539002573 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 167539002574 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 167539002575 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 167539002576 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 167539002577 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 167539002578 putative active site [active] 167539002579 substrate binding site [chemical binding]; other site 167539002580 putative cosubstrate binding site; other site 167539002581 catalytic site [active] 167539002582 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 167539002583 substrate binding site [chemical binding]; other site 167539002584 Integral membrane protein TerC family; Region: TerC; cl10468 167539002585 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 167539002586 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 167539002587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539002588 ATP binding site [chemical binding]; other site 167539002589 putative Mg++ binding site [ion binding]; other site 167539002590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539002591 nucleotide binding region [chemical binding]; other site 167539002592 ATP-binding site [chemical binding]; other site 167539002593 TRCF domain; Region: TRCF; cl04088 167539002594 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167539002595 DoxX; Region: DoxX; cl00976 167539002596 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 167539002597 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 167539002598 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539002599 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 167539002600 active site 167539002601 dimer interface [polypeptide binding]; other site 167539002602 metal binding site [ion binding]; metal-binding site 167539002603 Uncharacterized conserved protein [Function unknown]; Region: COG1565 167539002604 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 167539002605 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 167539002606 Repair protein; Region: Repair_PSII; cl01535 167539002607 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 167539002608 active site 167539002609 metal binding site [ion binding]; metal-binding site 167539002610 Quinolinate synthetase A protein; Region: NadA; cl00420 167539002611 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167539002612 C-terminal peptidase (prc); Region: prc; TIGR00225 167539002613 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167539002614 protein binding site [polypeptide binding]; other site 167539002615 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167539002616 Catalytic dyad [active] 167539002617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 167539002618 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167539002619 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167539002620 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 167539002621 Fe-S cluster binding site [ion binding]; other site 167539002622 active site 167539002623 aspartate aminotransferase; Provisional; Region: PRK05764 167539002624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002626 homodimer interface [polypeptide binding]; other site 167539002627 catalytic residue [active] 167539002628 NMT1-like family; Region: NMT1_2; cl15260 167539002629 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 167539002630 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 167539002631 Walker A/P-loop; other site 167539002632 ATP binding site [chemical binding]; other site 167539002633 Q-loop/lid; other site 167539002634 ABC transporter signature motif; other site 167539002635 Walker B; other site 167539002636 D-loop; other site 167539002637 H-loop/switch region; other site 167539002638 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167539002639 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 167539002640 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 167539002641 active site 167539002642 catalytic triad [active] 167539002643 oxyanion hole [active] 167539002644 Integral membrane protein DUF92; Region: DUF92; cl00793 167539002645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 167539002646 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 167539002647 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 167539002648 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 167539002649 Walker A/P-loop; other site 167539002650 ATP binding site [chemical binding]; other site 167539002651 ABC transporter; Region: ABC_tran; pfam00005 167539002652 Q-loop/lid; other site 167539002653 ABC transporter signature motif; other site 167539002654 Walker B; other site 167539002655 D-loop; other site 167539002656 H-loop/switch region; other site 167539002657 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 167539002658 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 167539002659 dimerization interface [polypeptide binding]; other site 167539002660 domain crossover interface; other site 167539002661 redox-dependent activation switch; other site 167539002662 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 167539002663 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 167539002664 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 167539002665 G1 box; other site 167539002666 putative GEF interaction site [polypeptide binding]; other site 167539002667 GTP/Mg2+ binding site [chemical binding]; other site 167539002668 Switch I region; other site 167539002669 G2 box; other site 167539002670 G3 box; other site 167539002671 Switch II region; other site 167539002672 G4 box; other site 167539002673 G5 box; other site 167539002674 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 167539002675 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 167539002676 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 167539002677 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 167539002678 lipoprotein signal peptidase; Provisional; Region: PRK14787 167539002679 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167539002680 G1 box; other site 167539002681 GTP/Mg2+ binding site [chemical binding]; other site 167539002682 Switch I region; other site 167539002683 G2 box; other site 167539002684 Switch II region; other site 167539002685 G3 box; other site 167539002686 G4 box; other site 167539002687 G5 box; other site 167539002688 Domain of unknown function (DUF697); Region: DUF697; cl12064 167539002689 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539002690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539002691 catalytic residue [active] 167539002692 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 167539002693 nucleoside/Zn binding site; other site 167539002694 dimer interface [polypeptide binding]; other site 167539002695 catalytic motif [active] 167539002696 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167539002697 homodimer interface [polypeptide binding]; other site 167539002698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539002699 catalytic residue [active] 167539002700 glutamine synthetase, type I; Region: GlnA; TIGR00653 167539002701 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 167539002702 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 167539002703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539002704 S-adenosylmethionine binding site [chemical binding]; other site 167539002705 acetyl-CoA synthetase; Provisional; Region: PRK00174 167539002706 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 167539002707 AMP-binding enzyme; Region: AMP-binding; cl15778 167539002708 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539002709 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167539002710 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167539002711 substrate binding pocket [chemical binding]; other site 167539002712 chain length determination region; other site 167539002713 substrate-Mg2+ binding site; other site 167539002714 catalytic residues [active] 167539002715 aspartate-rich region 1; other site 167539002716 active site lid residues [active] 167539002717 aspartate-rich region 2; other site 167539002718 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 167539002719 AMIN domain; Region: AMIN; pfam11741 167539002720 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 167539002721 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 167539002722 active site 167539002723 metal binding site [ion binding]; metal-binding site 167539002724 Predicted amidohydrolase [General function prediction only]; Region: COG0388 167539002725 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 167539002726 putative active site [active] 167539002727 catalytic triad [active] 167539002728 dimer interface [polypeptide binding]; other site 167539002729 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 167539002730 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 167539002731 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 167539002732 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 167539002733 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 167539002734 hinge; other site 167539002735 active site 167539002736 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 167539002737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 167539002738 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 167539002739 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 167539002740 Substrate binding site; other site 167539002741 Mg++ binding site; other site 167539002742 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 167539002743 active site 167539002744 substrate binding site [chemical binding]; other site 167539002745 CoA binding site [chemical binding]; other site 167539002746 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167539002747 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 167539002748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539002749 glycogen synthase; Provisional; Region: glgA; PRK00654 167539002750 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 167539002751 ADP-binding pocket [chemical binding]; other site 167539002752 homodimer interface [polypeptide binding]; other site 167539002753 naphthoate synthase; Region: PLN02921 167539002754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 167539002755 substrate binding site [chemical binding]; other site 167539002756 oxyanion hole (OAH) forming residues; other site 167539002757 trimer interface [polypeptide binding]; other site 167539002758 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 167539002759 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 167539002760 dimer interface [polypeptide binding]; other site 167539002761 tetramer interface [polypeptide binding]; other site 167539002762 PYR/PP interface [polypeptide binding]; other site 167539002763 TPP binding site [chemical binding]; other site 167539002764 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 167539002765 TPP-binding site; other site 167539002766 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539002767 Catalytic site [active] 167539002768 Protein of unknown function (DUF760); Region: DUF760; pfam05542 167539002769 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 167539002770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167539002771 ABC-ATPase subunit interface; other site 167539002772 dimer interface [polypeptide binding]; other site 167539002773 putative PBP binding regions; other site 167539002774 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167539002775 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 167539002776 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 167539002777 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 167539002778 metal binding site [ion binding]; metal-binding site 167539002779 Domain of unknown function (DUF697); Region: DUF697; cl12064 167539002780 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 167539002781 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 167539002782 active site 167539002783 HIGH motif; other site 167539002784 dimer interface [polypeptide binding]; other site 167539002785 KMSKS motif; other site 167539002786 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 167539002787 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 167539002788 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 167539002789 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 167539002790 active site 167539002791 dimer interface [polypeptide binding]; other site 167539002792 motif 1; other site 167539002793 motif 2; other site 167539002794 motif 3; other site 167539002795 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 167539002796 anticodon binding site; other site 167539002797 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 167539002798 glucokinase, proteobacterial type; Region: glk; TIGR00749 167539002799 homoserine kinase; Provisional; Region: PRK01212 167539002800 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167539002801 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167539002802 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 167539002803 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167539002804 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 167539002805 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 167539002806 active site 167539002807 Zn binding site [ion binding]; other site 167539002808 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 167539002809 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539002810 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 167539002811 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 167539002812 putative catalytic cysteine [active] 167539002813 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 167539002814 Family of unknown function (DUF490); Region: DUF490; pfam04357 167539002815 Family of unknown function (DUF490); Region: DUF490; pfam04357 167539002816 Protein of function (DUF2518); Region: DUF2518; pfam10726 167539002817 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 167539002818 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 167539002819 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 167539002820 glycogen branching enzyme; Provisional; Region: PRK05402 167539002821 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 167539002822 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 167539002823 active site 167539002824 catalytic site [active] 167539002825 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 167539002826 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 167539002827 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 167539002828 substrate binding site [chemical binding]; other site 167539002829 active site 167539002830 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167539002831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539002832 NAD(P) binding site [chemical binding]; other site 167539002833 active site 167539002834 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 167539002835 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167539002836 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002837 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002839 Walker A motif; other site 167539002840 ATP binding site [chemical binding]; other site 167539002841 Walker B motif; other site 167539002842 arginine finger; other site 167539002843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002844 Walker A motif; other site 167539002845 ATP binding site [chemical binding]; other site 167539002846 Walker B motif; other site 167539002847 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167539002848 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167539002849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539002850 active site 167539002851 phosphorylation site [posttranslational modification] 167539002852 intermolecular recognition site; other site 167539002853 dimerization interface [polypeptide binding]; other site 167539002854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539002855 DNA binding site [nucleotide binding] 167539002856 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 167539002857 putative GSH binding site [chemical binding]; other site 167539002858 catalytic residues [active] 167539002859 BolA-like protein; Region: BolA; cl00386 167539002860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167539002861 putative acyl-acceptor binding pocket; other site 167539002862 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 167539002863 active site 167539002864 hydrophilic channel; other site 167539002865 dimerization interface [polypeptide binding]; other site 167539002866 catalytic residues [active] 167539002867 active site lid [active] 167539002868 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 167539002869 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 167539002870 Phospholipid methyltransferase; Region: PEMT; cl00763 167539002871 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 167539002872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002873 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 167539002874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002875 Family description; Region: UvrD_C_2; cl15862 167539002876 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 167539002877 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 167539002878 ATP binding site [chemical binding]; other site 167539002879 Mg++ binding site [ion binding]; other site 167539002880 motif III; other site 167539002881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539002882 nucleotide binding region [chemical binding]; other site 167539002883 ATP-binding site [chemical binding]; other site 167539002884 DbpA RNA binding domain; Region: DbpA; pfam03880 167539002885 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539002886 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167539002887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002888 Q-loop/lid; other site 167539002889 ABC transporter signature motif; other site 167539002890 Walker B; other site 167539002891 D-loop; other site 167539002892 H-loop/switch region; other site 167539002893 PsbP; Region: PsbP; cl03356 167539002894 RecR protein; Region: RecR; pfam02132 167539002895 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 167539002896 putative active site [active] 167539002897 putative metal-binding site [ion binding]; other site 167539002898 tetramer interface [polypeptide binding]; other site 167539002899 lipoyl synthase; Provisional; Region: PRK12928 167539002900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539002901 FeS/SAM binding site; other site 167539002902 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 167539002903 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 167539002904 active site residue [active] 167539002905 biotin synthase; Region: bioB; TIGR00433 167539002906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539002907 FeS/SAM binding site; other site 167539002908 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 167539002909 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 167539002910 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 167539002911 catalytic residue [active] 167539002912 putative FPP diphosphate binding site; other site 167539002913 putative FPP binding hydrophobic cleft; other site 167539002914 dimer interface [polypeptide binding]; other site 167539002915 putative IPP diphosphate binding site; other site 167539002916 TIGR00159 family protein; Region: TIGR00159 167539002917 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 167539002918 diaminopimelate decarboxylase; Region: lysA; TIGR01048 167539002919 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 167539002920 active site 167539002921 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539002922 substrate binding site [chemical binding]; other site 167539002923 catalytic residues [active] 167539002924 dimer interface [polypeptide binding]; other site 167539002925 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 167539002926 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 167539002927 Clp protease ATP binding subunit; Region: clpC; CHL00095 167539002928 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002929 Clp amino terminal domain; Region: Clp_N; pfam02861 167539002930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002931 Walker A motif; other site 167539002932 ATP binding site [chemical binding]; other site 167539002933 Walker B motif; other site 167539002934 arginine finger; other site 167539002935 UvrB/uvrC motif; Region: UVR; pfam02151 167539002936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539002937 Walker A motif; other site 167539002938 ATP binding site [chemical binding]; other site 167539002939 Walker B motif; other site 167539002940 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167539002941 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 167539002942 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 167539002943 putative active site [active] 167539002944 metal binding site [ion binding]; metal-binding site 167539002945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167539002946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167539002947 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 167539002948 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539002949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539002950 catalytic residue [active] 167539002951 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 167539002952 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167539002953 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539002954 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 167539002955 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 167539002956 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 167539002957 active site 167539002958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 167539002959 Helper component proteinase; Region: Peptidase_C6; pfam00851 167539002960 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 167539002961 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 167539002962 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 167539002963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539002964 active site 167539002965 adaptive-response sensory kinase; Validated; Region: PRK09303 167539002966 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167539002967 tetramer interface [polypeptide binding]; other site 167539002968 dimer interface [polypeptide binding]; other site 167539002969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 167539002970 dimer interface [polypeptide binding]; other site 167539002971 phosphorylation site [posttranslational modification] 167539002972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539002973 ATP binding site [chemical binding]; other site 167539002974 Mg2+ binding site [ion binding]; other site 167539002975 G-X-G motif; other site 167539002976 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167539002977 hydrophobic ligand binding site; other site 167539002978 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 167539002979 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 167539002980 dimerization interface [polypeptide binding]; other site 167539002981 FAD binding pocket [chemical binding]; other site 167539002982 FAD binding motif [chemical binding]; other site 167539002983 catalytic residues [active] 167539002984 NAD binding pocket [chemical binding]; other site 167539002985 phosphate binding motif [ion binding]; other site 167539002986 beta-alpha-beta structure motif; other site 167539002987 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 167539002988 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 167539002989 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 167539002990 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 167539002991 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 167539002992 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 167539002993 catalytic triad [active] 167539002994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539002995 Family description; Region: UvrD_C_2; cl15862 167539002996 Divergent PAP2 family; Region: DUF212; cl00855 167539002997 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167539002998 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167539002999 substrate binding pocket [chemical binding]; other site 167539003000 chain length determination region; other site 167539003001 substrate-Mg2+ binding site; other site 167539003002 catalytic residues [active] 167539003003 aspartate-rich region 1; other site 167539003004 active site lid residues [active] 167539003005 aspartate-rich region 2; other site 167539003006 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 167539003007 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 167539003008 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 167539003009 homodimer interface [polypeptide binding]; other site 167539003010 NADP binding site [chemical binding]; other site 167539003011 substrate binding site [chemical binding]; other site 167539003012 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 167539003013 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 167539003014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167539003015 Zn2+ binding site [ion binding]; other site 167539003016 Mg2+ binding site [ion binding]; other site 167539003017 putative methanogenesis marker protein 2; Region: methan_mark_2; TIGR03267 167539003018 2-isopropylmalate synthase; Validated; Region: PRK00915 167539003019 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 167539003020 active site 167539003021 catalytic residues [active] 167539003022 metal binding site [ion binding]; metal-binding site 167539003023 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 167539003024 Uncharacterized conserved protein [Function unknown]; Region: COG1543 167539003025 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 167539003026 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167539003027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003028 DNA gyrase subunit A; Validated; Region: PRK05560 167539003029 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 167539003030 CAP-like domain; other site 167539003031 active site 167539003032 primary dimer interface [polypeptide binding]; other site 167539003033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167539003038 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 167539003039 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 167539003040 active site 167539003041 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 167539003042 catalytic residues [active] 167539003043 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167539003044 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167539003045 putative active site [active] 167539003046 oxyanion strand; other site 167539003047 catalytic triad [active] 167539003048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539003049 S-adenosylmethionine binding site [chemical binding]; other site 167539003050 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 167539003051 Cytochrome c; Region: Cytochrom_C; cl11414 167539003052 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167539003053 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 167539003054 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539003055 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 167539003056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003057 Walker A motif; other site 167539003058 ATP binding site [chemical binding]; other site 167539003059 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 167539003060 active site 167539003061 putative DNA-binding cleft [nucleotide binding]; other site 167539003062 dimer interface [polypeptide binding]; other site 167539003063 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 167539003064 Fe-S metabolism associated domain; Region: SufE; cl00951 167539003065 homoserine dehydrogenase; Provisional; Region: PRK06349 167539003066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003067 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 167539003068 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 167539003069 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 167539003070 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 167539003071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 167539003072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167539003073 dimer interface [polypeptide binding]; other site 167539003074 conserved gate region; other site 167539003075 putative PBP binding loops; other site 167539003076 ABC-ATPase subunit interface; other site 167539003077 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167539003078 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167539003079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167539003080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167539003081 putative substrate translocation pore; other site 167539003082 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167539003083 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 167539003084 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167539003085 substrate binding site [chemical binding]; other site 167539003086 ATP binding site [chemical binding]; other site 167539003087 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167539003088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003090 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167539003091 Photosystem II protein; Region: PSII; cl08223 167539003092 Photosystem II protein; Region: PSII; cl08223 167539003093 Photosystem II protein; Region: PSII; cl08223 167539003094 putative high light inducible protein; Region: PHA02337 167539003095 putative high light inducible protein; Region: PHA02337 167539003096 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 167539003097 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 167539003098 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 167539003099 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 167539003100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003101 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539003102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539003103 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 167539003104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167539003105 active site 167539003106 catalytic tetrad [active] 167539003107 PQ loop repeat; Region: PQ-loop; cl12056 167539003108 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167539003109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003110 Walker A/P-loop; other site 167539003111 ATP binding site [chemical binding]; other site 167539003112 Q-loop/lid; other site 167539003113 ABC transporter signature motif; other site 167539003114 Walker B; other site 167539003115 D-loop; other site 167539003116 H-loop/switch region; other site 167539003117 ABC transporter; Region: ABC_tran_2; pfam12848 167539003118 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 167539003119 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 167539003120 RNA/DNA binding site [nucleotide binding]; other site 167539003121 RRM dimerization site [polypeptide binding]; other site 167539003122 Membrane transport protein; Region: Mem_trans; cl09117 167539003123 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 167539003124 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 167539003125 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 167539003126 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167539003127 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167539003128 putative di-iron ligands [ion binding]; other site 167539003129 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167539003130 TIR domain; Region: TIR_2; cl15770 167539003131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539003132 active site 167539003133 omega-6 fatty acid desaturase; Region: PLN02505 167539003134 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167539003135 putative di-iron ligands [ion binding]; other site 167539003136 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167539003137 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 167539003138 catalytic residues [active] 167539003139 dimer interface [polypeptide binding]; other site 167539003140 RF-1 domain; Region: RF-1; cl02875 167539003141 Ion channel; Region: Ion_trans_2; cl11596 167539003142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003143 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 167539003144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003145 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 167539003146 GTP-binding protein YchF; Reviewed; Region: PRK09601 167539003147 YchF GTPase; Region: YchF; cd01900 167539003148 G1 box; other site 167539003149 GTP/Mg2+ binding site [chemical binding]; other site 167539003150 Switch I region; other site 167539003151 G2 box; other site 167539003152 Switch II region; other site 167539003153 G3 box; other site 167539003154 G4 box; other site 167539003155 G5 box; other site 167539003156 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 167539003157 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 167539003158 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 167539003159 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 167539003160 DNA polymerase I; Provisional; Region: PRK05755 167539003161 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 167539003162 active site 167539003163 metal binding site 1 [ion binding]; metal-binding site 167539003164 putative 5' ssDNA interaction site; other site 167539003165 metal binding site 3; metal-binding site 167539003166 metal binding site 2 [ion binding]; metal-binding site 167539003167 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 167539003168 putative DNA binding site [nucleotide binding]; other site 167539003169 putative metal binding site [ion binding]; other site 167539003170 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 167539003171 active site 167539003172 catalytic site [active] 167539003173 substrate binding site [chemical binding]; other site 167539003174 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 167539003175 active site 167539003176 DNA binding site [nucleotide binding] 167539003177 catalytic site [active] 167539003178 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 167539003179 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167539003180 active site 167539003181 HIGH motif; other site 167539003182 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167539003183 KMSKS motif; other site 167539003184 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167539003185 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 167539003186 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 167539003187 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 167539003188 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 167539003189 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 167539003190 dimer interface [polypeptide binding]; other site 167539003191 [2Fe-2S] cluster binding site [ion binding]; other site 167539003192 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 167539003193 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 167539003194 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 167539003195 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 167539003196 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 167539003197 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 167539003198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003199 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167539003200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539003201 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167539003202 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 167539003203 rRNA binding site [nucleotide binding]; other site 167539003204 predicted 30S ribosome binding site; other site 167539003205 Ycf39; Provisional; Region: ycf39; CHL00194 167539003206 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167539003207 NAD(P) binding site [chemical binding]; other site 167539003208 putative active site [active] 167539003209 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 167539003210 hydrolase; Region: PLN02578 167539003211 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167539003212 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 167539003213 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 167539003214 putative valine binding site [chemical binding]; other site 167539003215 dimer interface [polypeptide binding]; other site 167539003216 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 167539003217 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167539003218 active site 167539003219 Ycf4; Region: Ycf4; cl03567 167539003220 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 167539003221 pheophytin binding site; other site 167539003222 chlorophyll binding site; other site 167539003223 quinone binding site; other site 167539003224 Fe binding site [ion binding]; other site 167539003225 Photosystem II protein; Region: PSII; cl08223 167539003226 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 167539003227 Maf-like protein; Region: Maf; pfam02545 167539003228 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 167539003229 active site 167539003230 dimer interface [polypeptide binding]; other site 167539003231 cobyric acid synthase; Provisional; Region: PRK00784 167539003232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003234 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 167539003235 catalytic triad [active] 167539003236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539003237 catalytic loop [active] 167539003238 iron binding site [ion binding]; other site 167539003239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539003240 OpgC protein; Region: OpgC_C; cl00792 167539003241 CotH protein; Region: CotH; pfam08757 167539003242 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 167539003243 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 167539003244 putative metal binding residues [ion binding]; other site 167539003245 signature motif; other site 167539003246 dimer interface [polypeptide binding]; other site 167539003247 active site 167539003248 polyP binding site; other site 167539003249 substrate binding site [chemical binding]; other site 167539003250 acceptor-phosphate pocket; other site 167539003251 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 167539003252 dimer interface [polypeptide binding]; other site 167539003253 motif 1; other site 167539003254 active site 167539003255 motif 2; other site 167539003256 motif 3; other site 167539003257 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 167539003258 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 167539003259 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 167539003260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167539003261 DEAD-like helicases superfamily; Region: DEXDc; smart00487 167539003262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003263 ATP binding site [chemical binding]; other site 167539003264 putative Mg++ binding site [ion binding]; other site 167539003265 Z1 domain; Region: Z1; pfam10593 167539003266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003267 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167539003268 motif II; other site 167539003269 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539003270 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167539003271 TPP-binding site [chemical binding]; other site 167539003272 dimer interface [polypeptide binding]; other site 167539003273 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 167539003274 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167539003275 PYR/PP interface [polypeptide binding]; other site 167539003276 dimer interface [polypeptide binding]; other site 167539003277 TPP binding site [chemical binding]; other site 167539003278 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167539003279 extended (e) SDRs; Region: SDR_e; cd08946 167539003280 NAD(P) binding site [chemical binding]; other site 167539003281 active site 167539003282 substrate binding site [chemical binding]; other site 167539003283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003284 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 167539003285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003286 UDP-galactopyranose mutase; Region: GLF; pfam03275 167539003287 Photosystem II protein; Region: PSII; cl08223 167539003288 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 167539003289 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 167539003290 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 167539003291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167539003292 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539003293 EamA-like transporter family; Region: EamA; cl01037 167539003294 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 167539003295 EamA-like transporter family; Region: EamA; cl01037 167539003296 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 167539003297 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 167539003298 tandem repeat interface [polypeptide binding]; other site 167539003299 oligomer interface [polypeptide binding]; other site 167539003300 active site residues [active] 167539003301 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 167539003302 homotrimer interaction site [polypeptide binding]; other site 167539003303 active site 167539003304 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 167539003305 Ribonuclease P; Region: Ribonuclease_P; cl00457 167539003306 Bacterial PH domain; Region: DUF304; cl01348 167539003307 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 167539003308 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167539003309 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167539003310 Ycf46; Provisional; Region: ycf46; CHL00195 167539003311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539003312 Walker A motif; other site 167539003313 ATP binding site [chemical binding]; other site 167539003314 Walker B motif; other site 167539003315 arginine finger; other site 167539003316 seryl-tRNA synthetase; Provisional; Region: PRK05431 167539003317 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 167539003318 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 167539003319 dimer interface [polypeptide binding]; other site 167539003320 active site 167539003321 motif 1; other site 167539003322 motif 2; other site 167539003323 motif 3; other site 167539003324 RIP metalloprotease RseP; Region: TIGR00054 167539003325 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 167539003326 active site 167539003327 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 167539003328 protein binding site [polypeptide binding]; other site 167539003329 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 167539003330 putative substrate binding region [chemical binding]; other site 167539003331 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 167539003332 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 167539003333 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 167539003334 RNase E interface [polypeptide binding]; other site 167539003335 trimer interface [polypeptide binding]; other site 167539003336 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 167539003337 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 167539003338 RNase E interface [polypeptide binding]; other site 167539003339 trimer interface [polypeptide binding]; other site 167539003340 active site 167539003341 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 167539003342 putative nucleic acid binding region [nucleotide binding]; other site 167539003343 G-X-X-G motif; other site 167539003344 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 167539003345 RNA binding site [nucleotide binding]; other site 167539003346 domain interface; other site 167539003347 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 167539003348 active site 167539003349 Predicted methyltransferases [General function prediction only]; Region: COG0313 167539003350 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 167539003351 Helix-turn-helix domains; Region: HTH; cl00088 167539003352 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 167539003353 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167539003354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003355 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 167539003356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539003357 NAD binding site [chemical binding]; other site 167539003358 putative substrate binding site 2 [chemical binding]; other site 167539003359 putative substrate binding site 1 [chemical binding]; other site 167539003360 active site 167539003361 UDP-glucose 4-epimerase; Region: PLN02240 167539003362 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167539003363 NAD binding site [chemical binding]; other site 167539003364 homodimer interface [polypeptide binding]; other site 167539003365 active site 167539003366 substrate binding site [chemical binding]; other site 167539003367 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539003368 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 167539003369 putative NAD(P) binding site [chemical binding]; other site 167539003370 active site 167539003371 putative substrate binding site [chemical binding]; other site 167539003372 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 167539003373 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 167539003374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003375 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 167539003376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167539003377 active site 167539003378 motif I; other site 167539003379 motif II; other site 167539003380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003381 hydroxyglutarate oxidase; Provisional; Region: PRK11728 167539003382 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167539003383 active site 167539003384 Substrate binding site; other site 167539003385 Mg++ binding site; other site 167539003386 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 167539003387 dimer interface [polypeptide binding]; other site 167539003388 active site 167539003389 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539003390 active site 167539003391 HIGH motif; other site 167539003392 nucleotide binding site [chemical binding]; other site 167539003393 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 167539003394 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167539003395 putative ribose interaction site [chemical binding]; other site 167539003396 putative ADP binding site [chemical binding]; other site 167539003397 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539003398 extended (e) SDRs; Region: SDR_e; cd08946 167539003399 NAD(P) binding site [chemical binding]; other site 167539003400 active site 167539003401 substrate binding site [chemical binding]; other site 167539003402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003404 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167539003405 active site 167539003406 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167539003407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167539003408 active site 167539003409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539003410 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 167539003411 putative ADP-binding pocket [chemical binding]; other site 167539003412 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167539003413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167539003414 active site 167539003415 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 167539003416 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 167539003417 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167539003418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003419 Walker A/P-loop; other site 167539003420 ATP binding site [chemical binding]; other site 167539003421 Q-loop/lid; other site 167539003422 ABC transporter signature motif; other site 167539003423 Walker B; other site 167539003424 D-loop; other site 167539003425 H-loop/switch region; other site 167539003426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003427 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 167539003428 SOS regulatory protein LexA; Region: lexA; TIGR00498 167539003429 Helix-turn-helix domains; Region: HTH; cl00088 167539003430 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167539003431 Catalytic site [active] 167539003432 ornithine carbamoyltransferase; Provisional; Region: PRK00779 167539003433 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167539003434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003435 FtsH Extracellular; Region: FtsH_ext; pfam06480 167539003436 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167539003437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539003438 Walker A motif; other site 167539003439 ATP binding site [chemical binding]; other site 167539003440 Walker B motif; other site 167539003441 arginine finger; other site 167539003442 Peptidase family M41; Region: Peptidase_M41; pfam01434 167539003443 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 167539003444 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 167539003445 catalytic motif [active] 167539003446 Zn binding site [ion binding]; other site 167539003447 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 167539003448 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 167539003449 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 167539003450 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 167539003451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 167539003452 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 167539003453 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 167539003454 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 167539003455 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 167539003456 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 167539003457 dimer interface [polypeptide binding]; other site 167539003458 motif 1; other site 167539003459 active site 167539003460 motif 2; other site 167539003461 motif 3; other site 167539003462 Survival protein SurE; Region: SurE; cl00448 167539003463 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 167539003464 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 167539003465 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 167539003466 active site 167539003467 Riboflavin kinase; Region: Flavokinase; cl03312 167539003468 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 167539003469 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 167539003470 thiamine phosphate binding site [chemical binding]; other site 167539003471 active site 167539003472 pyrophosphate binding site [ion binding]; other site 167539003473 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 167539003474 thiS-thiF/thiG interaction site; other site 167539003475 AIR carboxylase; Region: AIRC; cl00310 167539003476 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 167539003477 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 167539003478 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 167539003479 homotrimer interaction site [polypeptide binding]; other site 167539003480 zinc binding site [ion binding]; other site 167539003481 CDP-binding sites; other site 167539003482 GTPase Era; Reviewed; Region: era; PRK00089 167539003483 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 167539003484 G1 box; other site 167539003485 GTP/Mg2+ binding site [chemical binding]; other site 167539003486 Switch I region; other site 167539003487 G2 box; other site 167539003488 Switch II region; other site 167539003489 G3 box; other site 167539003490 G4 box; other site 167539003491 G5 box; other site 167539003492 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 167539003493 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 167539003494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003495 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 167539003496 signal recognition particle protein; Provisional; Region: PRK10867 167539003497 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 167539003498 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167539003499 GTP binding site [chemical binding]; other site 167539003500 Signal peptide binding domain; Region: SRP_SPB; pfam02978 167539003501 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 167539003502 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 167539003503 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 167539003504 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 167539003505 tetramer interface [polypeptide binding]; other site 167539003506 TPP-binding site [chemical binding]; other site 167539003507 heterodimer interface [polypeptide binding]; other site 167539003508 phosphorylation loop region [posttranslational modification] 167539003509 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539003510 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539003511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539003512 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539003513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539003514 DNA binding residues [nucleotide binding] 167539003515 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 167539003516 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 167539003517 putative substrate binding site [chemical binding]; other site 167539003518 putative ATP binding site [chemical binding]; other site 167539003519 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 167539003520 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 167539003521 Ligand Binding Site [chemical binding]; other site 167539003522 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 167539003523 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 167539003524 putative active site [active] 167539003525 catalytic triad [active] 167539003526 putative dimer interface [polypeptide binding]; other site 167539003527 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 167539003528 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 167539003529 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167539003530 Catalytic site [active] 167539003531 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 167539003532 active site 167539003533 ribulose/triose binding site [chemical binding]; other site 167539003534 phosphate binding site [ion binding]; other site 167539003535 substrate (anthranilate) binding pocket [chemical binding]; other site 167539003536 product (indole) binding pocket [chemical binding]; other site 167539003537 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 167539003538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167539003540 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167539003541 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 167539003542 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167539003543 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 167539003544 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167539003545 hinge; other site 167539003546 active site 167539003547 acetylornithine aminotransferase; Provisional; Region: PRK02627 167539003548 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167539003549 inhibitor-cofactor binding pocket; inhibition site 167539003550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539003551 catalytic residue [active] 167539003552 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 167539003553 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167539003554 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167539003555 FAD binding domain; Region: FAD_binding_4; pfam01565 167539003556 cytosine deaminase-like protein; Validated; Region: PRK07583 167539003557 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 167539003558 active site 167539003559 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 167539003560 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167539003561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539003562 FeS/SAM binding site; other site 167539003563 TRAM domain; Region: TRAM; cl01282 167539003564 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 167539003565 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 167539003566 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539003567 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 167539003568 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 167539003569 cell division protein FtsZ; Validated; Region: PRK09330 167539003570 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 167539003571 nucleotide binding site [chemical binding]; other site 167539003572 SulA interaction site; other site 167539003573 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 167539003574 oligomerization interface [polypeptide binding]; other site 167539003575 active site 167539003576 metal binding site [ion binding]; metal-binding site 167539003577 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 167539003578 HemN C-terminal domain; Region: HemN_C; pfam06969 167539003579 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 167539003580 putative active site [active] 167539003581 Clp protease; Region: CLP_protease; pfam00574 167539003582 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539003583 oligomer interface [polypeptide binding]; other site 167539003584 active site residues [active] 167539003585 Clp protease; Region: CLP_protease; pfam00574 167539003586 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539003587 oligomer interface [polypeptide binding]; other site 167539003588 active site residues [active] 167539003589 ketol-acid reductoisomerase; Provisional; Region: PRK05479 167539003590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003591 oligomerization interface [polypeptide binding]; other site 167539003592 NAD+ binding site [chemical binding]; other site 167539003593 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 167539003594 CobD/Cbib protein; Region: CobD_Cbib; cl00561 167539003595 Bacterial sugar transferase; Region: Bac_transf; cl00939 167539003596 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 167539003597 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 167539003598 putative ADP-binding pocket [chemical binding]; other site 167539003599 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167539003600 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539003601 active site 167539003602 nucleotide binding site [chemical binding]; other site 167539003603 HIGH motif; other site 167539003604 KMSKS motif; other site 167539003605 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 167539003606 IHF dimer interface [polypeptide binding]; other site 167539003607 IHF - DNA interface [nucleotide binding]; other site 167539003608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539003609 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 167539003610 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 167539003611 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 167539003612 active site 167539003613 catalytic site [active] 167539003614 MFS/sugar transport protein; Region: MFS_2; pfam13347 167539003615 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 167539003616 Permease; Region: Permease; cl00510 167539003617 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 167539003618 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 167539003619 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 167539003620 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 167539003621 active site 167539003622 dimer interface [polypeptide binding]; other site 167539003623 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 167539003624 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 167539003625 active site 167539003626 HIGH motif; other site 167539003627 dimer interface [polypeptide binding]; other site 167539003628 KMSKS motif; other site 167539003629 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 167539003630 multifunctional aminopeptidase A; Provisional; Region: PRK00913 167539003631 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 167539003632 interface (dimer of trimers) [polypeptide binding]; other site 167539003633 Substrate-binding/catalytic site; other site 167539003634 Zn-binding sites [ion binding]; other site 167539003635 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167539003636 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167539003637 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 167539003638 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 167539003639 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 167539003640 active site 167539003641 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 167539003642 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 167539003643 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 167539003644 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 167539003645 chloroplast envelope protein translocase, IAP75 family; Region: 3a0901s03IAP75; TIGR00992 167539003646 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 167539003647 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 167539003648 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 167539003649 Surface antigen; Region: Bac_surface_Ag; cl03097 167539003650 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 167539003651 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 167539003652 ATP binding site [chemical binding]; other site 167539003653 active site 167539003654 substrate binding site [chemical binding]; other site 167539003655 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 167539003656 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 167539003657 ATP-grasp domain; Region: ATP-grasp_4; cl03087 167539003658 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167539003659 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 167539003660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 167539003661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 167539003662 dimerization interface [polypeptide binding]; other site 167539003663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 167539003664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167539003665 dimer interface [polypeptide binding]; other site 167539003666 phosphorylation site [posttranslational modification] 167539003667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539003668 ATP binding site [chemical binding]; other site 167539003669 Mg2+ binding site [ion binding]; other site 167539003670 G-X-G motif; other site 167539003671 circadian clock protein KaiC; Reviewed; Region: PRK09302 167539003672 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 167539003673 Walker A motif; other site 167539003674 ATP binding site [chemical binding]; other site 167539003675 Walker B motif; other site 167539003676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003677 Walker A motif; other site 167539003678 ATP binding site [chemical binding]; other site 167539003679 Walker B motif; other site 167539003680 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167539003681 tetramer interface [polypeptide binding]; other site 167539003682 dimer interface [polypeptide binding]; other site 167539003683 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 167539003684 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 167539003685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539003686 S-adenosylmethionine binding site [chemical binding]; other site 167539003687 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 167539003688 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 167539003689 RNA binding site [nucleotide binding]; other site 167539003690 active site 167539003691 Stage II sporulation protein; Region: SpoIID; pfam08486 167539003692 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167539003693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539003694 Cytochrome c; Region: Cytochrom_C; cl11414 167539003695 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167539003696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003697 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167539003698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167539003699 catalytic loop [active] 167539003700 iron binding site [ion binding]; other site 167539003701 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 167539003702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539003703 S-adenosylmethionine binding site [chemical binding]; other site 167539003704 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 167539003705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003706 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 167539003707 putative L-serine binding site [chemical binding]; other site 167539003708 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 167539003709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539003710 RNA binding surface [nucleotide binding]; other site 167539003711 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 167539003712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003713 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167539003714 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 167539003715 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 167539003716 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539003717 active site 167539003718 PQ loop repeat; Region: PQ-loop; cl12056 167539003719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003720 Photosystem II protein; Region: PSII; cl08223 167539003721 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 167539003722 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 167539003723 catalytic triad [active] 167539003724 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 167539003725 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167539003726 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167539003727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539003728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539003729 catalytic residue [active] 167539003730 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167539003731 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 167539003732 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 167539003733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539003734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003735 Protein of unknown function, DUF393; Region: DUF393; cl01136 167539003736 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167539003737 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 167539003738 putative active site [active] 167539003739 EamA-like transporter family; Region: EamA; cl01037 167539003740 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167539003741 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 167539003742 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167539003743 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167539003744 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 167539003745 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 167539003746 Protein of unknown function; Region: DUF3721; pfam12518 167539003747 Protein of unknown function; Region: DUF3721; pfam12518 167539003748 GLTT repeat (6 copies); Region: GLTT; pfam01744 167539003749 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 167539003750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167539003751 putative PBP binding regions; other site 167539003752 ABC-ATPase subunit interface; other site 167539003753 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167539003754 metal binding site 2 [ion binding]; metal-binding site 167539003755 putative DNA binding helix; other site 167539003756 metal binding site 1 [ion binding]; metal-binding site 167539003757 dimer interface [polypeptide binding]; other site 167539003758 structural Zn2+ binding site [ion binding]; other site 167539003759 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167539003760 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 167539003761 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167539003762 intersubunit interface [polypeptide binding]; other site 167539003763 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167539003764 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 167539003765 P-loop, Walker A motif; other site 167539003766 Base recognition motif; other site 167539003767 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167539003768 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 167539003769 structural tetrad; other site 167539003770 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167539003771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003772 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167539003773 putative high light inducible protein; Region: PHA02337 167539003774 putative high light inducible protein; Region: PHA02337 167539003775 putative high light inducible protein; Region: PHA02337 167539003776 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 167539003777 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 167539003778 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 167539003779 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 167539003780 Ion channel; Region: Ion_trans_2; cl11596 167539003781 putative high light inducible protein; Region: PHA02337 167539003782 Protein of unknown function, DUF481; Region: DUF481; cl01213 167539003783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167539003784 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167539003785 OpgC protein; Region: OpgC_C; cl00792 167539003786 short chain dehydrogenase; Provisional; Region: PRK06197 167539003787 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 167539003788 putative NAD(P) binding site [chemical binding]; other site 167539003789 active site 167539003790 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 167539003791 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 167539003792 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 167539003793 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167539003794 hinge; other site 167539003795 active site 167539003796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167539003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539003798 active site 167539003799 phosphorylation site [posttranslational modification] 167539003800 intermolecular recognition site; other site 167539003801 dimerization interface [polypeptide binding]; other site 167539003802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167539003803 DNA binding residues [nucleotide binding] 167539003804 dimerization interface [polypeptide binding]; other site 167539003805 MASE1; Region: MASE1; pfam05231 167539003806 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 167539003807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167539003808 ATP binding site [chemical binding]; other site 167539003809 Mg2+ binding site [ion binding]; other site 167539003810 G-X-G motif; other site 167539003811 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 167539003812 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 167539003813 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 167539003814 OsmC-like protein; Region: OsmC; cl00767 167539003815 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 167539003816 Cupin domain; Region: Cupin_2; cl09118 167539003817 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 167539003818 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167539003819 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167539003820 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167539003821 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 167539003822 metal binding site [ion binding]; metal-binding site 167539003823 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 167539003824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539003825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 167539003826 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167539003827 putative switch regulator; other site 167539003828 non-specific DNA interactions [nucleotide binding]; other site 167539003829 DNA binding site [nucleotide binding] 167539003830 sequence specific DNA binding site [nucleotide binding]; other site 167539003831 putative cAMP binding site [chemical binding]; other site 167539003832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167539003833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167539003834 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167539003835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003836 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 167539003837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 167539003838 dimerization interface [polypeptide binding]; other site 167539003839 putative DNA binding site [nucleotide binding]; other site 167539003840 putative Zn2+ binding site [ion binding]; other site 167539003841 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539003842 GTP cyclohydrolase I; Provisional; Region: PLN03044 167539003843 active site 167539003844 EVE domain; Region: EVE; cl00728 167539003845 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167539003846 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 167539003847 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 167539003848 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 167539003849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167539003850 active site 167539003851 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 167539003852 Sulfatase; Region: Sulfatase; cl10460 167539003853 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167539003854 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167539003855 ring oligomerisation interface [polypeptide binding]; other site 167539003856 ATP/Mg binding site [chemical binding]; other site 167539003857 stacking interactions; other site 167539003858 hinge regions; other site 167539003859 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 167539003860 oligomerisation interface [polypeptide binding]; other site 167539003861 mobile loop; other site 167539003862 roof hairpin; other site 167539003863 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 167539003864 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 167539003865 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 167539003866 alpha subunit interaction interface [polypeptide binding]; other site 167539003867 Walker A motif; other site 167539003868 ATP binding site [chemical binding]; other site 167539003869 Walker B motif; other site 167539003870 inhibitor binding site; inhibition site 167539003871 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167539003872 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 167539003873 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 167539003874 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 167539003875 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 167539003876 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167539003877 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167539003878 proline aminopeptidase P II; Provisional; Region: PRK10879 167539003879 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 167539003880 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 167539003881 active site 167539003882 Domain of unknown function DUF21; Region: DUF21; pfam01595 167539003883 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167539003884 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 167539003885 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167539003886 G1 box; other site 167539003887 GTP/Mg2+ binding site [chemical binding]; other site 167539003888 Switch I region; other site 167539003889 G2 box; other site 167539003890 Switch II region; other site 167539003891 G3 box; other site 167539003892 G4 box; other site 167539003893 G5 box; other site 167539003894 Domain of unknown function (DUF697); Region: DUF697; cl12064 167539003895 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 167539003896 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 167539003897 active site 167539003898 (T/H)XGH motif; other site 167539003899 NAD synthetase; Provisional; Region: PRK13981 167539003900 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 167539003901 multimer interface [polypeptide binding]; other site 167539003902 active site 167539003903 catalytic triad [active] 167539003904 protein interface 1 [polypeptide binding]; other site 167539003905 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 167539003906 homodimer interface [polypeptide binding]; other site 167539003907 NAD binding pocket [chemical binding]; other site 167539003908 ATP binding pocket [chemical binding]; other site 167539003909 Mg binding site [ion binding]; other site 167539003910 active-site loop [active] 167539003911 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 167539003912 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 167539003913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003914 NAD(P) binding site [chemical binding]; other site 167539003915 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 167539003916 ATP synthase; Region: ATP-synt; cl00365 167539003917 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 167539003918 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 167539003919 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 167539003920 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 167539003921 beta subunit interaction interface [polypeptide binding]; other site 167539003922 Walker A motif; other site 167539003923 ATP binding site [chemical binding]; other site 167539003924 Walker B motif; other site 167539003925 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167539003926 Plant ATP synthase F0; Region: YMF19; cl07975 167539003927 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 167539003928 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 167539003929 Plant ATP synthase F0; Region: YMF19; cl07975 167539003930 Plant ATP synthase F0; Region: YMF19; cl07975 167539003931 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 167539003932 ATP synthase subunit C; Region: ATP-synt_C; cl00466 167539003933 ATP synthase A chain; Region: ATP-synt_A; cl00413 167539003934 ATP synthase I chain; Region: ATP_synt_I; cl09170 167539003935 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 167539003936 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 167539003937 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 167539003938 ResB-like family; Region: ResB; pfam05140 167539003939 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167539003940 Nitrogen regulatory protein P-II; Region: P-II; cl00412 167539003941 Nitrogen regulatory protein P-II; Region: P-II; smart00938 167539003942 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 167539003943 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167539003944 RNA binding surface [nucleotide binding]; other site 167539003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 167539003946 adenylosuccinate lyase; Provisional; Region: PRK07380 167539003947 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 167539003948 tetramer interface [polypeptide binding]; other site 167539003949 active site 167539003950 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 167539003951 fumarate hydratase; Reviewed; Region: fumC; PRK00485 167539003952 Class II fumarases; Region: Fumarase_classII; cd01362 167539003953 active site 167539003954 tetramer interface [polypeptide binding]; other site 167539003955 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 167539003956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539003957 ATP binding site [chemical binding]; other site 167539003958 putative Mg++ binding site [ion binding]; other site 167539003959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539003960 nucleotide binding region [chemical binding]; other site 167539003961 ATP-binding site [chemical binding]; other site 167539003962 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 167539003963 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539003964 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 167539003965 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167539003966 catalytic residue [active] 167539003967 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 167539003968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539003969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003970 AAA domain; Region: AAA_26; pfam13500 167539003971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539003972 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167539003973 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 167539003974 inhibitor-cofactor binding pocket; inhibition site 167539003975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539003976 catalytic residue [active] 167539003977 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 167539003978 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167539003979 HSP70 interaction site [polypeptide binding]; other site 167539003980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 167539003981 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167539003982 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167539003983 active site 167539003984 catalytic tetrad [active] 167539003985 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 167539003986 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 167539003987 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167539003988 HEAT repeats; Region: HEAT_2; pfam13646 167539003989 HEAT repeats; Region: HEAT_2; pfam13646 167539003990 HEAT repeats; Region: HEAT_2; pfam13646 167539003991 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 167539003992 Sodium:solute symporter family; Region: SSF; cl00456 167539003993 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 167539003994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539003995 FeS/SAM binding site; other site 167539003996 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 167539003997 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167539003998 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 167539003999 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167539004000 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 167539004001 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167539004002 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 167539004003 DNA binding site [nucleotide binding] 167539004004 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 167539004005 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 167539004006 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 167539004007 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 167539004008 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167539004009 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 167539004010 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 167539004011 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167539004012 RPB1 interaction site [polypeptide binding]; other site 167539004013 RPB10 interaction site [polypeptide binding]; other site 167539004014 RPB11 interaction site [polypeptide binding]; other site 167539004015 RPB3 interaction site [polypeptide binding]; other site 167539004016 RPB12 interaction site [polypeptide binding]; other site 167539004017 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 167539004018 active site 167539004019 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 167539004020 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 167539004021 histidinol dehydrogenase; Region: hisD; TIGR00069 167539004022 NAD binding site [chemical binding]; other site 167539004023 dimerization interface [polypeptide binding]; other site 167539004024 product binding site; other site 167539004025 substrate binding site [chemical binding]; other site 167539004026 zinc binding site [ion binding]; other site 167539004027 catalytic residues [active] 167539004028 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 167539004029 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167539004030 active site 167539004031 dimer interface [polypeptide binding]; other site 167539004032 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167539004033 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 167539004034 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167539004035 protein binding site [polypeptide binding]; other site 167539004036 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 167539004037 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 167539004038 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 167539004039 Sm1 motif; other site 167539004040 D1 - D2 interaction site; other site 167539004041 D3 - B interaction site; other site 167539004042 Hfq - Hfq interaction site; other site 167539004043 RNA binding pocket [nucleotide binding]; other site 167539004044 Sm2 motif; other site 167539004045 NusA N-terminal domain; Region: NusA_N; pfam08529 167539004046 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 167539004047 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 167539004048 RNA binding site [nucleotide binding]; other site 167539004049 homodimer interface [polypeptide binding]; other site 167539004050 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 167539004051 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167539004052 G-X-X-G motif; other site 167539004053 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 167539004054 putative RNA binding cleft [nucleotide binding]; other site 167539004055 DNA polymerase subunit Cdc27; Region: CDC27; pfam09507 167539004056 translation initiation factor IF-2; Region: IF-2; TIGR00487 167539004057 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167539004058 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 167539004059 G1 box; other site 167539004060 putative GEF interaction site [polypeptide binding]; other site 167539004061 GTP/Mg2+ binding site [chemical binding]; other site 167539004062 Switch I region; other site 167539004063 G2 box; other site 167539004064 G3 box; other site 167539004065 Switch II region; other site 167539004066 G4 box; other site 167539004067 G5 box; other site 167539004068 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 167539004069 Translation-initiation factor 2; Region: IF-2; pfam11987 167539004070 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 167539004071 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 167539004072 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 167539004073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004074 FeS/SAM binding site; other site 167539004075 CAAX protease self-immunity; Region: Abi; cl00558 167539004076 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 167539004077 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 167539004078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167539004079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004080 homodimer interface [polypeptide binding]; other site 167539004081 catalytic residue [active] 167539004082 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 167539004083 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 167539004084 B12 binding site [chemical binding]; other site 167539004085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004086 FeS/SAM binding site; other site 167539004087 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 167539004088 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 167539004089 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 167539004090 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 167539004091 homodimer interface [polypeptide binding]; other site 167539004092 oligonucleotide binding site [chemical binding]; other site 167539004093 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 167539004094 RNA/DNA hybrid binding site [nucleotide binding]; other site 167539004095 active site 167539004096 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 167539004097 prephenate dehydratase; Provisional; Region: PRK11898 167539004098 Prephenate dehydratase; Region: PDT; pfam00800 167539004099 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 167539004100 putative L-Phe binding site [chemical binding]; other site 167539004101 tocopherol O-methyltransferase; Region: PLN02244 167539004102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539004103 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 167539004104 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 167539004105 elongation factor Tu; Reviewed; Region: PRK00049 167539004106 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 167539004107 G1 box; other site 167539004108 GEF interaction site [polypeptide binding]; other site 167539004109 GTP/Mg2+ binding site [chemical binding]; other site 167539004110 Switch I region; other site 167539004111 G2 box; other site 167539004112 G3 box; other site 167539004113 Switch II region; other site 167539004114 G4 box; other site 167539004115 G5 box; other site 167539004116 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 167539004117 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 167539004118 Antibiotic Binding Site [chemical binding]; other site 167539004119 elongation factor G; Reviewed; Region: PRK00007 167539004120 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 167539004121 G1 box; other site 167539004122 putative GEF interaction site [polypeptide binding]; other site 167539004123 GTP/Mg2+ binding site [chemical binding]; other site 167539004124 Switch I region; other site 167539004125 G2 box; other site 167539004126 G3 box; other site 167539004127 Switch II region; other site 167539004128 G4 box; other site 167539004129 G5 box; other site 167539004130 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 167539004131 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 167539004132 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 167539004133 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 167539004134 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 167539004135 S17 interaction site [polypeptide binding]; other site 167539004136 S8 interaction site; other site 167539004137 16S rRNA interaction site [nucleotide binding]; other site 167539004138 streptomycin interaction site [chemical binding]; other site 167539004139 23S rRNA interaction site [nucleotide binding]; other site 167539004140 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 167539004141 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 167539004142 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 167539004143 active site 167539004144 dimer interface [polypeptide binding]; other site 167539004145 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 167539004146 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 167539004147 active site 167539004148 FMN binding site [chemical binding]; other site 167539004149 substrate binding site [chemical binding]; other site 167539004150 3Fe-4S cluster binding site [ion binding]; other site 167539004151 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 167539004152 domain interface; other site 167539004153 YCII-related domain; Region: YCII; cl00999 167539004154 lipoyl synthase; Provisional; Region: PRK05481 167539004155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004156 FeS/SAM binding site; other site 167539004157 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 167539004158 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 167539004159 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 167539004160 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 167539004161 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 167539004162 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 167539004163 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 167539004164 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167539004165 NlpC/P60 family; Region: NLPC_P60; cl11438 167539004166 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167539004167 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167539004168 Ligand binding site; other site 167539004169 Putative Catalytic site; other site 167539004170 DXD motif; other site 167539004171 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 167539004172 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 167539004173 alanine racemase; Reviewed; Region: alr; PRK00053 167539004174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 167539004175 active site 167539004176 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167539004177 dimer interface [polypeptide binding]; other site 167539004178 substrate binding site [chemical binding]; other site 167539004179 catalytic residues [active] 167539004180 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167539004181 active site 167539004182 peptide chain release factor 1; Validated; Region: prfA; PRK00591 167539004183 RF-1 domain; Region: RF-1; cl02875 167539004184 RF-1 domain; Region: RF-1; cl02875 167539004185 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 167539004186 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 167539004187 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 167539004188 23S rRNA interface [nucleotide binding]; other site 167539004189 L3 interface [polypeptide binding]; other site 167539004190 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 167539004191 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 167539004192 dimerization interface 3.5A [polypeptide binding]; other site 167539004193 active site 167539004194 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 167539004195 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 167539004196 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 167539004197 alphaNTD homodimer interface [polypeptide binding]; other site 167539004198 alphaNTD - beta interaction site [polypeptide binding]; other site 167539004199 alphaNTD - beta' interaction site [polypeptide binding]; other site 167539004200 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 167539004201 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 167539004202 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 167539004203 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 167539004204 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 167539004205 adenylate kinase; Provisional; Region: PRK14531 167539004206 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 167539004207 AMP-binding site [chemical binding]; other site 167539004208 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 167539004209 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 167539004210 SecY translocase; Region: SecY; pfam00344 167539004211 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 167539004212 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 167539004213 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 167539004214 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 167539004215 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 167539004216 5S rRNA interface [nucleotide binding]; other site 167539004217 L27 interface [polypeptide binding]; other site 167539004218 23S rRNA interface [nucleotide binding]; other site 167539004219 L5 interface [polypeptide binding]; other site 167539004220 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 167539004221 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167539004222 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167539004223 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 167539004224 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 167539004225 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 167539004226 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 167539004227 KOW motif; Region: KOW; cl00354 167539004228 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 167539004229 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 167539004230 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 167539004231 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 167539004232 putative translocon interaction site; other site 167539004233 23S rRNA interface [nucleotide binding]; other site 167539004234 signal recognition particle (SRP54) interaction site; other site 167539004235 L23 interface [polypeptide binding]; other site 167539004236 trigger factor interaction site; other site 167539004237 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 167539004238 23S rRNA interface [nucleotide binding]; other site 167539004239 5S rRNA interface [nucleotide binding]; other site 167539004240 putative antibiotic binding site [chemical binding]; other site 167539004241 L25 interface [polypeptide binding]; other site 167539004242 L27 interface [polypeptide binding]; other site 167539004243 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 167539004244 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 167539004245 G-X-X-G motif; other site 167539004246 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 167539004247 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 167539004248 putative translocon binding site; other site 167539004249 protein-rRNA interface [nucleotide binding]; other site 167539004250 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 167539004251 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 167539004252 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 167539004253 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 167539004254 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 167539004255 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 167539004256 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 167539004257 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 167539004258 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 167539004259 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 167539004260 recombinase A; Provisional; Region: recA; PRK09354 167539004261 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 167539004262 hexamer interface [polypeptide binding]; other site 167539004263 Walker A motif; other site 167539004264 ATP binding site [chemical binding]; other site 167539004265 Walker B motif; other site 167539004266 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167539004267 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 167539004268 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004269 arogenate dehydrogenase; Reviewed; Region: PRK07417 167539004270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004271 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 167539004272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539004274 Domain of unknown function (DUF4308); Region: DUF4308; cl14566 167539004275 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 167539004276 MPN+ (JAMM) motif; other site 167539004277 Zinc-binding site [ion binding]; other site 167539004278 hypothetical protein; Validated; Region: PRK07411 167539004279 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 167539004280 ATP binding site [chemical binding]; other site 167539004281 substrate interface [chemical binding]; other site 167539004282 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 167539004283 active site residue [active] 167539004284 hypothetical protein; Validated; Region: PRK07413 167539004285 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167539004286 Walker A motif; other site 167539004287 homodimer interface [polypeptide binding]; other site 167539004288 ATP binding site [chemical binding]; other site 167539004289 hydroxycobalamin binding site [chemical binding]; other site 167539004290 Walker B motif; other site 167539004291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004292 Walker A motif; other site 167539004293 ATP binding site [chemical binding]; other site 167539004294 Walker B motif; other site 167539004295 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 167539004296 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 167539004297 Ligand Binding Site [chemical binding]; other site 167539004298 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 167539004299 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004300 recombination protein F; Reviewed; Region: recF; PRK00064 167539004301 Walker A/P-loop; other site 167539004302 ATP binding site [chemical binding]; other site 167539004303 Q-loop/lid; other site 167539004304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004305 ABC transporter signature motif; other site 167539004306 Walker B; other site 167539004307 D-loop; other site 167539004308 H-loop/switch region; other site 167539004309 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 167539004310 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 167539004311 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 167539004312 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 167539004313 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167539004314 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167539004315 PsaD; Region: PsaD; cl03639 167539004316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167539004317 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 167539004318 Domain of unknown function DUF59; Region: DUF59; cl00941 167539004319 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 167539004320 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 167539004321 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 167539004322 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167539004323 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 167539004324 catalytic site [active] 167539004325 putative active site [active] 167539004326 putative substrate binding site [chemical binding]; other site 167539004327 conserved hypothetical protein; Region: TIGR03492 167539004328 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 167539004329 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 167539004330 dimerization interface [polypeptide binding]; other site 167539004331 putative ATP binding site [chemical binding]; other site 167539004332 Pantoate-beta-alanine ligase; Region: PanC; cd00560 167539004333 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 167539004334 active site 167539004335 ATP-binding site [chemical binding]; other site 167539004336 pantoate-binding site; other site 167539004337 HXXH motif; other site 167539004338 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 167539004339 CMP-binding site; other site 167539004340 The sites determining sugar specificity; other site 167539004341 Low molecular weight phosphatase family; Region: LMWPc; cd00115 167539004342 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 167539004343 active site 167539004344 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 167539004345 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 167539004346 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 167539004347 heme binding pocket [chemical binding]; other site 167539004348 heme ligand [chemical binding]; other site 167539004349 isocitrate dehydrogenase; Validated; Region: PRK07362 167539004350 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167539004351 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 167539004352 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 167539004353 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 167539004354 phosphate binding site [ion binding]; other site 167539004355 D-lactate dehydrogenase; Provisional; Region: PRK11183 167539004356 FAD binding domain; Region: FAD_binding_4; pfam01565 167539004357 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 167539004358 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 167539004359 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 167539004360 active site 167539004361 catalytic residues [active] 167539004362 hydrolase; Region: PLN02578 167539004363 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 167539004364 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 167539004365 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 167539004366 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 167539004367 homodimer interface [polypeptide binding]; other site 167539004368 active site pocket [active] 167539004369 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 167539004370 dimerization interface [polypeptide binding]; other site 167539004371 active site 167539004372 metal binding site [ion binding]; metal-binding site 167539004373 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 167539004374 dsRNA binding site [nucleotide binding]; other site 167539004375 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 167539004376 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 167539004377 RimM N-terminal domain; Region: RimM; pfam01782 167539004378 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 167539004379 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 167539004380 Substrate binding site; other site 167539004381 Cupin domain; Region: Cupin_2; cl09118 167539004382 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 167539004383 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 167539004384 glutaminase active site [active] 167539004385 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 167539004386 dimer interface [polypeptide binding]; other site 167539004387 active site 167539004388 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 167539004389 dimer interface [polypeptide binding]; other site 167539004390 active site 167539004391 photosystem I subunit VII; Region: psaC; CHL00065 167539004392 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167539004393 Phosphopantetheine attachment site; Region: PP-binding; cl09936 167539004394 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 167539004395 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 167539004396 dimer interface [polypeptide binding]; other site 167539004397 active site 167539004398 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167539004399 transketolase; Region: PLN02790 167539004400 TPP-binding site [chemical binding]; other site 167539004401 dimer interface [polypeptide binding]; other site 167539004402 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167539004403 PYR/PP interface [polypeptide binding]; other site 167539004404 dimer interface [polypeptide binding]; other site 167539004405 TPP binding site [chemical binding]; other site 167539004406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167539004407 ThiC family; Region: ThiC; cl08031 167539004408 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 167539004409 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 167539004410 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 167539004411 metal binding site [ion binding]; metal-binding site 167539004412 dimer interface [polypeptide binding]; other site 167539004413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167539004414 binding surface 167539004415 TPR motif; other site 167539004416 TPR repeat; Region: TPR_11; pfam13414 167539004417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004418 binding surface 167539004419 TPR motif; other site 167539004420 TPR repeat; Region: TPR_11; pfam13414 167539004421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004422 binding surface 167539004423 TPR motif; other site 167539004424 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 167539004425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539004426 Walker A motif; other site 167539004427 ATP binding site [chemical binding]; other site 167539004428 Walker B motif; other site 167539004429 arginine finger; other site 167539004430 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 167539004431 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 167539004432 SmpB-tmRNA interface; other site 167539004433 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 167539004434 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 167539004435 dimer interface [polypeptide binding]; other site 167539004436 putative anticodon binding site; other site 167539004437 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 167539004438 motif 1; other site 167539004439 active site 167539004440 motif 2; other site 167539004441 motif 3; other site 167539004442 Ycf27; Reviewed; Region: orf27; CHL00148 167539004443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167539004444 active site 167539004445 phosphorylation site [posttranslational modification] 167539004446 intermolecular recognition site; other site 167539004447 dimerization interface [polypeptide binding]; other site 167539004448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167539004449 DNA binding site [nucleotide binding] 167539004450 rod shape-determining protein MreC; Provisional; Region: PRK14872 167539004451 rod shape-determining protein MreC; Region: MreC; pfam04085 167539004452 rod shape-determining protein MreB; Provisional; Region: PRK13927 167539004453 Cell division protein FtsA; Region: FtsA; cl11496 167539004454 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167539004455 dimer interface [polypeptide binding]; other site 167539004456 ssDNA binding site [nucleotide binding]; other site 167539004457 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167539004458 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 167539004459 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167539004460 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 167539004461 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 167539004462 oligomerization interface [polypeptide binding]; other site 167539004463 active site 167539004464 NAD+ binding site [chemical binding]; other site 167539004465 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 167539004466 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167539004467 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 167539004468 putative substrate binding site [chemical binding]; other site 167539004469 putative ATP binding site [chemical binding]; other site 167539004470 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 167539004471 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167539004472 minor groove reading motif; other site 167539004473 helix-hairpin-helix signature motif; other site 167539004474 substrate binding pocket [chemical binding]; other site 167539004475 active site 167539004476 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 167539004477 active site 167539004478 8-oxo-dGMP binding site [chemical binding]; other site 167539004479 nudix motif; other site 167539004480 metal binding site [ion binding]; metal-binding site 167539004481 hydrolase, alpha/beta fold family protein; Region: PLN02824 167539004482 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539004483 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539004484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539004485 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539004486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 167539004487 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 167539004488 MgtE intracellular N domain; Region: MgtE_N; cl15244 167539004489 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 167539004490 Divalent cation transporter; Region: MgtE; cl00786 167539004491 CrcB-like protein; Region: CRCB; cl09114 167539004492 CrcB-like protein; Region: CRCB; cl09114 167539004493 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 167539004494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 167539004495 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 167539004496 anchoring element; other site 167539004497 dimer interface [polypeptide binding]; other site 167539004498 ATP binding site [chemical binding]; other site 167539004499 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 167539004500 active site 167539004501 putative metal-binding site [ion binding]; other site 167539004502 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 167539004503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004504 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 167539004505 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 167539004506 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 167539004507 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 167539004508 Predicted transcriptional regulators [Transcription]; Region: COG1725 167539004509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 167539004510 DNA-binding site [nucleotide binding]; DNA binding site 167539004511 serine O-acetyltransferase; Region: cysE; TIGR01172 167539004512 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 167539004513 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 167539004514 trimer interface [polypeptide binding]; other site 167539004515 active site 167539004516 substrate binding site [chemical binding]; other site 167539004517 CoA binding site [chemical binding]; other site 167539004518 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 167539004519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004520 ATP binding site [chemical binding]; other site 167539004521 putative Mg++ binding site [ion binding]; other site 167539004522 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 167539004523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167539004524 Coenzyme A binding pocket [chemical binding]; other site 167539004525 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 167539004526 homopentamer interface [polypeptide binding]; other site 167539004527 active site 167539004528 YCF9; Region: Ycf9; cl09269 167539004529 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 167539004530 MutS domain I; Region: MutS_I; pfam01624 167539004531 MutS domain II; Region: MutS_II; pfam05188 167539004532 MutS family domain IV; Region: MutS_IV; pfam05190 167539004533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004534 Walker A/P-loop; other site 167539004535 ATP binding site [chemical binding]; other site 167539004536 Q-loop/lid; other site 167539004537 ABC transporter signature motif; other site 167539004538 Walker B; other site 167539004539 D-loop; other site 167539004540 H-loop/switch region; other site 167539004541 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 167539004542 DNA polymerase III subunit delta; Validated; Region: PRK07452 167539004543 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 167539004544 aspartate kinase; Provisional; Region: PRK07431 167539004545 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 167539004546 putative nucleotide binding site [chemical binding]; other site 167539004547 putative catalytic residues [active] 167539004548 putative Mg ion binding site [ion binding]; other site 167539004549 putative aspartate binding site [chemical binding]; other site 167539004550 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167539004551 putative allosteric regulatory site; other site 167539004552 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167539004553 putative allosteric regulatory residue; other site 167539004554 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167539004555 putative allosteric regulatory site; other site 167539004556 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167539004557 putative allosteric regulatory residue; other site 167539004558 excinuclease ABC subunit B; Provisional; Region: PRK05298 167539004559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167539004560 ATP binding site [chemical binding]; other site 167539004561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167539004562 nucleotide binding region [chemical binding]; other site 167539004563 ATP-binding site [chemical binding]; other site 167539004564 Ultra-violet resistance protein B; Region: UvrB; pfam12344 167539004565 UvrB/uvrC motif; Region: UVR; pfam02151 167539004566 Protein of unknown function (DUF561); Region: DUF561; pfam04481 167539004567 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 167539004568 Ligand Binding Site [chemical binding]; other site 167539004569 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 167539004570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167539004571 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 167539004572 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 167539004573 dihydrodipicolinate synthase; Region: dapA; TIGR00674 167539004574 dimer interface [polypeptide binding]; other site 167539004575 active site 167539004576 catalytic residue [active] 167539004577 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 167539004578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004579 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 167539004580 trigger factor; Provisional; Region: tig; PRK01490 167539004581 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 167539004582 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 167539004583 Clp protease; Region: CLP_protease; pfam00574 167539004584 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167539004585 oligomer interface [polypeptide binding]; other site 167539004586 active site residues [active] 167539004587 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 167539004588 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 167539004589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539004590 Walker A motif; other site 167539004591 ATP binding site [chemical binding]; other site 167539004592 Walker B motif; other site 167539004593 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167539004594 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 167539004595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167539004596 Walker A motif; other site 167539004597 ATP binding site [chemical binding]; other site 167539004598 Walker B motif; other site 167539004599 arginine finger; other site 167539004600 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 167539004601 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167539004602 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 167539004603 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 167539004604 DXD motif; other site 167539004605 Stage II sporulation protein; Region: SpoIID; pfam08486 167539004606 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167539004607 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 167539004608 ribosomal protein L20; Region: rpl20; CHL00068 167539004609 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 167539004610 23S rRNA binding site [nucleotide binding]; other site 167539004611 L21 binding site [polypeptide binding]; other site 167539004612 L13 binding site [polypeptide binding]; other site 167539004613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167539004614 binding surface 167539004615 TPR motif; other site 167539004616 TPR repeat; Region: TPR_11; pfam13414 167539004617 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 167539004618 ThiS interaction site; other site 167539004619 putative active site [active] 167539004620 tetramer interface [polypeptide binding]; other site 167539004621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167539004623 NAD(P) binding site [chemical binding]; other site 167539004624 active site 167539004625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167539004626 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 167539004627 glycine dehydrogenase; Provisional; Region: PRK05367 167539004628 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167539004629 tetramer interface [polypeptide binding]; other site 167539004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004631 catalytic residue [active] 167539004632 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167539004633 tetramer interface [polypeptide binding]; other site 167539004634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004635 catalytic residue [active] 167539004636 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 167539004637 lipoyl attachment site [posttranslational modification]; other site 167539004638 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 167539004639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167539004640 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167539004641 Di-iron ligands [ion binding]; other site 167539004642 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 167539004643 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 167539004644 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 167539004645 replicative DNA helicase; Region: DnaB; TIGR00665 167539004646 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 167539004647 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 167539004648 Walker A motif; other site 167539004649 ATP binding site [chemical binding]; other site 167539004650 Walker B motif; other site 167539004651 DNA binding loops [nucleotide binding] 167539004652 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 167539004653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167539004655 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 167539004656 UTRA domain; Region: UTRA; cl01230 167539004657 SprT-like family; Region: SprT-like; pfam10263 167539004658 SprT homologues; Region: SprT; cl01182 167539004659 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 167539004660 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 167539004661 nucleotide binding pocket [chemical binding]; other site 167539004662 K-X-D-G motif; other site 167539004663 catalytic site [active] 167539004664 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 167539004665 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 167539004666 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 167539004667 Dimer interface [polypeptide binding]; other site 167539004668 BRCT sequence motif; other site 167539004669 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167539004670 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 167539004671 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167539004672 active site 167539004673 HIGH motif; other site 167539004674 nucleotide binding site [chemical binding]; other site 167539004675 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167539004676 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 167539004677 active site 167539004678 KMSKS motif; other site 167539004679 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 167539004680 tRNA binding surface [nucleotide binding]; other site 167539004681 anticodon binding site; other site 167539004682 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 167539004683 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 167539004684 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167539004685 spermidine synthase; Provisional; Region: PRK00811 167539004686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167539004687 S-adenosylmethionine binding site [chemical binding]; other site 167539004688 Arginase family; Region: Arginase; cl00306 167539004689 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 167539004690 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167539004691 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 167539004692 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 167539004693 dimer interface [polypeptide binding]; other site 167539004694 anticodon binding site; other site 167539004695 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 167539004696 homodimer interface [polypeptide binding]; other site 167539004697 motif 1; other site 167539004698 active site 167539004699 motif 2; other site 167539004700 GAD domain; Region: GAD; pfam02938 167539004701 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 167539004702 active site 167539004703 motif 3; other site 167539004704 CTP synthetase; Validated; Region: pyrG; PRK05380 167539004705 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 167539004706 Catalytic site [active] 167539004707 active site 167539004708 UTP binding site [chemical binding]; other site 167539004709 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 167539004710 active site 167539004711 putative oxyanion hole; other site 167539004712 catalytic triad [active] 167539004713 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 167539004714 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 167539004715 Ligand Binding Site [chemical binding]; other site 167539004716 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167539004717 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167539004718 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167539004719 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 167539004720 homodimer interface [polypeptide binding]; other site 167539004721 substrate-cofactor binding pocket; other site 167539004722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004723 catalytic residue [active] 167539004724 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 167539004725 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 167539004726 hypothetical protein; Provisional; Region: PRK07394 167539004727 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167539004728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167539004729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167539004730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167539004731 polyphosphate kinase; Provisional; Region: PRK05443 167539004732 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 167539004733 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 167539004734 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 167539004735 putative domain interface [polypeptide binding]; other site 167539004736 putative active site [active] 167539004737 catalytic site [active] 167539004738 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 167539004739 putative domain interface [polypeptide binding]; other site 167539004740 putative active site [active] 167539004741 catalytic site [active] 167539004742 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167539004743 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167539004744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167539004745 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167539004746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167539004747 DNA binding residues [nucleotide binding] 167539004748 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 167539004749 NeuB family; Region: NeuB; cl00496 167539004750 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 167539004751 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 167539004752 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 167539004753 substrate binding site [chemical binding]; other site 167539004754 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 167539004755 substrate binding site [chemical binding]; other site 167539004756 ligand binding site [chemical binding]; other site 167539004757 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 167539004758 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 167539004759 Cl- selectivity filter; other site 167539004760 Cl- binding residues [ion binding]; other site 167539004761 pore gating glutamate residue; other site 167539004762 dimer interface [polypeptide binding]; other site 167539004763 H+/Cl- coupling transport residue; other site 167539004764 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 167539004765 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 167539004766 B12 binding site [chemical binding]; other site 167539004767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167539004768 FeS/SAM binding site; other site 167539004769 O-Antigen ligase; Region: Wzy_C; cl04850 167539004770 FAD dependent oxidoreductase; Region: DAO; pfam01266 167539004771 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 167539004772 StbA protein; Region: StbA; pfam06406 167539004773 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 167539004774 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 167539004775 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 167539004776 shikimate binding site; other site 167539004777 NAD(P) binding site [chemical binding]; other site 167539004778 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 167539004779 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 167539004780 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 167539004781 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 167539004782 ANP binding site [chemical binding]; other site 167539004783 Substrate Binding Site II [chemical binding]; other site 167539004784 Substrate Binding Site I [chemical binding]; other site 167539004785 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 167539004786 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 167539004787 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 167539004788 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 167539004789 Mg++ binding site [ion binding]; other site 167539004790 putative catalytic motif [active] 167539004791 putative substrate binding site [chemical binding]; other site 167539004792 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 167539004793 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 167539004794 putative ADP-binding pocket [chemical binding]; other site 167539004795 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 167539004796 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 167539004797 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 167539004798 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 167539004799 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 167539004800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167539004801 Walker A/P-loop; other site 167539004802 ATP binding site [chemical binding]; other site 167539004803 Q-loop/lid; other site 167539004804 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 167539004805 ABC transporter signature motif; other site 167539004806 Walker B; other site 167539004807 D-loop; other site 167539004808 H-loop/switch region; other site 167539004809 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167539004810 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167539004811 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167539004812 threonine synthase; Reviewed; Region: PRK06721 167539004813 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 167539004814 homodimer interface [polypeptide binding]; other site 167539004815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167539004816 catalytic residue [active]