-- dump date 20120504_155105 -- class Genbank::misc_feature -- table misc_feature_note -- id note 167555000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 167555000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 167555000003 putative DNA binding surface [nucleotide binding]; other site 167555000004 dimer interface [polypeptide binding]; other site 167555000005 beta-clamp/clamp loader binding surface; other site 167555000006 beta-clamp/translesion DNA polymerase binding surface; other site 167555000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 167555000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 167555000009 dimerization interface [polypeptide binding]; other site 167555000010 ATP binding site [chemical binding]; other site 167555000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 167555000012 dimerization interface [polypeptide binding]; other site 167555000013 ATP binding site [chemical binding]; other site 167555000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 167555000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 167555000016 active site 167555000017 tetramer interface [polypeptide binding]; other site 167555000018 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555000019 DNA gyrase, A subunit; Region: gyrA; TIGR01063 167555000020 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 167555000021 CAP-like domain; other site 167555000022 active site 167555000023 primary dimer interface [polypeptide binding]; other site 167555000024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000025 binding surface 167555000026 TPR motif; other site 167555000027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000028 binding surface 167555000029 TPR motif; other site 167555000030 iron-sulfur cluster binding protein, putative; Region: TIGR00276 167555000031 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 167555000032 Protein of unknown function (DUF502); Region: DUF502; cl01107 167555000033 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 167555000034 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 167555000035 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 167555000036 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167555000037 P loop; other site 167555000038 GTP binding site [chemical binding]; other site 167555000039 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 167555000040 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 167555000041 argininosuccinate lyase; Provisional; Region: PRK00855 167555000042 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 167555000043 active sites [active] 167555000044 tetramer interface [polypeptide binding]; other site 167555000045 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 167555000046 RNA/DNA binding site [nucleotide binding]; other site 167555000047 RRM dimerization site [polypeptide binding]; other site 167555000048 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 167555000049 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167555000050 FMN binding site [chemical binding]; other site 167555000051 active site 167555000052 catalytic residues [active] 167555000053 substrate binding site [chemical binding]; other site 167555000054 SelR domain; Region: SelR; cl00369 167555000055 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 167555000056 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 167555000057 dimer interface [polypeptide binding]; other site 167555000058 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 167555000059 chaperone protein DnaJ; Provisional; Region: PRK14293 167555000060 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555000061 HSP70 interaction site [polypeptide binding]; other site 167555000062 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 167555000063 substrate binding site [polypeptide binding]; other site 167555000064 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 167555000065 Zn binding sites [ion binding]; other site 167555000066 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167555000067 dimer interface [polypeptide binding]; other site 167555000068 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 167555000069 CPxP motif; other site 167555000070 GTPase RsgA; Reviewed; Region: PRK00098 167555000071 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 167555000072 GTPase/OB domain interface [polypeptide binding]; other site 167555000073 GTPase/Zn-binding domain interface [polypeptide binding]; other site 167555000074 GTP/Mg2+ binding site [chemical binding]; other site 167555000075 G4 box; other site 167555000076 G5 box; other site 167555000077 G1 box; other site 167555000078 Switch I region; other site 167555000079 G2 box; other site 167555000080 G3 box; other site 167555000081 Switch II region; other site 167555000082 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 167555000083 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 167555000084 FAD binding domain; Region: FAD_binding_4; pfam01565 167555000085 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 167555000086 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 167555000087 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 167555000088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555000089 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 167555000090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 167555000091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167555000092 thiamine monophosphate kinase; Provisional; Region: PRK05731 167555000093 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 167555000094 ATP binding site [chemical binding]; other site 167555000095 dimerization interface [polypeptide binding]; other site 167555000096 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 167555000097 active site 167555000098 elongation factor P; Validated; Region: PRK00529 167555000099 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 167555000100 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 167555000101 RNA binding site [nucleotide binding]; other site 167555000102 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 167555000103 RNA binding site [nucleotide binding]; other site 167555000104 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 167555000105 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 167555000106 carboxyltransferase (CT) interaction site; other site 167555000107 biotinylation site [posttranslational modification]; other site 167555000108 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 167555000109 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 167555000110 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 167555000111 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555000112 putative NAD(P) binding site [chemical binding]; other site 167555000113 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 167555000114 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 167555000115 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167555000116 homodimer interface [polypeptide binding]; other site 167555000117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000118 catalytic residue [active] 167555000119 CbiD; Region: CbiD; cl00828 167555000120 GMP synthase; Reviewed; Region: guaA; PRK00074 167555000121 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 167555000122 AMP/PPi binding site [chemical binding]; other site 167555000123 candidate oxyanion hole; other site 167555000124 catalytic triad [active] 167555000125 potential glutamine specificity residues [chemical binding]; other site 167555000126 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 167555000127 ATP Binding subdomain [chemical binding]; other site 167555000128 Ligand Binding sites [chemical binding]; other site 167555000129 Dimerization subdomain; other site 167555000130 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 167555000131 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 167555000132 cofactor binding site; other site 167555000133 DNA binding site [nucleotide binding] 167555000134 substrate interaction site [chemical binding]; other site 167555000135 LlaMI restriction endonuclease; Region: RE_LlaMI; pfam09562 167555000136 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 167555000137 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 167555000138 C-terminal domain interface [polypeptide binding]; other site 167555000139 GSH binding site (G-site) [chemical binding]; other site 167555000140 dimer interface [polypeptide binding]; other site 167555000141 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 167555000142 N-terminal domain interface [polypeptide binding]; other site 167555000143 dimer interface [polypeptide binding]; other site 167555000144 substrate binding pocket (H-site) [chemical binding]; other site 167555000145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000146 binding surface 167555000147 TPR motif; other site 167555000148 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 167555000149 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 167555000150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000151 binding surface 167555000152 TPR motif; other site 167555000153 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 167555000154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000155 binding surface 167555000156 TPR motif; other site 167555000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555000158 S-adenosylmethionine binding site [chemical binding]; other site 167555000159 Ion channel; Region: Ion_trans_2; cl11596 167555000160 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 167555000161 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167555000162 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167555000163 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167555000164 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167555000165 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167555000166 Flavin Reductases; Region: FlaRed; cl00801 167555000167 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167555000168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167555000169 Flavin Reductases; Region: FlaRed; cl00801 167555000170 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 167555000171 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 167555000172 motif 1; other site 167555000173 active site 167555000174 motif 2; other site 167555000175 motif 3; other site 167555000176 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 167555000177 arginine decarboxylase; Provisional; Region: PRK05354 167555000178 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 167555000179 dimer interface [polypeptide binding]; other site 167555000180 active site 167555000181 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555000182 catalytic residues [active] 167555000183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167555000184 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 167555000185 active site 167555000186 multimer interface [polypeptide binding]; other site 167555000187 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 167555000188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000189 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 167555000190 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 167555000191 GatB domain; Region: GatB_Yqey; cl11497 167555000192 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 167555000193 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 167555000194 CoA-binding site [chemical binding]; other site 167555000195 ATP-binding [chemical binding]; other site 167555000196 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 167555000197 heterotetramer interface [polypeptide binding]; other site 167555000198 active site pocket [active] 167555000199 cleavage site 167555000200 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000201 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000202 cyanate hydratase; Validated; Region: PRK02866 167555000203 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 167555000204 oligomer interface [polypeptide binding]; other site 167555000205 active site 167555000206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000207 binding surface 167555000208 TPR motif; other site 167555000209 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 167555000210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000211 binding surface 167555000212 TPR motif; other site 167555000213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000214 binding surface 167555000215 TPR motif; other site 167555000216 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 167555000217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000218 binding surface 167555000219 TPR motif; other site 167555000220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000221 binding surface 167555000222 TPR motif; other site 167555000223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000224 binding surface 167555000225 TPR motif; other site 167555000226 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 167555000227 Catalytic site; other site 167555000228 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000229 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000230 E4 protein; Provisional; Region: PHA03419 167555000231 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000232 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000233 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 167555000234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000235 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 167555000236 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167555000237 active site 167555000238 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 167555000239 putative high light inducible protein; Region: PHA02337 167555000240 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 167555000241 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 167555000242 NADP binding site [chemical binding]; other site 167555000243 homodimer interface [polypeptide binding]; other site 167555000244 active site 167555000245 ski2-like helicase; Provisional; Region: PRK00254 167555000246 ParA-like protein; Provisional; Region: PHA02518 167555000247 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 167555000248 P-loop; other site 167555000249 Magnesium ion binding site [ion binding]; other site 167555000250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555000251 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555000252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000253 Walker A/P-loop; other site 167555000254 ATP binding site [chemical binding]; other site 167555000255 Q-loop/lid; other site 167555000256 ABC transporter signature motif; other site 167555000257 Walker B; other site 167555000258 D-loop; other site 167555000259 H-loop/switch region; other site 167555000260 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 167555000261 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167555000262 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 167555000263 THUMP domain; Region: THUMP; cl12076 167555000264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555000265 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 167555000266 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 167555000267 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 167555000268 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 167555000269 Walker A/P-loop; other site 167555000270 ATP binding site [chemical binding]; other site 167555000271 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 167555000272 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 167555000273 ABC transporter signature motif; other site 167555000274 Walker B; other site 167555000275 D-loop; other site 167555000276 H-loop/switch region; other site 167555000277 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 167555000278 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167555000279 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 167555000280 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167555000281 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555000282 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 167555000283 YGGT family; Region: YGGT; cl00508 167555000284 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 167555000285 Protein of unknown function (DUF1509); Region: DUF1509; pfam07420 167555000286 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167555000287 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555000288 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 167555000289 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167555000290 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 167555000291 nucleotide binding site/active site [active] 167555000292 HIT family signature motif; other site 167555000293 catalytic residue [active] 167555000294 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 167555000295 active site 167555000296 catalytic residues [active] 167555000297 metal binding site [ion binding]; metal-binding site 167555000298 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 167555000299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167555000300 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 167555000301 Aminotransferase class-V; Region: Aminotran_5; pfam00266 167555000302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555000303 catalytic residue [active] 167555000304 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 167555000305 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 167555000306 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 167555000307 Walker A/P-loop; other site 167555000308 ATP binding site [chemical binding]; other site 167555000309 Q-loop/lid; other site 167555000310 ABC transporter signature motif; other site 167555000311 Walker B; other site 167555000312 D-loop; other site 167555000313 H-loop/switch region; other site 167555000314 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 167555000315 putative ABC transporter; Region: ycf24; CHL00085 167555000316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167555000317 phosphoglucomutase; Region: PLN02307 167555000318 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 167555000319 active site 167555000320 substrate binding site [chemical binding]; other site 167555000321 metal binding site [ion binding]; metal-binding site 167555000322 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 167555000323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000324 Walker A motif; other site 167555000325 ATP binding site [chemical binding]; other site 167555000326 Walker B motif; other site 167555000327 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 167555000328 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 167555000329 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 167555000330 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555000331 catalytic triad [active] 167555000332 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 167555000333 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 167555000334 Active Sites [active] 167555000335 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 167555000336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000337 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167555000338 transmembrane helices; other site 167555000339 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167555000340 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167555000341 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 167555000342 Cation transport protein; Region: TrkH; cl10514 167555000343 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 167555000344 Cation transport protein; Region: TrkH; cl10514 167555000345 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167555000346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000347 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 167555000348 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 167555000349 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167555000350 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167555000351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000352 Walker A/P-loop; other site 167555000353 ATP binding site [chemical binding]; other site 167555000354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000355 Q-loop/lid; other site 167555000356 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 167555000357 ABC transporter; Region: ABC_tran_2; pfam12848 167555000358 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 167555000359 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 167555000360 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167555000361 protein binding site [polypeptide binding]; other site 167555000362 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 167555000363 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 167555000364 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 167555000365 generic binding surface II; other site 167555000366 generic binding surface I; other site 167555000367 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 167555000368 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 167555000369 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 167555000370 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 167555000371 active site 167555000372 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 167555000373 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 167555000374 Protein of unknown function (DUF512); Region: DUF512; pfam04459 167555000375 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 167555000376 L-aspartate oxidase; Provisional; Region: PRK07395 167555000377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000378 domain; Region: Succ_DH_flav_C; pfam02910 167555000379 Vitamin K epoxide reductase family; Region: VKOR; cl01729 167555000380 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 167555000381 catalytic residues [active] 167555000382 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 167555000383 FemAB family; Region: FemAB; cl11444 167555000384 Protein of unknown function, DUF482; Region: DUF482; pfam04339 167555000385 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 167555000386 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555000387 active site 167555000388 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555000389 active site 167555000390 shikimate kinase; Reviewed; Region: aroK; PRK00131 167555000391 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 167555000392 ADP binding site [chemical binding]; other site 167555000393 magnesium binding site [ion binding]; other site 167555000394 putative shikimate binding site; other site 167555000395 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 167555000396 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167555000397 C-terminal domain interface [polypeptide binding]; other site 167555000398 GSH binding site (G-site) [chemical binding]; other site 167555000399 dimer interface [polypeptide binding]; other site 167555000400 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167555000401 N-terminal domain interface [polypeptide binding]; other site 167555000402 Protein of unknown function (DUF751); Region: DUF751; pfam05421 167555000403 Ribosome-binding factor A; Region: RBFA; cl00542 167555000404 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 167555000405 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 167555000406 active site 167555000407 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 167555000408 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 167555000409 putative hydrophobic ligand binding site [chemical binding]; other site 167555000410 Uncharacterized conserved protein [Function unknown]; Region: COG3349 167555000411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000412 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 167555000413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000414 binding surface 167555000415 TPR motif; other site 167555000416 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 167555000417 TIGR01777 family protein; Region: yfcH 167555000418 putative NAD(P) binding site [chemical binding]; other site 167555000419 putative active site [active] 167555000420 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 167555000421 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555000422 HSP70 interaction site [polypeptide binding]; other site 167555000423 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167555000424 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167555000425 dimer interface [polypeptide binding]; other site 167555000426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000427 catalytic residue [active] 167555000428 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167555000429 hypothetical protein; Provisional; Region: PRK13683 167555000430 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167555000431 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 167555000432 Walker A/P-loop; other site 167555000433 ATP binding site [chemical binding]; other site 167555000434 Q-loop/lid; other site 167555000435 ABC transporter signature motif; other site 167555000436 Walker B; other site 167555000437 D-loop; other site 167555000438 H-loop/switch region; other site 167555000439 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167555000440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555000441 active site 167555000442 phosphorylation site [posttranslational modification] 167555000443 intermolecular recognition site; other site 167555000444 dimerization interface [polypeptide binding]; other site 167555000445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555000446 DNA binding site [nucleotide binding] 167555000447 DNA polymerase III subunit delta'; Validated; Region: PRK07399 167555000448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000449 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 167555000450 TMP-binding site; other site 167555000451 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 167555000452 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 167555000453 metal-binding site [ion binding] 167555000454 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 167555000455 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 167555000456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000457 binding surface 167555000458 TPR motif; other site 167555000459 DNA repair protein RadA; Provisional; Region: PRK11823 167555000460 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000461 Walker A motif; other site 167555000462 ATP binding site [chemical binding]; other site 167555000463 Walker B motif; other site 167555000464 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 167555000465 Ycf27; Reviewed; Region: orf27; CHL00148 167555000466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555000467 active site 167555000468 phosphorylation site [posttranslational modification] 167555000469 intermolecular recognition site; other site 167555000470 dimerization interface [polypeptide binding]; other site 167555000471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555000472 DNA binding site [nucleotide binding] 167555000473 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 167555000474 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 167555000475 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 167555000476 dimer interface [polypeptide binding]; other site 167555000477 active site 167555000478 CoA binding pocket [chemical binding]; other site 167555000479 Acyl transferase domain; Region: Acyl_transf_1; cl08282 167555000480 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 167555000481 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167555000482 putative acyl-acceptor binding pocket; other site 167555000483 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 167555000484 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167555000485 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167555000486 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167555000487 active site 167555000488 NTP binding site [chemical binding]; other site 167555000489 metal binding triad [ion binding]; metal-binding site 167555000490 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 167555000491 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 167555000492 RNA/DNA binding site [nucleotide binding]; other site 167555000493 RRM dimerization site [polypeptide binding]; other site 167555000494 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 167555000495 active site lid residues [active] 167555000496 substrate binding pocket [chemical binding]; other site 167555000497 catalytic residues [active] 167555000498 substrate-Mg2+ binding site; other site 167555000499 aspartate-rich region 1; other site 167555000500 aspartate-rich region 2; other site 167555000501 Uncharacterized conserved protein [Function unknown]; Region: COG3349 167555000502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000503 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 167555000504 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 167555000505 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 167555000506 Helix-turn-helix domains; Region: HTH; cl00088 167555000507 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 167555000508 putative dimerization interface [polypeptide binding]; other site 167555000509 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 167555000510 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167555000511 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 167555000512 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167555000513 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 167555000514 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 167555000515 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167555000516 ScpA/B protein; Region: ScpA_ScpB; cl00598 167555000517 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 167555000518 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167555000519 active site 167555000520 Substrate binding site; other site 167555000521 Mg++ binding site; other site 167555000522 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 167555000523 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 167555000524 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 167555000525 FAD binding site [chemical binding]; other site 167555000526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167555000527 DNA binding residues [nucleotide binding] 167555000528 dimerization interface [polypeptide binding]; other site 167555000529 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 167555000530 putative active site [active] 167555000531 putative metal binding residues [ion binding]; other site 167555000532 signature motif; other site 167555000533 putative dimer interface [polypeptide binding]; other site 167555000534 putative phosphate binding site [ion binding]; other site 167555000535 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 167555000536 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 167555000537 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 167555000538 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 167555000539 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 167555000540 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 167555000541 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167555000542 NADH dehydrogenase; Region: NADHdh; cl00469 167555000543 citrate synthase; Provisional; Region: PRK14036 167555000544 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 167555000545 oxalacetate binding site [chemical binding]; other site 167555000546 citrylCoA binding site [chemical binding]; other site 167555000547 coenzyme A binding site [chemical binding]; other site 167555000548 catalytic triad [active] 167555000549 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 167555000550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 167555000551 active site residue [active] 167555000552 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 167555000553 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 167555000554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000555 catalytic residue [active] 167555000556 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 167555000557 Predicted RNA interaction site [nucleotide binding]; other site 167555000558 putative binding site; other site 167555000559 Mutations affecting start-site selection; other site 167555000560 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 167555000561 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 167555000562 ligand-binding site [chemical binding]; other site 167555000563 AIR carboxylase; Region: AIRC; cl00310 167555000564 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 167555000565 active site 167555000566 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 167555000567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555000568 S-adenosylmethionine binding site [chemical binding]; other site 167555000569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555000570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167555000571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555000572 active site 167555000573 phosphorylation site [posttranslational modification] 167555000574 intermolecular recognition site; other site 167555000575 dimerization interface [polypeptide binding]; other site 167555000576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167555000577 DNA binding residues [nucleotide binding] 167555000578 dimerization interface [polypeptide binding]; other site 167555000579 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 167555000580 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555000581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555000582 catalytic residue [active] 167555000583 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 167555000584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555000585 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 167555000586 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 167555000587 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167555000588 active site 167555000589 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 167555000590 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 167555000591 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 167555000592 active site 167555000593 UbiA prenyltransferase family; Region: UbiA; cl00337 167555000594 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 167555000595 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167555000596 glutathione synthetase; Provisional; Region: PRK05246 167555000597 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 167555000598 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555000599 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 167555000600 GSH binding site [chemical binding]; other site 167555000601 catalytic residues [active] 167555000602 RF-1 domain; Region: RF-1; cl02875 167555000603 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 167555000604 RF-1 domain; Region: RF-1; cl02875 167555000605 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 167555000606 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 167555000607 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 167555000608 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 167555000609 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 167555000610 glutamine binding [chemical binding]; other site 167555000611 catalytic triad [active] 167555000612 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 167555000613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555000614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000615 homodimer interface [polypeptide binding]; other site 167555000616 catalytic residue [active] 167555000617 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 167555000618 arginine-tRNA ligase; Region: PLN02286 167555000619 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 167555000620 active site 167555000621 HIGH motif; other site 167555000622 KMSK motif region; other site 167555000623 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 167555000624 tRNA binding surface [nucleotide binding]; other site 167555000625 anticodon binding site; other site 167555000626 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 167555000627 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 167555000628 dimerization interface [polypeptide binding]; other site 167555000629 active site 167555000630 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 167555000631 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 167555000632 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 167555000633 G1 box; other site 167555000634 GTP/Mg2+ binding site [chemical binding]; other site 167555000635 Switch I region; other site 167555000636 G2 box; other site 167555000637 Switch II region; other site 167555000638 G3 box; other site 167555000639 G4 box; other site 167555000640 G5 box; other site 167555000641 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 167555000642 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 167555000643 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 167555000644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 167555000645 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 167555000646 synthetase active site [active] 167555000647 NTP binding site [chemical binding]; other site 167555000648 metal binding site [ion binding]; metal-binding site 167555000649 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 167555000650 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 167555000651 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 167555000652 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 167555000653 Walker A/P-loop; other site 167555000654 ATP binding site [chemical binding]; other site 167555000655 Q-loop/lid; other site 167555000656 ABC transporter signature motif; other site 167555000657 Walker B; other site 167555000658 D-loop; other site 167555000659 H-loop/switch region; other site 167555000660 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 167555000661 Walker A/P-loop; other site 167555000662 ATP binding site [chemical binding]; other site 167555000663 Q-loop/lid; other site 167555000664 ABC transporter signature motif; other site 167555000665 Walker B; other site 167555000666 D-loop; other site 167555000667 H-loop/switch region; other site 167555000668 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 167555000669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555000670 RNA binding surface [nucleotide binding]; other site 167555000671 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 167555000672 active site 167555000673 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 167555000674 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 167555000675 GTP/Mg2+ binding site [chemical binding]; other site 167555000676 G4 box; other site 167555000677 G5 box; other site 167555000678 G1 box; other site 167555000679 Switch I region; other site 167555000680 G2 box; other site 167555000681 G3 box; other site 167555000682 Switch II region; other site 167555000683 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 167555000684 Phosphoglycerate kinase; Region: PGK; pfam00162 167555000685 substrate binding site [chemical binding]; other site 167555000686 hinge regions; other site 167555000687 ADP binding site [chemical binding]; other site 167555000688 catalytic site [active] 167555000689 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 167555000690 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 167555000691 active site 167555000692 homodimer interface [polypeptide binding]; other site 167555000693 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 167555000694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555000695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000696 homodimer interface [polypeptide binding]; other site 167555000697 catalytic residue [active] 167555000698 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 167555000699 quinone interaction residues [chemical binding]; other site 167555000700 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 167555000701 active site 167555000702 catalytic residues [active] 167555000703 FMN binding site [chemical binding]; other site 167555000704 substrate binding site [chemical binding]; other site 167555000705 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 167555000706 RNA/DNA hybrid binding site [nucleotide binding]; other site 167555000707 active site 167555000708 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 167555000709 L11 interface [polypeptide binding]; other site 167555000710 putative EF-Tu interaction site [polypeptide binding]; other site 167555000711 putative EF-G interaction site [polypeptide binding]; other site 167555000712 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 167555000713 23S rRNA interface [nucleotide binding]; other site 167555000714 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 167555000715 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 167555000716 mRNA/rRNA interface [nucleotide binding]; other site 167555000717 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 167555000718 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 167555000719 23S rRNA interface [nucleotide binding]; other site 167555000720 L7/L12 interface [polypeptide binding]; other site 167555000721 putative thiostrepton binding site; other site 167555000722 L25 interface [polypeptide binding]; other site 167555000723 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 167555000724 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 167555000725 putative homodimer interface [polypeptide binding]; other site 167555000726 KOW motif; Region: KOW; cl00354 167555000727 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 167555000728 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 167555000729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000730 Walker A motif; other site 167555000731 ATP binding site [chemical binding]; other site 167555000732 Walker B motif; other site 167555000733 arginine finger; other site 167555000734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000735 Walker A motif; other site 167555000736 ATP binding site [chemical binding]; other site 167555000737 Walker B motif; other site 167555000738 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167555000739 enolase; Provisional; Region: eno; PRK00077 167555000740 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 167555000741 dimer interface [polypeptide binding]; other site 167555000742 metal binding site [ion binding]; metal-binding site 167555000743 substrate binding pocket [chemical binding]; other site 167555000744 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167555000745 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 167555000746 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 167555000747 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167555000748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000750 Nitrogen regulatory protein P-II; Region: P-II; cl00412 167555000751 Domain of unknown function (DUF897); Region: DUF897; cl01312 167555000752 high affinity sulphate transporter 1; Region: sulP; TIGR00815 167555000753 Permease family; Region: Xan_ur_permease; cl00967 167555000754 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167555000755 chaperone protein DnaJ; Provisional; Region: PRK14299 167555000756 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555000757 HSP70 interaction site [polypeptide binding]; other site 167555000758 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167555000759 substrate binding site [polypeptide binding]; other site 167555000760 dimer interface [polypeptide binding]; other site 167555000761 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 167555000762 dimer interface [polypeptide binding]; other site 167555000763 active site 167555000764 aspartate-rich active site metal binding site; other site 167555000765 allosteric magnesium binding site [ion binding]; other site 167555000766 Schiff base residues; other site 167555000767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167555000768 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 167555000769 active site 167555000770 metal binding site [ion binding]; metal-binding site 167555000771 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167555000772 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 167555000773 Walker A/P-loop; other site 167555000774 ATP binding site [chemical binding]; other site 167555000775 Q-loop/lid; other site 167555000776 ABC transporter signature motif; other site 167555000777 Walker B; other site 167555000778 D-loop; other site 167555000779 H-loop/switch region; other site 167555000780 Smr domain; Region: Smr; cl02619 167555000781 GTPase CgtA; Reviewed; Region: obgE; PRK12299 167555000782 GTP1/OBG; Region: GTP1_OBG; pfam01018 167555000783 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 167555000784 G1 box; other site 167555000785 GTP/Mg2+ binding site [chemical binding]; other site 167555000786 Switch I region; other site 167555000787 G2 box; other site 167555000788 G3 box; other site 167555000789 Switch II region; other site 167555000790 G4 box; other site 167555000791 G5 box; other site 167555000792 CP12 domain; Region: CP12; cl14670 167555000793 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 167555000794 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 167555000795 putative dimer interface [polypeptide binding]; other site 167555000796 N-terminal domain interface [polypeptide binding]; other site 167555000797 putative substrate binding pocket (H-site) [chemical binding]; other site 167555000798 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 167555000799 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 167555000800 active site 167555000801 Zn binding site [ion binding]; other site 167555000802 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167555000803 protein I interface; other site 167555000804 D2 interface; other site 167555000805 protein T interface; other site 167555000806 chlorophyll binding site; other site 167555000807 beta carotene binding site; other site 167555000808 pheophytin binding site; other site 167555000809 manganese-stabilizing polypeptide interface; other site 167555000810 CP43 interface; other site 167555000811 protein L interface; other site 167555000812 oxygen evolving complex binding site; other site 167555000813 bromide binding site; other site 167555000814 quinone binding site; other site 167555000815 Fe binding site [ion binding]; other site 167555000816 core light harvesting interface; other site 167555000817 cytochrome b559 alpha subunit interface; other site 167555000818 cytochrome c-550 interface; other site 167555000819 protein J interface; other site 167555000820 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 167555000821 Tetramer interface [polypeptide binding]; other site 167555000822 active site 167555000823 FMN-binding site [chemical binding]; other site 167555000824 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 167555000825 active site 167555000826 intersubunit interface [polypeptide binding]; other site 167555000827 catalytic residue [active] 167555000828 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167555000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000830 Walker A motif; other site 167555000831 ATP binding site [chemical binding]; other site 167555000832 Walker B motif; other site 167555000833 arginine finger; other site 167555000834 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555000835 ATP-sulfurylase; Region: ATPS; cd00517 167555000836 active site 167555000837 HXXH motif; other site 167555000838 flexible loop; other site 167555000839 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 167555000840 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 167555000841 Flavoprotein; Region: Flavoprotein; cl08021 167555000842 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 167555000843 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 167555000844 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167555000845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000846 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 167555000847 active site 167555000848 DNA binding site [nucleotide binding] 167555000849 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 167555000850 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 167555000851 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 167555000852 putative di-iron ligands [ion binding]; other site 167555000853 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 167555000854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555000855 active site 167555000856 HIGH motif; other site 167555000857 nucleotide binding site [chemical binding]; other site 167555000858 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 167555000859 active site 167555000860 KMSKS motif; other site 167555000861 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 167555000862 tRNA binding surface [nucleotide binding]; other site 167555000863 anticodon binding site; other site 167555000864 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167555000865 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 167555000866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555000867 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555000868 Thymidylate synthase complementing protein; Region: Thy1; cl03630 167555000869 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 167555000870 trimer interface [polypeptide binding]; other site 167555000871 active site 167555000872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000873 Walker A motif; other site 167555000874 ATP binding site [chemical binding]; other site 167555000875 Walker B motif; other site 167555000876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 167555000877 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 167555000878 ligand binding site [chemical binding]; other site 167555000879 flexible hinge region; other site 167555000880 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167555000881 putative switch regulator; other site 167555000882 non-specific DNA interactions [nucleotide binding]; other site 167555000883 DNA binding site [nucleotide binding] 167555000884 sequence specific DNA binding site [nucleotide binding]; other site 167555000885 putative cAMP binding site [chemical binding]; other site 167555000886 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 167555000887 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 167555000888 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 167555000889 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 167555000890 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 167555000891 putative active site [active] 167555000892 catalytic residue [active] 167555000893 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 167555000894 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 167555000895 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 167555000896 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 167555000897 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 167555000898 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 167555000899 substrate binding site [chemical binding]; other site 167555000900 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 167555000901 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 167555000902 substrate binding site [chemical binding]; other site 167555000903 ligand binding site [chemical binding]; other site 167555000904 competence damage-inducible protein A; Provisional; Region: PRK00549 167555000905 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 167555000906 putative MPT binding site; other site 167555000907 Competence-damaged protein; Region: CinA; cl00666 167555000908 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 167555000909 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 167555000910 dimer interface [polypeptide binding]; other site 167555000911 glycine-pyridoxal phosphate binding site [chemical binding]; other site 167555000912 active site 167555000913 folate binding site [chemical binding]; other site 167555000914 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 167555000915 integral membrane protein MviN; Region: mviN; TIGR01695 167555000916 MatE; Region: MatE; cl10513 167555000917 Sugar fermentation stimulation protein; Region: SfsA; cl00647 167555000918 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 167555000919 LytB protein; Region: LYTB; cl00507 167555000920 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 167555000921 DoxX; Region: DoxX; cl00976 167555000922 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 167555000923 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 167555000924 purine monophosphate binding site [chemical binding]; other site 167555000925 dimer interface [polypeptide binding]; other site 167555000926 putative catalytic residues [active] 167555000927 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 167555000928 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 167555000929 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 167555000930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167555000931 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 167555000932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 167555000933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555000934 ATP binding site [chemical binding]; other site 167555000935 Mg2+ binding site [ion binding]; other site 167555000936 G-X-G motif; other site 167555000937 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 167555000938 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 167555000939 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 167555000940 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167555000941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555000942 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 167555000943 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 167555000944 Domain of unknown function DUF21; Region: DUF21; pfam01595 167555000945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167555000946 Transporter associated domain; Region: CorC_HlyC; cl08393 167555000947 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555000948 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 167555000949 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 167555000950 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167555000951 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 167555000952 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 167555000953 active site 167555000954 substrate binding site [chemical binding]; other site 167555000955 metal binding site [ion binding]; metal-binding site 167555000956 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167555000957 active site 167555000958 dimerization interface [polypeptide binding]; other site 167555000959 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 167555000960 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 167555000961 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 167555000962 putative active site pocket [active] 167555000963 4-fold oligomerization interface [polypeptide binding]; other site 167555000964 metal binding residues [ion binding]; metal-binding site 167555000965 3-fold/trimer interface [polypeptide binding]; other site 167555000966 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 167555000967 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 167555000968 NAD binding site [chemical binding]; other site 167555000969 homotetramer interface [polypeptide binding]; other site 167555000970 homodimer interface [polypeptide binding]; other site 167555000971 substrate binding site [chemical binding]; other site 167555000972 active site 167555000973 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 167555000974 putative catalytic residue [active] 167555000975 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167555000976 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167555000977 inhibitor-cofactor binding pocket; inhibition site 167555000978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000979 catalytic residue [active] 167555000980 DNA photolyase; Region: DNA_photolyase; pfam00875 167555000981 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 167555000982 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 167555000983 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 167555000984 dimer interface [polypeptide binding]; other site 167555000985 ADP-ribose binding site [chemical binding]; other site 167555000986 active site 167555000987 nudix motif; other site 167555000988 metal binding site [ion binding]; metal-binding site 167555000989 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 167555000990 catalytic center binding site [active] 167555000991 ATP binding site [chemical binding]; other site 167555000992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555000993 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 167555000994 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 167555000995 metal ion-dependent adhesion site (MIDAS); other site 167555000996 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 167555000997 mce related protein; Region: MCE; cl15431 167555000998 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 167555000999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001000 Walker A/P-loop; other site 167555001001 ATP binding site [chemical binding]; other site 167555001002 Q-loop/lid; other site 167555001003 ABC transporter signature motif; other site 167555001004 Walker B; other site 167555001005 D-loop; other site 167555001006 H-loop/switch region; other site 167555001007 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 167555001008 phosphate binding site [ion binding]; other site 167555001009 putative substrate binding pocket [chemical binding]; other site 167555001010 dimer interface [polypeptide binding]; other site 167555001011 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 167555001012 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 167555001013 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 167555001014 Rubredoxin [Energy production and conversion]; Region: COG1773 167555001015 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 167555001016 iron binding site [ion binding]; other site 167555001017 Ycf48-like protein; Provisional; Region: PRK13684 167555001018 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 167555001019 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 167555001020 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 167555001021 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 167555001022 PsbL protein; Region: PsbL; cl03581 167555001023 PsbJ; Region: PsbJ; cl09469 167555001024 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167555001025 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 167555001026 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 167555001027 dimerization interface [polypeptide binding]; other site 167555001028 putative ATP binding site [chemical binding]; other site 167555001029 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167555001030 active site 167555001031 NTP binding site [chemical binding]; other site 167555001032 metal binding triad [ion binding]; metal-binding site 167555001033 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 167555001034 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 167555001035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001037 Phycobilisome protein; Region: Phycobilisome; cl08227 167555001038 Phycobilisome protein; Region: Phycobilisome; cl08227 167555001039 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 167555001040 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 167555001041 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 167555001042 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 167555001043 CpeS-like protein; Region: CpeS; pfam09367 167555001044 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 167555001045 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167555001046 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555001047 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 167555001048 NAD binding site [chemical binding]; other site 167555001049 putative substrate binding site 2 [chemical binding]; other site 167555001050 putative substrate binding site 1 [chemical binding]; other site 167555001051 active site 167555001052 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 167555001053 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555001054 putative NAD(P) binding site [chemical binding]; other site 167555001055 active site 167555001056 putative substrate binding site [chemical binding]; other site 167555001057 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 167555001058 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 167555001059 N- and C-terminal domain interface [polypeptide binding]; other site 167555001060 D-xylulose kinase; Region: XylB; TIGR01312 167555001061 active site 167555001062 MgATP binding site [chemical binding]; other site 167555001063 catalytic site [active] 167555001064 metal binding site [ion binding]; metal-binding site 167555001065 carbohydrate binding site [chemical binding]; other site 167555001066 S-adenosylmethionine synthetase; Validated; Region: PRK05250 167555001067 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 167555001068 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 167555001069 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 167555001070 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 167555001071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555001072 active site 167555001073 motif I; other site 167555001074 motif II; other site 167555001075 30S ribosomal protein S1; Reviewed; Region: PRK07400 167555001076 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167555001077 RNA binding site [nucleotide binding]; other site 167555001078 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167555001079 RNA binding site [nucleotide binding]; other site 167555001080 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 167555001081 RNA binding site [nucleotide binding]; other site 167555001082 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 167555001083 ATP cone domain; Region: ATP-cone; pfam03477 167555001084 Photosystem II reaction centre T protein; Region: PsbT; cl11601 167555001085 Photosystem II protein; Region: PSII; cl08223 167555001086 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 167555001087 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167555001088 active site 167555001089 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 167555001090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001091 S-adenosylmethionine binding site [chemical binding]; other site 167555001092 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 167555001093 Septum formation topological specificity factor MinE; Region: MinE; cl00538 167555001094 septum site-determining protein MinD; Region: minD_bact; TIGR01968 167555001095 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 167555001096 P-loop; other site 167555001097 ADP binding residues [chemical binding]; other site 167555001098 Switch I; other site 167555001099 Switch II; other site 167555001100 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 167555001101 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 167555001102 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167555001103 Zn2+ binding site [ion binding]; other site 167555001104 Mg2+ binding site [ion binding]; other site 167555001105 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167555001106 C-terminal peptidase (prc); Region: prc; TIGR00225 167555001107 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167555001108 protein binding site [polypeptide binding]; other site 167555001109 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167555001110 Catalytic dyad [active] 167555001111 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 167555001112 Qi binding site; other site 167555001113 intrachain domain interface; other site 167555001114 interchain domain interface [polypeptide binding]; other site 167555001115 heme bH binding site [chemical binding]; other site 167555001116 heme bL binding site [chemical binding]; other site 167555001117 Qo binding site; other site 167555001118 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 167555001119 interchain domain interface [polypeptide binding]; other site 167555001120 intrachain domain interface; other site 167555001121 Qi binding site; other site 167555001122 Qo binding site; other site 167555001123 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 167555001124 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 167555001125 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 167555001126 DNA binding site [nucleotide binding] 167555001127 catalytic residue [active] 167555001128 H2TH interface [polypeptide binding]; other site 167555001129 putative catalytic residues [active] 167555001130 turnover-facilitating residue; other site 167555001131 intercalation triad [nucleotide binding]; other site 167555001132 8OG recognition residue [nucleotide binding]; other site 167555001133 putative reading head residues; other site 167555001134 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167555001135 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167555001136 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 167555001137 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 167555001138 putative peptidoglycan binding site; other site 167555001139 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 167555001140 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 167555001141 putative peptidoglycan binding site; other site 167555001142 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 167555001143 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 167555001144 NAD(P) binding site [chemical binding]; other site 167555001145 catalytic residues [active] 167555001146 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167555001147 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167555001148 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555001149 putative high light inducible protein; Region: PHA02337 167555001150 putative high light inducible protein; Region: PHA02337 167555001151 putative high light inducible protein; Region: PHA02337 167555001152 putative high light inducible protein; Region: PHA02337 167555001153 putative high light inducible protein; Region: PHA02337 167555001154 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 167555001155 trimer interface [polypeptide binding]; other site 167555001156 active site 167555001157 dimer interface [polypeptide binding]; other site 167555001158 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 167555001159 active site 167555001160 dinuclear metal binding site [ion binding]; other site 167555001161 dimerization interface [polypeptide binding]; other site 167555001162 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 167555001163 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 167555001164 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167555001165 FMN binding site [chemical binding]; other site 167555001166 active site 167555001167 catalytic residues [active] 167555001168 substrate binding site [chemical binding]; other site 167555001169 GTP-binding protein Der; Reviewed; Region: PRK00093 167555001170 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 167555001171 G1 box; other site 167555001172 GTP/Mg2+ binding site [chemical binding]; other site 167555001173 Switch I region; other site 167555001174 G2 box; other site 167555001175 Switch II region; other site 167555001176 G3 box; other site 167555001177 G4 box; other site 167555001178 G5 box; other site 167555001179 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 167555001180 G1 box; other site 167555001181 GTP/Mg2+ binding site [chemical binding]; other site 167555001182 Switch I region; other site 167555001183 G2 box; other site 167555001184 G3 box; other site 167555001185 Switch II region; other site 167555001186 G4 box; other site 167555001187 G5 box; other site 167555001188 Cobalt transport protein; Region: CbiQ; cl00463 167555001189 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 167555001190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167555001191 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555001192 catalytic residue [active] 167555001193 Protein of unknown function (DUF552); Region: DUF552; cl00775 167555001194 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 167555001195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001196 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167555001197 Recombination protein O N terminal; Region: RecO_N; pfam11967 167555001198 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 167555001199 Recombination protein O C terminal; Region: RecO_C; pfam02565 167555001200 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 167555001201 catalytic residue [active] 167555001202 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 167555001203 30S subunit binding site; other site 167555001204 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 167555001205 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 167555001206 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 167555001207 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 167555001208 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 167555001209 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 167555001210 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 167555001211 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 167555001212 E3 interaction surface; other site 167555001213 lipoyl attachment site [posttranslational modification]; other site 167555001214 e3 binding domain; Region: E3_binding; pfam02817 167555001215 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 167555001216 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 167555001217 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 167555001218 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167555001219 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167555001220 dimer interface [polypeptide binding]; other site 167555001221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001222 catalytic residue [active] 167555001223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555001224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555001225 catalytic residue [active] 167555001226 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 167555001227 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167555001228 homodimer interface [polypeptide binding]; other site 167555001229 substrate-cofactor binding pocket; other site 167555001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001231 catalytic residue [active] 167555001232 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 167555001233 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 167555001234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555001235 RNA binding surface [nucleotide binding]; other site 167555001236 Domain of unknown function DUF37; Region: DUF37; cl00506 167555001237 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555001238 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 167555001239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167555001240 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 167555001241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555001242 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167555001243 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555001244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555001245 catalytic residue [active] 167555001246 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 167555001247 High-affinity nickel-transport protein; Region: NicO; cl00964 167555001248 NifU-like domain; Region: NifU; cl00484 167555001249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001250 Predicted dehydrogenase [General function prediction only]; Region: COG0579 167555001251 GTP-binding protein LepA; Provisional; Region: PRK05433 167555001252 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 167555001253 G1 box; other site 167555001254 putative GEF interaction site [polypeptide binding]; other site 167555001255 GTP/Mg2+ binding site [chemical binding]; other site 167555001256 Switch I region; other site 167555001257 G2 box; other site 167555001258 G3 box; other site 167555001259 Switch II region; other site 167555001260 G4 box; other site 167555001261 G5 box; other site 167555001262 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 167555001263 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 167555001264 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 167555001265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555001266 dimer interface [polypeptide binding]; other site 167555001267 conserved gate region; other site 167555001268 ABC-ATPase subunit interface; other site 167555001269 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 167555001270 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167555001271 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 167555001272 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 167555001273 16S rRNA methyltransferase B; Provisional; Region: PRK14901 167555001274 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 167555001275 putative RNA binding site [nucleotide binding]; other site 167555001276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001277 S-adenosylmethionine binding site [chemical binding]; other site 167555001278 UbiA prenyltransferase family; Region: UbiA; cl00337 167555001279 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167555001280 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167555001281 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167555001282 substrate binding site [chemical binding]; other site 167555001283 glutamase interaction surface [polypeptide binding]; other site 167555001284 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 167555001285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001286 S-adenosylmethionine binding site [chemical binding]; other site 167555001287 Protein of unknown function (DUF721); Region: DUF721; cl02324 167555001288 phage shock protein A; Region: phageshock_pspA; TIGR02977 167555001289 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 167555001290 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167555001291 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 167555001292 Walker A/P-loop; other site 167555001293 ATP binding site [chemical binding]; other site 167555001294 Q-loop/lid; other site 167555001295 ABC transporter signature motif; other site 167555001296 Walker B; other site 167555001297 D-loop; other site 167555001298 H-loop/switch region; other site 167555001299 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 167555001300 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 167555001301 active site 167555001302 interdomain interaction site; other site 167555001303 putative metal-binding site [ion binding]; other site 167555001304 nucleotide binding site [chemical binding]; other site 167555001305 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 167555001306 domain I; other site 167555001307 phosphate binding site [ion binding]; other site 167555001308 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 167555001309 domain II; other site 167555001310 domain III; other site 167555001311 nucleotide binding site [chemical binding]; other site 167555001312 DNA binding groove [nucleotide binding] 167555001313 catalytic site [active] 167555001314 domain IV; other site 167555001315 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 167555001316 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 167555001317 putative dimer interface [polypeptide binding]; other site 167555001318 active site pocket [active] 167555001319 putative cataytic base [active] 167555001320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167555001321 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 167555001322 Lumazine binding domain; Region: Lum_binding; pfam00677 167555001323 Lumazine binding domain; Region: Lum_binding; pfam00677 167555001324 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167555001325 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167555001326 Subunit I/III interface [polypeptide binding]; other site 167555001327 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 167555001328 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 167555001329 D-pathway; other site 167555001330 Low-spin heme binding site [chemical binding]; other site 167555001331 Putative water exit pathway; other site 167555001332 Binuclear center (active site) [active] 167555001333 K-pathway; other site 167555001334 Putative proton exit pathway; other site 167555001335 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 167555001336 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 167555001337 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 167555001338 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 167555001339 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 167555001340 UbiA prenyltransferase family; Region: UbiA; cl00337 167555001341 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001342 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 167555001343 Walker A/P-loop; other site 167555001344 ATP binding site [chemical binding]; other site 167555001345 Q-loop/lid; other site 167555001346 ABC transporter signature motif; other site 167555001347 Walker B; other site 167555001348 D-loop; other site 167555001349 H-loop/switch region; other site 167555001350 ABC-2 type transporter; Region: ABC2_membrane; cl11417 167555001351 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167555001352 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167555001353 ring oligomerisation interface [polypeptide binding]; other site 167555001354 ATP/Mg binding site [chemical binding]; other site 167555001355 stacking interactions; other site 167555001356 hinge regions; other site 167555001357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 167555001358 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 167555001359 NAD(P) binding site [chemical binding]; other site 167555001360 homotetramer interface [polypeptide binding]; other site 167555001361 homodimer interface [polypeptide binding]; other site 167555001362 active site 167555001363 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 167555001364 substrate binding site; other site 167555001365 dimer interface; other site 167555001366 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 167555001367 dimer interface [polypeptide binding]; other site 167555001368 catalytic triad [active] 167555001369 UbiA prenyltransferase family; Region: UbiA; cl00337 167555001370 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 167555001371 Helix-turn-helix domains; Region: HTH; cl00088 167555001372 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 167555001373 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 167555001374 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 167555001375 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 167555001376 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 167555001377 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 167555001378 cytochrome b subunit interaction site [polypeptide binding]; other site 167555001379 [2Fe-2S] cluster binding site [ion binding]; other site 167555001380 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 167555001381 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 167555001382 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 167555001383 Domain of unknown function (DUF814); Region: DUF814; pfam05670 167555001384 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 167555001385 catalytic site [active] 167555001386 G-X2-G-X-G-K; other site 167555001387 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 167555001388 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 167555001389 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 167555001390 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 167555001391 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 167555001392 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 167555001393 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 167555001394 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167555001395 HIGH motif; other site 167555001396 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167555001397 active site 167555001398 KMSKS motif; other site 167555001399 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 167555001400 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 167555001401 active site 167555001402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001403 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 167555001404 DRTGG domain; Region: DRTGG; cl12147 167555001405 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 167555001406 Protein of unknown function (DUF520); Region: DUF520; cl00723 167555001407 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 167555001408 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 167555001409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167555001410 inhibitor-cofactor binding pocket; inhibition site 167555001411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001412 catalytic residue [active] 167555001413 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 167555001414 putative phosphate binding site [ion binding]; other site 167555001415 putative catalytic site [active] 167555001416 active site 167555001417 metal binding site A [ion binding]; metal-binding site 167555001418 DNA binding site [nucleotide binding] 167555001419 putative AP binding site [nucleotide binding]; other site 167555001420 putative metal binding site B [ion binding]; other site 167555001421 Protein of unknown function DUF111; Region: DUF111; cl03398 167555001422 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 167555001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555001424 dimer interface [polypeptide binding]; other site 167555001425 conserved gate region; other site 167555001426 putative PBP binding loops; other site 167555001427 ABC-ATPase subunit interface; other site 167555001428 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 167555001429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 167555001430 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167555001431 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001432 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167555001433 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 167555001434 aromatic arch; other site 167555001435 DCoH dimer interaction site [polypeptide binding]; other site 167555001436 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167555001437 DCoH tetramer interaction site [polypeptide binding]; other site 167555001438 substrate binding site [chemical binding]; other site 167555001439 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 167555001440 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 167555001441 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 167555001442 active site 167555001443 Zn binding site [ion binding]; other site 167555001444 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167555001445 dimer interface [polypeptide binding]; other site 167555001446 substrate binding site [chemical binding]; other site 167555001447 metal binding sites [ion binding]; metal-binding site 167555001448 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 167555001449 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 167555001450 domain interfaces; other site 167555001451 active site 167555001452 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555001453 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555001454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555001455 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555001456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555001457 DNA binding residues [nucleotide binding] 167555001458 primosome assembly protein PriA; Validated; Region: PRK05580 167555001459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555001460 ATP binding site [chemical binding]; other site 167555001461 putative Mg++ binding site [ion binding]; other site 167555001462 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555001463 nucleotide binding region [chemical binding]; other site 167555001464 ATP-binding site [chemical binding]; other site 167555001465 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 167555001466 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 167555001467 feedback inhibition sensing region; other site 167555001468 homohexameric interface [polypeptide binding]; other site 167555001469 nucleotide binding site [chemical binding]; other site 167555001470 N-acetyl-L-glutamate binding site [chemical binding]; other site 167555001471 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 167555001472 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167555001473 dimer interface [polypeptide binding]; other site 167555001474 ssDNA binding site [nucleotide binding]; other site 167555001475 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167555001476 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 167555001477 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 167555001478 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 167555001479 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167555001480 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 167555001481 substrate binding site [chemical binding]; other site 167555001482 ATP binding site [chemical binding]; other site 167555001483 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 167555001484 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 167555001485 GDP-binding site [chemical binding]; other site 167555001486 ACT binding site; other site 167555001487 IMP binding site; other site 167555001488 photosystem II protein Psb27; Provisional; Region: PLN00064; cl11841 167555001489 prolyl-tRNA synthetase; Provisional; Region: PRK09194 167555001490 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 167555001491 dimer interface [polypeptide binding]; other site 167555001492 motif 1; other site 167555001493 active site 167555001494 motif 2; other site 167555001495 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 167555001496 putative deacylase active site [active] 167555001497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 167555001498 active site 167555001499 motif 3; other site 167555001500 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 167555001501 anticodon binding site; other site 167555001502 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167555001503 dimer interface [polypeptide binding]; other site 167555001504 substrate binding site [chemical binding]; other site 167555001505 metal binding sites [ion binding]; metal-binding site 167555001506 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 167555001507 ArsC family; Region: ArsC; pfam03960 167555001508 putative ArsC-like catalytic residues; other site 167555001509 putative TRX-like catalytic residues [active] 167555001510 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167555001511 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555001512 Catalytic site [active] 167555001513 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555001514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167555001515 catalytic core [active] 167555001516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167555001517 catalytic core [active] 167555001518 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 167555001519 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 167555001520 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167555001521 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167555001522 transaldolase-like protein; Provisional; Region: PTZ00411 167555001523 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 167555001524 active site 167555001525 dimer interface [polypeptide binding]; other site 167555001526 catalytic residue [active] 167555001527 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 167555001528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001529 ribosome recycling factor; Reviewed; Region: frr; PRK00083 167555001530 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 167555001531 hinge region; other site 167555001532 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 167555001533 putative nucleotide binding site [chemical binding]; other site 167555001534 uridine monophosphate binding site [chemical binding]; other site 167555001535 homohexameric interface [polypeptide binding]; other site 167555001536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001537 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 167555001538 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167555001539 homodimer interface [polypeptide binding]; other site 167555001540 Walker A motif; other site 167555001541 ATP binding site [chemical binding]; other site 167555001542 hydroxycobalamin binding site [chemical binding]; other site 167555001543 Walker B motif; other site 167555001544 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 167555001545 Phage integrase family; Region: Phage_integrase; pfam00589 167555001546 DNA binding site [nucleotide binding] 167555001547 Int/Topo IB signature motif; other site 167555001548 active site 167555001549 catalytic residues [active] 167555001550 ferrochelatase; Reviewed; Region: hemH; PRK00035 167555001551 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 167555001552 C-terminal domain interface [polypeptide binding]; other site 167555001553 active site 167555001554 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 167555001555 active site 167555001556 N-terminal domain interface [polypeptide binding]; other site 167555001557 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 167555001558 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 167555001559 PYR/PP interface [polypeptide binding]; other site 167555001560 dimer interface [polypeptide binding]; other site 167555001561 TPP binding site [chemical binding]; other site 167555001562 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 167555001563 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 167555001564 TPP-binding site [chemical binding]; other site 167555001565 dimer interface [polypeptide binding]; other site 167555001566 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 167555001567 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167555001568 RNA binding site [nucleotide binding]; other site 167555001569 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167555001570 RNA binding site [nucleotide binding]; other site 167555001571 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167555001572 RNA binding site [nucleotide binding]; other site 167555001573 Creatinine amidohydrolase; Region: Creatininase; cl00618 167555001574 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 167555001575 dinuclear metal binding motif [ion binding]; other site 167555001576 acyl-ACP reductase; Provisional; Region: PRK14982 167555001577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001578 NAD(P) binding pocket [chemical binding]; other site 167555001579 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 167555001580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 167555001581 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 167555001582 classical (c) SDRs; Region: SDR_c; cd05233 167555001583 NAD(P) binding site [chemical binding]; other site 167555001584 active site 167555001585 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 167555001586 active site 167555001587 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 167555001588 active site 167555001589 putative substrate binding region [chemical binding]; other site 167555001590 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167555001591 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 167555001592 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 167555001593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001594 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 167555001595 NAD(P) binding site [chemical binding]; other site 167555001596 active site 167555001597 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 167555001598 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 167555001599 P-loop; other site 167555001600 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 167555001601 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 167555001602 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 167555001603 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 167555001604 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 167555001605 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 167555001606 putative hexamer interface [polypeptide binding]; other site 167555001607 putative hexagonal pore; other site 167555001608 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 167555001609 putative hexamer interface [polypeptide binding]; other site 167555001610 putative hexagonal pore; other site 167555001611 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167555001612 active site 167555001613 dimerization interface [polypeptide binding]; other site 167555001614 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167555001615 Hexamer interface [polypeptide binding]; other site 167555001616 Hexagonal pore residue; other site 167555001617 Hexagonal pore; other site 167555001618 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 167555001619 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 167555001620 dimer interface [polypeptide binding]; other site 167555001621 catalytic residue [active] 167555001622 metal binding site [ion binding]; metal-binding site 167555001623 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 167555001624 multimerization interface [polypeptide binding]; other site 167555001625 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167555001626 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167555001627 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 167555001628 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167555001629 Hexamer/Pentamer interface [polypeptide binding]; other site 167555001630 central pore; other site 167555001631 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167555001632 Hexamer/Pentamer interface [polypeptide binding]; other site 167555001633 central pore; other site 167555001634 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167555001635 Hexamer interface [polypeptide binding]; other site 167555001636 Hexagonal pore residue; other site 167555001637 Hexagonal pore; other site 167555001638 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 167555001639 aromatic arch; other site 167555001640 DCoH dimer interaction site [polypeptide binding]; other site 167555001641 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167555001642 DCoH tetramer interaction site [polypeptide binding]; other site 167555001643 substrate binding site [chemical binding]; other site 167555001644 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 167555001645 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 167555001646 homotrimer interaction site [polypeptide binding]; other site 167555001647 putative active site [active] 167555001648 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 167555001649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167555001650 ATP phosphoribosyltransferase; Region: HisG; cl15266 167555001651 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555001652 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555001653 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 167555001654 Walker A/P-loop; other site 167555001655 ATP binding site [chemical binding]; other site 167555001656 Q-loop/lid; other site 167555001657 ABC transporter signature motif; other site 167555001658 Walker B; other site 167555001659 D-loop; other site 167555001660 H-loop/switch region; other site 167555001661 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 167555001662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167555001663 Coenzyme A binding pocket [chemical binding]; other site 167555001664 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 167555001665 Probable Catalytic site; other site 167555001666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167555001667 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 167555001668 hypothetical protein; Validated; Region: PRK06672 167555001669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555001670 Walker A motif; other site 167555001671 ATP binding site [chemical binding]; other site 167555001672 Walker B motif; other site 167555001673 arginine finger; other site 167555001674 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 167555001675 DnaA box-binding interface [nucleotide binding]; other site 167555001676 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167555001677 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167555001678 C-terminal domain interface [polypeptide binding]; other site 167555001679 GSH binding site (G-site) [chemical binding]; other site 167555001680 dimer interface [polypeptide binding]; other site 167555001681 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167555001682 N-terminal domain interface [polypeptide binding]; other site 167555001683 dimer interface [polypeptide binding]; other site 167555001684 substrate binding pocket (H-site) [chemical binding]; other site 167555001685 glutathione reductase; Validated; Region: PRK06116 167555001686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001687 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167555001688 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 167555001689 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167555001690 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167555001691 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 167555001692 active site 167555001693 substrate binding pocket [chemical binding]; other site 167555001694 dimer interface [polypeptide binding]; other site 167555001695 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 167555001696 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167555001697 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 167555001698 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 167555001699 substrate binding site [chemical binding]; other site 167555001700 active site 167555001701 catalytic residues [active] 167555001702 heterodimer interface [polypeptide binding]; other site 167555001703 YCII-related domain; Region: YCII; cl00999 167555001704 Cytochrome c; Region: Cytochrom_C; cl11414 167555001705 D-xylulose kinase; Region: XylB; TIGR01312 167555001706 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 167555001707 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555001708 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555001709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555001710 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555001711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555001712 DNA binding residues [nucleotide binding] 167555001713 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 167555001714 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 167555001715 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167555001716 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555001717 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167555001718 Clp amino terminal domain; Region: Clp_N; pfam02861 167555001719 Clp amino terminal domain; Region: Clp_N; pfam02861 167555001720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555001721 Walker A motif; other site 167555001722 ATP binding site [chemical binding]; other site 167555001723 Walker B motif; other site 167555001724 arginine finger; other site 167555001725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555001726 Walker A motif; other site 167555001727 ATP binding site [chemical binding]; other site 167555001728 Walker B motif; other site 167555001729 arginine finger; other site 167555001730 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167555001731 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 167555001732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001733 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167555001734 NAD(P) binding site [chemical binding]; other site 167555001735 active site 167555001736 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 167555001737 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 167555001738 substrate binding site [chemical binding]; other site 167555001739 active site 167555001740 glycogen branching enzyme; Provisional; Region: PRK05402 167555001741 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 167555001742 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 167555001743 active site 167555001744 catalytic site [active] 167555001745 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 167555001746 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 167555001747 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 167555001748 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 167555001749 Protein of function (DUF2518); Region: DUF2518; pfam10726 167555001750 TIGR02099 family protein; Region: TIGR02099 167555001751 Family of unknown function (DUF490); Region: DUF490; pfam04357 167555001752 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 167555001753 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 167555001754 putative catalytic cysteine [active] 167555001755 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555001756 active site 167555001757 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 167555001758 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 167555001759 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 167555001760 active site 167555001761 Zn binding site [ion binding]; other site 167555001762 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 167555001763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 167555001764 homoserine kinase; Provisional; Region: PRK01212 167555001765 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 167555001766 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 167555001767 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 167555001768 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 167555001769 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 167555001770 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 167555001771 active site 167555001772 dimer interface [polypeptide binding]; other site 167555001773 motif 1; other site 167555001774 motif 2; other site 167555001775 motif 3; other site 167555001776 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 167555001777 anticodon binding site; other site 167555001778 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 167555001779 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 167555001780 active site 167555001781 HIGH motif; other site 167555001782 dimer interface [polypeptide binding]; other site 167555001783 KMSKS motif; other site 167555001784 Domain of unknown function (DUF697); Region: DUF697; cl12064 167555001785 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 167555001786 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 167555001787 metal binding site [ion binding]; metal-binding site 167555001788 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167555001789 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 167555001790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167555001791 ABC-ATPase subunit interface; other site 167555001792 dimer interface [polypeptide binding]; other site 167555001793 putative PBP binding regions; other site 167555001794 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 167555001795 Protein of unknown function (DUF760); Region: DUF760; pfam05542 167555001796 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555001797 Catalytic site [active] 167555001798 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 167555001799 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 167555001800 dimer interface [polypeptide binding]; other site 167555001801 tetramer interface [polypeptide binding]; other site 167555001802 PYR/PP interface [polypeptide binding]; other site 167555001803 TPP binding site [chemical binding]; other site 167555001804 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 167555001805 TPP-binding site; other site 167555001806 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 167555001807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 167555001808 substrate binding site [chemical binding]; other site 167555001809 oxyanion hole (OAH) forming residues; other site 167555001810 trimer interface [polypeptide binding]; other site 167555001811 glycogen synthase; Provisional; Region: glgA; PRK00654 167555001812 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 167555001813 ADP-binding pocket [chemical binding]; other site 167555001814 homodimer interface [polypeptide binding]; other site 167555001815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167555001816 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 167555001817 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 167555001818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555001819 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 167555001820 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 167555001821 hinge; other site 167555001822 active site 167555001823 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 167555001824 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 167555001825 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 167555001826 Predicted amidohydrolase [General function prediction only]; Region: COG0388 167555001827 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 167555001828 putative active site [active] 167555001829 catalytic triad [active] 167555001830 dimer interface [polypeptide binding]; other site 167555001831 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 167555001832 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 167555001833 active site 167555001834 metal binding site [ion binding]; metal-binding site 167555001835 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 167555001836 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167555001837 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167555001838 substrate binding pocket [chemical binding]; other site 167555001839 chain length determination region; other site 167555001840 substrate-Mg2+ binding site; other site 167555001841 catalytic residues [active] 167555001842 aspartate-rich region 1; other site 167555001843 active site lid residues [active] 167555001844 aspartate-rich region 2; other site 167555001845 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 167555001846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555001847 active site 167555001848 motif I; other site 167555001849 motif II; other site 167555001850 acetyl-CoA synthetase; Provisional; Region: PRK00174 167555001851 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 167555001852 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 167555001853 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 167555001854 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 167555001855 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 167555001856 active site 167555001857 substrate binding site [chemical binding]; other site 167555001858 catalytic site [active] 167555001859 histidyl-tRNA synthetase; Region: hisS; TIGR00442 167555001860 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 167555001861 dimer interface [polypeptide binding]; other site 167555001862 motif 1; other site 167555001863 active site 167555001864 motif 2; other site 167555001865 motif 3; other site 167555001866 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 167555001867 anticodon binding site; other site 167555001868 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 167555001869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001870 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167555001871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001872 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 167555001873 Photosystem II protein; Region: PSII; cl08223 167555001874 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 167555001875 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555001876 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 167555001877 putative N-terminal domain interface [polypeptide binding]; other site 167555001878 putative dimer interface [polypeptide binding]; other site 167555001879 putative substrate binding pocket (H-site) [chemical binding]; other site 167555001880 T5orf172 domain; Region: T5orf172; cl11176 167555001881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001882 NAD(P) binding site [chemical binding]; other site 167555001883 active site 167555001884 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167555001885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001887 NAD(P) binding site [chemical binding]; other site 167555001888 active site 167555001889 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 167555001890 Mechanosensitive ion channel; Region: MS_channel; pfam00924 167555001891 Isochorismatase family; Region: Isochorismatase; pfam00857 167555001892 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 167555001893 catalytic triad [active] 167555001894 dimer interface [polypeptide binding]; other site 167555001895 conserved cis-peptide bond; other site 167555001896 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167555001897 metal binding site 2 [ion binding]; metal-binding site 167555001898 putative DNA binding helix; other site 167555001899 metal binding site 1 [ion binding]; metal-binding site 167555001900 structural Zn2+ binding site [ion binding]; other site 167555001901 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 167555001902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555001903 FeS/SAM binding site; other site 167555001904 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 167555001905 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 167555001906 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 167555001907 Phosphotransferase enzyme family; Region: APH; pfam01636 167555001908 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 167555001909 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167555001910 homodimer interface [polypeptide binding]; other site 167555001911 substrate-cofactor binding pocket; other site 167555001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001913 catalytic residue [active] 167555001914 Homoserine O-succinyltransferase; Region: HTS; pfam04204 167555001915 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 167555001916 proposed active site lysine [active] 167555001917 conserved cys residue [active] 167555001918 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167555001919 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 167555001920 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167555001921 putative active site [active] 167555001922 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 167555001923 putative active site [active] 167555001924 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555001925 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167555001926 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167555001927 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555001928 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555001929 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 167555001930 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167555001931 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 167555001932 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 167555001933 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 167555001934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001935 S-adenosylmethionine binding site [chemical binding]; other site 167555001936 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 167555001937 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 167555001938 G1 box; other site 167555001939 putative GEF interaction site [polypeptide binding]; other site 167555001940 GTP/Mg2+ binding site [chemical binding]; other site 167555001941 Switch I region; other site 167555001942 G2 box; other site 167555001943 G3 box; other site 167555001944 Switch II region; other site 167555001945 G4 box; other site 167555001946 G5 box; other site 167555001947 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 167555001948 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 167555001949 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 167555001950 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 167555001951 dimerization interface [polypeptide binding]; other site 167555001952 domain crossover interface; other site 167555001953 redox-dependent activation switch; other site 167555001954 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167555001955 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 167555001956 Walker A/P-loop; other site 167555001957 ATP binding site [chemical binding]; other site 167555001958 Q-loop/lid; other site 167555001959 ABC transporter signature motif; other site 167555001960 Walker B; other site 167555001961 D-loop; other site 167555001962 H-loop/switch region; other site 167555001963 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 167555001964 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 167555001965 Integral membrane protein DUF92; Region: DUF92; cl00793 167555001966 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 167555001967 active site 167555001968 catalytic triad [active] 167555001969 oxyanion hole [active] 167555001970 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167555001971 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167555001972 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 167555001973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555001974 Walker A/P-loop; other site 167555001975 ATP binding site [chemical binding]; other site 167555001976 Q-loop/lid; other site 167555001977 ABC transporter signature motif; other site 167555001978 Walker B; other site 167555001979 D-loop; other site 167555001980 H-loop/switch region; other site 167555001981 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 167555001982 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 167555001983 aspartate aminotransferase; Provisional; Region: PRK05764 167555001984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555001985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001986 homodimer interface [polypeptide binding]; other site 167555001987 catalytic residue [active] 167555001988 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 167555001989 Fe-S cluster binding site [ion binding]; other site 167555001990 active site 167555001991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 167555001992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 167555001993 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167555001994 C-terminal peptidase (prc); Region: prc; TIGR00225 167555001995 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167555001996 protein binding site [polypeptide binding]; other site 167555001997 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167555001998 Catalytic dyad [active] 167555001999 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167555002000 Quinolinate synthetase A protein; Region: NadA; cl00420 167555002001 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 167555002002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167555002003 active site 167555002004 metal binding site [ion binding]; metal-binding site 167555002005 Repair protein; Region: Repair_PSII; cl01535 167555002006 Uncharacterized conserved protein [Function unknown]; Region: COG1565 167555002007 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 167555002008 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 167555002009 active site 167555002010 dimer interface [polypeptide binding]; other site 167555002011 metal binding site [ion binding]; metal-binding site 167555002012 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 167555002013 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555002014 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 167555002015 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167555002016 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 167555002017 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 167555002018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002019 flavoprotein, HI0933 family; Region: TIGR00275 167555002020 DoxX; Region: DoxX; cl00976 167555002021 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 167555002022 Domain of unknown function DUF20; Region: UPF0118; cl00465 167555002023 Psb28 protein; Region: Psb28; cl04326 167555002024 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 167555002025 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 167555002026 active site residue [active] 167555002027 GUN4-like; Region: GUN4; pfam05419 167555002028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 167555002029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555002030 S-adenosylmethionine binding site [chemical binding]; other site 167555002031 glutamine synthetase, type I; Region: GlnA; TIGR00653 167555002032 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 167555002033 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 167555002034 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 167555002035 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167555002036 homodimer interface [polypeptide binding]; other site 167555002037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555002038 catalytic residue [active] 167555002039 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 167555002040 nucleoside/Zn binding site; other site 167555002041 dimer interface [polypeptide binding]; other site 167555002042 catalytic motif [active] 167555002043 Protein of unknown function (DUF429); Region: DUF429; cl12046 167555002044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555002045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555002046 catalytic residue [active] 167555002047 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 167555002048 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 167555002049 G1 box; other site 167555002050 GTP/Mg2+ binding site [chemical binding]; other site 167555002051 Switch I region; other site 167555002052 G2 box; other site 167555002053 Switch II region; other site 167555002054 G3 box; other site 167555002055 G4 box; other site 167555002056 G5 box; other site 167555002057 Domain of unknown function (DUF697); Region: DUF697; cl12064 167555002058 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 167555002059 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 167555002060 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 167555002061 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167555002062 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167555002063 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167555002064 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167555002065 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167555002066 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167555002067 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 167555002068 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 167555002069 DevC protein; Region: devC; TIGR01185 167555002070 FtsX-like permease family; Region: FtsX; pfam02687 167555002071 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 167555002072 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 167555002073 Walker A/P-loop; other site 167555002074 ATP binding site [chemical binding]; other site 167555002075 Q-loop/lid; other site 167555002076 ABC transporter signature motif; other site 167555002077 Walker B; other site 167555002078 D-loop; other site 167555002079 H-loop/switch region; other site 167555002080 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167555002081 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 167555002082 Probable Catalytic site; other site 167555002083 metal-binding site 167555002084 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 167555002085 rRNA interaction site [nucleotide binding]; other site 167555002086 S8 interaction site; other site 167555002087 putative laminin-1 binding site; other site 167555002088 elongation factor Ts; Reviewed; Region: tsf; PRK12332 167555002089 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 167555002090 Elongation factor TS; Region: EF_TS; pfam00889 167555002091 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 167555002092 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 167555002093 generic binding surface II; other site 167555002094 ssDNA binding site; other site 167555002095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555002096 ATP binding site [chemical binding]; other site 167555002097 putative Mg++ binding site [ion binding]; other site 167555002098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555002099 nucleotide binding region [chemical binding]; other site 167555002100 ATP-binding site [chemical binding]; other site 167555002101 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 167555002102 sulfite reductase subunit beta; Provisional; Region: PRK13504 167555002103 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555002104 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555002105 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 167555002106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002107 geranylgeranyl reductase; Region: ChlP; TIGR02028 167555002108 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 167555002109 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 167555002110 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 167555002111 G1 box; other site 167555002112 putative GEF interaction site [polypeptide binding]; other site 167555002113 GTP/Mg2+ binding site [chemical binding]; other site 167555002114 Switch I region; other site 167555002115 G2 box; other site 167555002116 G3 box; other site 167555002117 Switch II region; other site 167555002118 G4 box; other site 167555002119 G5 box; other site 167555002120 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 167555002121 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 167555002122 Domain of unknown function (DUF309); Region: DUF309; cl00667 167555002123 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 167555002124 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 167555002125 Walker A/P-loop; other site 167555002126 ATP binding site [chemical binding]; other site 167555002127 Q-loop/lid; other site 167555002128 ABC transporter signature motif; other site 167555002129 Walker B; other site 167555002130 D-loop; other site 167555002131 H-loop/switch region; other site 167555002132 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 167555002133 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 167555002134 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 167555002135 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 167555002136 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 167555002137 substrate binding site [chemical binding]; other site 167555002138 hexamer interface [polypeptide binding]; other site 167555002139 metal binding site [ion binding]; metal-binding site 167555002140 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 167555002141 putative active site [active] 167555002142 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 167555002143 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 167555002144 tRNA; other site 167555002145 putative tRNA binding site [nucleotide binding]; other site 167555002146 putative NADP binding site [chemical binding]; other site 167555002147 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 167555002148 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 167555002149 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 167555002150 ligand binding site; other site 167555002151 oligomer interface; other site 167555002152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167555002153 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 167555002154 dimer interface [polypeptide binding]; other site 167555002155 N-terminal domain interface [polypeptide binding]; other site 167555002156 sulfate 1 binding site; other site 167555002157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002158 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167555002159 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 167555002160 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 167555002161 putative active site [active] 167555002162 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 167555002163 Dehydratase family; Region: ILVD_EDD; cl00340 167555002164 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555002165 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555002166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555002167 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 167555002168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002169 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167555002170 chaperone protein DnaJ; Provisional; Region: PRK14291 167555002171 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 167555002172 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 167555002173 putative active site [active] 167555002174 catalytic triad [active] 167555002175 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 167555002176 active site 167555002177 intersubunit interface [polypeptide binding]; other site 167555002178 catalytic residue [active] 167555002179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167555002180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002181 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 167555002182 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 167555002183 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 167555002184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 167555002185 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 167555002186 active site 167555002187 tartrate dehydrogenase; Provisional; Region: PRK08194 167555002188 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167555002189 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 167555002190 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 167555002191 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 167555002192 trimer interface [polypeptide binding]; other site 167555002193 active site 167555002194 UDP-GlcNAc binding site [chemical binding]; other site 167555002195 lipid binding site [chemical binding]; lipid-binding site 167555002196 gamma-glutamyl kinase; Provisional; Region: PRK05429 167555002197 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 167555002198 nucleotide binding site [chemical binding]; other site 167555002199 homotetrameric interface [polypeptide binding]; other site 167555002200 putative phosphate binding site [ion binding]; other site 167555002201 putative allosteric binding site; other site 167555002202 PUA domain; Region: PUA; cl00607 167555002203 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 167555002204 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 167555002205 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 167555002206 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 167555002207 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 167555002208 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167555002209 catalytic residues [active] 167555002210 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555002211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002212 NAD(P) binding site [chemical binding]; other site 167555002213 active site 167555002214 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 167555002215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167555002216 Coenzyme A binding pocket [chemical binding]; other site 167555002217 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167555002218 NAD(P) binding site [chemical binding]; other site 167555002219 putative active site [active] 167555002220 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 167555002221 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167555002222 minor groove reading motif; other site 167555002223 helix-hairpin-helix signature motif; other site 167555002224 substrate binding pocket [chemical binding]; other site 167555002225 active site 167555002226 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 167555002227 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 167555002228 Walker A/P-loop; other site 167555002229 ATP binding site [chemical binding]; other site 167555002230 Q-loop/lid; other site 167555002231 ABC transporter signature motif; other site 167555002232 Walker B; other site 167555002233 D-loop; other site 167555002234 H-loop/switch region; other site 167555002235 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 167555002236 Ferritin-like domain; Region: Ferritin; pfam00210 167555002237 ferroxidase diiron center [ion binding]; other site 167555002238 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167555002239 Helix-turn-helix domains; Region: HTH; cl00088 167555002240 putative switch regulator; other site 167555002241 non-specific DNA interactions [nucleotide binding]; other site 167555002242 DNA binding site [nucleotide binding] 167555002243 sequence specific DNA binding site [nucleotide binding]; other site 167555002244 putative cAMP binding site [chemical binding]; other site 167555002245 Photosystem II protein; Region: PSII; cl08223 167555002246 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 167555002247 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167555002248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002249 Walker A/P-loop; other site 167555002250 ATP binding site [chemical binding]; other site 167555002251 Q-loop/lid; other site 167555002252 ABC transporter signature motif; other site 167555002253 Walker B; other site 167555002254 D-loop; other site 167555002255 H-loop/switch region; other site 167555002256 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 167555002257 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 167555002258 [2Fe-2S] cluster binding site [ion binding]; other site 167555002259 UDP-glucose 4-epimerase; Region: PLN02240 167555002260 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167555002261 NAD binding site [chemical binding]; other site 167555002262 homodimer interface [polypeptide binding]; other site 167555002263 active site 167555002264 substrate binding site [chemical binding]; other site 167555002265 Cupin domain; Region: Cupin_2; cl09118 167555002266 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 167555002267 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 167555002268 NADP binding site [chemical binding]; other site 167555002269 active site 167555002270 putative substrate binding site [chemical binding]; other site 167555002271 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 167555002272 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 167555002273 NAD binding site [chemical binding]; other site 167555002274 substrate binding site [chemical binding]; other site 167555002275 homodimer interface [polypeptide binding]; other site 167555002276 active site 167555002277 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 167555002278 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 167555002279 active site 167555002280 homodimer interface [polypeptide binding]; other site 167555002281 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 167555002282 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 167555002283 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 167555002284 NAD(P) binding site [chemical binding]; other site 167555002285 homodimer interface [polypeptide binding]; other site 167555002286 substrate binding site [chemical binding]; other site 167555002287 active site 167555002288 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 167555002289 Mg++ binding site [ion binding]; other site 167555002290 putative catalytic motif [active] 167555002291 putative substrate binding site [chemical binding]; other site 167555002292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555002293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002294 NAD(P) binding site [chemical binding]; other site 167555002295 active site 167555002296 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 167555002297 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 167555002298 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 167555002299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002300 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 167555002301 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167555002302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002303 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 167555002304 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 167555002305 active site 167555002306 dimer interface [polypeptide binding]; other site 167555002307 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 167555002308 Ligand Binding Site [chemical binding]; other site 167555002309 Molecular Tunnel; other site 167555002310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167555002311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555002312 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 167555002313 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 167555002314 Ligand Binding Site [chemical binding]; other site 167555002315 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 167555002316 NeuB family; Region: NeuB; cl00496 167555002317 SAF domain; Region: SAF; cl00555 167555002318 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 167555002319 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 167555002320 active site 167555002321 homodimer interface [polypeptide binding]; other site 167555002322 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 167555002323 ligand binding site; other site 167555002324 tetramer interface; other site 167555002325 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167555002326 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167555002327 substrate binding site [chemical binding]; other site 167555002328 glutamase interaction surface [polypeptide binding]; other site 167555002329 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167555002330 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167555002331 putative active site [active] 167555002332 oxyanion strand; other site 167555002333 catalytic triad [active] 167555002334 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 167555002335 Chain length determinant protein; Region: Wzz; cl01623 167555002336 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 167555002337 polysaccharide export protein Wza; Provisional; Region: PRK15078 167555002338 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 167555002339 HicB family; Region: HicB; pfam05534 167555002340 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555002341 L-asparaginase II; Region: Asparaginase_II; cl01842 167555002342 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 167555002343 Domain of unknown function DUF143; Region: DUF143; cl00519 167555002344 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 167555002345 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 167555002346 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167555002347 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555002348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167555002349 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555002350 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 167555002351 IMP binding site; other site 167555002352 dimer interface [polypeptide binding]; other site 167555002353 interdomain contacts; other site 167555002354 partial ornithine binding site; other site 167555002355 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 167555002356 dinuclear metal binding motif [ion binding]; other site 167555002357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555002358 catalytic loop [active] 167555002359 iron binding site [ion binding]; other site 167555002360 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 167555002361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002362 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 167555002363 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002364 Walker A/P-loop; other site 167555002365 ATP binding site [chemical binding]; other site 167555002366 Q-loop/lid; other site 167555002367 ABC transporter signature motif; other site 167555002368 Walker B; other site 167555002369 D-loop; other site 167555002370 H-loop/switch region; other site 167555002371 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 167555002372 Protein of unknown function (DUF990); Region: DUF990; cl01496 167555002373 Protein of unknown function (DUF990); Region: DUF990; cl01496 167555002374 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 167555002375 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555002376 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167555002377 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 167555002378 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 167555002379 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 167555002380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167555002381 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 167555002382 active site 167555002383 homodimer interface [polypeptide binding]; other site 167555002384 catalytic site [active] 167555002385 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 167555002386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555002387 active site 167555002388 motif I; other site 167555002389 motif II; other site 167555002390 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167555002391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002392 active site 167555002393 RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027 167555002394 T5orf172 domain; Region: T5orf172; cl11176 167555002395 Bacitracin resistance protein BacA; Region: BacA; cl00858 167555002396 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167555002397 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555002398 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555002399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002400 Walker A/P-loop; other site 167555002401 ATP binding site [chemical binding]; other site 167555002402 Q-loop/lid; other site 167555002403 ABC transporter signature motif; other site 167555002404 Walker B; other site 167555002405 D-loop; other site 167555002406 H-loop/switch region; other site 167555002407 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 167555002408 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 167555002409 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167555002410 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 167555002411 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 167555002412 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 167555002413 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 167555002414 catalytic site [active] 167555002415 subunit interface [polypeptide binding]; other site 167555002416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 167555002417 anti sigma factor interaction site; other site 167555002418 regulatory phosphorylation site [posttranslational modification]; other site 167555002419 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 167555002420 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 167555002421 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 167555002422 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167555002423 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 167555002424 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 167555002425 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 167555002426 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 167555002427 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 167555002428 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 167555002429 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 167555002430 generic binding surface I; other site 167555002431 generic binding surface II; other site 167555002432 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 167555002433 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 167555002434 16S/18S rRNA binding site [nucleotide binding]; other site 167555002435 S13e-L30e interaction site [polypeptide binding]; other site 167555002436 25S rRNA binding site [nucleotide binding]; other site 167555002437 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 167555002438 RuvA N terminal domain; Region: RuvA_N; pfam01330 167555002439 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 167555002440 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167555002441 EamA-like transporter family; Region: EamA; cl01037 167555002442 EamA-like transporter family; Region: EamA; cl01037 167555002443 DNA primase; Validated; Region: dnaG; PRK05667 167555002444 CHC2 zinc finger; Region: zf-CHC2; cl15369 167555002445 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 167555002446 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 167555002447 active site 167555002448 metal binding site [ion binding]; metal-binding site 167555002449 interdomain interaction site; other site 167555002450 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 167555002451 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 167555002452 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 167555002453 active site 167555002454 DNA binding site [nucleotide binding] 167555002455 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167555002456 Catalytic site [active] 167555002457 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 167555002458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555002459 S-adenosylmethionine binding site [chemical binding]; other site 167555002460 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 167555002461 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 167555002462 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 167555002463 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 167555002464 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 167555002465 alpha subunit interface [polypeptide binding]; other site 167555002466 TPP binding site [chemical binding]; other site 167555002467 heterodimer interface [polypeptide binding]; other site 167555002468 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167555002469 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 167555002470 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167555002471 Protein export membrane protein; Region: SecD_SecF; cl14618 167555002472 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 167555002473 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167555002474 Protein export membrane protein; Region: SecD_SecF; cl14618 167555002475 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 167555002476 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 167555002477 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 167555002478 PetN; Region: PetN; cl15376 167555002479 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 167555002480 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555002481 oligomer interface [polypeptide binding]; other site 167555002482 active site residues [active] 167555002483 cell division protein; Validated; Region: ftsH; CHL00176 167555002484 FtsH Extracellular; Region: FtsH_ext; pfam06480 167555002485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555002486 Walker A motif; other site 167555002487 ATP binding site [chemical binding]; other site 167555002488 Walker B motif; other site 167555002489 arginine finger; other site 167555002490 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555002491 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 167555002492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167555002493 FtsX-like permease family; Region: FtsX; pfam02687 167555002494 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 167555002495 pyruvate kinase; Provisional; Region: PRK05826 167555002496 domain interfaces; other site 167555002497 active site 167555002498 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167555002499 YGGT family; Region: YGGT; cl00508 167555002500 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 167555002501 threonine dehydratase; Reviewed; Region: PRK09224 167555002502 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 167555002503 tetramer interface [polypeptide binding]; other site 167555002504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555002505 catalytic residue [active] 167555002506 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 167555002507 putative Ile/Val binding site [chemical binding]; other site 167555002508 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 167555002509 putative Ile/Val binding site [chemical binding]; other site 167555002510 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 167555002511 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 167555002512 TPP-binding site; other site 167555002513 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167555002514 PYR/PP interface [polypeptide binding]; other site 167555002515 dimer interface [polypeptide binding]; other site 167555002516 TPP binding site [chemical binding]; other site 167555002517 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167555002518 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 167555002519 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 167555002520 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 167555002521 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555002522 catalytic triad [active] 167555002523 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 167555002524 heat shock protein 90; Provisional; Region: PRK05218 167555002525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555002526 ATP binding site [chemical binding]; other site 167555002527 Mg2+ binding site [ion binding]; other site 167555002528 G-X-G motif; other site 167555002529 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 167555002530 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 167555002531 dimer interface [polypeptide binding]; other site 167555002532 motif 1; other site 167555002533 active site 167555002534 motif 2; other site 167555002535 motif 3; other site 167555002536 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 167555002537 active site 167555002538 dimerization interface [polypeptide binding]; other site 167555002539 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 167555002540 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 167555002541 Walker A/P-loop; other site 167555002542 ATP binding site [chemical binding]; other site 167555002543 Q-loop/lid; other site 167555002544 ABC transporter signature motif; other site 167555002545 Walker B; other site 167555002546 D-loop; other site 167555002547 H-loop/switch region; other site 167555002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555002549 dimer interface [polypeptide binding]; other site 167555002550 conserved gate region; other site 167555002551 putative PBP binding loops; other site 167555002552 ABC-ATPase subunit interface; other site 167555002553 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 167555002554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555002555 dimer interface [polypeptide binding]; other site 167555002556 conserved gate region; other site 167555002557 putative PBP binding loops; other site 167555002558 ABC-ATPase subunit interface; other site 167555002559 molecular chaperone DnaK; Provisional; Region: PRK13410 167555002560 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 167555002561 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555002562 HSP70 interaction site [polypeptide binding]; other site 167555002563 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167555002564 substrate binding site [polypeptide binding]; other site 167555002565 dimer interface [polypeptide binding]; other site 167555002566 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 167555002567 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 167555002568 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 167555002569 putative active site [active] 167555002570 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167555002571 active site 167555002572 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 167555002573 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 167555002574 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 167555002575 dimerization interface [polypeptide binding]; other site 167555002576 active site 167555002577 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 167555002578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002579 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 167555002580 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 167555002581 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 167555002582 active site 167555002583 substrate binding site [chemical binding]; other site 167555002584 cosubstrate binding site; other site 167555002585 catalytic site [active] 167555002586 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 167555002587 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 167555002588 active site 167555002589 dimer interface [polypeptide binding]; other site 167555002590 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 167555002591 dimer interface [polypeptide binding]; other site 167555002592 active site 167555002593 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 167555002594 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 167555002595 HIGH motif; other site 167555002596 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555002597 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555002598 active site 167555002599 KMSKS motif; other site 167555002600 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 167555002601 tRNA binding surface [nucleotide binding]; other site 167555002602 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 167555002603 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 167555002604 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 167555002605 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167555002606 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555002607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555002608 catalytic residue [active] 167555002609 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 167555002610 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 167555002611 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 167555002612 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 167555002613 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 167555002614 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 167555002615 active site 167555002616 (T/H)XGH motif; other site 167555002617 Flavin Reductases; Region: FlaRed; cl00801 167555002618 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 167555002619 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 167555002620 GIY-YIG motif/motif A; other site 167555002621 active site 167555002622 catalytic site [active] 167555002623 putative DNA binding site [nucleotide binding]; other site 167555002624 metal binding site [ion binding]; metal-binding site 167555002625 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 167555002626 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 167555002627 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 167555002628 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 167555002629 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 167555002630 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002631 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 167555002632 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002633 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002634 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 167555002635 homodimer interface [polypeptide binding]; other site 167555002636 substrate-cofactor binding pocket; other site 167555002637 Aminotransferase class IV; Region: Aminotran_4; pfam01063 167555002638 catalytic residue [active] 167555002639 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 167555002640 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 167555002641 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 167555002642 substrate binding pocket [chemical binding]; other site 167555002643 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 167555002644 B12 binding site [chemical binding]; other site 167555002645 cobalt ligand [ion binding]; other site 167555002646 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 167555002647 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 167555002648 ATP adenylyltransferase; Region: ATP_transf; pfam09830 167555002649 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555002650 HSP70 interaction site [polypeptide binding]; other site 167555002651 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 167555002652 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 167555002653 putative tRNA-binding site [nucleotide binding]; other site 167555002654 B3/4 domain; Region: B3_4; cl11458 167555002655 tRNA synthetase B5 domain; Region: B5; cl08394 167555002656 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 167555002657 dimer interface [polypeptide binding]; other site 167555002658 motif 1; other site 167555002659 motif 3; other site 167555002660 motif 2; other site 167555002661 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 167555002662 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 167555002663 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 167555002664 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167555002665 RNB domain; Region: RNB; pfam00773 167555002666 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 167555002667 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 167555002668 active site 167555002669 HIGH motif; other site 167555002670 KMSKS motif; other site 167555002671 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 167555002672 tRNA binding surface [nucleotide binding]; other site 167555002673 anticodon binding site; other site 167555002674 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 167555002675 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 167555002676 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 167555002677 homotrimer interface [polypeptide binding]; other site 167555002678 Walker A motif; other site 167555002679 GTP binding site [chemical binding]; other site 167555002680 Walker B motif; other site 167555002681 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167555002682 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 167555002683 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 167555002684 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167555002685 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 167555002686 dimer interface [polypeptide binding]; other site 167555002687 decamer (pentamer of dimers) interface [polypeptide binding]; other site 167555002688 catalytic triad [active] 167555002689 peroxidatic and resolving cysteines [active] 167555002690 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167555002691 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167555002692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555002693 Walker A motif; other site 167555002694 ATP binding site [chemical binding]; other site 167555002695 Walker B motif; other site 167555002696 arginine finger; other site 167555002697 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555002698 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 167555002699 Protein of unknown function (DUF565); Region: DUF565; pfam04483 167555002700 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167555002701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555002702 motif II; other site 167555002703 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 167555002704 DHH family; Region: DHH; pfam01368 167555002705 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167555002706 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167555002707 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167555002708 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167555002709 RNB domain; Region: RNB; pfam00773 167555002710 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 167555002711 RNA binding site [nucleotide binding]; other site 167555002712 aromatic acid decarboxylase; Validated; Region: PRK05920 167555002713 Flavoprotein; Region: Flavoprotein; cl08021 167555002714 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 167555002715 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 167555002716 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 167555002717 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 167555002718 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 167555002719 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 167555002720 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 167555002721 putative active site [active] 167555002722 substrate binding site [chemical binding]; other site 167555002723 putative cosubstrate binding site; other site 167555002724 catalytic site [active] 167555002725 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 167555002726 substrate binding site [chemical binding]; other site 167555002727 Integral membrane protein TerC family; Region: TerC; cl10468 167555002728 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 167555002729 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 167555002730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555002731 ATP binding site [chemical binding]; other site 167555002732 putative Mg++ binding site [ion binding]; other site 167555002733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555002734 nucleotide binding region [chemical binding]; other site 167555002735 ATP-binding site [chemical binding]; other site 167555002736 TRCF domain; Region: TRCF; cl04088 167555002737 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555002739 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 167555002740 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 167555002741 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555002742 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 167555002743 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 167555002744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002746 dihydrodipicolinate reductase; Provisional; Region: PRK00048 167555002747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002748 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 167555002749 magnesium chelatase subunit H; Provisional; Region: PRK12493 167555002750 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 167555002751 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002752 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002753 dihydropteroate synthase; Region: DHPS; TIGR01496 167555002754 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 167555002755 substrate binding pocket [chemical binding]; other site 167555002756 dimer interface [polypeptide binding]; other site 167555002757 inhibitor binding site; inhibition site 167555002758 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 167555002759 substrate binding site [chemical binding]; other site 167555002760 dimer interface [polypeptide binding]; other site 167555002761 catalytic triad [active] 167555002762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555002763 RNA binding surface [nucleotide binding]; other site 167555002764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555002765 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555002766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002767 Walker A/P-loop; other site 167555002768 ATP binding site [chemical binding]; other site 167555002769 Q-loop/lid; other site 167555002770 ABC transporter signature motif; other site 167555002771 Walker B; other site 167555002772 D-loop; other site 167555002773 H-loop/switch region; other site 167555002774 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167555002775 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167555002776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555002777 active site 167555002778 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 167555002779 NmrA-like family; Region: NmrA; pfam05368 167555002780 NADP binding site [chemical binding]; other site 167555002781 active site 167555002782 regulatory binding site [polypeptide binding]; other site 167555002783 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 167555002784 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167555002785 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167555002786 putative di-iron ligands [ion binding]; other site 167555002787 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167555002788 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 167555002789 active site pocket [active] 167555002790 oxyanion hole [active] 167555002791 catalytic triad [active] 167555002792 active site nucleophile [active] 167555002793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002794 NAD(P) binding site [chemical binding]; other site 167555002795 active site 167555002796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167555002797 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 167555002798 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167555002799 Ion channel; Region: Ion_trans_2; cl11596 167555002800 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167555002801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002802 T5orf172 domain; Region: T5orf172; cl11176 167555002803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 167555002804 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 167555002805 Protein of unknown function, DUF393; Region: DUF393; cl01136 167555002806 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167555002807 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167555002808 nucleotide binding pocket [chemical binding]; other site 167555002809 K-X-D-G motif; other site 167555002810 catalytic site [active] 167555002811 putative high light inducible protein; Region: PHA02337 167555002812 putative high light inducible protein; Region: PHA02337 167555002813 putative high light inducible protein; Region: PHA02337 167555002814 putative high light inducible protein; Region: PHA02337 167555002815 putative high light inducible protein; Region: PHA02337 167555002816 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 167555002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555002818 primosome assembly protein PriA; Validated; Region: PRK05580 167555002819 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167555002820 nucleotide binding pocket [chemical binding]; other site 167555002821 Domain of unknown function DUF77; Region: DUF77; cl00307 167555002822 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002823 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 167555002824 dinuclear metal binding motif [ion binding]; other site 167555002825 putative high light inducible protein; Region: PHA02337 167555002826 putative high light inducible protein; Region: PHA02337 167555002827 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167555002828 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 167555002829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167555002830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555002831 active site 167555002832 phosphorylation site [posttranslational modification] 167555002833 intermolecular recognition site; other site 167555002834 dimerization interface [polypeptide binding]; other site 167555002835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555002836 DNA binding site [nucleotide binding] 167555002837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555002838 dimer interface [polypeptide binding]; other site 167555002839 phosphorylation site [posttranslational modification] 167555002840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555002841 ATP binding site [chemical binding]; other site 167555002842 Mg2+ binding site [ion binding]; other site 167555002843 G-X-G motif; other site 167555002844 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 167555002845 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167555002846 Chromate transporter; Region: Chromate_transp; pfam02417 167555002847 Chromate transporter; Region: Chromate_transp; pfam02417 167555002848 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167555002849 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 167555002850 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167555002851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 167555002852 dimerization interface [polypeptide binding]; other site 167555002853 putative DNA binding site [nucleotide binding]; other site 167555002854 putative Zn2+ binding site [ion binding]; other site 167555002855 Membrane transport protein; Region: Mem_trans; cl09117 167555002856 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555002857 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 167555002858 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167555002859 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 167555002860 MAPEG family; Region: MAPEG; cl09190 167555002861 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167555002862 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 167555002863 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 167555002864 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 167555002865 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002866 Membrane transport protein; Region: Mem_trans; cl09117 167555002867 Rhomboid family; Region: Rhomboid; cl11446 167555002868 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 167555002869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002870 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 167555002871 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 167555002872 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002873 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 167555002874 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 167555002875 putative FMN binding site [chemical binding]; other site 167555002876 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 167555002877 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555002878 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555002879 putative high light inducible protein; Region: PHA02337 167555002880 putative high light inducible protein; Region: PHA02337 167555002881 putative high light inducible protein; Region: PHA02337 167555002882 putative high light inducible protein; Region: PHA02337 167555002883 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 167555002884 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 167555002885 catalytic triad [active] 167555002886 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 167555002887 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 167555002888 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 167555002889 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 167555002890 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 167555002891 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002892 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 167555002893 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 167555002894 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167555002895 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 167555002896 putative high light inducible protein; Region: PHA02337 167555002897 putative high light inducible protein; Region: PHA02337 167555002898 putative high light inducible protein; Region: PHA02337 167555002899 putative high light inducible protein; Region: PHA02337 167555002900 putative high light inducible protein; Region: PHA02337 167555002901 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167555002902 RF-1 domain; Region: RF-1; cl02875 167555002903 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167555002904 protein I interface; other site 167555002905 D2 interface; other site 167555002906 protein T interface; other site 167555002907 chlorophyll binding site; other site 167555002908 beta carotene binding site; other site 167555002909 pheophytin binding site; other site 167555002910 manganese-stabilizing polypeptide interface; other site 167555002911 CP43 interface; other site 167555002912 protein L interface; other site 167555002913 oxygen evolving complex binding site; other site 167555002914 bromide binding site; other site 167555002915 quinone binding site; other site 167555002916 Fe binding site [ion binding]; other site 167555002917 core light harvesting interface; other site 167555002918 cytochrome b559 alpha subunit interface; other site 167555002919 cytochrome c-550 interface; other site 167555002920 protein J interface; other site 167555002921 endonuclease VIII; Provisional; Region: PRK10445 167555002922 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 167555002923 DNA binding site [nucleotide binding] 167555002924 catalytic residue [active] 167555002925 H2TH interface [polypeptide binding]; other site 167555002926 putative catalytic residues [active] 167555002927 intercalation triad [nucleotide binding]; other site 167555002928 substrate specificity determining residue; other site 167555002929 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167555002930 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 167555002931 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555002932 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167555002933 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 167555002934 putative high light inducible protein; Region: PHA02337 167555002935 putative high light inducible protein; Region: PHA02337 167555002936 putative high light inducible protein; Region: PHA02337 167555002937 putative high light inducible protein; Region: PHA02337 167555002938 putative high light inducible protein; Region: PHA02337 167555002939 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555002940 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555002941 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002942 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555002943 Domain of unknown function (DUF296); Region: DUF296; cl00720 167555002944 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 167555002945 GSH binding site [chemical binding]; other site 167555002946 catalytic residues [active] 167555002947 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555002948 Cupin domain; Region: Cupin_2; cl09118 167555002949 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 167555002950 Cupin domain; Region: Cupin_2; cl09118 167555002951 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167555002952 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555002953 catalytic loop [active] 167555002954 iron binding site [ion binding]; other site 167555002955 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 167555002956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555002957 RNA binding surface [nucleotide binding]; other site 167555002958 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 167555002959 probable active site [active] 167555002960 putative high light inducible protein; Region: PHA02337 167555002961 putative high light inducible protein; Region: PHA02337 167555002962 putative high light inducible protein; Region: PHA02337 167555002963 putative high light inducible protein; Region: PHA02337 167555002964 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555002965 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 167555002966 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 167555002967 Walker A/P-loop; other site 167555002968 ATP binding site [chemical binding]; other site 167555002969 Q-loop/lid; other site 167555002970 ABC transporter signature motif; other site 167555002971 Walker B; other site 167555002972 D-loop; other site 167555002973 H-loop/switch region; other site 167555002974 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 167555002975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555002976 dimer interface [polypeptide binding]; other site 167555002977 conserved gate region; other site 167555002978 putative PBP binding loops; other site 167555002979 ABC-ATPase subunit interface; other site 167555002980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555002981 dimer interface [polypeptide binding]; other site 167555002982 conserved gate region; other site 167555002983 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 167555002984 ABC-ATPase subunit interface; other site 167555002985 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 167555002986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 167555002987 substrate binding pocket [chemical binding]; other site 167555002988 membrane-bound complex binding site; other site 167555002989 hinge residues; other site 167555002990 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 167555002991 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 167555002992 HupE / UreJ protein; Region: HupE_UreJ; cl01011 167555002993 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167555002994 Permease family; Region: Xan_ur_permease; cl00967 167555002995 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167555002996 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167555002997 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 167555002998 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 167555002999 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 167555003000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167555003002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555003003 active site 167555003004 phosphorylation site [posttranslational modification] 167555003005 intermolecular recognition site; other site 167555003006 dimerization interface [polypeptide binding]; other site 167555003007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555003008 DNA binding site [nucleotide binding] 167555003009 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 167555003010 putative GSH binding site [chemical binding]; other site 167555003011 catalytic residues [active] 167555003012 BolA-like protein; Region: BolA; cl00386 167555003013 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167555003014 putative acyl-acceptor binding pocket; other site 167555003015 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 167555003016 active site 167555003017 hydrophilic channel; other site 167555003018 dimerization interface [polypeptide binding]; other site 167555003019 catalytic residues [active] 167555003020 active site lid [active] 167555003021 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 167555003022 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 167555003023 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 167555003024 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 167555003025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003027 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 167555003028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003029 ATP binding site [chemical binding]; other site 167555003030 putative Mg++ binding site [ion binding]; other site 167555003031 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 167555003032 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 167555003033 ATP binding site [chemical binding]; other site 167555003034 Mg++ binding site [ion binding]; other site 167555003035 motif III; other site 167555003036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555003037 nucleotide binding region [chemical binding]; other site 167555003038 ATP-binding site [chemical binding]; other site 167555003039 DbpA RNA binding domain; Region: DbpA; pfam03880 167555003040 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555003041 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555003042 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 167555003043 Walker A/P-loop; other site 167555003044 ATP binding site [chemical binding]; other site 167555003045 Q-loop/lid; other site 167555003046 ABC transporter signature motif; other site 167555003047 Walker B; other site 167555003048 D-loop; other site 167555003049 H-loop/switch region; other site 167555003050 PsbP; Region: PsbP; cl03356 167555003051 recombination protein RecR; Reviewed; Region: recR; PRK00076 167555003052 RecR protein; Region: RecR; pfam02132 167555003053 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 167555003054 putative active site [active] 167555003055 putative metal-binding site [ion binding]; other site 167555003056 tetramer interface [polypeptide binding]; other site 167555003057 lipoyl synthase; Provisional; Region: PRK12928 167555003058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 167555003059 FeS/SAM binding site; other site 167555003060 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 167555003061 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 167555003062 active site residue [active] 167555003063 biotin synthase; Region: bioB; TIGR00433 167555003064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555003065 FeS/SAM binding site; other site 167555003066 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 167555003067 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 167555003068 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 167555003069 catalytic residue [active] 167555003070 putative FPP diphosphate binding site; other site 167555003071 putative FPP binding hydrophobic cleft; other site 167555003072 dimer interface [polypeptide binding]; other site 167555003073 putative IPP diphosphate binding site; other site 167555003074 TIGR00159 family protein; Region: TIGR00159 167555003075 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 167555003076 diaminopimelate decarboxylase; Region: lysA; TIGR01048 167555003077 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 167555003078 active site 167555003079 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555003080 substrate binding site [chemical binding]; other site 167555003081 catalytic residues [active] 167555003082 dimer interface [polypeptide binding]; other site 167555003083 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 167555003084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167555003085 Coenzyme A binding pocket [chemical binding]; other site 167555003086 Clp protease ATP binding subunit; Region: clpC; CHL00095 167555003087 Clp amino terminal domain; Region: Clp_N; pfam02861 167555003088 Clp amino terminal domain; Region: Clp_N; pfam02861 167555003089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003090 Walker A motif; other site 167555003091 ATP binding site [chemical binding]; other site 167555003092 Walker B motif; other site 167555003093 arginine finger; other site 167555003094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003095 Walker A motif; other site 167555003096 ATP binding site [chemical binding]; other site 167555003097 Walker B motif; other site 167555003098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167555003099 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 167555003100 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 167555003101 putative active site [active] 167555003102 metal binding site [ion binding]; metal-binding site 167555003103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167555003104 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167555003105 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 167555003106 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 167555003107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555003108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555003109 catalytic residue [active] 167555003110 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167555003111 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 167555003112 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 167555003113 Helix-turn-helix domains; Region: HTH; cl00088 167555003114 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 167555003115 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555003116 ribose-phosphate pyrophosphokinase; Region: PLN02369 167555003117 aminopeptidase N; Provisional; Region: pepN; PRK14015 167555003118 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 167555003119 Zn binding site [ion binding]; other site 167555003120 adaptive-response sensory kinase; Validated; Region: PRK09303 167555003121 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167555003122 tetramer interface [polypeptide binding]; other site 167555003123 dimer interface [polypeptide binding]; other site 167555003124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555003125 dimer interface [polypeptide binding]; other site 167555003126 phosphorylation site [posttranslational modification] 167555003127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555003128 ATP binding site [chemical binding]; other site 167555003129 Mg2+ binding site [ion binding]; other site 167555003130 G-X-G motif; other site 167555003131 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 167555003132 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 167555003133 dimerization interface [polypeptide binding]; other site 167555003134 FAD binding pocket [chemical binding]; other site 167555003135 FAD binding motif [chemical binding]; other site 167555003136 catalytic residues [active] 167555003137 NAD binding pocket [chemical binding]; other site 167555003138 phosphate binding motif [ion binding]; other site 167555003139 beta-alpha-beta structure motif; other site 167555003140 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 167555003141 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 167555003142 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 167555003143 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 167555003144 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 167555003145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003146 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 167555003147 catalytic triad [active] 167555003148 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 167555003149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003150 Divergent PAP2 family; Region: DUF212; cl00855 167555003151 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167555003152 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167555003153 substrate binding pocket [chemical binding]; other site 167555003154 chain length determination region; other site 167555003155 substrate-Mg2+ binding site; other site 167555003156 catalytic residues [active] 167555003157 aspartate-rich region 1; other site 167555003158 active site lid residues [active] 167555003159 aspartate-rich region 2; other site 167555003160 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 167555003161 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 167555003162 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 167555003163 homodimer interface [polypeptide binding]; other site 167555003164 NADP binding site [chemical binding]; other site 167555003165 substrate binding site [chemical binding]; other site 167555003166 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 167555003167 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 167555003168 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167555003169 Zn2+ binding site [ion binding]; other site 167555003170 Mg2+ binding site [ion binding]; other site 167555003171 2-isopropylmalate synthase; Validated; Region: PRK00915 167555003172 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 167555003173 active site 167555003174 catalytic residues [active] 167555003175 metal binding site [ion binding]; metal-binding site 167555003176 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 167555003177 Uncharacterized conserved protein [Function unknown]; Region: COG1543 167555003178 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 167555003179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003180 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167555003181 DNA gyrase subunit A; Validated; Region: PRK05560 167555003182 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 167555003183 CAP-like domain; other site 167555003184 active site 167555003185 primary dimer interface [polypeptide binding]; other site 167555003186 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003187 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003188 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003192 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 167555003193 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 167555003194 active site 167555003195 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 167555003196 catalytic residues [active] 167555003197 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167555003198 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167555003199 putative active site [active] 167555003200 oxyanion strand; other site 167555003201 catalytic triad [active] 167555003202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003203 S-adenosylmethionine binding site [chemical binding]; other site 167555003204 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 167555003205 Cytochrome c; Region: Cytochrom_C; cl11414 167555003206 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 167555003207 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167555003208 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 167555003209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003210 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 167555003211 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 167555003212 active site 167555003213 putative DNA-binding cleft [nucleotide binding]; other site 167555003214 dimer interface [polypeptide binding]; other site 167555003215 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 167555003216 Fe-S metabolism associated domain; Region: SufE; cl00951 167555003217 homoserine dehydrogenase; Provisional; Region: PRK06349 167555003218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003219 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 167555003220 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 167555003221 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 167555003222 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 167555003223 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 167555003224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555003225 dimer interface [polypeptide binding]; other site 167555003226 conserved gate region; other site 167555003227 putative PBP binding loops; other site 167555003228 ABC-ATPase subunit interface; other site 167555003229 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167555003230 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 167555003231 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167555003232 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167555003233 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 167555003234 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167555003235 substrate binding site [chemical binding]; other site 167555003236 ATP binding site [chemical binding]; other site 167555003237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003238 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003239 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 167555003240 Protein of unknown function, DUF393; Region: DUF393; cl01136 167555003241 Photosystem II protein; Region: PSII; cl08223 167555003242 Photosystem II protein; Region: PSII; cl08223 167555003243 Photosystem II protein; Region: PSII; cl08223 167555003244 Photosystem II protein; Region: PSII; cl08223 167555003245 Photosystem II protein; Region: PSII; cl08223 167555003246 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 167555003247 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 167555003248 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 167555003249 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 167555003250 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 167555003251 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555003252 catalytic triad [active] 167555003253 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 167555003254 short chain dehydrogenase; Provisional; Region: PRK06197 167555003255 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 167555003256 putative NAD(P) binding site [chemical binding]; other site 167555003257 active site 167555003258 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 167555003259 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 167555003260 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 167555003261 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 167555003262 Domain of unknown function (DUF404); Region: DUF404; pfam04169 167555003263 Domain of unknown function (DUF407); Region: DUF407; pfam04174 167555003264 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167555003265 protein I interface; other site 167555003266 D2 interface; other site 167555003267 protein T interface; other site 167555003268 chlorophyll binding site; other site 167555003269 beta carotene binding site; other site 167555003270 pheophytin binding site; other site 167555003271 manganese-stabilizing polypeptide interface; other site 167555003272 CP43 interface; other site 167555003273 protein L interface; other site 167555003274 oxygen evolving complex binding site; other site 167555003275 bromide binding site; other site 167555003276 quinone binding site; other site 167555003277 Fe binding site [ion binding]; other site 167555003278 core light harvesting interface; other site 167555003279 cytochrome b559 alpha subunit interface; other site 167555003280 cytochrome c-550 interface; other site 167555003281 protein J interface; other site 167555003282 Family of unknown function (DUF500); Region: DUF500; cl01109 167555003283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167555003284 binding surface 167555003285 TPR motif; other site 167555003286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003287 binding surface 167555003288 TPR motif; other site 167555003289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003290 binding surface 167555003291 TPR motif; other site 167555003292 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 167555003293 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555003294 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555003295 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 167555003296 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 167555003297 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167555003298 GTP-binding protein YchF; Reviewed; Region: PRK09601 167555003299 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 167555003300 G1 box; other site 167555003301 GTP/Mg2+ binding site [chemical binding]; other site 167555003302 Switch I region; other site 167555003303 G2 box; other site 167555003304 Switch II region; other site 167555003305 G3 box; other site 167555003306 G4 box; other site 167555003307 G5 box; other site 167555003308 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 167555003309 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 167555003310 DNA polymerase I; Provisional; Region: PRK05755 167555003311 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 167555003312 active site 167555003313 metal binding site 1 [ion binding]; metal-binding site 167555003314 putative 5' ssDNA interaction site; other site 167555003315 metal binding site 3; metal-binding site 167555003316 metal binding site 2 [ion binding]; metal-binding site 167555003317 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 167555003318 putative DNA binding site [nucleotide binding]; other site 167555003319 putative metal binding site [ion binding]; other site 167555003320 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 167555003321 active site 167555003322 catalytic site [active] 167555003323 substrate binding site [chemical binding]; other site 167555003324 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 167555003325 active site 167555003326 DNA binding site [nucleotide binding] 167555003327 catalytic site [active] 167555003328 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 167555003329 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167555003330 active site 167555003331 HIGH motif; other site 167555003332 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167555003333 KMSKS motif; other site 167555003334 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167555003335 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 167555003336 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 167555003337 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 167555003338 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 167555003339 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 167555003340 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 167555003341 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 167555003342 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 167555003343 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 167555003344 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 167555003345 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 167555003346 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167555003347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003348 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555003349 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 167555003350 rRNA binding site [nucleotide binding]; other site 167555003351 predicted 30S ribosome binding site; other site 167555003352 Ycf39; Provisional; Region: ycf39; CHL00194 167555003353 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167555003354 NAD(P) binding site [chemical binding]; other site 167555003355 putative active site [active] 167555003356 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167555003357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167555003358 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 167555003359 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 167555003360 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 167555003361 putative valine binding site [chemical binding]; other site 167555003362 dimer interface [polypeptide binding]; other site 167555003363 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 167555003364 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167555003365 active site 167555003366 Ycf4; Region: Ycf4; cl03567 167555003367 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 167555003368 pheophytin binding site; other site 167555003369 chlorophyll binding site; other site 167555003370 quinone binding site; other site 167555003371 Fe binding site [ion binding]; other site 167555003372 Photosystem II protein; Region: PSII; cl08223 167555003373 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 167555003374 Maf-like protein; Region: Maf; pfam02545 167555003375 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 167555003376 active site 167555003377 dimer interface [polypeptide binding]; other site 167555003378 cobyric acid synthase; Provisional; Region: PRK00784 167555003379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003380 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 167555003381 catalytic triad [active] 167555003382 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555003383 catalytic loop [active] 167555003384 iron binding site [ion binding]; other site 167555003385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003386 S-adenosylmethionine binding site [chemical binding]; other site 167555003387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003388 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 167555003389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 167555003390 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 167555003391 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 167555003392 dimer interface [polypeptide binding]; other site 167555003393 motif 1; other site 167555003394 active site 167555003395 motif 2; other site 167555003396 motif 3; other site 167555003397 conserved hypothetical protein; Region: TIGR02466 167555003398 conserved hypothetical protein; Region: TIGR02466 167555003399 MAEBL; Provisional; Region: PTZ00121 167555003400 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 167555003401 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555003402 catalytic triad [active] 167555003403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003404 binding surface 167555003405 TPR motif; other site 167555003406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003407 binding surface 167555003408 TPR motif; other site 167555003409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003410 S-adenosylmethionine binding site [chemical binding]; other site 167555003411 PQ loop repeat; Region: PQ-loop; cl12056 167555003412 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 167555003413 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167555003414 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 167555003415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555003416 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 167555003417 putative ADP-binding pocket [chemical binding]; other site 167555003418 EamA-like transporter family; Region: EamA; cl01037 167555003419 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 167555003420 EamA-like transporter family; Region: EamA; cl01037 167555003421 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 167555003422 tandem repeat interface [polypeptide binding]; other site 167555003423 oligomer interface [polypeptide binding]; other site 167555003424 active site residues [active] 167555003425 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 167555003426 homotrimer interaction site [polypeptide binding]; other site 167555003427 active site 167555003428 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 167555003429 Ribonuclease P; Region: Ribonuclease_P; cl00457 167555003430 Bacterial PH domain; Region: DUF304; cl01348 167555003431 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 167555003432 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167555003433 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167555003434 Ycf46; Provisional; Region: ycf46; CHL00195 167555003435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003436 ATP binding site [chemical binding]; other site 167555003437 Walker A motif; other site 167555003438 Walker B motif; other site 167555003439 arginine finger; other site 167555003440 seryl-tRNA synthetase; Provisional; Region: PRK05431 167555003441 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 167555003442 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 167555003443 dimer interface [polypeptide binding]; other site 167555003444 active site 167555003445 motif 1; other site 167555003446 motif 2; other site 167555003447 motif 3; other site 167555003448 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 167555003449 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 167555003450 active site 167555003451 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 167555003452 protein binding site [polypeptide binding]; other site 167555003453 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 167555003454 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 167555003455 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 167555003456 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 167555003457 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 167555003458 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 167555003459 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 167555003460 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 167555003461 putative nucleic acid binding region [nucleotide binding]; other site 167555003462 G-X-X-G motif; other site 167555003463 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 167555003464 RNA binding site [nucleotide binding]; other site 167555003465 domain interface; other site 167555003466 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 167555003467 active site 167555003468 Predicted methyltransferases [General function prediction only]; Region: COG0313 167555003469 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 167555003470 acetylglucosaminyltransferase family protein; Provisional; Region: PLN03183 167555003471 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 167555003472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003473 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 167555003474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003475 binding surface 167555003476 TPR motif; other site 167555003477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003478 binding surface 167555003479 TPR motif; other site 167555003480 conserved hypothetical protein; Region: TIGR02466 167555003481 SOS regulatory protein LexA; Region: lexA; TIGR00498 167555003482 Helix-turn-helix domains; Region: HTH; cl00088 167555003483 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167555003484 Catalytic site [active] 167555003485 ornithine carbamoyltransferase; Provisional; Region: PRK00779 167555003486 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167555003487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003488 FtsH Extracellular; Region: FtsH_ext; pfam06480 167555003489 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167555003490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003491 Walker A motif; other site 167555003492 ATP binding site [chemical binding]; other site 167555003493 Walker B motif; other site 167555003494 arginine finger; other site 167555003495 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555003496 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 167555003497 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 167555003498 catalytic motif [active] 167555003499 Zn binding site [ion binding]; other site 167555003500 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 167555003501 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 167555003502 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 167555003503 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 167555003504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003505 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 167555003506 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 167555003507 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 167555003508 dimer interface [polypeptide binding]; other site 167555003509 motif 1; other site 167555003510 active site 167555003511 motif 2; other site 167555003512 motif 3; other site 167555003513 Survival protein SurE; Region: SurE; cl00448 167555003514 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 167555003515 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 167555003516 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 167555003517 active site 167555003518 Riboflavin kinase; Region: Flavokinase; cl03312 167555003519 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 167555003520 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 167555003521 thiamine phosphate binding site [chemical binding]; other site 167555003522 active site 167555003523 pyrophosphate binding site [ion binding]; other site 167555003524 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 167555003525 thiS-thiF/thiG interaction site; other site 167555003526 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 167555003527 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 167555003528 AIR carboxylase; Region: AIRC; cl00310 167555003529 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 167555003530 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 167555003531 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 167555003532 homotrimer interaction site [polypeptide binding]; other site 167555003533 zinc binding site [ion binding]; other site 167555003534 CDP-binding sites; other site 167555003535 GTPase Era; Reviewed; Region: era; PRK00089 167555003536 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 167555003537 G1 box; other site 167555003538 GTP/Mg2+ binding site [chemical binding]; other site 167555003539 Switch I region; other site 167555003540 G2 box; other site 167555003541 Switch II region; other site 167555003542 G3 box; other site 167555003543 G4 box; other site 167555003544 G5 box; other site 167555003545 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 167555003546 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 167555003547 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 167555003548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003549 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 167555003550 signal recognition particle protein; Provisional; Region: PRK10867 167555003551 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 167555003552 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003553 Signal peptide binding domain; Region: SRP_SPB; pfam02978 167555003554 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 167555003555 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 167555003556 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 167555003557 tetramer interface [polypeptide binding]; other site 167555003558 TPP-binding site [chemical binding]; other site 167555003559 heterodimer interface [polypeptide binding]; other site 167555003560 phosphorylation loop region [posttranslational modification] 167555003561 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555003562 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555003563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555003564 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555003565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555003566 DNA binding residues [nucleotide binding] 167555003567 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 167555003568 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 167555003569 putative substrate binding site [chemical binding]; other site 167555003570 putative ATP binding site [chemical binding]; other site 167555003571 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 167555003572 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 167555003573 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 167555003574 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 167555003575 putative active site [active] 167555003576 catalytic triad [active] 167555003577 putative dimer interface [polypeptide binding]; other site 167555003578 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 167555003579 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 167555003580 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167555003581 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555003582 Catalytic site [active] 167555003583 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 167555003584 active site 167555003585 ribulose/triose binding site [chemical binding]; other site 167555003586 phosphate binding site [ion binding]; other site 167555003587 substrate (anthranilate) binding pocket [chemical binding]; other site 167555003588 product (indole) binding pocket [chemical binding]; other site 167555003589 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 167555003590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003592 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167555003593 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167555003594 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 167555003595 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 167555003596 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167555003597 hinge; other site 167555003598 active site 167555003599 acetylornithine aminotransferase; Provisional; Region: PRK02627 167555003600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167555003601 inhibitor-cofactor binding pocket; inhibition site 167555003602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555003603 catalytic residue [active] 167555003604 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 167555003605 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555003606 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167555003607 FAD binding domain; Region: FAD_binding_4; pfam01565 167555003608 cytosine deaminase-like protein; Validated; Region: PRK07583 167555003609 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 167555003610 active site 167555003611 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 167555003612 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167555003613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555003614 FeS/SAM binding site; other site 167555003615 TRAM domain; Region: TRAM; cl01282 167555003616 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 167555003617 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 167555003618 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555003619 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 167555003620 cell division protein FtsZ; Validated; Region: PRK09330 167555003621 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 167555003622 nucleotide binding site [chemical binding]; other site 167555003623 SulA interaction site; other site 167555003624 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 167555003625 oligomerization interface [polypeptide binding]; other site 167555003626 active site 167555003627 metal binding site [ion binding]; metal-binding site 167555003628 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 167555003629 HemN C-terminal region; Region: HemN_C; pfam06969 167555003630 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 167555003631 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 167555003632 putative active site [active] 167555003633 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555003634 oligomer interface [polypeptide binding]; other site 167555003635 active site residues [active] 167555003636 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555003637 oligomer interface [polypeptide binding]; other site 167555003638 active site residues [active] 167555003639 ketol-acid reductoisomerase; Provisional; Region: PRK05479 167555003640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003641 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 167555003642 CobD/Cbib protein; Region: CobD_Cbib; cl00561 167555003643 Bacterial sugar transferase; Region: Bac_transf; cl00939 167555003644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555003645 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 167555003646 putative ADP-binding pocket [chemical binding]; other site 167555003647 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167555003648 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 167555003649 IHF dimer interface [polypeptide binding]; other site 167555003650 IHF - DNA interface [nucleotide binding]; other site 167555003651 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 167555003652 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 167555003653 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 167555003654 active site 167555003655 catalytic site [active] 167555003656 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 167555003657 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 167555003658 Domain of unknown function DUF140; Region: DUF140; cl00510 167555003659 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 167555003660 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 167555003661 Domain of unknown function (DUF205); Region: DUF205; cl00410 167555003662 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 167555003663 active site 167555003664 dimer interface [polypeptide binding]; other site 167555003665 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 167555003666 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 167555003667 active site 167555003668 HIGH motif; other site 167555003669 dimer interface [polypeptide binding]; other site 167555003670 KMSKS motif; other site 167555003671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 167555003672 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 167555003673 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 167555003674 multifunctional aminopeptidase A; Provisional; Region: PRK00913 167555003675 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 167555003676 interface (dimer of trimers) [polypeptide binding]; other site 167555003677 Substrate-binding/catalytic site; other site 167555003678 Zn-binding sites [ion binding]; other site 167555003679 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167555003680 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167555003681 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555003682 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 167555003683 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 167555003684 active site 167555003685 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 167555003686 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 167555003687 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 167555003688 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 167555003689 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 167555003690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 167555003691 Surface antigen; Region: Bac_surface_Ag; cl03097 167555003692 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 167555003693 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 167555003694 ATP binding site [chemical binding]; other site 167555003695 active site 167555003696 substrate binding site [chemical binding]; other site 167555003697 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 167555003698 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 167555003699 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 167555003700 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167555003701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 167555003702 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 167555003703 dimerization interface [polypeptide binding]; other site 167555003704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 167555003705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555003706 dimer interface [polypeptide binding]; other site 167555003707 phosphorylation site [posttranslational modification] 167555003708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555003709 ATP binding site [chemical binding]; other site 167555003710 Mg2+ binding site [ion binding]; other site 167555003711 G-X-G motif; other site 167555003712 circadian clock protein KaiC; Reviewed; Region: PRK09302 167555003713 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 167555003714 Walker A motif; other site 167555003715 ATP binding site [chemical binding]; other site 167555003716 Walker B motif; other site 167555003717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003719 Walker A motif; other site 167555003720 Walker A motif; other site 167555003721 ATP binding site [chemical binding]; other site 167555003722 Walker B motif; other site 167555003723 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167555003724 tetramer interface [polypeptide binding]; other site 167555003725 dimer interface [polypeptide binding]; other site 167555003726 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 167555003727 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 167555003728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003729 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 167555003730 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 167555003731 RNA binding site [nucleotide binding]; other site 167555003732 active site 167555003733 Stage II sporulation protein; Region: SpoIID; pfam08486 167555003734 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167555003735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167555003736 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003737 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003738 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555003739 catalytic loop [active] 167555003740 iron binding site [ion binding]; other site 167555003741 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 167555003742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003743 S-adenosylmethionine binding site [chemical binding]; other site 167555003744 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 167555003745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555003746 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 167555003747 putative L-serine binding site [chemical binding]; other site 167555003748 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 167555003749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 167555003750 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 167555003751 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 167555003752 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555003753 GAF domain; Region: GAF; cl00853 167555003754 DoxX; Region: DoxX; cl00976 167555003755 OsmC-like protein; Region: OsmC; cl00767 167555003756 putative high light inducible protein; Region: PHA02337 167555003757 putative high light inducible protein; Region: PHA02337 167555003758 putative high light inducible protein; Region: PHA02337 167555003759 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 167555003760 putative high light inducible protein; Region: PHA02337 167555003761 putative high light inducible protein; Region: PHA02337 167555003762 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167555003763 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003764 Walker A/P-loop; other site 167555003765 ATP binding site [chemical binding]; other site 167555003766 ABC transporter signature motif; other site 167555003767 Walker B; other site 167555003768 D-loop; other site 167555003769 H-loop/switch region; other site 167555003770 ABC transporter; Region: ABC_tran_2; pfam12848 167555003771 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 167555003772 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 167555003773 Protein of unknown function (DUF805); Region: DUF805; cl01224 167555003774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003775 binding surface 167555003776 TPR motif; other site 167555003777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003778 binding surface 167555003779 TPR motif; other site 167555003780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003781 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 167555003782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003783 binding surface 167555003784 TPR motif; other site 167555003785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003786 binding surface 167555003787 TPR motif; other site 167555003788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003789 binding surface 167555003790 TPR motif; other site 167555003791 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 167555003792 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555003793 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 167555003794 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 167555003795 DNA binding site [nucleotide binding] 167555003796 active site 167555003797 Int/Topo IB signature motif; other site 167555003798 conserved hypothetical protein; Region: TIGR02466 167555003799 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167555003800 EVE domain; Region: EVE; cl00728 167555003801 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555003802 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 167555003803 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 167555003804 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 167555003805 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 167555003806 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 167555003807 Sulfatase; Region: Sulfatase; cl10460 167555003808 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 167555003809 Preprotein translocase SecG subunit; Region: SecG; cl09123 167555003810 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167555003811 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167555003812 ring oligomerisation interface [polypeptide binding]; other site 167555003813 ATP/Mg binding site [chemical binding]; other site 167555003814 stacking interactions; other site 167555003815 hinge regions; other site 167555003816 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 167555003817 oligomerisation interface [polypeptide binding]; other site 167555003818 mobile loop; other site 167555003819 roof hairpin; other site 167555003820 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 167555003821 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 167555003822 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 167555003823 alpha subunit interaction interface [polypeptide binding]; other site 167555003824 Walker A motif; other site 167555003825 ATP binding site [chemical binding]; other site 167555003826 Walker B motif; other site 167555003827 inhibitor binding site; inhibition site 167555003828 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167555003829 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 167555003830 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 167555003831 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 167555003832 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 167555003833 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 167555003834 proline aminopeptidase P II; Provisional; Region: PRK10879 167555003835 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 167555003836 active site 167555003837 Domain of unknown function DUF21; Region: DUF21; pfam01595 167555003838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167555003839 Predicted GTPase [General function prediction only]; Region: COG0218 167555003840 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 167555003841 G1 box; other site 167555003842 GTP/Mg2+ binding site [chemical binding]; other site 167555003843 Switch I region; other site 167555003844 G2 box; other site 167555003845 Switch II region; other site 167555003846 G3 box; other site 167555003847 G4 box; other site 167555003848 G5 box; other site 167555003849 Domain of unknown function (DUF697); Region: DUF697; cl12064 167555003850 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 167555003851 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 167555003852 active site 167555003853 (T/H)XGH motif; other site 167555003854 NAD synthetase; Provisional; Region: PRK13981 167555003855 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 167555003856 multimer interface [polypeptide binding]; other site 167555003857 active site 167555003858 catalytic triad [active] 167555003859 protein interface 1 [polypeptide binding]; other site 167555003860 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 167555003861 homodimer interface [polypeptide binding]; other site 167555003862 NAD binding pocket [chemical binding]; other site 167555003863 ATP binding pocket [chemical binding]; other site 167555003864 Mg binding site [ion binding]; other site 167555003865 active-site loop [active] 167555003866 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 167555003867 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 167555003868 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 167555003869 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 167555003870 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 167555003871 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 167555003872 beta subunit interaction interface [polypeptide binding]; other site 167555003873 Walker A motif; other site 167555003874 ATP binding site [chemical binding]; other site 167555003875 Walker B motif; other site 167555003876 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167555003877 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 167555003878 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 167555003879 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 167555003880 Plant ATP synthase F0; Region: YMF19; cl07975 167555003881 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 167555003882 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 167555003883 ATP synthase subunit C; Region: ATP-synt_C; cl00466 167555003884 ATP synthase A chain; Region: ATP-synt_A; cl00413 167555003885 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 167555003886 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 167555003887 LysE type translocator; Region: LysE; cl00565 167555003888 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 167555003889 ResB-like family; Region: ResB; pfam05140 167555003890 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555003891 Nitrogen regulatory protein P-II; Region: P-II; cl00412 167555003892 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 167555003893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555003894 RNA binding surface [nucleotide binding]; other site 167555003895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003896 adenylosuccinate lyase; Provisional; Region: PRK07380 167555003897 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 167555003898 tetramer interface [polypeptide binding]; other site 167555003899 active site 167555003900 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 167555003901 fumarate hydratase; Reviewed; Region: fumC; PRK00485 167555003902 Class II fumarases; Region: Fumarase_classII; cd01362 167555003903 active site 167555003904 tetramer interface [polypeptide binding]; other site 167555003905 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 167555003906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555003907 ATP binding site [chemical binding]; other site 167555003908 putative Mg++ binding site [ion binding]; other site 167555003909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555003910 nucleotide binding region [chemical binding]; other site 167555003911 ATP-binding site [chemical binding]; other site 167555003912 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 167555003913 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 167555003914 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555003915 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555003916 catalytic residue [active] 167555003917 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 167555003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003919 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974 167555003920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555003921 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167555003922 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 167555003923 inhibitor-cofactor binding pocket; inhibition site 167555003924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555003925 catalytic residue [active] 167555003926 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555003927 HSP70 interaction site [polypeptide binding]; other site 167555003928 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 167555003929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555003930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167555003931 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167555003932 active site 167555003933 catalytic tetrad [active] 167555003934 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 167555003935 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 167555003936 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167555003937 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 167555003938 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 167555003939 Sodium:solute symporter family; Region: SSF; cl00456 167555003940 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 167555003941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555003942 FeS/SAM binding site; other site 167555003943 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 167555003944 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167555003945 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 167555003946 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167555003947 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 167555003948 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167555003949 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 167555003950 DNA binding site [nucleotide binding] 167555003951 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 167555003952 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 167555003953 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 167555003954 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 167555003955 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167555003956 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 167555003957 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 167555003958 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167555003959 RPB1 interaction site [polypeptide binding]; other site 167555003960 RPB10 interaction site [polypeptide binding]; other site 167555003961 RPB11 interaction site [polypeptide binding]; other site 167555003962 RPB3 interaction site [polypeptide binding]; other site 167555003963 RPB12 interaction site [polypeptide binding]; other site 167555003964 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 167555003965 active site 167555003966 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 167555003967 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 167555003968 histidinol dehydrogenase; Region: hisD; TIGR00069 167555003969 NAD binding site [chemical binding]; other site 167555003970 dimerization interface [polypeptide binding]; other site 167555003971 product binding site; other site 167555003972 substrate binding site [chemical binding]; other site 167555003973 zinc binding site [ion binding]; other site 167555003974 catalytic residues [active] 167555003975 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 167555003976 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167555003977 active site 167555003978 dimer interface [polypeptide binding]; other site 167555003979 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 167555003980 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167555003981 protein binding site [polypeptide binding]; other site 167555003982 ribosome maturation protein RimP; Reviewed; Region: PRK00092 167555003983 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 167555003984 Sm1 motif; other site 167555003985 D3 - B interaction site; other site 167555003986 D1 - D2 interaction site; other site 167555003987 Hfq - Hfq interaction site; other site 167555003988 RNA binding pocket [nucleotide binding]; other site 167555003989 Sm2 motif; other site 167555003990 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 167555003991 NusA N-terminal domain; Region: NusA_N; pfam08529 167555003992 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 167555003993 RNA binding site [nucleotide binding]; other site 167555003994 homodimer interface [polypeptide binding]; other site 167555003995 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167555003996 G-X-X-G motif; other site 167555003997 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 167555003998 translation initiation factor IF-2; Validated; Region: infB; PRK05306 167555003999 large tegument protein UL36; Provisional; Region: PHA03247 167555004000 Single-stranded DNA binding protein, SSDP; Region: SSDP; pfam04503 167555004001 translation initiation factor IF-2; Validated; Region: infB; PRK05306 167555004002 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167555004003 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 167555004004 G1 box; other site 167555004005 putative GEF interaction site [polypeptide binding]; other site 167555004006 GTP/Mg2+ binding site [chemical binding]; other site 167555004007 Switch I region; other site 167555004008 G2 box; other site 167555004009 G3 box; other site 167555004010 Switch II region; other site 167555004011 G4 box; other site 167555004012 G5 box; other site 167555004013 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 167555004014 Translation-initiation factor 2; Region: IF-2; pfam11987 167555004015 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 167555004016 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 167555004017 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555004018 GTP cyclohydrolase I; Provisional; Region: PLN03044 167555004019 active site 167555004020 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 167555004021 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 167555004022 Protein of unknown function; Region: DUF3721; pfam12518 167555004023 GLTT repeat (6 copies); Region: GLTT; pfam01744 167555004024 GLTT repeat (6 copies); Region: GLTT; pfam01744 167555004025 Protein of unknown function; Region: DUF3721; pfam12518 167555004026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 167555004027 ABC-ATPase subunit interface; other site 167555004028 dimer interface [polypeptide binding]; other site 167555004029 putative PBP binding regions; other site 167555004030 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167555004031 metal binding site 2 [ion binding]; metal-binding site 167555004032 putative DNA binding helix; other site 167555004033 metal binding site 1 [ion binding]; metal-binding site 167555004034 dimer interface [polypeptide binding]; other site 167555004035 structural Zn2+ binding site [ion binding]; other site 167555004036 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167555004037 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 167555004038 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167555004039 intersubunit interface [polypeptide binding]; other site 167555004040 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167555004041 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 167555004042 P-loop, Walker A motif; other site 167555004043 Base recognition motif; other site 167555004044 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 167555004045 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 167555004046 structural tetrad; other site 167555004047 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 167555004048 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 167555004049 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 167555004050 Walker A/P-loop; other site 167555004051 ATP binding site [chemical binding]; other site 167555004052 Q-loop/lid; other site 167555004053 ABC transporter signature motif; other site 167555004054 Walker B; other site 167555004055 D-loop; other site 167555004056 H-loop/switch region; other site 167555004057 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 167555004058 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 167555004059 Walker A/P-loop; other site 167555004060 ATP binding site [chemical binding]; other site 167555004061 Q-loop/lid; other site 167555004062 ABC transporter signature motif; other site 167555004063 Walker B; other site 167555004064 D-loop; other site 167555004065 H-loop/switch region; other site 167555004066 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 167555004067 TM-ABC transporter signature motif; other site 167555004068 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 167555004069 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 167555004070 TM-ABC transporter signature motif; other site 167555004071 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 167555004072 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 167555004073 putative ligand binding site [chemical binding]; other site 167555004074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004075 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 167555004076 UreF; Region: UreF; pfam01730 167555004077 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 167555004078 dimer interface [polypeptide binding]; other site 167555004079 catalytic residues [active] 167555004080 UreD urease accessory protein; Region: UreD; cl00530 167555004081 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 167555004082 alpha-gamma subunit interface [polypeptide binding]; other site 167555004083 beta-gamma subunit interface [polypeptide binding]; other site 167555004084 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 167555004085 gamma-beta subunit interface [polypeptide binding]; other site 167555004086 alpha-beta subunit interface [polypeptide binding]; other site 167555004087 urease subunit alpha; Reviewed; Region: ureC; PRK13207 167555004088 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 167555004089 subunit interactions [polypeptide binding]; other site 167555004090 active site 167555004091 flap region; other site 167555004092 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 167555004093 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 167555004094 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 167555004095 RNA/DNA binding site [nucleotide binding]; other site 167555004096 RRM dimerization site [polypeptide binding]; other site 167555004097 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 167555004098 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 167555004099 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 167555004100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555004101 FeS/SAM binding site; other site 167555004102 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 167555004103 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 167555004104 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 167555004105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555004106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004107 homodimer interface [polypeptide binding]; other site 167555004108 catalytic residue [active] 167555004109 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 167555004110 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 167555004111 homodimer interface [polypeptide binding]; other site 167555004112 oligonucleotide binding site [chemical binding]; other site 167555004113 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 167555004114 RNA/DNA hybrid binding site [nucleotide binding]; other site 167555004115 active site 167555004116 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 167555004117 prephenate dehydratase; Provisional; Region: PRK11898 167555004118 Prephenate dehydratase; Region: PDT; pfam00800 167555004119 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 167555004120 putative L-Phe binding site [chemical binding]; other site 167555004121 tocopherol O-methyltransferase; Region: PLN02244 167555004122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555004123 S-adenosylmethionine binding site [chemical binding]; other site 167555004124 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 167555004125 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 167555004126 elongation factor Tu; Reviewed; Region: PRK00049 167555004127 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 167555004128 G1 box; other site 167555004129 GEF interaction site [polypeptide binding]; other site 167555004130 GTP/Mg2+ binding site [chemical binding]; other site 167555004131 Switch I region; other site 167555004132 G2 box; other site 167555004133 G3 box; other site 167555004134 Switch II region; other site 167555004135 G4 box; other site 167555004136 G5 box; other site 167555004137 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 167555004138 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 167555004139 Antibiotic Binding Site [chemical binding]; other site 167555004140 elongation factor G; Reviewed; Region: PRK00007 167555004141 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 167555004142 G1 box; other site 167555004143 putative GEF interaction site [polypeptide binding]; other site 167555004144 GTP/Mg2+ binding site [chemical binding]; other site 167555004145 Switch I region; other site 167555004146 G2 box; other site 167555004147 G3 box; other site 167555004148 Switch II region; other site 167555004149 G4 box; other site 167555004150 G5 box; other site 167555004151 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 167555004152 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 167555004153 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 167555004154 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 167555004155 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 167555004156 S17 interaction site [polypeptide binding]; other site 167555004157 S8 interaction site; other site 167555004158 16S rRNA interaction site [nucleotide binding]; other site 167555004159 streptomycin interaction site [chemical binding]; other site 167555004160 23S rRNA interaction site [nucleotide binding]; other site 167555004161 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 167555004162 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 167555004163 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 167555004164 active site 167555004165 dimer interface [polypeptide binding]; other site 167555004166 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 167555004167 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 167555004168 active site 167555004169 FMN binding site [chemical binding]; other site 167555004170 substrate binding site [chemical binding]; other site 167555004171 3Fe-4S cluster binding site [ion binding]; other site 167555004172 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 167555004173 domain interface; other site 167555004174 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 167555004175 lipoyl synthase; Provisional; Region: PRK05481 167555004176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555004177 FeS/SAM binding site; other site 167555004178 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 167555004179 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 167555004180 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 167555004181 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 167555004182 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 167555004183 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 167555004184 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 167555004185 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 167555004186 HEAT repeats; Region: HEAT_2; pfam13646 167555004187 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167555004188 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167555004189 Ligand binding site; other site 167555004190 Putative Catalytic site; other site 167555004191 DXD motif; other site 167555004192 NlpC/P60 family; Region: NLPC_P60; cl11438 167555004193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 167555004194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004195 binding surface 167555004196 TPR motif; other site 167555004197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004198 binding surface 167555004199 TPR motif; other site 167555004200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004201 binding surface 167555004202 TPR motif; other site 167555004203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555004204 S-adenosylmethionine binding site [chemical binding]; other site 167555004205 alanine racemase; Reviewed; Region: alr; PRK00053 167555004206 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 167555004207 active site 167555004208 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555004209 dimer interface [polypeptide binding]; other site 167555004210 substrate binding site [chemical binding]; other site 167555004211 catalytic residues [active] 167555004212 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167555004213 active site 167555004214 peptide chain release factor 1; Validated; Region: prfA; PRK00591 167555004215 RF-1 domain; Region: RF-1; cl02875 167555004216 RF-1 domain; Region: RF-1; cl02875 167555004217 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 167555004218 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 167555004219 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 167555004220 23S rRNA interface [nucleotide binding]; other site 167555004221 L3 interface [polypeptide binding]; other site 167555004222 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 167555004223 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 167555004224 dimerization interface 3.5A [polypeptide binding]; other site 167555004225 active site 167555004226 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 167555004227 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 167555004228 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 167555004229 alphaNTD homodimer interface [polypeptide binding]; other site 167555004230 alphaNTD - beta interaction site [polypeptide binding]; other site 167555004231 alphaNTD - beta' interaction site [polypeptide binding]; other site 167555004232 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 167555004233 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 167555004234 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 167555004235 adenylate kinase; Provisional; Region: PRK14531 167555004236 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 167555004237 AMP-binding site [chemical binding]; other site 167555004238 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 167555004239 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 167555004240 SecY translocase; Region: SecY; pfam00344 167555004241 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 167555004242 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 167555004243 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 167555004244 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 167555004245 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 167555004246 5S rRNA interface [nucleotide binding]; other site 167555004247 L27 interface [polypeptide binding]; other site 167555004248 23S rRNA interface [nucleotide binding]; other site 167555004249 L5 interface [polypeptide binding]; other site 167555004250 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 167555004251 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167555004252 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167555004253 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 167555004254 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 167555004255 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 167555004256 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 167555004257 KOW motif; Region: KOW; cl00354 167555004258 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 167555004259 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 167555004260 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 167555004261 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 167555004262 23S rRNA interface [nucleotide binding]; other site 167555004263 putative translocon interaction site; other site 167555004264 signal recognition particle (SRP54) interaction site; other site 167555004265 L23 interface [polypeptide binding]; other site 167555004266 trigger factor interaction site; other site 167555004267 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 167555004268 23S rRNA interface [nucleotide binding]; other site 167555004269 5S rRNA interface [nucleotide binding]; other site 167555004270 putative antibiotic binding site [chemical binding]; other site 167555004271 L25 interface [polypeptide binding]; other site 167555004272 L27 interface [polypeptide binding]; other site 167555004273 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 167555004274 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 167555004275 G-X-X-G motif; other site 167555004276 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 167555004277 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 167555004278 putative translocon binding site; other site 167555004279 protein-rRNA interface [nucleotide binding]; other site 167555004280 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 167555004281 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 167555004282 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 167555004283 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 167555004284 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 167555004285 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 167555004286 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 167555004287 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 167555004288 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 167555004289 4Fe-4S binding domain; Region: Fer4; cl02805 167555004290 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 167555004291 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167555004292 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 167555004293 protein RecA; Region: tigrfam_recA; TIGR02012 167555004294 hexamer interface [polypeptide binding]; other site 167555004295 Walker A motif; other site 167555004296 ATP binding site [chemical binding]; other site 167555004297 Walker B motif; other site 167555004298 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167555004299 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 167555004300 arogenate dehydrogenase; Reviewed; Region: PRK07417 167555004301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555004302 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 167555004303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555004304 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 167555004305 Domain of unknown function (DUF4308); Region: DUF4308; cl14566 167555004306 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 167555004307 MPN+ (JAMM) motif; other site 167555004308 Zinc-binding site [ion binding]; other site 167555004309 hypothetical protein; Validated; Region: PRK07411 167555004310 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 167555004311 ATP binding site [chemical binding]; other site 167555004312 substrate interface [chemical binding]; other site 167555004313 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 167555004314 active site residue [active] 167555004315 hypothetical protein; Validated; Region: PRK07413 167555004316 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167555004317 homodimer interface [polypeptide binding]; other site 167555004318 Walker A motif; other site 167555004319 ATP binding site [chemical binding]; other site 167555004320 hydroxycobalamin binding site [chemical binding]; other site 167555004321 Walker B motif; other site 167555004322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004323 Walker A motif; other site 167555004324 ATP binding site [chemical binding]; other site 167555004325 Walker B motif; other site 167555004326 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 167555004327 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 167555004328 Ligand Binding Site [chemical binding]; other site 167555004329 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 167555004330 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 167555004331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004332 Walker A/P-loop; other site 167555004333 ATP binding site [chemical binding]; other site 167555004334 Q-loop/lid; other site 167555004335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004336 ABC transporter signature motif; other site 167555004337 Walker B; other site 167555004338 D-loop; other site 167555004339 H-loop/switch region; other site 167555004340 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 167555004341 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 167555004342 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 167555004343 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 167555004344 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167555004345 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167555004346 PsaD; Region: PsaD; cl03639 167555004347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167555004348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555004349 dimer interface [polypeptide binding]; other site 167555004350 phosphorylation site [posttranslational modification] 167555004351 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 167555004352 Domain of unknown function DUF59; Region: DUF59; cl00941 167555004353 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 167555004354 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 167555004355 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 167555004356 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167555004357 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 167555004358 putative active site [active] 167555004359 catalytic site [active] 167555004360 putative substrate binding site [chemical binding]; other site 167555004361 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555004362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167555004363 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 167555004364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167555004365 active site 167555004366 catalytic tetrad [active] 167555004367 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 167555004368 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 167555004369 dimerization interface [polypeptide binding]; other site 167555004370 putative ATP binding site [chemical binding]; other site 167555004371 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 167555004372 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555004373 active site 167555004374 nucleotide binding site [chemical binding]; other site 167555004375 HIGH motif; other site 167555004376 KMSKS motif; other site 167555004377 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 167555004378 CMP-binding site; other site 167555004379 The sites determining sugar specificity; other site 167555004380 Low molecular weight phosphatase family; Region: LMWPc; cd00115 167555004381 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 167555004382 active site 167555004383 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 167555004384 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 167555004385 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 167555004386 heme binding pocket [chemical binding]; other site 167555004387 heme ligand [chemical binding]; other site 167555004388 isocitrate dehydrogenase; Validated; Region: PRK07362 167555004389 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167555004390 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 167555004391 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 167555004392 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 167555004393 phosphate binding site [ion binding]; other site 167555004394 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 167555004395 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 167555004396 active site 167555004397 catalytic residues [active] 167555004398 hydrolase; Region: PLN02578 167555004399 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 167555004400 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 167555004401 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 167555004402 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 167555004403 homodimer interface [polypeptide binding]; other site 167555004404 active site pocket [active] 167555004405 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 167555004406 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 167555004407 dimerization interface [polypeptide binding]; other site 167555004408 active site 167555004409 metal binding site [ion binding]; metal-binding site 167555004410 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 167555004411 dsRNA binding site [nucleotide binding]; other site 167555004412 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 167555004413 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 167555004414 RimM N-terminal domain; Region: RimM; pfam01782 167555004415 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 167555004416 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 167555004417 Substrate binding site; other site 167555004418 Cupin domain; Region: Cupin_2; cl09118 167555004419 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 167555004420 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 167555004421 glutaminase active site [active] 167555004422 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 167555004423 dimer interface [polypeptide binding]; other site 167555004424 active site 167555004425 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 167555004426 dimer interface [polypeptide binding]; other site 167555004427 active site 167555004428 photosystem I subunit VII; Region: psaC; CHL00065 167555004429 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167555004430 Phosphopantetheine attachment site; Region: PP-binding; cl09936 167555004431 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 167555004432 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 167555004433 dimer interface [polypeptide binding]; other site 167555004434 active site 167555004435 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167555004436 transketolase; Region: PLN02790 167555004437 TPP-binding site [chemical binding]; other site 167555004438 dimer interface [polypeptide binding]; other site 167555004439 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167555004440 PYR/PP interface [polypeptide binding]; other site 167555004441 dimer interface [polypeptide binding]; other site 167555004442 TPP binding site [chemical binding]; other site 167555004443 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167555004444 ThiC family; Region: ThiC; cl08031 167555004445 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 167555004446 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 167555004447 amidohydrolase; Region: amidohydrolases; TIGR01891 167555004448 metal binding site [ion binding]; metal-binding site 167555004449 dimer interface [polypeptide binding]; other site 167555004450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004451 binding surface 167555004452 TPR motif; other site 167555004453 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 167555004454 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 167555004455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555004456 Walker A motif; other site 167555004457 ATP binding site [chemical binding]; other site 167555004458 Walker B motif; other site 167555004459 arginine finger; other site 167555004460 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 167555004461 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 167555004462 SmpB-tmRNA interface; other site 167555004463 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 167555004464 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 167555004465 dimer interface [polypeptide binding]; other site 167555004466 putative anticodon binding site; other site 167555004467 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 167555004468 motif 1; other site 167555004469 active site 167555004470 motif 2; other site 167555004471 motif 3; other site 167555004472 Ycf27; Reviewed; Region: orf27; CHL00148 167555004473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555004474 active site 167555004475 phosphorylation site [posttranslational modification] 167555004476 intermolecular recognition site; other site 167555004477 dimerization interface [polypeptide binding]; other site 167555004478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555004479 DNA binding site [nucleotide binding] 167555004480 rod shape-determining protein MreC; Provisional; Region: PRK13922 167555004481 rod shape-determining protein MreC; Region: MreC; pfam04085 167555004482 rod shape-determining protein MreB; Provisional; Region: PRK13927 167555004483 Cell division protein FtsA; Region: FtsA; cl11496 167555004484 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167555004485 dimer interface [polypeptide binding]; other site 167555004486 ssDNA binding site [nucleotide binding]; other site 167555004487 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167555004488 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167555004489 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 167555004490 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 167555004491 oligomerization interface [polypeptide binding]; other site 167555004492 active site 167555004493 NAD+ binding site [chemical binding]; other site 167555004494 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 167555004495 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167555004496 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 167555004497 putative substrate binding site [chemical binding]; other site 167555004498 putative ATP binding site [chemical binding]; other site 167555004499 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 167555004500 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167555004501 minor groove reading motif; other site 167555004502 helix-hairpin-helix signature motif; other site 167555004503 substrate binding pocket [chemical binding]; other site 167555004504 active site 167555004505 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 167555004506 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 167555004507 active site 167555004508 8-oxo-dGMP binding site [chemical binding]; other site 167555004509 nudix motif; other site 167555004510 metal binding site [ion binding]; metal-binding site 167555004511 hydrolase, alpha/beta fold family protein; Region: PLN02824 167555004512 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555004513 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555004514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555004515 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555004516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 167555004517 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 167555004518 MgtE intracellular N domain; Region: MgtE_N; cl15244 167555004519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 167555004520 Divalent cation transporter; Region: MgtE; cl00786 167555004521 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 167555004522 catalytic residues [active] 167555004523 dimer interface [polypeptide binding]; other site 167555004524 CrcB-like protein; Region: CRCB; cl09114 167555004525 CrcB-like protein; Region: CRCB; cl09114 167555004526 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 167555004527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555004528 ATP binding site [chemical binding]; other site 167555004529 Mg2+ binding site [ion binding]; other site 167555004530 G-X-G motif; other site 167555004531 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 167555004532 anchoring element; other site 167555004533 dimer interface [polypeptide binding]; other site 167555004534 ATP binding site [chemical binding]; other site 167555004535 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 167555004536 active site 167555004537 putative metal-binding site [ion binding]; other site 167555004538 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 167555004539 IPP transferase; Region: IPPT; cl00403 167555004540 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 167555004541 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 167555004542 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 167555004543 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 167555004544 Predicted transcriptional regulators [Transcription]; Region: COG1725 167555004545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 167555004546 DNA-binding site [nucleotide binding]; DNA binding site 167555004547 serine O-acetyltransferase; Region: cysE; TIGR01172 167555004548 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 167555004549 trimer interface [polypeptide binding]; other site 167555004550 active site 167555004551 substrate binding site [chemical binding]; other site 167555004552 CoA binding site [chemical binding]; other site 167555004553 Dam-replacing family; Region: DRP; pfam06044 167555004554 ABC-2 type transporter; Region: ABC2_membrane; cl11417 167555004555 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 167555004556 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 167555004557 Walker A/P-loop; other site 167555004558 ATP binding site [chemical binding]; other site 167555004559 Q-loop/lid; other site 167555004560 ABC transporter signature motif; other site 167555004561 Walker B; other site 167555004562 D-loop; other site 167555004563 H-loop/switch region; other site 167555004564 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 167555004565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004566 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 167555004567 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 167555004568 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167555004569 NADP-binding site; other site 167555004570 homotetramer interface [polypeptide binding]; other site 167555004571 substrate binding site [chemical binding]; other site 167555004572 homodimer interface [polypeptide binding]; other site 167555004573 active site 167555004574 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 167555004575 active site 167555004576 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 167555004577 PPIC-type PPIASE domain; Region: Rotamase; cl08278 167555004578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 167555004579 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 167555004580 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 167555004581 putative active site [active] 167555004582 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 167555004583 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 167555004584 Walker A/P-loop; other site 167555004585 ATP binding site [chemical binding]; other site 167555004586 Q-loop/lid; other site 167555004587 ABC transporter signature motif; other site 167555004588 Walker B; other site 167555004589 D-loop; other site 167555004590 H-loop/switch region; other site 167555004591 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 167555004592 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 167555004593 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 167555004594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004595 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 167555004596 putative ADP-binding pocket [chemical binding]; other site 167555004597 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167555004598 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 167555004599 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167555004600 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167555004601 NADP-binding site; other site 167555004602 homotetramer interface [polypeptide binding]; other site 167555004603 substrate binding site [chemical binding]; other site 167555004604 homodimer interface [polypeptide binding]; other site 167555004605 active site 167555004606 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 167555004607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004609 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555004610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555004613 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 167555004614 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 167555004615 substrate binding site; other site 167555004616 tetramer interface; other site 167555004617 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 167555004618 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 167555004619 homopentamer interface [polypeptide binding]; other site 167555004620 active site 167555004621 YCF9; Region: Ycf9; cl09269 167555004622 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 167555004623 MutS domain I; Region: MutS_I; pfam01624 167555004624 MutS domain II; Region: MutS_II; pfam05188 167555004625 MutS family domain IV; Region: MutS_IV; pfam05190 167555004626 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 167555004627 Walker A/P-loop; other site 167555004628 ATP binding site [chemical binding]; other site 167555004629 Q-loop/lid; other site 167555004630 ABC transporter signature motif; other site 167555004631 Walker B; other site 167555004632 D-loop; other site 167555004633 H-loop/switch region; other site 167555004634 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 167555004635 Precorrin-8X methylmutase; Region: CbiC; pfam02570 167555004636 DNA polymerase III subunit delta; Validated; Region: PRK07452 167555004637 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 167555004638 aspartate kinase; Provisional; Region: PRK07431 167555004639 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 167555004640 putative nucleotide binding site [chemical binding]; other site 167555004641 putative catalytic residues [active] 167555004642 putative Mg ion binding site [ion binding]; other site 167555004643 putative aspartate binding site [chemical binding]; other site 167555004644 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167555004645 putative allosteric regulatory site; other site 167555004646 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167555004647 putative allosteric regulatory residue; other site 167555004648 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167555004649 putative allosteric regulatory site; other site 167555004650 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167555004651 excinuclease ABC subunit B; Provisional; Region: PRK05298 167555004652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555004653 ATP binding site [chemical binding]; other site 167555004654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555004655 nucleotide binding region [chemical binding]; other site 167555004656 ATP-binding site [chemical binding]; other site 167555004657 Ultra-violet resistance protein B; Region: UvrB; pfam12344 167555004658 UvrB/uvrC motif; Region: UVR; pfam02151 167555004659 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 167555004660 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 167555004661 Ligand Binding Site [chemical binding]; other site 167555004662 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 167555004663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167555004664 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 167555004665 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 167555004666 dihydrodipicolinate synthase; Region: dapA; TIGR00674 167555004667 dimer interface [polypeptide binding]; other site 167555004668 active site 167555004669 catalytic residue [active] 167555004670 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 167555004671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555004672 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 167555004673 trigger factor; Provisional; Region: tig; PRK01490 167555004674 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 167555004675 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 167555004676 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555004677 oligomer interface [polypeptide binding]; other site 167555004678 active site residues [active] 167555004679 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 167555004680 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 167555004681 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555004683 Walker A motif; other site 167555004684 ATP binding site [chemical binding]; other site 167555004685 Walker B motif; other site 167555004686 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 167555004687 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167555004688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555004689 Walker A motif; other site 167555004690 ATP binding site [chemical binding]; other site 167555004691 Walker B motif; other site 167555004692 arginine finger; other site 167555004693 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 167555004694 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 167555004695 DXD motif; other site 167555004696 Sporulation related domain; Region: SPOR; cl10051 167555004697 Stage II sporulation protein; Region: SpoIID; pfam08486 167555004698 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167555004699 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 167555004700 ribosomal protein L20; Region: rpl20; CHL00068 167555004701 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 167555004702 23S rRNA binding site [nucleotide binding]; other site 167555004703 L21 binding site [polypeptide binding]; other site 167555004704 L13 binding site [polypeptide binding]; other site 167555004705 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 167555004706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004707 binding surface 167555004708 TPR motif; other site 167555004709 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 167555004710 ThiS interaction site; other site 167555004711 putative active site [active] 167555004712 tetramer interface [polypeptide binding]; other site 167555004713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555004714 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555004715 NAD(P) binding site [chemical binding]; other site 167555004716 active site 167555004717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004718 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 167555004719 glycine dehydrogenase; Provisional; Region: PRK05367 167555004720 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167555004721 tetramer interface [polypeptide binding]; other site 167555004722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004723 catalytic residue [active] 167555004724 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167555004725 tetramer interface [polypeptide binding]; other site 167555004726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004727 catalytic residue [active] 167555004728 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 167555004729 lipoyl attachment site [posttranslational modification]; other site 167555004730 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 167555004731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555004732 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167555004733 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167555004734 Di-iron ligands [ion binding]; other site 167555004735 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167555004736 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 167555004737 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 167555004738 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 167555004739 replicative DNA helicase; Region: DnaB; TIGR00665 167555004740 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 167555004741 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 167555004742 Walker A motif; other site 167555004743 ATP binding site [chemical binding]; other site 167555004744 Walker B motif; other site 167555004745 DNA binding loops [nucleotide binding] 167555004746 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 167555004747 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 167555004748 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 167555004749 UTRA domain; Region: UTRA; cl01230 167555004750 SprT-like family; Region: SprT-like; pfam10263 167555004751 SprT homologues; Region: SprT; cl01182 167555004752 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 167555004753 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 167555004754 nucleotide binding pocket [chemical binding]; other site 167555004755 K-X-D-G motif; other site 167555004756 catalytic site [active] 167555004757 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 167555004758 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 167555004759 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 167555004760 Dimer interface [polypeptide binding]; other site 167555004761 BRCT sequence motif; other site 167555004762 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167555004763 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 167555004764 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555004765 active site 167555004766 HIGH motif; other site 167555004767 nucleotide binding site [chemical binding]; other site 167555004768 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 167555004769 active site 167555004770 KMSKS motif; other site 167555004771 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 167555004772 tRNA binding surface [nucleotide binding]; other site 167555004773 anticodon binding site; other site 167555004774 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 167555004775 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 167555004776 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167555004777 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 167555004778 spermidine synthase; Provisional; Region: PRK00811 167555004779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 167555004780 Arginase family; Region: Arginase; cl00306 167555004781 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 167555004782 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167555004783 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 167555004784 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 167555004785 dimer interface [polypeptide binding]; other site 167555004786 anticodon binding site; other site 167555004787 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 167555004788 homodimer interface [polypeptide binding]; other site 167555004789 motif 1; other site 167555004790 active site 167555004791 motif 2; other site 167555004792 GAD domain; Region: GAD; pfam02938 167555004793 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 167555004794 active site 167555004795 motif 3; other site 167555004796 CTP synthetase; Validated; Region: pyrG; PRK05380 167555004797 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 167555004798 Catalytic site [active] 167555004799 active site 167555004800 UTP binding site [chemical binding]; other site 167555004801 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 167555004802 active site 167555004803 putative oxyanion hole; other site 167555004804 catalytic triad [active] 167555004805 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 167555004806 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 167555004807 Ligand Binding Site [chemical binding]; other site 167555004808 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167555004809 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167555004810 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167555004811 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 167555004812 homodimer interface [polypeptide binding]; other site 167555004813 substrate-cofactor binding pocket; other site 167555004814 Aminotransferase class IV; Region: Aminotran_4; pfam01063 167555004815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004816 catalytic residue [active] 167555004817 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 167555004818 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167555004819 putative active site [active] 167555004820 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 167555004821 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555004822 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555004823 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 167555004824 hypothetical protein; Provisional; Region: PRK07394 167555004825 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167555004826 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 167555004827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167555004828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167555004829 putative substrate translocation pore; other site 167555004830 polyphosphate kinase; Provisional; Region: PRK05443 167555004831 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 167555004832 putative domain interface [polypeptide binding]; other site 167555004833 putative active site [active] 167555004834 catalytic site [active] 167555004835 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 167555004836 putative domain interface [polypeptide binding]; other site 167555004837 putative active site [active] 167555004838 catalytic site [active] 167555004839 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555004840 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555004841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555004842 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555004843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555004844 DNA binding residues [nucleotide binding] 167555004845 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 167555004846 NeuB family; Region: NeuB; cl00496 167555004847 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 167555004848 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 167555004849 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 167555004850 substrate binding site [chemical binding]; other site 167555004851 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 167555004852 substrate binding site [chemical binding]; other site 167555004853 ligand binding site [chemical binding]; other site 167555004854 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 167555004855 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 167555004856 Cl- selectivity filter; other site 167555004857 Cl- binding residues [ion binding]; other site 167555004858 pore gating glutamate residue; other site 167555004859 dimer interface [polypeptide binding]; other site 167555004860 H+/Cl- coupling transport residue; other site 167555004861 O-Antigen ligase; Region: Wzy_C; cl04850 167555004862 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 167555004863 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 167555004864 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 167555004865 putative active site [active] 167555004866 putative substrate binding site [chemical binding]; other site 167555004867 putative cosubstrate binding site; other site 167555004868 catalytic site [active] 167555004869 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 167555004870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555004871 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 167555004872 StbA protein; Region: StbA; pfam06406 167555004873 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 167555004874 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 167555004875 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 167555004876 shikimate binding site; other site 167555004877 NAD(P) binding site [chemical binding]; other site 167555004878 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 167555004879 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 167555004880 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 167555004881 ANP binding site [chemical binding]; other site 167555004882 Substrate Binding Site II [chemical binding]; other site 167555004883 Substrate Binding Site I [chemical binding]; other site 167555004884 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 167555004885 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 167555004886 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 167555004887 Mg++ binding site [ion binding]; other site 167555004888 putative catalytic motif [active] 167555004889 putative substrate binding site [chemical binding]; other site 167555004890 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 167555004891 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 167555004892 putative ADP-binding pocket [chemical binding]; other site 167555004893 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 167555004894 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 167555004895 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 167555004896 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 167555004897 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 167555004898 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 167555004899 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 167555004900 Walker A/P-loop; other site 167555004901 ATP binding site [chemical binding]; other site 167555004902 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 167555004903 ABC transporter signature motif; other site 167555004904 Walker B; other site 167555004905 D-loop; other site 167555004906 H-loop/switch region; other site 167555004907 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167555004908 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 167555004909 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167555004910 threonine synthase; Reviewed; Region: PRK06721 167555004911 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 167555004912 homodimer interface [polypeptide binding]; other site 167555004913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004914 catalytic residue [active]