-- dump date 20120504_155212 -- class Genbank::misc_feature -- table misc_feature_note -- id note 267747000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 267747000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747000003 Walker A motif; other site 267747000004 ATP binding site [chemical binding]; other site 267747000005 Walker B motif; other site 267747000006 arginine finger; other site 267747000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 267747000008 DnaA box-binding interface [nucleotide binding]; other site 267747000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 267747000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 267747000011 putative DNA binding surface [nucleotide binding]; other site 267747000012 dimer interface [polypeptide binding]; other site 267747000013 beta-clamp/clamp loader binding surface; other site 267747000014 beta-clamp/translesion DNA polymerase binding surface; other site 267747000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 267747000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 267747000017 Walker A/P-loop; other site 267747000018 ATP binding site [chemical binding]; other site 267747000019 Q-loop/lid; other site 267747000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000021 ABC transporter signature motif; other site 267747000022 Walker B; other site 267747000023 D-loop; other site 267747000024 H-loop/switch region; other site 267747000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 267747000026 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 267747000027 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 267747000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 267747000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267747000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 267747000031 anchoring element; other site 267747000032 dimer interface [polypeptide binding]; other site 267747000033 ATP binding site [chemical binding]; other site 267747000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 267747000035 active site 267747000036 putative metal-binding site [ion binding]; other site 267747000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 267747000038 DNA gyrase subunit A; Validated; Region: PRK05560 267747000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 267747000040 CAP-like domain; other site 267747000041 active site 267747000042 primary dimer interface [polypeptide binding]; other site 267747000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267747000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267747000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267747000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267747000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267747000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 267747000049 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 267747000050 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 267747000051 NAD binding site [chemical binding]; other site 267747000052 dimer interface [polypeptide binding]; other site 267747000053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267747000054 substrate binding site [chemical binding]; other site 267747000055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747000056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747000057 DNA binding site [nucleotide binding] 267747000058 domain linker motif; other site 267747000059 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 267747000060 dimerization interface [polypeptide binding]; other site 267747000061 putative ligand binding site [chemical binding]; other site 267747000062 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 267747000063 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 267747000064 Walker A/P-loop; other site 267747000065 ATP binding site [chemical binding]; other site 267747000066 Q-loop/lid; other site 267747000067 ABC transporter signature motif; other site 267747000068 Walker B; other site 267747000069 D-loop; other site 267747000070 H-loop/switch region; other site 267747000071 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 267747000072 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 267747000073 TM-ABC transporter signature motif; other site 267747000074 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 267747000075 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 267747000076 ligand binding site [chemical binding]; other site 267747000077 dimerization interface [polypeptide binding]; other site 267747000078 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267747000079 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 267747000080 substrate binding site [chemical binding]; other site 267747000081 dimer interface [polypeptide binding]; other site 267747000082 ATP binding site [chemical binding]; other site 267747000083 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 267747000084 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747000085 active site 267747000086 phosphorylation site [posttranslational modification] 267747000087 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 267747000088 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 267747000089 P-loop; other site 267747000090 active site 267747000091 phosphorylation site [posttranslational modification] 267747000092 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 267747000093 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 267747000094 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747000095 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 267747000096 Helix-turn-helix domains; Region: HTH; cl00088 267747000097 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747000098 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 267747000099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747000100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747000101 homodimer interface [polypeptide binding]; other site 267747000102 catalytic residue [active] 267747000103 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 267747000104 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747000105 SAF domain; Region: SAF; cl00555 267747000106 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 267747000107 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 267747000108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000109 Walker A motif; other site 267747000110 ATP binding site [chemical binding]; other site 267747000111 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 267747000112 putative peptidoglycan binding site; other site 267747000113 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 267747000114 putative peptidoglycan binding site; other site 267747000115 Bacterial transcriptional activator domain; Region: BTAD; smart01043 267747000116 H+ Antiporter protein; Region: 2A0121; TIGR00900 267747000117 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 267747000118 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 267747000119 Potassium binding sites [ion binding]; other site 267747000120 Cesium cation binding sites [ion binding]; other site 267747000121 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 267747000122 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 267747000123 FtsX-like permease family; Region: FtsX; pfam02687 267747000124 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747000125 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747000126 Walker A/P-loop; other site 267747000127 ATP binding site [chemical binding]; other site 267747000128 Q-loop/lid; other site 267747000129 ABC transporter signature motif; other site 267747000130 Walker B; other site 267747000131 D-loop; other site 267747000132 H-loop/switch region; other site 267747000133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267747000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747000135 active site 267747000136 phosphorylation site [posttranslational modification] 267747000137 intermolecular recognition site; other site 267747000138 dimerization interface [polypeptide binding]; other site 267747000139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267747000140 DNA binding residues [nucleotide binding] 267747000141 dimerization interface [polypeptide binding]; other site 267747000142 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 267747000143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747000144 dimer interface [polypeptide binding]; other site 267747000145 conserved gate region; other site 267747000146 putative PBP binding loops; other site 267747000147 ABC-ATPase subunit interface; other site 267747000148 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 267747000149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747000150 dimer interface [polypeptide binding]; other site 267747000151 conserved gate region; other site 267747000152 putative PBP binding loops; other site 267747000153 ABC-ATPase subunit interface; other site 267747000154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747000155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747000156 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 267747000157 Helix-turn-helix domains; Region: HTH; cl00088 267747000158 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747000159 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 267747000160 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 267747000161 NAD binding site [chemical binding]; other site 267747000162 sugar binding site [chemical binding]; other site 267747000163 divalent metal binding site [ion binding]; other site 267747000164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267747000165 dimer interface [polypeptide binding]; other site 267747000166 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 267747000167 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 267747000168 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 267747000169 Sulfatase; Region: Sulfatase; cl10460 267747000170 Sulfatase; Region: Sulfatase; cl10460 267747000171 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 267747000172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747000173 motif II; other site 267747000174 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 267747000175 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 267747000176 active site 267747000177 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267747000178 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 267747000179 substrate binding site [chemical binding]; other site 267747000180 ATP binding site [chemical binding]; other site 267747000181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267747000182 Histidine kinase; Region: HisKA_3; pfam07730 267747000183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747000184 ATP binding site [chemical binding]; other site 267747000185 Mg2+ binding site [ion binding]; other site 267747000186 G-X-G motif; other site 267747000187 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 267747000188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000189 NAD(P) binding site [chemical binding]; other site 267747000190 active site 267747000191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747000192 Helix-turn-helix domains; Region: HTH; cl00088 267747000193 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 267747000194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000195 Walker A/P-loop; other site 267747000196 ATP binding site [chemical binding]; other site 267747000197 Q-loop/lid; other site 267747000198 ABC transporter signature motif; other site 267747000199 Walker B; other site 267747000200 D-loop; other site 267747000201 H-loop/switch region; other site 267747000202 Predicted membrane protein [Function unknown]; Region: COG1511 267747000203 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 267747000204 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747000205 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747000206 Walker A/P-loop; other site 267747000207 ATP binding site [chemical binding]; other site 267747000208 Q-loop/lid; other site 267747000209 ABC transporter signature motif; other site 267747000210 Walker B; other site 267747000211 D-loop; other site 267747000212 H-loop/switch region; other site 267747000213 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 267747000214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747000215 S-adenosylmethionine binding site [chemical binding]; other site 267747000216 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 267747000217 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 267747000218 putative ligand binding residues [chemical binding]; other site 267747000219 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747000220 ABC-ATPase subunit interface; other site 267747000221 dimer interface [polypeptide binding]; other site 267747000222 putative PBP binding regions; other site 267747000223 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747000224 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747000225 Walker A/P-loop; other site 267747000226 ATP binding site [chemical binding]; other site 267747000227 Q-loop/lid; other site 267747000228 ABC transporter signature motif; other site 267747000229 Walker B; other site 267747000230 D-loop; other site 267747000231 H-loop/switch region; other site 267747000232 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 267747000233 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 267747000234 tetramerization interface [polypeptide binding]; other site 267747000235 NAD(P) binding site [chemical binding]; other site 267747000236 catalytic residues [active] 267747000237 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 267747000238 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 267747000239 putative ion selectivity filter; other site 267747000240 putative pore gating glutamate residue; other site 267747000241 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 267747000242 homodimer interface [polypeptide binding]; other site 267747000243 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 267747000244 active site pocket [active] 267747000245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 267747000246 DNA binding residues [nucleotide binding] 267747000247 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 267747000248 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 267747000249 Helix-turn-helix domains; Region: HTH; cl00088 267747000250 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747000251 fructokinase; Reviewed; Region: PRK09557 267747000252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747000253 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747000254 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 267747000255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747000256 dimer interface [polypeptide binding]; other site 267747000257 conserved gate region; other site 267747000258 putative PBP binding loops; other site 267747000259 ABC-ATPase subunit interface; other site 267747000260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747000261 dimer interface [polypeptide binding]; other site 267747000262 conserved gate region; other site 267747000263 putative PBP binding loops; other site 267747000264 ABC-ATPase subunit interface; other site 267747000265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747000266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747000267 DNA binding site [nucleotide binding] 267747000268 domain linker motif; other site 267747000269 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 267747000270 ligand binding site [chemical binding]; other site 267747000271 dimerization interface (open form) [polypeptide binding]; other site 267747000272 dimerization interface (closed form) [polypeptide binding]; other site 267747000273 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 267747000274 6-phosphofructokinase; Provisional; Region: PRK03202 267747000275 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 267747000276 active site 267747000277 ADP/pyrophosphate binding site [chemical binding]; other site 267747000278 dimerization interface [polypeptide binding]; other site 267747000279 allosteric effector site; other site 267747000280 fructose-1,6-bisphosphate binding site; other site 267747000281 Predicted transcriptional regulator [Transcription]; Region: COG2345 267747000282 Helix-turn-helix domains; Region: HTH; cl00088 267747000283 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 267747000284 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 267747000285 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 267747000286 Aspartase; Region: Aspartase; cd01357 267747000287 active sites [active] 267747000288 tetramer interface [polypeptide binding]; other site 267747000289 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 267747000290 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747000291 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 267747000292 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 267747000293 heme binding pocket [chemical binding]; other site 267747000294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267747000295 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747000296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000297 Walker A/P-loop; other site 267747000298 ATP binding site [chemical binding]; other site 267747000299 Q-loop/lid; other site 267747000300 ABC transporter signature motif; other site 267747000301 Walker B; other site 267747000302 D-loop; other site 267747000303 H-loop/switch region; other site 267747000304 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747000305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747000306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000307 ATP binding site [chemical binding]; other site 267747000308 Q-loop/lid; other site 267747000309 ABC transporter signature motif; other site 267747000310 Walker B; other site 267747000311 D-loop; other site 267747000312 H-loop/switch region; other site 267747000313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000314 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 267747000315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000316 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 267747000317 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 267747000318 metal ion-dependent adhesion site (MIDAS); other site 267747000319 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 267747000320 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 267747000321 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 267747000322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747000323 Radical SAM superfamily; Region: Radical_SAM; pfam04055 267747000324 FeS/SAM binding site; other site 267747000325 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 267747000326 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747000327 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747000328 Walker A/P-loop; other site 267747000329 ATP binding site [chemical binding]; other site 267747000330 Q-loop/lid; other site 267747000331 ABC transporter signature motif; other site 267747000332 Walker B; other site 267747000333 D-loop; other site 267747000334 H-loop/switch region; other site 267747000335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 267747000336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747000337 ABC-ATPase subunit interface; other site 267747000338 dimer interface [polypeptide binding]; other site 267747000339 putative PBP binding regions; other site 267747000340 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 267747000341 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 267747000342 putative ligand binding site [chemical binding]; other site 267747000343 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 267747000344 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 267747000345 putative ligand binding site [chemical binding]; other site 267747000346 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 267747000347 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 267747000348 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 267747000349 dimer interface [polypeptide binding]; other site 267747000350 substrate binding site [chemical binding]; other site 267747000351 ATP binding site [chemical binding]; other site 267747000352 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 267747000353 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 267747000354 thiamine phosphate binding site [chemical binding]; other site 267747000355 active site 267747000356 pyrophosphate binding site [ion binding]; other site 267747000357 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 267747000358 putative active site [active] 267747000359 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 267747000360 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 267747000361 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 267747000362 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747000363 K+-transporting ATPase, c chain; Region: KdpC; cl00944 267747000364 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 267747000365 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 267747000366 Ligand Binding Site [chemical binding]; other site 267747000367 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 267747000368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267747000369 dimer interface [polypeptide binding]; other site 267747000370 phosphorylation site [posttranslational modification] 267747000371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747000372 ATP binding site [chemical binding]; other site 267747000373 Mg2+ binding site [ion binding]; other site 267747000374 G-X-G motif; other site 267747000375 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 267747000376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747000377 active site 267747000378 phosphorylation site [posttranslational modification] 267747000379 intermolecular recognition site; other site 267747000380 dimerization interface [polypeptide binding]; other site 267747000381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267747000382 DNA binding site [nucleotide binding] 267747000383 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 267747000384 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 267747000385 Transglycosylase; Region: Transgly; cl07896 267747000386 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 267747000387 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747000388 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 267747000389 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; cl02342 267747000390 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 267747000391 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 267747000392 O-Antigen ligase; Region: Wzy_C; cl04850 267747000393 Chain length determinant protein; Region: Wzz; cl01623 267747000394 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 267747000395 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 267747000396 putative trimer interface [polypeptide binding]; other site 267747000397 putative active site [active] 267747000398 putative substrate binding site [chemical binding]; other site 267747000399 putative CoA binding site [chemical binding]; other site 267747000400 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267747000401 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267747000402 inhibitor-cofactor binding pocket; inhibition site 267747000403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747000404 catalytic residue [active] 267747000405 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267747000406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000407 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 267747000408 O-Antigen ligase; Region: Wzy_C; cl04850 267747000409 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 267747000410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 267747000411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 267747000412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 267747000414 classical (c) SDRs; Region: SDR_c; cd05233 267747000415 NAD(P) binding site [chemical binding]; other site 267747000416 active site 267747000417 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 267747000418 dimerization domain swap beta strand [polypeptide binding]; other site 267747000419 regulatory protein interface [polypeptide binding]; other site 267747000420 active site 267747000421 regulatory phosphorylation site [posttranslational modification]; other site 267747000422 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747000423 active site 267747000424 phosphorylation site [posttranslational modification] 267747000425 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 267747000426 P-loop; other site 267747000427 active site 267747000428 phosphorylation site [posttranslational modification] 267747000429 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747000430 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 267747000431 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 267747000432 putative substrate binding site [chemical binding]; other site 267747000433 putative ATP binding site [chemical binding]; other site 267747000434 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 267747000435 Helix-turn-helix domains; Region: HTH; cl00088 267747000436 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747000437 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 267747000438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000439 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 267747000440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000441 O-Antigen ligase; Region: Wzy_C; cl04850 267747000442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267747000443 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 267747000444 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 267747000445 active site 267747000446 homodimer interface [polypeptide binding]; other site 267747000447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267747000448 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 267747000449 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 267747000450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000452 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 267747000453 nudix motif; other site 267747000454 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 267747000455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747000456 ATP binding site [chemical binding]; other site 267747000457 putative Mg++ binding site [ion binding]; other site 267747000458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747000459 nucleotide binding region [chemical binding]; other site 267747000460 ATP-binding site [chemical binding]; other site 267747000461 Helicase associated domain (HA2); Region: HA2; cl04503 267747000462 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 267747000463 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 267747000464 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747000465 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 267747000466 Walker A/P-loop; other site 267747000467 ATP binding site [chemical binding]; other site 267747000468 Q-loop/lid; other site 267747000469 ABC transporter signature motif; other site 267747000470 Walker B; other site 267747000471 D-loop; other site 267747000472 H-loop/switch region; other site 267747000473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000474 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 267747000475 Walker A/P-loop; other site 267747000476 ATP binding site [chemical binding]; other site 267747000477 Q-loop/lid; other site 267747000478 ABC transporter signature motif; other site 267747000479 Walker B; other site 267747000480 D-loop; other site 267747000481 H-loop/switch region; other site 267747000482 Cobalt transport protein; Region: CbiQ; cl00463 267747000483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267747000484 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 267747000485 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 267747000486 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 267747000487 putative active site [active] 267747000488 putative FMN binding site [chemical binding]; other site 267747000489 putative substrate binding site [chemical binding]; other site 267747000490 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 267747000491 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 267747000492 dimer interface [polypeptide binding]; other site 267747000493 PYR/PP interface [polypeptide binding]; other site 267747000494 TPP binding site [chemical binding]; other site 267747000495 substrate binding site [chemical binding]; other site 267747000496 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 267747000497 Domain of unknown function; Region: EKR; cl11037 267747000498 4Fe-4S binding domain; Region: Fer4; cl02805 267747000499 4Fe-4S binding domain; Region: Fer4; cl02805 267747000500 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 267747000501 TPP-binding site [chemical binding]; other site 267747000502 dimer interface [polypeptide binding]; other site 267747000503 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 267747000504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000506 NAD(P) binding pocket [chemical binding]; other site 267747000507 4Fe-4S binding domain; Region: Fer4; cl02805 267747000508 Domain of unknown function DUF77; Region: DUF77; cl00307 267747000509 Transcriptional regulators [Transcription]; Region: FadR; COG2186 267747000510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747000511 DNA-binding site [nucleotide binding]; DNA binding site 267747000512 FCD domain; Region: FCD; cl11656 267747000513 glycolate transporter; Provisional; Region: PRK09695 267747000514 L-lactate permease; Region: Lactate_perm; cl00701 267747000515 Cysteine-rich domain; Region: CCG; pfam02754 267747000516 Cysteine-rich domain; Region: CCG; pfam02754 267747000517 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 267747000518 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 267747000519 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 267747000520 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 267747000521 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 267747000522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000523 Walker A/P-loop; other site 267747000524 ATP binding site [chemical binding]; other site 267747000525 Q-loop/lid; other site 267747000526 ABC transporter signature motif; other site 267747000527 Walker B; other site 267747000528 D-loop; other site 267747000529 H-loop/switch region; other site 267747000530 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 267747000531 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 267747000532 Walker A/P-loop; other site 267747000533 ATP binding site [chemical binding]; other site 267747000534 Q-loop/lid; other site 267747000535 ABC transporter signature motif; other site 267747000536 Walker B; other site 267747000537 D-loop; other site 267747000538 H-loop/switch region; other site 267747000539 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 267747000540 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747000541 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 267747000542 Walker A/P-loop; other site 267747000543 ATP binding site [chemical binding]; other site 267747000544 Q-loop/lid; other site 267747000545 ABC transporter signature motif; other site 267747000546 Walker B; other site 267747000547 D-loop; other site 267747000548 H-loop/switch region; other site 267747000549 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 267747000550 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 267747000551 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 267747000552 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 267747000553 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 267747000554 Amino acid permease; Region: AA_permease; cl00524 267747000555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267747000556 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747000557 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 267747000558 Walker A/P-loop; other site 267747000559 ATP binding site [chemical binding]; other site 267747000560 Q-loop/lid; other site 267747000561 ABC transporter signature motif; other site 267747000562 Walker B; other site 267747000563 D-loop; other site 267747000564 H-loop/switch region; other site 267747000565 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267747000566 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747000567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000568 Walker A/P-loop; other site 267747000569 ATP binding site [chemical binding]; other site 267747000570 Q-loop/lid; other site 267747000571 ABC transporter signature motif; other site 267747000572 Walker B; other site 267747000573 D-loop; other site 267747000574 H-loop/switch region; other site 267747000575 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 267747000576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267747000577 non-specific DNA binding site [nucleotide binding]; other site 267747000578 salt bridge; other site 267747000579 sequence-specific DNA binding site [nucleotide binding]; other site 267747000580 Domain of unknown function (DUF955); Region: DUF955; cl01076 267747000581 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 267747000582 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 267747000583 dimer interface [polypeptide binding]; other site 267747000584 putative anticodon binding site; other site 267747000585 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 267747000586 motif 1; other site 267747000587 dimer interface [polypeptide binding]; other site 267747000588 active site 267747000589 motif 2; other site 267747000590 motif 3; other site 267747000591 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 267747000592 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 267747000593 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267747000594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 267747000595 active site 267747000596 ATP binding site [chemical binding]; other site 267747000597 substrate binding site [chemical binding]; other site 267747000598 activation loop (A-loop); other site 267747000599 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 267747000600 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 267747000601 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 267747000602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747000603 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 267747000604 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 267747000605 active site 267747000606 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 267747000607 phosphopeptide binding site; other site 267747000608 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 267747000609 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 267747000610 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 267747000611 active site 267747000612 ATP binding site [chemical binding]; other site 267747000613 RHS Repeat; Region: RHS_repeat; cl11982 267747000614 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 267747000615 RHS Repeat; Region: RHS_repeat; cl11982 267747000616 RHS Repeat; Region: RHS_repeat; cl11982 267747000617 RHS Repeat; Region: RHS_repeat; cl11982 267747000618 RHS Repeat; Region: RHS_repeat; cl11982 267747000619 RHS Repeat; Region: RHS_repeat; cl11982 267747000620 RHS Repeat; Region: RHS_repeat; cl11982 267747000621 RHS Repeat; Region: RHS_repeat; cl11982 267747000622 RHS Repeat; Region: RHS_repeat; cl11982 267747000623 RHS Repeat; Region: RHS_repeat; cl11982 267747000624 RHS Repeat; Region: RHS_repeat; cl11982 267747000625 RHS Repeat; Region: RHS_repeat; cl11982 267747000626 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 267747000627 RHS Repeat; Region: RHS_repeat; cl11982 267747000628 RHS Repeat; Region: RHS_repeat; cl11982 267747000629 RHS Repeat; Region: RHS_repeat; cl11982 267747000630 RHS Repeat; Region: RHS_repeat; cl11982 267747000631 RHS Repeat; Region: RHS_repeat; cl11982 267747000632 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 267747000633 RHS Repeat; Region: RHS_repeat; cl11982 267747000634 RHS Repeat; Region: RHS_repeat; cl11982 267747000635 RHS Repeat; Region: RHS_repeat; cl11982 267747000636 RHS Repeat; Region: RHS_repeat; cl11982 267747000637 RHS Repeat; Region: RHS_repeat; cl11982 267747000638 RHS Repeat; Region: RHS_repeat; cl11982 267747000639 RHS Repeat; Region: RHS_repeat; cl11982 267747000640 RHS Repeat; Region: RHS_repeat; cl11982 267747000641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267747000642 RNA binding surface [nucleotide binding]; other site 267747000643 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 267747000644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747000645 Walker A motif; other site 267747000646 ATP binding site [chemical binding]; other site 267747000647 Walker B motif; other site 267747000648 arginine finger; other site 267747000649 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 267747000650 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 267747000651 recombination protein RecR; Reviewed; Region: recR; PRK00076 267747000652 RecR protein; Region: RecR; pfam02132 267747000653 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 267747000654 putative active site [active] 267747000655 putative metal-binding site [ion binding]; other site 267747000656 tetramer interface [polypeptide binding]; other site 267747000657 Helix-turn-helix domains; Region: HTH; cl00088 267747000658 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747000659 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747000660 Walker A/P-loop; other site 267747000661 ATP binding site [chemical binding]; other site 267747000662 Q-loop/lid; other site 267747000663 ABC transporter signature motif; other site 267747000664 Walker B; other site 267747000665 D-loop; other site 267747000666 H-loop/switch region; other site 267747000667 Uncharacterized conserved protein [Function unknown]; Region: COG2966 267747000668 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 267747000669 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 267747000670 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 267747000671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747000672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747000673 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 267747000674 active site 267747000675 motif I; other site 267747000676 motif II; other site 267747000677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747000678 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747000679 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 267747000680 Walker A/P-loop; other site 267747000681 ATP binding site [chemical binding]; other site 267747000682 Q-loop/lid; other site 267747000683 ABC transporter signature motif; other site 267747000684 Walker B; other site 267747000685 D-loop; other site 267747000686 H-loop/switch region; other site 267747000687 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 267747000688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747000689 active site 267747000690 HIGH motif; other site 267747000691 nucleotide binding site [chemical binding]; other site 267747000692 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 267747000693 active site 267747000694 KMSKS motif; other site 267747000695 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 267747000696 tRNA binding surface [nucleotide binding]; other site 267747000697 anticodon binding site; other site 267747000698 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 267747000699 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 267747000700 Amino acid permease; Region: AA_permease; cl00524 267747000701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000702 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 267747000703 Transcription factor WhiB; Region: Whib; pfam02467 267747000704 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 267747000705 homotrimer interaction site [polypeptide binding]; other site 267747000706 putative active site [active] 267747000707 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267747000708 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267747000709 ligand binding site [chemical binding]; other site 267747000710 flexible hinge region; other site 267747000711 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 267747000712 putative switch regulator; other site 267747000713 non-specific DNA interactions [nucleotide binding]; other site 267747000714 DNA binding site [nucleotide binding] 267747000715 sequence specific DNA binding site [nucleotide binding]; other site 267747000716 putative cAMP binding site [chemical binding]; other site 267747000717 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 267747000718 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 267747000719 minor groove reading motif; other site 267747000720 helix-hairpin-helix signature motif; other site 267747000721 substrate binding pocket [chemical binding]; other site 267747000722 active site 267747000723 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 267747000724 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 267747000725 catalytic residues [active] 267747000726 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 267747000727 putative active site [active] 267747000728 putative CoA binding site [chemical binding]; other site 267747000729 nudix motif; other site 267747000730 metal binding site [ion binding]; metal-binding site 267747000731 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 267747000732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747000733 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 267747000734 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 267747000735 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 267747000736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000737 Walker A motif; other site 267747000738 ATP binding site [chemical binding]; other site 267747000739 Walker B motif; other site 267747000740 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 267747000741 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 267747000742 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 267747000743 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 267747000744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747000745 ATP binding site [chemical binding]; other site 267747000746 putative Mg++ binding site [ion binding]; other site 267747000747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747000748 nucleotide binding region [chemical binding]; other site 267747000749 ATP-binding site [chemical binding]; other site 267747000750 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 267747000751 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 267747000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747000753 S-adenosylmethionine binding site [chemical binding]; other site 267747000754 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 267747000755 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 267747000756 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 267747000757 active site 267747000758 interdomain interaction site; other site 267747000759 putative metal-binding site [ion binding]; other site 267747000760 nucleotide binding site [chemical binding]; other site 267747000761 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 267747000762 domain I; other site 267747000763 DNA binding groove [nucleotide binding] 267747000764 phosphate binding site [ion binding]; other site 267747000765 domain II; other site 267747000766 domain III; other site 267747000767 nucleotide binding site [chemical binding]; other site 267747000768 catalytic site [active] 267747000769 domain IV; other site 267747000770 thymidylate kinase; Validated; Region: tmk; PRK00698 267747000771 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 267747000772 TMP-binding site; other site 267747000773 ATP-binding site [chemical binding]; other site 267747000774 DNA polymerase III subunit delta'; Validated; Region: PRK07940 267747000775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747000776 Walker A motif; other site 267747000777 ATP binding site [chemical binding]; other site 267747000778 Walker B motif; other site 267747000779 arginine finger; other site 267747000780 DoxX; Region: DoxX; cl00976 267747000781 PSP1 C-terminal conserved region; Region: PSP1; cl00770 267747000782 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 267747000783 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747000784 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 267747000785 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 267747000786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000788 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 267747000789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747000790 catalytic core [active] 267747000791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000792 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 267747000793 dimer interface [polypeptide binding]; other site 267747000794 substrate binding site [chemical binding]; other site 267747000795 metal binding sites [ion binding]; metal-binding site 267747000796 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 267747000797 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 267747000798 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 267747000799 Ligand Binding Site [chemical binding]; other site 267747000800 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747000801 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 267747000802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747000803 Walker A motif; other site 267747000804 ATP binding site [chemical binding]; other site 267747000805 Walker B motif; other site 267747000806 arginine finger; other site 267747000807 Peptidase family M41; Region: Peptidase_M41; pfam01434 267747000808 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 267747000809 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 267747000810 homodecamer interface [polypeptide binding]; other site 267747000811 GTP cyclohydrolase I; Provisional; Region: PLN03044 267747000812 active site 267747000813 putative catalytic site residues [active] 267747000814 zinc binding site [ion binding]; other site 267747000815 GTP-CH-I/GFRP interaction surface; other site 267747000816 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267747000817 ligand binding site [chemical binding]; other site 267747000818 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 267747000819 dihydropteroate synthase; Region: DHPS; TIGR01496 267747000820 substrate binding pocket [chemical binding]; other site 267747000821 dimer interface [polypeptide binding]; other site 267747000822 inhibitor binding site; inhibition site 267747000823 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 267747000824 homooctamer interface [polypeptide binding]; other site 267747000825 active site 267747000826 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 267747000827 catalytic center binding site [active] 267747000828 ATP binding site [chemical binding]; other site 267747000829 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 267747000830 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 267747000831 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 267747000832 Lsr2; Region: Lsr2; pfam11774 267747000833 Clp protease ATP binding subunit; Region: clpC; CHL00095 267747000834 Clp amino terminal domain; Region: Clp_N; pfam02861 267747000835 Clp amino terminal domain; Region: Clp_N; pfam02861 267747000836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747000837 Walker A motif; other site 267747000838 ATP binding site [chemical binding]; other site 267747000839 Walker B motif; other site 267747000840 arginine finger; other site 267747000841 UvrB/uvrC motif; Region: UVR; pfam02151 267747000842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747000843 Walker A motif; other site 267747000844 ATP binding site [chemical binding]; other site 267747000845 Walker B motif; other site 267747000846 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 267747000847 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 267747000848 Protein of unknown function (DUF979); Region: DUF979; cl01572 267747000849 Protein of unknown function (DUF969); Region: DUF969; cl01573 267747000850 LamB/YcsF family; Region: LamB_YcsF; cl00664 267747000851 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 267747000852 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 267747000853 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 267747000854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747000855 putative substrate translocation pore; other site 267747000856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747000857 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 267747000858 TIGR01777 family protein; Region: yfcH 267747000859 putative NAD(P) binding site [chemical binding]; other site 267747000860 putative active site [active] 267747000861 Rhomboid family; Region: Rhomboid; cl11446 267747000862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267747000864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747000865 active site 267747000866 phosphorylation site [posttranslational modification] 267747000867 intermolecular recognition site; other site 267747000868 dimerization interface [polypeptide binding]; other site 267747000869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267747000870 DNA binding residues [nucleotide binding] 267747000871 dimerization interface [polypeptide binding]; other site 267747000872 Histidine kinase; Region: HisKA_3; pfam07730 267747000873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267747000874 CAT RNA binding domain; Region: CAT_RBD; cl03904 267747000875 transcriptional antiterminator BglG; Provisional; Region: PRK09772 267747000876 PRD domain; Region: PRD; cl15445 267747000877 PRD domain; Region: PRD; cl15445 267747000878 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 267747000879 HPr interaction site; other site 267747000880 glycerol kinase (GK) interaction site [polypeptide binding]; other site 267747000881 active site 267747000882 phosphorylation site [posttranslational modification] 267747000883 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 267747000884 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747000885 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 267747000886 active site turn [active] 267747000887 phosphorylation site [posttranslational modification] 267747000888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747000889 D-galactonate transporter; Region: 2A0114; TIGR00893 267747000890 putative substrate translocation pore; other site 267747000891 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 267747000892 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 267747000893 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 267747000894 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 267747000895 Helix-turn-helix domains; Region: HTH; cl00088 267747000896 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747000897 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 267747000898 endonuclease III; Region: ENDO3c; smart00478 267747000899 minor groove reading motif; other site 267747000900 helix-hairpin-helix signature motif; other site 267747000901 substrate binding pocket [chemical binding]; other site 267747000902 active site 267747000903 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 267747000904 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 267747000905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 267747000906 inhibitor-cofactor binding pocket; inhibition site 267747000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747000908 catalytic residue [active] 267747000909 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 267747000910 dimer interface [polypeptide binding]; other site 267747000911 active site 267747000912 Schiff base residues; other site 267747000913 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 267747000914 active site 267747000915 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 267747000916 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 267747000917 domain interfaces; other site 267747000918 active site 267747000919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000920 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 267747000921 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 267747000922 substrate binding site [chemical binding]; other site 267747000923 active site 267747000924 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 267747000925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000926 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 267747000927 ferrochelatase; Reviewed; Region: hemH; PRK00035 267747000928 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 267747000929 C-terminal domain interface [polypeptide binding]; other site 267747000930 active site 267747000931 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 267747000932 active site 267747000933 N-terminal domain interface [polypeptide binding]; other site 267747000934 Chlorite dismutase; Region: Chlor_dismutase; cl01280 267747000935 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 267747000936 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 267747000937 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 267747000938 DNA repair protein RadA; Provisional; Region: PRK11823 267747000939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747000940 Walker A motif; other site 267747000941 ATP binding site [chemical binding]; other site 267747000942 Walker B motif; other site 267747000943 malate dehydrogenase; Provisional; Region: PRK13529 267747000944 Malic enzyme, N-terminal domain; Region: malic; pfam00390 267747000945 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 267747000946 NAD(P) binding site [chemical binding]; other site 267747000947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 267747000948 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 267747000949 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 267747000950 AP (apurinic/apyrimidinic) site pocket; other site 267747000951 Metal-binding active site; metal-binding site 267747000952 Proline dehydrogenase; Region: Pro_dh; cl03282 267747000953 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 267747000954 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 267747000955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000956 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 267747000957 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 267747000958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000959 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 267747000960 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747000961 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 267747000962 active site 267747000963 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 267747000964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747000965 catalytic core [active] 267747000966 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 267747000967 catalytic residues [active] 267747000968 LysE type translocator; Region: LysE; cl00565 267747000969 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 267747000970 ResB-like family; Region: ResB; pfam05140 267747000971 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 267747000972 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 267747000973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 267747000974 Sporulation and spore germination; Region: Germane; cl11253 267747000975 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 267747000976 classical (c) SDRs; Region: SDR_c; cd05233 267747000977 NAD(P) binding site [chemical binding]; other site 267747000978 active site 267747000979 mycothione reductase; Reviewed; Region: PRK07846 267747000980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747000981 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267747000982 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747000983 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 267747000984 intersubunit interface [polypeptide binding]; other site 267747000985 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747000986 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747000987 Walker A/P-loop; other site 267747000988 ATP binding site [chemical binding]; other site 267747000989 Q-loop/lid; other site 267747000990 ABC transporter signature motif; other site 267747000991 Walker B; other site 267747000992 D-loop; other site 267747000993 H-loop/switch region; other site 267747000994 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747000995 ABC-ATPase subunit interface; other site 267747000996 dimer interface [polypeptide binding]; other site 267747000997 putative PBP binding regions; other site 267747000998 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 267747000999 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 267747001000 FAD binding pocket [chemical binding]; other site 267747001001 FAD binding motif [chemical binding]; other site 267747001002 phosphate binding motif [ion binding]; other site 267747001003 NAD binding pocket [chemical binding]; other site 267747001004 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 267747001005 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 267747001006 Walker A/P-loop; other site 267747001007 ATP binding site [chemical binding]; other site 267747001008 Q-loop/lid; other site 267747001009 ABC transporter signature motif; other site 267747001010 Walker B; other site 267747001011 D-loop; other site 267747001012 H-loop/switch region; other site 267747001013 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 267747001014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001015 dimer interface [polypeptide binding]; other site 267747001016 conserved gate region; other site 267747001017 putative PBP binding loops; other site 267747001018 ABC-ATPase subunit interface; other site 267747001019 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 267747001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001021 dimer interface [polypeptide binding]; other site 267747001022 conserved gate region; other site 267747001023 putative PBP binding loops; other site 267747001024 ABC-ATPase subunit interface; other site 267747001025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747001026 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 267747001027 active site 267747001028 Ap6A binding site [chemical binding]; other site 267747001029 nudix motif; other site 267747001030 metal binding site [ion binding]; metal-binding site 267747001031 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747001032 catalytic core [active] 267747001033 polyphosphate kinase; Provisional; Region: PRK05443 267747001034 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 267747001035 putative domain interface [polypeptide binding]; other site 267747001036 putative active site [active] 267747001037 catalytic site [active] 267747001038 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 267747001039 putative domain interface [polypeptide binding]; other site 267747001040 putative active site [active] 267747001041 catalytic site [active] 267747001042 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267747001043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267747001044 DNA binding site [nucleotide binding] 267747001045 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 267747001046 putative active site [active] 267747001047 dimerization interface [polypeptide binding]; other site 267747001048 putative tRNAtyr binding site [nucleotide binding]; other site 267747001049 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 267747001050 heme-binding site [chemical binding]; other site 267747001051 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 267747001052 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 267747001053 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 267747001054 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 267747001055 Bacterial sugar transferase; Region: Bac_transf; cl00939 267747001056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001057 NAD(P) binding site [chemical binding]; other site 267747001058 active site 267747001059 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 267747001060 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 267747001061 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 267747001062 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 267747001063 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 267747001064 dimerization domain swap beta strand [polypeptide binding]; other site 267747001065 regulatory protein interface [polypeptide binding]; other site 267747001066 active site 267747001067 regulatory phosphorylation site [posttranslational modification]; other site 267747001068 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 267747001069 substrate binding site; other site 267747001070 dimer interface; other site 267747001071 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 267747001072 homotrimer interaction site [polypeptide binding]; other site 267747001073 zinc binding site [ion binding]; other site 267747001074 CDP-binding sites; other site 267747001075 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 267747001076 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 267747001077 P-loop; other site 267747001078 active site 267747001079 phosphorylation site [posttranslational modification] 267747001080 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 267747001081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267747001082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747001083 active site 267747001084 phosphorylation site [posttranslational modification] 267747001085 intermolecular recognition site; other site 267747001086 dimerization interface [polypeptide binding]; other site 267747001087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267747001088 DNA binding site [nucleotide binding] 267747001089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267747001090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267747001091 dimer interface [polypeptide binding]; other site 267747001092 phosphorylation site [posttranslational modification] 267747001093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747001094 ATP binding site [chemical binding]; other site 267747001095 Mg2+ binding site [ion binding]; other site 267747001096 G-X-G motif; other site 267747001097 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 267747001098 PhoU domain; Region: PhoU; pfam01895 267747001099 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 267747001100 NodB motif; other site 267747001101 active site 267747001102 catalytic site [active] 267747001103 Zn binding site [ion binding]; other site 267747001104 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747001105 catalytic core [active] 267747001106 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 267747001107 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747001108 active site 267747001109 phosphorylation site [posttranslational modification] 267747001110 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 267747001111 P-loop; other site 267747001112 active site 267747001113 phosphorylation site [posttranslational modification] 267747001114 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 267747001115 active site 267747001116 homodimer interface [polypeptide binding]; other site 267747001117 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747001118 Amino acid permease; Region: AA_permease; cl00524 267747001119 serine hydroxymethyltransferase; Provisional; Region: PRK13580 267747001120 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 267747001121 dimer interface [polypeptide binding]; other site 267747001122 glycine-pyridoxal phosphate binding site [chemical binding]; other site 267747001123 active site 267747001124 folate binding site [chemical binding]; other site 267747001125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267747001126 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 267747001127 substrate binding site [chemical binding]; other site 267747001128 ATP binding site [chemical binding]; other site 267747001129 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 267747001130 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 267747001131 active site 267747001132 intersubunit interface [polypeptide binding]; other site 267747001133 catalytic residue [active] 267747001134 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 267747001135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001136 NAD(P) binding site [chemical binding]; other site 267747001137 active site 267747001138 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 267747001139 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 267747001140 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 267747001141 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 267747001142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267747001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001144 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 267747001145 substrate binding site [chemical binding]; other site 267747001146 catalytic residues [active] 267747001147 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 267747001148 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 267747001149 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 267747001150 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 267747001151 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 267747001152 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 267747001153 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747001154 active site 267747001155 HIGH motif; other site 267747001156 nucleotide binding site [chemical binding]; other site 267747001157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 267747001158 KMSKS motif; other site 267747001159 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 267747001160 tRNA binding surface [nucleotide binding]; other site 267747001161 anticodon binding site; other site 267747001162 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 267747001163 Protein of unknown function (DUF322); Region: DUF322; cl00574 267747001164 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 267747001165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267747001166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267747001167 DNA binding residues [nucleotide binding] 267747001168 Protein of unknown function (DUF322); Region: DUF322; cl00574 267747001169 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 267747001170 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 267747001171 Walker A/P-loop; other site 267747001172 ATP binding site [chemical binding]; other site 267747001173 Q-loop/lid; other site 267747001174 ABC transporter signature motif; other site 267747001175 Walker B; other site 267747001176 D-loop; other site 267747001177 H-loop/switch region; other site 267747001178 TOBE domain; Region: TOBE_2; cl01440 267747001179 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 267747001180 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 267747001181 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 267747001182 Helix-turn-helix domains; Region: HTH; cl00088 267747001183 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 267747001184 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747001185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267747001186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001187 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 267747001188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747001189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001191 dimer interface [polypeptide binding]; other site 267747001192 conserved gate region; other site 267747001193 putative PBP binding loops; other site 267747001194 ABC-ATPase subunit interface; other site 267747001195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001196 dimer interface [polypeptide binding]; other site 267747001197 conserved gate region; other site 267747001198 ABC-ATPase subunit interface; other site 267747001199 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 267747001200 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 267747001201 NAD(P) binding site [chemical binding]; other site 267747001202 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 267747001203 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 267747001204 substrate-cofactor binding pocket; other site 267747001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747001206 catalytic residue [active] 267747001207 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 267747001208 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 267747001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747001210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747001211 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 267747001212 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 267747001213 Walker A/P-loop; other site 267747001214 ATP binding site [chemical binding]; other site 267747001215 Q-loop/lid; other site 267747001216 ABC transporter signature motif; other site 267747001217 Walker B; other site 267747001218 D-loop; other site 267747001219 H-loop/switch region; other site 267747001220 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 267747001221 Protein of unknown function, DUF488; Region: DUF488; cl01246 267747001222 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 267747001223 putative ADP-ribose binding site [chemical binding]; other site 267747001224 putative active site [active] 267747001225 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 267747001226 Prostaglandin dehydrogenases; Region: PGDH; cd05288 267747001227 NAD(P) binding site [chemical binding]; other site 267747001228 substrate binding site [chemical binding]; other site 267747001229 dimer interface [polypeptide binding]; other site 267747001230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267747001231 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 267747001232 Walker A/P-loop; other site 267747001233 ATP binding site [chemical binding]; other site 267747001234 Q-loop/lid; other site 267747001235 ABC transporter signature motif; other site 267747001236 Walker B; other site 267747001237 D-loop; other site 267747001238 H-loop/switch region; other site 267747001239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267747001240 Histidine kinase; Region: HisKA_3; pfam07730 267747001241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267747001242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747001243 active site 267747001244 phosphorylation site [posttranslational modification] 267747001245 intermolecular recognition site; other site 267747001246 dimerization interface [polypeptide binding]; other site 267747001247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267747001248 DNA binding residues [nucleotide binding] 267747001249 dimerization interface [polypeptide binding]; other site 267747001250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747001251 catalytic core [active] 267747001252 CobD/Cbib protein; Region: CobD_Cbib; cl00561 267747001253 cobyric acid synthase; Provisional; Region: PRK00784 267747001254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747001255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747001256 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 267747001257 catalytic triad [active] 267747001258 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747001259 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747001260 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747001261 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 267747001262 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 267747001263 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 267747001264 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 267747001265 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747001266 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 267747001267 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 267747001268 putative active site [active] 267747001269 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 267747001270 putative active site [active] 267747001271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 267747001273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747001274 putative PBP binding regions; other site 267747001275 ABC-ATPase subunit interface; other site 267747001276 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747001277 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747001278 Walker A/P-loop; other site 267747001279 ATP binding site [chemical binding]; other site 267747001280 Q-loop/lid; other site 267747001281 ABC transporter signature motif; other site 267747001282 Walker B; other site 267747001283 D-loop; other site 267747001284 H-loop/switch region; other site 267747001285 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 267747001286 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 267747001287 putative ligand binding residues [chemical binding]; other site 267747001288 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 267747001289 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 267747001290 Precorrin-8X methylmutase; Region: CbiC; pfam02570 267747001291 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 267747001292 Cobalt transport protein component CbiN; Region: CbiN; cl00842 267747001293 Cobalt transport protein; Region: CbiQ; cl00463 267747001294 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 267747001295 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 267747001296 Walker A/P-loop; other site 267747001297 ATP binding site [chemical binding]; other site 267747001298 Q-loop/lid; other site 267747001299 ABC transporter signature motif; other site 267747001300 Walker B; other site 267747001301 D-loop; other site 267747001302 H-loop/switch region; other site 267747001303 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 267747001304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747001305 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 267747001306 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 267747001307 homodimer interface [polypeptide binding]; other site 267747001308 Walker A motif; other site 267747001309 ATP binding site [chemical binding]; other site 267747001310 hydroxycobalamin binding site [chemical binding]; other site 267747001311 Walker B motif; other site 267747001312 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 267747001313 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 267747001314 catalytic triad [active] 267747001315 hypothetical protein; Provisional; Region: PRK07908 267747001316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747001317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747001318 homodimer interface [polypeptide binding]; other site 267747001319 catalytic residue [active] 267747001320 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747001321 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 267747001322 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 267747001323 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 267747001324 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 267747001325 putative dimer interface [polypeptide binding]; other site 267747001326 active site pocket [active] 267747001327 putative cataytic base [active] 267747001328 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 267747001329 homotrimer interface [polypeptide binding]; other site 267747001330 Walker A motif; other site 267747001331 GTP binding site [chemical binding]; other site 267747001332 Walker B motif; other site 267747001333 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 267747001334 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747001335 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 267747001336 intersubunit interface [polypeptide binding]; other site 267747001337 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 267747001338 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747001339 active site 267747001340 phosphorylation site [posttranslational modification] 267747001341 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 267747001342 P-loop; other site 267747001343 active site 267747001344 phosphorylation site [posttranslational modification] 267747001345 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 267747001346 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 267747001347 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 267747001348 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 267747001349 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 267747001350 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 267747001351 ring oligomerisation interface [polypeptide binding]; other site 267747001352 ATP/Mg binding site [chemical binding]; other site 267747001353 stacking interactions; other site 267747001354 hinge regions; other site 267747001355 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 267747001356 catalytic residue [active] 267747001357 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 267747001358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747001359 DNA-binding site [nucleotide binding]; DNA binding site 267747001360 UTRA domain; Region: UTRA; cl01230 267747001361 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267747001362 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 267747001363 substrate binding site [chemical binding]; other site 267747001364 ATP binding site [chemical binding]; other site 267747001365 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 267747001366 KduI/IolB family; Region: KduI; cl01508 267747001367 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 267747001368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 267747001369 PYR/PP interface [polypeptide binding]; other site 267747001370 dimer interface [polypeptide binding]; other site 267747001371 TPP binding site [chemical binding]; other site 267747001372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 267747001373 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 267747001374 TPP-binding site; other site 267747001375 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 267747001376 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 267747001377 tetrameric interface [polypeptide binding]; other site 267747001378 NAD binding site [chemical binding]; other site 267747001379 catalytic residues [active] 267747001380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747001381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747001382 DNA binding site [nucleotide binding] 267747001383 domain linker motif; other site 267747001384 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 267747001385 dimerization interface [polypeptide binding]; other site 267747001386 ligand binding site [chemical binding]; other site 267747001387 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267747001388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001389 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 267747001390 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 267747001391 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 267747001392 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 267747001393 AP (apurinic/apyrimidinic) site pocket; other site 267747001394 DNA interaction; other site 267747001395 Metal-binding active site; metal-binding site 267747001396 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267747001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001398 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 267747001399 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 267747001400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001401 putative substrate translocation pore; other site 267747001402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001403 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 267747001404 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 267747001405 DNA interaction; other site 267747001406 Metal-binding active site; metal-binding site 267747001407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267747001408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001409 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 267747001410 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 267747001411 CutC family; Region: CutC; cl01218 267747001412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747001413 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 267747001414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747001415 ATP binding site [chemical binding]; other site 267747001416 putative Mg++ binding site [ion binding]; other site 267747001417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747001418 nucleotide binding region [chemical binding]; other site 267747001419 ATP-binding site [chemical binding]; other site 267747001420 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 267747001421 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 267747001422 active site 267747001423 trimer interface [polypeptide binding]; other site 267747001424 allosteric site; other site 267747001425 active site lid [active] 267747001426 hexamer (dimer of trimers) interface [polypeptide binding]; other site 267747001427 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 267747001428 DNA-binding site [nucleotide binding]; DNA binding site 267747001429 RNA-binding motif; other site 267747001430 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 267747001431 Permease family; Region: Xan_ur_permease; cl00967 267747001432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267747001433 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 267747001434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267747001435 catalytic residue [active] 267747001436 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 267747001437 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 267747001438 active site 267747001439 dimer interface [polypeptide binding]; other site 267747001440 Helix-turn-helix domains; Region: HTH; cl00088 267747001441 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 267747001442 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 267747001443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 267747001444 catalytic residues [active] 267747001445 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 267747001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001447 putative substrate translocation pore; other site 267747001448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001449 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 267747001450 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 267747001451 active site 267747001452 substrate binding site; other site 267747001453 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 267747001454 SAF domain; Region: SAF; cl00555 267747001455 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 267747001456 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 267747001457 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 267747001458 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 267747001459 dimer interface [polypeptide binding]; other site 267747001460 putative functional site; other site 267747001461 putative MPT binding site; other site 267747001462 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 267747001463 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747001464 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 267747001465 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 267747001466 trimer interface [polypeptide binding]; other site 267747001467 dimer interface [polypeptide binding]; other site 267747001468 putative active site [active] 267747001469 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 267747001470 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 267747001471 dimer interface [polypeptide binding]; other site 267747001472 putative functional site; other site 267747001473 putative MPT binding site; other site 267747001474 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 267747001475 MoaE homodimer interface [polypeptide binding]; other site 267747001476 MoaD interaction [polypeptide binding]; other site 267747001477 active site residues [active] 267747001478 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 267747001479 MoaE interaction surface [polypeptide binding]; other site 267747001480 MoeB interaction surface [polypeptide binding]; other site 267747001481 thiocarboxylated glycine; other site 267747001482 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 267747001483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747001484 FeS/SAM binding site; other site 267747001485 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 267747001486 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 267747001487 DNA binding residues [nucleotide binding] 267747001488 TOBE domain; Region: TOBE_2; cl01440 267747001489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747001490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001491 dimer interface [polypeptide binding]; other site 267747001492 conserved gate region; other site 267747001493 putative PBP binding loops; other site 267747001494 ABC-ATPase subunit interface; other site 267747001495 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 267747001496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747001497 Walker A/P-loop; other site 267747001498 ATP binding site [chemical binding]; other site 267747001499 Q-loop/lid; other site 267747001500 ABC transporter signature motif; other site 267747001501 Walker B; other site 267747001502 D-loop; other site 267747001503 H-loop/switch region; other site 267747001504 Predicted transcriptional regulator [Transcription]; Region: COG2345 267747001505 Helix-turn-helix domains; Region: HTH; cl00088 267747001506 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 267747001507 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 267747001508 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 267747001509 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 267747001510 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 267747001511 [4Fe-4S] binding site [ion binding]; other site 267747001512 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 267747001513 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 267747001514 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 267747001515 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 267747001516 molybdopterin cofactor binding site; other site 267747001517 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 267747001518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001519 putative substrate translocation pore; other site 267747001520 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 267747001521 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 267747001522 GTP binding site; other site 267747001523 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 267747001524 MPT binding site; other site 267747001525 trimer interface [polypeptide binding]; other site 267747001526 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869 267747001527 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 267747001528 4Fe-4S binding domain; Region: Fer4; cl02805 267747001529 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 267747001530 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 267747001531 putative [Fe4-S4] binding site [ion binding]; other site 267747001532 putative molybdopterin cofactor binding site [chemical binding]; other site 267747001533 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 267747001534 putative molybdopterin cofactor binding site; other site 267747001535 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 267747001536 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 267747001537 ATP binding site [chemical binding]; other site 267747001538 substrate interface [chemical binding]; other site 267747001539 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 267747001540 ThiS interaction site; other site 267747001541 putative active site [active] 267747001542 tetramer interface [polypeptide binding]; other site 267747001543 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 267747001544 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 267747001545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001546 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 267747001547 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 267747001548 Permease family; Region: Xan_ur_permease; cl00967 267747001549 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 267747001550 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 267747001551 Predicted methyltransferases [General function prediction only]; Region: COG0313 267747001552 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747001553 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 267747001554 active site 267747001555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747001556 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 267747001557 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 267747001558 Helix-turn-helix domains; Region: HTH; cl00088 267747001559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747001560 Helix-turn-helix domains; Region: HTH; cl00088 267747001561 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 267747001562 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 267747001563 Substrate binding site; other site 267747001564 Mg++ binding site; other site 267747001565 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 267747001566 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 267747001567 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747001568 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 267747001569 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 267747001570 5S rRNA interface [nucleotide binding]; other site 267747001571 CTC domain interface [polypeptide binding]; other site 267747001572 L16 interface [polypeptide binding]; other site 267747001573 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 267747001574 putative active site [active] 267747001575 catalytic residue [active] 267747001576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001577 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 267747001578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001579 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 267747001580 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 267747001581 putative NAD(P) binding site [chemical binding]; other site 267747001582 catalytic Zn binding site [ion binding]; other site 267747001583 structural Zn binding site [ion binding]; other site 267747001584 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 267747001585 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 267747001586 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 267747001587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747001588 ATP binding site [chemical binding]; other site 267747001589 putative Mg++ binding site [ion binding]; other site 267747001590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747001591 nucleotide binding region [chemical binding]; other site 267747001592 ATP-binding site [chemical binding]; other site 267747001593 TRCF domain; Region: TRCF; cl04088 267747001594 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 267747001595 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 267747001596 enolase; Provisional; Region: eno; PRK00077 267747001597 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 267747001598 dimer interface [polypeptide binding]; other site 267747001599 metal binding site [ion binding]; metal-binding site 267747001600 substrate binding pocket [chemical binding]; other site 267747001601 Septum formation initiator; Region: DivIC; cl11433 267747001602 Protein of unknown function (DUF501); Region: DUF501; cl00652 267747001603 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 267747001604 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 267747001605 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 267747001606 nudix motif; other site 267747001607 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747001608 GtrA-like protein; Region: GtrA; cl00971 267747001609 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 267747001610 OPT oligopeptide transporter protein; Region: OPT; cl14607 267747001611 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 267747001612 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267747001613 active site 267747001614 catalytic tetrad [active] 267747001615 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 267747001616 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 267747001617 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 267747001618 ligand binding site [chemical binding]; other site 267747001619 active site 267747001620 UGI interface [polypeptide binding]; other site 267747001621 catalytic site [active] 267747001622 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 267747001623 Domain of unknown function DUF20; Region: UPF0118; cl00465 267747001624 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 267747001625 domain; Region: GreA_GreB_N; pfam03449 267747001626 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 267747001627 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 267747001628 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 267747001629 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 267747001630 catalytic residues [active] 267747001631 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 267747001632 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 267747001633 catalytic residue [active] 267747001634 putative FPP diphosphate binding site; other site 267747001635 putative FPP binding hydrophobic cleft; other site 267747001636 dimer interface [polypeptide binding]; other site 267747001637 putative IPP diphosphate binding site; other site 267747001638 Haemolysin-III related; Region: HlyIII; cl03831 267747001639 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 267747001640 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 267747001641 putative active site [active] 267747001642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747001643 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 267747001644 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 267747001645 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 267747001646 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 267747001647 generic binding surface II; other site 267747001648 generic binding surface I; other site 267747001649 Phosphoesterase family; Region: Phosphoesterase; cl15450 267747001650 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 267747001651 structural tetrad; other site 267747001652 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 267747001653 LytB protein; Region: LYTB; cl00507 267747001654 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 267747001655 RmuC family; Region: RmuC; pfam02646 267747001656 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 267747001657 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 267747001658 active site 267747001659 metal binding site [ion binding]; metal-binding site 267747001660 GTP-binding protein YchF; Reviewed; Region: PRK09601 267747001661 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 267747001662 G1 box; other site 267747001663 GTP/Mg2+ binding site [chemical binding]; other site 267747001664 Switch I region; other site 267747001665 G2 box; other site 267747001666 Switch II region; other site 267747001667 G3 box; other site 267747001668 G4 box; other site 267747001669 G5 box; other site 267747001670 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 267747001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001672 putative substrate translocation pore; other site 267747001673 Transcriptional regulators [Transcription]; Region: MarR; COG1846 267747001674 Helix-turn-helix domains; Region: HTH; cl00088 267747001675 OsmC-like protein; Region: OsmC; cl00767 267747001676 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 267747001677 potential catalytic triad [active] 267747001678 conserved cys residue [active] 267747001679 Amino acid permease; Region: AA_permease; cl00524 267747001680 Amidinotransferase; Region: Amidinotransf; cl12043 267747001681 ornithine carbamoyltransferase; Validated; Region: PRK02102 267747001682 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 267747001683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001684 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 267747001685 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 267747001686 putative substrate binding site [chemical binding]; other site 267747001687 nucleotide binding site [chemical binding]; other site 267747001688 nucleotide binding site [chemical binding]; other site 267747001689 homodimer interface [polypeptide binding]; other site 267747001690 arginine repressor; Provisional; Region: PRK03341 267747001691 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 267747001692 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 267747001693 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 267747001694 dimer interface [polypeptide binding]; other site 267747001695 putative active site [active] 267747001696 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 267747001697 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 267747001698 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 267747001699 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 267747001700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267747001701 active site 267747001702 catalytic tetrad [active] 267747001703 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 267747001704 dimer interface [polypeptide binding]; other site 267747001705 catalytic triad [active] 267747001706 peroxidatic and resolving cysteines [active] 267747001707 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747001708 Amino acid permease; Region: AA_permease; cl00524 267747001709 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 267747001710 active site 267747001711 catalytic site [active] 267747001712 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 267747001713 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 267747001714 LDH/MDH dimer interface [polypeptide binding]; other site 267747001715 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 267747001716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001717 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 267747001718 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747001719 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 267747001720 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 267747001721 heterodimer interface [polypeptide binding]; other site 267747001722 substrate interaction site [chemical binding]; other site 267747001723 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 267747001724 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 267747001725 active site 267747001726 substrate binding site [chemical binding]; other site 267747001727 coenzyme B12 binding site [chemical binding]; other site 267747001728 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 267747001729 B12 binding site [chemical binding]; other site 267747001730 cobalt ligand [ion binding]; other site 267747001731 membrane ATPase/protein kinase; Provisional; Region: PRK09435 267747001732 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747001733 GTP/Mg2+ binding site [chemical binding]; other site 267747001734 G5 box; other site 267747001735 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 267747001736 Walker A; other site 267747001737 G1 box; other site 267747001738 Switch I region; other site 267747001739 G2 box; other site 267747001740 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 267747001741 active site 267747001742 catalytic triad [active] 267747001743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267747001744 RNA binding surface [nucleotide binding]; other site 267747001745 thymidine phosphorylase; Provisional; Region: PRK04350 267747001746 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 267747001747 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 267747001748 Walker A/P-loop; other site 267747001749 ATP binding site [chemical binding]; other site 267747001750 Q-loop/lid; other site 267747001751 ABC transporter signature motif; other site 267747001752 Walker B; other site 267747001753 D-loop; other site 267747001754 H-loop/switch region; other site 267747001755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001756 dimer interface [polypeptide binding]; other site 267747001757 ABC-ATPase subunit interface; other site 267747001758 putative PBP binding loops; other site 267747001759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747001760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747001761 DNA binding site [nucleotide binding] 267747001762 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 267747001763 ligand binding site [chemical binding]; other site 267747001764 dimerization interface (open form) [polypeptide binding]; other site 267747001765 dimerization interface (closed form) [polypeptide binding]; other site 267747001766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747001767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747001768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747001769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747001770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747001771 dimer interface [polypeptide binding]; other site 267747001772 conserved gate region; other site 267747001773 putative PBP binding loops; other site 267747001774 ABC-ATPase subunit interface; other site 267747001775 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 267747001776 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 267747001777 trimer interface [polypeptide binding]; other site 267747001778 hexamer (dimer of trimers) interface [polypeptide binding]; other site 267747001779 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 267747001780 substrate binding site [chemical binding]; other site 267747001781 Mn binding site [ion binding]; other site 267747001782 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 267747001783 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747001784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747001785 Walker A/P-loop; other site 267747001786 ATP binding site [chemical binding]; other site 267747001787 Q-loop/lid; other site 267747001788 ABC transporter signature motif; other site 267747001789 Walker B; other site 267747001790 D-loop; other site 267747001791 H-loop/switch region; other site 267747001792 FtsX-like permease family; Region: FtsX; pfam02687 267747001793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 267747001794 dimer interface [polypeptide binding]; other site 267747001795 putative PBP binding regions; other site 267747001796 ABC-ATPase subunit interface; other site 267747001797 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 267747001798 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 267747001799 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747001800 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 267747001801 intersubunit interface [polypeptide binding]; other site 267747001802 Isochorismatase family; Region: Isochorismatase; pfam00857 267747001803 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 267747001804 catalytic triad [active] 267747001805 conserved cis-peptide bond; other site 267747001806 Sodium:solute symporter family; Region: SSF; cl00456 267747001807 Proline dehydrogenase; Region: Pro_dh; cl03282 267747001808 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 267747001809 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 267747001810 Glutamate binding site [chemical binding]; other site 267747001811 NAD binding site [chemical binding]; other site 267747001812 catalytic residues [active] 267747001813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 267747001814 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 267747001815 putative NAD(P) binding site [chemical binding]; other site 267747001816 catalytic Zn binding site [ion binding]; other site 267747001817 dihydroxyacetone kinase; Provisional; Region: PRK14479 267747001818 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 267747001819 DAK2 domain; Region: Dak2; cl03685 267747001820 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747001821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267747001822 Coenzyme A binding pocket [chemical binding]; other site 267747001823 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747001824 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 267747001825 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 267747001826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747001827 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 267747001828 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 267747001829 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 267747001830 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 267747001831 4Fe-4S binding domain; Region: Fer4; cl02805 267747001832 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 267747001833 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 267747001834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747001835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747001836 homodimer interface [polypeptide binding]; other site 267747001837 catalytic residue [active] 267747001838 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 267747001839 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 267747001840 putative trimer interface [polypeptide binding]; other site 267747001841 putative CoA binding site [chemical binding]; other site 267747001842 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 267747001843 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 267747001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001845 metabolite-proton symporter; Region: 2A0106; TIGR00883 267747001846 putative substrate translocation pore; other site 267747001847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747001848 Helix-turn-helix domains; Region: HTH; cl00088 267747001849 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 267747001850 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 267747001851 metal binding site [ion binding]; metal-binding site 267747001852 putative dimer interface [polypeptide binding]; other site 267747001853 DivIVA domain; Region: DivI1A_domain; TIGR03544 267747001854 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 267747001855 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 267747001856 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 267747001857 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 267747001858 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 267747001859 ligand binding site; other site 267747001860 oligomer interface; other site 267747001861 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 267747001862 dimer interface [polypeptide binding]; other site 267747001863 N-terminal domain interface [polypeptide binding]; other site 267747001864 sulfate 1 binding site; other site 267747001865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747001866 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 267747001867 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 267747001868 dimer interface [polypeptide binding]; other site 267747001869 active site 267747001870 catalytic residue [active] 267747001871 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 267747001872 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 267747001873 Domain of unknown function DUF59; Region: DUF59; cl00941 267747001874 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 267747001875 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 267747001876 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 267747001877 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 267747001878 MgtE intracellular N domain; Region: MgtE_N; cl15244 267747001879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 267747001880 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 267747001881 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 267747001882 proline aminopeptidase P II; Provisional; Region: PRK10879 267747001883 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 267747001884 active site 267747001885 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 267747001886 Putative zinc ribbon domain; Region: DUF164; pfam02591 267747001887 YcfA-like protein; Region: YcfA; cl00752 267747001888 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 267747001889 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 267747001890 putative ligand binding residues [chemical binding]; other site 267747001891 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747001892 ABC-ATPase subunit interface; other site 267747001893 dimer interface [polypeptide binding]; other site 267747001894 putative PBP binding regions; other site 267747001895 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747001896 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747001897 Walker A/P-loop; other site 267747001898 ATP binding site [chemical binding]; other site 267747001899 Q-loop/lid; other site 267747001900 ABC transporter signature motif; other site 267747001901 Walker B; other site 267747001902 D-loop; other site 267747001903 H-loop/switch region; other site 267747001904 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 267747001905 dimer interface [polypeptide binding]; other site 267747001906 [2Fe-2S] cluster binding site [ion binding]; other site 267747001907 Carbon starvation protein CstA; Region: CstA; cl00856 267747001908 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 267747001909 active site 267747001910 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 267747001911 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 267747001912 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 267747001913 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 267747001914 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 267747001915 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 267747001916 metal binding triad; other site 267747001917 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 267747001918 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 267747001919 metal binding triad; other site 267747001920 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 267747001921 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 267747001922 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 267747001923 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 267747001924 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 267747001925 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 267747001926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 267747001927 putative active site [active] 267747001928 glutamine synthetase, type I; Region: GlnA; TIGR00653 267747001929 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 267747001930 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 267747001931 RDD family; Region: RDD; cl00746 267747001932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267747001933 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 267747001934 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 267747001935 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747001936 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 267747001937 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 267747001938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747001939 DNA-binding site [nucleotide binding]; DNA binding site 267747001940 UTRA domain; Region: UTRA; cl01230 267747001941 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 267747001942 active site turn [active] 267747001943 phosphorylation site [posttranslational modification] 267747001944 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 267747001945 active site turn [active] 267747001946 phosphorylation site [posttranslational modification] 267747001947 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 267747001948 HPr interaction site; other site 267747001949 glycerol kinase (GK) interaction site [polypeptide binding]; other site 267747001950 active site 267747001951 phosphorylation site [posttranslational modification] 267747001952 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 267747001953 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 267747001954 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267747001955 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 267747001956 ABC transporter; Region: ABC_tran_2; pfam12848 267747001957 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 267747001958 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 267747001959 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 267747001960 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 267747001961 Asp-box motif; other site 267747001962 catalytic site [active] 267747001963 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 267747001964 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 267747001965 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 267747001966 Asp-box motif; other site 267747001967 catalytic site [active] 267747001968 putative sialic acid transporter; Provisional; Region: PRK03893 267747001969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747001970 putative substrate translocation pore; other site 267747001971 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 267747001972 lipoyl synthase; Provisional; Region: PRK05481 267747001973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747001974 FeS/SAM binding site; other site 267747001975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 267747001976 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 267747001977 metal-binding site [ion binding] 267747001978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 267747001979 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747001980 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 267747001981 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 267747001982 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 267747001983 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 267747001984 E3 interaction surface; other site 267747001985 lipoyl attachment site [posttranslational modification]; other site 267747001986 e3 binding domain; Region: E3_binding; pfam02817 267747001987 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 267747001988 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 267747001989 multifunctional aminopeptidase A; Provisional; Region: PRK00913 267747001990 interface (dimer of trimers) [polypeptide binding]; other site 267747001991 Substrate-binding/catalytic site; other site 267747001992 Zn-binding sites [ion binding]; other site 267747001993 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 267747001994 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 267747001995 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 267747001996 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 267747001997 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 267747001998 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 267747001999 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 267747002000 D-pathway; other site 267747002001 Putative ubiquinol binding site [chemical binding]; other site 267747002002 Low-spin heme (heme b) binding site [chemical binding]; other site 267747002003 Putative water exit pathway; other site 267747002004 Binuclear center (heme o3/CuB) [ion binding]; other site 267747002005 K-pathway; other site 267747002006 Putative proton exit pathway; other site 267747002007 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 267747002008 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747002009 Walker A/P-loop; other site 267747002010 ATP binding site [chemical binding]; other site 267747002011 Q-loop/lid; other site 267747002012 ABC transporter signature motif; other site 267747002013 Walker B; other site 267747002014 D-loop; other site 267747002015 H-loop/switch region; other site 267747002016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747002017 NAD(P) binding site [chemical binding]; other site 267747002018 active site 267747002019 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 267747002020 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 267747002021 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 267747002022 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 267747002023 active site 267747002024 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 267747002025 active site 267747002026 DNA binding site [nucleotide binding] 267747002027 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 267747002028 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 267747002029 heme bL binding site [chemical binding]; other site 267747002030 interchain domain interface [polypeptide binding]; other site 267747002031 intrachain domain interface; other site 267747002032 heme bH binding site [chemical binding]; other site 267747002033 Qo binding site; other site 267747002034 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 267747002035 iron-sulfur cluster [ion binding]; other site 267747002036 [2Fe-2S] cluster binding site [ion binding]; other site 267747002037 Cytochrome c; Region: Cytochrom_C; cl11414 267747002038 Cytochrome c; Region: Cytochrom_C; cl11414 267747002039 Cytochrome c; Region: Cytochrom_C; cl11414 267747002040 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 267747002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 267747002042 active site 267747002043 phosphorylation site [posttranslational modification] 267747002044 intermolecular recognition site; other site 267747002045 dimerization interface [polypeptide binding]; other site 267747002046 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 267747002047 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 267747002048 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 267747002049 active site 267747002050 Rhomboid family; Region: Rhomboid; cl11446 267747002051 hypothetical protein; Validated; Region: PRK07883 267747002052 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 267747002053 active site 267747002054 substrate binding site [chemical binding]; other site 267747002055 catalytic site [active] 267747002056 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 267747002057 GIY-YIG motif/motif A; other site 267747002058 active site 267747002059 catalytic site [active] 267747002060 putative DNA binding site [nucleotide binding]; other site 267747002061 metal binding site [ion binding]; metal-binding site 267747002062 NlpC/P60 family; Region: NLPC_P60; cl11438 267747002063 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 267747002064 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747002065 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267747002066 putative acyl-acceptor binding pocket; other site 267747002067 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747002068 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 267747002069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267747002070 EamA-like transporter family; Region: EamA; cl01037 267747002071 EamA-like transporter family; Region: EamA; cl01037 267747002072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 267747002073 Catalytic domain of Protein Kinases; Region: PKc; cd00180 267747002074 active site 267747002075 ATP binding site [chemical binding]; other site 267747002076 substrate binding site [chemical binding]; other site 267747002077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267747002078 substrate binding site [chemical binding]; other site 267747002079 activation loop (A-loop); other site 267747002080 activation loop (A-loop); other site 267747002081 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 267747002082 active site 267747002083 barstar interaction site; other site 267747002084 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 267747002085 putative RNAase interaction site [polypeptide binding]; other site 267747002086 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 267747002087 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 267747002088 substrate binding pocket [chemical binding]; other site 267747002089 chain length determination region; other site 267747002090 substrate-Mg2+ binding site; other site 267747002091 catalytic residues [active] 267747002092 aspartate-rich region 1; other site 267747002093 active site lid residues [active] 267747002094 aspartate-rich region 2; other site 267747002095 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 267747002096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002098 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 267747002099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267747002100 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 267747002101 putative dimer interface [polypeptide binding]; other site 267747002102 gluconate transporter; Region: gntP; TIGR00791 267747002103 GntP family permease; Region: GntP_permease; cl15264 267747002104 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 267747002105 ATP-binding site [chemical binding]; other site 267747002106 Gluconate-6-phosphate binding site [chemical binding]; other site 267747002107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747002108 DNA-binding site [nucleotide binding]; DNA binding site 267747002109 FCD domain; Region: FCD; cl11656 267747002110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747002111 DNA-binding site [nucleotide binding]; DNA binding site 267747002112 FCD domain; Region: FCD; cl11656 267747002113 glycine dehydrogenase; Provisional; Region: PRK05367 267747002114 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 267747002115 tetramer interface [polypeptide binding]; other site 267747002116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747002117 catalytic residue [active] 267747002118 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 267747002119 tetramer interface [polypeptide binding]; other site 267747002120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747002121 catalytic residue [active] 267747002122 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 267747002123 lipoyl attachment site [posttranslational modification]; other site 267747002124 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 267747002125 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 267747002126 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 267747002127 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 267747002128 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 267747002129 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 267747002130 MoxR-like ATPases [General function prediction only]; Region: COG0714 267747002131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747002132 ATP binding site [chemical binding]; other site 267747002133 Walker A motif; other site 267747002134 Walker B motif; other site 267747002135 arginine finger; other site 267747002136 cell division protein MraZ; Reviewed; Region: PRK00326 267747002137 MraZ protein; Region: MraZ; pfam02381 267747002138 MraZ protein; Region: MraZ; pfam02381 267747002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747002140 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 267747002141 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 267747002142 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 267747002143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747002144 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 267747002145 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 267747002146 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 267747002147 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267747002148 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 267747002149 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 267747002150 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 267747002151 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267747002152 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 267747002153 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 267747002154 Mg++ binding site [ion binding]; other site 267747002155 putative catalytic motif [active] 267747002156 putative substrate binding site [chemical binding]; other site 267747002157 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 267747002158 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 267747002159 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267747002160 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 267747002161 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 267747002162 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 267747002163 active site 267747002164 homodimer interface [polypeptide binding]; other site 267747002165 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 267747002166 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 267747002167 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 267747002168 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267747002169 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 267747002170 Cell division protein FtsQ; Region: FtsQ; pfam03799 267747002171 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 267747002172 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 267747002173 nucleotide binding site [chemical binding]; other site 267747002174 SulA interaction site; other site 267747002175 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 267747002176 Protein of unknown function (DUF552); Region: DUF552; cl00775 267747002177 DivIVA protein; Region: DivIVA; pfam05103 267747002178 DivIVA domain; Region: DivI1A_domain; TIGR03544 267747002179 V-type ATP synthase subunit E; Provisional; Region: PRK02292 267747002180 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 267747002181 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 267747002182 lipoprotein signal peptidase; Provisional; Region: PRK14787 267747002183 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 267747002184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267747002185 RNA binding surface [nucleotide binding]; other site 267747002186 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 267747002187 active site 267747002188 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 267747002189 pyruvate kinase; Provisional; Region: PRK06247 267747002190 domain interfaces; other site 267747002191 active site 267747002192 CrcB-like protein; Region: CRCB; cl09114 267747002193 CrcB-like protein; Region: CRCB; cl09114 267747002194 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 267747002195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747002196 active site 267747002197 phosphorylation site [posttranslational modification] 267747002198 intermolecular recognition site; other site 267747002199 dimerization interface [polypeptide binding]; other site 267747002200 ANTAR domain; Region: ANTAR; cl04297 267747002201 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 267747002202 CoenzymeA binding site [chemical binding]; other site 267747002203 subunit interaction site [polypeptide binding]; other site 267747002204 PHB binding site; other site 267747002205 DNA polymerase I; Provisional; Region: PRK05755 267747002206 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 267747002207 active site 267747002208 metal binding site 1 [ion binding]; metal-binding site 267747002209 putative 5' ssDNA interaction site; other site 267747002210 metal binding site 3; metal-binding site 267747002211 metal binding site 2 [ion binding]; metal-binding site 267747002212 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 267747002213 putative DNA binding site [nucleotide binding]; other site 267747002214 putative metal binding site [ion binding]; other site 267747002215 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 267747002216 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 267747002217 active site 267747002218 DNA binding site [nucleotide binding] 267747002219 catalytic site [active] 267747002220 FAD binding domain; Region: FAD_binding_4; pfam01565 267747002221 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 267747002222 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 267747002223 FAD binding domain; Region: FAD_binding_4; pfam01565 267747002224 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 267747002225 active site 267747002226 putative catalytic site [active] 267747002227 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 267747002228 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 267747002229 RNA binding site [nucleotide binding]; other site 267747002230 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 267747002231 RNA binding site [nucleotide binding]; other site 267747002232 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267747002233 RNA binding site [nucleotide binding]; other site 267747002234 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 267747002235 RNA binding site [nucleotide binding]; other site 267747002236 domain interface; other site 267747002237 Htaa; Region: HtaA; pfam04213 267747002238 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 267747002239 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747002240 intersubunit interface [polypeptide binding]; other site 267747002241 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747002242 ABC-ATPase subunit interface; other site 267747002243 dimer interface [polypeptide binding]; other site 267747002244 putative PBP binding regions; other site 267747002245 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 267747002246 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747002247 Walker A/P-loop; other site 267747002248 ATP binding site [chemical binding]; other site 267747002249 Q-loop/lid; other site 267747002250 ABC transporter signature motif; other site 267747002251 Walker B; other site 267747002252 D-loop; other site 267747002253 H-loop/switch region; other site 267747002254 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747002255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747002257 Walker A/P-loop; other site 267747002258 ATP binding site [chemical binding]; other site 267747002259 Q-loop/lid; other site 267747002260 ABC transporter signature motif; other site 267747002261 Walker B; other site 267747002262 D-loop; other site 267747002263 H-loop/switch region; other site 267747002264 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 267747002265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002266 Walker A/P-loop; other site 267747002267 ATP binding site [chemical binding]; other site 267747002268 Q-loop/lid; other site 267747002269 ABC transporter signature motif; other site 267747002270 Walker B; other site 267747002271 D-loop; other site 267747002272 H-loop/switch region; other site 267747002273 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 267747002274 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 267747002275 CoA-binding site [chemical binding]; other site 267747002276 ATP-binding [chemical binding]; other site 267747002277 Htaa; Region: HtaA; pfam04213 267747002278 Htaa; Region: HtaA; pfam04213 267747002279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002280 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 267747002281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002282 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 267747002283 metal ion-dependent adhesion site (MIDAS); other site 267747002284 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 267747002285 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 267747002286 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 267747002287 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747002288 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747002289 Walker A/P-loop; other site 267747002290 ATP binding site [chemical binding]; other site 267747002291 Q-loop/lid; other site 267747002292 ABC transporter signature motif; other site 267747002293 Walker B; other site 267747002294 D-loop; other site 267747002295 H-loop/switch region; other site 267747002296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747002297 ABC-ATPase subunit interface; other site 267747002298 dimer interface [polypeptide binding]; other site 267747002299 putative PBP binding regions; other site 267747002300 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747002301 intersubunit interface [polypeptide binding]; other site 267747002302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002303 ABC transporter signature motif; other site 267747002304 Walker B; other site 267747002305 D-loop; other site 267747002306 H-loop/switch region; other site 267747002307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002308 Walker A/P-loop; other site 267747002309 ATP binding site [chemical binding]; other site 267747002310 Q-loop/lid; other site 267747002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 267747002312 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 267747002313 excinuclease ABC subunit B; Provisional; Region: PRK05298 267747002314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747002316 nucleotide binding region [chemical binding]; other site 267747002317 ATP-binding site [chemical binding]; other site 267747002318 Ultra-violet resistance protein B; Region: UvrB; pfam12344 267747002319 UvrB/uvrC motif; Region: UVR; pfam02151 267747002320 Integral membrane protein TerC family; Region: TerC; cl10468 267747002321 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267747002322 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 267747002323 DinB superfamily; Region: DinB_2; cl00986 267747002324 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 267747002325 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 267747002326 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 267747002327 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 267747002328 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 267747002329 iron-sulfur cluster [ion binding]; other site 267747002330 [2Fe-2S] cluster binding site [ion binding]; other site 267747002331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747002332 catalytic core [active] 267747002333 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 267747002334 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 267747002335 GIY-YIG motif/motif A; other site 267747002336 active site 267747002337 catalytic site [active] 267747002338 putative DNA binding site [nucleotide binding]; other site 267747002339 metal binding site [ion binding]; metal-binding site 267747002340 UvrB/uvrC motif; Region: UVR; pfam02151 267747002341 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 267747002342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002343 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 267747002344 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 267747002345 phosphate binding site [ion binding]; other site 267747002346 putative substrate binding pocket [chemical binding]; other site 267747002347 dimer interface [polypeptide binding]; other site 267747002348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 267747002349 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 267747002350 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 267747002351 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 267747002352 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 267747002353 Phosphoglycerate kinase; Region: PGK; pfam00162 267747002354 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 267747002355 substrate binding site [chemical binding]; other site 267747002356 hinge regions; other site 267747002357 ADP binding site [chemical binding]; other site 267747002358 catalytic site [active] 267747002359 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 267747002360 substrate binding site [chemical binding]; other site 267747002361 dimer interface [polypeptide binding]; other site 267747002362 catalytic triad [active] 267747002363 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 267747002364 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 267747002365 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 267747002366 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 267747002367 active site 267747002368 multimer interface [polypeptide binding]; other site 267747002369 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 267747002370 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 267747002371 B12 binding site [chemical binding]; other site 267747002372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747002373 FeS/SAM binding site; other site 267747002374 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 267747002375 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 267747002376 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 267747002377 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 267747002378 homodimer interface [polypeptide binding]; other site 267747002379 oligonucleotide binding site [chemical binding]; other site 267747002380 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 267747002381 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 267747002382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747002383 Helix-turn-helix domains; Region: HTH; cl00088 267747002384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747002385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267747002386 putative substrate translocation pore; other site 267747002387 GTPase CgtA; Reviewed; Region: obgE; PRK12296 267747002388 GTP1/OBG; Region: GTP1_OBG; pfam01018 267747002389 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 267747002390 G1 box; other site 267747002391 GTP/Mg2+ binding site [chemical binding]; other site 267747002392 Switch I region; other site 267747002393 G2 box; other site 267747002394 G3 box; other site 267747002395 Switch II region; other site 267747002396 G4 box; other site 267747002397 G5 box; other site 267747002398 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 267747002399 gamma-glutamyl kinase; Provisional; Region: PRK05429 267747002400 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 267747002401 nucleotide binding site [chemical binding]; other site 267747002402 homotetrameric interface [polypeptide binding]; other site 267747002403 putative phosphate binding site [ion binding]; other site 267747002404 putative allosteric binding site; other site 267747002405 PUA domain; Region: PUA; cl00607 267747002406 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 267747002407 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 267747002408 putative catalytic cysteine [active] 267747002409 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 267747002410 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 267747002411 active site 267747002412 (T/H)XGH motif; other site 267747002413 Domain of unknown function DUF143; Region: DUF143; cl00519 267747002414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267747002415 catalytic core [active] 267747002416 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 267747002417 substrate binding site [chemical binding]; other site 267747002418 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 267747002419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002420 Walker A/P-loop; other site 267747002421 ATP binding site [chemical binding]; other site 267747002422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002423 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267747002424 H-loop/switch region; other site 267747002425 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267747002426 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 267747002427 TrwC relaxase; Region: TrwC; cl08490 267747002428 TrwC relaxase; Region: TrwC; cl08490 267747002429 TrwC relaxase; Region: TrwC; cl08490 267747002430 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 267747002431 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 267747002432 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 267747002433 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 267747002434 putative active site [active] 267747002435 putative metal-binding site [ion binding]; other site 267747002436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002437 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 267747002438 Transposase; Region: DDE_Tnp_ISL3; pfam01610 267747002439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 267747002440 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 267747002441 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 267747002442 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 267747002443 YcaO-like family; Region: YcaO; cl09146 267747002444 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 267747002445 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 267747002446 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 267747002447 FMN binding site [chemical binding]; other site 267747002448 dimer interface [polypeptide binding]; other site 267747002449 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 267747002450 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 267747002451 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 267747002452 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 267747002453 Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262 267747002454 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 267747002455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747002456 DNA-binding site [nucleotide binding]; DNA binding site 267747002457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747002458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747002459 homodimer interface [polypeptide binding]; other site 267747002460 catalytic residue [active] 267747002461 Transposase; Region: DDE_Tnp_ISL3; pfam01610 267747002462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002463 Walker A/P-loop; other site 267747002464 ATP binding site [chemical binding]; other site 267747002465 Q-loop/lid; other site 267747002466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002467 ABC transporter signature motif; other site 267747002468 Walker B; other site 267747002469 D-loop; other site 267747002470 H-loop/switch region; other site 267747002471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002472 Walker A/P-loop; other site 267747002473 ATP binding site [chemical binding]; other site 267747002474 Q-loop/lid; other site 267747002475 ABC transporter signature motif; other site 267747002476 Walker B; other site 267747002477 D-loop; other site 267747002478 H-loop/switch region; other site 267747002479 Helix-turn-helix domains; Region: HTH; cl00088 267747002480 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 267747002481 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 267747002482 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 267747002483 active site 267747002484 substrate binding pocket [chemical binding]; other site 267747002485 homodimer interaction site [polypeptide binding]; other site 267747002486 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 267747002487 active site 267747002488 dimer interface [polypeptide binding]; other site 267747002489 magnesium binding site [ion binding]; other site 267747002490 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 267747002491 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 267747002492 AP (apurinic/apyrimidinic) site pocket; other site 267747002493 DNA interaction; other site 267747002494 Metal-binding active site; metal-binding site 267747002495 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 267747002496 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 267747002497 intersubunit interface [polypeptide binding]; other site 267747002498 active site 267747002499 Zn2+ binding site [ion binding]; other site 267747002500 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267747002501 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 267747002502 substrate binding site [chemical binding]; other site 267747002503 ATP binding site [chemical binding]; other site 267747002504 benzoate transport; Region: 2A0115; TIGR00895 267747002505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747002506 putative substrate translocation pore; other site 267747002507 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 267747002508 substrate binding site [chemical binding]; other site 267747002509 multimerization interface [polypeptide binding]; other site 267747002510 ATP binding site [chemical binding]; other site 267747002511 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 267747002512 thiamine phosphate binding site [chemical binding]; other site 267747002513 active site 267747002514 pyrophosphate binding site [ion binding]; other site 267747002515 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 267747002516 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 267747002517 dimer interface [polypeptide binding]; other site 267747002518 NAD binding site [chemical binding]; other site 267747002519 substrate binding site [chemical binding]; other site 267747002520 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267747002521 malate dehydrogenase; Provisional; Region: PRK13529 267747002522 Malic enzyme, N-terminal domain; Region: malic; pfam00390 267747002523 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 267747002524 NAD(P) binding site [chemical binding]; other site 267747002525 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 267747002526 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 267747002527 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 267747002528 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 267747002529 HIGH motif; other site 267747002530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747002531 active site 267747002532 KMSKS motif; other site 267747002533 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 267747002534 tRNA binding surface [nucleotide binding]; other site 267747002535 SLBB domain; Region: SLBB; pfam10531 267747002536 comEA protein; Region: comE; TIGR01259 267747002537 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 267747002538 Competence protein; Region: Competence; cl00471 267747002539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267747002540 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 267747002541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747002542 ATP binding site [chemical binding]; other site 267747002543 putative Mg++ binding site [ion binding]; other site 267747002544 hypothetical protein; Reviewed; Region: PRK07914 267747002545 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 267747002546 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 267747002547 GTP-binding protein LepA; Provisional; Region: PRK05433 267747002548 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 267747002549 G1 box; other site 267747002550 putative GEF interaction site [polypeptide binding]; other site 267747002551 GTP/Mg2+ binding site [chemical binding]; other site 267747002552 Switch I region; other site 267747002553 G2 box; other site 267747002554 G3 box; other site 267747002555 Switch II region; other site 267747002556 G4 box; other site 267747002557 G5 box; other site 267747002558 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 267747002559 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 267747002560 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 267747002561 O-succinylbenzoate synthase; Provisional; Region: PRK02901 267747002562 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 267747002563 active site 267747002564 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 267747002565 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 267747002566 dimer interface [polypeptide binding]; other site 267747002567 tetramer interface [polypeptide binding]; other site 267747002568 PYR/PP interface [polypeptide binding]; other site 267747002569 TPP binding site [chemical binding]; other site 267747002570 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 267747002571 TPP-binding site; other site 267747002572 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 267747002573 chorismate binding enzyme; Region: Chorismate_bind; cl10555 267747002574 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747002575 naphthoate synthase; Validated; Region: PRK08321 267747002576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267747002577 substrate binding site [chemical binding]; other site 267747002578 oxyanion hole (OAH) forming residues; other site 267747002579 trimer interface [polypeptide binding]; other site 267747002580 Rhomboid family; Region: Rhomboid; cl11446 267747002581 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 267747002582 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747002583 acetyl-CoA synthetase; Provisional; Region: PRK00174 267747002584 coproporphyrinogen III oxidase; Validated; Region: PRK05628 267747002585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747002586 FeS/SAM binding site; other site 267747002587 HemN C-terminal region; Region: HemN_C; pfam06969 267747002588 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 267747002589 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 267747002590 active site 267747002591 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267747002592 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 267747002593 HrcA protein C terminal domain; Region: HrcA; pfam01628 267747002594 chaperone protein DnaJ; Provisional; Region: PRK14278 267747002595 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 267747002596 HSP70 interaction site [polypeptide binding]; other site 267747002597 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 267747002598 Zn binding sites [ion binding]; other site 267747002599 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 267747002600 dimer interface [polypeptide binding]; other site 267747002601 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 267747002602 RNA methyltransferase, RsmE family; Region: TIGR00046 267747002603 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 267747002604 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 267747002605 putative NAD(P) binding site [chemical binding]; other site 267747002606 catalytic Zn binding site [ion binding]; other site 267747002607 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 267747002608 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747002609 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 267747002610 active site 267747002611 P-loop; other site 267747002612 phosphorylation site [posttranslational modification] 267747002613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747002614 active site 267747002615 phosphorylation site [posttranslational modification] 267747002616 DoxX; Region: DoxX; cl00976 267747002617 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 267747002618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747002619 ATP binding site [chemical binding]; other site 267747002620 putative Mg++ binding site [ion binding]; other site 267747002621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747002622 nucleotide binding region [chemical binding]; other site 267747002623 ATP-binding site [chemical binding]; other site 267747002624 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 267747002625 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 267747002626 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 267747002627 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 267747002628 EamA-like transporter family; Region: EamA; cl01037 267747002629 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 267747002630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267747002631 Histidine kinase; Region: HisKA_3; pfam07730 267747002632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747002633 ATP binding site [chemical binding]; other site 267747002634 Mg2+ binding site [ion binding]; other site 267747002635 G-X-G motif; other site 267747002636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267747002637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747002638 active site 267747002639 phosphorylation site [posttranslational modification] 267747002640 intermolecular recognition site; other site 267747002641 dimerization interface [polypeptide binding]; other site 267747002642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267747002643 DNA binding residues [nucleotide binding] 267747002644 dimerization interface [polypeptide binding]; other site 267747002645 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 267747002646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002647 Walker A/P-loop; other site 267747002648 ATP binding site [chemical binding]; other site 267747002649 Q-loop/lid; other site 267747002650 ABC transporter signature motif; other site 267747002651 Walker B; other site 267747002652 D-loop; other site 267747002653 H-loop/switch region; other site 267747002654 ABC-2 type transporter; Region: ABC2_membrane; cl11417 267747002655 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 267747002656 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 267747002657 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 267747002658 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 267747002659 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 267747002660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002661 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 267747002662 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 267747002663 Domain of unknown function DUF21; Region: DUF21; pfam01595 267747002664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 267747002665 Transporter associated domain; Region: CorC_HlyC; cl08393 267747002666 GTPase Era; Reviewed; Region: era; PRK00089 267747002667 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 267747002668 G1 box; other site 267747002669 GTP/Mg2+ binding site [chemical binding]; other site 267747002670 Switch I region; other site 267747002671 G2 box; other site 267747002672 Switch II region; other site 267747002673 G3 box; other site 267747002674 G4 box; other site 267747002675 G5 box; other site 267747002676 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 267747002677 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 267747002678 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 267747002679 active site 267747002680 2-isopropylmalate synthase; Validated; Region: PRK03739 267747002681 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 267747002682 active site 267747002683 catalytic residues [active] 267747002684 metal binding site [ion binding]; metal-binding site 267747002685 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 267747002686 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 267747002687 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 267747002688 catalytic residue [active] 267747002689 putative FPP diphosphate binding site; other site 267747002690 putative FPP binding hydrophobic cleft; other site 267747002691 dimer interface [polypeptide binding]; other site 267747002692 putative IPP diphosphate binding site; other site 267747002693 LysE type translocator; Region: LysE; cl00565 267747002694 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 267747002695 Recombination protein O N terminal; Region: RecO_N; pfam11967 267747002696 Recombination protein O C terminal; Region: RecO_C; pfam02565 267747002697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267747002698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267747002699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267747002700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747002701 active site 267747002702 phosphorylation site [posttranslational modification] 267747002703 intermolecular recognition site; other site 267747002704 dimerization interface [polypeptide binding]; other site 267747002705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267747002706 DNA binding residues [nucleotide binding] 267747002707 dimerization interface [polypeptide binding]; other site 267747002708 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 267747002709 metal binding site 2 [ion binding]; metal-binding site 267747002710 putative DNA binding helix; other site 267747002711 metal binding site 1 [ion binding]; metal-binding site 267747002712 dimer interface [polypeptide binding]; other site 267747002713 structural Zn2+ binding site [ion binding]; other site 267747002714 glycyl-tRNA synthetase; Provisional; Region: PRK04173 267747002715 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 267747002716 motif 1; other site 267747002717 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 267747002718 active site 267747002719 motif 2; other site 267747002720 motif 3; other site 267747002721 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 267747002722 anticodon binding site; other site 267747002723 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 267747002724 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 267747002725 putative Iron-sulfur protein interface [polypeptide binding]; other site 267747002726 proximal heme binding site [chemical binding]; other site 267747002727 distal heme binding site [chemical binding]; other site 267747002728 putative dimer interface [polypeptide binding]; other site 267747002729 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 267747002730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747002731 domain; Region: Succ_DH_flav_C; pfam02910 267747002732 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 267747002733 4Fe-4S binding domain; Region: Fer4; cl02805 267747002734 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 267747002735 putative FMN binding site [chemical binding]; other site 267747002736 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 267747002737 putative dimer interface [polypeptide binding]; other site 267747002738 active site pocket [active] 267747002739 putative cataytic base [active] 267747002740 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 267747002741 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 267747002742 FMN binding site [chemical binding]; other site 267747002743 active site 267747002744 catalytic residues [active] 267747002745 substrate binding site [chemical binding]; other site 267747002746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 267747002747 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 267747002748 DNA primase; Validated; Region: dnaG; PRK05667 267747002749 CHC2 zinc finger; Region: zf-CHC2; cl15369 267747002750 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 267747002751 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 267747002752 active site 267747002753 metal binding site [ion binding]; metal-binding site 267747002754 interdomain interaction site; other site 267747002755 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 267747002756 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 267747002757 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 267747002758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267747002759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267747002760 DNA binding residues [nucleotide binding] 267747002761 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267747002762 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 267747002763 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 267747002764 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 267747002765 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 267747002766 active site 267747002767 homotetramer interface [polypeptide binding]; other site 267747002768 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 267747002769 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747002770 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 267747002771 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 267747002772 dimer interface [polypeptide binding]; other site 267747002773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747002774 catalytic residue [active] 267747002775 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 267747002776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747002777 DNA-binding site [nucleotide binding]; DNA binding site 267747002778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747002779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747002780 homodimer interface [polypeptide binding]; other site 267747002781 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 267747002782 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 267747002783 active site 267747002784 multimer interface [polypeptide binding]; other site 267747002785 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 267747002786 predicted active site [active] 267747002787 catalytic triad [active] 267747002788 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 267747002789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 267747002790 inhibitor-cofactor binding pocket; inhibition site 267747002791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747002792 catalytic residue [active] 267747002793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002794 Amino acid permease; Region: AA_permease; cl00524 267747002795 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 267747002796 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747002797 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 267747002798 active site 267747002799 motif I; other site 267747002800 motif II; other site 267747002801 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747002802 MoxR-like ATPases [General function prediction only]; Region: COG0714 267747002803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747002804 Walker A motif; other site 267747002805 ATP binding site [chemical binding]; other site 267747002806 Walker B motif; other site 267747002807 arginine finger; other site 267747002808 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 267747002809 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 267747002810 hypothetical protein; Provisional; Region: PRK13685 267747002811 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 267747002812 metal ion-dependent adhesion site (MIDAS); other site 267747002813 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 267747002814 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 267747002815 metal ion-dependent adhesion site (MIDAS); other site 267747002816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 267747002817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267747002818 catalytic residue [active] 267747002819 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 267747002820 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 267747002821 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 267747002822 dimer interface [polypeptide binding]; other site 267747002823 active site 267747002824 Phosphopantetheine attachment site; Region: PP-binding; cl09936 267747002825 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 267747002826 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 267747002827 dimer interface [polypeptide binding]; other site 267747002828 active site 267747002829 CoA binding pocket [chemical binding]; other site 267747002830 Acyl transferase domain; Region: Acyl_transf_1; cl08282 267747002831 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 267747002832 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 267747002833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747002834 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 267747002835 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 267747002836 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 267747002837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747002838 putative substrate translocation pore; other site 267747002839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747002840 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 267747002841 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 267747002842 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 267747002843 dimer interface [polypeptide binding]; other site 267747002844 TPP-binding site [chemical binding]; other site 267747002845 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 267747002846 active site 267747002847 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 267747002848 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 267747002849 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 267747002850 Isochorismatase family; Region: Isochorismatase; pfam00857 267747002851 catalytic triad [active] 267747002852 metal binding site [ion binding]; metal-binding site 267747002853 conserved cis-peptide bond; other site 267747002854 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 267747002855 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267747002856 active site 267747002857 catalytic tetrad [active] 267747002858 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747002859 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 267747002860 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 267747002861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747002862 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 267747002863 dihydroorotase; Validated; Region: pyrC; PRK09357 267747002864 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 267747002865 active site 267747002866 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 267747002867 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 267747002868 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 267747002869 catalytic site [active] 267747002870 subunit interface [polypeptide binding]; other site 267747002871 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 267747002872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267747002873 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747002874 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267747002875 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747002876 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 267747002877 IMP binding site; other site 267747002878 dimer interface [polypeptide binding]; other site 267747002879 interdomain contacts; other site 267747002880 partial ornithine binding site; other site 267747002881 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 267747002882 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 267747002883 FAD binding pocket [chemical binding]; other site 267747002884 FAD binding motif [chemical binding]; other site 267747002885 phosphate binding motif [ion binding]; other site 267747002886 beta-alpha-beta structure motif; other site 267747002887 NAD binding pocket [chemical binding]; other site 267747002888 Iron coordination center [ion binding]; other site 267747002889 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 267747002890 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 267747002891 heterodimer interface [polypeptide binding]; other site 267747002892 active site 267747002893 FMN binding site [chemical binding]; other site 267747002894 homodimer interface [polypeptide binding]; other site 267747002895 substrate binding site [chemical binding]; other site 267747002896 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 267747002897 active site 267747002898 dimer interface [polypeptide binding]; other site 267747002899 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747002900 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 267747002901 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 267747002902 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 267747002903 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 267747002904 Competence-damaged protein; Region: CinA; cl00666 267747002905 Helix-turn-helix domains; Region: HTH; cl00088 267747002906 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 267747002907 Helix-turn-helix domains; Region: HTH; cl00088 267747002908 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747002909 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 267747002910 recombinase A; Provisional; Region: recA; PRK09354 267747002911 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 267747002912 hexamer interface [polypeptide binding]; other site 267747002913 Walker A motif; other site 267747002914 ATP binding site [chemical binding]; other site 267747002915 Walker B motif; other site 267747002916 RecX family; Region: RecX; cl00936 267747002917 phosphodiesterase; Provisional; Region: PRK12704 267747002918 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 267747002919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267747002920 Zn2+ binding site [ion binding]; other site 267747002921 Mg2+ binding site [ion binding]; other site 267747002922 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 267747002923 active site 267747002924 catalytic residues [active] 267747002925 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 267747002926 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 267747002927 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 267747002928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747002929 FeS/SAM binding site; other site 267747002930 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 267747002931 IPP transferase; Region: IPPT; cl00403 267747002932 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 267747002933 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 267747002934 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 267747002935 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 267747002936 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 267747002937 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 267747002938 G1 box; other site 267747002939 GTP/Mg2+ binding site [chemical binding]; other site 267747002940 Switch I region; other site 267747002941 G2 box; other site 267747002942 G3 box; other site 267747002943 Switch II region; other site 267747002944 G4 box; other site 267747002945 G5 box; other site 267747002946 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 267747002947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002949 putative Mg++ binding site [ion binding]; other site 267747002950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747002951 LexA repressor; Validated; Region: PRK00215 267747002952 Helix-turn-helix domains; Region: HTH; cl00088 267747002953 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 267747002954 Catalytic site [active] 267747002955 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 267747002956 ATP cone domain; Region: ATP-cone; pfam03477 267747002957 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 267747002958 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 267747002959 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 267747002960 active site 267747002961 dimer interface [polypeptide binding]; other site 267747002962 effector binding site; other site 267747002963 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 267747002964 TSCPD domain; Region: TSCPD; cl14834 267747002965 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 267747002966 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 267747002967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 267747002968 Ligand Binding Site [chemical binding]; other site 267747002969 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 267747002970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747002971 ATP binding site [chemical binding]; other site 267747002972 putative Mg++ binding site [ion binding]; other site 267747002973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747002974 nucleotide binding region [chemical binding]; other site 267747002975 ATP-binding site [chemical binding]; other site 267747002976 Helicase associated domain (HA2); Region: HA2; cl04503 267747002977 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 267747002978 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 267747002979 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 267747002980 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 267747002981 active site 267747002982 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 267747002983 catalytic triad [active] 267747002984 dimer interface [polypeptide binding]; other site 267747002985 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 267747002986 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 267747002987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267747002988 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 267747002989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 267747002990 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 267747002991 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 267747002992 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 267747002993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267747002994 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 267747002995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267747002996 DNA binding residues [nucleotide binding] 267747002997 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 267747002998 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 267747002999 domain; Region: Glyco_hydro_2; pfam00703 267747003000 Helix-turn-helix domains; Region: HTH; cl00088 267747003001 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747003002 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 267747003003 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747003004 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747003005 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 267747003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003007 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747003008 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 267747003009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267747003010 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 267747003011 anchoring element; other site 267747003012 dimer interface [polypeptide binding]; other site 267747003013 ATP binding site [chemical binding]; other site 267747003014 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 267747003015 active site 267747003016 metal binding site [ion binding]; metal-binding site 267747003017 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 267747003018 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 267747003019 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 267747003020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747003021 putative substrate translocation pore; other site 267747003022 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 267747003023 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 267747003024 CAP-like domain; other site 267747003025 active site 267747003026 primary dimer interface [polypeptide binding]; other site 267747003027 Uncharacterized conserved protein [Function unknown]; Region: COG4850 267747003028 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 267747003029 Sulfatase; Region: Sulfatase; cl10460 267747003030 Thymidine kinase; Region: TK; cl00631 267747003031 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 267747003032 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 267747003033 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 267747003034 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 267747003035 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 267747003036 trimer interface [polypeptide binding]; other site 267747003037 active site 267747003038 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 267747003039 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 267747003040 generic binding surface II; other site 267747003041 ssDNA binding site; other site 267747003042 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 267747003043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003044 NAD(P) binding site [chemical binding]; other site 267747003045 active site 267747003046 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 267747003047 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 267747003048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003049 Amino acid permease; Region: AA_permease; cl00524 267747003050 TRAM domain; Region: TRAM; cl01282 267747003051 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 267747003052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747003053 aconitate hydratase; Validated; Region: PRK09277 267747003054 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 267747003055 substrate binding site [chemical binding]; other site 267747003056 ligand binding site [chemical binding]; other site 267747003057 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 267747003058 substrate binding site [chemical binding]; other site 267747003059 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 267747003060 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 267747003061 TPP-binding site; other site 267747003062 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 267747003063 PYR/PP interface [polypeptide binding]; other site 267747003064 dimer interface [polypeptide binding]; other site 267747003065 TPP binding site [chemical binding]; other site 267747003066 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267747003067 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 267747003068 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 267747003069 putative active site [active] 267747003070 catalytic site [active] 267747003071 putative substrate binding site [chemical binding]; other site 267747003072 HRDC domain; Region: HRDC; cl02578 267747003073 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 267747003074 SelR domain; Region: SelR; cl00369 267747003075 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 267747003076 active site 267747003077 YheO-like PAS domain; Region: PAS_6; pfam08348 267747003078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 267747003079 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 267747003080 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267747003081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267747003082 catalytic residue [active] 267747003083 Amino acid permease; Region: AA_permease; cl00524 267747003084 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747003085 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 267747003086 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 267747003087 putative NAD(P) binding site [chemical binding]; other site 267747003088 putative substrate binding site [chemical binding]; other site 267747003089 catalytic Zn binding site [ion binding]; other site 267747003090 structural Zn binding site [ion binding]; other site 267747003091 dimer interface [polypeptide binding]; other site 267747003092 LrgB-like family; Region: LrgB; cl00596 267747003093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267747003094 Histidine kinase; Region: HisKA_3; pfam07730 267747003095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747003096 ATP binding site [chemical binding]; other site 267747003097 Mg2+ binding site [ion binding]; other site 267747003098 G-X-G motif; other site 267747003099 Ubiquitin-like proteins; Region: UBQ; cl00155 267747003100 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 267747003101 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 267747003102 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 267747003103 active site 267747003104 dimer interface [polypeptide binding]; other site 267747003105 motif 1; other site 267747003106 motif 2; other site 267747003107 motif 3; other site 267747003108 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 267747003109 anticodon binding site; other site 267747003110 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 267747003111 nucleotide binding site/active site [active] 267747003112 HIT family signature motif; other site 267747003113 catalytic residue [active] 267747003114 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 267747003115 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 267747003116 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 267747003117 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 267747003118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 267747003119 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 267747003120 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 267747003121 lipoyl attachment site [posttranslational modification]; other site 267747003122 Double zinc ribbon; Region: DZR; pfam12773 267747003123 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 267747003124 phosphopeptide binding site; other site 267747003125 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 267747003126 DNA binding residues [nucleotide binding] 267747003127 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 267747003128 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 267747003129 DNA binding residues [nucleotide binding] 267747003130 putative dimer interface [polypeptide binding]; other site 267747003131 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 267747003132 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 267747003133 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 267747003134 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 267747003135 active site 267747003136 ADP/pyrophosphate binding site [chemical binding]; other site 267747003137 allosteric effector site; other site 267747003138 fructose-1,6-bisphosphate binding site; other site 267747003139 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 267747003140 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 267747003141 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 267747003142 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 267747003143 Uncharacterized conserved protein [Function unknown]; Region: COG1739 267747003144 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 267747003145 Predicted membrane protein [Function unknown]; Region: COG1289 267747003146 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 267747003147 PAC2 family; Region: PAC2; cl00847 267747003148 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 267747003149 active site 267747003150 acyl-CoA esterase; Provisional; Region: PRK10673 267747003151 Protein of unknown function DUF91; Region: DUF91; cl00709 267747003152 DivIVA protein; Region: DivIVA; pfam05103 267747003153 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 267747003154 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 267747003155 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 267747003156 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 267747003157 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267747003158 dimer interface [polypeptide binding]; other site 267747003159 substrate binding site [chemical binding]; other site 267747003160 metal binding site [ion binding]; metal-binding site 267747003161 phosphoglucomutase; Validated; Region: PRK07564 267747003162 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 267747003163 active site 267747003164 substrate binding site [chemical binding]; other site 267747003165 metal binding site [ion binding]; metal-binding site 267747003166 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 267747003167 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 267747003168 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747003169 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 267747003170 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 267747003171 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 267747003172 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 267747003173 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 267747003174 active site turn [active] 267747003175 phosphorylation site [posttranslational modification] 267747003176 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747003177 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 267747003178 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 267747003179 HPr interaction site; other site 267747003180 glycerol kinase (GK) interaction site [polypeptide binding]; other site 267747003181 active site 267747003182 phosphorylation site [posttranslational modification] 267747003183 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 267747003184 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 267747003185 nudix motif; other site 267747003186 glycogen branching enzyme; Provisional; Region: PRK12313 267747003187 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 267747003188 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 267747003189 active site 267747003190 catalytic site [active] 267747003191 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 267747003192 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 267747003193 trehalose synthase; Region: treS_nterm; TIGR02456 267747003194 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 267747003195 active site 267747003196 catalytic site [active] 267747003197 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 267747003198 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 267747003199 active site 267747003200 homodimer interface [polypeptide binding]; other site 267747003201 catalytic site [active] 267747003202 acceptor binding site [chemical binding]; other site 267747003203 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 267747003204 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 267747003205 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 267747003206 active site 267747003207 catalytic site [active] 267747003208 Aminotransferase class-V; Region: Aminotran_5; pfam00266 267747003209 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267747003210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267747003211 catalytic residue [active] 267747003212 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 267747003213 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 267747003214 Ligand Binding Site [chemical binding]; other site 267747003215 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 267747003216 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 267747003217 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 267747003218 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 267747003219 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 267747003220 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 267747003221 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 267747003222 GatB domain; Region: GatB_Yqey; cl11497 267747003223 TIGR03085 family protein; Region: TIGR03085 267747003224 DinB superfamily; Region: DinB_2; cl00986 267747003225 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 267747003226 anthranilate synthase component I; Provisional; Region: PRK13571 267747003227 anthranilate synthase component I; Provisional; Region: PRK13571 267747003228 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759 267747003229 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 267747003230 active site 267747003231 ribulose/triose binding site [chemical binding]; other site 267747003232 phosphate binding site [ion binding]; other site 267747003233 substrate (anthranilate) binding pocket [chemical binding]; other site 267747003234 product (indole) binding pocket [chemical binding]; other site 267747003235 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 267747003236 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 267747003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747003238 catalytic residue [active] 267747003239 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 267747003240 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 267747003241 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 267747003242 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 267747003243 active site 267747003244 dimer interface [polypeptide binding]; other site 267747003245 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 267747003246 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 267747003247 active site 267747003248 FMN binding site [chemical binding]; other site 267747003249 substrate binding site [chemical binding]; other site 267747003250 3Fe-4S cluster binding site [ion binding]; other site 267747003251 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 267747003252 domain interface; other site 267747003253 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 267747003254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003255 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747003256 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 267747003257 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 267747003258 putative active site [active] 267747003259 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 267747003260 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 267747003261 putative active site [active] 267747003262 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 267747003263 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 267747003264 active site turn [active] 267747003265 phosphorylation site [posttranslational modification] 267747003266 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747003267 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 267747003268 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747003269 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 267747003270 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 267747003271 active site 267747003272 P-loop; other site 267747003273 phosphorylation site [posttranslational modification] 267747003274 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747003275 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 267747003276 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 267747003277 methionine cluster; other site 267747003278 active site 267747003279 phosphorylation site [posttranslational modification] 267747003280 metal binding site [ion binding]; metal-binding site 267747003281 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 267747003282 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 267747003283 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 267747003284 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 267747003285 generic binding surface II; other site 267747003286 generic binding surface I; other site 267747003287 histidinol dehydrogenase; Region: hisD; TIGR00069 267747003288 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 267747003289 NAD binding site [chemical binding]; other site 267747003290 dimerization interface [polypeptide binding]; other site 267747003291 product binding site; other site 267747003292 substrate binding site [chemical binding]; other site 267747003293 zinc binding site [ion binding]; other site 267747003294 catalytic residues [active] 267747003295 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 267747003296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747003297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747003298 homodimer interface [polypeptide binding]; other site 267747003299 catalytic residue [active] 267747003300 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 267747003301 putative active site pocket [active] 267747003302 4-fold oligomerization interface [polypeptide binding]; other site 267747003303 metal binding residues [ion binding]; metal-binding site 267747003304 3-fold/trimer interface [polypeptide binding]; other site 267747003305 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 267747003306 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 267747003307 putative active site [active] 267747003308 oxyanion strand; other site 267747003309 catalytic triad [active] 267747003310 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 267747003311 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 267747003312 catalytic residues [active] 267747003313 Domain of unknown function DUF28; Region: DUF28; cl00361 267747003314 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 267747003315 active site 267747003316 putative DNA-binding cleft [nucleotide binding]; other site 267747003317 dimer interface [polypeptide binding]; other site 267747003318 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 267747003319 RuvA N terminal domain; Region: RuvA_N; pfam01330 267747003320 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 267747003321 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 267747003322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747003323 Walker A motif; other site 267747003324 ATP binding site [chemical binding]; other site 267747003325 Walker B motif; other site 267747003326 arginine finger; other site 267747003327 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 267747003328 Preprotein translocase subunit; Region: YajC; cl00806 267747003329 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 267747003330 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 267747003331 Protein export membrane protein; Region: SecD_SecF; cl14618 267747003332 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 267747003333 Protein export membrane protein; Region: SecD_SecF; cl14618 267747003334 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747003335 Ion channel; Region: Ion_trans_2; cl11596 267747003336 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 267747003337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003338 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 267747003339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267747003340 Zn2+ binding site [ion binding]; other site 267747003341 Mg2+ binding site [ion binding]; other site 267747003342 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 267747003343 synthetase active site [active] 267747003344 NTP binding site [chemical binding]; other site 267747003345 metal binding site [ion binding]; metal-binding site 267747003346 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 267747003347 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 267747003348 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 267747003349 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 267747003350 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 267747003351 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267747003352 histidyl-tRNA synthetase; Region: hisS; TIGR00442 267747003353 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 267747003354 dimer interface [polypeptide binding]; other site 267747003355 motif 1; other site 267747003356 active site 267747003357 motif 2; other site 267747003358 motif 3; other site 267747003359 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 267747003360 anticodon binding site; other site 267747003361 Protein of unknown function (DUF998); Region: DUF998; pfam06197 267747003362 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 267747003363 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747003364 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747003365 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 267747003366 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747003367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 267747003368 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; pfam09989 267747003369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 267747003370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747003371 Helix-turn-helix domains; Region: HTH; cl00088 267747003372 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 267747003373 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 267747003374 dimer interface [polypeptide binding]; other site 267747003375 anticodon binding site; other site 267747003376 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 267747003377 homodimer interface [polypeptide binding]; other site 267747003378 motif 1; other site 267747003379 active site 267747003380 motif 2; other site 267747003381 GAD domain; Region: GAD; pfam02938 267747003382 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 267747003383 active site 267747003384 motif 3; other site 267747003385 recombination factor protein RarA; Reviewed; Region: PRK13342 267747003386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747003387 Walker A motif; other site 267747003388 ATP binding site [chemical binding]; other site 267747003389 Walker B motif; other site 267747003390 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 267747003391 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 267747003392 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 267747003393 motif 1; other site 267747003394 active site 267747003395 motif 2; other site 267747003396 motif 3; other site 267747003397 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 267747003398 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 267747003399 YceG-like family; Region: YceG; pfam02618 267747003400 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 267747003401 dimerization interface [polypeptide binding]; other site 267747003402 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 267747003403 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 267747003404 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 267747003405 shikimate binding site; other site 267747003406 NAD(P) binding site [chemical binding]; other site 267747003407 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 267747003408 Tetramer interface [polypeptide binding]; other site 267747003409 active site 267747003410 FMN-binding site [chemical binding]; other site 267747003411 shikimate kinase; Reviewed; Region: aroK; PRK00131 267747003412 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 267747003413 ADP binding site [chemical binding]; other site 267747003414 magnesium binding site [ion binding]; other site 267747003415 putative shikimate binding site; other site 267747003416 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 267747003417 dimer interface [polypeptide binding]; other site 267747003418 active site 267747003419 metal binding site [ion binding]; metal-binding site 267747003420 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 267747003421 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 267747003422 putative active site [active] 267747003423 putative metal binding site [ion binding]; other site 267747003424 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 267747003425 elongation factor P; Validated; Region: PRK00529 267747003426 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 267747003427 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 267747003428 RNA binding site [nucleotide binding]; other site 267747003429 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 267747003430 RNA binding site [nucleotide binding]; other site 267747003431 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 267747003432 putative RNA binding site [nucleotide binding]; other site 267747003433 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 267747003434 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 267747003435 catalytic site [active] 267747003436 G-X2-G-X-G-K; other site 267747003437 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 267747003438 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 267747003439 Flavoprotein; Region: Flavoprotein; cl08021 267747003440 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 267747003441 S-adenosylmethionine synthetase; Validated; Region: PRK05250 267747003442 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 267747003443 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 267747003444 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 267747003445 primosome assembly protein PriA; Provisional; Region: PRK14873 267747003446 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 267747003447 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 267747003448 putative active site [active] 267747003449 substrate binding site [chemical binding]; other site 267747003450 putative cosubstrate binding site; other site 267747003451 catalytic site [active] 267747003452 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 267747003453 substrate binding site [chemical binding]; other site 267747003454 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 267747003455 putative RNA binding site [nucleotide binding]; other site 267747003456 16S rRNA methyltransferase B; Provisional; Region: PRK14902 267747003457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747003458 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 267747003459 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 267747003460 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 267747003461 substrate binding site [chemical binding]; other site 267747003462 hexamer interface [polypeptide binding]; other site 267747003463 metal binding site [ion binding]; metal-binding site 267747003464 PAC2 family; Region: PAC2; cl00847 267747003465 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 267747003466 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 267747003467 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747003468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747003469 motif II; other site 267747003470 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 267747003471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747003472 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 267747003473 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 267747003474 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 267747003475 ABC-2 type transporter; Region: ABC2_membrane; cl11417 267747003476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003477 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 267747003478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747003479 Helix-turn-helix domains; Region: HTH; cl00088 267747003480 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 267747003481 active site 267747003482 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 267747003483 prephenate dehydrogenase; Validated; Region: PRK06545 267747003484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003485 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 267747003486 cytidylate kinase; Provisional; Region: cmk; PRK00023 267747003487 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 267747003488 CMP-binding site; other site 267747003489 GTP-binding protein Der; Reviewed; Region: PRK03003 267747003490 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 267747003491 G1 box; other site 267747003492 GTP/Mg2+ binding site [chemical binding]; other site 267747003493 Switch I region; other site 267747003494 G2 box; other site 267747003495 Switch II region; other site 267747003496 G3 box; other site 267747003497 G4 box; other site 267747003498 G5 box; other site 267747003499 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 267747003500 G1 box; other site 267747003501 GTP/Mg2+ binding site [chemical binding]; other site 267747003502 Switch I region; other site 267747003503 G2 box; other site 267747003504 G3 box; other site 267747003505 Switch II region; other site 267747003506 G4 box; other site 267747003507 G5 box; other site 267747003508 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267747003509 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 267747003510 substrate binding site [chemical binding]; other site 267747003511 dimer interface [polypeptide binding]; other site 267747003512 ATP binding site [chemical binding]; other site 267747003513 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 267747003514 active site 267747003515 catalytic residues [active] 267747003516 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 267747003517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747003518 putative substrate translocation pore; other site 267747003519 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 267747003520 intersubunit interface [polypeptide binding]; other site 267747003521 active site 267747003522 catalytic residue [active] 267747003523 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 267747003524 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 267747003525 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 267747003526 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747003527 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747003528 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 267747003529 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 267747003530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747003531 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 267747003532 Helix-turn-helix domains; Region: HTH; cl00088 267747003533 Helix-turn-helix domains; Region: HTH; cl00088 267747003534 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 267747003535 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 267747003536 putative active site [active] 267747003537 catalytic triad [active] 267747003538 putative dimer interface [polypeptide binding]; other site 267747003539 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 267747003540 Ligand binding site; other site 267747003541 Putative Catalytic site; other site 267747003542 DXD motif; other site 267747003543 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 267747003544 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 267747003545 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 267747003546 putative active site [active] 267747003547 putative metal binding site [ion binding]; other site 267747003548 catalytic site [active] 267747003549 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 267747003550 dimer interface [polypeptide binding]; other site 267747003551 pyridoxal binding site [chemical binding]; other site 267747003552 ATP binding site [chemical binding]; other site 267747003553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267747003554 non-specific DNA binding site [nucleotide binding]; other site 267747003555 salt bridge; other site 267747003556 sequence-specific DNA binding site [nucleotide binding]; other site 267747003557 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 267747003558 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 267747003559 putative active site [active] 267747003560 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 267747003561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003563 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267747003564 Cation efflux family; Region: Cation_efflux; cl00316 267747003565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267747003566 dimerization interface [polypeptide binding]; other site 267747003567 putative DNA binding site [nucleotide binding]; other site 267747003568 putative Zn2+ binding site [ion binding]; other site 267747003569 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 267747003570 RF-1 domain; Region: RF-1; cl02875 267747003571 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 267747003572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747003573 putative substrate translocation pore; other site 267747003574 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 267747003575 Fe-S cluster binding site [ion binding]; other site 267747003576 DNA binding site [nucleotide binding] 267747003577 active site 267747003578 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 267747003579 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 267747003580 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 267747003581 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 267747003582 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 267747003583 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 267747003584 alpha subunit interaction interface [polypeptide binding]; other site 267747003585 Walker A motif; other site 267747003586 ATP binding site [chemical binding]; other site 267747003587 Walker B motif; other site 267747003588 inhibitor binding site; inhibition site 267747003589 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 267747003590 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 267747003591 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 267747003592 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 267747003593 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 267747003594 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 267747003595 beta subunit interaction interface [polypeptide binding]; other site 267747003596 Walker A motif; other site 267747003597 ATP binding site [chemical binding]; other site 267747003598 Walker B motif; other site 267747003599 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 267747003600 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 267747003601 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 267747003602 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 267747003603 ATP synthase subunit C; Region: ATP-synt_C; cl00466 267747003604 ATP synthase A chain; Region: ATP-synt_A; cl00413 267747003605 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 267747003606 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 267747003607 putative catalytic motif [active] 267747003608 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 267747003609 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 267747003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747003611 S-adenosylmethionine binding site [chemical binding]; other site 267747003612 peptide chain release factor 1; Validated; Region: prfA; PRK00591 267747003613 RF-1 domain; Region: RF-1; cl02875 267747003614 RF-1 domain; Region: RF-1; cl02875 267747003615 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 267747003616 transcription termination factor Rho; Provisional; Region: PRK12678 267747003617 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 267747003618 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 267747003619 RNA binding site [nucleotide binding]; other site 267747003620 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003621 Walker A motif; other site 267747003622 ATP binding site [chemical binding]; other site 267747003623 Walker B motif; other site 267747003624 homoserine kinase; Provisional; Region: PRK01212 267747003625 threonine synthase; Reviewed; Region: PRK06721 267747003626 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 267747003627 homodimer interface [polypeptide binding]; other site 267747003628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747003629 catalytic residue [active] 267747003630 homoserine dehydrogenase; Provisional; Region: PRK06349 267747003631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003632 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 267747003633 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 267747003634 diaminopimelate decarboxylase; Region: lysA; TIGR01048 267747003635 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 267747003636 active site 267747003637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267747003638 substrate binding site [chemical binding]; other site 267747003639 catalytic residues [active] 267747003640 dimer interface [polypeptide binding]; other site 267747003641 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 267747003642 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 267747003643 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 267747003644 TPP-binding site [chemical binding]; other site 267747003645 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 267747003646 Transcription factor WhiB; Region: Whib; pfam02467 267747003647 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 267747003648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267747003649 Histidine kinase; Region: HisKA_2; cl06527 267747003650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267747003651 Anti-sigma-K factor rskA; Region: RskA; cl15366 267747003652 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 267747003653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267747003654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267747003655 DNA binding residues [nucleotide binding] 267747003656 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 267747003657 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 267747003658 hinge; other site 267747003659 active site 267747003660 Predicted GTPases [General function prediction only]; Region: COG1162 267747003661 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 267747003662 GTPase/OB domain interface [polypeptide binding]; other site 267747003663 GTPase/Zn-binding domain interface [polypeptide binding]; other site 267747003664 GTP/Mg2+ binding site [chemical binding]; other site 267747003665 G4 box; other site 267747003666 G5 box; other site 267747003667 G1 box; other site 267747003668 Switch I region; other site 267747003669 G2 box; other site 267747003670 G3 box; other site 267747003671 Switch II region; other site 267747003672 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 267747003673 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 267747003674 active site 267747003675 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 267747003676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003677 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 267747003678 L-serine binding site [chemical binding]; other site 267747003679 ACT domain interface; other site 267747003680 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 267747003681 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 267747003682 Walker A/P-loop; other site 267747003683 ATP binding site [chemical binding]; other site 267747003684 Q-loop/lid; other site 267747003685 ABC transporter signature motif; other site 267747003686 Walker B; other site 267747003687 D-loop; other site 267747003688 H-loop/switch region; other site 267747003689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 267747003690 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 267747003691 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 267747003692 Walker A/P-loop; other site 267747003693 ATP binding site [chemical binding]; other site 267747003694 Q-loop/lid; other site 267747003695 ABC transporter signature motif; other site 267747003696 Walker B; other site 267747003697 D-loop; other site 267747003698 H-loop/switch region; other site 267747003699 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 267747003700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747003701 dimer interface [polypeptide binding]; other site 267747003702 conserved gate region; other site 267747003703 putative PBP binding loops; other site 267747003704 ABC-ATPase subunit interface; other site 267747003705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 267747003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747003707 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 267747003708 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 267747003709 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267747003710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003711 Magnesium ion binding site [ion binding]; other site 267747003712 Domain of unknown function (DUF929); Region: DUF929; pfam06053 267747003713 argininosuccinate lyase; Provisional; Region: PRK02186 267747003714 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747003715 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 267747003716 AMP-binding enzyme; Region: AMP-binding; pfam00501 267747003717 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747003718 Phosphopantetheine attachment site; Region: PP-binding; cl09936 267747003719 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747003720 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 267747003721 peptide synthase; Validated; Region: PRK05691 267747003722 Phosphopantetheine attachment site; Region: PP-binding; cl09936 267747003723 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 267747003724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003725 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 267747003726 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 267747003727 dimer interface [polypeptide binding]; other site 267747003728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747003729 catalytic residue [active] 267747003730 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 267747003731 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 267747003732 ParB-like nuclease domain; Region: ParBc; cl02129 267747003733 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747003734 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 267747003735 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 267747003736 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 267747003737 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 267747003738 Ligand Binding Site [chemical binding]; other site 267747003739 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 267747003740 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267747003741 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 267747003742 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 267747003743 Protein of unknown function DUF45; Region: DUF45; cl00636 267747003744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003745 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 267747003746 HRDC domain; Region: HRDC; cl02578 267747003747 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 267747003748 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 267747003749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003750 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 267747003751 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 267747003752 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 267747003753 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 267747003754 putative NADH binding site [chemical binding]; other site 267747003755 putative active site [active] 267747003756 nudix motif; other site 267747003757 putative metal binding site [ion binding]; other site 267747003758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003759 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 267747003760 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 267747003761 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 267747003762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003763 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 267747003764 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 267747003765 active site 267747003766 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 267747003767 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 267747003768 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 267747003769 ATP binding site [chemical binding]; other site 267747003770 Mg++ binding site [ion binding]; other site 267747003771 motif III; other site 267747003772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747003773 nucleotide binding region [chemical binding]; other site 267747003774 ATP-binding site [chemical binding]; other site 267747003775 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747003776 Amino acid permease; Region: AA_permease; cl00524 267747003777 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 267747003778 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 267747003779 active site 267747003780 HIGH motif; other site 267747003781 dimer interface [polypeptide binding]; other site 267747003782 KMSKS motif; other site 267747003783 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 267747003784 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 267747003785 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 267747003786 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 267747003787 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 267747003788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003789 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 267747003790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003791 nucleotide binding region [chemical binding]; other site 267747003792 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 267747003793 30S subunit binding site; other site 267747003794 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 267747003795 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747003796 lipoprotein LpqB; Provisional; Region: PRK13615 267747003797 Sporulation and spore germination; Region: Germane; cl11253 267747003798 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 267747003799 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 267747003800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267747003801 dimerization interface [polypeptide binding]; other site 267747003802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267747003803 dimer interface [polypeptide binding]; other site 267747003804 phosphorylation site [posttranslational modification] 267747003805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747003806 ATP binding site [chemical binding]; other site 267747003807 Mg2+ binding site [ion binding]; other site 267747003808 G-X-G motif; other site 267747003809 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267747003810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747003811 active site 267747003812 phosphorylation site [posttranslational modification] 267747003813 intermolecular recognition site; other site 267747003814 dimerization interface [polypeptide binding]; other site 267747003815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267747003816 DNA binding site [nucleotide binding] 267747003817 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 267747003818 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 267747003819 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 267747003820 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 267747003821 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 267747003822 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 267747003823 argininosuccinate lyase; Provisional; Region: PRK00855 267747003824 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 267747003825 active sites [active] 267747003826 tetramer interface [polypeptide binding]; other site 267747003827 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 267747003828 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 267747003829 inhibitor-cofactor binding pocket; inhibition site 267747003830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747003831 catalytic residue [active] 267747003832 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 267747003833 feedback inhibition sensing region; other site 267747003834 homohexameric interface [polypeptide binding]; other site 267747003835 nucleotide binding site [chemical binding]; other site 267747003836 N-acetyl-L-glutamate binding site [chemical binding]; other site 267747003837 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 267747003838 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 267747003839 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 267747003840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003841 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 267747003842 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 267747003843 SmpB-tmRNA interface; other site 267747003844 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 267747003845 FtsX-like permease family; Region: FtsX; pfam02687 267747003846 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 267747003847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003848 Walker A/P-loop; other site 267747003849 ATP binding site [chemical binding]; other site 267747003850 Q-loop/lid; other site 267747003851 ABC transporter signature motif; other site 267747003852 Walker B; other site 267747003853 D-loop; other site 267747003854 H-loop/switch region; other site 267747003855 peptide chain release factor 2; Validated; Region: prfB; PRK00578 267747003856 RF-1 domain; Region: RF-1; cl02875 267747003857 RF-1 domain; Region: RF-1; cl02875 267747003858 Protein of unknown function (DUF805); Region: DUF805; cl01224 267747003859 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 267747003860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747003861 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 267747003862 thiamine monophosphate kinase; Provisional; Region: PRK05731 267747003863 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 267747003864 ATP binding site [chemical binding]; other site 267747003865 dimerization interface [polypeptide binding]; other site 267747003866 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 267747003867 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 267747003868 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 267747003869 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747003870 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267747003871 putative acyl-acceptor binding pocket; other site 267747003872 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 267747003873 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 267747003874 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 267747003875 Transcriptional regulator [Transcription]; Region: IclR; COG1414 267747003876 Helix-turn-helix domains; Region: HTH; cl00088 267747003877 Bacterial transcriptional regulator; Region: IclR; pfam01614 267747003878 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 267747003879 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 267747003880 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 267747003881 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 267747003882 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 267747003883 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 267747003884 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 267747003885 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 267747003886 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 267747003887 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 267747003888 homodimer interface [polypeptide binding]; other site 267747003889 substrate-cofactor binding pocket; other site 267747003890 catalytic residue [active] 267747003891 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 267747003892 ketol-acid reductoisomerase; Provisional; Region: PRK05479 267747003893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747003894 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 267747003895 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 267747003896 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 267747003897 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 267747003898 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 267747003899 HIT family signature motif; other site 267747003900 catalytic residue [active] 267747003901 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 267747003902 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 267747003903 substrate binding site [chemical binding]; other site 267747003904 glutamase interaction surface [polypeptide binding]; other site 267747003905 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 267747003906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747003907 ATP binding site [chemical binding]; other site 267747003908 putative Mg++ binding site [ion binding]; other site 267747003909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747003910 nucleotide binding region [chemical binding]; other site 267747003911 ATP-binding site [chemical binding]; other site 267747003912 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 267747003913 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 267747003914 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 267747003915 Predicted transcriptional regulator [Transcription]; Region: COG2378 267747003916 Predicted transcriptional regulator [Transcription]; Region: COG2378 267747003917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747003918 active site 267747003919 HIGH motif; other site 267747003920 nucleotide binding site [chemical binding]; other site 267747003921 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747003922 active site 267747003923 KMSKS motif; other site 267747003924 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 267747003925 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 267747003926 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 267747003927 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267747003928 RNA binding surface [nucleotide binding]; other site 267747003929 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 267747003930 active site 267747003931 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 267747003932 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267747003933 P-loop; other site 267747003934 Magnesium ion binding site [ion binding]; other site 267747003935 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267747003936 Magnesium ion binding site [ion binding]; other site 267747003937 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 267747003938 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 267747003939 Int/Topo IB signature motif; other site 267747003940 active site 267747003941 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 267747003942 dimer interface [polypeptide binding]; other site 267747003943 ADP-ribose binding site [chemical binding]; other site 267747003944 active site 267747003945 nudix motif; other site 267747003946 metal binding site [ion binding]; metal-binding site 267747003947 CTP synthetase; Validated; Region: pyrG; PRK05380 267747003948 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 267747003949 Catalytic site [active] 267747003950 active site 267747003951 UTP binding site [chemical binding]; other site 267747003952 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 267747003953 active site 267747003954 putative oxyanion hole; other site 267747003955 catalytic triad [active] 267747003956 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 267747003957 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 267747003958 Walker A/P-loop; other site 267747003959 ATP binding site [chemical binding]; other site 267747003960 Q-loop/lid; other site 267747003961 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 267747003962 ABC transporter signature motif; other site 267747003963 Walker B; other site 267747003964 D-loop; other site 267747003965 H-loop/switch region; other site 267747003966 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 267747003967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267747003968 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 267747003969 RNA binding surface [nucleotide binding]; other site 267747003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747003971 Cobalt transport protein; Region: CbiQ; cl00463 267747003972 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747003973 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 267747003974 Walker A/P-loop; other site 267747003975 ATP binding site [chemical binding]; other site 267747003976 Q-loop/lid; other site 267747003977 ABC transporter signature motif; other site 267747003978 Walker B; other site 267747003979 D-loop; other site 267747003980 H-loop/switch region; other site 267747003981 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 267747003982 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 267747003983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747003984 active site 267747003985 motif I; other site 267747003986 motif II; other site 267747003987 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 267747003988 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 267747003989 active site 267747003990 HIGH motif; other site 267747003991 dimer interface [polypeptide binding]; other site 267747003992 KMSKS motif; other site 267747003993 arginine repressor; Provisional; Region: PRK03341 267747003994 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 267747003995 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 267747003996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747003997 Helix-turn-helix domains; Region: HTH; cl00088 267747003998 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 267747003999 biotin synthase; Validated; Region: PRK06256 267747004000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747004001 FeS/SAM binding site; other site 267747004002 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 267747004003 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 267747004004 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 267747004005 putative tRNA-binding site [nucleotide binding]; other site 267747004006 B3/4 domain; Region: B3_4; cl11458 267747004007 tRNA synthetase B5 domain; Region: B5; cl08394 267747004008 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 267747004009 dimer interface [polypeptide binding]; other site 267747004010 motif 1; other site 267747004011 motif 3; other site 267747004012 motif 2; other site 267747004013 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 267747004014 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 267747004015 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 267747004016 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 267747004017 dimer interface [polypeptide binding]; other site 267747004018 motif 1; other site 267747004019 active site 267747004020 motif 2; other site 267747004021 motif 3; other site 267747004022 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 267747004023 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 267747004024 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 267747004025 ribosomal protein L20; Region: rpl20; CHL00068 267747004026 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 267747004027 23S rRNA binding site [nucleotide binding]; other site 267747004028 L21 binding site [polypeptide binding]; other site 267747004029 L13 binding site [polypeptide binding]; other site 267747004030 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 267747004031 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 267747004032 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 267747004033 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 267747004034 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 267747004035 ATP phosphoribosyltransferase; Region: HisG; cl15266 267747004036 HisG, C-terminal domain; Region: HisG_C; cl06867 267747004037 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 267747004038 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 267747004039 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 267747004040 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 267747004041 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 267747004042 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267747004043 active site 267747004044 catalytic tetrad [active] 267747004045 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 267747004046 dimer interface [polypeptide binding]; other site 267747004047 Citrate synthase; Region: Citrate_synt; pfam00285 267747004048 active site 267747004049 citrylCoA binding site [chemical binding]; other site 267747004050 NADH binding [chemical binding]; other site 267747004051 cationic pore residues; other site 267747004052 oxalacetate/citrate binding site [chemical binding]; other site 267747004053 coenzyme A binding site [chemical binding]; other site 267747004054 catalytic triad [active] 267747004055 hypothetical protein; Provisional; Region: PRK07906 267747004056 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 267747004057 putative metal binding site [ion binding]; other site 267747004058 acid shock protein precursor; Provisional; Region: PRK03577 267747004059 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 267747004060 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747004061 CsbD-like; Region: CsbD; cl01888 267747004062 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 267747004063 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 267747004064 DNA binding site [nucleotide binding] 267747004065 active site 267747004066 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 267747004067 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 267747004068 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 267747004069 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 267747004070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747004071 Walker A motif; other site 267747004072 ATP binding site [chemical binding]; other site 267747004073 Walker B motif; other site 267747004074 arginine finger; other site 267747004075 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 267747004076 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 267747004077 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 267747004078 RNA/DNA hybrid binding site [nucleotide binding]; other site 267747004079 active site 267747004080 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 267747004081 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 267747004082 Catalytic site [active] 267747004083 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 267747004084 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 267747004085 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 267747004086 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 267747004087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004088 domain; Region: Succ_DH_flav_C; pfam02910 267747004089 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 267747004090 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 267747004091 putative Iron-sulfur protein interface [polypeptide binding]; other site 267747004092 proximal heme binding site [chemical binding]; other site 267747004093 distal heme binding site [chemical binding]; other site 267747004094 putative dimer interface [polypeptide binding]; other site 267747004095 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 267747004096 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 267747004097 RimM N-terminal domain; Region: RimM; pfam01782 267747004098 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 267747004099 hypothetical protein; Provisional; Region: PRK00468; cl00794 267747004100 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 267747004101 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 267747004102 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 267747004103 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 267747004104 active site 267747004105 signal recognition particle protein; Provisional; Region: PRK10867 267747004106 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 267747004107 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 267747004108 P loop; other site 267747004109 GTP binding site [chemical binding]; other site 267747004110 Signal peptide binding domain; Region: SRP_SPB; pfam02978 267747004111 Predicted esterase [General function prediction only]; Region: COG0627 267747004112 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 267747004113 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 267747004114 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 267747004115 P loop; other site 267747004116 GTP binding site [chemical binding]; other site 267747004117 GtrA-like protein; Region: GtrA; cl00971 267747004118 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 267747004119 HicB family; Region: HicB; pfam05534 267747004120 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 267747004121 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 267747004122 DNA binding site [nucleotide binding] 267747004123 catalytic residue [active] 267747004124 H2TH interface [polypeptide binding]; other site 267747004125 putative catalytic residues [active] 267747004126 turnover-facilitating residue; other site 267747004127 intercalation triad [nucleotide binding]; other site 267747004128 8OG recognition residue [nucleotide binding]; other site 267747004129 putative reading head residues; other site 267747004130 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 267747004131 ribonuclease III; Reviewed; Region: rnc; PRK00102 267747004132 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 267747004133 dimerization interface [polypeptide binding]; other site 267747004134 active site 267747004135 metal binding site [ion binding]; metal-binding site 267747004136 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 267747004137 dsRNA binding site [nucleotide binding]; other site 267747004138 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 267747004139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747004140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747004141 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 267747004142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004143 dimer interface [polypeptide binding]; other site 267747004144 conserved gate region; other site 267747004145 putative PBP binding loops; other site 267747004146 ABC-ATPase subunit interface; other site 267747004147 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 267747004148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004149 dimer interface [polypeptide binding]; other site 267747004150 conserved gate region; other site 267747004151 putative PBP binding loops; other site 267747004152 ABC-ATPase subunit interface; other site 267747004153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747004154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747004155 DNA binding site [nucleotide binding] 267747004156 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 267747004157 ligand binding site [chemical binding]; other site 267747004158 dimerization interface [polypeptide binding]; other site 267747004159 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 267747004160 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 267747004161 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 267747004162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004163 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 267747004164 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 267747004165 active site 267747004166 (T/H)XGH motif; other site 267747004167 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 267747004168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747004169 S-adenosylmethionine binding site [chemical binding]; other site 267747004170 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 267747004171 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 267747004172 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 267747004173 ssDNA binding site; other site 267747004174 generic binding surface II; other site 267747004175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747004176 ATP binding site [chemical binding]; other site 267747004177 putative Mg++ binding site [ion binding]; other site 267747004178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747004179 nucleotide binding region [chemical binding]; other site 267747004180 ATP-binding site [chemical binding]; other site 267747004181 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 267747004182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267747004183 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 267747004184 pyruvate dehydrogenase; Provisional; Region: PRK06546 267747004185 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 267747004186 PYR/PP interface [polypeptide binding]; other site 267747004187 tetramer interface [polypeptide binding]; other site 267747004188 dimer interface [polypeptide binding]; other site 267747004189 TPP binding site [chemical binding]; other site 267747004190 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 267747004191 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 267747004192 TPP-binding site [chemical binding]; other site 267747004193 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 267747004194 dihydrodipicolinate reductase; Provisional; Region: PRK00048 267747004195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004196 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 267747004197 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 267747004198 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 267747004199 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 267747004200 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 267747004201 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 267747004202 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 267747004203 putative nucleic acid binding region [nucleotide binding]; other site 267747004204 G-X-X-G motif; other site 267747004205 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 267747004206 RNA binding site [nucleotide binding]; other site 267747004207 domain interface; other site 267747004208 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 267747004209 16S/18S rRNA binding site [nucleotide binding]; other site 267747004210 S13e-L30e interaction site [polypeptide binding]; other site 267747004211 25S rRNA binding site [nucleotide binding]; other site 267747004212 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 267747004213 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 267747004214 active site 267747004215 Riboflavin kinase; Region: Flavokinase; cl03312 267747004216 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 267747004217 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 267747004218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004219 dimer interface [polypeptide binding]; other site 267747004220 conserved gate region; other site 267747004221 ABC-ATPase subunit interface; other site 267747004222 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 267747004223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004224 Walker A/P-loop; other site 267747004225 ATP binding site [chemical binding]; other site 267747004226 Q-loop/lid; other site 267747004227 ABC transporter signature motif; other site 267747004228 Walker B; other site 267747004229 D-loop; other site 267747004230 H-loop/switch region; other site 267747004231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 267747004232 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 267747004233 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 267747004234 RNA binding site [nucleotide binding]; other site 267747004235 active site 267747004236 Cupin domain; Region: Cupin_2; cl09118 267747004237 Helix-turn-helix domains; Region: HTH; cl00088 267747004238 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 267747004239 Helix-turn-helix domains; Region: HTH; cl00088 267747004240 PRD domain; Region: PRD; cl15445 267747004241 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 267747004242 P-loop; other site 267747004243 active site 267747004244 phosphorylation site [posttranslational modification] 267747004245 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747004246 active site 267747004247 phosphorylation site [posttranslational modification] 267747004248 Glucitol operon activator protein (GutM); Region: GutM; cl01890 267747004249 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 267747004250 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 267747004251 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 267747004252 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 267747004253 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 267747004254 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 267747004255 dimerization domain swap beta strand [polypeptide binding]; other site 267747004256 regulatory protein interface [polypeptide binding]; other site 267747004257 active site 267747004258 regulatory phosphorylation site [posttranslational modification]; other site 267747004259 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 267747004260 active site 267747004261 metal binding site [ion binding]; metal-binding site 267747004262 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 267747004263 Ribosome-binding factor A; Region: RBFA; cl00542 267747004264 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747004265 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 267747004266 Walker A/P-loop; other site 267747004267 ATP binding site [chemical binding]; other site 267747004268 Q-loop/lid; other site 267747004269 ABC transporter signature motif; other site 267747004270 Walker B; other site 267747004271 D-loop; other site 267747004272 H-loop/switch region; other site 267747004273 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 267747004274 translation initiation factor IF-2; Region: IF-2; TIGR00487 267747004275 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 267747004276 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 267747004277 G1 box; other site 267747004278 putative GEF interaction site [polypeptide binding]; other site 267747004279 GTP/Mg2+ binding site [chemical binding]; other site 267747004280 Switch I region; other site 267747004281 G2 box; other site 267747004282 G3 box; other site 267747004283 Switch II region; other site 267747004284 G4 box; other site 267747004285 G5 box; other site 267747004286 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 267747004287 Translation-initiation factor 2; Region: IF-2; pfam11987 267747004288 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 267747004289 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 267747004290 NusA N-terminal domain; Region: NusA_N; pfam08529 267747004291 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 267747004292 RNA binding site [nucleotide binding]; other site 267747004293 homodimer interface [polypeptide binding]; other site 267747004294 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 267747004295 G-X-X-G motif; other site 267747004296 ribosome maturation protein RimP; Reviewed; Region: PRK00092 267747004297 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 267747004298 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 267747004299 Sm1 motif; other site 267747004300 D3 - B interaction site; other site 267747004301 D1 - D2 interaction site; other site 267747004302 Hfq - Hfq interaction site; other site 267747004303 RNA binding pocket [nucleotide binding]; other site 267747004304 Sm2 motif; other site 267747004305 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 267747004306 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 267747004307 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 267747004308 prolyl-tRNA synthetase; Provisional; Region: PRK09194 267747004309 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 267747004310 dimer interface [polypeptide binding]; other site 267747004311 motif 1; other site 267747004312 active site 267747004313 motif 2; other site 267747004314 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 267747004315 putative deacylase active site [active] 267747004316 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 267747004317 active site 267747004318 motif 3; other site 267747004319 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 267747004320 anticodon binding site; other site 267747004321 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 267747004322 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747004323 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 267747004324 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747004325 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747004326 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747004327 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 267747004328 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747004329 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 267747004330 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 267747004331 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747004332 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 267747004333 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 267747004334 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747004335 ABC-ATPase subunit interface; other site 267747004336 dimer interface [polypeptide binding]; other site 267747004337 putative PBP binding regions; other site 267747004338 Predicted acetyltransferase [General function prediction only]; Region: COG3393 267747004339 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747004340 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 267747004341 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 267747004342 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 267747004343 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 267747004344 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 267747004345 active site 267747004346 RIP metalloprotease RseP; Region: TIGR00054 267747004347 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 267747004348 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 267747004349 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 267747004350 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 267747004351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747004352 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 267747004353 glutamate dehydrogenase; Provisional; Region: PRK09414 267747004354 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 267747004355 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 267747004356 NAD(P) binding site [chemical binding]; other site 267747004357 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 267747004358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747004359 FeS/SAM binding site; other site 267747004360 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 267747004361 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 267747004362 ribosome recycling factor; Reviewed; Region: frr; PRK00083 267747004363 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 267747004364 hinge region; other site 267747004365 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 267747004366 putative nucleotide binding site [chemical binding]; other site 267747004367 uridine monophosphate binding site [chemical binding]; other site 267747004368 homohexameric interface [polypeptide binding]; other site 267747004369 elongation factor Ts; Provisional; Region: tsf; PRK09377 267747004370 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 267747004371 Elongation factor TS; Region: EF_TS; pfam00889 267747004372 Elongation factor TS; Region: EF_TS; pfam00889 267747004373 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 267747004374 rRNA interaction site [nucleotide binding]; other site 267747004375 S8 interaction site; other site 267747004376 putative laminin-1 binding site; other site 267747004377 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 267747004378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 267747004379 DNA binding site [nucleotide binding] 267747004380 Int/Topo IB signature motif; other site 267747004381 active site 267747004382 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 267747004383 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 267747004384 active site 267747004385 catalytic residues [active] 267747004386 metal binding site [ion binding]; metal-binding site 267747004387 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 267747004388 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 267747004389 Membrane transport protein; Region: Mem_trans; cl09117 267747004390 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 267747004391 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 267747004392 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 267747004393 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 267747004394 Walker A/P-loop; other site 267747004395 ATP binding site [chemical binding]; other site 267747004396 Q-loop/lid; other site 267747004397 ABC transporter signature motif; other site 267747004398 Walker B; other site 267747004399 D-loop; other site 267747004400 H-loop/switch region; other site 267747004401 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 267747004402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004403 NAD(P) binding site [chemical binding]; other site 267747004404 active site 267747004405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004406 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 267747004407 NAD(P) binding site [chemical binding]; other site 267747004408 active site 267747004409 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 267747004410 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 267747004411 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 267747004412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747004413 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267747004414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004415 Walker A/P-loop; other site 267747004416 ATP binding site [chemical binding]; other site 267747004417 Q-loop/lid; other site 267747004418 ABC transporter signature motif; other site 267747004419 Walker B; other site 267747004420 D-loop; other site 267747004421 H-loop/switch region; other site 267747004422 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 267747004423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267747004424 Coenzyme A binding pocket [chemical binding]; other site 267747004425 Domain of unknown function DUF59; Region: DUF59; cl00941 267747004426 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 267747004427 trimerization site [polypeptide binding]; other site 267747004428 active site 267747004429 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 267747004430 Aminotransferase class-V; Region: Aminotran_5; pfam00266 267747004431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267747004432 catalytic residue [active] 267747004433 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 267747004434 FeS assembly ATPase SufC; Region: sufC; TIGR01978 267747004435 Walker A/P-loop; other site 267747004436 ATP binding site [chemical binding]; other site 267747004437 Q-loop/lid; other site 267747004438 ABC transporter signature motif; other site 267747004439 Walker B; other site 267747004440 D-loop; other site 267747004441 H-loop/switch region; other site 267747004442 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 267747004443 [2Fe-2S] cluster binding site [ion binding]; other site 267747004444 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 267747004445 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 267747004446 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 267747004447 FeS assembly protein SufB; Region: sufB; TIGR01980 267747004448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267747004449 putative DNA binding site [nucleotide binding]; other site 267747004450 dimerization interface [polypeptide binding]; other site 267747004451 Predicted transcriptional regulator [Transcription]; Region: COG2345 267747004452 putative Zn2+ binding site [ion binding]; other site 267747004453 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 267747004454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747004455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004456 dimer interface [polypeptide binding]; other site 267747004457 conserved gate region; other site 267747004458 putative PBP binding loops; other site 267747004459 ABC-ATPase subunit interface; other site 267747004460 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 267747004461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004462 dimer interface [polypeptide binding]; other site 267747004463 conserved gate region; other site 267747004464 putative PBP binding loops; other site 267747004465 ABC-ATPase subunit interface; other site 267747004466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747004467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747004468 DNA binding site [nucleotide binding] 267747004469 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 267747004470 putative dimerization interface [polypeptide binding]; other site 267747004471 putative ligand binding site [chemical binding]; other site 267747004472 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 267747004473 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 267747004474 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747004475 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 267747004476 Walker A/P-loop; other site 267747004477 ATP binding site [chemical binding]; other site 267747004478 Q-loop/lid; other site 267747004479 ABC transporter signature motif; other site 267747004480 Walker B; other site 267747004481 D-loop; other site 267747004482 H-loop/switch region; other site 267747004483 ABC-2 type transporter; Region: ABC2_membrane; cl11417 267747004484 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 267747004485 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 267747004486 catalytic site [active] 267747004487 Asp-box motif; other site 267747004488 UbiA prenyltransferase family; Region: UbiA; cl00337 267747004489 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 267747004490 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 267747004491 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 267747004492 opcA protein; Region: OpcA; TIGR00534 267747004493 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 267747004494 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 267747004495 putative active site [active] 267747004496 DoxX; Region: DoxX; cl00976 267747004497 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 267747004498 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 267747004499 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 267747004500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747004501 active site 267747004502 HIGH motif; other site 267747004503 nucleotide binding site [chemical binding]; other site 267747004504 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747004505 active site 267747004506 KMSKS motif; other site 267747004507 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 267747004508 tRNA binding surface [nucleotide binding]; other site 267747004509 anticodon binding site; other site 267747004510 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 267747004511 Endo-alpha-N-acetylgalactosaminidase glycoside hydrolase; Region: Glyco_hydro_100; pfam12899 267747004512 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 267747004513 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 267747004514 Orbivirus outer capsid protein VP2; Region: Orbi_VP2; pfam00898 267747004515 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 267747004516 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 267747004517 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 267747004518 protein binding site [polypeptide binding]; other site 267747004519 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 267747004520 Domain interface; other site 267747004521 Peptide binding site; other site 267747004522 Active site tetrad [active] 267747004523 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 267747004524 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 267747004525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747004526 Walker A motif; other site 267747004527 ATP binding site [chemical binding]; other site 267747004528 Walker B motif; other site 267747004529 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 267747004530 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 267747004531 oligomer interface [polypeptide binding]; other site 267747004532 active site residues [active] 267747004533 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 267747004534 oligomer interface [polypeptide binding]; other site 267747004535 active site residues [active] 267747004536 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 267747004537 Domain of unknown function DUF20; Region: UPF0118; cl00465 267747004538 trigger factor; Provisional; Region: tig; PRK01490 267747004539 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 267747004540 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 267747004541 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 267747004542 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 267747004543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747004544 ATP binding site [chemical binding]; other site 267747004545 putative Mg++ binding site [ion binding]; other site 267747004546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747004547 nucleotide binding region [chemical binding]; other site 267747004548 ATP-binding site [chemical binding]; other site 267747004549 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 267747004550 conserved cys residue [active] 267747004551 ParB-like nuclease domain; Region: ParBc; cl02129 267747004552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747004553 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 267747004554 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 267747004555 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 267747004556 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 267747004557 Phage terminase, small subunit; Region: Terminase_4; cl01525 267747004558 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 267747004559 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 267747004560 active site 267747004561 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 267747004562 active site 267747004563 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004564 ATP binding site [chemical binding]; other site 267747004565 putative Mg++ binding site [ion binding]; other site 267747004566 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 267747004567 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 267747004568 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 267747004569 D5 N terminal like; Region: D5_N; cl07360 267747004570 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 267747004571 BRO family, N-terminal domain; Region: Bro-N; cl10591 267747004572 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 267747004573 Abi-like protein; Region: Abi_2; cl01988 267747004574 Cytochrome C biogenesis protein; Region: CcmH; cl01179 267747004575 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 267747004576 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 267747004577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 267747004578 DNA binding residues [nucleotide binding] 267747004579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004580 Walker A/P-loop; other site 267747004581 ATP binding site [chemical binding]; other site 267747004582 chromosome segregation protein; Provisional; Region: PRK02224 267747004583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267747004584 non-specific DNA binding site [nucleotide binding]; other site 267747004585 salt bridge; other site 267747004586 sequence-specific DNA binding site [nucleotide binding]; other site 267747004587 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 267747004588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747004589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747004590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004591 Restriction endonuclease [Defense mechanisms]; Region: COG3587 267747004592 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 267747004593 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 267747004594 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 267747004595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747004596 ATP binding site [chemical binding]; other site 267747004597 putative Mg++ binding site [ion binding]; other site 267747004598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747004599 ATP-binding site [chemical binding]; other site 267747004600 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 267747004601 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004603 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 267747004604 HIRAN domain; Region: HIRAN; cl07418 267747004605 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267747004606 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 267747004607 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 267747004608 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 267747004609 dimer interface [polypeptide binding]; other site 267747004610 putative anticodon binding site; other site 267747004611 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 267747004612 motif 1; other site 267747004613 dimer interface [polypeptide binding]; other site 267747004614 active site 267747004615 motif 2; other site 267747004616 motif 3; other site 267747004617 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 267747004618 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 267747004619 putative DNA binding site [nucleotide binding]; other site 267747004620 catalytic residue [active] 267747004621 putative H2TH interface [polypeptide binding]; other site 267747004622 putative catalytic residues [active] 267747004623 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 267747004624 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 267747004625 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 267747004626 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747004627 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 267747004628 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 267747004629 nucleotide binding pocket [chemical binding]; other site 267747004630 K-X-D-G motif; other site 267747004631 catalytic site [active] 267747004632 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 267747004633 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 267747004634 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 267747004635 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 267747004636 Dimer interface [polypeptide binding]; other site 267747004637 BRCT sequence motif; other site 267747004638 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 267747004639 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 267747004640 Zn binding site [ion binding]; other site 267747004641 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 267747004642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004643 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 267747004644 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 267747004645 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 267747004646 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 267747004647 active site 267747004648 catalytic site [active] 267747004649 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267747004650 active site 267747004651 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 267747004652 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267747004653 active site 267747004654 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 267747004655 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747004656 Helix-turn-helix domains; Region: HTH; cl00088 267747004657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 267747004658 FAD binding domain; Region: FAD_binding_4; pfam01565 267747004659 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 267747004660 Helix-turn-helix domains; Region: HTH; cl00088 267747004661 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 267747004662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004663 Walker A/P-loop; other site 267747004664 ATP binding site [chemical binding]; other site 267747004665 Q-loop/lid; other site 267747004666 ABC transporter signature motif; other site 267747004667 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 267747004668 ABC transporter; Region: ABC_tran_2; pfam12848 267747004669 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 267747004670 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 267747004671 dimer interface [polypeptide binding]; other site 267747004672 ssDNA binding site [nucleotide binding]; other site 267747004673 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267747004674 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 267747004675 G1 box; other site 267747004676 GTP/Mg2+ binding site [chemical binding]; other site 267747004677 Switch I region; other site 267747004678 G2 box; other site 267747004679 Switch II region; other site 267747004680 G3 box; other site 267747004681 G4 box; other site 267747004682 G5 box; other site 267747004683 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004684 GTP/Mg2+ binding site [chemical binding]; other site 267747004685 G4 box; other site 267747004686 G5 box; other site 267747004687 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 267747004688 G1 box; other site 267747004689 G1 box; other site 267747004690 GTP/Mg2+ binding site [chemical binding]; other site 267747004691 Switch I region; other site 267747004692 Switch I region; other site 267747004693 G2 box; other site 267747004694 G2 box; other site 267747004695 Switch II region; other site 267747004696 G3 box; other site 267747004697 G4 box; other site 267747004698 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 267747004699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747004700 putative substrate translocation pore; other site 267747004701 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 267747004702 putative active site [active] 267747004703 putative substrate binding site [chemical binding]; other site 267747004704 catalytic site [active] 267747004705 dimer interface [polypeptide binding]; other site 267747004706 Amino acid permease; Region: AA_permease; cl00524 267747004707 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747004708 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 267747004709 Catalytic domain of Protein Kinases; Region: PKc; cd00180 267747004710 active site 267747004711 ATP binding site [chemical binding]; other site 267747004712 substrate binding site [chemical binding]; other site 267747004713 activation loop (A-loop); other site 267747004714 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 267747004715 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 267747004716 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 267747004717 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 267747004718 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 267747004719 generic binding surface I; other site 267747004720 generic binding surface II; other site 267747004721 DNA Polymerase Y-family; Region: PolY_like; cd03468 267747004722 active site 267747004723 DNA binding site [nucleotide binding] 267747004724 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 267747004725 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 267747004726 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 267747004727 catalytic triad [active] 267747004728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004729 dimer interface [polypeptide binding]; other site 267747004730 conserved gate region; other site 267747004731 putative PBP binding loops; other site 267747004732 ABC-ATPase subunit interface; other site 267747004733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747004734 dimer interface [polypeptide binding]; other site 267747004735 conserved gate region; other site 267747004736 putative PBP binding loops; other site 267747004737 ABC-ATPase subunit interface; other site 267747004738 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 267747004739 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 267747004740 catalytic triad [active] 267747004741 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 267747004742 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 267747004743 active site 267747004744 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 267747004745 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 267747004746 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 267747004747 active site 267747004748 oxyanion hole [active] 267747004749 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 267747004750 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 267747004751 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 267747004752 putative active site [active] 267747004753 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 267747004754 DNA polymerase IV; Provisional; Region: PRK03348 267747004755 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 267747004756 active site 267747004757 DNA binding site [nucleotide binding] 267747004758 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 267747004759 folate binding site [chemical binding]; other site 267747004760 NADP+ binding site [chemical binding]; other site 267747004761 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 267747004762 dimerization interface [polypeptide binding]; other site 267747004763 active site 267747004764 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 267747004765 active site 267747004766 dimerization interface [polypeptide binding]; other site 267747004767 ribonuclease PH; Reviewed; Region: rph; PRK00173 267747004768 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 267747004769 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 267747004770 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 267747004771 FeoA domain; Region: FeoA; cl00838 267747004772 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 267747004773 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 267747004774 G1 box; other site 267747004775 GTP/Mg2+ binding site [chemical binding]; other site 267747004776 Switch I region; other site 267747004777 G2 box; other site 267747004778 G3 box; other site 267747004779 Switch II region; other site 267747004780 G4 box; other site 267747004781 G5 box; other site 267747004782 Nucleoside recognition; Region: Gate; cl00486 267747004783 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 267747004784 Nucleoside recognition; Region: Gate; cl00486 267747004785 NifU-like domain; Region: NifU; cl00484 267747004786 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 267747004787 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 267747004788 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 267747004789 active site 267747004790 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 267747004791 IHF dimer interface [polypeptide binding]; other site 267747004792 IHF - DNA interface [nucleotide binding]; other site 267747004793 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 267747004794 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 267747004795 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 267747004796 RDD family; Region: RDD; cl00746 267747004797 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 267747004798 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 267747004799 trimer interface [polypeptide binding]; other site 267747004800 active site 267747004801 dimer interface [polypeptide binding]; other site 267747004802 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 267747004803 Cation efflux family; Region: Cation_efflux; cl00316 267747004804 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 267747004805 Trm112p-like protein; Region: Trm112p; cl01066 267747004806 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 267747004807 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 267747004808 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 267747004809 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 267747004810 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267747004811 active site 267747004812 Transcription factor WhiB; Region: Whib; pfam02467 267747004813 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 267747004814 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 267747004815 Substrate binding site; other site 267747004816 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747004817 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 267747004818 Ligand binding site; other site 267747004819 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 267747004820 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 267747004821 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 267747004822 domain; Region: Glyco_hydro_2; pfam00703 267747004823 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 267747004824 AIR carboxylase; Region: AIRC; cl00310 267747004825 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 267747004826 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747004827 Bacterial membrane flanked domain; Region: DUF304; cl01348 267747004828 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 267747004829 active site pocket [active] 267747004830 oxyanion hole [active] 267747004831 catalytic triad [active] 267747004832 active site nucleophile [active] 267747004833 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 267747004834 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 267747004835 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 267747004836 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 267747004837 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 267747004838 Maf-like protein; Region: Maf; pfam02545 267747004839 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 267747004840 active site 267747004841 dimer interface [polypeptide binding]; other site 267747004842 short chain dehydrogenase; Provisional; Region: PRK12937 267747004843 classical (c) SDRs; Region: SDR_c; cd05233 267747004844 NAD(P) binding site [chemical binding]; other site 267747004845 active site 267747004846 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 267747004847 dimer interface [polypeptide binding]; other site 267747004848 substrate binding site [chemical binding]; other site 267747004849 ATP binding site [chemical binding]; other site 267747004850 TQXA domain; Region: TQXA_dom; TIGR03934 267747004851 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 267747004852 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 267747004853 nudix motif; other site 267747004854 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 267747004855 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267747004856 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747004857 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 267747004858 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 267747004859 carboxyltransferase (CT) interaction site; other site 267747004860 biotinylation site [posttranslational modification]; other site 267747004861 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 267747004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267747004864 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 267747004865 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 267747004866 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 267747004867 active site 267747004868 substrate binding site [chemical binding]; other site 267747004869 metal binding site [ion binding]; metal-binding site 267747004870 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 267747004871 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747004872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004873 active site 267747004874 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 267747004875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747004876 putative substrate translocation pore; other site 267747004877 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 267747004878 active site 267747004879 substrate binding site [chemical binding]; other site 267747004880 catalytic site [active] 267747004881 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 267747004882 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 267747004883 active site 267747004884 HIGH motif; other site 267747004885 KMSKS motif; other site 267747004886 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 267747004887 tRNA binding surface [nucleotide binding]; other site 267747004888 anticodon binding site; other site 267747004889 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 267747004890 RNA/DNA hybrid binding site [nucleotide binding]; other site 267747004891 active site 267747004892 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 267747004893 active site 267747004894 catalytic motif [active] 267747004895 Zn binding site [ion binding]; other site 267747004896 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 267747004897 TM-ABC transporter signature motif; other site 267747004898 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 267747004899 TM-ABC transporter signature motif; other site 267747004900 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 267747004901 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 267747004902 Walker A/P-loop; other site 267747004903 ATP binding site [chemical binding]; other site 267747004904 Q-loop/lid; other site 267747004905 ABC transporter signature motif; other site 267747004906 Walker B; other site 267747004907 D-loop; other site 267747004908 H-loop/switch region; other site 267747004909 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 267747004910 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 267747004911 ligand binding site [chemical binding]; other site 267747004912 Phosphotransferase enzyme family; Region: APH; pfam01636 267747004913 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 267747004914 Domain of unknown function DUF21; Region: DUF21; pfam01595 267747004915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 267747004916 Transporter associated domain; Region: CorC_HlyC; cl08393 267747004917 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 267747004918 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 267747004919 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 267747004920 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 267747004921 active site 267747004922 substrate binding site [chemical binding]; other site 267747004923 cosubstrate binding site; other site 267747004924 catalytic site [active] 267747004925 malate dehydrogenase; Provisional; Region: PRK05442 267747004926 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 267747004927 NAD(P) binding site [chemical binding]; other site 267747004928 dimer interface [polypeptide binding]; other site 267747004929 malate binding site [chemical binding]; other site 267747004930 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 267747004931 putative catalytic cysteine [active] 267747004932 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 267747004933 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 267747004934 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 267747004935 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 267747004936 homodimer interface [polypeptide binding]; other site 267747004937 NADP binding site [chemical binding]; other site 267747004938 substrate binding site [chemical binding]; other site 267747004939 Phosphoesterase family; Region: Phosphoesterase; cl15450 267747004940 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 267747004941 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 267747004942 purine monophosphate binding site [chemical binding]; other site 267747004943 dimer interface [polypeptide binding]; other site 267747004944 putative catalytic residues [active] 267747004945 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 267747004946 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 267747004947 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 267747004948 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 267747004949 active site 267747004950 cosubstrate binding site; other site 267747004951 substrate binding site [chemical binding]; other site 267747004952 catalytic site [active] 267747004953 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 267747004954 homopentamer interface [polypeptide binding]; other site 267747004955 active site 267747004956 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 267747004957 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 267747004958 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 267747004959 dimerization interface [polypeptide binding]; other site 267747004960 active site 267747004961 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 267747004962 Lumazine binding domain; Region: Lum_binding; pfam00677 267747004963 Lumazine binding domain; Region: Lum_binding; pfam00677 267747004964 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 267747004965 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 267747004966 catalytic motif [active] 267747004967 Zn binding site [ion binding]; other site 267747004968 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 267747004969 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 267747004970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747004971 CoA-ligase; Region: Ligase_CoA; pfam00549 267747004972 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 267747004973 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747004974 CoA-ligase; Region: Ligase_CoA; pfam00549 267747004975 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 267747004976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747004977 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 267747004978 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 267747004979 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 267747004980 Walker A/P-loop; other site 267747004981 ATP binding site [chemical binding]; other site 267747004982 Q-loop/lid; other site 267747004983 ABC transporter signature motif; other site 267747004984 Walker B; other site 267747004985 D-loop; other site 267747004986 H-loop/switch region; other site 267747004987 NIL domain; Region: NIL; cl09633 267747004988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747004989 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 267747004990 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 267747004991 putative active site [active] 267747004992 catalytic site [active] 267747004993 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 267747004994 putative active site [active] 267747004995 catalytic site [active] 267747004996 PspC domain; Region: PspC; cl00864 267747004997 GMP synthase; Reviewed; Region: guaA; PRK00074 267747004998 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 267747004999 AMP/PPi binding site [chemical binding]; other site 267747005000 candidate oxyanion hole; other site 267747005001 catalytic triad [active] 267747005002 potential glutamine specificity residues [chemical binding]; other site 267747005003 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 267747005004 ATP Binding subdomain [chemical binding]; other site 267747005005 Ligand Binding sites [chemical binding]; other site 267747005006 Dimerization subdomain; other site 267747005007 serine O-acetyltransferase; Region: cysE; TIGR01172 267747005008 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 267747005009 trimer interface [polypeptide binding]; other site 267747005010 active site 267747005011 substrate binding site [chemical binding]; other site 267747005012 CoA binding site [chemical binding]; other site 267747005013 Chorismate mutase type II; Region: CM_2; cl00693 267747005014 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 267747005015 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 267747005016 active site 267747005017 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 267747005018 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 267747005019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 267747005020 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 267747005021 active site 267747005022 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 267747005023 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 267747005024 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 267747005025 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 267747005026 ring oligomerisation interface [polypeptide binding]; other site 267747005027 ATP/Mg binding site [chemical binding]; other site 267747005028 stacking interactions; other site 267747005029 hinge regions; other site 267747005030 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 267747005031 oligomerisation interface [polypeptide binding]; other site 267747005032 mobile loop; other site 267747005033 roof hairpin; other site 267747005034 Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263 267747005035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747005036 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267747005037 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 267747005038 Walker A/P-loop; other site 267747005039 ATP binding site [chemical binding]; other site 267747005040 Q-loop/lid; other site 267747005041 ABC transporter signature motif; other site 267747005042 Walker B; other site 267747005043 D-loop; other site 267747005044 H-loop/switch region; other site 267747005045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 267747005046 ABC-ATPase subunit interface; other site 267747005047 dimer interface [polypeptide binding]; other site 267747005048 putative PBP binding regions; other site 267747005049 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 267747005050 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 267747005051 putative ligand binding residues [chemical binding]; other site 267747005052 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 267747005053 putative active site [active] 267747005054 nucleotide binding site [chemical binding]; other site 267747005055 nudix motif; other site 267747005056 putative metal binding site [ion binding]; other site 267747005057 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 267747005058 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 267747005059 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 267747005060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267747005061 Coenzyme A binding pocket [chemical binding]; other site 267747005062 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 267747005063 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 267747005064 Domain of unknown function (DUF1994); Region: DUF1994; cl09179 267747005065 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 267747005066 DEAD-like helicases superfamily; Region: DEXDc; smart00487 267747005067 ATP binding site [chemical binding]; other site 267747005068 Mg++ binding site [ion binding]; other site 267747005069 motif III; other site 267747005070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747005071 nucleotide binding region [chemical binding]; other site 267747005072 ATP-binding site [chemical binding]; other site 267747005073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747005074 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747005075 Walker A/P-loop; other site 267747005076 ATP binding site [chemical binding]; other site 267747005077 Q-loop/lid; other site 267747005078 ABC transporter signature motif; other site 267747005079 Walker B; other site 267747005080 D-loop; other site 267747005081 H-loop/switch region; other site 267747005082 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 267747005083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267747005084 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 267747005085 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 267747005086 putative substrate binding site [chemical binding]; other site 267747005087 putative ATP binding site [chemical binding]; other site 267747005088 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 267747005089 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 267747005090 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 267747005091 glutaminase active site [active] 267747005092 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 267747005093 dimer interface [polypeptide binding]; other site 267747005094 active site 267747005095 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 267747005096 dimer interface [polypeptide binding]; other site 267747005097 active site 267747005098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747005099 pantothenate kinase; Provisional; Region: PRK05439 267747005100 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 267747005101 ATP-binding site [chemical binding]; other site 267747005102 CoA-binding site [chemical binding]; other site 267747005103 Mg2+-binding site [ion binding]; other site 267747005104 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 267747005105 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 267747005106 active site 267747005107 substrate binding site [chemical binding]; other site 267747005108 metal binding site [ion binding]; metal-binding site 267747005109 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 267747005110 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 267747005111 23S rRNA interface [nucleotide binding]; other site 267747005112 L3 interface [polypeptide binding]; other site 267747005113 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 267747005114 active site 267747005115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747005116 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 267747005117 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 267747005118 dimerization interface 3.5A [polypeptide binding]; other site 267747005119 active site 267747005120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747005121 S-adenosylmethionine binding site [chemical binding]; other site 267747005122 Cobalt transport protein; Region: CbiQ; cl00463 267747005123 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747005124 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 267747005125 Walker A/P-loop; other site 267747005126 ATP binding site [chemical binding]; other site 267747005127 Q-loop/lid; other site 267747005128 ABC transporter signature motif; other site 267747005129 Walker B; other site 267747005130 D-loop; other site 267747005131 H-loop/switch region; other site 267747005132 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747005133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747005134 Walker A/P-loop; other site 267747005135 ATP binding site [chemical binding]; other site 267747005136 Q-loop/lid; other site 267747005137 ABC transporter signature motif; other site 267747005138 Walker B; other site 267747005139 D-loop; other site 267747005140 H-loop/switch region; other site 267747005141 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 267747005142 classical (c) SDRs; Region: SDR_c; cd05233 267747005143 NAD(P) binding site [chemical binding]; other site 267747005144 active site 267747005145 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 267747005146 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 267747005147 Walker A/P-loop; other site 267747005148 ATP binding site [chemical binding]; other site 267747005149 Q-loop/lid; other site 267747005150 ABC transporter signature motif; other site 267747005151 Walker B; other site 267747005152 D-loop; other site 267747005153 H-loop/switch region; other site 267747005154 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 267747005155 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 267747005156 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 267747005157 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 267747005158 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 267747005159 Beta-galactosidase, domain 2; Region: BetaGal_dom2; cl11086 267747005160 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 267747005161 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 267747005162 active site 267747005163 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 267747005164 sugar binding site [chemical binding]; other site 267747005165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267747005167 putative substrate translocation pore; other site 267747005168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267747005169 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 267747005170 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 267747005171 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 267747005172 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 267747005173 alphaNTD homodimer interface [polypeptide binding]; other site 267747005174 alphaNTD - beta interaction site [polypeptide binding]; other site 267747005175 alphaNTD - beta' interaction site [polypeptide binding]; other site 267747005176 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 267747005177 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 267747005178 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 267747005179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267747005180 RNA binding surface [nucleotide binding]; other site 267747005181 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 267747005182 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 267747005183 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 267747005184 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 267747005185 rRNA binding site [nucleotide binding]; other site 267747005186 predicted 30S ribosome binding site; other site 267747005187 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 267747005188 active site 267747005189 adenylate kinase; Reviewed; Region: adk; PRK00279 267747005190 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 267747005191 AMP-binding site [chemical binding]; other site 267747005192 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 267747005193 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 267747005194 SecY translocase; Region: SecY; pfam00344 267747005195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267747005196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005197 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 267747005198 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 267747005199 putative active site [active] 267747005200 catalytic site [active] 267747005201 putative metal binding site [ion binding]; other site 267747005202 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 267747005203 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 267747005204 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 267747005205 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 267747005206 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 267747005207 23S rRNA binding site [nucleotide binding]; other site 267747005208 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 267747005209 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 267747005210 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 267747005211 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 267747005212 23S rRNA interface [nucleotide binding]; other site 267747005213 5S rRNA interface [nucleotide binding]; other site 267747005214 L27 interface [polypeptide binding]; other site 267747005215 L5 interface [polypeptide binding]; other site 267747005216 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 267747005217 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 267747005218 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 267747005219 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 267747005220 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 267747005221 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 267747005222 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 267747005223 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 267747005224 KOW motif; Region: KOW; cl00354 267747005225 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 267747005226 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 267747005227 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 267747005228 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 267747005229 23S rRNA interface [nucleotide binding]; other site 267747005230 putative translocon interaction site; other site 267747005231 signal recognition particle (SRP54) interaction site; other site 267747005232 L23 interface [polypeptide binding]; other site 267747005233 trigger factor interaction site; other site 267747005234 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 267747005235 23S rRNA interface [nucleotide binding]; other site 267747005236 5S rRNA interface [nucleotide binding]; other site 267747005237 putative antibiotic binding site [chemical binding]; other site 267747005238 L25 interface [polypeptide binding]; other site 267747005239 L27 interface [polypeptide binding]; other site 267747005240 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 267747005241 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 267747005242 G-X-X-G motif; other site 267747005243 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 267747005244 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 267747005245 putative translocon binding site; other site 267747005246 protein-rRNA interface [nucleotide binding]; other site 267747005247 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 267747005248 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 267747005249 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 267747005250 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 267747005251 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 267747005252 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 267747005253 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 267747005254 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 267747005255 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 267747005256 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 267747005257 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 267747005258 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267747005259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267747005260 catalytic residue [active] 267747005261 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 267747005262 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 267747005263 HIGH motif; other site 267747005264 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 267747005265 active site 267747005266 KMSKS motif; other site 267747005267 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 267747005268 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747005269 active site 267747005270 HIGH motif; other site 267747005271 nucleotide binding site [chemical binding]; other site 267747005272 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267747005273 active site 267747005274 KMSKS motif; other site 267747005275 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 267747005276 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 267747005277 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 267747005278 active site 267747005279 metal binding site [ion binding]; metal-binding site 267747005280 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 267747005281 Predicted membrane protein (DUF2319); Region: DUF2319; cl15412 267747005282 elongation factor Tu; Reviewed; Region: PRK00049 267747005283 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 267747005284 G1 box; other site 267747005285 GEF interaction site [polypeptide binding]; other site 267747005286 GTP/Mg2+ binding site [chemical binding]; other site 267747005287 Switch I region; other site 267747005288 G2 box; other site 267747005289 G3 box; other site 267747005290 Switch II region; other site 267747005291 G4 box; other site 267747005292 G5 box; other site 267747005293 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 267747005294 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 267747005295 Antibiotic Binding Site [chemical binding]; other site 267747005296 DAZ associated protein 2 (DAZAP2); Region: DAZAP2; pfam11029 267747005297 elongation factor G; Reviewed; Region: PRK00007 267747005298 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 267747005299 G1 box; other site 267747005300 putative GEF interaction site [polypeptide binding]; other site 267747005301 GTP/Mg2+ binding site [chemical binding]; other site 267747005302 Switch I region; other site 267747005303 G2 box; other site 267747005304 G3 box; other site 267747005305 Switch II region; other site 267747005306 G4 box; other site 267747005307 G5 box; other site 267747005308 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 267747005309 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 267747005310 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 267747005311 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 267747005312 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 267747005313 S17 interaction site [polypeptide binding]; other site 267747005314 S8 interaction site; other site 267747005315 16S rRNA interaction site [nucleotide binding]; other site 267747005316 streptomycin interaction site [chemical binding]; other site 267747005317 23S rRNA interaction site [nucleotide binding]; other site 267747005318 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 267747005319 Filamin/ABP280 repeat; Region: Filamin; cl02665 267747005320 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 267747005321 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747005322 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 267747005323 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 267747005324 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 267747005325 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 267747005326 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 267747005327 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 267747005328 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 267747005329 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 267747005330 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 267747005331 G-loop; other site 267747005332 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 267747005333 DNA binding site [nucleotide binding] 267747005334 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 267747005335 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 267747005336 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 267747005337 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 267747005338 RPB1 interaction site [polypeptide binding]; other site 267747005339 RPB10 interaction site [polypeptide binding]; other site 267747005340 RPB11 interaction site [polypeptide binding]; other site 267747005341 RPB3 interaction site [polypeptide binding]; other site 267747005342 RPB12 interaction site [polypeptide binding]; other site 267747005343 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 267747005344 core dimer interface [polypeptide binding]; other site 267747005345 peripheral dimer interface [polypeptide binding]; other site 267747005346 L10 interface [polypeptide binding]; other site 267747005347 L11 interface [polypeptide binding]; other site 267747005348 putative EF-Tu interaction site [polypeptide binding]; other site 267747005349 putative EF-G interaction site [polypeptide binding]; other site 267747005350 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 267747005351 23S rRNA interface [nucleotide binding]; other site 267747005352 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 267747005353 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 267747005354 mRNA/rRNA interface [nucleotide binding]; other site 267747005355 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 267747005356 23S rRNA interface [nucleotide binding]; other site 267747005357 putative thiostrepton binding site; other site 267747005358 L7/L12 interface [polypeptide binding]; other site 267747005359 L25 interface [polypeptide binding]; other site 267747005360 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 267747005361 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 267747005362 putative homodimer interface [polypeptide binding]; other site 267747005363 KOW motif; Region: KOW; cl00354 267747005364 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 267747005365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747005366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747005367 homodimer interface [polypeptide binding]; other site 267747005368 catalytic residue [active] 267747005369 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 267747005370 FAD binding domain; Region: FAD_binding_4; pfam01565 267747005371 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 267747005372 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 267747005373 active site 267747005374 catalytic site [active] 267747005375 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 267747005376 active site 267747005377 catalytic site [active] 267747005378 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 267747005379 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 267747005380 putative active site [active] 267747005381 putative DNA binding site [nucleotide binding]; other site 267747005382 putative phosphate binding site [ion binding]; other site 267747005383 putative catalytic site [active] 267747005384 metal binding site A [ion binding]; metal-binding site 267747005385 putative AP binding site [nucleotide binding]; other site 267747005386 putative metal binding site B [ion binding]; other site 267747005387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267747005388 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 267747005389 substrate binding site [chemical binding]; other site 267747005390 oxyanion hole (OAH) forming residues; other site 267747005391 trimer interface [polypeptide binding]; other site 267747005392 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 267747005393 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 267747005394 4Fe-4S binding domain; Region: Fer4; cl02805 267747005395 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 267747005396 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 267747005397 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 267747005398 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 267747005399 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 267747005400 dimer interface [polypeptide binding]; other site 267747005401 PYR/PP interface [polypeptide binding]; other site 267747005402 TPP binding site [chemical binding]; other site 267747005403 substrate binding site [chemical binding]; other site 267747005404 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 267747005405 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 267747005406 TPP-binding site [chemical binding]; other site 267747005407 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 267747005408 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 267747005409 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 267747005410 active site 267747005411 catalytic triad [active] 267747005412 oxyanion hole [active] 267747005413 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 267747005414 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 267747005415 active site 267747005416 Zn binding site [ion binding]; other site 267747005417 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 267747005418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747005419 Walker A/P-loop; other site 267747005420 ATP binding site [chemical binding]; other site 267747005421 Q-loop/lid; other site 267747005422 ABC transporter signature motif; other site 267747005423 Walker B; other site 267747005424 D-loop; other site 267747005425 H-loop/switch region; other site 267747005426 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 267747005427 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 267747005428 Walker A/P-loop; other site 267747005429 ATP binding site [chemical binding]; other site 267747005430 Q-loop/lid; other site 267747005431 ABC transporter signature motif; other site 267747005432 Walker B; other site 267747005433 D-loop; other site 267747005434 H-loop/switch region; other site 267747005435 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 267747005436 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 267747005437 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 267747005438 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 267747005439 substrate binding pocket [chemical binding]; other site 267747005440 chain length determination region; other site 267747005441 substrate-Mg2+ binding site; other site 267747005442 catalytic residues [active] 267747005443 aspartate-rich region 1; other site 267747005444 active site lid residues [active] 267747005445 aspartate-rich region 2; other site 267747005446 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 267747005447 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 267747005448 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 267747005449 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 267747005450 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 267747005451 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 267747005452 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 267747005453 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 267747005454 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 267747005455 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 267747005456 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 267747005457 4Fe-4S binding domain; Region: Fer4; cl02805 267747005458 4Fe-4S binding domain; Region: Fer4; cl02805 267747005459 NADH dehydrogenase; Region: NADHdh; cl00469 267747005460 NADH dehydrogenase subunit G; Validated; Region: PRK07860 267747005461 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 267747005462 catalytic loop [active] 267747005463 iron binding site [ion binding]; other site 267747005464 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 267747005465 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 267747005466 [4Fe-4S] binding site [ion binding]; other site 267747005467 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 267747005468 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 267747005469 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 267747005470 SLBB domain; Region: SLBB; pfam10531 267747005471 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 267747005472 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 267747005473 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 267747005474 putative dimer interface [polypeptide binding]; other site 267747005475 [2Fe-2S] cluster binding site [ion binding]; other site 267747005476 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 267747005477 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 267747005478 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 267747005479 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 267747005480 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 267747005481 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 267747005482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747005483 chorismate binding enzyme; Region: Chorismate_bind; cl10555 267747005484 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 267747005485 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 267747005486 Walker A/P-loop; other site 267747005487 ATP binding site [chemical binding]; other site 267747005488 Q-loop/lid; other site 267747005489 ABC transporter signature motif; other site 267747005490 Walker B; other site 267747005491 D-loop; other site 267747005492 H-loop/switch region; other site 267747005493 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 267747005494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747005495 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 267747005496 UbiA prenyltransferase family; Region: UbiA; cl00337 267747005497 H+ Antiporter protein; Region: 2A0121; TIGR00900 267747005498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 267747005500 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 267747005501 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 267747005502 DAK2 domain; Region: Dak2; cl03685 267747005503 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 267747005504 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 267747005505 catalytic motif [active] 267747005506 Zn binding site [ion binding]; other site 267747005507 Cation efflux family; Region: Cation_efflux; cl00316 267747005508 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 267747005509 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 267747005510 NAD binding site [chemical binding]; other site 267747005511 dimer interface [polypeptide binding]; other site 267747005512 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267747005513 substrate binding site [chemical binding]; other site 267747005514 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 267747005515 active site 267747005516 nucleophile elbow; other site 267747005517 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 267747005518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747005519 UMP phosphatase; Provisional; Region: PRK10444 267747005520 active site 267747005521 motif I; other site 267747005522 motif II; other site 267747005523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747005524 Right handed beta helix region; Region: Beta_helix; pfam13229 267747005525 Helix-turn-helix domains; Region: HTH; cl00088 267747005526 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 267747005527 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747005528 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 267747005529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005530 dimer interface [polypeptide binding]; other site 267747005531 conserved gate region; other site 267747005532 putative PBP binding loops; other site 267747005533 ABC-ATPase subunit interface; other site 267747005534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 267747005535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005536 dimer interface [polypeptide binding]; other site 267747005537 conserved gate region; other site 267747005538 putative PBP binding loops; other site 267747005539 ABC-ATPase subunit interface; other site 267747005540 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747005541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747005542 Bacterial SH3 domain; Region: SH3_3; cl02551 267747005543 Bacterial SH3 domain; Region: SH3_3; cl02551 267747005544 Bacterial SH3 domain; Region: SH3_3; cl02551 267747005545 NlpC/P60 family; Region: NLPC_P60; cl11438 267747005546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 267747005547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005548 dimer interface [polypeptide binding]; other site 267747005549 conserved gate region; other site 267747005550 putative PBP binding loops; other site 267747005551 ABC-ATPase subunit interface; other site 267747005552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005553 dimer interface [polypeptide binding]; other site 267747005554 conserved gate region; other site 267747005555 putative PBP binding loops; other site 267747005556 ABC-ATPase subunit interface; other site 267747005557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747005558 Protein of unknown function (DUF1749); Region: DUF1749; pfam08538 267747005559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267747005560 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 267747005561 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 267747005562 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 267747005563 dimerization interface [polypeptide binding]; other site 267747005564 putative ATP binding site [chemical binding]; other site 267747005565 amidophosphoribosyltransferase; Provisional; Region: PRK07847 267747005566 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 267747005567 active site 267747005568 tetramer interface [polypeptide binding]; other site 267747005569 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747005570 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 267747005571 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 267747005572 active site 267747005573 metal binding site [ion binding]; metal-binding site 267747005574 dimer interface [polypeptide binding]; other site 267747005575 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 267747005576 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 267747005577 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 267747005578 Glutamine amidotransferase class-I; Region: GATase; pfam00117 267747005579 glutamine binding [chemical binding]; other site 267747005580 catalytic triad [active] 267747005581 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 267747005582 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 267747005583 chorismate binding enzyme; Region: Chorismate_bind; cl10555 267747005584 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 267747005585 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 267747005586 dimerization interface [polypeptide binding]; other site 267747005587 ATP binding site [chemical binding]; other site 267747005588 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 267747005589 dimerization interface [polypeptide binding]; other site 267747005590 ATP binding site [chemical binding]; other site 267747005591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005592 putative substrate translocation pore; other site 267747005593 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267747005594 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 267747005595 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 267747005596 Zn binding site [ion binding]; other site 267747005597 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 267747005598 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 267747005599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747005600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747005601 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267747005602 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 267747005603 active site 267747005604 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 267747005605 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 267747005606 active site 267747005607 catalytic triad [active] 267747005608 oxyanion hole [active] 267747005609 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 267747005610 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747005611 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 267747005612 putative active site [active] 267747005613 catalytic triad [active] 267747005614 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 267747005615 ATP binding site [chemical binding]; other site 267747005616 active site 267747005617 substrate binding site [chemical binding]; other site 267747005618 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 267747005619 peroxiredoxin; Region: AhpC; TIGR03137 267747005620 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 267747005621 dimer interface [polypeptide binding]; other site 267747005622 decamer (pentamer of dimers) interface [polypeptide binding]; other site 267747005623 catalytic triad [active] 267747005624 peroxidatic and resolving cysteines [active] 267747005625 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 267747005626 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 267747005627 catalytic residue [active] 267747005628 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 267747005629 catalytic residues [active] 267747005630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747005631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 267747005632 Helix-turn-helix domains; Region: HTH; cl00088 267747005633 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 267747005634 dimerization interface [polypeptide binding]; other site 267747005635 adenylosuccinate lyase; Region: purB; TIGR00928 267747005636 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 267747005637 tetramer interface [polypeptide binding]; other site 267747005638 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 267747005639 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 267747005640 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747005641 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 267747005642 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 267747005643 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 267747005644 GDP-binding site [chemical binding]; other site 267747005645 ACT binding site; other site 267747005646 IMP binding site; other site 267747005647 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 267747005648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 267747005649 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 267747005650 DNA-binding site [nucleotide binding]; DNA binding site 267747005651 FCD domain; Region: FCD; cl11656 267747005652 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 267747005653 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 267747005654 putative active site cavity [active] 267747005655 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 267747005656 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 267747005657 inhibitor site; inhibition site 267747005658 active site 267747005659 dimer interface [polypeptide binding]; other site 267747005660 catalytic residue [active] 267747005661 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 267747005662 putative sialic acid transporter; Provisional; Region: PRK03893 267747005663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005664 putative substrate translocation pore; other site 267747005665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005666 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 267747005667 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 267747005668 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 267747005669 G1 box; other site 267747005670 putative GEF interaction site [polypeptide binding]; other site 267747005671 GTP/Mg2+ binding site [chemical binding]; other site 267747005672 Switch I region; other site 267747005673 G2 box; other site 267747005674 G3 box; other site 267747005675 Switch II region; other site 267747005676 G4 box; other site 267747005677 G5 box; other site 267747005678 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 267747005679 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 267747005680 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 267747005681 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 267747005682 carboxyltransferase (CT) interaction site; other site 267747005683 biotinylation site [posttranslational modification]; other site 267747005684 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 267747005685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 267747005686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 267747005687 oxaloacetate decarboxylase; Provisional; Region: PRK12330 267747005688 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 267747005689 active site 267747005690 catalytic residues [active] 267747005691 metal binding site [ion binding]; metal-binding site 267747005692 homodimer binding site [polypeptide binding]; other site 267747005693 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 267747005694 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 267747005695 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 267747005696 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 267747005697 active site 267747005698 intersubunit interface [polypeptide binding]; other site 267747005699 zinc binding site [ion binding]; other site 267747005700 Na+ binding site [ion binding]; other site 267747005701 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 267747005702 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 267747005703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747005704 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 267747005705 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 267747005706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 267747005707 SEC-C motif; Region: SEC-C; pfam02810 267747005708 benzoate transport; Region: 2A0115; TIGR00895 267747005709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005710 putative substrate translocation pore; other site 267747005711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747005712 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 267747005713 Clp amino terminal domain; Region: Clp_N; pfam02861 267747005714 Clp amino terminal domain; Region: Clp_N; pfam02861 267747005715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747005716 Walker A motif; other site 267747005717 ATP binding site [chemical binding]; other site 267747005718 Walker B motif; other site 267747005719 arginine finger; other site 267747005720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267747005721 Walker A motif; other site 267747005722 ATP binding site [chemical binding]; other site 267747005723 Walker B motif; other site 267747005724 arginine finger; other site 267747005725 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 267747005726 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 267747005727 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747005728 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 267747005729 catalytic residue [active] 267747005730 Flavin Reductases; Region: FlaRed; cl00801 267747005731 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 267747005732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267747005733 Histidine kinase; Region: HisKA_3; pfam07730 267747005734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747005735 ATP binding site [chemical binding]; other site 267747005736 Mg2+ binding site [ion binding]; other site 267747005737 G-X-G motif; other site 267747005738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267747005739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747005740 active site 267747005741 phosphorylation site [posttranslational modification] 267747005742 intermolecular recognition site; other site 267747005743 dimerization interface [polypeptide binding]; other site 267747005744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267747005745 DNA binding residues [nucleotide binding] 267747005746 dimerization interface [polypeptide binding]; other site 267747005747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267747005748 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 267747005749 Walker A/P-loop; other site 267747005750 ATP binding site [chemical binding]; other site 267747005751 Q-loop/lid; other site 267747005752 ABC transporter signature motif; other site 267747005753 Walker B; other site 267747005754 D-loop; other site 267747005755 H-loop/switch region; other site 267747005756 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 267747005757 FtsX-like permease family; Region: FtsX; pfam02687 267747005758 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 267747005759 FtsX-like permease family; Region: FtsX; pfam02687 267747005760 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 267747005761 nudix motif; other site 267747005762 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747005763 Amino acid permease; Region: AA_permease; cl00524 267747005764 Predicted permease [General function prediction only]; Region: COG2985 267747005765 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 267747005766 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 267747005767 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 267747005768 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 267747005769 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 267747005770 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 267747005771 putative NAD(P) binding site [chemical binding]; other site 267747005772 catalytic Zn binding site [ion binding]; other site 267747005773 structural Zn binding site [ion binding]; other site 267747005774 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 267747005775 active site 267747005776 catalytic triad [active] 267747005777 oxyanion hole [active] 267747005778 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 267747005779 DNA binding residues [nucleotide binding] 267747005780 putative dimer interface [polypeptide binding]; other site 267747005781 chaperone protein DnaJ; Provisional; Region: PRK14295 267747005782 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 267747005783 HSP70 interaction site [polypeptide binding]; other site 267747005784 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 267747005785 Zn binding sites [ion binding]; other site 267747005786 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 267747005787 dimer interface [polypeptide binding]; other site 267747005788 hypothetical protein; Provisional; Region: PRK11281 267747005789 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 267747005790 dimer interface [polypeptide binding]; other site 267747005791 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 267747005792 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 267747005793 Phosphate transporter family; Region: PHO4; cl00396 267747005794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267747005795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747005796 active site 267747005797 phosphorylation site [posttranslational modification] 267747005798 intermolecular recognition site; other site 267747005799 dimerization interface [polypeptide binding]; other site 267747005800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267747005801 DNA binding site [nucleotide binding] 267747005802 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 267747005803 intersubunit interface [polypeptide binding]; other site 267747005804 active site 267747005805 catalytic residue [active] 267747005806 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 267747005807 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 267747005808 pyruvate phosphate dikinase; Provisional; Region: PRK09279 267747005809 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 267747005810 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 267747005811 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 267747005812 Domain of unknown function (DUF299); Region: DUF299; cl00780 267747005813 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 267747005814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267747005815 S-adenosylmethionine binding site [chemical binding]; other site 267747005816 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 267747005817 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747005818 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 267747005819 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 267747005820 active site 267747005821 phosphate binding residues; other site 267747005822 catalytic residues [active] 267747005823 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747005824 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 267747005825 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 267747005826 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 267747005827 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747005828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747005829 DNA binding site [nucleotide binding] 267747005830 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 267747005831 ligand binding site [chemical binding]; other site 267747005832 dimerization interface (open form) [polypeptide binding]; other site 267747005833 dimerization interface (closed form) [polypeptide binding]; other site 267747005834 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 267747005835 active site 267747005836 catalytic residues [active] 267747005837 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 267747005838 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747005839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747005840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005841 dimer interface [polypeptide binding]; other site 267747005842 conserved gate region; other site 267747005843 putative PBP binding loops; other site 267747005844 ABC-ATPase subunit interface; other site 267747005845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267747005846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005847 dimer interface [polypeptide binding]; other site 267747005848 ABC-ATPase subunit interface; other site 267747005849 putative PBP binding loops; other site 267747005850 Uncharacterized conserved protein [Function unknown]; Region: COG5476 267747005851 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 267747005852 MlrC C-terminus; Region: MlrC_C; pfam07171 267747005853 Helix-turn-helix domains; Region: HTH; cl00088 267747005854 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 267747005855 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747005856 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 267747005857 peptide binding site [polypeptide binding]; other site 267747005858 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 267747005859 dimer interface [polypeptide binding]; other site 267747005860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 267747005861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005862 dimer interface [polypeptide binding]; other site 267747005863 conserved gate region; other site 267747005864 putative PBP binding loops; other site 267747005865 ABC-ATPase subunit interface; other site 267747005866 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 267747005867 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 267747005868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747005869 dimer interface [polypeptide binding]; other site 267747005870 conserved gate region; other site 267747005871 putative PBP binding loops; other site 267747005872 ABC-ATPase subunit interface; other site 267747005873 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 267747005874 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 267747005875 Walker A/P-loop; other site 267747005876 ATP binding site [chemical binding]; other site 267747005877 Q-loop/lid; other site 267747005878 ABC transporter signature motif; other site 267747005879 Walker B; other site 267747005880 D-loop; other site 267747005881 H-loop/switch region; other site 267747005882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 267747005883 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 267747005884 Walker A/P-loop; other site 267747005885 ATP binding site [chemical binding]; other site 267747005886 Q-loop/lid; other site 267747005887 ABC transporter signature motif; other site 267747005888 Walker B; other site 267747005889 D-loop; other site 267747005890 H-loop/switch region; other site 267747005891 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 267747005892 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 267747005893 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747005894 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 267747005895 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 267747005896 putative active site [active] 267747005897 homotetrameric interface [polypeptide binding]; other site 267747005898 metal binding site [ion binding]; metal-binding site 267747005899 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 267747005900 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 267747005901 active site 267747005902 tetracycline repressor protein TetR; Provisional; Region: PRK13756 267747005903 Helix-turn-helix domains; Region: HTH; cl00088 267747005904 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747005905 Walker A/P-loop; other site 267747005906 ATP binding site [chemical binding]; other site 267747005907 Q-loop/lid; other site 267747005908 ABC transporter signature motif; other site 267747005909 Walker B; other site 267747005910 D-loop; other site 267747005911 H-loop/switch region; other site 267747005912 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747005913 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 267747005914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267747005915 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747005916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747005917 Walker A/P-loop; other site 267747005918 ATP binding site [chemical binding]; other site 267747005919 Q-loop/lid; other site 267747005920 ABC transporter signature motif; other site 267747005921 Walker B; other site 267747005922 D-loop; other site 267747005923 H-loop/switch region; other site 267747005924 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 267747005925 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747005926 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 267747005927 Walker A/P-loop; other site 267747005928 ATP binding site [chemical binding]; other site 267747005929 Q-loop/lid; other site 267747005930 ABC transporter signature motif; other site 267747005931 Walker B; other site 267747005932 D-loop; other site 267747005933 H-loop/switch region; other site 267747005934 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 267747005935 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 267747005936 Walker A/P-loop; other site 267747005937 ATP binding site [chemical binding]; other site 267747005938 Q-loop/lid; other site 267747005939 ABC transporter signature motif; other site 267747005940 Walker B; other site 267747005941 D-loop; other site 267747005942 H-loop/switch region; other site 267747005943 EcsC protein family; Region: EcsC; pfam12787 267747005944 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 267747005945 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 267747005946 Walker A/P-loop; other site 267747005947 ATP binding site [chemical binding]; other site 267747005948 Q-loop/lid; other site 267747005949 ABC transporter signature motif; other site 267747005950 Walker B; other site 267747005951 D-loop; other site 267747005952 H-loop/switch region; other site 267747005953 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 267747005954 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 267747005955 E3 interaction surface; other site 267747005956 lipoyl attachment site [posttranslational modification]; other site 267747005957 e3 binding domain; Region: E3_binding; pfam02817 267747005958 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 267747005959 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 267747005960 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 267747005961 alpha subunit interface [polypeptide binding]; other site 267747005962 TPP binding site [chemical binding]; other site 267747005963 heterodimer interface [polypeptide binding]; other site 267747005964 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267747005965 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 267747005966 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 267747005967 TPP-binding site [chemical binding]; other site 267747005968 tetramer interface [polypeptide binding]; other site 267747005969 heterodimer interface [polypeptide binding]; other site 267747005970 phosphorylation loop region [posttranslational modification] 267747005971 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 267747005972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747005973 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 267747005974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267747005975 FeS/SAM binding site; other site 267747005976 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 267747005977 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 267747005978 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 267747005979 putative active site [active] 267747005980 putative metal binding site [ion binding]; other site 267747005981 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 267747005982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747005983 H-loop/switch region; other site 267747005984 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 267747005985 WYL domain; Region: WYL; cl14852 267747005986 WYL domain; Region: WYL; cl14852 267747005987 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 267747005988 active site 267747005989 metal binding site [ion binding]; metal-binding site 267747005990 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267747005991 Integrase core domain; Region: rve; cl01316 267747005992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747005993 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 267747005994 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 267747005995 Low molecular weight phosphatase family; Region: LMWPc; cd00115 267747005996 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 267747005997 active site 267747005998 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 267747005999 proposed catalytic triad [active] 267747006000 active site nucleophile [active] 267747006001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267747006002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267747006003 active site 267747006004 phosphorylation site [posttranslational modification] 267747006005 intermolecular recognition site; other site 267747006006 dimerization interface [polypeptide binding]; other site 267747006007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267747006008 DNA binding site [nucleotide binding] 267747006009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267747006010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 267747006011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267747006012 dimer interface [polypeptide binding]; other site 267747006013 phosphorylation site [posttranslational modification] 267747006014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267747006015 ATP binding site [chemical binding]; other site 267747006016 Mg2+ binding site [ion binding]; other site 267747006017 G-X-G motif; other site 267747006018 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 267747006019 catalytic nucleophile [active] 267747006020 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 267747006021 active site 267747006022 metal binding site [ion binding]; metal-binding site 267747006023 nudix motif; other site 267747006024 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 267747006025 YCII-related domain; Region: YCII; cl00999 267747006026 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 267747006027 active site 267747006028 FMN binding site [chemical binding]; other site 267747006029 substrate binding site [chemical binding]; other site 267747006030 homotetramer interface [polypeptide binding]; other site 267747006031 catalytic residue [active] 267747006032 metabolite-proton symporter; Region: 2A0106; TIGR00883 267747006033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747006034 putative substrate translocation pore; other site 267747006035 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 267747006036 ATP cone domain; Region: ATP-cone; pfam03477 267747006037 Class I ribonucleotide reductase; Region: RNR_I; cd01679 267747006038 active site 267747006039 dimer interface [polypeptide binding]; other site 267747006040 catalytic residues [active] 267747006041 effector binding site; other site 267747006042 R2 peptide binding site; other site 267747006043 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 267747006044 dimer interface [polypeptide binding]; other site 267747006045 putative radical transfer pathway; other site 267747006046 diiron center [ion binding]; other site 267747006047 tyrosyl radical; other site 267747006048 Bacterial membrane flanked domain; Region: DUF304; cl01348 267747006049 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 267747006050 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 267747006051 arginine-tRNA ligase; Region: PLN02286 267747006052 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 267747006053 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 267747006054 active site 267747006055 HIGH motif; other site 267747006056 KMSK motif region; other site 267747006057 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 267747006058 tRNA binding surface [nucleotide binding]; other site 267747006059 anticodon binding site; other site 267747006060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267747006061 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 267747006062 active site 267747006063 catalytic tetrad [active] 267747006064 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 267747006065 putative active site [active] 267747006066 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 267747006067 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 267747006068 active site 267747006069 dimer interface [polypeptide binding]; other site 267747006070 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 267747006071 dimer interface [polypeptide binding]; other site 267747006072 active site 267747006073 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 267747006074 active site 267747006075 intersubunit interface [polypeptide binding]; other site 267747006076 catalytic residue [active] 267747006077 Ferritin-like domain; Region: Ferritin; pfam00210 267747006078 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 267747006079 dimerization interface [polypeptide binding]; other site 267747006080 DPS ferroxidase diiron center [ion binding]; other site 267747006081 ion pore; other site 267747006082 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 267747006083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267747006084 ATP binding site [chemical binding]; other site 267747006085 putative Mg++ binding site [ion binding]; other site 267747006086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267747006087 nucleotide binding region [chemical binding]; other site 267747006088 ATP-binding site [chemical binding]; other site 267747006089 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 267747006090 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 267747006091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 267747006092 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 267747006093 ATP cone domain; Region: ATP-cone; pfam03477 267747006094 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 267747006095 Class III ribonucleotide reductase; Region: RNR_III; cd01675 267747006096 active site 267747006097 Zn binding site [ion binding]; other site 267747006098 glycine loop; other site 267747006099 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 267747006100 substrate binding site [chemical binding]; other site 267747006101 Cutinase; Region: Cutinase; cl15711 267747006102 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 267747006103 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747006104 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 267747006105 NodB motif; other site 267747006106 active site 267747006107 catalytic site [active] 267747006108 metal binding site [ion binding]; metal-binding site 267747006109 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 267747006110 Predicted permease; Region: DUF318; cl00487 267747006111 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 267747006112 NodB motif; other site 267747006113 active site 267747006114 catalytic site [active] 267747006115 metal binding site [ion binding]; metal-binding site 267747006116 MviN-like protein; Region: MVIN; pfam03023 267747006117 aspartate kinase; Reviewed; Region: PRK06635 267747006118 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 267747006119 putative nucleotide binding site [chemical binding]; other site 267747006120 putative catalytic residues [active] 267747006121 putative Mg ion binding site [ion binding]; other site 267747006122 putative aspartate binding site [chemical binding]; other site 267747006123 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 267747006124 putative allosteric regulatory site; other site 267747006125 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 267747006126 putative allosteric regulatory residue; other site 267747006127 Transglycosylase; Region: Transgly; cl07896 267747006128 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 267747006129 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 267747006130 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 267747006131 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 267747006132 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 267747006133 putative active site [active] 267747006134 putative metal binding site [ion binding]; other site 267747006135 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 267747006136 proposed catalytic triad [active] 267747006137 conserved cys residue [active] 267747006138 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 267747006139 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 267747006140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 267747006141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747006142 ABC-ATPase subunit interface; other site 267747006143 putative PBP binding loops; other site 267747006144 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 267747006145 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 267747006146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747006147 dimer interface [polypeptide binding]; other site 267747006148 conserved gate region; other site 267747006149 putative PBP binding loops; other site 267747006150 ABC-ATPase subunit interface; other site 267747006151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 267747006152 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 267747006153 Walker A/P-loop; other site 267747006154 ATP binding site [chemical binding]; other site 267747006155 Q-loop/lid; other site 267747006156 ABC transporter signature motif; other site 267747006157 Walker B; other site 267747006158 D-loop; other site 267747006159 H-loop/switch region; other site 267747006160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 267747006161 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 267747006162 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 267747006163 Walker A/P-loop; other site 267747006164 ATP binding site [chemical binding]; other site 267747006165 Q-loop/lid; other site 267747006166 ABC transporter signature motif; other site 267747006167 Walker B; other site 267747006168 D-loop; other site 267747006169 H-loop/switch region; other site 267747006170 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 267747006171 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 267747006172 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 267747006173 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 267747006174 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 267747006175 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 267747006176 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 267747006177 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 267747006178 urocanate hydratase; Provisional; Region: PRK05414 267747006179 urocanate hydratase; Provisional; Region: PRK05414 267747006180 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 267747006181 allantoate amidohydrolase; Reviewed; Region: PRK09290 267747006182 active site 267747006183 metal binding site [ion binding]; metal-binding site 267747006184 dimer interface [polypeptide binding]; other site 267747006185 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 267747006186 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 267747006187 active site 267747006188 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 267747006189 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 267747006190 active site 267747006191 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 267747006192 active sites [active] 267747006193 tetramer interface [polypeptide binding]; other site 267747006194 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 267747006195 NAD-dependent deacetylase; Provisional; Region: PRK14138 267747006196 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 267747006197 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 267747006198 Bacterial SH3 domain; Region: SH3_3; cl02551 267747006199 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 267747006200 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 267747006201 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 267747006202 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 267747006203 potassium/proton antiporter; Reviewed; Region: PRK05326 267747006204 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 267747006205 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 267747006206 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 267747006207 nucleoside/Zn binding site; other site 267747006208 dimer interface [polypeptide binding]; other site 267747006209 catalytic motif [active] 267747006210 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 267747006211 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 267747006212 Uncharacterized conserved protein [Function unknown]; Region: COG3777 267747006213 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 267747006214 active site 267747006215 catalytic site [active] 267747006216 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 267747006217 putative deacylase active site [active] 267747006218 Amino acid permease; Region: AA_permease; cl00524 267747006219 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 267747006220 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 267747006221 catalytic triad [active] 267747006222 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 267747006223 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 267747006224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747006225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747006226 DNA binding site [nucleotide binding] 267747006227 domain linker motif; other site 267747006228 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 267747006229 ligand binding site [chemical binding]; other site 267747006230 dimerization interface (open form) [polypeptide binding]; other site 267747006231 dimerization interface (closed form) [polypeptide binding]; other site 267747006232 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 267747006233 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 267747006234 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 267747006235 Sodium:solute symporter family; Region: SSF; cl00456 267747006236 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 267747006237 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 267747006238 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 267747006239 NAD(P) binding site [chemical binding]; other site 267747006240 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 267747006241 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 267747006242 Ligand Binding Site [chemical binding]; other site 267747006243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267747006244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 267747006245 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 267747006246 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 267747006247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 267747006248 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 267747006249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747006250 active site 267747006251 motif I; other site 267747006252 motif II; other site 267747006253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747006254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747006255 Walker A/P-loop; other site 267747006256 ATP binding site [chemical binding]; other site 267747006257 Q-loop/lid; other site 267747006258 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 267747006259 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 267747006260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267747006261 non-specific DNA binding site [nucleotide binding]; other site 267747006262 salt bridge; other site 267747006263 sequence-specific DNA binding site [nucleotide binding]; other site 267747006264 Cupin domain; Region: Cupin_2; cl09118 267747006265 B3/4 domain; Region: B3_4; cl11458 267747006266 Sodium:solute symporter family; Region: SSF; cl00456 267747006267 oxidoreductase; Provisional; Region: PRK10015 267747006268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006269 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 267747006270 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 267747006271 Ligand binding site [chemical binding]; other site 267747006272 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 267747006273 CoA-transferase family III; Region: CoA_transf_3; pfam02515 267747006274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267747006275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267747006276 active site 267747006277 Transcriptional regulator [Transcription]; Region: IclR; COG1414 267747006278 Helix-turn-helix domains; Region: HTH; cl00088 267747006279 Bacterial transcriptional regulator; Region: IclR; pfam01614 267747006280 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 267747006281 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 267747006282 nucleotide binding site/active site [active] 267747006283 HIT family signature motif; other site 267747006284 catalytic residue [active] 267747006285 seryl-tRNA synthetase; Provisional; Region: PRK05431 267747006286 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 267747006287 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 267747006288 dimer interface [polypeptide binding]; other site 267747006289 active site 267747006290 motif 1; other site 267747006291 motif 2; other site 267747006292 motif 3; other site 267747006293 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 267747006294 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 267747006295 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 267747006296 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 267747006297 NAD binding pocket [chemical binding]; other site 267747006298 beta-alpha-beta structure motif; other site 267747006299 Bacitracin resistance protein BacA; Region: BacA; cl00858 267747006300 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 267747006301 Ferritin-like domain; Region: Ferritin; pfam00210 267747006302 ferroxidase diiron center [ion binding]; other site 267747006303 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 267747006304 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 267747006305 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 267747006306 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 267747006307 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 267747006308 dimer interface [polypeptide binding]; other site 267747006309 ssDNA binding site [nucleotide binding]; other site 267747006310 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267747006311 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 267747006312 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 267747006313 active site residue [active] 267747006314 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267747006315 active site 267747006316 phosphorylation site [posttranslational modification] 267747006317 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 267747006318 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 267747006319 P-loop; other site 267747006320 active site 267747006321 phosphorylation site [posttranslational modification] 267747006322 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 267747006323 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 267747006324 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 267747006325 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 267747006326 DNA interaction; other site 267747006327 Metal-binding active site; metal-binding site 267747006328 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 267747006329 classical (c) SDRs; Region: SDR_c; cd05233 267747006330 NAD(P) binding site [chemical binding]; other site 267747006331 active site 267747006332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267747006333 putative acyl-acceptor binding pocket; other site 267747006334 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 267747006335 Domain of unknown function (DUF348); Region: DUF348; pfam03990 267747006336 Domain of unknown function (DUF348); Region: DUF348; pfam03990 267747006337 Domain of unknown function (DUF348); Region: DUF348; pfam03990 267747006338 G5 domain; Region: G5; pfam07501 267747006339 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 267747006340 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 267747006341 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 267747006342 metal-binding site [ion binding] 267747006343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 267747006344 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 267747006345 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 267747006346 metal-binding site [ion binding] 267747006347 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 267747006348 putative homotetramer interface [polypeptide binding]; other site 267747006349 putative homodimer interface [polypeptide binding]; other site 267747006350 putative allosteric switch controlling residues; other site 267747006351 putative metal binding site [ion binding]; other site 267747006352 putative homodimer-homodimer interface [polypeptide binding]; other site 267747006353 replicative DNA helicase; Region: DnaB; TIGR00665 267747006354 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 267747006355 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 267747006356 Walker A motif; other site 267747006357 ATP binding site [chemical binding]; other site 267747006358 Walker B motif; other site 267747006359 DNA binding loops [nucleotide binding] 267747006360 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 267747006361 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 267747006362 putative NAD(P) binding site [chemical binding]; other site 267747006363 dimer interface [polypeptide binding]; other site 267747006364 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 267747006365 active site 267747006366 DNA binding site [nucleotide binding] 267747006367 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 267747006368 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 267747006369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006370 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 267747006371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006372 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 267747006373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006374 Helix-turn-helix domains; Region: HTH; cl00088 267747006375 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 267747006376 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 267747006377 Cl- selectivity filter; other site 267747006378 Cl- binding residues [ion binding]; other site 267747006379 pore gating glutamate residue; other site 267747006380 dimer interface [polypeptide binding]; other site 267747006381 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747006382 Amino acid permease; Region: AA_permease; cl00524 267747006383 Transcriptional regulators [Transcription]; Region: MarR; COG1846 267747006384 Helix-turn-helix domains; Region: HTH; cl00088 267747006385 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 267747006386 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 267747006387 active site 267747006388 metal binding site [ion binding]; metal-binding site 267747006389 DNA binding site [nucleotide binding] 267747006390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 267747006391 Uncharacterized conserved protein [Function unknown]; Region: COG4717 267747006392 putative efflux protein, MATE family; Region: matE; TIGR00797 267747006393 MatE; Region: MatE; cl10513 267747006394 MatE; Region: MatE; cl10513 267747006395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267747006396 Helix-turn-helix domains; Region: HTH; cl00088 267747006397 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 267747006398 Aminotransferase class IV; Region: Aminotran_4; pfam01063 267747006399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747006400 catalytic residue [active] 267747006401 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 267747006402 putative deacylase active site [active] 267747006403 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 267747006404 NAD synthetase; Reviewed; Region: nadE; PRK02628 267747006405 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 267747006406 multimer interface [polypeptide binding]; other site 267747006407 active site 267747006408 catalytic triad [active] 267747006409 protein interface 1 [polypeptide binding]; other site 267747006410 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 267747006411 homodimer interface [polypeptide binding]; other site 267747006412 NAD binding pocket [chemical binding]; other site 267747006413 ATP binding pocket [chemical binding]; other site 267747006414 Mg binding site [ion binding]; other site 267747006415 active-site loop [active] 267747006416 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 267747006417 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 267747006418 active site 267747006419 ADP/pyrophosphate binding site [chemical binding]; other site 267747006420 dimerization interface [polypeptide binding]; other site 267747006421 allosteric effector site; other site 267747006422 fructose-1,6-bisphosphate binding site; other site 267747006423 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 267747006424 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 267747006425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006426 Amino acid permease; Region: AA_permease; cl00524 267747006427 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747006428 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 267747006429 Bacterial SH3 domain; Region: SH3_3; cl02551 267747006430 Bacterial SH3 domain; Region: SH3_3; cl02551 267747006431 Bacterial SH3 domain; Region: SH3_3; cl02551 267747006432 origin recognition complex 1 protein; Provisional; Region: PTZ00112 267747006433 Bacterial SH3 domain; Region: SH3_3; cl02551 267747006434 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 267747006435 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 267747006436 dimer interface [polypeptide binding]; other site 267747006437 Citrate synthase; Region: Citrate_synt; pfam00285 267747006438 active site 267747006439 citrylCoA binding site [chemical binding]; other site 267747006440 NADH binding [chemical binding]; other site 267747006441 cationic pore residues; other site 267747006442 oxalacetate/citrate binding site [chemical binding]; other site 267747006443 coenzyme A binding site [chemical binding]; other site 267747006444 catalytic triad [active] 267747006445 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 267747006446 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 267747006447 active site 267747006448 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 267747006449 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 267747006450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006451 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 267747006452 Helix-turn-helix domains; Region: HTH; cl00088 267747006453 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 267747006454 Helix-turn-helix domains; Region: HTH; cl00088 267747006455 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 267747006456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006457 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 267747006458 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 267747006459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267747006460 catalytic residue [active] 267747006461 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 267747006462 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 267747006463 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 267747006464 B12 binding site [chemical binding]; other site 267747006465 cobalt ligand [ion binding]; other site 267747006466 conserved hypothetical protein; Region: glmL_fam; TIGR01319 267747006467 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 267747006468 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 267747006469 active site 267747006470 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267747006471 dimer interface [polypeptide binding]; other site 267747006472 substrate binding site [chemical binding]; other site 267747006473 catalytic residue [active] 267747006474 Amino acid permease; Region: AA_permease; cl00524 267747006475 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747006476 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 267747006477 Amino acid permease; Region: AA_permease; cl00524 267747006478 alanine racemase; Reviewed; Region: alr; PRK00053 267747006479 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 267747006480 active site 267747006481 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267747006482 dimer interface [polypeptide binding]; other site 267747006483 substrate binding site [chemical binding]; other site 267747006484 catalytic residues [active] 267747006485 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 267747006486 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 267747006487 active site 267747006488 substrate binding site [chemical binding]; other site 267747006489 metal binding site [ion binding]; metal-binding site 267747006490 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 267747006491 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 267747006492 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 267747006493 active site 267747006494 Substrate binding site; other site 267747006495 Mg++ binding site; other site 267747006496 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 267747006497 fumarate hydratase; Reviewed; Region: fumC; PRK00485 267747006498 Class II fumarases; Region: Fumarase_classII; cd01362 267747006499 active site 267747006500 tetramer interface [polypeptide binding]; other site 267747006501 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 267747006502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747006503 dimer interface [polypeptide binding]; other site 267747006504 conserved gate region; other site 267747006505 putative PBP binding loops; other site 267747006506 ABC-ATPase subunit interface; other site 267747006507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267747006508 dimer interface [polypeptide binding]; other site 267747006509 conserved gate region; other site 267747006510 putative PBP binding loops; other site 267747006511 ABC-ATPase subunit interface; other site 267747006512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 267747006513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 267747006514 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747006515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747006516 DNA binding site [nucleotide binding] 267747006517 domain linker motif; other site 267747006518 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 267747006519 putative dimerization interface [polypeptide binding]; other site 267747006520 putative ligand binding site [chemical binding]; other site 267747006521 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 267747006522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 267747006523 Glycerate kinase family; Region: Gly_kinase; cl00841 267747006524 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 267747006525 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 267747006526 active site 267747006527 NTP binding site [chemical binding]; other site 267747006528 metal binding triad [ion binding]; metal-binding site 267747006529 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 267747006530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267747006531 Zn2+ binding site [ion binding]; other site 267747006532 Mg2+ binding site [ion binding]; other site 267747006533 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267747006534 ATP binding site [chemical binding]; other site 267747006535 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 267747006536 glycerol kinase; Provisional; Region: glpK; PRK00047 267747006537 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 267747006538 N- and C-terminal domain interface [polypeptide binding]; other site 267747006539 putative active site [active] 267747006540 putative MgATP binding site [chemical binding]; other site 267747006541 catalytic site [active] 267747006542 metal binding site [ion binding]; metal-binding site 267747006543 putative homotetramer interface [polypeptide binding]; other site 267747006544 putative glycerol binding site [chemical binding]; other site 267747006545 homodimer interface [polypeptide binding]; other site 267747006546 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 267747006547 amphipathic channel; other site 267747006548 Asn-Pro-Ala signature motifs; other site 267747006549 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 267747006550 Helix-turn-helix domains; Region: HTH; cl00088 267747006551 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 267747006552 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 267747006553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267747006554 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 267747006555 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 267747006556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006558 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 267747006559 probable active site [active] 267747006560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267747006561 putative substrate translocation pore; other site 267747006562 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 267747006563 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 267747006564 substrate binding pocket [chemical binding]; other site 267747006565 OsmC-like protein; Region: OsmC; cl00767 267747006566 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 267747006567 catalytic residues [active] 267747006568 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 267747006569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267747006570 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 267747006571 transketolase; Reviewed; Region: PRK05899 267747006572 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 267747006573 TPP-binding site [chemical binding]; other site 267747006574 dimer interface [polypeptide binding]; other site 267747006575 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 267747006576 PYR/PP interface [polypeptide binding]; other site 267747006577 dimer interface [polypeptide binding]; other site 267747006578 TPP binding site [chemical binding]; other site 267747006579 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267747006580 ribulokinase; Provisional; Region: PRK04123 267747006581 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 267747006582 putative N- and C-terminal domain interface [polypeptide binding]; other site 267747006583 putative active site [active] 267747006584 putative MgATP binding site [chemical binding]; other site 267747006585 catalytic site [active] 267747006586 metal binding site [ion binding]; metal-binding site 267747006587 carbohydrate binding site [chemical binding]; other site 267747006588 homodimer interface [polypeptide binding]; other site 267747006589 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 267747006590 active site 267747006591 metal binding site [ion binding]; metal-binding site 267747006592 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 267747006593 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 267747006594 N- and C-terminal domain interface [polypeptide binding]; other site 267747006595 putative active site [active] 267747006596 putative MgATP binding site [chemical binding]; other site 267747006597 catalytic site [active] 267747006598 metal binding site [ion binding]; metal-binding site 267747006599 putative carbohydrate binding site [chemical binding]; other site 267747006600 putative homodimer interface [polypeptide binding]; other site 267747006601 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 267747006602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747006603 active site 267747006604 motif I; other site 267747006605 motif II; other site 267747006606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267747006607 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 267747006608 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 267747006609 active site 267747006610 Zn2+ binding site [ion binding]; other site 267747006611 intersubunit interface [polypeptide binding]; other site 267747006612 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 267747006613 Helix-turn-helix domains; Region: HTH; cl00088 267747006614 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 267747006615 mannonate dehydratase; Provisional; Region: PRK03906 267747006616 mannonate dehydratase; Region: uxuA; TIGR00695 267747006617 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 267747006618 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 267747006619 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 267747006620 Glucuronate isomerase; Region: UxaC; cl00829 267747006621 Transcriptional regulators [Transcription]; Region: PurR; COG1609 267747006622 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 267747006623 DNA binding site [nucleotide binding] 267747006624 domain linker motif; other site 267747006625 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 267747006626 dimerization interface [polypeptide binding]; other site 267747006627 ligand binding site [chemical binding]; other site 267747006628 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 267747006629 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 267747006630 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 267747006631 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 267747006632 putative active site [active] 267747006633 putative catalytic site [active] 267747006634 beta-D-glucuronidase; Provisional; Region: PRK10150 267747006635 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 267747006636 domain; Region: Glyco_hydro_2; pfam00703 267747006637 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 267747006638 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 267747006639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267747006640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267747006641 homodimer interface [polypeptide binding]; other site 267747006642 catalytic residue [active] 267747006643 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 267747006644 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 267747006645 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 267747006646 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 267747006647 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 267747006648 ParB-like partition proteins; Region: parB_part; TIGR00180 267747006649 ParB-like nuclease domain; Region: ParBc; cl02129 267747006650 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 267747006651 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267747006652 P-loop; other site 267747006653 Magnesium ion binding site [ion binding]; other site 267747006654 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267747006655 Magnesium ion binding site [ion binding]; other site 267747006656 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 267747006657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 267747006658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 267747006659 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267747006660 catalytic residue [active] 267747006661 FemAB family; Region: FemAB; cl11444 267747006662 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 267747006663 G-X-X-G motif; other site 267747006664 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 267747006665 RxxxH motif; other site 267747006666 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 267747006667 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 267747006668 Domain of unknown function DUF37; Region: DUF37; cl00506 267747006669 Ribonuclease P; Region: Ribonuclease_P; cl00457 267747006670 Ribosomal protein L34; Region: Ribosomal_L34; cl00370